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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARK3</accession>
    <name>A0A3P9ARK3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARK3"/>
    <dbReference type="Ensembl" id="ENSMZET00005000393.1">
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        <property type="gene ID" value="ENSMZEG00005000327.1"/>
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        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="89" mass="9043" checksum="73F47433DDFCC88F" modified="2019-02-13" version="1">MAAIVGLPAGGSLVAATNYYQRCISSTCSSSSSSSLISSPTGMTPLTEEAQHKAGVLGVVTNSQITCVSWEMVITSEDAGGQSLRSSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASE3</accession>
    <name>A0A3P9ASE3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 31</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012775458.1">
        <property type="nucleotide sequence ID" value="XM_012920004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASE3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000640"/>
    <dbReference type="Ensembl" id="ENSMZET00005000713.1">
        <property type="protein sequence ID" value="ENSMZEP00005000640.1"/>
        <property type="gene ID" value="ENSMZEG00005000585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470426"/>
    <dbReference type="KEGG" id="mze:101470426"/>
    <dbReference type="GeneTree" id="ENSGT00940000161036"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47678">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47678:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="518"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSMZEP00005000640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="609" mass="68079" checksum="F286CEBE93738A4D" modified="2019-02-13" version="1">MEIYREEEEIPDPHMFRTVLGMFEGRPHMQRIIRCGLLGIDYDDDLDDPGNDDYVTGSWSHDFHGYPANRLRSSSAVYQPVYPSARNSSCPSPLRFQTKEHDAERKARLLEESKKMKDKAEKKRLKKRKQKERKRLEKLEKDKLNPEKNEEGKDDAEEGEAVNDEHRANNNTSVKPQASAKDTDSSDSSDVSSDEDGNSKNDSGDSEELDMTSSFVRKAALIAMHKLEQKPKLEKKEKRKMPEKEEYKTVPEKSHEEREAAKKDSAASSVPSFEDHVKISTELAVIGNKHASAGDFNMAVKYFTDAIKHNPKEFKLFGNRSFCFEKLQEYEKALMDAELSLGICPGWDKGLYRKGRALAGLKRYEEAALAFTEVLKLDSSCAEAAQELMRVQITQLMEFGFTREQSSNALIIHGTVKKALEVLSKLNDRPGALPNGSLPPVQVANVTGVSPILSANTIAAPAAAVRPAQSKDALKKTLMNKPLGAVQNTSAAQSQSKPILTQPMKASNGVNRPSLELFPVWVGNLNFPVTDSMLANLFNKVGVVYSVKVLTAKRCAFVNYTKQEYCDEAIRRFHGFELNHNKLAVRYPDRIPAGLGISRSALRADDLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASI9</accession>
    <name>A0A3P9ASI9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASI9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000347"/>
    <dbReference type="Ensembl" id="ENSMZET00005000406.1">
        <property type="protein sequence ID" value="ENSMZEP00005000347.1"/>
        <property type="gene ID" value="ENSMZEG00005000230.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00590000083139"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034362">
        <property type="term" value="C:low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034359">
        <property type="term" value="C:mature chylomicron"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034361">
        <property type="term" value="C:very-low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006642">
        <property type="term" value="P:triglyceride mobilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.230.10:FF:000003">
        <property type="entry name" value="Apolipoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.50.20">
        <property type="entry name" value="Lipovitellin. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052418">
        <property type="entry name" value="Apolipoprotein_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015817">
        <property type="entry name" value="Vitellinogen_open_b-sht_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13769">
        <property type="entry name" value="APOLIPOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13769:SF1">
        <property type="entry name" value="APOLIPOPROTEIN B-100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="6" id="KW-0162">Chylomicron</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="11" id="KW-0427">LDL</keyword>
    <keyword evidence="10" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="18" id="KW-0850">VLDL</keyword>
    <feature type="domain" description="Vitellogenin" evidence="20">
        <location>
            <begin position="11"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="763" mass="85107" checksum="FE985426F2AE3C67" modified="2019-02-13" version="1">SWVCPGASSRYRHFRRFVYDYEAETFNTVNGATDNKSGPKVSCTVEVDVPQTCSFILRTTDCSLSEVVGVDDEGNPLYRPAAGAEAFKAAMEKNTLKITVEGQTDVRLYPEDNEPVNILNIKRGIVSALMVPVMEEEKNNEMPTVHGVCSTDFTVNNKQDIATDVTVSRDLSRCDWFTARRQDTSPLALVSGMVRKYGLSKLIRSTQSCNYRFDNQKKHMTSGTCTEKHIFLPLSHENQYGISAMVKQTVTLRATAKINDRIFDHSEYLPMDVVDDKSPVQTMDAVAATMQKLNSLSETNEGEKRAGLFRQLVSEFRGLKGDTLNSAIVEMTDISPSLTWQALAQCGTPECTSAMLKLLRTFHEAAVEVDAVVYALGLLPNPSQQMVKDLLAMAQYKQSKPIMYALSNAARKLYKSEGVTPEITAVYNYIASLLGADCAGDKDLTFLTLRVVGNMGDAMEATDPAIKTTLLKCMRQPATTLSVQLAAIQAFRRMSVTDEVTNHIPLLHEESPCFPKRLAAYLILMRNPEDSDIEVVKKLLNQEQNEQIRAFVSSHIYNIISSTDSETKKLGEKIMDALQDTEVSTHSDYTTKSRNYELGMAHESMAAKIQGNVIFDPSSTLPREVLLETTLNAFGYSMDIWEVGMEGKGFEPTIEALFGKNGFFPDTVSKALYWAEEQMSPKIKEVLEKWVAPLKIEGQKLVKDLQNRESPEVMAYLRLMGAELGYIKNHHGAKPGQTFHPCSTGHHEILKNQVKKNLITYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATD4</accession>
    <name>A0A3P9ATD4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 104</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM104 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004556449.1">
        <property type="nucleotide sequence ID" value="XM_004556392.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATD4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000980"/>
    <dbReference type="Ensembl" id="ENSMZET00005001059.1">
        <property type="protein sequence ID" value="ENSMZEP00005000980.1"/>
        <property type="gene ID" value="ENSMZEG00005000844.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464715"/>
    <dbReference type="KEGG" id="mze:101464715"/>
    <dbReference type="CTD" id="54868"/>
    <dbReference type="GeneTree" id="ENSGT00390000001244"/>
    <dbReference type="OrthoDB" id="294541at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
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        <location>
            <begin position="204"/>
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        <location>
            <begin position="236"/>
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        <location>
            <begin position="303"/>
            <end position="330"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="375"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="396"/>
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            <end position="489"/>
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        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
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    </evidence>
    <sequence length="494" mass="55415" checksum="022CD36DFA85096E" modified="2019-02-13" version="1">MAGGITDTGEPYSPFVGLVYMFNLIVGTGALTMPKAFAQAGWVVSLALITFLGFMSYMTTTFVIEAMAAANAQLRWKRREQEEQVENSDSTSEYSDDDEVTCRGRSEPETRPILSVQRSGQADHFDIMERVEMGQMASMFFNKVGVNMFYICIIVYLYGDLAIYAAAVPISLMEVACGNHSCSAGSVKYNDTDPCWGSVTRKDAYRVFLSVFTVLLGPFTFFNAQKTKYLQILTSLMRWIAFTMMIILAVIRIGKDHGAGHPPVASLSGVPNLFGVCVYSFMCQHSLPSLVTPISNKKRVGSLVLFDYILILGFYVLLSFTAIFCFDSSLLYDMYTLNFTDNCDVLDIPVLRYFLGLFPVFTISTNFPIIAVTLRNNWKTLFHRDGGTYPWVVDRVVFPLITLVPPIVVAFCTHNLESLVGITGSYAGTGIQYIVPAFLVFYARRHLEPVMGRDAINKHRSPFRHSFWVWFVLLWAAFSLMFVTANIILTDTKN</sequence>
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    <name>A0A3P9AU78_9CICH</name>
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        <name type="scientific">Maylandia zebra</name>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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    <dbReference type="STRING" id="106582.ENSMZEP00005001254"/>
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            <begin position="188"/>
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            <begin position="80"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="Pfam" id="PF02225"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="301" mass="33323" checksum="BCABA1AC8ED3AFDB" modified="2019-02-13" version="1">MAPGLLVAACRSLALSTWLLSFCFVHLLCLDFTVAEREEWYTAFVNITYVDPATSELRTEKTECGRYGEHSPKRDAKGVLVLPAAPLDRQACDPNTRFAVPGNCTYKDKIRHAAAHNASAVVIFNVGSTNTNDTITMPHPGASEVVAIMIPEPKGREIVSLLERNVTITMTITIGTRSLQKYVSRTSVVFVSIFFIVLMIISIVWLIFCYIKRFRYANAGDQNQARTRVCAADPELGYSLCLCCSHVGGQQCFTNITDSCQCYTSASQIHLWYQSENATSPRSQVNMFTVLGVHSADTLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUC4</accession>
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    <reference evidence="8" key="1">
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Peptidase_S1_PA"/>
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    <dbReference type="PANTHER" id="PTHR24253:SF144">
        <property type="entry name" value="CHYMOTRYPSIN-LIKE PROTEASE CTRL-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
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        <location>
            <begin position="1"/>
            <end position="170"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="236" mass="25550" checksum="6B8BF3C9185B1B00" modified="2019-02-13" version="1">MVVLLGSNRVLDPDPNKVRLNVINATCHPGFNSSTRENNICLLKLSAPVNFTDYIQPICLASENSTFNNETSSWAIGFGDIEALRYNLQEAKVSVVGNDVCKARFPWIPDSIICTRETNSCWDKLGAPLMTQSKSVWLQSGVFTVPGCTASPSVYTPVSQYQKWISDTVTGTPPGFVTFTSPHSSLQTTAPPTAPPTSPTCVGVFCSGENLIHFTHFSSLCVLVVLLHVFAGTFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWW4</accession>
    <name>A0A3P9AWW4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neprilysin</fullName>
            <ecNumber evidence="5">3.4.24.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Atriopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Enkephalinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Neutral endopeptidase 24.11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Skin fibroblast elastase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="33 34">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.</text>
            <dbReference type="EC" id="3.4.24.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>neurotensin + H2O = neurotensin(1-10) + L-tyrosyl-L-isoleucyl-L-leucine</text>
            <dbReference type="Rhea" id="RHEA:71479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:147362"/>
            <dbReference type="ChEBI" id="CHEBI:190705"/>
            <dbReference type="ChEBI" id="CHEBI:190707"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:71480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>neurotensin + H2O = neurotensin(1-11) + L-isoleucyl-L-leucine</text>
            <dbReference type="Rhea" id="RHEA:71475"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:147362"/>
            <dbReference type="ChEBI" id="CHEBI:190704"/>
            <dbReference type="ChEBI" id="CHEBI:190706"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:71476"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>substance P + H2O = substance P(1-7) + L-Phe-Gly-L-Leu-L-Met-NH2</text>
            <dbReference type="Rhea" id="RHEA:71467"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:190692"/>
            <dbReference type="ChEBI" id="CHEBI:190695"/>
            <dbReference type="ChEBI" id="CHEBI:190698"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:71468"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>substance P + H2O = substance P(1-9) + L-Leu-L-Met-NH2</text>
            <dbReference type="Rhea" id="RHEA:71459"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:190692"/>
            <dbReference type="ChEBI" id="CHEBI:190693"/>
            <dbReference type="ChEBI" id="CHEBI:190700"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:71460"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.11" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWW4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002176"/>
    <dbReference type="GlyCosmos" id="A0A3P9AWW4">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005002277.1">
        <property type="protein sequence ID" value="ENSMZEP00005002176.1"/>
        <property type="gene ID" value="ENSMZEG00005001703.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156745"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097242">
        <property type="term" value="P:amyloid-beta clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF114">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="32">
        <location>
            <begin position="99"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="31">
        <location>
            <begin position="563"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00031362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00031486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00032584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="738" mass="84325" checksum="B39B9F57BB9D6280" modified="2019-02-13" version="1">MPIYIIDRKFPDISGELIQAAVEEGVPRMTETNTPKSAKKLRWTSLEIGLITIVSLLFIVIIALIILFATQKTDEICTTADCTQSASRLIENMDANVDPCDNFYQYACGGWLKKNIIPETTSRYSTFDILRDELEVILKGVLEKTVEGEAAALTKAKTLYKSCTNESLIELRGGSPLLDMLPDVSEWPIAVDNWETNYGRTWRLEDVIAKLNEKYGTLLLVNFFVGTDDRDSTSHIIHFDQQTSLGLVSRDYYACTGPYAEACRAYEQFMIDLAKLMRKDRGLAINETRIREEVTRVIDLERDIANATDTPEDRNNPVLLYNKMELGDLNANFTLEVESQLFDWSYFTAKIMNTVNISVPDTEKVINYSPNYYRRLNLILAKYTKRDLQNYMVWRFAMNMVVGLSRAYRDTRKAFRKALSGTTSEAAVWRQCALYVNNNLENAVGRLYVQEAFSEKSKELMEEMIKGIREVFISNLDDLTWMDAETKKAAEEKARAIRERIGYSDNIMDGEYLNNEYKDLSYSAEEYFENILQNLEYVQKKRLRKLRVKVNKEEWVTGAAVVNAFYSSSKNQIVFPAGILQPPFFSKGQAKSLNYGGIGMVIGHEITHGFDDNGRNYDKDGDLKDWWTPDSTQRFLELSKCIVDQYGNFSWDLASGLHLNGNNTLGENIADNGGIRQAYQAYKNYVKQHGEEPPLPGIDLSHDQLFFLNFAQVWCGTHRPEQAVNSIKVDVHSPGKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYE1</accession>
    <name>A0A3P9AYE1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Zona pellucida sperm-binding protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Zona pellucida</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14">Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ZP domain family. ZPC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538023.1">
        <property type="nucleotide sequence ID" value="XM_004537966.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYE1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002664"/>
    <dbReference type="Ensembl" id="ENSMZET00005002779.1">
        <property type="protein sequence ID" value="ENSMZEP00005002664.1"/>
        <property type="gene ID" value="ENSMZEG00005002106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478059"/>
    <dbReference type="KEGG" id="mze:101478059"/>
    <dbReference type="GeneTree" id="ENSGT01030000234567"/>
    <dbReference type="OrthoDB" id="8880842at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035805">
        <property type="term" value="C:egg coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032190">
        <property type="term" value="F:acrosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035804">
        <property type="term" value="F:structural constituent of egg coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035803">
        <property type="term" value="P:egg coat formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000344">
        <property type="term" value="P:positive regulation of acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3210:FF:000001">
        <property type="entry name" value="Zona pellucida sperm-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4100:FF:000002">
        <property type="entry name" value="Zona pellucida sperm-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017977">
        <property type="entry name" value="ZP_dom_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11576">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11576:SF2">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00682">
        <property type="entry name" value="ZP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 14" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025712590" description="Zona pellucida sperm-binding protein 3" evidence="14">
        <location>
            <begin position="22"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="16">
        <location>
            <begin position="109"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="409" mass="45277" checksum="AB83CE4A9AB28056" modified="2019-02-13" version="1">MGARQLVAFSFVLAWVRLSDARFHSLNVPTHLGIKAQRPAVAEADAPGEPDRVHSSQSAQQAAKLQSKQNQQALEPLSWKFPEDPVDRVNKPFKFELKQPVAAYRVAVRCGESKIFVEVSRDLLGLGKLIKPEEISLGGCSATDTDDSSHVLVFESELHSCGSKLVLTENAFIYAFALAYNPKVFGRSGITRSQSAVIRLECHYQRQHSASSDPEHPAWMSSEATRRAQTQQHFSLKLMTDDWKFERTSTRYALVDVIHMEAAVLVQTPTPLRVLVDSCVATTKSDFTSGRREALINDGCLGGQHTISRFMPRSQPDKLRLQVAIHSLGLQGMIYISCLLKAVSASAPVTIENKACSFYEGMWMAVDGKNEFCTCCESTCGMRKIRALSDNATVERWEAEVTVGPIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B083</accession>
    <name>A0A3P9B083_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B083"/>
    <dbReference type="Ensembl" id="ENSMZET00005003477.1">
        <property type="protein sequence ID" value="ENSMZEP00005003345.1"/>
        <property type="gene ID" value="ENSMZEG00005002583.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167283"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
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                <person name="Aken B."/>
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                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
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                <person name="Eshel O."/>
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                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <subcellularLocation>
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            <topology evidence="1">Single-pass type I membrane protein</topology>
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        <text evidence="2">Belongs to the Toll-like receptor family.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1V0</accession>
    <name>A0A3P9B1V0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Complement factor D</fullName>
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    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004554830.1">
        <property type="nucleotide sequence ID" value="XM_004554773.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9B1V0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003722"/>
    <dbReference type="Ensembl" id="ENSMZET00005003875.1">
        <property type="protein sequence ID" value="ENSMZEP00005003722.1"/>
        <property type="gene ID" value="ENSMZEG00005002891.1"/>
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    <dbReference type="GeneID" id="101478226"/>
    <dbReference type="KEGG" id="mze:101478226"/>
    <dbReference type="CTD" id="1675"/>
    <dbReference type="GeneTree" id="ENSGT00940000162161"/>
    <dbReference type="OrthoDB" id="60866at2759"/>
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        <property type="component" value="LG19"/>
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        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trypsin beta"/>
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    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA"/>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
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        <property type="entry name" value="Peptidase_S1A"/>
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    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
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        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
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        <property type="entry name" value="COMPLEMENT FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
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        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="chain" id="PRO_5018309394" evidence="9">
        <location>
            <begin position="23"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="23"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="275" mass="29760" checksum="44ABEB75C5D2D1B3" modified="2019-02-13" version="1">MVSKVLVGAAVFVVALISESAGIIGGREAAPHSRPYMASIQVPEGENLKHECGGFVVADQWVMTAVHCLPNGPDGRKVMLGVHSLSEPEETKQIFDILELHNHQDFDPSNYDNDIALIKLDRPFNISEAVKAVEFLRAGGTNPDTGNEVETAGWGSVDNLGARPDKLKEVTVEVISPDRCRRSDYFGRKFTTNMICAHKVCANPCDQPHKNEDSCDGDSGGPLLYNGVVVGITSNGGKKCGQTKKPGIYTIISHYTQWIDNIMNPQPAAAEEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2I9</accession>
    <name>A0A3P9B2I9_9CICH</name>
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        <submittedName>
            <fullName evidence="13">Adenosine A3 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADORA3</name>
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    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
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    <dbReference type="Ensembl" id="ENSMZET00005004287.1">
        <property type="protein sequence ID" value="ENSMZEP00005004116.1"/>
        <property type="gene ID" value="ENSMZEG00005003192.1"/>
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    <dbReference type="GeneTree" id="ENSGT01030000234555"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
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        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001609">
        <property type="term" value="F:G protein-coupled adenosine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="CDD" id="cd14968">
        <property type="entry name" value="7tmA_Adenosine_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001634">
        <property type="entry name" value="Adenosn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF52">
        <property type="entry name" value="ADENOSINE RECEPTOR A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00424">
        <property type="entry name" value="ADENOSINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU201114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="320" mass="36003" checksum="4B5F4D8D1BD12DFD" modified="2019-02-13" version="1">MAQIGNSSSQHMDMVYISIETTIALASVVGNVLVVLVVYENRALRNATFCFIVSLAMADIAVGLLVIPLAIVISVGYYTQFYTCLFLSCLILMITQSSIFSLLAIAIDRYLRVKIPTRYSIIVTNGRAFVAICLSWILSFLTGLVPMIGWNNRDTANRSNASEICCQFTAVIRMDYMVYFNFFVCVAPPLLIMITLYVEIFRVIRKQLNRRAEATCDGDKYFRKELKLAKSLALVVFLFALCWLPIHIMNCVTLFCPNCINPIASKVGIFMSHVNSALNPLVYAFKMKHFRATLIQIIRRCMLCKPLEATAYPTSTVVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B335</accession>
    <name>A0A3P9B335_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554390.1">
        <property type="nucleotide sequence ID" value="XM_004554333.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B335"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004323"/>
    <dbReference type="Ensembl" id="ENSMZET00005004509.1">
        <property type="protein sequence ID" value="ENSMZEP00005004323.1"/>
        <property type="gene ID" value="ENSMZEG00005003346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481656"/>
    <dbReference type="KEGG" id="mze:101481656"/>
    <dbReference type="CTD" id="402"/>
    <dbReference type="GeneTree" id="ENSGT00940000157941"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="184" mass="20605" checksum="10F96FA4F56011AF" modified="2019-02-13" version="1">MGLLTILKKMKQKEREMRLLMLGLDNAGKTTILKKFNGEDVSTISPTLGFNIKTLEHKGFKLNIWDVGGQKSLRSYWRNYFESTDGLVWVVDSADRLRLEDCRQELSALLLEERLAGATLLVFANKQDLPGALSKEAIREALALDNIKSHHWCIIGCSAVTGENLLAGVDWLLDDIAARIFTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6C7</accession>
    <name>A0A3P9B6C7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoside diphosphate kinase B</fullName>
            <ecNumber evidence="10">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Major role in the synthesis of nucleoside triphosphates other than ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 23 24">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="10"/>
    <dbReference type="RefSeq" id="XP_004556566.1">
        <property type="nucleotide sequence ID" value="XM_004556509.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6C7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005440"/>
    <dbReference type="Ensembl" id="ENSMZET00005005670.1">
        <property type="protein sequence ID" value="ENSMZEP00005005440.1"/>
        <property type="gene ID" value="ENSMZEG00005004219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471779"/>
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        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:ruffle"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:GTP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside diphosphate kinase B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
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        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NDK-like_dom"/>
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        <property type="entry name" value="NDK-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
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        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
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    </dbReference>
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        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="21" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="25">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="23">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00003465"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00013499"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="149" mass="16950" checksum="ADFFD9F021A7F225" modified="2019-02-13" version="1">MERTFIAVKPDGVQRGLCGEIIKRFEHRGFRLVAAKFVQASEDHMKKHYLDLKDMPFYAGLCKYMSSGPVLAMVWEGQNIVKLARMMLGETNPADSKPGSIRGDLCINIGRNIIHGSDTLENAKMEVDLWFKAEEFVTYTPCAQSWLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6W8</accession>
    <name>A0A3P9B6W8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diencephalon/mesencephalon homeobox 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6W8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005595"/>
    <dbReference type="Ensembl" id="ENSMZET00005005834.1">
        <property type="protein sequence ID" value="ENSMZEP00005005595.1"/>
        <property type="gene ID" value="ENSMZEG00005004323.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155505"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061074">
        <property type="term" value="P:regulation of neural retina development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000125">
        <property type="entry name" value="diencephalon/mesencephalon homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052488">
        <property type="entry name" value="DMBX_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46639">
        <property type="entry name" value="DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46639:SF3">
        <property type="entry name" value="DIENCEPHALON_MESENCEPHALON HOMEOBOX PROTEIN 1-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="11">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="71"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="394" mass="43363" checksum="6359E31A5C964622" modified="2019-02-13" version="1">MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEVSGEGGSEKEDMPPSTTILSDTQLPPSSSSSSSSPETEGPVVRPVPLDMELNVTSAEHSGSESATEDNATDKEDESKSQKEEMKCERAVTPGDDSPACKRLSPKPDSPLVSPSVTPSSSSSSLASTGPLSQSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYPAFDLAAPSSLPYLGMNVNMPPAPLGSLPCQSYYQSLSHHAQQVWNSPLLQASTAGGLTSHNSKTTSIENLRLRAKQHAASLGLDTMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B798</accession>
    <name>A0A3P9B798_9CICH</name>
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        <submittedName>
            <fullName evidence="10">Scinderin like b</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570620.1">
        <property type="nucleotide sequence ID" value="XM_004570563.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B798"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005751"/>
    <dbReference type="Ensembl" id="ENSMZET00005006003.1">
        <property type="protein sequence ID" value="ENSMZEP00005005751.1"/>
        <property type="gene ID" value="ENSMZEG00005004440.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470091"/>
    <dbReference type="KEGG" id="mze:101470091"/>
    <dbReference type="CTD" id="406363"/>
    <dbReference type="GeneTree" id="ENSGT00940000164612"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
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    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:actin filament severing"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:actin polymerization or depolymerization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11291">
        <property type="entry name" value="gelsolin_S6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000001">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000004">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000005">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000040">
        <property type="entry name" value="macrophage-capping protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF27">
        <property type="entry name" value="SCINDERIN LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="9">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="9">
        <location>
            <begin position="141"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="9">
        <location>
            <begin position="260"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="9">
        <location>
            <begin position="401"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="9">
        <location>
            <begin position="520"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="9">
        <location>
            <begin position="622"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008418"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="720" mass="79257" checksum="F43A566EBF5902F6" modified="2019-02-13" version="1">MVSHKEFETAGKKPGLQVWRIESMDLKPVPKALHGSFYTGDAYLLLFTTSAPSYNIHMWLGDECSQDESGATAIFASQLDDFLGGGPVQYREVQNYESNTFLGYFKSGIKYQKGGVASGFKHVVTNGVDVKRLLHVKGRRVIRATEVNMSWDSFNKGDCFIIDLGKDIYQWCGSECNRFERLKASEVTIDIRDNERNGRAKVHMVEEGDEPAPIIEVLGPKTSIAPSTPDDDKVETSNRKKAALYMISDASGSMKVSSVAASSPFKQAMLSPEECYILDNGVDKTIFVWKGPKATVSERKAAMAAGQKFITDKGYNKNTTIQVLPAGGETSLFKQFFSDWRDKDETTGPSKAYTIGRIAKVEQVPFDASTLHTNKAMAAQHGMVDDGKGKVQIWRVENGANVPVDPSSYGHFYGGDCYLILYSYRQGSREQHIIYTWQGLKCTQDELAASAFLTVKLDDSMGGAPVQVRVSQGQEPPHLMSIFKDKPMIIHSGGTSRKGGQTQAASSRLFHIRQSSSNATRAVEVQATASNLNTNDVFVLKTPSGLFVWRGVGASDKEMEAAKHVVAFLGGSPSNVSEGKEPADFWSALGGKTDYQTSKSLQSGIRPPRLFGCSNKTGRLSVEEVPGDFTQSDLATDDVMLLDTWDQVYIWIGKDANDVEKEGAPKIAKEYVDSDPSGRKGIPITTIKQGAEPPTFTGWFQAWDPKMWDTDPLDRIRARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B942</accession>
    <name>A0A3P9B942_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
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                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B942"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006405"/>
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        <property type="protein sequence ID" value="ENSMZEP00005006405.1"/>
        <property type="gene ID" value="ENSMZEG00005004955.1"/>
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        <property type="component" value="LG15"/>
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        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Serine peptidase inhibitor, Kunitz type 1"/>
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        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kunitz_BPTI"/>
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        <property type="entry name" value="Kunitz_BPTI_sf"/>
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        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
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    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="4">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="71" mass="8084" checksum="8C5D3997C6FAE78B" modified="2019-02-13" version="1">HDRHLDPCAAAPVVGPCKGTFPRWYYDQNVGECKHFLYGGCQGNHNNFLQELDCVSECIQKSESPPYIHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B943</accession>
    <name>A0A3P9B943_9CICH</name>
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        <submittedName>
            <fullName evidence="5">Endonuclease domain-containing 1 protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
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                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004569924.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_004569925.3"/>
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        <property type="nucleotide sequence ID" value="XM_004569926.3"/>
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    <dbReference type="KEGG" id="mze:101471938"/>
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        <property type="component" value="LG19"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472:SF26">
        <property type="entry name" value="ENDONUCLEASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472">
        <property type="entry name" value="ENDONUCLEASE DOMAIN-CONTAINING 1 PROTEIN ENDOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Endonuclease_NS"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="His-Me finger endonucleases"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5018244041" evidence="2">
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            <begin position="19"/>
            <end position="293"/>
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    </feature>
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        <location>
            <begin position="53"/>
            <end position="268"/>
        </location>
    </feature>
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        <location>
            <begin position="54"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00892"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="293" mass="33486" checksum="3512CE9632FE807B" modified="2019-02-13" version="1">MQSSVTVCLLLLVFPVNAHVVENFEMCMEYFYKGHVPEWTPNDHVHICQMFNNRYHFATLYDTTNRIPVYSAYVVEDGKSSDHRWMVEPQLVKQEFEEANMMTENSLIYKHRTLDPKDIGTRQATDDDYNKRPDGYSRGHLNPNSHHAGDASKATMTLTNIVPQKQSLNEKKWKDHEDTLKGWAKDNKENVYVLVGAIPSKGNWIKRDNQPGVNIPDYMWVAHCYYNKTSQSYESGGATAKNVENKIYKCTLSQLQAFLQQHNQVAAGQLFHNDCYVEQAAGASAAAENPCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9R7</accession>
    <name>A0A3P9B9R7_9CICH</name>
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        <submittedName>
            <fullName evidence="3">DnaJ (Hsp40) homolog, subfamily C, member 4</fullName>
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        <name type="scientific">Maylandia zebra</name>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004545653.2">
        <property type="nucleotide sequence ID" value="XM_004545596.3"/>
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        <property type="gene ID" value="ENSMZEG00005005099.1"/>
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        <property type="component" value="LG2"/>
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    </dbReference>
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        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="280" mass="32602" checksum="2C24C1F24C42DAC5" modified="2019-02-13" version="1">MRCYETALRCHVSTDKGTDADVDIFNGKTVKGPCVEPPKISIMLLEAQLRLCQSCFWCCKSGLRLFSQSYTQRKAATYYDLLGVKSDATLEEIKNAFFDKSKKLHPDSDPSNPALHSQFVQLNEAYRVLSKDLSRKEYDFKIRQPYGGAQVFRSASTDPSYRGSMDAYENIRYWEQVHHPHTPEMMAEEKQKRRKRNFRLVAYCVVAMMLSIGAHAVLFKKLEEVHTNFMDEKDRIIIEIYNEAKERARVNGFKKQTEILRQKHAEFKEKYKRTDVGDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCQ2</accession>
    <name>A0A3P9BCQ2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch like family member 23</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004557759.1">
        <property type="nucleotide sequence ID" value="XM_004557702.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCQ2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007546"/>
    <dbReference type="Ensembl" id="ENSMZET00005007862.1">
        <property type="protein sequence ID" value="ENSMZEP00005007546.1"/>
        <property type="gene ID" value="ENSMZEG00005005780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474706"/>
    <dbReference type="KEGG" id="mze:101474706"/>
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    <dbReference type="GeneTree" id="ENSGT00940000159106"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
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        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF304">
        <property type="entry name" value="KELCH-LIKE PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="36"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="562" mass="63546" checksum="FA329CF4C5FD68EC" modified="2019-02-13" version="1">MSHKQAEIYTYDFCDGDHPAELLDALRHFYISGLFTDVALQCGESGQVFHCHKALLSARSSYFKVMFTADMKERSNSVIKLSGIDYGVLGALVDYVYTAQVCITESNVQSLLEAADLLQFVPVKQACEEFLIRLLDVDNCLGMHAFAELHLCPGLEREARRVMLSRFPELIQQEEFLELHPEKMREVLAVQSLTVQKDEVLIDALATWVNHDLDNRIHHVSIMLHSIHLDLDEIYFKTTLDVYRQYLKKNDGKLKSIIIQALRSNGKEIPAARKMSANMYIIGGYYWHPLCEVHIWDPISNTWVQGKDMPNHARESYSVSLLGANIYVTGGYKTNTVEALDTVSIYNCDCDEWTEGCPMITARYYHCSVALHGCIYAIGGYRGGAPERDTEFYDPLKKKWFPVAKMIQGVGNATACVMGDKIYVTGGHYGYRGSCTYEKTQVYRPDVNEWSIITISPHPEYGLCSVSLNNKLYVVGGQTTIADCYDTERDEWRPISVMKERRMECGAVVINGCIYVTGGYSYSKGTYLQSIEKYNPELDSWEIVGTLPSPTRSHGCICVYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD49</accession>
    <name>A0A3P9BD49_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat domain 27</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
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                <person name="Galibert F."/>
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                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD49"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007850"/>
    <dbReference type="Ensembl" id="ENSMZET00005008168.1">
        <property type="protein sequence ID" value="ENSMZEP00005007850.1"/>
        <property type="gene ID" value="ENSMZEG00005005982.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012017"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042411">
        <property type="entry name" value="WDR27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44525:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="322" mass="35899" checksum="B027E0D06F1368C2" modified="2019-02-13" version="1">MAKMLTEKLSLTCDRLLSHRKLACCYSYFSIPQHGKEVLPLILTGHHGDISALTFGKRSSPVILCSASADYIIVWDIELCQKRTQEGKVAAGTVIGTLLGEVVHLSFCFSDARVAACTGATACILSSKRPETIHTLTGHLGPVTSAEFCPWNNDILVTTSEDRTFRVWDLKTEAVFFQSFVLSASPLLTTYFLEEDRHLITGSTDGQVWCFSLSDDHKCHLVTKMDLEKMEKRHQIKPLNMVFPYVSVWGPCSDNSWFCIGSSDGLYVVDLATSELVTALYFKGRLLGTCLLPSFCLSLRNSGMPPIKHVVSPERFHWSFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD80</accession>
    <name>A0A3P9BD80_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="9">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="9"/>
    <dbReference type="RefSeq" id="XP_004575880.1">
        <property type="nucleotide sequence ID" value="XM_004575823.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD80"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007864"/>
    <dbReference type="Ensembl" id="ENSMZET00005008182.1">
        <property type="protein sequence ID" value="ENSMZEP00005007864.1"/>
        <property type="gene ID" value="ENSMZEG00005005995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484136"/>
    <dbReference type="KEGG" id="mze:101484136"/>
    <dbReference type="CTD" id="2671"/>
    <dbReference type="GeneTree" id="ENSGT00390000001979"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="11">
        <location>
            <begin position="87"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="197" mass="22287" checksum="63C2F385808E65D8" modified="2019-02-13" version="1">MAAPTGPRGSQVPSAFEGFPFPMASRPPEDSSGKEQEQTGDVKKKPCRACTDFKSWIKMQKKQATTASGGTAQETKAADSEPQDPQCPLDREELGRSTWSFLHTMAAYYPDHPSTTQQQEMGQFINIFSKFFPCDECAQDLRDRLKTNQPDTSSRHALSQWFCRLHNNINVRLGKPEFDCSRVDERWRDGWKDGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDI7</accession>
    <name>A0A3P9BDI7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Required for excision 1-B domain containing</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004552782.1">
        <property type="nucleotide sequence ID" value="XM_004552725.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDI7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007933"/>
    <dbReference type="Ensembl" id="ENSMZET00005008253.1">
        <property type="protein sequence ID" value="ENSMZEP00005007933.1"/>
        <property type="gene ID" value="ENSMZEG00005006052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473032"/>
    <dbReference type="KEGG" id="mze:101473032"/>
    <dbReference type="CTD" id="55049"/>
    <dbReference type="GeneTree" id="ENSGT00940000166035"/>
    <dbReference type="OrthoDB" id="434723at2759"/>
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                <person name="Alcazar R."/>
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                <person name="Aken B."/>
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                <person name="Amemiya C."/>
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                <person name="Venkatesh B."/>
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            <authorList>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="123" mass="13034" checksum="3EDCE974F8306970" modified="2019-02-13" version="1">STLGSGSLHCVDLVRRPQRAQLCLVAWAAVQGVFWHADGKGQVATHAPDDDGGANVTGLYPHLPTDSGATSLCDGQAATFTATASPILKRQKTFNYSRGLNPTLCSKVSQNLFPPTSSHRNIM</sequence>
</entry>
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                <person name="Malinsky M."/>
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                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="InterPro"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="52" mass="6047" checksum="A062DAD6EB33EBEB" modified="2019-02-13" version="1">MCTTMMVLTTIALILRQRFSNKIKPVHCALVMYHLPQAERGQRSNRNREMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNV7</accession>
    <name>A0A3P9BNV7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger, CCHC domain containing 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004575057.1">
        <property type="nucleotide sequence ID" value="XM_004575000.4"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A3P9BNV7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011623"/>
    <dbReference type="Ensembl" id="ENSMZET00005012026.1">
        <property type="protein sequence ID" value="ENSMZEP00005011623.1"/>
        <property type="gene ID" value="ENSMZEG00005008724.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101463637"/>
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    <dbReference type="GeneTree" id="ENSGT00390000012556"/>
    <dbReference type="OrthoDB" id="431817at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
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        <property type="entry name" value="ZCCHC4"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493:SF3">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE ZCCHC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="11">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011623.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="496" mass="56618" checksum="2AB5914B7346D504" modified="2019-02-13" version="1">MDVNEEYGNSYGIEVILGEGGKTAPCCSHGPTLLFEKVCKGGEKSRRFYACSACRDRKDCNFFQWEDEKVSEARLLAREAESQSTRPPFPHKEYCSRFQKFVLLPLDEKKFCQDCQILLLPDEHSLHSAHISTPITAAQLRRPSALLRPLNNKKSNAQYLFTDRSANFLLDTLAGLGYRKILCVGTPRLQELIKLQNLEQKLEPIKSLLLDIDFRYAQFYSQDEFCHYNMFNHHFFGGESSSATLKNFLRESDGEKVAMVADPPFGGLVKPLANSFSLLSHTWKKLQSSDSSNANMPMIWVFPYFFEPRILECFPSFSMLDYQVDYDNHPLYKHGKMGRKQSPVRLFTNLSPRDIILPKEEGYRFCPLCERYVSSLNKHCAKCNLCPSKDGREWKHCSTCVKCVKPSWEHCQSCGRCALPDHPCTTREGKEGCFNCGSPEHKRKDCSVKHTHRFNRHRTKAKVGGKKGSPQSLLRLKAKRKSGAARRAKLLAGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNX5</accession>
    <name>A0A3P9BNX5_9CICH</name>
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        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNX5"/>
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    <dbReference type="Ensembl" id="ENSMZET00005012046.1">
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        <property type="gene ID" value="ENSMZEG00005008736.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000171952"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF134">
        <property type="entry name" value="CD48 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018075051" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="101"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="299" mass="33219" checksum="91E6566E387DF643" modified="2019-02-13" version="1">IRLVKKMVSAATIAVFLLCCYFSASSGSQDDCVYAATGSSFTVPLKHELEESANLRWFKDRTIIFYRRGKYVITGKNDYVDSTGSLKLTRLTKDMSGRYIPEVTNADGLNVGHLPSVRLCILDPVKKPKVTMTCIEAQKNVSFSCNIGQDDTIEWLMNAKQLAEKGKTVMRVAKDVANGHFSCNVSNIISSEISLPVQQNCYKPGKYYVLSIHCCFCLSPSGILLLMILTAIVCCTHKKAKVIKGKIIIIIIIIIIIIIVTSKLQPVALCMKTQACLSIYCVIVISIITVHIVRWQKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BT76</accession>
    <name>A0A3P9BT76_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Retinoic acid receptor, alpha a</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024659264.1">
        <property type="nucleotide sequence ID" value="XM_024803496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BT76"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013137"/>
    <dbReference type="Ensembl" id="ENSMZET00005013587.1">
        <property type="protein sequence ID" value="ENSMZEP00005013137.1"/>
        <property type="gene ID" value="ENSMZEG00005009857.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473358"/>
    <dbReference type="CTD" id="30680"/>
    <dbReference type="GeneTree" id="ENSGT00940000165576"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035259">
        <property type="term" value="F:nuclear glucocorticoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071376">
        <property type="term" value="P:cellular response to corticotropin-releasing hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021575">
        <property type="term" value="P:hindbrain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048384">
        <property type="term" value="P:retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06964">
        <property type="entry name" value="NR_DBD_RAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06937">
        <property type="entry name" value="NR_LBD_RAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000001">
        <property type="entry name" value="Retinoic acid receptor beta isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000004">
        <property type="entry name" value="Retinoic acid receptor beta isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047159">
        <property type="entry name" value="NR_DBD_RAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047158">
        <property type="entry name" value="NR_LBD_RAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003078">
        <property type="entry name" value="Retinoic_acid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24085:SF8">
        <property type="entry name" value="RETINOIC ACID RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01292">
        <property type="entry name" value="RETNOICACIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="15">
        <location>
            <begin position="85"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="16">
        <location>
            <begin position="183"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="455" mass="50859" checksum="B6CB9D383DC7B727" modified="2019-02-13" version="1">MMYESVDVVGLNPSPNPFLMMDYYNQSRGCLIPEKGLMPGAPHPYSTSIRNQHWNGSNHSIETQSTSSEEIVPSPPSPPPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHREKNCIINKVTRNRCQYCRLQKCLEVGMSKESVRNDRNKKKKDEKKQECTESYVLSPDTEQMIDRVRKAHQDTFPSLCQLGKYTTTNSSERRVSLDVDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRNQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLLCGDRQDLEEADKVDILQEPLLEALKIYVRKRRPHKPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLESGAAGGRPSGAPPGSCSPSLSPSSAQSSPATQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BV19</accession>
    <name>A0A3P9BV19_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Juxtaposed with another zinc finger protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with NR2C2 (via ligand-binding region).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012773720.1">
        <property type="nucleotide sequence ID" value="XM_012918266.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BV19"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013719"/>
    <dbReference type="Ensembl" id="ENSMZET00005014188.1">
        <property type="protein sequence ID" value="ENSMZEP00005013719.1"/>
        <property type="gene ID" value="ENSMZEG00005010334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466322"/>
    <dbReference type="KEGG" id="mze:101466322"/>
    <dbReference type="GeneTree" id="ENSGT00390000003635"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000619">
        <property type="entry name" value="juxtaposed with another zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003264">
        <property type="entry name" value="Juxtaposed with another zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF1">
        <property type="entry name" value="JAZF ZINC FINGER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="243" mass="26986" checksum="335B8C5BD064A7C8" modified="2019-02-13" version="1">MTGIAAASFFSNSCRFGGCGLQFESLAELIVHIEDNHIDTDPRVLEKQEQQQPTYLALSYINRFMTDAARREQETIKKKATPKLSLSITGGVSRNSTATPPRHTSGNLTPPVTPPITPSSSFRSSTPTGSEYDEEEVDYEESDSDESWTTESAISSESILSSMSMNGADEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTSQGLRHHTINFHPPVSTEILRKIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVF6</accession>
    <name>A0A3P9BVF6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RAN binding protein 10</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RANBP9/10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564667.1">
        <property type="nucleotide sequence ID" value="XM_004564610.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVF6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013621"/>
    <dbReference type="Ensembl" id="ENSMZET00005014086.1">
        <property type="protein sequence ID" value="ENSMZEP00005013621.1"/>
        <property type="gene ID" value="ENSMZEG00005010244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485675"/>
    <dbReference type="KEGG" id="mze:101485675"/>
    <dbReference type="CTD" id="57610"/>
    <dbReference type="GeneTree" id="ENSGT00940000158257"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000011">
        <property type="entry name" value="RAN binding protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="617" mass="67479" checksum="9E7D9A29AC4717EF" modified="2019-02-13" version="1">MTELGAGSLPLGDPAFNYQEHELNERLKRLYPAVNEEETPLPRSWSPKDKYSYIGLSQNNLRVHYKGHGKNHKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGISLGVAFTDLPPNLYPTVGLQTPGEIVDANFGQQPFVFDIEDYMSEWRAKIHGMIARFPIGERLGEWQAVLQNMVSSYLVHHGYCATATAFARATETMIQEDQTSIKNRQRIQKLVLAGRVGEAIEATQQLYPGLLERNPNLLFMLKCRQFVEMVNGTDSEVRCLTIRSPKSQDSYPGSPCLSPHHGASNTHLHTGGSDSPTCSNGVTPPNKSKSHSSSGSIKYPSASSSASSSSSSSPSSINYSESNSSDSTKSQPHSANSTQETSDSEMEIEAEHYTNGVVEGSSARIMNGTYKHEEILQPDDNSIGNGVTDEVCSHSRQLCGGNQAATERMIQFGRELQALNEQLCQEYGKNTTHKKMLQDAFSLLAYSDPWNCPVGQQLDPTQRESLCSALNSAILESQNLPKQPPLMLALGQATECVQLMARVRSGSCSFARVDNFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVI7</accession>
    <name>A0A3P9BVI7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVI7"/>
    <dbReference type="Ensembl" id="ENSMZET00005014118.1">
        <property type="protein sequence ID" value="ENSMZEP00005013651.1"/>
        <property type="gene ID" value="ENSMZEG00005010277.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282517"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018159018" description="Ig-like domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="102" mass="11618" checksum="40D438384E0B3356" modified="2019-02-13" version="1">NAVLFLLKYFIILFFPGESHRLTCTYSGFSGHSATVWIRQAAGKGLEWIAFIWGESSGSFYSQSVQGRFTISRDNSRQQVYLEMNSLTVEDSAVYYCARQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVJ9</accession>
    <name>A0A3P9BVJ9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVJ9"/>
    <dbReference type="Ensembl" id="ENSMZET00005014449.1">
        <property type="protein sequence ID" value="ENSMZEP00005013978.1"/>
        <property type="gene ID" value="ENSMZEG00005010526.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063509"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.60">
        <property type="entry name" value="Phospholipase B-like, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.20">
        <property type="entry name" value="Phospholipase B-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043040">
        <property type="entry name" value="PLipase_B-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043041">
        <property type="entry name" value="PLipase_B-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043042">
        <property type="entry name" value="PLipase_B-like_dom3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF1">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="512" mass="58431" checksum="83E514BEB8BC6C7F" modified="2025-10-08" version="2">MTAATVYWDPDHKLVKLKEGVMEVEGDAYGFLNDTLSSTGWSVLEIRAGYGETPETDEITFFLAGYLEGFLTAQQMMDHYTNMYPQLITDPKMLDPVQKFMEEQDSWVRQQVNKSSDPLWKHAGFIMAQLDGLQAGVAAWAEKQGKKPLTLFDVQFLNSVGDLLDLIPALVPSSYPSLRDFKLPGMGHCSALIKMLPGYENLLFAHSSWYTYAATMRIYKHWDFHISEPHTATGKLSFSSYPGFLVSLDDFYLLGSGLMMTQTTNVVFNSSLFDTITPNSLLAWQRVRLAHSLAKTGEEWAKTFSMYNSGTYNNQYMVLDRSKVKLGHSLDDGALTVVEQIPSLVEYSDQTQTLRRGYWPSYNIPFHRKIYTMSGYVEMWEQYGEDFSYDLCPRAKIFRRDQCGIKDLESLKRIMRFNDYKKDPYSKGDPCKSICCRKDLRGEDPLPGGCYDTKVTDFHLAGDFRAEAVNGPTTQDGLPPFSWDKFSSISHQGLPQYYNFTFVKMQPILFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY10</accession>
    <name>A0A3P9BY10_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine palmitoyltransferase 1</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Long chain base biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Serine-palmitoyl-CoA transferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Required for adipocyte cell viability and metabolic homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:14762"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:35679"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:71008"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:35680"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:33683"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:65073"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:33684"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:35675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:71007"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:35676"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004575093.1">
        <property type="nucleotide sequence ID" value="XM_004575036.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BY10"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014747"/>
    <dbReference type="Ensembl" id="ENSMZET00005015232.1">
        <property type="protein sequence ID" value="ENSMZEP00005014747.1"/>
        <property type="gene ID" value="ENSMZEG00005011081.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473235"/>
    <dbReference type="KEGG" id="mze:101473235"/>
    <dbReference type="CTD" id="10558"/>
    <dbReference type="GeneTree" id="ENSGT00550000074872"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000049">
        <property type="entry name" value="serine palmitoyltransferase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="20">
        <location>
            <begin position="97"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="473" mass="53227" checksum="DAD37BC25CDC2ED2" modified="2019-02-13" version="1">MATGQQWVLVEMVQAFYEAPAYHLILEGILILWIIRLLFSKTYKLHETYKLTEKEKEELIEEWQPEALVPPVSKDYPTLNYDVVTGPPSHKITINGKDCINFASFNFLGLLDNERVKQKALASLKKYGVGTCGPRGFYGTFDVHLELESRLSKFMKTEEAILYSYGFATIASAIPAYSKRGDIIFVDEAACFAIQKGLQASRSLIKYFKHNDMEDLERLLKEQELEDLKNPRKARVTRKFIVVEGLYINTADICPLPELVKLKYKYKVRIFLEESMSFGVLGDHGRGVTEHFGVNIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPMLAAAAIEALNIMEEDPDVFRVLREKCKHVYNALQGTPGLKLAGVPVAPALHLELERSSGSRESDMKQLRSVVDYCMERHVALTLARCLEKEERFLPPPSIRVVVTIEQTEEDIQKAVACIREAASALLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C141</accession>
    <name>A0A3P9C141_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">G protein subunit alpha 12</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(12) subfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_004568332.2"/>
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        <property type="gene ID" value="ENSMZEG00005011918.1"/>
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        <property type="term" value="C:brush border membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="GPROTEINA"/>
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    <keyword evidence="9 14" id="KW-0342">GTP-binding</keyword>
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    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
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        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        <location>
            <begin position="206"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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        <location>
            <position position="212"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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            <begin position="231"/>
            <end position="235"/>
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        <ligand>
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            <end position="303"/>
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        <location>
            <position position="357"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004635"/>
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            <dbReference type="ARBA" id="ARBA00010405"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015874.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="385" mass="44645" checksum="8D1827837519A7C1" modified="2019-02-13" version="1">MSGVVRTLSRCLLPAEASRDPVGSKERSRERDAAQEREARRRSREIDAMIARERRAIRRLVKILLLGAGESGKSTFLKQMRIINGQEFDQKALLDFRDTIYENILKGMRVLVDARDKLGISWQSCENEKQGMLVMSWEGRVGASGVEPSEFQLYVMALSALWADAGIQEAYTRRSEFQLSESVKYFLDNLDRIGQLSYIPSKQDILFARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMASSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFLNVSIILFLNKTDLLVEKIRTADIRKNFPEFRGDPRRLEDVQAFLVQLFSRKRRNRGKPLFHHFTTAVDTENIRFVFHAVKDTILQENLKDIMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2G5</accession>
    <name>A0A3P9C2G5_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSMZEG00005012071.1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="207" mass="22955" checksum="03BFC50EF7BBF002" modified="2019-02-13" version="1">MREQTLSRLKSQTGLLPGRSLNQYNENHSAADLILTLSFSSSTGMLKRTKYSRLRNDSPTSLEENPQGMLPLKQDLCLDSEFSQLGLGISTHHGPSTLRDFIPRMANIRLQSPISRQGLKGQTDTARGRSISAPTDKPLSRTEWGSGSNERFCTHASLNAPLSTGQNLIHPALLSVLNYCLLSYMGSVEVTQSMRTLDFDTRMQVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2J5</accession>
    <name>A0A3P9C2J5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA-directed DNA/RNA polymerase mu</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="RefSeq" id="XP_004569454.2">
        <property type="nucleotide sequence ID" value="XM_004569397.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2J5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016480"/>
    <dbReference type="Ensembl" id="ENSMZET00005017001.1">
        <property type="protein sequence ID" value="ENSMZEP00005016480.1"/>
        <property type="gene ID" value="ENSMZEG00005012364.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101475122"/>
    <dbReference type="CTD" id="27434"/>
    <dbReference type="GeneTree" id="ENSGT00940000158490"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000003">
        <property type="entry name" value="DNA polymerase mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000004">
        <property type="entry name" value="DNA-directed DNA/RNA polymerase mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000035">
        <property type="entry name" value="DNA-directed DNA/RNA polymerase mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027249">
        <property type="entry name" value="DNA/RNApol_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001726">
        <property type="entry name" value="TdT/Mu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF24">
        <property type="entry name" value="DNA-DIRECTED DNA_RNA POLYMERASE MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000817">
        <property type="entry name" value="DNA_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF501176">
        <property type="entry name" value="DNApol_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00871">
        <property type="entry name" value="DNAPOLXTDT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 13 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000817-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="530" mass="59634" checksum="C0F04C2D2557E3A2" modified="2019-02-13" version="1">MVPLKRRKTLPSDAGNTVSDSSGHKVPNKFSQVVLFLLERKMGASRRFFLSQLGRNKGFQVADVFSESVTHVISENNCGTEVRTWLESQGRGQSLRVHLLDVSWYTESMRAGHPVEITHRHKLQEQQISEAEVALFSVSSYACQRRTTLDNHNSNLTDALSLLAENAELNNEDGRGVAFRRAAALMKALPTQVISMSQLRGLPCLGEHSLRVIKDVLENGVSSEVESTKQSKRYKALKILTGIFGVGAKTADRWIREGIYNLEQLRHSGQTLNRAQKSGLEHYDDLNEPVTKAEADAIGEIVQKAVDSVLTGSQVALTGGFRRGKLTGHDVDFLITHPEEGKEVGLMPKVVAWLESRGFLLYQKTTRNSYLESKDGPARPASNMDRFERCFSIFKLTKGKEQESTQPEEQNDLKTKDVLRPHMQVDTDQQLCELSKNYQMEAASHKIWRAVRVDLVVSPISQFAFAVLGWTGSKLFERELRRWAGHEKNMSLSSHALFDNTQNKYLRATSEEEIFAYLGLEYIPPSERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3Y4</accession>
    <name>A0A3P9C3Y4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3Y4"/>
    <dbReference type="Ensembl" id="ENSMZET00005017518.1">
        <property type="protein sequence ID" value="ENSMZEP00005016978.1"/>
        <property type="gene ID" value="ENSMZEG00005012751.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177186"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF5">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="142" mass="16520" checksum="CD8B1C7F428A26B8" modified="2019-02-13" version="1">MAIVNYSAFIYVFFPYAVVCHGLAVGQISSYYFLVQRPMPWVKAQEFCQKYYVDLAVLTTEEQYFSVLNATPATKVSFWLGLKRQSVSSDWQWVNGEQLGYEHWYRRNNEGCCASLEAMLEKDKNLLARYCKEPHMVVCQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4Z0</accession>
    <name>A0A3P9C4Z0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.33</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Enzyme responsible for the N-acetyl-histidine (NAH) synthesis, which is a major constituent of brain and lens of ectothermic vertebrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57772"/>
            <dbReference type="EC" id="2.3.1.33"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.33" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004574855.1">
        <property type="nucleotide sequence ID" value="XM_004574798.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004574856.1">
        <property type="nucleotide sequence ID" value="XM_004574799.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4Z0"/>
    <dbReference type="Ensembl" id="ENSMZET00005017660.1">
        <property type="protein sequence ID" value="ENSMZEP00005017114.1"/>
        <property type="gene ID" value="ENSMZEG00005012858.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005017663.1">
        <property type="protein sequence ID" value="ENSMZEP00005017117.1"/>
        <property type="gene ID" value="ENSMZEG00005012858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477274"/>
    <dbReference type="KEGG" id="mze:101477274"/>
    <dbReference type="CTD" id="375607"/>
    <dbReference type="GeneTree" id="ENSGT00390000016398"/>
    <dbReference type="OrthoDB" id="8889733at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047981">
        <property type="term" value="F:L-histidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000039">
        <property type="entry name" value="Probable N-acetyltransferase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056483">
        <property type="entry name" value="Hisat_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403">
        <property type="entry name" value="LOC100145250 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47403:SF3">
        <property type="entry name" value="N-ACETYLTRANSFERASE 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24066">
        <property type="entry name" value="Hisat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00052245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="337" mass="38409" checksum="DB15FFC0F00757D9" modified="2019-02-13" version="1">MKIDTSLNMPQLPEALSQAGLQFTVATEEDFDEIMAMSQDIYGGLDYLPTRYTSWLQDTNRTVILARKHGKVIALESVCVIDEGETMLVEGLRVAPQERGKGVAGVLLRFCAELVKSRYPEVKVCRLTRDDKLGPKDFEKYRIITKQGILLMRFRAEDLKLHLSEFGLEGDNESTLSTFCSSPPPVHLDHTAIQQLYLNSDLMHGVLPNATIIQDWQPFKLLPSNMAILLKKEIDWMVDDVSNPTVASLCTFPFRVPIGDDWYYLNIDMFGKDLALARQQFLYHLQRHTATLKGHVMCQMFLDPPLWKAMAEFCHDTLSVELVKEYTEQCVVECDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6B3</accession>
    <name>A0A3P9C6B3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Monocarboxylate transporter 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 16 member 13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012773501.1">
        <property type="nucleotide sequence ID" value="XM_012918047.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012773502.1">
        <property type="nucleotide sequence ID" value="XM_012918048.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024660143.1">
        <property type="nucleotide sequence ID" value="XM_024804375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C6B3"/>
    <dbReference type="Ensembl" id="ENSMZET00005018397.1">
        <property type="protein sequence ID" value="ENSMZEP00005017813.1"/>
        <property type="gene ID" value="ENSMZEG00005013400.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469166"/>
    <dbReference type="KEGG" id="mze:101469166"/>
    <dbReference type="GeneTree" id="ENSGT00940000164450"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000163">
        <property type="entry name" value="Putative monocarboxylate transporter 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF84">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="15">
        <location>
            <begin position="14"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="443" mass="48760" checksum="7ADE74E1625F2EF4" modified="2019-02-13" version="1">MKSRKVEPPDGGYGWVVVMSAFFTMGLTAAVLKNFGHFFIEIQNHFGVQASTTSWVTSTTIAMLHLGAPAASAMTLQFSQRVVIMLGGLLATLGMVLASLDLSLPWLYLTMGILQGTGLSFSWISANSMVSHYFVRWRPIAFAIASSGECVFAVMFSPFFKWLIDTYSWRGALLIIGGLQLNLCVCGALMRPLKKTTRPAQDTKDSLEGDATTLLAKRRTFFQCFLMRKPEFFLYILFAIFSAAGFFIPPLFLVPFASSLGMDKYWPAMILSVLASADLAGRLICGWIANMRLVRNLQLLTMVATLLGVVLLLLPISQNYWAILVFASLYGFLFGCVVAIHVTAIVDIVTLECFDSGLGLFMLLRSIGGFTGPPAAGWLVDYTNNYSVAFYLSGVCLIVSTAFVVLVDRLVHKRREAAEPQVYCAIDQQEDWETAKAESDTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8T1</accession>
    <name>A0A3P9C8T1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Neuroligin 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557391.1">
        <property type="nucleotide sequence ID" value="XM_004557334.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8T1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018311"/>
    <dbReference type="Ensembl" id="ENSMZET00005018902.1">
        <property type="protein sequence ID" value="ENSMZEP00005018311.1"/>
        <property type="gene ID" value="ENSMZEG00005013745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475673"/>
    <dbReference type="KEGG" id="mze:101475673"/>
    <dbReference type="CTD" id="100002407"/>
    <dbReference type="GeneTree" id="ENSGT00940000166430"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000001">
        <property type="entry name" value="Neuroligin 3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000460">
        <property type="entry name" value="Nlgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01090">
        <property type="entry name" value="NEUROLIGIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018294156" evidence="15">
        <location>
            <begin position="19"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="16">
        <location>
            <begin position="61"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="643"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="846"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="874" mass="97806" checksum="D66AC90FF85020EA" modified="2019-02-13" version="1">MSTRAFILDMLFFPFSAASHQGYGGKHHYSTQQVANHCLVWLLGLVLHLTISSCQRVDLKHPIVSTSYGKVRGIRKELNNEILGPVEQYLGVPYATAPIGERRFQPPEAPGSWQEIRNATHFAPVCPQNVHGVLPEIMLPVWFTDNLDAAATYVQNQSEDCLYLNIYVPTEDGPLTKKHDESSMNRPRDEDIRDRRKKPVMLFIHGGSYMEGSGNMFDGSVLAAYGNVIVVTMNYRLGVLGFLCTGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGAACVNLLILSHHSEGLFQRAIAQSGSAISSWSVNYRPQIYTKILAKKVGCTTGDNAELVDCLRRKSFRELVDQDIQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDILLGVNQGEGLKFVDDSEGEDGISAASFDYTISNFVDNLYGYPDGKDILRETIKFMYTDWADRDNSDMRRKTLLALFTDHQWVAPAVATAKLHAEFQSPVYFYTFHHHCQTEARPDWADAAHGDEIPYVFGIPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKSGDPNLPVPQDTTFIHTKPNRFEEVIWTKFSSKDKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHSLHEEIINSITTRLPPGGTSRWKAPHPGTRSTRHPVVSTYPPDPDPDSSERPRYPPFPSETRDYSTELSVTVAVGASLLFLNVLAFAALYYKRDKRHELMQRRHRRLSPQRGTTMGMGVGMGVVGAPPHNDLALSQEEELMSLQMKQQRVELEHGTPLPSRGVHGDLEPLRPPVCPPDYTLALRRAPEDVPLMTANTITMIPSTISSMQPLHPFNTYPPVPAPSTTPVPSHSNNALPHQHSTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8V8</accession>
    <name>A0A3P9C8V8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein heavy chain ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8V8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018725"/>
    <dbReference type="Ensembl" id="ENSMZET00005019326.1">
        <property type="protein sequence ID" value="ENSMZEP00005018725.1"/>
        <property type="gene ID" value="ENSMZEG00005014042.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154620"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000003">
        <property type="entry name" value="Dynein cytoplasmic 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF15">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="391" mass="44680" checksum="D397E865605700FB" modified="2019-02-13" version="1">MDGVEPVLYPLLRRDLIAQGPRYVVQIGDKVIDYNEDFRLFLATRNPSPFIPPDAVSVVTEVNFTTTRAGLRGQLLALTIQQEKPELETEKTRLLQQEEDKKIQLAQLEESLLETLATAQGNILENRELIDSLNQTKASSALIQESLLESHRLQASLDQERDAYLPLAESASKMYFVITDLSKINNMYRFSLASFLRLFQRALQAKKEEENTDARIAALGANLKNMVYEYVCRSLFKADQLMFAIHFVKGMYPELFLENEWDVFTGSIVGEMFKKEVRIQLFLFPSWIDQERHGAVAILKATFPALYQTLCLSDSDLWLSFLQSSHCEQEIPSSIAKKITPFQQLLLVQAVRPDRLQSAMTCFASQTLGKCFRLLLCVLFIFAVHLNIHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9M5</accession>
    <name>A0A3P9C9M5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9M5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018601"/>
    <dbReference type="Ensembl" id="ENSMZET00005019201.1">
        <property type="protein sequence ID" value="ENSMZEP00005018601.1"/>
        <property type="gene ID" value="ENSMZEG00005013945.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162662"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="269"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="82128" checksum="F9493AE6DCD1607F" modified="2019-02-13" version="1">MMTSCGLLTAQNKPVPLKSIEVELEVRDHVATVVSILNYKNKEDKPLEAVFVFPLPGDAAVCHFSAKIGQTQIVAEVKEKQKAREEYDDALSSGQQAFLLEESDQSPDIFSLSVGSLPPGESASIRLEYVAELAVQADDGLRFCLPAVLNPRYQPQGGLSSVGLVPYSLSFSARVSSPRPISKVESNCSLDPLQDLNTDQTQATVKLAAGHKFDRDVELLIYYKDAHQPTAVVEAGQASAEPGSLMGDPVVMVSLYPEFPQSAMASCGEFVFLMDRSGSMSNTRIRSAKDTLLLLLKSLPMGCCFNIYSFGSRYEHIFPKSVEYSQQTMEEALNTVEQMEANLGETEILEPLKHIYNQPCIPSQLRQLFVFTDGEVRNTKEVIDLVKKNSDSHRCFSFGIGEGASSALINGMAKEGGGHTQFITGTDRMQAKVMQSLRFALQPVVVDISVTWDLPKEVSVTVLSPPITALFQGQRSLIYAQLSGQSSEAAEGCVTVKYSLAGHPSENQLHFSLRPAEDTGLTVHRLGARTLIRSLEMEEREHRGQQVGGVKEKVVQLSVQSGVSSSFTAFIAVNKDNSEMIQGPLVRRNVPTPCEFLPKAKLKVSHSSEAKMVEKAMTGHLMFSYYFIFVLFSLPAAVHEHLSRDPLLQLVSLQEASGCWLLDPALATALGKTSKEVKKSKPEKVGFLWATVLALIWLHAFKMDAKDEWELLAMKAASWLRAQNAPCESECVDAGNILLGSSVKKEALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAA7</accession>
    <name>A0A3P9CAA7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_004561162.2">
        <property type="nucleotide sequence ID" value="XM_004561105.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAA7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018984"/>
    <dbReference type="Ensembl" id="ENSMZET00005019592.1">
        <property type="protein sequence ID" value="ENSMZEP00005018984.1"/>
        <property type="gene ID" value="ENSMZEG00005014228.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101468320"/>
    <dbReference type="GeneTree" id="ENSGT00940000156483"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF28">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="167"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="509" mass="55841" checksum="5000E2C783507102" modified="2019-02-13" version="1">MSQIQHAALDQQGRYNQICTRGGSCPPPADGSEPAHCPGHRSRSPRKKWQVFPGRNRFYCDGRIMMARQTGVFYLTLVLILLTCGLFFTFDCPFLASNLTPAIPAVGGVLFIFVMGMLFRASFSDPGILPRATPDEAADLERQIDSAGCSRPPPRTREVLINGQAVKLKYCFTCKIFRPPRASHCSLCDNCVERFDHHCPWVGNCVGRRNYRFFYLFILSLSLLTVFIFAFVITHVILRSNQTGFLGALKDSPASVLEVVVCFFSIWSIVGLSGFHTYLISSNQTTNEDIKGSWSTKRGKDNYNPYSYGNILTNCCAALCGPLPPSLIDRRGLIQSGTPQTVSQSNGTSNSSYASTQLHSNMCDQDQCIQSTKFVLQAATTPLLHSDPVVLAPLPGKTTTLGGPCAYLAPAQPSLPSCGGDVLMLRDAAVDSRCHHHLHLHHHHHHHHFVSPEETPCATPQGALPCPAHLHLHHQPHPAIPSPIALYDPASQDALHEDSVRGLVKLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAW4</accession>
    <name>A0A3P9CAW4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemokine (C-C motif) ligand 25b</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014268012.2">
        <property type="nucleotide sequence ID" value="XM_014412526.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAW4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019433"/>
    <dbReference type="Ensembl" id="ENSMZET00005020061.1">
        <property type="protein sequence ID" value="ENSMZEP00005019433.1"/>
        <property type="gene ID" value="ENSMZEG00005014587.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:106676255"/>
    <dbReference type="GeneTree" id="ENSGT00900000141362"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00169">
        <property type="entry name" value="Chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF186">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 21-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018333413" evidence="2">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="3">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="90" mass="10663" checksum="A112AED898D90FB1" modified="2019-02-13" version="1">MKFHAFVFMLLFLCTYLSLAQGSYANCCLGYVREIKKKRNLVSYTMQETDVDCNIRAVLFKKKKRKQPVCANPNDHWVQKEMRRLDLMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAY3</accession>
    <name>A0A3P9CAY3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Pachytene checkpoint protein 2 homolog</fullName>
            <shortName evidence="10">TR-interacting protein 13</shortName>
            <shortName evidence="10">TRIP-13</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Thyroid hormone receptor interactor 13</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thyroid receptor-interacting protein 13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004541502.1">
        <property type="nucleotide sequence ID" value="XM_004541445.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004541503.1">
        <property type="nucleotide sequence ID" value="XM_004541446.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004541504.1">
        <property type="nucleotide sequence ID" value="XM_004541447.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAY3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019445"/>
    <dbReference type="Ensembl" id="ENSMZET00005020073.1">
        <property type="protein sequence ID" value="ENSMZEP00005019445.1"/>
        <property type="gene ID" value="ENSMZEG00005014596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475492"/>
    <dbReference type="KEGG" id="mze:101475492"/>
    <dbReference type="CTD" id="9319"/>
    <dbReference type="GeneTree" id="ENSGT00390000017432"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19508">
        <property type="entry name" value="RecA-like_Pch2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000662">
        <property type="entry name" value="Pachytene checkpoint protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0896">Oogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="162"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="423" mass="47712" checksum="AD4C7A0CCADD1EFB" modified="2019-02-13" version="1">MEDDRMETGNLTPKIHVEVHVKSDSTAKRSEVKMHVQSLLNCHSMVFGNYAWTEFDDDFLQKHVASVVIADLEEIVTQPLDLKNCCVSFHIFTLSEDGPSMLTLEEDEELSAANHWLLPAAEFHGIWESLVYETGVKTQLLDYVTTTIYFSDKNVDSNLISWNRVVLLHGPPGTGKTSLCKALAQKLSIRLSSRYLYGQFVEINSHSLFSKWFSESGKLVTKMFQKIQQLIDDKDALVFVLIDEVESLTAARNACQAGTEPSDAIRVVNSVLTQLDQIKRHSNVVILTTSNVTEKIDLAFVDRADIKQYIGPPSEKGIYNIYLSCLEELMKCQIIYPRQQLFTMFELETMGFAKSEVSEHSLNLRNIAIKSKGLSGRALRKLPFIAHALFVKTPTVTLERFLEAMGQAVEKQKEEKANLVNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CB99</accession>
    <name>A0A3P9CB99_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573803.1">
        <property type="nucleotide sequence ID" value="XM_004573746.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CB99"/>
    <dbReference type="Ensembl" id="ENSMZET00005020202.1">
        <property type="protein sequence ID" value="ENSMZEP00005019573.1"/>
        <property type="gene ID" value="ENSMZEG00005014687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484972"/>
    <dbReference type="KEGG" id="mze:101484972"/>
    <dbReference type="GeneTree" id="ENSGT00940000158225"/>
    <dbReference type="OrthoDB" id="432835at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03165">
        <property type="entry name" value="NET-5_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF364">
        <property type="entry name" value="TETRASPANIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="239" mass="26769" checksum="D87D8C816078CE62" modified="2019-02-13" version="1">MARGCICCVKYMLFLFNLLFWLGGCGLLGVGVWLSVSQGSFATLSPSFPSLSAANLIITLGTVVMVTGFLGCLGAIKENKCLLLSFFIVLLIILLAELILLILFFVYTDKVSENARQDLKEGLVLYNTDNNAGLRDAWNTIQGEWKCCGVTNHRDWHTAFHDDVVPDRCCQQVYPDCGRNTSNVFWTRGCYEKVEEWLDDNKHLLGTIAMCVLVIQLLGMAFSMTLYQQIHRAGKKYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBR2</accession>
    <name>A0A3P9CBR2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fucolectin-4</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012777013.2">
        <property type="nucleotide sequence ID" value="XM_012921559.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBR2"/>
    <dbReference type="Ensembl" id="ENSMZET00005020376.1">
        <property type="protein sequence ID" value="ENSMZEP00005019745.1"/>
        <property type="gene ID" value="ENSMZEG00005014821.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005020380.1">
        <property type="protein sequence ID" value="ENSMZEP00005019749.1"/>
        <property type="gene ID" value="ENSMZEG00005014821.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:105941118"/>
    <dbReference type="GeneTree" id="ENSGT01060000248575"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF8">
        <property type="entry name" value="SI:CH211-215K15.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044597160" evidence="10">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="11">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="11">
        <location>
            <begin position="173"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="315" mass="34661" checksum="2858F55369F51948" modified="2019-02-13" version="1">MSFSRASLLLLFVQMSSVFTYQNVALRGKATQSRLINPGEWDGFAAAGNAIDGNRKSRFNYGSCSHTATEANPWWRVDLLESYIITSMIITNREDCCEERINGAEIHIGNKLQDNGAANPRVAIISSIPAGSSHTITFSNRVEGRYVTVLLPGSNRILTLCEVEVYGYHAPTGENLALQGKATQSSVQTLGLAYNAIDGNRNSDPEKGSCTQTNYDNIPWWRLDLRKTHKVFSVKIVNSDSDPERLNRAEIRIGDSLDNNGNSNPRCAVITSIPAGGIQEFQCNGMDGRYVNVVIPGREEYLSLCEVEVYGSVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJA6</accession>
    <name>A0A3P9CJA6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004568632.1">
        <property type="nucleotide sequence ID" value="XM_004568575.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJA6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021916"/>
    <dbReference type="Ensembl" id="ENSMZET00005022633.1">
        <property type="protein sequence ID" value="ENSMZEP00005021916.1"/>
        <property type="gene ID" value="ENSMZEG00005016426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468355"/>
    <dbReference type="KEGG" id="mze:101468355"/>
    <dbReference type="CTD" id="56957"/>
    <dbReference type="GeneTree" id="ENSGT00940000159172"/>
    <dbReference type="OrthoDB" id="10064699at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22772">
        <property type="entry name" value="OTU_OTUD7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14347">
        <property type="entry name" value="UBA_Cezanne_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000017">
        <property type="entry name" value="OTU domain-containing protein 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF8">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="17">
        <location>
            <begin position="177"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="18">
        <location>
            <begin position="877"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="434"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="672"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="786"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="920" mass="100792" checksum="FCD8B588FC862A7B" modified="2019-02-13" version="1">MTVDMDAVLSDFVRSTGAEPGLARDLLEGKNWDFTAALSDFEQLRQVHAGNLSYSFTEERTYLAPEKEMARVGRPILHRQDEVVQATEKRLSRGISHASSTIVSLARSHVSSTGGSSNEPLLDTPLCTFQLPDLTVYRDDFRNFIERDLIEQSMMVALEQAGRLNWWTKVVSNCQSLLPLATSGDGNCLLHAASLGMWGFHDRDLMLRKSLYALMDHGLEREALKRRWRWQQTQQNKESGLVYTEEEWQKEWNELLKLASSEPRIHYSTNGTNGVESSDEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPSAKCHRSPLVLAYDQAHFSALVSMEQKDSSKEQVVIPLTDSEHKMLPLHFAVDPGKDWEWGKDDTDNVMLASVALSLEAKLQMLHSYMTVTWLPLPCEQAPLAQPESPTASAGEDARSPPDSGESDKESVSSSSNGNGDTTTGSTVNGGGSLAKNSSSSSSSSSSSGSAGKDKTKKEKDKDKDKKRADSVANKLGSFGKSLGSKFKKNVGGLMPGKNVGAGGAKQEGGEKKKGSFRGRKGSKDSSPSAHASEDSGKGSPSSGSERLNGAGSSMSSSGGSSTESEPYKYSADVKVSLGILRAAMQGERKFIFASLLTTSNRQPFQEEMIQRYLADAEERFRAEQEQQRREAERKSIANSLQPPKKEVVGCSELSYRPYEPKEELSENSSPSFNTLKLSPLSPSMYSAVVPIPRPSFIDQPLPAAPLTQHLHMHSYVDNRRQLAGGSSAISYPGLPSYATLPRHGPTAQPPSHPQYNNSQGPSSLSPSRLAPSYPPEFDPPDYPGAELTTGNYTNGFRDMSSNLDCRNGQPPVRHYSLGSASGLAGLQSSRCRTPNCNYYGHPETGNYCSYCYREELKKRETEPAIHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKU5</accession>
    <name>A0A3P9CKU5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TraB domain containing</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004570843.1">
        <property type="nucleotide sequence ID" value="XM_004570786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKU5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022948"/>
    <dbReference type="Ensembl" id="ENSMZET00005023701.1">
        <property type="protein sequence ID" value="ENSMZEP00005022948.1"/>
        <property type="gene ID" value="ENSMZEG00005017184.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464483"/>
    <dbReference type="KEGG" id="mze:101464483"/>
    <dbReference type="CTD" id="80305"/>
    <dbReference type="GeneTree" id="ENSGT00390000009067"/>
    <dbReference type="OrthoDB" id="48306at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="359" mass="39436" checksum="C2FC900C013DC40D" modified="2019-02-13" version="1">MDQENNSEDDSVGPSGDGMPCLPPDLSDGEAVELLWQLRAQRRQSSPELPETVSRLTAPDGSILYLVGTAHFSDSSKKDVATTIRAVQPDVVVVELCQYRVSMLKMDENTLLKEAKDINLDKVQQAIKQNGVMSGLMQILLLKVSAHITEQLGMAPGGEFREAFKEAGRVPFCKFHLGDRPIPVTFKRAIAALSLWQKARLAWGLCFLSDPISKEDVEKCKQKDLLEQTMSEMIGEFPALHKTIVAERDIYLTHTLRQATRCVESPPNAQKVPAVVVGVVGMGHVPGIERNWDKQLNINEIMSVAPPSRVGWVLCAVIKGVMMGMLGYACYRVGGSLGRALLSLPPVRSLLETLRPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLX1</accession>
    <name>A0A3P9CLX1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Aminopeptidase</fullName>
            <ecNumber evidence="23">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 23">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 23">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="23"/>
    <dbReference type="RefSeq" id="XP_004544542.1">
        <property type="nucleotide sequence ID" value="XM_004544485.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLX1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022826"/>
    <dbReference type="Ensembl" id="ENSMZET00005023578.1">
        <property type="protein sequence ID" value="ENSMZEP00005022826.1"/>
        <property type="gene ID" value="ENSMZEG00005017088.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465238"/>
    <dbReference type="KEGG" id="mze:101465238"/>
    <dbReference type="CTD" id="64167"/>
    <dbReference type="GeneTree" id="ENSGT00940000162653"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000007">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000003">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF239">
        <property type="entry name" value="ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3 23" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 23" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 23" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="24" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 21 23" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018002410" description="Aminopeptidase" evidence="24">
        <location>
            <begin position="20"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="27">
        <location>
            <begin position="61"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="25">
        <location>
            <begin position="282"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="26">
        <location>
            <begin position="604"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="22">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="945" mass="107612" checksum="97FA637E965A5438" modified="2019-02-13" version="1">MVSARLLVLSLFSASLVGSQPTESSQQVSSPPAHPAGEPSLSIDNLSFPWSRLRLPKYIIPLHYHLLLHPNLTSLSFTGSVQIQIDVQNNTNWVVLHSKGLQISKATILDQNLTHLSEQVLPVLHNPSHEQIGIFSPRVLSSGQKYFLYIEFGAELAEGFYGFYKSTYRTSTGETRTLASTHFEPTSARMAFPCFDEPSFKANFSVRIRRRPEYISLSNMPVIKTVEVSGDLLEDQFAPSVQMSTYLVAFVICDFKSVTGTTSSGVQVSIYAAPEKWQQTHYALEVAVKMLDFYEEFFNIRYPLPKQDLIAIPDFQSGAMENWGLTTYRETSLLYDPLTSSVSDKLWVTMVIGHELAHQWFGNLVTMEWWNDIWLNEGFARYMEYISVEATYPDLKVEEYLLHTCFAAVGHDSLNSSRPISSPAENPTQIKEMFDTVSYDKGACVLHMLRHFLTDEVFQRGIVRYLRKYSYKNAHNQDLWDSLANTCSEEDFISGKHCYSSSQASKNAYLFAGEHLNLTAMMNTWTLQKGIPLVTVTRKGARLLLRQDRFLKTVLPSDPQWSTLQKGFLWHIPLTYKTDSSSTIHRHLMTSPTDSIHIGEEASWVKVNSDMTGYYMVHYEDGGWDVMTKLLSENHTALSYKDRTHLIHNAFQLVTAGHLPLNKALDLIGYLLLETHTVPLLQGLGYLEAFYHLVEKRDESVLTHNLGAYILRFFRAIIDQQTWSDSGTVSERRLRTEVLSLACHLDDPPCVKRARQYFSDWLQSNGTLNLPTDVAETVYSVGAQDDHGWASLLHTYKISLSEAQKHKILYALASSKDTSKLEGLLELGLEGKVIRSQDLSTLILMVARNPKGHYLAWDFVKKNWDTLVQKFQLGSFCIRNIIIGTTSQFSSPEELTEVQSFFESIKEQASQLRATQIALDNVLKNVRWVQRNLETLRKWLNEQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLX8</accession>
    <name>A0A3P9CLX8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cystine/glutamate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Amino acid transport system xc-</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 7 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">xCT</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)</text>
            <dbReference type="Rhea" id="RHEA:70995"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-acetyl-L-cysteine(out) + L-glutamate(in) = N-acetyl-L-cysteine(in) + L-glutamate(out)</text>
            <dbReference type="Rhea" id="RHEA:74567"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:78236"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)</text>
            <dbReference type="Rhea" id="RHEA:71191"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc; this interaction mediates cell membrane localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574149.1">
        <property type="nucleotide sequence ID" value="XM_004574092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLX8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023343"/>
    <dbReference type="Ensembl" id="ENSMZET00005024108.1">
        <property type="protein sequence ID" value="ENSMZEP00005023343.1"/>
        <property type="gene ID" value="ENSMZEG00005017476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487639"/>
    <dbReference type="KEGG" id="mze:101487639"/>
    <dbReference type="CTD" id="23657"/>
    <dbReference type="GeneTree" id="ENSGT00940000166427"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015811">
        <property type="term" value="P:L-cystine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043067">
        <property type="term" value="P:regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000027">
        <property type="entry name" value="cystine/glutamate transporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF323">
        <property type="entry name" value="CYSTINE_GLUTAMATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="494" mass="54381" checksum="AE7A20DD88A4A8FE" modified="2019-02-13" version="1">MTGSSASAHRETAANGHKASSNGTELKREDGKVELGKKVTLLRGISIIIGTIIGAGIFISPKGILKHSGSVGVSLLVWIACGVLSLFGALSYAELGTCMKKSGGHYTYIMEAFGPQMAFIRLWADLIAIRPAGMAVISLAFGQYILEPLFMPCGIPPLAVKLATAIGLTSVMYLNSMSVTWTARIQIFLTVSKLLAIAIIIVPGMYQLFKGETRHFENAFDLSNVQLSGMPLAFYSGMYAYAGWFYLNFVTEEVDNPARTVPLAICISMAIVTSCYVLTNVAYYTVMSAEELLASSAVAVTFAERLLGNFSIAVPVFVALSCYGTMNGCVFALSRMFYVASREGQLPEVLSMIHVRRHTPLAAVLIMYPMTMLQLLVGDIYSLLNFMSFLRWLFIGVVVLGLIYLRYTKPDLPRPFKVPLFFPVVFCITCFFMVFLSLYSDPVNTGIGFAISLTGIPAYYIFIYFNHRPKWLQRTLDSFNRTLQIILEVVPADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRS6</accession>
    <name>A0A3P9CRS6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear receptor-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May regulate apoptosis of neural progenitor cells during their differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004552019.1">
        <property type="nucleotide sequence ID" value="XM_004551962.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CRS6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024774"/>
    <dbReference type="Ensembl" id="ENSMZET00005025583.1">
        <property type="protein sequence ID" value="ENSMZEP00005024774.1"/>
        <property type="gene ID" value="ENSMZEG00005018504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465750"/>
    <dbReference type="KEGG" id="mze:101465750"/>
    <dbReference type="CTD" id="562626"/>
    <dbReference type="GeneTree" id="ENSGT00940000160430"/>
    <dbReference type="OrthoDB" id="1034557at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000098">
        <property type="entry name" value="Nuclear receptor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000266">
        <property type="entry name" value="nuclear receptor-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="505" mass="57610" checksum="84A05D2E7103E4D9" modified="2019-02-13" version="1">MTMSVPERKSGSEGKEEESEDESEILEESPCGRWQKRKEQVSQGNVPGVESASLAMDTEEGVEVVWNEVLFLDKKVFKAQEEKIKEMFENLMQVEHPNIVKFHKYWLDMKESQARVIFITEYMSSGSLKQFLKKTKKNHKTMNVKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSVWHRLFVNVFPDASVHSKARQHRDEQRNLHFFAPEYGAGEDGYAIDIFSFGICALEMAVLEIQANGDSAVSKEAIVNAGQSLEDPLMREFTQSCLHHDSKLRPTAHDLLFHRVLFEVHSLKLLAAHCLINNQYLLPENCVEEKTKSFDPNAVMAEIKHEDRQGVQLKYSHVSPLELDKFLEDVKNGIYPLMNFASTRPHPVPRALSLSQEQVETVKTPTPEPQETETRKVVQMHCNLESNEEGTKTHLSLFLKMDDKLHRQLSCDILPTDTSKDLASELVHYAFINEEDSEKVAGFLENAIKQHRVRALASGSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CS45</accession>
    <name>A0A3P9CS45_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005025180"/>
    <dbReference type="Ensembl" id="ENSMZET00005025999.1">
        <property type="protein sequence ID" value="ENSMZEP00005025180.1"/>
        <property type="gene ID" value="ENSMZEG00005018789.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013680"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="12">
        <location>
            <begin position="1313"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="10">
        <location>
            <begin position="1640"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="920"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1421"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1889"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1431"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1460"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1915"/>
            <end position="1926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2049" mass="224877" checksum="A296D6E73613384C" modified="2019-02-13" version="1">MTTSANWVANGASLEDCHSNIFSLAELTGIKWRCYRFSSGGEYGPVISAPAQDDPVLRSFMRCVQSNLLCVWRRKIKPDAKELWIFWWGEEPNLTGVIHQELEVGEEGLWECGLSYECRTLLFKAIHNLLERCLTDKGFVRIGKWFFKPHELEEKSLGNTEHLSCSFSFFLHGESNVCTSVEIAQHQPAYHITEHHIRLAQTSVTPVQVILSPYGLSGTLTGQAYKMSDPAVRKLMEEWSYFYPMVLQQKELGGEKEKEETSQAYDRNSHVAVEVVVGGVRMTYPSAFVLIAQGDLPVEQPPPVPTAQGLNKELNHCSVPLTPPTSPEQPCSADSGFVTSASSVPTPDSSMSITSISPKHSGKKLTCQVVHQAWRECYLNQPQHSTEVTPRKEVPNGVTTWDFNDLGARAPCSCSRYSRIAPNANPTQSSGPSLYTPSLPKHKTSDKTEKGDKQSKRPAVIPFHHRLSVTQESPLEQDSPGGPSSSLATLPTCKYSKPHSNGRKAPESLLHSPVSPLPPTLSPHPRVQDPEAMDGPVDMPACQDGASGLGVITSETAVYAALLRQRESGAGWWRGFRTPRTDKTDFRPSELPIDKLEEVTTDTTIEGASLKRLYAQAHKRFKLSEERVRQHIQTLGLFQQPGVEALRDNGDDPYDFKEGDIEYTFSTSKRLKGQGREPIVLFSLTMFCVVLDESGQDDGAAKTNPSLTREIDLVVNISDLDNILDEDDEDPGTVYPNQHSTKVPVSTEDRPIGKEGRVAVPYPSTVADLQRMFPTPPSLEQHPAFSPIMTYRDTPSQEPPAPTGPADHLPAAASTQLTEHRMEVEDDIGSPRQEDIKVRRSGSSMFAPLACLPSQNLPPLKIPEQCYYRPSWSLLPKMEHFPTVMHPQNSAFTKDGYINIPSVPLADQDYVQMSGAAASTSTTTGILPSPATPRFSVPTPRTPRTPRGINTASSGQGSVKQDGTELSSPVSTPSTSLPLSSVEPLARPGPSLPEAHSLYTILLLSDSVLSVFKDRNFDSCCICACNQNVKGADVGVYIPDSTGEDQYRCMCGFSAIVNRRLALGTGLFLEDELDIFGRTSEVGRAAERRLALSRRDPTMGDSKAKRPQDAAPASPAVMVLLQEQCSHPISSLASLHFPLSCSCHGRKGALLQSWMSEKQWADGSDACTACYNALEQGLQYVDNPTGGKVDLSVVRSTALHSWPHTNVVDMSMLSSQDMVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTVLLGYDRERDFLALSPLALPFWEKLLLEPYGGQRDVAYMVVCPNSPSLLSAARSFFLELSAVYETCRLGKHRPLAKVSRDGIVRVGEDVEKEKLEELDVDQWLTGPWVGQQHTDNLNKLKLYAYACKQQLGPQLSALPLDSSLLLPPKAQPPVNNTSSAQPSSSTQGEQTTGGASSVNASAPTGATAGPTEEIQGGASDSKGPPSSTPPANTPAENPELSSEQSRIGIPTVADSVDSHANPPAIVIYIVDAFLKGDEVESSSIWLLGLLRCYTEMLQTLPETTRPALVLQVVPCQYLLQPASGESHLYLQHLRSLAFSCYSQCRRLLPQQTHIKSLTGFGPVSTVSSVLKSPEHPSPLQLYTPPFVLGPSRPKQPEPGEIWAELPPKYNVLFVGYCLSHDQRWLLVSCTDQQGELLETCIINIDVPNRARRPKASARKMGLQKLWEWCIGIIQMTSLPWRIVIGRLGRLGHGELKDWSSLLGEHSLHSIGRQLREACRMCGISAADSPTILSACLVALEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSSTTQLASSSYQTEDNNDDMFDLPFPDELENDIGIGIMLNLHSSPNTSPVPSPGSPSGMGMGSHFQHTRSQGERLLSRDNPPEELKQQPLALGYYVSTAQANGLPHWFWASCPQAEKQCPLFLKASLHHHISITQSDENVSEKTKRAPHPLDSKTTSDVLRFVLEQYNALSWLTCTPATQDRQSCLPVHLAILVQMYNAILNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSM8</accession>
    <name>A0A3P9CSM8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable G-protein coupled receptor 173</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004570979.1">
        <property type="nucleotide sequence ID" value="XM_004570922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSM8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024811"/>
    <dbReference type="Ensembl" id="ENSMZET00005025620.1">
        <property type="protein sequence ID" value="ENSMZEP00005024811.1"/>
        <property type="gene ID" value="ENSMZEG00005018529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475032"/>
    <dbReference type="KEGG" id="mze:101475032"/>
    <dbReference type="CTD" id="54328"/>
    <dbReference type="GeneTree" id="ENSGT00890000139436"/>
    <dbReference type="OrthoDB" id="6129346at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15217">
        <property type="entry name" value="7tmA_SREB3_GPR173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000074">
        <property type="entry name" value="probable G-protein coupled receptor 173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051509">
        <property type="entry name" value="GPCR_Orphan/Phoenixin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19268">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19268:SF4">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 173-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="60"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="394" mass="44177" checksum="E4A12013F0780F4A" modified="2019-02-13" version="1">MGGGAFGMANGNESSEGPVGPMAAVVATAEGMVADSSSSVISTYIKLVLLGLIICISLVGNLVVSLLVLRDQALHKAPYYFLLDLCLADSIRSAICFPFVLVSIKNGSAWTYSVLSCKVVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCVAVVCMVWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLILATHVVYMKLLLFEYKHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNLHNQNRRLLGMEEFKAEKQLGRMFYVITLLFLVLWSPYIVACYWRVFVKACTIPHRYLSTTVWMSFAQAGVNPIVCFFLNKDLKKGLLSHLPACCRTKPHLPREPYCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSP4</accession>
    <name>A0A3P9CSP4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dixin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Coiled-coil protein DIX1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">DIX domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DIXDC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012778091.1">
        <property type="nucleotide sequence ID" value="XM_012922637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSP4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025099"/>
    <dbReference type="Ensembl" id="ENSMZET00005025916.1">
        <property type="protein sequence ID" value="ENSMZEP00005025099.1"/>
        <property type="gene ID" value="ENSMZEG00005018735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466931"/>
    <dbReference type="GeneTree" id="ENSGT00950000182903"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21213">
        <property type="entry name" value="CH_DIXDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000054">
        <property type="entry name" value="Dixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000003">
        <property type="entry name" value="Dixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF39">
        <property type="entry name" value="DIXIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 17" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="20">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DIX" evidence="21">
        <location>
            <begin position="550"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="519"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="374"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="638" mass="71137" checksum="19EDB2FCBB724B20" modified="2019-02-13" version="1">MIASLSRGSLMDEVLHGGFNEQQLAAYVSWVNSQLKRKPGLKLIADLRHDLQDGVVLTQLIEIVAGEVLEGVYAAPQNKEESRKNVEEVLRFISSRHIRMPHISARDIVDGNLKSVMRVILALAAHFKPTANHRNASGSGRRLTRGHASHNPLSTVALAQGAAATLASARHDASLPTHTARLHSGCGLDGEKSVCVRALVEQYERGAPDEQDNPQHSSSVSPLSSPRAPPSSHSDRQEQDQEQQQSSAESSQVAVEMAWGDSLNDTLEKEVQETRKMVSALQALLLRGSLPEDEQDASLTLEQGNTSEQQLVVIRSRLDQSMEEAQELKRELLCCKQEVRSLQGVKDAQQQRLCTQEALILQMKQELLRASMTKDELDSKNAELQWKLEECNRLWAECKKEVAQKDRLLQQLKHKLEESQDMQNELQRELEHKNSMLQELMSRDPQEIPTSAENNGCSYPGIPAPSVSGQADEVQLLRDALRSLRNNFRDHDPQHHTLDTLEQGIVSLIDRLHVLHTQRGRGKSPRCKAQHGDLDSSSSTNNCQSHSGSSSSTKILYFTGKSPTPSMITIPKRLGEVTLKDVKAAVDREGNYRYHFKALDPEFGTVKEEVFLDEAIVPGWEGKIVAWLEEDCGEERPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CTQ5</accession>
    <name>A0A3P9CTQ5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Armadillo repeat containing 10</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CTQ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025760"/>
    <dbReference type="Ensembl" id="ENSMZET00005026593.1">
        <property type="protein sequence ID" value="ENSMZEP00005025760.1"/>
        <property type="gene ID" value="ENSMZEG00005019219.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165477"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006911">
        <property type="entry name" value="ARM-rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051303">
        <property type="entry name" value="Armcx_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15712:SF23">
        <property type="entry name" value="ARMADILLO REPEAT CONTAINING 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15712">
        <property type="entry name" value="ARMADILLO REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04826">
        <property type="entry name" value="Arm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo repeat-containing" evidence="7">
        <location>
            <begin position="92"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="264" mass="28705" checksum="1E9AFD20D5C57918" modified="2019-02-13" version="1">MGDITPRFGNMKALLGLVAGAGASYGIYKLISFKRNKKNATGENPGVKGSQQSEVKIQPGSLLARVSGLDVICPRPADTASGDIIHQSPDNLEPQHLKMLLSCLQTSNNPSDRCRILLTLGNSAAFTVNQNLIREFEGIHIIAGFLSDPAPEVRVQTLNALNNLCMNIQNQEQIKVYVPQVLELIEMSPVNSDLQLGALRLLTNLSVTDKHQHLLKESVTLLLSLLVVSNEALQVQTLKVLVNLSSNPDMMDDIVQAQVRPKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUJ9</accession>
    <name>A0A3P9CUJ9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Scaffold protein ILK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ILK-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ILK-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Inactive integrin-linked kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">p59ILK</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550097.1">
        <property type="nucleotide sequence ID" value="XM_004550040.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004550098.1">
        <property type="nucleotide sequence ID" value="XM_004550041.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUJ9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026050"/>
    <dbReference type="Ensembl" id="ENSMZET00005026889.1">
        <property type="protein sequence ID" value="ENSMZEP00005026050.1"/>
        <property type="gene ID" value="ENSMZEG00005019426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477640"/>
    <dbReference type="KEGG" id="mze:101477640"/>
    <dbReference type="CTD" id="3611"/>
    <dbReference type="GeneTree" id="ENSGT00940000155956"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14057">
        <property type="entry name" value="PK_ILK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000187">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000050">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000245">
        <property type="entry name" value="Integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035692">
        <property type="entry name" value="PK_ILK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF57">
        <property type="entry name" value="INTEGRIN-LINKED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="16">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="193"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
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            <dbReference type="ARBA" id="ARBA00030970"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049752"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="452" mass="51276" checksum="3A7C299A4E96FF13" modified="2019-02-13" version="1">MDDIFTQCREGNSVAVRLWLDNTENDLNLGDDHGFSPLHWACREGKNGVVDMLIMRGARINVMNRGDDTPLHLAASHGHRDIVAKLIQCKADPNTVNEHGNTPLHYACFWGQDEVAEDLVASGAQVCICNRYGQTPLDKGKPHLRQLLQEKAEKMGQSLIKVPYKETFWKGTMRTRPRNGTLNKQAGIDYKQLSLLAKINENQSGELWQGRWQGDEIVVKVLQVRDWTTRKSRDFNEEHPKLRIFSHPNILPVLGACQSPPSPHPIIITHYMPYGSLYNILHQGTTLVVDQSQAVKFALDIASGMAFLHTLEPMVSRLYLNSKHIMIDEDMTARISMADAKLSFQCPGRMYSPAWMAPEALQKKPEDINRRSADMWSFAVLLWELVTREVPFADLSHMEIGMKVSLEGLRPTIPPGISPHICKLMRLCMNEDPAKRPKFDMIVPILEKMQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUK0</accession>
    <name>A0A3P9CUK0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDAN1-interacting nuclease 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUK0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025496"/>
    <dbReference type="Ensembl" id="ENSMZET00005026322.1">
        <property type="protein sequence ID" value="ENSMZEP00005025496.1"/>
        <property type="gene ID" value="ENSMZEG00005019029.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018465"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029404">
        <property type="entry name" value="CDIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661:SF1">
        <property type="entry name" value="CDAN1-INTERACTING NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661">
        <property type="entry name" value="SIMILAR TO CDNA SEQUENCE BC052040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14811">
        <property type="entry name" value="TPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="289" mass="33476" checksum="ECC0A4BF7FB3B8DC" modified="2019-02-13" version="1">MRLSRAEYKEIVRWTEKLRPTRRCMKILKDKFPSHSRSTLLSIFSLEYQKWIKRTFSRHHVPDVIESYYQRYLSEAKAQPTAPVLLELANEVDLSPALMARIILDRFLQGQDGGMPSKSVLNSMLKEPSSIPDQILASNVYQCTINDCCYGPLVDCIKHAIGHEHEVLLREKLNEKNLSFLDENHLRTMGYDKTPDIILEVPVAVEGHIVHWIESKASFGDDQSHQTYLNEQFWSYWNRFGPGLVIYWYGFIGDLDCQRDRGILLKDCFPTDIVTLCHATFVSFLYGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVR9</accession>
    <name>A0A3P9CVR9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004560010.1">
        <property type="nucleotide sequence ID" value="XM_004559953.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVR9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026428"/>
    <dbReference type="Ensembl" id="ENSMZET00005027283.1">
        <property type="protein sequence ID" value="ENSMZEP00005026428.1"/>
        <property type="gene ID" value="ENSMZEG00005019715.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485003"/>
    <dbReference type="KEGG" id="mze:101485003"/>
    <dbReference type="CTD" id="55650"/>
    <dbReference type="GeneTree" id="ENSGT00390000013174"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="503" mass="56418" checksum="E1E079EC5E9C9840" modified="2019-02-13" version="1">MDVRAVLEFATVTRGLSLVLQAVLNAAIPDHDADAFRPPRTEDYLYLDSMVEWLFGGLSHWDAEHFLFIAERGYLYEHNFAFFPLFPVILRGLAETLLWPLSSWLSVRGRLLIAVALGNSALFLLSAVALHALSRIVLQDRRLALLSSLLYCITPANVFMTAGYSESLFAALTFGGLYLLEKGFIFRACLALSIAAAARSNGLVNIGFLLYLPSLHAISQIRLYRATTKGHSKVFHYIWVIICLLLTSVLGTAIIALPFCAFQYYGYRTFCTPSTSLESIPPALLSIAERKGYRVPDENGPPPLWCMRPLPLLYSHIQDVYWDVGFLRYFELKQIPNFLLALPMATLGIIACYAYFQANPELCVRLGLWDTSANKGLDKPTPGFFNPRVFVYVVHSAVLLVFGTLCMHVQVLTRFMASSSPVPFWISAHLLLLNEPLLHRRKTSNPNVQLHSRNSCKHTPQNPIVALLPHLKACSSTTQSILGYFLSYWLLGLALHCNFLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVS8</accession>
    <name>A0A3P9CVS8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anillin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Bleb</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVS8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026092"/>
    <dbReference type="Ensembl" id="ENSMZET00005026933.1">
        <property type="protein sequence ID" value="ENSMZEP00005026092.1"/>
        <property type="gene ID" value="ENSMZEG00005016904.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008749"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032059">
        <property type="term" value="C:bleb"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01263">
        <property type="entry name" value="PH_anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000111">
        <property type="entry name" value="anillin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031970">
        <property type="entry name" value="Anillin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037840">
        <property type="entry name" value="PH_Anillin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF27">
        <property type="entry name" value="ANILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16018">
        <property type="entry name" value="Anillin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="744"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="884" mass="97655" checksum="FC1841A9D097C646" modified="2019-02-13" version="1">MDPFTEENLQKKLAERTNAANRQVVKRPREPLTDTNIVISESLIDKVPQTSTKPSPSKRKCSGENVQPAADEENQEPVMPQAPLLSDPPTDKKPPVGPARKPVLQSQAVQLKAERPEPDKVAVCTALVPPSRTEAQIGAANPAPQSNTEDPAPSAAGMKSRLKNLAEQRKCWNTDDCIPVSTIKRPFDAQPAASPSVSSEISLGRRGRLANLAATIGSWEDDLSHAKTPKRKQRRRSLLRLVPDLQSEVLRLPALNPAFRSPARVGVQTSAASVSPNTRSVQERLRAAQATNTTTADITMRQKLVAGRQLSSPPVLTSSPLKVAVHTTDKLTEETPEEKREENVDQSVNSTVINELFGDLEQSEDPSGDEEDALNISSMSSSLHWQRLCRCGKQSRKRMMTSTPANSFIMKSTTPDDVAIAKSFQTSSDGDGASVSSEDHKLPYSIDAYRSTRVKNTERPSVKQVIVRKEDVSKRAEEPRASSLFSVKQKIKILTNEINLQQTVIYQASQALNCCTDEEHGKGSQVEAEAERLLLVASEKREALKVELDQLKGNPGGRKEGPAAPQPMASKGCITLQELRLPLKADFVCSTANKPESTKHSFFIMIRAGAENIVATPLATTHRGLSGDTLTFPTKFTIAVPFQVQKREICSDKKKKTNKSKVIPVLFYVCCLLIMYVVAVVASPGGPNAVRTSNFALIGAYKLTLASIGKTHPCISVSIHTVVPFLCPLEGHIYLKMHCEVGSKVEERGFLTMFEDVSGFGAWHRRWCVLSGYCISYWTYPDDEKRKNPIGRINLSNCTSKAVEPASREFCARPNTFELITIRPRRDDDRETLVSQCQNTTCVTRNWLSADTKEERNLWMKKLNQILVDLRMWQPDACNRPLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CX40</accession>
    <name>A0A3P9CX40_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555769.1">
        <property type="nucleotide sequence ID" value="XM_004555712.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CX40"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026945"/>
    <dbReference type="Ensembl" id="ENSMZET00005027810.1">
        <property type="protein sequence ID" value="ENSMZEP00005026945.1"/>
        <property type="gene ID" value="ENSMZEG00005020099.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101480891"/>
    <dbReference type="GeneTree" id="ENSGT00530000063156"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="251" mass="28768" checksum="7F7184A28F786348" modified="2019-02-13" version="1">MADSEAGAAAAAAGMAHSFTQEYFQIPVVTRAYTTACVLTTAAVQLEFISPFQLYFNPELIIRRYQIWRLITSFLFFGSLGFSFVFNIIFLYRYCRMLEEGCFRGRTADFVFMFLFGGIVITLFGLFANIFFLGQAFIIMLVYVWSRRHPLIRMNFFGLLNFQAPFLPWVLMGFSLLLGNSIVVDLLGISVGHMYYFLEDVFPNQPGGRKLLMTPELLRAMFDRPEDPDYRPLLEEQQQGGALQPNGEQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CXG6</accession>
    <name>A0A3P9CXG6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 16 member 12</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>creatine(in) = creatine(out)</text>
            <dbReference type="Rhea" id="RHEA:73043"/>
            <dbReference type="ChEBI" id="CHEBI:57947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanidinoacetate(in) = guanidinoacetate(out)</text>
            <dbReference type="Rhea" id="RHEA:73047"/>
            <dbReference type="ChEBI" id="CHEBI:57742"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CXG6"/>
    <dbReference type="Ensembl" id="ENSMZET00005027637.1">
        <property type="protein sequence ID" value="ENSMZEP00005026779.1"/>
        <property type="gene ID" value="ENSMZEG00005019969.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156169"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015881">
        <property type="term" value="P:creatine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000128">
        <property type="entry name" value="monocarboxylate transporter 12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF318">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="16"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="472" mass="51323" checksum="44F45C4558BCC19E" modified="2019-02-13" version="1">SVSEPKGLHFTPEGGWGWMIVAGCFLATICTRAVTRCVSMFFVEFQMHFEKDYSNTAWIHSLIDSTTMLCAPLGSFLGNRLSCRATVILGGMLSSAGLIISSFANSLEYLYMSLGVLTGLGFALSYTPAIAMVGKYFSERKALAYGIALSGSGIGTFLLAPAVQLLIEYYSWRGALLILGAFVSNLCVCGALMRPLEPRGKDSKFNEAKQSDNNPLVNPSSRAQCFCFESREEFGFLLIPSFLILSMSFLFMAYGCSPPIVYLVPYALSLGVQPQHAALLMSVFGVCGIVGNITFGWITDRGRFRMLSYTVAMAMEGLCCMFMPFLSSFSLLVPFSILYGYFDGAYVALIPVVTSDTVGSTYLTSALGVVYFLHAIPYLLSPPIGGWLVDRTGNYAATFFLSGASFIFSSAVLAAAMLVRHCQRSKLNSAAHLNPTIFTKVEVKFNVSTNCKNGDNLNRFKFGPLCVINNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYR5</accession>
    <name>A0A3P9CYR5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CYR5"/>
    <dbReference type="Ensembl" id="ENSMZET00005028368.1">
        <property type="protein sequence ID" value="ENSMZEP00005027495.1"/>
        <property type="gene ID" value="ENSMZEG00005020502.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235219"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050488">
        <property type="entry name" value="Ig_Fc_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11481:SF64">
        <property type="entry name" value="FC RECEPTOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11481">
        <property type="entry name" value="IMMUNOGLOBULIN FC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017922137" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="31"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="105"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="196"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="318" mass="35899" checksum="6045014C0D250D55" modified="2019-02-13" version="1">CYQTPLKVRLLTKQLLGILHLMFCCVHSWSQIFTGETITLRCEIQGGEGKVWKYEWTAPNTNSPPTSSEYRISRVSVSHSGDYRCRGSSDYLLTGWSDIITLTVPVVTLYPNWSEIYRGETITVRCEIHGGDTEWHYEWETNSRIKAPNQSEYRIRSASSSNSGNYRCKGRMKSSQHETTEWSDSVTLTVSDSNKPRATLTAQSSVIPAGGSVTLSCSVEGSAGWKFDWFRRDSVSFKAQLMRGNEANRVSQGGLYHCRGGRGDPVYYTEDSSDVTVTETREFNYFIAAKLRDVILCSVLTISFNNYELIKPEMSDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D0B3</accession>
    <name>A0A3P9D0B3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myelin regulatory factor like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D0B3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028085"/>
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        <property type="protein sequence ID" value="ENSMZEP00005028085.1"/>
        <property type="gene ID" value="ENSMZEG00005020952.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MRF-like"/>
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        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
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        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF17">
        <property type="entry name" value="MYELIN REGULATORY FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
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        <property type="entry name" value="Peptidase_S74"/>
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    </dbReference>
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        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="9">
        <location>
            <begin position="78"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="10">
        <location>
            <begin position="383"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="6">
        <location>
            <begin position="78"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="678" mass="75244" checksum="BB1BE16589538432" modified="2019-02-13" version="1">MDPEASRLPAQVLGENEALQQFFNGQDVSGVLDSSVAVDTSILEQYLKSPSKTHRHFEIMFFICCSFGACKKEIAVDLRLSPVALHWSFESVFSCFSTLERKKRRRSESEEPSAGVGTSSSDGEGTHGGVGSTASVGGMGVGSYQLLSWEQYRPEQWSTLHDSNYQTLSPPAYHVDTDKGFNYSTADESFVCQKKNHFQVTVHIGVDAEPQYIKTASGPQEIDFFQIKVFGVKLETPSHLVTIEQSQPDRSKKPFHPVRVSLPGGKITRVTLGRLHFSETTANNMRKKGKPNPDQRYFQMVVGLYAVVKDESFPLTALVSEKIIVRASNPGQFETDGDTMWQRGVVQEDLVCQGRVGINTDSPDEALVVCGNAKVMGTIMQPSDCRVKENIQQVDSEQQLKRINQMKIVEFDYKPEFASKMGIDHTHQTGIIAQEVKELLPSAVKDVGDVICSDGEKINNFLMVDKEQIFMENVGAVQQLSKLTDNLETRINELEVWNRRLAKLKSLTGSLRSTGMSTISIPDACKTEKVQREEKSHKYSRCLRHKVFQISVFALLATMAFCVISITTLYLVNVKEEDFGTIPGNSNTTETPLQTSSWTSTVLPTGSPGLWPPAVDFCDLLYCDKVYCCPSSTEGTTNSNINISKSTEIPVMKGKVISLSIPVSEFVPVNMKVTLLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D210</accession>
    <name>A0A3P9D210_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Negative elongation factor complex member A</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004574169.5"/>
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    <dbReference type="Ensembl" id="ENSMZET00005029042.1">
        <property type="protein sequence ID" value="ENSMZEP00005028146.1"/>
        <property type="gene ID" value="ENSMZEG00005021004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484778"/>
    <dbReference type="KEGG" id="mze:101484778"/>
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    <dbReference type="GeneTree" id="ENSGT00390000005342"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030852">
        <property type="term" value="P:regulation of granulocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="HDAG_dom"/>
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        <property type="entry name" value="NELF-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056557">
        <property type="entry name" value="NELF-A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328:SF4">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A NELF-A"/>
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    </dbReference>
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        <property type="entry name" value="NELF-A_N"/>
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    </dbReference>
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        <property type="entry name" value="HDAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="89"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="320"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51838"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="547" mass="58865" checksum="AA80F4E62DE995DB" modified="2019-02-13" version="1">MASMKDSDTGLWLHNKLGSTDELWTPPSIASLLTVSVIDNIRLCFSSLSPPVKLKLLLGMLHLPRRTVDEMKEALSEIIQLATVDSEPWVLMVADILKSFPETGSLNLDLEEQNPNVQDILGELREKVSECEASAMLPLECQYLNKSALTTLVGPLTPPVKHFQLKRKPKSATLRAELLQKSTETAQQLKKTAGVPFHAKGRGLVKKIDTTTPLKGIPKAPFRSPTTPSMFSPPSNRTPIAPARTPLRKERGVKLLDISELDMVGAGREAKRRRKTLETEAGEKAAKEEAVVENTTPDYAAGLVSAQKLGSLNENPLPSTSYLPATPSMVPSSSYIPSSEAQPANAGGSGRDTLQAARQPEESATATTGANATLPGQYKQRPPMYNAGTTANPATPTSPSTPVSTPASNGPPAAATASQPETPTQPPSTPQTPTPTAAPTPPQPQPKKNLSLTRDQMYAAQEMFKTANKVTRPEKALILGFMAGSRENPCPEQGDIIQIKLSEHTEVLPKADGTGSTTMLVDTVFEMNYSTGQWTRLKKYKPITNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D275</accession>
    <name>A0A3P9D275_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras association (RalGDS/AF-6) and pleckstrin homology domains 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MRL family.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2L7</accession>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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        <scope>IDENTIFICATION</scope>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="227"/>
            <end position="416"/>
        </location>
    </feature>
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        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="425" mass="48873" checksum="00636C67BAABDEAB" modified="2019-02-13" version="1">MASTICLLPEKHFLCFLCRDIFTSPVTIPCGHSFCLSCLSKYWTRHQLKYCPHCRRLFTDKPDLSVNHILADISENYRKSRPQKPPDEETLLFYVNQMIQERVQKIERLKYSLGLQKNSYLREVRESQKIFSALVNAMEKSHKAVVAAIEERQREEESKVETLVKEIEQEIEELRKETKEPDPQISGDQSDDLKRPMKDWSKVTIETDPCIGVTRRALSDVLEQIKLEVNRLSKAELKRIEKYSVDVNLSAKTANPFLWVSDDRKQVRHTDKLQEVPENPKRFDRVGNVLAKESFAGGRCYWEVEVGEKIEWALGVARQSVNRKGKFTVCPANGFWTLSLKAGGQYIANTSPVTQLALDQRPKKFGVFLDYNEGRVSFYCADSGVHIQTFTDKFTDRLHPFFSPGRMHGGRNAAPLVICSSFCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D443</accession>
    <name>A0A3P9D443_9CICH</name>
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        <submittedName>
            <fullName evidence="1">Si:ch211-218d20.15</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
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            <authorList>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSMZEG00005021535.1"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="229" mass="26234" checksum="8A4BECA7683E157C" modified="2019-02-13" version="1">ISEPLCQPCGYHEAFKVELQVKRPLMPVQLSPEQVGLEMLCLCGQLDLLIRAQMQQSEILDQMLQCLEHLPKPMPQLEDYLDMVGLSAMFPRVEVFLIQGSPVDMLERPPMDYFHIAKLNQLLVLSQQLEEDIRHLGSHKYIAHQLSVIYQVLSSFRGIQVFSEIKKDIEANFKQMKQSLVVEEGSRHEPQLAVHYINILEITQSLTSMVLLLPDELTDDVHQAVTFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D547</accession>
    <name>A0A3P9D547_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the peptidase S1 family.</text>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1"/>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
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        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
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        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF94">
        <property type="entry name" value="AT20289P-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="28"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="236" mass="26357" checksum="148796769A6B1316" modified="2019-02-13" version="1">IHGLTRLSKLFSFSGITVSTGVDLHKRIYGGQKCPDTERQYHVKLKATSATHESLCGGSLIHERWILTAAHCWKNEPGWDMYATLGVHPSPWWTKLLPFLKKQKKVEITGGSFFVGINTIDDIMLLEIPSQPEPGESPSLHCAETEVVSCTELNDILLKKFPEVHRVRSYQHWFCGQSPGKDICRGDSGGGVVHNGRIYGVSSFVGDLDFVCRAPAAFMDLCDPEYADWIRKTINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6M9</accession>
    <name>A0A3P9D6M9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-phase cyclin A-associated protein in the ER</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004553217.2">
        <property type="nucleotide sequence ID" value="XM_004553160.3"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005029999"/>
    <dbReference type="Ensembl" id="ENSMZET00005030943.1">
        <property type="protein sequence ID" value="ENSMZEP00005029999.1"/>
        <property type="gene ID" value="ENSMZEG00005022370.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101486416"/>
    <dbReference type="CTD" id="49855"/>
    <dbReference type="GeneTree" id="ENSGT00390000011159"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000680">
        <property type="entry name" value="S phase cyclin A-associated protein in the endoplasmic reticulum"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032446">
        <property type="entry name" value="SCAPER_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16501">
        <property type="entry name" value="SCAPER_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="883"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="944"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1484" mass="165822" checksum="54713ED609A64897" modified="2019-02-13" version="1">MSKDNRYDGRRRGAGQHRLGPRVSNQGGDGRERSGSNSSGSSHGGGKSKNASITALKASFQRSNSHDKVRKIVAEEGRAARNLIAWSVPLESKEEEAKSKGNSSGSSRSQRINSGQQRNKKQNAAVENKGTAGALLEKGPEKSPTKVRQPRKVDLRARYWAFLFDNLRRAVDEIYVTCESDQSVLECKEVLMMLDNYVRDFKALIDWINLQEKLEKTDAQNRPTSLAWEVRKMSPGRHVMPSPTDRMVPTPGARRALNFGGPPATRHSHTGPSWADRVKCTQSVLGSCQPTTSQAEKPGKKDAEGWETVQRGRTAKPRSAAMVAKVSPVLACVTPKQDNNKGNQSRAPPQANEQLRPECPHHKDVSQTDTKQQIPSEPEPQEEVEGPENGQIMEPPAESPQGSGQCVDAPCEDVPPTIAALTPFQPPEHTPSITSPTDITLSVPVSVVTLATSLDLPQTDGLSTQLAFGDSGAEGGTSQGMATSAAGQAETPMAAVKLESVLDPTELSTPQSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIQAENNDLETDNESDFSASIGNGSCGANIDWNDMLADYDAREPWRQTTSWGDMVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQLKAQQLRDKLREEKTLKLQKLLEREKDVRKWKEELLEQRRRMMEEKLLHAEFKRELQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDALAKLSEYEQRLNELQEERQRRQEEKQARDEAVQERKRVLEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALSAAQQEAMEELQKKIQMKHDESSRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCGVVITSEVHLFSHTKGKRHQQAVRDSSSIQGRELSDEEVEHLSLKKYIVDILTDSSVSSESVKDGEERQKARKKAKKLRARMNSRAKEYETSMEAKTQVPDSPYKAKLQRLVKDLLKQLQGQDSGQWANNKVSGLDRTLGEISRILEKQNNADQVAFQVGGGLSALEQILQVITAASTPTAVPRIPLKSLCSAVNIYNLACSCCALNCSYVLFSNKIVLLMDLLLHQLTLYVPDEDKSIFGRSVNKQVFEGLTTGLLQTISTILGSLWPHISDSGQGENTCISSQDAKVKSSAAESFNTRTQDLISYVVNMGLIDKLYGCFLSVQGPVDEQPKMSAFLQQASALLHSMCKLCFVVTGRAPSIFDNKRQDPTGLTALLQSTDLVGVVHTLYCILLHSFLPESACQSQEPYGPGVIQVALQGIRFLNSFALLDLSAFQSVLGAEGLSLAFRHIVSSLLWYCTQQSSEELLHEVIICVGYFTVNHPDNQVIVQSGRQPSVLQKLCQLPFQYFSHPRLIKVLFPSLISACYNNPENKVILQQEMSCVLLARFIQDCASEEKDSDNKPSKTVFQPLDFCELSNRFPRDQWDSALQFFLKKQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D750</accession>
    <name>A0A3P9D750_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain 10b</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004551408.1">
        <property type="nucleotide sequence ID" value="XM_004551351.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D750"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030002"/>
    <dbReference type="Ensembl" id="ENSMZET00005030947.1">
        <property type="protein sequence ID" value="ENSMZEP00005030002.1"/>
        <property type="gene ID" value="ENSMZEG00005022374.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480680"/>
    <dbReference type="KEGG" id="mze:101480680"/>
    <dbReference type="CTD" id="559527"/>
    <dbReference type="GeneTree" id="ENSGT00940000156564"/>
    <dbReference type="OrthoDB" id="5402602at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF17">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 10-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="337" mass="36328" checksum="4E651F8B4289685F" modified="2019-02-13" version="1">MSVGVESGFSSEEVLNSRFPLHRACRDGDVGALCSLLQCTSNPADLTVEDTFYGWTPIHWAAHFGKLDCVMRLVQVGCGVNAVTSRFAQTPTHIAAFGGHPECLLWLLQAGADINKQDYVGETPIHKAARAGSLECINTLLIQGAKADMRNASGLTAADLAHAQGFRECAEILSNAQNFQQNMAQSHNGVFLNGMSQNGCHTYPTIQGRSFLNGMPNRKRSFEGMEANPGKKARTNGFCVEPKLLNGNGPLDGAGDAQMESMNMELAATVTSVAGERHCEDFFSNGPTAEILDHHIHSGSPEIISTGGSQVEHLKSVKAEQFYDHTLFSTMLLYHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D763</accession>
    <name>A0A3P9D763_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D763"/>
    <dbReference type="Ensembl" id="ENSMZET00005031359.1">
        <property type="protein sequence ID" value="ENSMZEP00005030403.1"/>
        <property type="gene ID" value="ENSMZEG00005022649.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286952"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001639">
        <property type="entry name" value="Si:dkey-7i4.21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="349"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="380" mass="43775" checksum="79EFA81C2832562B" modified="2019-02-13" version="1">EEEEEEEEEVLPEQQLWNQERSSSVEQEEPEAPQIKEEQEELCSSQQGEAFKKKCQVKEHRKIHTGEKPHSCKICQRSFTQKSTMLRHMIIHTKEKSYSCLTCGKTFSQSGNLYVHMRIHTGEKPYSCKTCGKTFKNSYVKEHQKIHSGEKPYTCQTCEKSFTRRAHLLGHMRTHTGEKPYSCETCGKGFTQSSHLLSHMRLHTGEKPYACEICGKGFIQRGHLLVHVRTHTDEKPHTCEECGKSFRFSGTLSVHMRTHTGEKPYSCKACGKSFRQKKILSVHMRTHTGEKPYSCTTCGKGFAQKSDLTIHERTHTGEKPYPCKACGKSFRQKNILSVHMRTHTGEKPYSCKSCGKSFRQKSILSVHMKTTIKFLHYNMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7P2</accession>
    <name>A0A3P9D7P2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adipolin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Adipose-derived insulin-sensitizing factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Complement C1q tumor necrosis factor-related protein 12</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adipolin/erythroferrone family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004572440.1">
        <property type="nucleotide sequence ID" value="XM_004572383.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7P2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030364"/>
    <dbReference type="Ensembl" id="ENSMZET00005031317.1">
        <property type="protein sequence ID" value="ENSMZEP00005030364.1"/>
        <property type="gene ID" value="ENSMZEG00005022626.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466520"/>
    <dbReference type="KEGG" id="mze:101466520"/>
    <dbReference type="GeneTree" id="ENSGT00940000160300"/>
    <dbReference type="OrthoDB" id="6360045at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000012">
        <property type="entry name" value="Adipolin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052136">
        <property type="entry name" value="Adipolin/Erythroferrone-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019">
        <property type="entry name" value="ADIPOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24019:SF13">
        <property type="entry name" value="ERYTHROFERRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018120997" description="Adipolin" evidence="12">
        <location>
            <begin position="37"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="13">
        <location>
            <begin position="152"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="305" mass="32905" checksum="C2800F3F83EC7300" modified="2019-02-13" version="1">MLARLSQRKSAPGGSRGLLLLPLLLTMMMMVTMVKAASVDEVESEEGQEIMEDEEAVSGELQDLTSSESGRVSPHSSWLFFRRNSNRGDNRRSKGPRRTSKHGLPGPPGPPGPQGPPGPPAALLPQQQELIQELKVKLKDMAAAVRLPCDRPPRISTSFFSRLLQSITIPRRSLLELQPFSKPSDSEQSLQRGRSFNSSTGRYTAPVSGFYQLTASLLIESGDRVQVRLRDSVKAAICIESLCQSNLSVESVMGVAAAGGTFSMLLTGTLYLQAGEYVSVFVDNATGSAISILQDSLFSGILLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7S7</accession>
    <name>A0A3P9D7S7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle membrane</location>
            <topology evidence="13">Lipid-anchor</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004553187.1">
        <property type="nucleotide sequence ID" value="XM_004553130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7S7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030151"/>
    <dbReference type="Ensembl" id="ENSMZET00005031100.1">
        <property type="protein sequence ID" value="ENSMZEP00005030151.1"/>
        <property type="gene ID" value="ENSMZEG00005022476.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478685"/>
    <dbReference type="KEGG" id="mze:101478685"/>
    <dbReference type="GeneTree" id="ENSGT00940000155363"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="207" mass="23568" checksum="69865C7921B45D45" modified="2019-02-13" version="1">MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDSFNTTFISTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDICNEKSFENIKNWIRNIEEHASSDVEKMILGNKCDMTDRRQVSKDRGEKLAIDYGVKFLETSAKSGLNVEEAFYTMGRDILHNLSSKSTDNSAGGSGKPVKITEKKSKRIKFFKCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7Z4</accession>
    <name>A0A3P9D7Z4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Breast cancer anti-estrogen resistance protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CRK-associated substrate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">p130cas</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004556306.1">
        <property type="nucleotide sequence ID" value="XM_004556249.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7Z4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030484"/>
    <dbReference type="Ensembl" id="ENSMZET00005031445.1">
        <property type="protein sequence ID" value="ENSMZEP00005030484.1"/>
        <property type="gene ID" value="ENSMZEG00005022717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473839"/>
    <dbReference type="CTD" id="9564"/>
    <dbReference type="GeneTree" id="ENSGT00950000183008"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901490">
        <property type="term" value="P:regulation of lymphangiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903670">
        <property type="term" value="P:regulation of sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11552">
        <property type="entry name" value="Serine_rich_BCAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12001">
        <property type="entry name" value="SH3_BCAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.830:FF:000001">
        <property type="entry name" value="BCAR1 scaffold protein, Cas family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000001">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000009">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.830">
        <property type="entry name" value="Serine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035745">
        <property type="entry name" value="BCAR1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021901">
        <property type="entry name" value="CAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037362">
        <property type="entry name" value="CAS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014928">
        <property type="entry name" value="Serine_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038319">
        <property type="entry name" value="Serine_rich_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654:SF15">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654">
        <property type="entry name" value="CAS SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12026">
        <property type="entry name" value="CAS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08824">
        <property type="entry name" value="Serine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="129"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="667"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007848"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072413"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="949" mass="104159" checksum="CD480A0934E8B6FA" modified="2019-02-13" version="1">MSVPNILAKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDSKQQQAIPSTPDPAVSCPTSQVQRPLHPPSAYPKPTPPLSSIASMSSSGFANKTLPSTQYTSMHSAYSTPSPAQPNPDSVYMMPPSHSPKPSLQSVYQVPSGPSGTSTQAQPGPPSKASAQGQRQPGKEIYQVPPSVGPAPGQATAPAGQDVYQVPPSLDRRNWDSSNKPLGKVVVPTRVGQVYVYDAVKPDQDEYDVPPRLQPPAQPDIYDVPPTRQQYSTQVYDTPPMVMKGPSGGQDIYDTPASSEKNPQQMVYDFPPSVSKDVSDVQPIREETYDVPPHFAKLKPQVPITPGPYLHNNLSSNDDEPPIPEDVYDVPPPILTDKHYHRDRSGASQAPQQIYDIPAVLRVGQDVYDFPREREETGERAEQNVYDVPPQVVRDAQSASEELSMSFKRLSASSTGSTRSNHSASSLDMVPVRDTTSLPAPGSIPGKPLVLEMDQAMERLSRLQQAVESSVSFMMSFITGNWRSPAHLEGNLPAIHQAADRVRTTVRDFLEFARGAVANAAQATDRSLQAKLGRQVGKMEEIFQNLIRHSQSLDAISWSHAALTAPPPGGDDLDRLIMTARGIPDDAKQLASFLHGNASLLFKKTTRQQQMPLPPIPGELSGHTTGSGSGSYQGGEKVNIQSRPLPSPPKFTAAEEEEGVERPYETTEEGWMEDYDYVHLQGKEEFEKNQRQLLEKGNIIRNNKTQLEQQQIKQFERLEQEVSRPINNDMTGWVPSVHNSLANYLAQNGSGGPASSKLCHGDRQLILFYQEQCEQNVTTVTNAIDAFFTAVNSNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKSPEVRARVAQSSNSLCEKLKDIVISTKTAALQYPSPGASREMTEKVRELAGCTQHLRMVLGQLLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAS2</accession>
    <name>A0A3P9DAS2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/calmodulin-dependent protein kinase IGb</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAS2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031459"/>
    <dbReference type="Ensembl" id="ENSMZET00005032480.1">
        <property type="protein sequence ID" value="ENSMZEP00005031459.1"/>
        <property type="gene ID" value="ENSMZEG00005023450.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156872"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045475">
        <property type="term" value="P:locomotor rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000453">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="426" mass="48646" checksum="9EBB9D1EC58D0FDF" modified="2019-02-13" version="1">MGRQEADYVWKKNTENIQEVFDFMEELGSSGAFSEVYMVKEKKTGKNFAMKCVKKKQKRDLNLENEIAVLRRIKHENVVGLEDFYESRTHYYLVMQLVSGGELFDRILDRGVYSEKDASRVIQQVLEAVSYLHQNGIVHRDLKPENILYYSQEENSKIMISDFGLSKMVDNGIMSTACGTPGYVGKKTCHSRGIISHSLCGYPPFYEESESRLFSKIMKAQYEFDSPFWDDISESAKDFIRNMMQKNPKMRYTTDLALRHPWIIGKTARSQDIYYSVSVQIQKNFAKSKWKQAYNAAVAINHMKKLQLAHSEQVLRQASIPDIRVIDVSSPTKNRKHLDPDKVEPKVPEVNGSVQGTHHMSLLTSHVELKSHCHPLKTSQSHCSAQHAPTIAEQGKHVYHSEPANLNGYGKKNNNSKTITGVCAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAV7</accession>
    <name>A0A3P9DAV7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Double C2-like domains, gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="131"/>
            <end position="253"/>
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        <location>
            <begin position="279"/>
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            <begin position="1"/>
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        </source>
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        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="426" mass="47309" checksum="FAA045B4A5901AD1" modified="2019-02-13" version="1">MSVSKPPPPPSTSHLAIPPSSASTPSSSASSPSATPHSIAPPPPSPVKISMQEHFAINVCPGPILPIPQISDFFPRFHDYPCTPPPPREKKILKEETFNGETGGGYKDGERRGENEGDREELIDSDDDDTYLGTLEFNLLFDQENNCLHCTIHKAKGLKAMDSNGLADPYVKLHLLPGASKANKLRTKTLKNTLNPVWNETLVYHGITAADMTTKTLRLCVCDMDRLGRNEFIGEVRVALKKLKEGESKRYNMGLERIAQNKETNNQTQEQGALVAEEERGRILVSLCYNTEKGCLLVGIIRCAHLAAMDSNGYSDPFVKTVLQPDMGKKSKYKTSVKKKTLNPEFNEEFSYEVSLDQLAKKTLEITVWDYDLGMSNDFIGGVELGINASGERLRHWFECLKNKGKKVEYWHTLTQQGAPSSDKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3P9DE38_9CICH</name>
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        <alternativeName>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with TAX1BP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="ENSMZEG00005024553.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of Rho protein signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_DLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_DLC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000007">
        <property type="entry name" value="rho GTPase-activating protein 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000009">
        <property type="entry name" value="StAR related lipid transfer domain containing 13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="StAR-related lipid transfer domain-containing 13"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
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    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
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    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
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    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
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    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659">
        <property type="entry name" value="RHO-TYPE GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659:SF8">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 13 ISOFORM X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM_2"/>
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    <dbReference type="Pfam" id="PF01852">
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    </dbReference>
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        <property type="entry name" value="Bet v1-like"/>
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        <property type="entry name" value="GTPase activation domain, GAP"/>
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    <dbReference type="SUPFAM" id="SSF47769">
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="15">
        <location>
            <begin position="947"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="16">
        <location>
            <begin position="1194"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="148"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="197"/>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="463"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="706"/>
            <end position="762"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="816"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004346"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022677"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00065039"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076865"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032955.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1408" mass="158050" checksum="6A736C9A92D8F4BA" modified="2019-02-13" version="1">MSESVPLLLCALDPVTSHTTKWNKLKMDKSSLHDAPVSDFRQNGHCECRQSSDMSPGAGQDMEVSSLDRRAAVHSDSQMEAENVKDCGAKIPQQKDESPAETPTVLDKCCHKRLPASMNTPEDVLRVVKHHPSAIVFCDYDCGTGNQVINESSDGGESSSSTSKEAEGEDGDDDDFPATLQYKEFLVSRRRRNLSRNRKCLRRRQDAQPNSTPFDWQKLNKGKPGFTGSQEEEDTWEKNGKQASAYDSMTLLMKKLDHLNEGIQEVQGAISSYSNEASADEEQQSTTGSVAVDRMVSRVNQDQGTSRFPDKSEPLSRRCSRPLTRSRPLTRSSLSSPIHLQARRARATGKMTSDSAEIEAKEACDWLRAAGFPQYAQLYEDSQFPLDISSVKRDHDFLDRDLVEPLCRRLNTLNKCASMKLDVSQPKKKGDDSDEDDPLAISKRWTFEWSSRRWSRLQDFLSDSTNESSPTGQGEGLHSTVSSESVLTDLSEQEITEISSLHSEDSASAMPDSISMASLSASYQPPRELPHYNSLPIKSSRHGQGRRNKAKEFLRRMEIMRTWGPSTRRKGSNRRPPLVISGPVLQGEEPQALQMLQCTPISQLEQSPKHNHQTDGDISPDSLSKDCKDQVTVSVSPSNETVELPVKEPVCIKPRTASKRSSMYLEDMVLPSQGKRTEGQSQFGRHQFHSYENLLIHIPKDHKPGTFPKALSIESLAPSPGDRNNDSHVHARTSPRDNGLGEPWSGKPLSKPCPGAPRGSRVSVYDNVPGSHLYASTGDLLDLEKEDNLFPHLDDIIQHVSGLQQIVNHWSRSVLPEGETGEGEEEGEGRTTPSEGERDGVSLNDTDSTGTSRERRDSGVGASLTRPRLRWPSFRTSDHLNQPASSLQISSQSAGQLSLLQKFSLLRLTAIMEKYSMSNKHGWTWSVPKFMKRMKVPDYKEKSVFGVPLIVHVQRCGFPLPLCLQQALSHLRTHCLDQVGLFRKSGVKSRIQALRQQCELSPDCVNYEDQSAYDVADMVKQFFRDLPEPLLTSKLGETFLHIYQYVPKEQRLQAVRAAILLMPDENREVLQTLLYFLRDVTSMVEENQMTPMNLAVCLGPSLFHLSILKSEALSPRSIQRKYTTGQPDQKDLSENLAATQGLAHMITECQRLFQIPEEMVTQSHNSYMEAELMVPPLDELCKAHEEEVDVDEEEEDEEGSYHAHLERLIQNLLKEAKDKSKGWVSRSTTDHTELSFKKVGDGNPLRRWRVCVEVSAAPAAVLHRLLRERPLWETELQQEKILETLDKQTDVYLYSCCNMPPQPTCEYVVLRSWRTDLCKGSSALVSVSVDHEDSPPIGSVRGVVLESQYLLEPCGTGRTRLTHICRVDLRGRSPEWYNKAFGHLCVNEAQRIRSSFLPVDQTSPEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEU8</accession>
    <name>A0A3P9DEU8_9CICH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized LOC105940994</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="134" mass="15148" checksum="A7CE762766F3765F" modified="2019-02-13" version="1">MGCYHDSAKYERVYIKRESRCPLSHWEKPRQTYSKAAMLNRTMKLLVLALAVALLFTAGEALDCHRCVPKRAGGSCELTVETCKPEKNGCASANFLKAPYGHYQKCMDLDSCEMLKMNAYINMKCCSEDMCNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGA3</accession>
    <name>A0A3P9DGA3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-C motif chemokine 3</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intercrine beta (chemokine CC) family.</text>
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        <property type="gene ID" value="ENSMZEG00005025229.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF108">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018229851" evidence="3">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="4">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="91" mass="10207" checksum="D7CE9E8FC5D9F47E" modified="2019-02-13" version="1">MKTTHILLLCILGAALLSAVNCTTGNGPDNCCFKFYPRRIRANLVESYYMTDHRCPKPAAIFITKKARSVCMDPSLSWVDSIMKTLDESTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGB9</accession>
    <name>A0A3P9DGB9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Acid-sensing ion channel 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Amiloride-sensitive cation channel 2, neuronal</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory. Upon extracellular pH drop this channel elicits transient, fast activating, and completely desensitizing inward currents. Displays high selectivity for sodium ions but can also permit the permeation of other cations. Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines. Modulates neuronal activity in the circuits underlying innate fear.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Li(+)(in) = Li(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78551"/>
            <dbReference type="ChEBI" id="CHEBI:49713"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_023010431.1">
        <property type="nucleotide sequence ID" value="XM_023154663.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGB9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033503"/>
    <dbReference type="Ensembl" id="ENSMZET00005034650.1">
        <property type="protein sequence ID" value="ENSMZEP00005033503.1"/>
        <property type="gene ID" value="ENSMZEG00005025031.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468841"/>
    <dbReference type="CTD" id="407670"/>
    <dbReference type="GeneTree" id="ENSGT00940000158414"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.470.10:FF:000001">
        <property type="entry name" value="Acid-sensing (proton-gated) ion channel family member 4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.820:FF:000001">
        <property type="entry name" value="acid-sensing ion channel 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3590.10:FF:000002">
        <property type="entry name" value="acid-sensing ion channel 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3590.10">
        <property type="entry name" value="acid-sensing ion channel 1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004724">
        <property type="entry name" value="ENaC_chordates"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00859">
        <property type="entry name" value="ENaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF170">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00044635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00060249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00069596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="523" mass="59123" checksum="3A6E158739D7E4D6" modified="2019-02-13" version="1">MKGSSEESIESVRPSNLQAFANMSTLHGMSHIFAYGHMTFRQFLWTLSFLGSLGLLMLVCMDRVSYYLEYPHVTKLDEVAATNLTFPAVTFCNLNEFRFSKITKNDLYHVGELLALLNNNYQIANPHLAEPEVLAALKDKANFLNFKPKLFNMTDFYNRTGHDISDMLLQCTFRGEDCHPGNFTTIYTRYGKCYTFNSGLDGNPLLTTLKGGTGNGLEIMLDIQQDEYLPVWGETDETSYEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQQQLLQYLPPPWGDCKSTPIDSDYFSTYSITACRIDCETRYLLENCNCRMVHMPGNTAVCTPEQYKDCADPALDFLVEKDNNYCVCQTPCNMTRYGKELSMVKIPSKASAKYLAKKFNKTEQYIGENILVLDIFFEALNYEKIEQKKAYEIAGLLGDIGGQMGLFIGASVLTILEIFDYLYEVFKDKLLGYFIRKKRPQRCQSDNLEFPENPTSPGVTPNHAPRAPVTPSGVTRTVSDSPRTCYLVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGF9</accession>
    <name>A0A3P9DGF9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox protein CDX-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Caudal homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGF9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033216"/>
    <dbReference type="Ensembl" id="ENSMZET00005034339.1">
        <property type="protein sequence ID" value="ENSMZEP00005033216.1"/>
        <property type="gene ID" value="ENSMZEG00005024790.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164078"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Lim Z.W."/>
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                <person name="Alcazar R."/>
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                <person name="Aken B."/>
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                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
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                <person name="Eshel O."/>
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                <person name="Galibert F."/>
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                <person name="Tan F.J."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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                <person name="Streelman J.T."/>
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            <text>ATP + H2O = ADP + phosphate + H(+)</text>
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</entry>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
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                <person name="Jaffe D.B."/>
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    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has glycerol-3-phosphate dehydrogenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:11093"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="13"/>
    <dbReference type="RefSeq" id="XP_004546281.2">
        <property type="nucleotide sequence ID" value="XM_004546224.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJH6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034910"/>
    <dbReference type="Ensembl" id="ENSMZET00005036154.1">
        <property type="protein sequence ID" value="ENSMZEP00005034910.1"/>
        <property type="gene ID" value="ENSMZEG00005026111.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484659"/>
    <dbReference type="KEGG" id="mze:101484659"/>
    <dbReference type="GeneTree" id="ENSGT00390000003114"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000088">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000084">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF32">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)], CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="15">
        <location>
            <begin position="198"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="351" mass="38022" checksum="813720FB88D3508C" modified="2019-02-13" version="1">MAAPKKVCIVGSGNWGSAIAKIVGANAGKNAKFDNTVKMWVFEETVNGRKLTEIINSEHENVKYLPGHKLPANVLAVPDLVEASSDADILVFVIPHQFVGKVCDTIKGKIKNDALGISLIKGVDEGPDGLKLISDVIQEKLDITMSVLMGANIANEVADEKFCETTIGCKNKNHGALLKELMQTSNFRVTVVEEYDVVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFARIFCKEGPVSSATFLESCGVADLITTCYGGRNRKVAEAFVRTGKSIEELEKEMLNGQKLQGPATAAEVYLILKHKNMVDKFPLFNAVYQICFEGHPVTEFISCLQNHPEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJZ4</accession>
    <name>A0A3P9DJZ4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJZ4"/>
    <dbReference type="Ensembl" id="ENSMZET00005035719.1">
        <property type="protein sequence ID" value="ENSMZEP00005034507.1"/>
        <property type="gene ID" value="ENSMZEG00005025782.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000245001"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16991" checksum="465F3C74F60082AA" modified="2019-02-13" version="1">MVSFASVDASDVQRMCGKNTKVLCFPKDMVNNLKERILQIADEYPTVTNIVLHTGSNDVSKQQSEVLKRDFTGLLNTVNSLNAAVFISGPVPPVRGGDERFSRLFTLNKWLISACTDHSVHGEAAFSFYAPYIWNKLPEASDQLKHSVYLNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK76</accession>
    <name>A0A3P9DK76_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cadherin 26, tandem duplicate 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004546248.1">
        <property type="nucleotide sequence ID" value="XM_004546191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DK76"/>
    <dbReference type="Ensembl" id="ENSMZET00005036011.1">
        <property type="protein sequence ID" value="ENSMZEP00005034773.1"/>
        <property type="gene ID" value="ENSMZEG00005025993.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474933"/>
    <dbReference type="KEGG" id="mze:101474933"/>
    <dbReference type="CTD" id="571792"/>
    <dbReference type="GeneTree" id="ENSGT00940000161589"/>
    <dbReference type="OrthoDB" id="9045962at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000095">
        <property type="entry name" value="Cadherin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000019">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000031">
        <property type="entry name" value="Cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000202">
        <property type="entry name" value="cadherin-8 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF78">
        <property type="entry name" value="CADHERIN-LIKE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018318619" evidence="16">
        <location>
            <begin position="20"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="37"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="142"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="272"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="371"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="485"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="812" mass="91397" checksum="08CCE2D47EA63488" modified="2019-02-13" version="1">MRISLFLLVAAAAVADCYGSKYSSPSKRDLLVRSKRRWVLSTIELEEEKDAQYPVEISVMYNDKTQGKDFRFRLSGEGVPDVFTINENTGVVFAHKKVDREQKPLYHINFDVLDRNTGEQLDKELAFDVEIQDINDNPPMFSFPEVTVNVKENIQGSLLPVTLVVTDKDKENTPNSEFNITMVSQTPAEPKIAVQQLPGGLAKLTLKGCFDYDKATKYTIVLQAKDRGTKPKTQSSTAVVTLNIVDANTHQPRFKQRQYNGEAIEMETIANVLRVAVEDKDTPNTDAWRAKYSIIAGNEEGIYKIETDPETNEGVLSIVKKKNFERTTSINLQIGVKNIEDIFVCAGTNPPTDRANVTLKMIDTNDPPEFEKTINDMHLKEEAEPGKVLFKPKVHDVDSNITRYVLLTDPADWVAIDTKTGEIKSTKRMDRESRFVDDENVYTVVIAAIDDGQPPATSTCTVRIHLTDINDNTPKLVNNSAVMCGNKVNKVKVRAKDLDAIPYSGPFHFTLGDETQKQQWKIEPDYGEEVSLVSQKTLPYLNYSIPLVIMDQQGIAGHDTLQLTVCQCDENDVCRDREPLSTRLGPAGIGLVIIGLLAFLLLLIAFFCKFGPDKILPQDEGNQTLIQYNQEGGCSPCTTEPNFVQSQVDNMAVTNGQMDTMQIDTEGPYDVNRYNSSVSTMFHSLGMDQQETYRSHGMRSMRMNSTWNSNRMNTYRAGSSIYQRSFSLRSADRIEDHINRRCNEVDGNVVDHPTYQPHSYAFEGDGSICQSLDKLSFHDMGEDFKYLDDLGPKFKTLGQMYDEAIKKKKVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DKI3</accession>
    <name>A0A3P9DKI3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DKI3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034671"/>
    <dbReference type="Ensembl" id="ENSMZET00005035905.1">
        <property type="protein sequence ID" value="ENSMZEP00005034671.1"/>
        <property type="gene ID" value="ENSMZEG00005025920.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014512"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="99" mass="10707" checksum="6007E02AFCAACED7" modified="2019-02-13" version="1">AEGGGKGGKGERSGRARHGSIRSPIWRGGGVSHGPRGPTSYYYMLPMKVRVQGLKVALSSKMAQDDLHIVNSLNIPTPDSQYLLDLIRHRGESVLIVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLB1</accession>
    <name>A0A3P9DLB1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein heavy chain hydrolytic ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLB1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034977"/>
    <dbReference type="Ensembl" id="ENSMZET00005036223.1">
        <property type="protein sequence ID" value="ENSMZEP00005034977.1"/>
        <property type="gene ID" value="ENSMZEG00005026171.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155533"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF13">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="13">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="197" mass="22022" checksum="626797FCBB2A0F8F" modified="2019-02-13" version="1">MFVCLQLDRCYITLAQALGMSMGGAPAGPAGTGKTETIKDMGRCLGKYVVVFNCSDQMDFRGLGRIFKGLAQSGSWGCFDEFNRIDLPVLSVAAQQIAIVLTCKKERRKNFVFTDGDNVDMNPEFGIFLTMNPGYAGRQELPENLKINFRSVAMMVPDRQIIIRVKLASCGFINNMELARKFFTLYKLCEEQLSKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMX0</accession>
    <name>A0A3P9DMX0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Keratin 18b</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMX0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036145"/>
    <dbReference type="Ensembl" id="ENSMZET00005037419.1">
        <property type="protein sequence ID" value="ENSMZEP00005036145.1"/>
        <property type="gene ID" value="ENSMZEG00005026974.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163961"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF375">
        <property type="entry name" value="KERATIN 18B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="88"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="300"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="429" mass="48025" checksum="C93891D18218B440" modified="2019-02-13" version="1">MTTRSSRMSFTRSTPVYRAASIYAGAGGQDVRISSASASSLRSGIPLRPSTSFKLSSGLSGGMGAGYGGASASVTASGGSGASILGNEKGAMQNLNDRLANYLETVRTLEKANKELELKIMEALEKGGPDIRDYSKYEPIIDDLRRQIFDKIMDNARLVLQIDNARLAADDFKVKSENEMAIRLSVEADIGGLKKVLDETNMSRLNIENEIEAVKEELLFLKKNHENVSLRFIRLIITYRVTRFVVFFISFLILLIQQEVMELRSQISQSGVQVDVDAPKGQDLSQIMEDMRANYEKIALKNAEDLKRWHENQIADVQVQVSQNTEALQGAQMEKSDLSRQIQTLEIELASQQSLKASLEDTLRNTELRNNIEMEKYNTLIIRLEEELASLRANIQQQTQEYEALLNMKMKLEGEISTYKTLLDGGDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPZ8</accession>
    <name>A0A3P9DPZ8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein Pegasus</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ikaros family zinc finger protein 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DPZ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036830"/>
    <dbReference type="Ensembl" id="ENSMZET00005038119.1">
        <property type="protein sequence ID" value="ENSMZEP00005036830.1"/>
        <property type="gene ID" value="ENSMZEG00005027448.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155035"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071908">
        <property type="term" value="P:determination of intestine left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003140">
        <property type="term" value="P:determination of left/right asymmetry in lateral mesoderm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035469">
        <property type="term" value="P:determination of pancreatic left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000402">
        <property type="entry name" value="IKAROS family zinc finger 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000924">
        <property type="entry name" value="IKAROS family zinc finger 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001097">
        <property type="entry name" value="IKAROS family zinc finger 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF55">
        <property type="entry name" value="ZINC FINGER PROTEIN PEGASUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="311"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="427" mass="47387" checksum="1008780679A96E93" modified="2019-02-13" version="1">MGEEKPDTLDFVKDFQEYLSQQTQHVNMISGSVSGVKEADELPQGSGTDCSQNGLDHPSVDMSLEDNSGILVDGFERTYDGKLKCRYCNYATRGTARLIEHIRIHTGEKPHRCHLCPFASAYERHLEAHMRSHTGEKPYKCELCSFRCSDRSNLSHHRRRRHKLLPMKGARSLSHKKMLSVLQKKASSLGYGRRLLINFSPPSMVVHKADNVNDFSHELPHLRQETYDNQSRAGEDALSANQNHHHHDMVVDNPLNQLSTLAGQLASLPSESQPQTQPSMSPGAESIIDEKPFLIQQPHPATAPVAVTANMAHASSSSPIPPEPRAPPHSNCSPGAGPCSEHSGRTSTPSISNSQPSTPAPGLSAPLQDPHMLHHCQHCDIYFPDNILYTIHMGCHGYENPFQCNICGHKCKSKYDFACHFARGQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ98</accession>
    <name>A0A3P9DQ98_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004558835.1">
        <property type="nucleotide sequence ID" value="XM_004558778.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ98"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036448"/>
    <dbReference type="Ensembl" id="ENSMZET00005037729.1">
        <property type="protein sequence ID" value="ENSMZEP00005036448.1"/>
        <property type="gene ID" value="ENSMZEG00005027204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464338"/>
    <dbReference type="KEGG" id="mze:101464338"/>
    <dbReference type="CTD" id="7480"/>
    <dbReference type="GeneTree" id="ENSGT00940000160653"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF76">
        <property type="entry name" value="PROTEIN WNT-10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="429" mass="47860" checksum="7D00D790AEBD9069" modified="2019-02-13" version="1">MELSNKLRWDQFLILAAALMSPAITVLCNDILSLKVAGDPVLTPNSVCLRLAGLSKRQMRMCVRNPDVTASALQGIQVAIHECQHQLRDQRWNCSSLEGFGKLPLHNSILNRGFRESAFSLALLAAGVAHSVASACSMGKLRGCGCEAKRRQDDDKIRLKLTQLQLQTLQKGGAGIDLTRSLPSELNGHRGSLPTNLRSAHPSALLKPLPDELSSMQDTWEWGGCSHDIRFGDRFSRDWLDSRGSPRDIHARMRIHNNRVGRQIVTDNMTRKCKCHGTSGSCQFKTCWHVSPEFRLVGSILKEKFLTAIFVNSQNKNNGVFNPRTENGASGTQGGLGGGRRRIMSRELVYFEKSPDFCEHDVSIDSPGTHGRICNKTSYSTDSCSSLCCGRGHNILKQTRSERCNCRFHWCCYVLCEECRHTEWVNVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQK5</accession>
    <name>A0A3P9DQK5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 26</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004551475.1">
        <property type="nucleotide sequence ID" value="XM_004551418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQK5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036734"/>
    <dbReference type="Ensembl" id="ENSMZET00005038021.1">
        <property type="protein sequence ID" value="ENSMZEP00005036734.1"/>
        <property type="gene ID" value="ENSMZEG00005027389.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475550"/>
    <dbReference type="KEGG" id="mze:101475550"/>
    <dbReference type="GeneTree" id="ENSGT00390000014794"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="317" mass="36219" checksum="3AC147C4D4861A30" modified="2019-02-13" version="1">MGLIKFISAIITRALFILIALIGVWRVTRVKEHDFYWLLTFLFLPLVLEMIITLRRRKGKDYKWFSPPIFLFLISIIPSMWLLELHHQQNKNSEPQCQKLDSLDLYNLIQNKTSRNLTITDSLKDIGNFFSAVCANDWILALHQILLILLIVGKWLLPLGGGVTRDELSQLLLIFVGTAADILEFTSETLSDIKDNNDMLVYVILGVWTWSMLQFPLHLAVVNSTPGREADQGAQESLLTKHSTDIWNIIQALFIQDGPFLCVRLTVMACFKVFHQMLVFFAIKNFLVVALNLYRFVVICQDFRTSSDNDAGGTAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRM2</accession>
    <name>A0A3P9DRM2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Complement C1q tumor necrosis factor-related protein 3-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRM2"/>
    <dbReference type="Ensembl" id="ENSMZET00005038213.1">
        <property type="protein sequence ID" value="ENSMZEP00005036923.1"/>
        <property type="gene ID" value="ENSMZEG00005027518.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000272155"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF102">
        <property type="entry name" value="CEREBELLIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018206545" evidence="5">
        <location>
            <begin position="22"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="91"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="181" mass="20232" checksum="FE05CED0645520F3" modified="2019-02-13" version="1">METILVFSVLLLACSISAAQTAEDEVILKKKIALLQPFTSDMEAVLTRIVASLAVQKEQITLLQKENREQEAKLKEVETQKTEIEQLKQRLQAKQVAFSASLVEHGGGTYTGPFNTETTLIFKRVVTNIGNAYNPYTGIFTAPVRGVYNFELTLHGHGDNAYPTAARLFMNKELIFTAWEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS52</accession>
    <name>A0A3P9DS52_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS52"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034602"/>
    <dbReference type="Ensembl" id="ENSMZET00005035815.1">
        <property type="protein sequence ID" value="ENSMZEP00005034602.1"/>
        <property type="gene ID" value="ENSMZEG00005025850.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005038572.1">
        <property type="protein sequence ID" value="ENSMZEP00005037269.1"/>
        <property type="gene ID" value="ENSMZEG00005027777.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176861"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08330">
        <property type="entry name" value="CARD_ASC_NALP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000013">
        <property type="entry name" value="Apoptosis-associated speck-like protein containing a CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033516">
        <property type="entry name" value="CARD8/ASC/NALP1_CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051249">
        <property type="entry name" value="NLRP_Inflammasome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985:SF2">
        <property type="entry name" value="APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="6">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="95" mass="10811" checksum="197F96D1A6570946" modified="2019-02-13" version="1">CGGTPKPMASAHFVDKHRVQLIQRVSNIAPILDELQYKEVIDQEQYDKIRALPTSQDKMRELYSGPLKASAACKDIFYESLLANEKFLVEDLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS55</accession>
    <name>A0A3P9DS55_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Unconventional myosin-Va</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567706.1">
        <property type="nucleotide sequence ID" value="XM_004567649.1"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005037113"/>
    <dbReference type="Ensembl" id="ENSMZET00005038409.1">
        <property type="protein sequence ID" value="ENSMZEP00005037113.1"/>
        <property type="gene ID" value="ENSMZEG00005027649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466683"/>
    <dbReference type="KEGG" id="mze:101466683"/>
    <dbReference type="GeneTree" id="ENSGT00940000155347"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15470">
        <property type="entry name" value="Myo5_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000002">
        <property type="entry name" value="Class V myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000003">
        <property type="entry name" value="Myosin-Va isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000001">
        <property type="entry name" value="unconventional myosin-Va"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058662">
        <property type="entry name" value="Myo5a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF273">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25966">
        <property type="entry name" value="Myo5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="16">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="69"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="14">
        <location>
            <begin position="1500"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1081"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1324"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1100"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1117"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="163"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1821" mass="210603" checksum="F05B4F428CE5E3AC" modified="2019-02-13" version="1">MAAAELYSKYARVWLPDAAEVWKSAELTKDYTPGDQTLSLQLEDGTKVEHKIDPRTNNLPPLRNPDILVGENDLTALSYLHEPAVLHNLKVRFIDSRLIYTYCGIVLVAINPYERLPIYDAAIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSSSGEANVEERVLASSPIMEALGNAKTTRNDNSSRFGKYIEIGFDTKYCITGANMRTYLLEKSRVVFQAHSERNYHIFYQLCASSHLPEFKAFRLGCADDFRCTNQGQSPVIDGVDDAKEMCNTRRSFSLLGIGESDQMEIYQILSAILHLSNVEVKDQSADRCSIKQDDVHLMVFCDLMGVPCEEMAHWLCHRKLKTTTETFVKPVPKINAIYGRDALAKYIYARLFSWIVDSINSALKSTVKQHSFIGVLDIYGFETFDINSFEQFCINYANEKLQQQFNLHVFKLEQEEYMKEEIPWTLIDFYDNQPCINLIEAKLGVLDLLDEECKMPKGSDETWAQKLYNTLLKQNAHFEKPRLSNRAFIIHHFADKVEYQCVGFLEKNKDTVNEEQINVLKKSKFDLLLKLFEDDEKAANSSNKLTSSIGRAGSAKKDTKKTVGLQFRQSLHLLMETLNATTPHYVRCIKPNDHKAPFTLDPVRAVQQLRACGILETIRISAAGFPSRWTYQEFFSRYRVLMKQKDLLPDRKQACKNLLEKLIKDQGKYQFGKNKIFFRAGQVAFLEKLRSDKLRMACVSIQKTIRCWLARKKYLRMRESAITIQKHVRGHQARCYAKFLLQTRAAIIIQRNVRMWSKRKLYQQQRSAAITVQCFWRAHMARKQYHKLMYEKKAIVIQKWVKGWLARQHYKRILAAIILLQSCVRRMRAKRELKKLKVEARSVEHFKKLNIGMENKILQLQHKINEQQKENRELSEKLSVTEKAQTMEIERQSSEIENLRRSEQETRAKAERLPSLLEQLSFLQHELENTRREKEDLEEQTKVYKEQTEQVVDELNTKNNLLKNDVDELNKQIVEQVQQLTEIQTNAENTKQLEEDLTEERSRYQSLLSEYLHLEERHRDLKEQMDLNTTSSKSSLKRTDSNYSSNSSEFSQSLGSTEGEDSSVQTEDETQTAVDLPVLLKLQRRVKELEQEKQSLWQQLDKREEDQQEKAKVVEEQRTSGRAELDLETLKRQELESENKKLKQDLNELRKSLTNENSDLVPPAPGSLPYKVLLEQLNSSTEELEMRKEEVLLLRSHLVRQEALKHKDSALGEGVKLDLSEIPSYQDVHKSTDIHTLNEDGELWLAYEGLKETNRLLEYQMHEQERVHNERYMKLVEEMNKLKDEKEQQQQMLAQSLLLPEDARIEASLKLEITRLTRENLELLEQQEKQDKTIRKLKKQLKLYMKKVEDFEVSTEQETRRSVVSPPGRAVNITRKEKEYQGMLEYKQGDESRLLKNLVIDLKPRGVAVSFTPGLPAYIIFMCVRYADIVNDDQRVSTLLNSTISSIKGVIKRRGNDFEVVSFWLANTCRLMHCLKQYSGDEVFMVHNTAKQNEHCLTNFELSEYQQVFGDLAIQIYRQLIKCMEDILQHLIVSSMLENETIQGVLGSKPTGLRKRSTSFSEEGAVTMEVLLQRLGLFHTTMSQHGMDSDLIKQVVKQQFYIICAVTLNHLLLRKDMCSWGKGLQIRYNVWQLEEWLAERELTDCGAKETLEPLIQAAQLLQIKKKTEADAQAICNMCTGLTTAQIVKVLTLYTPVIEFEERVSPSFITTIKNLLKDRAESSTLMMDAKKIFTVTLPFTPSSVALDTVQIPSSLNLGFLTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DUD1</accession>
    <name>A0A3P9DUD1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reactive intermediate imine deaminase A homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DUD1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037867"/>
    <dbReference type="Ensembl" id="ENSMZET00005039215.1">
        <property type="protein sequence ID" value="ENSMZEP00005037867.1"/>
        <property type="gene ID" value="ENSMZEG00005028251.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00420000029792"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="140" mass="14945" checksum="8D355782B5EF75A5" modified="2019-02-13" version="1">MAALIRRIISTAKAPAAIGPYSQAVVVDRTMYISGQLGMDPASGQLVEGGVQAQTRQALVNMAEILKAAGCGYTNVVKTTVLLADMNDFTSVNDTFMQLFFCALNPTENHNSHRTERLFLQGGLVEIEAIAVLGPLTDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DUP6</accession>
    <name>A0A3P9DUP6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DUP6"/>
    <dbReference type="Ensembl" id="ENSMZET00005039263.1">
        <property type="protein sequence ID" value="ENSMZEP00005037886.1"/>
        <property type="gene ID" value="ENSMZEG00005028299.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286981"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000253">
        <property type="entry name" value="Crooked legs, isoform H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001846">
        <property type="entry name" value="ZNF121 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="131" mass="15228" checksum="B738B3D738E9ADC6" modified="2019-02-13" version="1">DTDEDESKDGNSHRNKSETCGKRFIWKSDLTKHMRIHTGEKPHCCSSCGKRFTRKSHLKRHMQIHTGDKPHCCSTCGKRFTRKSHLNMHMRIHTGEKPHCCSTCGKRFTVKSHLNMHMRIHTGEKPHSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASJ4</accession>
    <name>A0A3P9ASJ4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASJ4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000690"/>
    <dbReference type="Ensembl" id="ENSMZET00005000763.1">
        <property type="protein sequence ID" value="ENSMZEP00005000690.1"/>
        <property type="gene ID" value="ENSMZEG00005000626.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234530"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF133">
        <property type="entry name" value="IMMUNE-TYPE RECEPTOR 5 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018143344" description="Ig-like domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="142" mass="15637" checksum="D007D568E2228B07" modified="2019-02-13" version="1">MLKPGAYCSLSLSVSLAVIGFSLFGHSEQKSVYVKQTPEAVSVHPGSSVTLQCSLFSNNNENRSECPDEHRVYWFRAGSGQSHATIIYTHRNYSQKQEGRRCVHSLSKTIQNSSDAGIYYCAVVTCGEIVFGEGTQVETSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATB1</accession>
    <name>A0A3P9ATB1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 138</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TMEM138</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM138 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553084.1">
        <property type="nucleotide sequence ID" value="XM_004553027.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004553085.1">
        <property type="nucleotide sequence ID" value="XM_004553028.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATB1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000960"/>
    <dbReference type="Ensembl" id="ENSMZET00005001039.1">
        <property type="protein sequence ID" value="ENSMZEP00005000960.1"/>
        <property type="gene ID" value="ENSMZEG00005000840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477374"/>
    <dbReference type="KEGG" id="mze:101477374"/>
    <dbReference type="CTD" id="51524"/>
    <dbReference type="GeneTree" id="ENSGT00390000018587"/>
    <dbReference type="OrthoDB" id="189688at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024133">
        <property type="entry name" value="TM_138"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13306">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13306:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14935">
        <property type="entry name" value="TMEM138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="162" mass="18937" checksum="2D81A0875063A026" modified="2019-02-13" version="1">MLQTGNFSLVLLIQLTLLAYDLFVNSFSELLRGAAVIQLVLFIIQDIAILFNVIIILLMMFNTYVFQVGLVSLLLERFRALLVFSTLYLTLSICFHCLVLNLRWLNSNSFVWTDGLQALFVFQRTAAVFYYYLYKRTAEYMGDPRLYEDSLWLRDAFARARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AU84</accession>
    <name>A0A3P9AU84_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbonic anhydrase 10</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Does not have a catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AU84"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000962"/>
    <dbReference type="Ensembl" id="ENSMZET00005001041.1">
        <property type="protein sequence ID" value="ENSMZEP00005000962.1"/>
        <property type="gene ID" value="ENSMZEG00005000607.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155223"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036269">
        <property type="term" value="P:swimming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03121">
        <property type="entry name" value="alpha_CARP_X_XI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000002">
        <property type="entry name" value="Carbonic anhydrase-related protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041878">
        <property type="entry name" value="Alpha_CARP_X/XI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018231045" evidence="3">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="334" mass="38239" checksum="6D7F1E70E7386DC5" modified="2019-02-13" version="1">KNLLWSVILRLKLWHFCSQPITSKLDDSWWAYKDVVQGSFVPVPSFWGLVNSAWNLCAIGKRQSPIDIETSHMIFDPYLTPLRLNTGGHKMGGTMYNTGKHVSLRPDKAHLVNISGGPLGYSYRLEEVRVHFGSEDSQGSEHLLNGQGFPGEVQLIHYNQDLYANYSEAAKSPHGIAVVSIFIKLSENSNAFLNRMLNRDTITRINYKHDAFLLMGLNIADLYPDTTRYITYEGSITIPPCYETSTWILINKPVYVTQMQMHSLRLLSQNEPYKIFLSMSDNTRPTQPLLQRCIRTNINFSKQGRDCPNNRALRPQYREWLLFVLGVCGNIVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUI8</accession>
    <name>A0A3P9AUI8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear receptor interacting protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
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                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004566092.1">
        <property type="nucleotide sequence ID" value="XM_004566035.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0G0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003212"/>
    <dbReference type="Ensembl" id="ENSMZET00005003341.1">
        <property type="protein sequence ID" value="ENSMZEP00005003212.1"/>
        <property type="gene ID" value="ENSMZEG00005002487.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476492"/>
    <dbReference type="KEGG" id="mze:101476492"/>
    <dbReference type="GeneTree" id="ENSGT00940000155984"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04139">
        <property type="entry name" value="RalA_RalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000203">
        <property type="entry name" value="Putative ras-related protein ral-a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="207" mass="23387" checksum="0A1EF4A02A495535" modified="2019-02-13" version="1">MAANKGKNQSSLVLHKLIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEAQIDILDTAGQEDYAAIRDNYFRSGEGFLLVFSITEPESFAATAEFREQILRVKAEEDKIPLLLVGNKSDLEERRQVPVDEARGKAEAWGVQYVETSAKTRANVDKVFFDLMREVRGKKMSENKDKNGKGKNKKNKKSFRERCCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B190</accession>
    <name>A0A3P9B190_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 179Ba</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554402.1">
        <property type="nucleotide sequence ID" value="XM_004554345.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B190"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003693"/>
    <dbReference type="Ensembl" id="ENSMZET00005003846.1">
        <property type="protein sequence ID" value="ENSMZEP00005003693.1"/>
        <property type="gene ID" value="ENSMZEG00005002862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485082"/>
    <dbReference type="KEGG" id="mze:101485082"/>
    <dbReference type="CTD" id="402849"/>
    <dbReference type="GeneTree" id="ENSGT00510000048151"/>
    <dbReference type="OrthoDB" id="8914435at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029776">
        <property type="entry name" value="TMEM179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31056">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31056:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="231" mass="25203" checksum="8804529A87ED0FB4" modified="2019-02-13" version="1">MMALAGLLVLEWGLYISCFVCGIVTAASVTIVQGNFGGHCMLYGAVSYNATSKLIGVQSSTSSSLCYFVSAISIMVAVVCFSLSVYWVYTFCSEGELKRENVWMNVIIAVSGVFLFFLLVTGCMLKIGRDTLCSSVTKNVPNTTSCEKAQSEKWASPLDGERFYSSLHKAETAVWINFFFWLIIGVLVIIQRRRGSASKLIGAAPTGSLFGETGVTPEETEPFFNRPGRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B291</accession>
    <name>A0A3P9B291_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho family GTPase 3a</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B291"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004026"/>
    <dbReference type="Ensembl" id="ENSMZET00005004189.1">
        <property type="protein sequence ID" value="ENSMZEP00005004026.1"/>
        <property type="gene ID" value="ENSMZEG00005003087.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157541"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000407">
        <property type="entry name" value="Rho-related GTP-binding protein RhoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="251" mass="28099" checksum="45DE13ABC31E7F28" modified="2019-02-13" version="1">MKERRSCQKLSLKSSMDPSQSVKCKIVVVGDSQCGKTALLHVFAKDCFPESYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVMKKWKGEIQEFCPNTKMLLVGCKSDLRTDLSTLVELSNHRQAPVSYDQVYGSNFLTLISMAKQISAPYIECSAQQSENSVRDIFHVATLACINKNNKNVKRSKTARASKRISHMPGRPDLAAVASDLRKDKAKSCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2G8</accession>
    <name>A0A3P9B2G8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin specific peptidase 54b</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2G8"/>
    <dbReference type="Ensembl" id="ENSMZET00005004275.1">
        <property type="protein sequence ID" value="ENSMZEP00005004105.1"/>
        <property type="gene ID" value="ENSMZEG00005003174.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155571"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052398">
        <property type="entry name" value="Ubiquitin_hydrolase_53/54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975:SF5">
        <property type="entry name" value="INACTIVE UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="277" mass="30656" checksum="111F7447497C1B8A" modified="2019-02-13" version="1">MLECREKPTPDMFGELLRNASNMGDLRNCPSNCGEVLRIRRVLMNSPEIVSIGLVWDSDHSDLAEDVIHSLGTCLRLGDLFYRVTEERARQAELYLVGMVCYYGKHYSTFFFQTKIRKWMYFDDAHVKEIGPKWKDVVSRCIKGHYQPLLLLYADPRGTPVILQESPNPCTSSNPQLELQHCSSKAGYDSEDSGREPSISSDTRTDSSTDSSSHRGSRSRSLHQSTGSHLSSESQTTVVCNYDTGTPPLGADAGGNAAGPNVLPLKKNAVAPSVKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B325</accession>
    <name>A0A3P9B325_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-box/LRR-repeat protein 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">F-box and leucine-rich repeat protein 16</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with SKP1 and CUL1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574703.1">
        <property type="nucleotide sequence ID" value="XM_004574646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B325"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004310"/>
    <dbReference type="Ensembl" id="ENSMZET00005004496.1">
        <property type="protein sequence ID" value="ENSMZEP00005004310.1"/>
        <property type="gene ID" value="ENSMZEG00005003333.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471080"/>
    <dbReference type="KEGG" id="mze:101471080"/>
    <dbReference type="CTD" id="146330"/>
    <dbReference type="GeneTree" id="ENSGT00940000159138"/>
    <dbReference type="OrthoDB" id="10044893at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22127">
        <property type="entry name" value="F-box_FBXL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000262">
        <property type="entry name" value="F-box/LRR-repeat protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000733">
        <property type="entry name" value="F-box/LRR-repeat protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
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        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 16"/>
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    <dbReference type="PANTHER" id="PTHR13318">
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            <begin position="344"/>
            <end position="433"/>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="501" mass="55313" checksum="8BA43CB6E8CDDFC5" modified="2019-02-13" version="1">MLNMSTPSELKSSCVTRNGMVKLPPSQPNGLGSASITKGTPAAKNRLCQSSSVPSILPPPPSSLSYHHHHLDGPGMPHAAAPLLPSEPGKPLVGLKPSLCQLPPLTLPKPVLLERQLVLDEKLLNRLLWYFTTAEKCVLAQVCKTWRKVLYQPKFWEGVTPILHAKELYTLLPNGEKEFVSLQAFALRGFQSFCLVGVSDLDICEFIDNYPLSKKGVRSVSLKRSTITDAGLEVMLEQMQGLMHLELSGCNDFTEAGLWSSLNARLTSLSVSDCINVADDAIAAISQLLPNLSELTLQAYHVTDTAMAYFTAKQGYTTHTLRLHSCWEITNHGVVNMVHSLPNLTSLSLSGCSKITDDGVELVAENLRKLRSLDLSWCPRITDMALEYIACDLHKLEELVLDRCVRITDTGLGYLSTMSSLRSLYLRWCCQVQDFGLQHLFGMRSLRLLSLAGCPLLTTTGLSGLIQLHELEELELTNCPGATAELFKYYSQHLPHCMVIE</sequence>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B408</accession>
    <name>A0A3P9B408_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="359" mass="36742" checksum="66978EFF92F66214" modified="2019-02-13" version="1">MWSSSCSTLSPEPLTLSLRERPATLRRKLIFAACIRDLVLSLQPSSAFAGGCEGPLQPSSAFAGVSEGPLQPLFVFAGGPRDRSSLRPPSMEGPRDRSSLCLSSLGGPRDRSSLRPPSLGGPRDSSSLCLSSLGGPRDRSSLRPPSMEGPRDRSSLRPPSLGGPRAFAGGCEGPLQPSVRSSSLGGPRDSSSLRPPSLGGPRYRSSLRPPSLGGPRDSSSLCLSSLGGPRDRSSLRPPSLGGPRDSSSLCLSSLGGPRDRSSLHPPSMEGPRDRSSLRPPSLGGRGPSLEGARDRSSLRPPSLGGPRAFAGGCEGPLQPSSAFAGGPEGPLQPSLQPSSAFAGGSEGPLQPSSAFAGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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            <taxon>Vertebrata</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A3P9B665"/>
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        <property type="protein sequence ID" value="ENSMZEP00005005383.1"/>
        <property type="gene ID" value="ENSMZEG00005004170.1"/>
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        <property type="component" value="LG14"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PBP1_CaSR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Olfactory receptor C family, h1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
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        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
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        <property type="entry name" value="GPCR_3_C"/>
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        <property type="entry name" value="GPCR_3_CS"/>
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        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
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        <property type="entry name" value="Peripla_BP_I"/>
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    <dbReference type="PANTHER" id="PTHR24061:SF418">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCQ19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
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        <property type="entry name" value="ANF_receptor"/>
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    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
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        <property type="entry name" value="VOMERONASL2R"/>
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    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
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    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
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    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
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    <feature type="chain" id="PRO_5018125996" evidence="13">
        <location>
            <begin position="21"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="766"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="801"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="833"/>
            <end position="856"/>
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    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="606"/>
            <end position="871"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="874" mass="96995" checksum="B2D977070B5C43A0" modified="2019-02-13" version="1">MRTNLLLLVLLSCYFTSVISFSQFSLSCQLQGQFDLNGMYKTGDVVLGGLFQIHFFSSVAIQSFTSQPQQPTCSGVYALGFKLAQTMAFAIDEINRNSNLLPNVTVGYTLYDSCQELGIGFRAALSLANSQEEKIILNDTCSGNPPVIGIVGDPSSTPSIAISSVLGLYRVPMVSYFATCSCLSDHQKYPSFFRTIPSDAFQVRAMIQILKHFGWTWVGLLVTDDDYGLHAARSFQSELSLSGESCLAYTEVLPWSKDTDELRRIVDVMKKSTARVVIVFEHYSRVINLMEEVVRQNLTGIQWMASESWTVAVPDVLQTPQLMPYLGGTLGIAIRRGEIPGLREFLLQIRPDRHHNNSYGNSMVNQFWEFAFQCRFAPAPAGWLEGEGAICTGQEDLKNVDNEFLDVSDLRPEYNVYKAVYALAYSLDEMLRCKPGRGPFSGNSCATLQSLEPWQLIYYLERVNFTTPFGDQVSFDENGDVEPIYDVMNWLWLPDGSTKVQSVGEVKGSGEGEELILDENRIFWNFESKKPPQSVCSENCPPGTHMVREKGKPQCCFDCIPCSEGKITNKSNSLECTSCPEDFWSNPQRDHCIPKKTEFLSYHDPLGICLMATSLLGTFICAVVLGIFICHRTTPIVRANNSELSFQLLVSLKLCFLCSLLFIGRPRLWTCQLRHAAFGISFVLCVSCILVKTMVVLAVFKASKPGGGTSLKWFGAMQQRGTVLFLTSIQAAICTTWLVSSSPTPHKNTQYHNDKIVYECAVGSTVGFAVLLGYIGMLAFLSFLIAFLVRNLPDSFNEAKLITFSMLIFCAVWVAFVPAYVSSPGNLADAVEVFAILASGFGLLITLFGPKCYIILLRPELNTKKAVMGRGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6D1</accession>
    <name>A0A3P9B6D1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1. Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end 5'-phospho-ribonucleoside-RNA + 2 S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:58640"/>
            <dbReference type="Rhea" id="RHEA-COMP:15179"/>
            <dbReference type="Rhea" id="RHEA-COMP:15182"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:142777"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5'-end 5'-phospho-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:58656"/>
            <dbReference type="Rhea" id="RHEA-COMP:15179"/>
            <dbReference type="Rhea" id="RHEA-COMP:15181"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:142776"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6D1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005347"/>
    <dbReference type="Ensembl" id="ENSMZET00005005576.1">
        <property type="protein sequence ID" value="ENSMZEP00005005347.1"/>
        <property type="gene ID" value="ENSMZEG00005004155.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153993"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000632">
        <property type="term" value="P:negative regulation of pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000138">
        <property type="entry name" value="BCDIN3 domain containing RNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF1">
        <property type="entry name" value="RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="12">
        <location>
            <begin position="48"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="258" mass="29937" checksum="E4F94D928FB49A9C" modified="2019-02-13" version="1">RTRFRKVQTQRPYQRLPLPWRQAERQLVATLAHPCLLEPRALDFNPPENRLSLIPPALLRDLGYSDETTLIVDVGCNSGELSIAFYKHLVPEEQPDRRKVHLLGFDLDETLVQRAEEINPLPSRITFIPLDITKDTNQLQDYLSLHGCSHFHLCLCLAVTMWVHLNHGDLGLLQLLSRLSSMSQHLLLEAQPWKCYRSAARRLRKLGRSDFDHFKTLKIRGDVADHAREHLERHCGMELIQSFGSTAWDRKLLLFRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6R4</accession>
    <name>A0A3P9B6R4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerophosphodiester phosphodiesterase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559422.1">
        <property type="nucleotide sequence ID" value="XM_004559365.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6R4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005599"/>
    <dbReference type="Ensembl" id="ENSMZET00005005838.1">
        <property type="protein sequence ID" value="ENSMZEP00005005599.1"/>
        <property type="gene ID" value="ENSMZEG00005004336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475968"/>
    <dbReference type="KEGG" id="mze:101475968"/>
    <dbReference type="GeneTree" id="ENSGT00510000047820"/>
    <dbReference type="OrthoDB" id="197419at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006580">
        <property type="term" value="P:ethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08573">
        <property type="entry name" value="GDPD_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46320:SF1">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="67"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="333" mass="37618" checksum="B86805206D140BA8" modified="2019-02-13" version="1">MLQIGDEVVYFSVVFLLVVLVTRSATWATLLTAFLYIFMVMFRFPPVPADRAARVLRPGALSSGGGVPVVAHRGGSHDAPENTLAAIREASRNGATGVELDLSFTADGVPVLMHDETVDRTTNGSGPISKLQFVQLRRLNAAAHHRMKDRFNVEKVPTLQEAVEECIRHQLTIFFDVKGQPDMAVSVLHNMFKKFPVLYNSSVVSSFEPKVIYKMRQTDPHVITALTHRPWRLSRFGDGTPRSLSTWSQLWTGVLDVLLDWAHHRVLWKLCGISAILVQKDFISRDYVQYWAERGVEVVGWTVNTAVEKEYYQNLLKISYMTDSLLEDCDPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6S9</accession>
    <name>A0A3P9B6S9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Extracellular calcium-sensing receptor-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6S9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005608"/>
    <dbReference type="Ensembl" id="ENSMZET00005005848.1">
        <property type="protein sequence ID" value="ENSMZEP00005005608.1"/>
        <property type="gene ID" value="ENSMZEG00005004320.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165453"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000302">
        <property type="entry name" value="Si:ch211-203b20.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF415">
        <property type="entry name" value="NOVEL PHERMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018041517" evidence="13">
        <location>
            <begin position="30"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="830"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="603"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="867" mass="95782" checksum="9F8D6566302E46EA" modified="2019-02-13" version="1">MAASTFWLPLQPTKWLSSALSLLLVSIMGKPVGLQGVQATVCSQLGAPSDRGVFQDGDVIIGGLFSLHYIPSAVEQDYTRLPHYEPCSGLDLQALKYMYAMAFAVEEINQNSALLPGIKLGYHILDSCGRYPWALQSALSLVGGDRHSCNLTPVPLLIGGHASTTGVILSRILGPLSVPVISYLASCPCLSDRSNFPNFFRTIPSDIYQARTMAQMAIRLNWTWIGAVLANNDYGQKAIQEEIKGKRVCLEFIETVHRETIVSDARRVALTIQSSTATVILIFCWYTDVQKIFVELAKRNVTGRQFLASEAWSTSDDLLQDITISKVASGVVGVAIRSSTIPGFENYLKKLSPSHRPDDEFLREFWEKEFGCSIVNASHNTSTSSHVKKASIPPCSGTESINEVQHFFSDITQLRVVYNVYLAVYAAAHALHSLLSCPNFNKLNTIKHFIFSILYFQLLQHLNTVNLTTPQGEVFYFQGGDPPAKYDLVNWQNTPKGTLKLVVVGHVDGFDLHLNESAIQWSTGSNQVPDSVCSKSCRPGTRMTDRKGEPVCCFDCIPCAEGEISNKTDSLQCEQCPSEFWSNVERIACIPRQLDFLSFNETLGITLTTAAVSGVSVTTTVFVVFLFYRQTPMVRANNSELSFLLLLSLKLCFLCSLVFIGRPSVWSCRFQQAAFGISFVLCVSCLLVKTIVVLAVFRSARPGAETLMKWFGPGQQRGSVCFFTCIQVIICVIWLSLSPPRPQSDFGFQGSKVTLECTMESVVGFSLVLGYIGLLACTCLLLAFLARKLPDNFNEAKLITFSMLIFCTVWVSFVPAYISSPGKYVVAVEVFAILASSYGLLLCIFAPKCFIILLRPEKNTKKHLMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAR0</accession>
    <name>A0A3P9BAR0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit rho-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">GABA(A) receptor subunit rho-1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
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    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
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        <text evidence="18">Three rho subunits (rho-1/GBRR1, rho-2/GBRR2 and rho-3/GBRR3) coassemble either to form functional homopentamers or heteropentamers. Rho-1/GBRR1 subunits can also associate with alpha-1/GBRA1 subunits to form a functional GABAAR. Interacts with SQSTM1.</text>
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            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="17">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily.</text>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAU2</accession>
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        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
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                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAU2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007019"/>
    <dbReference type="Ensembl" id="ENSMZET00005007326.1">
        <property type="protein sequence ID" value="ENSMZEP00005007019.1"/>
        <property type="gene ID" value="ENSMZEG00005005401.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101482682"/>
    <dbReference type="GeneTree" id="ENSGT00940000159619"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11459">
        <property type="entry name" value="bHLH-O_HES1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="9">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="247" mass="26560" checksum="2429903EB8EF075D" modified="2019-02-13" version="1">MPAGTLERASPSAVAATPTSGDSTPEKPRALTESRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRLQMTAAANTDPFVLGKYRAGFSECVGEVTRFLSTCEGVNTEVRTRLLSHLAACVAQINTLNFYGPHLGAVGLGQTGTQIPVASVPQIPCKSNSLMHAPPESMKLYGGFQVVPTPDGQFAFLVPSAALGPLTAQNGHHVSPVAPAVTSDSVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BB37</accession>
    <name>A0A3P9BB37_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Diacylglycerol lipase-beta</fullName>
            <ecNumber evidence="16">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">PUFA-specific triacylglycerol lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Sn1-specific diacylglycerol lipase beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1,2,3-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + H2O = 1,2-di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:77016"/>
            <dbReference type="ChEBI" id="CHEBI:147311"/>
            <dbReference type="ChEBI" id="CHEBI:228170"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2,3-tri-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63432"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:147308"/>
            <dbReference type="ChEBI" id="CHEBI:228166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63433"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="16"/>
    <dbReference type="RefSeq" id="XP_004557533.1">
        <property type="nucleotide sequence ID" value="XM_004557476.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BB37"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006991"/>
    <dbReference type="Ensembl" id="ENSMZET00005007299.1">
        <property type="protein sequence ID" value="ENSMZEP00005006991.1"/>
        <property type="gene ID" value="ENSMZEG00005005390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487957"/>
    <dbReference type="KEGG" id="mze:101487957"/>
    <dbReference type="CTD" id="221955"/>
    <dbReference type="GeneTree" id="ENSGT00940000156486"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000064">
        <property type="entry name" value="Sn1-specific diacylglycerol lipase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF2">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="25">
        <location>
            <begin position="375"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="676" mass="74471" checksum="817A674067BE359F" modified="2019-02-13" version="1">MPGMVVFGRRWGIASDDLVFPGSFELFIRILWWIGTMVLFIYHKGHFECNGRAVLHSYLVGLLVVLALIILSLCAIVYISAQGTITNPGPRRSMPALVYLRAILYVPELVWACLGAVWVSDDGRGCDPATVGAVISAVVASWIILLFTAVGVVFVFDPLGNPRPQPPAMEPLGVRDMQSSEGTQFLSTARSLAVKVWESRLRLLCCCLPQDESSRAAFSSISQLFSSFFSDTDLVPSDIAAGLALLHQEQDKMERSRDPDVVVPHSPSSPVGEDLEDELEKATHWMQFAAAAYGWPLYIYSNLFTGPCKLSGDCCMSRVAEDEIVGGDHLGCHFSSILQTTGLQYRDFIHVSFHNQIYEIPFFVALDHKREAILVAVRGTLSLKDVLTDLSAECENLPVEGVLGACYAHKGISQAAGYVYKRLVNDGILNQAFSIAPEYKLVITGHSLGAGAASVLAILLRNSFPTLQCYAFSPPGGLLSKALADYSKDFVVSVVLGKDLVPRLSIPNMEDLKRKLLKIVSNCNKPKYRILLQGCWYELFGGDPDDCPTEMDNRREQELSQPLLGEESLIVRHSSSYQSLGSDESPAHTPAHLPLFLPGRILHITEDGPTRRSCFSQVRYRADWSNEMAFRSILISPRMLTDHMPDIVLRALGTLTKDKPFSLCPSSLSDSQHNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBD6</accession>
    <name>A0A3P9BBD6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Iduronate 2-sulfatase</fullName>
            <ecNumber evidence="15">3.1.6.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Alpha-L-iduronate sulfate sulfatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.</text>
            <dbReference type="EC" id="3.1.6.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer. The 58-kDa mature form is composed of two chains resulting from proteolitic processing, the 42-kDa chain and the 14-kDa chain that remain stably associated and form the 58-kDa intermediate form which is enzymatically active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.13" evidence="15"/>
    <dbReference type="RefSeq" id="XP_004563205.1">
        <property type="nucleotide sequence ID" value="XM_004563148.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBD6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007202"/>
    <dbReference type="Ensembl" id="ENSMZET00005007512.1">
        <property type="protein sequence ID" value="ENSMZEP00005007202.1"/>
        <property type="gene ID" value="ENSMZEG00005005543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484170"/>
    <dbReference type="KEGG" id="mze:101484170"/>
    <dbReference type="CTD" id="3423"/>
    <dbReference type="GeneTree" id="ENSGT00940000156803"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004423">
        <property type="term" value="F:iduronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16030">
        <property type="entry name" value="iduronate-2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000027">
        <property type="entry name" value="iduronate 2-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035874">
        <property type="entry name" value="IDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018061058" description="Iduronate 2-sulfatase" evidence="19">
        <location>
            <begin position="24"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="20">
        <location>
            <begin position="28"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="559" mass="63104" checksum="A0C977E2A88C6D0F" modified="2019-02-13" version="1">MDIFVLRCFFLLVLHTSTYPAAAGRERKNVLFIMADDLRTSLGCYGDPVAKSPNIDQLASRGQVFLNAFAQQAVCGPSRVSMLTSRRPDTTRLYDFNSYWRVHSGNYTTLPQYFKSQGYLTMSVGKVFHPGIASNNTDDYPYSWSIPAYHPPSFTYEKKKMCKGKDGKLHVNLLCAVNVSEQPGGTLPDLESTEEAVRLLKSRVNDDDPFFLAVGFHKPHIPFRIPQEYLTLYPLDQMTLAPDPDVPERLPTVAYNPWTDIRKREDVQKLNISFPYGSIPKDFQLRIRQHYYAAVSYMDAQVGRLLSALEELGLADNTMVVFTSDHGWSLGEHGEWAKYSNFDVATRVPLIFSVPGGNEAGTSTFPFIDVLRESVHSIKSGKVRSRVVELVDVFPTVSYLAGLEVPVQCPDISFQVELCTEGENRAYAAPQGRSERTPEDVAFSQYPRPADAPQENSDLPDLKDIKIMGYSLRTWDYRYTLWLGFNPKTFQVNVSDVHAGELYMSADDPGQDKNIFNNSDYSEIMRKTASLPQTVGLQMRMKLEFHYLTAGMKTSRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBR2</accession>
    <name>A0A3P9BBR2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Collagen and calcium-binding EGF domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004539790.1">
        <property type="nucleotide sequence ID" value="XM_004539733.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBR2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007334"/>
    <dbReference type="Ensembl" id="ENSMZET00005007644.1">
        <property type="protein sequence ID" value="ENSMZEP00005007334.1"/>
        <property type="gene ID" value="ENSMZEG00005005633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465403"/>
    <dbReference type="KEGG" id="mze:101465403"/>
    <dbReference type="GeneTree" id="ENSGT00390000014907"/>
    <dbReference type="OrthoDB" id="9946071at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
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        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUTICLE COLLAGEN DPY-2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018080726" evidence="5">
        <location>
            <begin position="28"/>
            <end position="389"/>
        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="215"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
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        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="389" mass="41545" checksum="2C0F98ADA9B04B99" modified="2019-02-13" version="1">MGQLYGATLLPFCVFCVVFLWESGASSIRTTLAMDTSGMECPDNKILTVEYPCIRADGKNGTCFRRKCCKGFRFVMGQCIPESVDVCAASPCEQQCTDNFGRVVCTCYPGYRFDRERHRNHKSPYCLDIDECEAPSSSLCDQECVNTVGSFECRCRSGYILASDQRSCIAIHNLSSSGKSDTLMSSGTCSFTCQDFMNMKNSLLQLKLKLGNTHSPNQVPGLANSSNKPSLGRAGKKPDGPCLSGLPGPPGAPGVPGHPGQPGMRGDLGERGPPGPPGPRGDMGPMGPEPDLKHIKRGRRGAVGPPGAPGRDGLKGDRGAPGPRGPPGPPGSFDFLLLMMADIRNDIIELQEKVFGEQRGISLDSPPHNSGEADFVEWGSGKGDHMLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCP4</accession>
    <name>A0A3P9BCP4_9CICH</name>
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        <submittedName>
            <fullName evidence="12">Uncharacterized LOC101482322</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004552729.1">
        <property type="nucleotide sequence ID" value="XM_004552672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCP4"/>
    <dbReference type="Ensembl" id="ENSMZET00005007997.1">
        <property type="protein sequence ID" value="ENSMZEP00005007679.1"/>
        <property type="gene ID" value="ENSMZEG00005005871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482322"/>
    <dbReference type="KEGG" id="mze:101482322"/>
    <dbReference type="GeneTree" id="ENSGT00990000203779"/>
    <dbReference type="OrthoDB" id="8654606at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042129">
        <property type="term" value="P:regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040216">
        <property type="entry name" value="CTLA4/CD28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11494">
        <property type="entry name" value="CYTOTOXIC T-LYMPHOCYTE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11494:SF9">
        <property type="entry name" value="SI:DKEY-1H24.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017922594" evidence="11">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="214" mass="24572" checksum="D9F1A0932B1AAE4E" modified="2019-02-13" version="1">MRISWMFMCLLVCKSSYGTQDQSDSNCDWSGLTLHDSSNDNVTVTCPLILPKDEEISFYLLKDKDMIYSHTCKQNCTGMKWDAGELHTNGSHWFFTVKLGHNIRGLYRCNITRAYPPPLTKDYGDPVLVIEFPHQCPTPTCNPTGDAPNTSQEWIWIMVIAIVSIYGVTVSIIAMCNWLKLKNTENQSDYMNTKPRAPRDRKKKKGLQNIQRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEY7</accession>
    <name>A0A3P9BEY7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine-rich protein 2-like</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEY7"/>
    <dbReference type="Ensembl" id="ENSMZET00005008795.1">
        <property type="protein sequence ID" value="ENSMZEP00005008457.1"/>
        <property type="gene ID" value="ENSMZEG00005006447.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158683"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09476">
        <property type="entry name" value="LIM1_TLP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000025">
        <property type="entry name" value="Cysteine-rich protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074:SF5">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="76"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="194"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="277" mass="30414" checksum="72C83BF2621ABD4B" modified="2019-02-13" version="1">MYIFVWWVASCMMSPRGRSYTIEREEAEGGCEAQSHHSHRRRQHHLRCVCAAGAADRQKGPTEKDPVPLFTPTMASKCPKCEKTVYFAEKVSSLGKDWHKFCLKCERCNKTLNPGGHAEHDGKPYCHKPCYATLFGPKGVNIGGAGSYVYDNPVNEAPAAVSLETNAKPEEEKKAPARGPVKAASFSSFSGGPNICPRCNKTVYFAEKVSSLGKNWHRPCLRCERCNKTLAPGSHAEHDGQPYCHKPCYAVLFGPKGVNTGGVGSYIYDDPEAEAQS</sequence>
</entry>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Neoteleostei</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BFK8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008677"/>
    <dbReference type="Ensembl" id="ENSMZET00005009017.1">
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        <property type="gene ID" value="ENSMZEG00005006603.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235147"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="74" mass="8245" checksum="048E382100D794FB" modified="2019-02-13" version="1">MAGYTGLRSCTWTEFPAHVFNSSSLLTQGSAASSCDLTLLTCLLIGSYRFCIIPLLAIIFFLSLLYKHVYITCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BG10</accession>
    <name>A0A3P9BG10_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Fan S."/>
                <person name="Simakov O."/>
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                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Rakotomanga M."/>
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                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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                <person name="Streelman J.T."/>
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            <dbReference type="PubMed" id="25186727"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BG10"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008823"/>
    <dbReference type="Ensembl" id="ENSMZET00005009164.1">
        <property type="protein sequence ID" value="ENSMZEP00005008823.1"/>
        <property type="gene ID" value="ENSMZEG00005006699.1"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="CD_Cbx6"/>
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        <property type="entry name" value="Chromobox protein homolog 7"/>
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        <property type="entry name" value="PcG_PRC1-like_component"/>
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        <property type="entry name" value="CHROMOBOX PROTEIN HOMOLOG 6"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR46389">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17218">
        <property type="entry name" value="CBX7_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="10"/>
            <end position="68"/>
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            <end position="182"/>
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            <begin position="91"/>
            <end position="104"/>
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            <begin position="350"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00022491"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50013"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008823.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="508" mass="54294" checksum="24717EB1795806EA" modified="2019-02-13" version="1">MELSAGDRIFAAEAILKRRVRKGRLEYLVKWKGWAMKHSTWEPEENILDDRLILGFEQKERERELHGPKKRGPKPKNLVMKARGQKGESGSRASNTRQTTLRPTSSTSNRAASSSSSASAHLLPSSSSSAVAPSPKLNSLAATHKLKKDIHRCHRMSRRPLPRTDPMATTFSNPGGFPSRMHVSPFSETVRILNRRVKPREVKRGRIILNLKVIDKAGRGGTAAGGRNISAGRQNIPSRNRIIGKKREAPYRPFQPPLKMLGFPMYGKPFGLQCGGPVPFHSHPSSCSSTGARESRTSPSQFQAPPSPSSSSGSEGKSPTNATAAQSQPSTGASPSSKDPKSSKPHADTQKSQSTKSSTPAASSDANQAASSSSPFLPSSPSSSLEDEEDEGAPDRTVPSEEGRKNPRQCRAKHQLPTALPPATPGDQTSAPTEPPRVPAEGDPDWHPEMAPSCKDVVVTDVTTNLVTVTIKEFPSPASCPASPSASPENASSPPPTAASDDPSPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGF4</accession>
    <name>A0A3P9BGF4_9CICH</name>
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        <recommendedName>
            <fullName evidence="16">Anthrax toxin receptor 1</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell projection</location>
            <location evidence="14">Filopodium membrane</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cell projection</location>
            <location evidence="13">Lamellipodium membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012776288.1">
        <property type="nucleotide sequence ID" value="XM_012920834.2"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005009004"/>
    <dbReference type="Ensembl" id="ENSMZET00005009351.1">
        <property type="protein sequence ID" value="ENSMZEP00005009004.1"/>
        <property type="gene ID" value="ENSMZEG00005006818.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101474504"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157727"/>
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        <property type="component" value="LG8"/>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:filopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:lamellipodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="vWA_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anthrax toxin receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR008399">
        <property type="entry name" value="Anthrax_toxin_rcpt_C"/>
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    <dbReference type="InterPro" id="IPR008400">
        <property type="entry name" value="Anthrax_toxin_rcpt_extracel"/>
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        <property type="entry name" value="VWF_A"/>
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    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059">
        <property type="entry name" value="ANTHRAX TOXIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16059:SF16">
        <property type="entry name" value="ANTHRAX TOXIN RECEPTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05586">
        <property type="entry name" value="Ant_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05587">
        <property type="entry name" value="Anth_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
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    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
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    <feature type="chain" id="PRO_5018106534" description="Anthrax toxin receptor 1" evidence="20">
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            <begin position="28"/>
            <end position="565"/>
        </location>
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            <begin position="321"/>
            <end position="342"/>
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            <begin position="46"/>
            <end position="214"/>
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            <end position="414"/>
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            <begin position="475"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060389"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="565" mass="62409" checksum="51F7126544E11A15" modified="2019-02-13" version="1">MARFLLNISLVLVLFGLFLLSFPSARAEPGLLDEEEEESSCQGAFDLYFVLDKSGSVKDHWNEIYEFVKNLAEKFKSPMLRMSFITFSSRASIILKLTENRVDITKGLNALNREVPGGDTFMHLGLQLANQQIRKENFGTASVIIALTDGELHEHQLRDAQHQANEARSLGAIVYCVGVKDFNETQLATIADTIEHVFPVLGGFHALRGVIDSIIKKSCIEILAAEPSSVCAGESFQVVVKGNGFLHARNIDQVLCSFKINDTITINEKPADVEDTFLLCPAPVIDEVGKVIYLQVSMNDGLSFISSNVHITTTECFDGTILLITLLALFLLLALLFLWWFWPLCCTVVIKEPPPPPPPEPESDDDDDGLPKKKWPTVDASYYGGRGIGGIKRMEVRWGGKGSTEEGAKLEKPKNAVVKMPEQEYEPYEPKPKKPQNKKPPQSRKWYTPIRGKLDAIWALFRRGYDQVSLMRPQPGDHGRCINFTRVKEESAAAKAPPRTPIHTPSPPPPDYRPITRTTPPSTTATSPPARSPPSGQVPPGPPPSRTPPGLPCAPPSRPPPSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGF7</accession>
    <name>A0A3P9BGF7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tektin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539120.1">
        <property type="nucleotide sequence ID" value="XM_004539063.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004539121.1">
        <property type="nucleotide sequence ID" value="XM_004539064.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004539122.1">
        <property type="nucleotide sequence ID" value="XM_004539065.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGF7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008973"/>
    <dbReference type="Ensembl" id="ENSMZET00005009318.1">
        <property type="protein sequence ID" value="ENSMZEP00005008973.1"/>
        <property type="gene ID" value="ENSMZEG00005006802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475775"/>
    <dbReference type="KEGG" id="mze:101475775"/>
    <dbReference type="CTD" id="150483"/>
    <dbReference type="GeneTree" id="ENSGT00950000182894"/>
    <dbReference type="OrthoDB" id="5788000at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF12">
        <property type="entry name" value="TEKTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="442" mass="50498" checksum="C106C0DB526EA173" modified="2019-02-13" version="1">MCSDVVVSRPHYDSRAVAQGVPEKDHLVAAPQPSSGLATAGYRSAKYTPTEWFSNYQNLLQQAGTDCHEATSLQRESRTLYQDTDASTFKTQAEGTRRLGERLQEIHYWKSELQRHIEQLLADTESLVALKMRLEKALDATEIPYAIATDNLNCRARRLGADLVRDTVEEELFKEVDLIRSVQALLKRTTAQVVSQIKLNREAKHTLEMDWSDKYQAYHFDDHSGRHSNMSSDTQHHPSSAAMQEQVSSHPLWTKFTQDNLFKAVQEEQATNSLRLLVEQVLQDTAEDLRVQCSSVDRAFSERCVELNEAKTQLNMQLKQILEQIGAQEKNIVALQQAIHNKEAPLRVAQSRLYLRSLRPNMELCRDEPQLSLEGEVKQIDATLASLQQKLSKARESLSRLEESRMALEKDINCKTHSLFIEREKCMTHRKRYPTTSALSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIU3</accession>
    <name>A0A3P9BIU3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SET binding factor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005009850"/>
    <dbReference type="Ensembl" id="ENSMZET00005010213.1">
        <property type="protein sequence ID" value="ENSMZEP00005009850.1"/>
        <property type="gene ID" value="ENSMZEG00005007421.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155263"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01235">
        <property type="entry name" value="PH_Sbf1_hMTMR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000093">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.200:FF:000004">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000006">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF16">
        <property type="entry name" value="C-MYC PROMOTER-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="7">
        <location>
            <begin position="7"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="8">
        <location>
            <begin position="1052"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="1689"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1542"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1542"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1795" mass="201928" checksum="B7FCECF9EDFD849B" modified="2019-02-13" version="1">MARLADYFVVVGYDLEKRGGCEGQGRILQRFPEKDWEDSPFPQGVELFCQPSGWQLVPDQLPPSFFVAVLTDINSDRHYCACFTFWEGLDNPQLQKAEASEADEADEVLSVVQPAKIFAPKSLVLVSQLDHTEVFRNCLGLIYTVHVDGLSAPLETVVGNLLTCVIPIAGGSQRTITLGAGDRQVIQTPINESLPVSGSSVAQLFRQLGIANVLCLFCAALTEHKILFLSSSYQRLTDACRALLAIMFPLKYSFTYIPILPGKLLEVLSTPTPFIIGVNSFFRSETQELLDVIIADLDGGTVTIPECVHISLLPEPLLQQTQTALSMVLDPELEVADHAFPPQSTQPSALKIQDKEIRAVFLWLFARLFQGYRWCLHIIRIHPEPVIRFHKAAFLGQRALSEDDFLTKVLDGMAFAGFVSERGPPYRATDLFDDLVANQVERIRQEEACPHKVMNHAKEVAEQLFKNENPYPAVAMHKIQRPSENSQNNAQNRAPFPMLDDVAVQLFIDHAAAKLKTAPPAVKPELKSMVPSGPPLGELFLAYIVDRNGNVMANSARRLEVVRNCITYIFENKMLEAKKLMPAVLRALKGRAARVCLTQELNQHVLQNRAVLDDQQFDYIVRMMNCTLQDCSHMDEHGIAAALLPLVTAFCRKLGAGVTQFAYSCVQEHMVWTNMQFWEAMFYSDVQNHIRHLYLETEDGGQEIGALELASEQSRLWPTLSKEMQMERVQKEESTVFSQAIHYANRMSYLLLPLDTSKNRLLRSSGLGDVESVSNSYVTNSIAGSMAESYDTESGFEDAESSDVANSVVRFINRFVDKVCNESGVTNEHLKALHAMIPGMDESPRLPRPKLLRPTLLPGEELVMEGMRVHLIPDGREEATGLMGGPPLLPAEGAIFLTTYRLIFKGTPTDPLGKRNFGCSSVDCPVLSLTAVSSCTFLRITKHLHKLRYPQHVQGTFAFTVGQSGKMVVEHKTKDKNQSLKTLSKNLVKSAKRTIGRQYVTRKKYSPPTWENRSSFQSELDEDEISVSEEVDQSSLTLSSTIRSSDRQTMSNVVERACCRDYQRLGLGTLSNSLTRSKNEPFRISTANRMYTVCRSYPGLLIVPQSIPDSTINRICRCYRQNRFPVVCWRNPRTKAVLLRSAGLHAKGVVGFFKSPNAPTAVPSQADSTSLEQEKYLQAIISSMPSYSENSGRNTLSGFTSTHMNTSGKWGSIRGSGRLSAYNPDVGTRLAGKESPQPNGGPSEAMFLRQQKAYLYIIGDKAQLKGGKQDSFQQWEVVPIEVCDVRQVKNSFKKLMKACVPSSSTSDPNMSFLRCLEESEWMALLHRVLQVSVLVVELLDTGSSVMVSLEDGWDVTTQVVSLVQLLSDPYYRTFDGFRLLVEKEWLSFGHRFSHRGAQTLGSQSSGFTPIFLQFLDCVHQIHLQFPMEFEFSQYYLKFLAYHYVSNRFRTFLLDSDYERIELGVLYEEKGERKNPQVCKSVWDYIDRLNKKTPVFYNYMFSPEDDEVLRPYTFISNLKVWDFYTEETLSEGPSYDWELRGRQERAAEETAEKPDTSGPKSQRHIVWPCYDNLTKVVPDAITKLLQDLQSLEAELGQATDKWKDTWDKIKTTQRTETKLESKPSFSSSLLMSSNLSHQRRSQGVYLQESGVGSSINLALDCEASATSTPVPGRPSTSTLYSQFQSSESENRSFEGILFKRGALLKPWKPRWFVLDKTKHQLRYYESRQDKECKGVIDLAEVESVTAGTPTMGAPKNIDEKAFFDLKTTKRVYNFCAQDSLNAQLWMDSVQSCLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ56</accession>
    <name>A0A3P9BJ56_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein FRG1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549320.1">
        <property type="nucleotide sequence ID" value="XM_004549263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ56"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009974"/>
    <dbReference type="Ensembl" id="ENSMZET00005010341.1">
        <property type="protein sequence ID" value="ENSMZEP00005009974.1"/>
        <property type="gene ID" value="ENSMZEG00005007549.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476710"/>
    <dbReference type="KEGG" id="mze:101476710"/>
    <dbReference type="CTD" id="2483"/>
    <dbReference type="GeneTree" id="ENSGT00390000004552"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23338">
        <property type="entry name" value="beta-trefoil_FSCN_FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000031">
        <property type="entry name" value="FRG1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="255" mass="28578" checksum="BCA177566B3904A0" modified="2019-02-13" version="1">MAEYAHVKSTKLVLKGHNKGKKKKNKDKKRKATDEEERLDIVGGWWSVSSFGEITGTVAIEMQNKSYIHALDTGLFTLGSPHRDDEGPDPPEQFTAIKLSDTRIALKSGYGKYLGISSEGVVMGRSDAIGSREQWEPVFQDGKIAFLAANSCFISYSDNGDIVAKSKTAGDGEMVKIRTCAEREVKRKDDIADEDRGNVKSCEINYVKKFQSFQDRRLRVNEGDATVLKKARTDGKFHEALLDRRSKMKADRYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJG5</accession>
    <name>A0A3P9BJG5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJG5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010057"/>
    <dbReference type="Ensembl" id="ENSMZET00005010423.1">
        <property type="protein sequence ID" value="ENSMZEP00005010057.1"/>
        <property type="gene ID" value="ENSMZEG00005007613.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286985"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17404">
        <property type="entry name" value="MFS_SLCO5_OATP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000010">
        <property type="entry name" value="Solute carrier organic anion transporter family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF142">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="147"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="568"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="810"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="891" mass="96964" checksum="B7B01FEE10CD1EA7" modified="2019-02-13" version="1">MMADHEEAELSESLQKEDGFSSEVEDPGTNFKSKSLPVLSEAAPQEKTLLASSVRMSITAEESTEFIQNPPNTESFQAESPTRANYPPKPGKSALNRPASYMENTEIRRSKHMARRKPPGFFAARLAQIRLPSRKHLGVILQDSRCFLFCMCYLTFIQSLMVSGYLSSVITTIEKRYSLRSSESGLLVSCFDIGSLLVVVFISYFGGRGQRPRWLAVGGIFIAVGAALFSLPHFISPPYQIQEVNSSSANEGLCMNSNASSRDRVDITSCPRDQEGNEHNLYVALFVIAQILVGMGSTPIYTLGPTYLDDNVKKENASLYLAIMYVMGALGPAAGYLLGGVLIGFYVDPKTVVNIDQSDPRFIGNWWSGFLLCAIAMLLVIFPMFTFPKKLPPRHKKKKRRKKLSLDDLSSDDDVLKEKSNNKTQTVTSSMGFGKDIKDLPKAAVRILSNVTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPTLTMTQRNLTGGCNVNCGCKIHEYAPVCGSDGITYFNPCLAGCGSVANDSTGIRNYSDCACVQSRQVITPSTGSQGSNQLQLVIVKTYLNENGYAVSGKCDRTCNTLIPFLIFLFIVTLITACAQPSAIIVTLRSVAEQERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQDCGVHGSCWEYDVTSLRFVYFGLAASLKFLGFFFIFLTWYSIKYKEERVERWLKRHLSPVDTVGSLVCHPGGHKGHARTRSCPVNIPRTDPNALPANAPPRAGTLNRGVSTQSCPGQELKAITPPPAAAAAPSPAAAPSPAPAQSLEHVSVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BMY5</accession>
    <name>A0A3P9BMY5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rasd family member 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560741.1">
        <property type="nucleotide sequence ID" value="XM_004560684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BMY5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011297"/>
    <dbReference type="Ensembl" id="ENSMZET00005011691.1">
        <property type="protein sequence ID" value="ENSMZEP00005011297.1"/>
        <property type="gene ID" value="ENSMZEG00005008494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481289"/>
    <dbReference type="KEGG" id="mze:101481289"/>
    <dbReference type="CTD" id="553052"/>
    <dbReference type="GeneTree" id="ENSGT00940000163566"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04147">
        <property type="entry name" value="Ras_dva"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="208" mass="23644" checksum="AEB482F39B7C9D32" modified="2019-02-13" version="1">MSIEVKEKTEVRLVFLGAGGVGKTALIQRFLKDTFEPKHRRTVEELHRKEYEVGGVKVTINIMDTSGSYSFPAMRRLSIQNSDAFALVYAVDDPDSLEAVKSLRDEILDIKEDKYTPIVVIGNKIDRNNERQVSSEDVESTVELDWNHSFLESSAKDNINVLEAFRELLQQANLPSRLSPALCRRRETFPKDSNKRPPMNKTNSCLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQH4</accession>
    <name>A0A3P9BQH4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein O-mannose kinase</fullName>
            <ecNumber evidence="2">2.7.1.183</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein kinase-like protein SgK196</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sugen kinase 196</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-O-[beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-Man]-L-Thr-[protein] + ATP = 3-O-[beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52616"/>
            <dbReference type="Rhea" id="RHEA-COMP:13308"/>
            <dbReference type="Rhea" id="RHEA-COMP:13309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136709"/>
            <dbReference type="ChEBI" id="CHEBI:136710"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.183"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.183" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004564748.1">
        <property type="nucleotide sequence ID" value="XM_004564691.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQH4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011871"/>
    <dbReference type="Ensembl" id="ENSMZET00005012277.1">
        <property type="protein sequence ID" value="ENSMZEP00005011871.1"/>
        <property type="gene ID" value="ENSMZEG00005008896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481202"/>
    <dbReference type="KEGG" id="mze:101481202"/>
    <dbReference type="CTD" id="84197"/>
    <dbReference type="GeneTree" id="ENSGT00390000004945"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019200">
        <property type="term" value="F:carbohydrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036268">
        <property type="term" value="P:swimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000464">
        <property type="entry name" value="Protein O-mannose kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039318">
        <property type="entry name" value="POMK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22618">
        <property type="entry name" value="PROTEIN O-MANNOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22618:SF2">
        <property type="entry name" value="PROTEIN O-MANNOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="81"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="350" mass="40205" checksum="7B81C7ED1855DDF6" modified="2019-02-13" version="1">MQGTVGQRSRTTVAYIVPVVGICAAAFLLTNIFIYLYLDSVYQPGLQQVSPLVGCVPQHFKMPTMKDCTAWLQCLQINAEVHELKLIDQGAVKKVYLAEWRGQKVALSRLSSLNYLEDFLHGLSMLQALQSPQVVQLVGFCLEEHIILTEHHPFGSLLNLDDVLEKKHYQQHNNWEMRLRLAIDYVTILHYLHNSPVGRRVMCDSNSLEKTLSQFLLTNDFHLVVNDLDALPEVDMSRNLSVKCGHRELTGDFVAPEQLWPFRNNRKPFSDNLMPEYDEKTDIWKIPDVTWFLMGKVPGGDLVHFHLFQIHEKCKKKDPTDRPSAFDVLKVYKSVYSSMVRDSAGFRDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRA8</accession>
    <name>A0A3P9BRA8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SNF2 related chromatin remodeling ATPase 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004549338.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRA8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012485"/>
    <dbReference type="Ensembl" id="ENSMZET00005012924.1">
        <property type="protein sequence ID" value="ENSMZEP00005012485.1"/>
        <property type="gene ID" value="ENSMZEG00005009369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471172"/>
    <dbReference type="KEGG" id="mze:101471172"/>
    <dbReference type="CTD" id="8467"/>
    <dbReference type="GeneTree" id="ENSGT00940000157297"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003231">
        <property type="term" value="P:cardiac ventricle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034117">
        <property type="term" value="P:erythrocyte aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000049">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.5.1190:FF:000002">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.10810:FF:000101">
        <property type="entry name" value="SWI/SNF-related, matrix-associated, actin-dependent regulator of"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="ISWI_HAND-dom"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SANT/Myb"/>
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    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
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        <property type="entry name" value="SLIDE"/>
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        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF54">
        <property type="entry name" value="SWI_SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="175"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="470"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="823"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1036" mass="120375" checksum="C7C5E085C3B3E92A" modified="2019-02-13" version="1">MSESANCVEQREEQAEVEDAGGAEEKSDSSDAGKESSSDAGADGQDASSSSSSSKTKDSTPGYEEKVQTDRTNRFEYLLKQTELFAHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSAGDNRHRRTEQEEDEELLNESTKTTNVCTRFDESPSYVKTGKMRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTIALLGYMKHYRNIPGPHMVLVPKSTLYNWMNEFKRWVPSLRAVCLIGDRDERTALIRDVLLPGEWDVCVTSYEMLIIEKAVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSSEDFDSWFDTNNCLGDQKLVERLHTVLRPFLLRRIKADVEKTLLPKKEIKIYVGLSKMQREWYTKILMKDIDILNSAGKMDKMRLLNVLMQLRKCCNHPYLFDGAEPGPPYTTDIHLAVNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRMLDILEDYCMWRNYGYCRLDGQTPHEERQISINVFNEPNSSKFIFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQQKQVRVFRFITENTVEERIVERAEMKLRLDSIVIQQGRLVDPSANKLGKDEMLSIIRHGATHVFASKESEITDDDIDAILERGERKTMEMKERMSSLGESSLRNFTMDTENTSVYTFEGEDYREKKKVITNWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPRNPDIPNSAQVQKEEQAKIDEAEALTEEELEEKETLLQQGFTIWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVMEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDSKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKESVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEREKAEKKKRGPKTGSAQKRKSEGTPDGRGRRKKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BS95</accession>
    <name>A0A3P9BS95_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSMZEP00005012800.1"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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    </dbReference>
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        <property type="entry name" value="Integrase_cat-core"/>
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        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF8">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rve"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="336" mass="38625" checksum="2447FA5BCBCB8EFF" modified="2019-02-13" version="1">QKQPLKLHQIPDLPWSITATDLFEWDNRHYLVLVDSYSGWFEIDKLENLTSASVINKLKHHFSVHGIPQKLYSDNGTQFISQTFREFATHWEFIHVTSSPEFPQSNGLSERAVRSAKRLLETSKRDGTDFYLNLLHLRNTPRDNILGSPAQRLLSRRTRSTLPVCKKLLTPTAKVTTTIKTQLTKKRKTQKQHYDKSSKLLSPLTPNEVVRLQTQRGHDKIGVVSKVCAEPRSYVVESGGKEYRRNRQHLLPVSEPQPEKLATTQDELDSSRRADETKPNKTQTNKHETVQLNPPQHGTKQSEQVITPTKCQVRSDDNLYRTRSGRVSKPNSKYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSK4</accession>
    <name>A0A3P9BSK4_9CICH</name>
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        <submittedName>
            <fullName evidence="4">G protein-regulated inducer of neurite outgrowth 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in neurite outgrowth.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSK4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012902"/>
    <dbReference type="Ensembl" id="ENSMZET00005013348.1">
        <property type="protein sequence ID" value="ENSMZEP00005012902.1"/>
        <property type="gene ID" value="ENSMZEG00005009696.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00570000079168"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026646">
        <property type="entry name" value="GPRIN2-like/GPRIN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032745">
        <property type="entry name" value="GRIN_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15718:SF6">
        <property type="entry name" value="G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15718">
        <property type="entry name" value="G PROTEIN-REGULATED INDUCER OF NEURITE OUTGROWTH C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15235">
        <property type="entry name" value="GRIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G protein-regulated inducer of neurite outgrowth C-terminal" evidence="3">
        <location>
            <begin position="285"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="415" mass="44995" checksum="C7315EC1999EAB95" modified="2019-02-13" version="1">MGTNPKRTVTVQMVPQLAGVDTLGNKESNANWAKEPNLKVSQVCPKPTLRSPDKQDNLSLTTANAAPRTEKTGCKGGEPVTTVSDKSAPGNGNQIKSEQVSGGDHQTPNLSVTGREVGEAGADQRDSNANMKTLSPTSETGTYKASSLSPVAASGADTNSSEYKVKNPVAPEEKQVRLTPSVETTAREKSNERLSPNDKKRNDSDVRSTASEVQDNKETISNPQSRDMAIPQKSKETGHMQGCSSTSVSLQDPSKPKKSMETPLSSAKAPSENVSAKEKSKEAGSKAQSKETNSGKKKVEPERSDKEDDQSRKQKGKSIHDVVWDEQGMTWEVYGASVDPESLGFAIQSHLQSKIKEQERKLMVQTSLRKSISGADSPRHGSKNKRRQQNIFRSMLQNVRRPNCCVRPPPSSVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BT63</accession>
    <name>A0A3P9BT63_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Potassium inwardly rectifying channel subfamily J member 15</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BT63"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013079"/>
    <dbReference type="Ensembl" id="ENSMZET00005013528.1">
        <property type="protein sequence ID" value="ENSMZEP00005013079.1"/>
        <property type="gene ID" value="ENSMZEG00005009827.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282491"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000036">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000002">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF20">
        <property type="entry name" value="ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 15" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="18">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="19">
        <location>
            <begin position="177"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="14">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="357" mass="40707" checksum="82301E03ED076C6D" modified="2019-02-13" version="1">MSFREVLRAVNLGMCSIMAKGNKDFQRRIVSKDGHNMVRIDNVEGMVKLYLHDIWTTVVDMKWRYKLTLFASTFVMTWFIFGVIFYFIGMGNGDFEPDLNSTHTPCLMNVETLTGAFLFSLESQTTIGYGFRYISEECPLAIFTLVAQLVITGLAEIFVTGAFLAKLARPKKRAETIKFSQVAVICKHQGKLCLMVRVANMRKSLLIQCQLTGKLLQPYATEEGEKTQVHQSSVDFNMYSGGECPFLILPLTFYHVLDQHSPLAGLTAENLETRRFELLITLNATMESTAATCQRRTSYIPDEILWGYEFKPVLYSTPSGRFVADFNFFDKVQKSSDPDIHSDSSEKLKLEREFREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BU14</accession>
    <name>A0A3P9BU14_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DIS3-like exonuclease 2</fullName>
            <ecNumber evidence="12">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dis3l2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.</text>
    </comment>
    <comment type="function">
        <text evidence="12">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the RNR ribonuclease family. DIS3L2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_004567269.2">
        <property type="nucleotide sequence ID" value="XM_004567212.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BU14"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013379"/>
    <dbReference type="Ensembl" id="ENSMZET00005013833.1">
        <property type="protein sequence ID" value="ENSMZEP00005013379.1"/>
        <property type="gene ID" value="ENSMZEG00005010059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472886"/>
    <dbReference type="KEGG" id="mze:101472886"/>
    <dbReference type="CTD" id="129563"/>
    <dbReference type="GeneTree" id="ENSGT00530000063106"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010587">
        <property type="term" value="P:miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990074">
        <property type="term" value="P:polyuridylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048793">
        <property type="term" value="P:pronephros development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000177">
        <property type="entry name" value="DIS3-like exonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000003">
        <property type="entry name" value="DIS3-like exonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000003">
        <property type="entry name" value="DIS3-like exonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03045">
        <property type="entry name" value="DIS3L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028591">
        <property type="entry name" value="DIS3L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <position position="559"/>
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        <ligand>
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        <location>
            <position position="568"/>
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        <ligand>
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            <dbReference type="Ensembl" id="ENSMZEP00005013379.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="1042" mass="117265" checksum="6C65D584BFB39429" modified="2019-02-13" version="1">MDSPRKAKKANVNREPKHSQNQSSRPPQKDAYARLLSQHRSSKFSLYLEQYAKDSSSQREDNGPSPQLKAQSDRVSIPARQRDQVFNDFSDSSDFSPSSVKSKGGESSLSLYMEKLNTRNVQQDCERRQGVFDGQRRGQRRDTATSHDGDVESGEELGSLKPNDAKKHQKQQRKNKDSNRDVVSKEADQPGGRLQSPKKSKKKNLPKHPEDEKIREGTSKCGVDVQMLSPKPPHGRDKNIKQPRASNANSPADKGKNKGGRGSKKQVFDAYMTSEEVSHGLKRGELIQGQLRINPKKYNEAFIPSPDDTRDIFLDGIVARNRALNGDIVVVQVLPREQWKVVRSDTDCEGVSESDTPTVQTAAKKTKSTPSSAVSVEEQCSDRDEQNNKYQNISGERLGEPSTPRSNGEILQKTAKVVYIVEKKHSRAATGFLKHLPDKPFALFSPVDHRVPRINVPLADCPEDFSSRPGDYKNTLFICRITDWAADSNFAEGRLAKSLGQAGEIEPETEGILIEYEVDFSEFSDEVLDCLPKNLPWTIPPEEMRKRRDLRNECIFTIDPATARDLDDALSCKQLPDGNFEVGVHIADVSYFVEEGNSLDVIASQRATSVYLVQKVIPMLPRLLCEELCSLNPLVDRLTFSVIWTLTPEGKILNEWFGRSIIRSCVKLSYDHAQSMIEAPEKMFSAEELPPVDPMHPIDEVHQAVLNLHTIAKNLRAQRFLGGALRLDQLKLSFTLDKETMMPQGCYIYQYRDSNKLVEEFMLLANIATANHIYRKFPELALLRRHPPPKAKMMDELQELCDQLGIKIDLTSAGLLHKSLNTAFGDDEYTSARKEVLTHMCSRPMQMALYFCTGVVKEEQNFKHYALNVPLYTHFTSPIRRYADIIVHRLLASSLKCGPRISLSTAEVEKQASHCNDKKALSKKVQELSSELFFGVFVKESGPLDSEAMVMGVLDQSFDVLVLRYGVQKRIYCKSITGLDAFRHRKVGKKSELTLLWTAESPEDPPVEQVISVFTLVEVQLKSDDAPLKYSAVLKRPEDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVA7</accession>
    <name>A0A3P9BVA7_9CICH</name>
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        <submittedName>
            <fullName evidence="5">Immunoglobulin heavy variable 10-1</fullName>
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        <name type="common">zebra mbuna</name>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Immunoglobulin heavy variable 11-1"/>
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        <property type="entry name" value="Immunoglobulins"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="110" mass="12360" checksum="BD44D0F0DF45AB5C" modified="2019-02-13" version="1">QTLTQSEPVVKKPGESHRLTCTTSGLSFSSNWMAWIRQAPGKGLEWIATDTNGGSNYYSQSVQGRFTASRDNSREQLYLQMNSLKTEDSAVYYCILGYLDQNTKFCSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVH6</accession>
    <name>A0A3P9BVH6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Nuclear transport factor 2</fullName>
            <shortName evidence="5">NTF-2</shortName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004564664.1">
        <property type="nucleotide sequence ID" value="XM_004564607.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004564665.1">
        <property type="nucleotide sequence ID" value="XM_004564608.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVH6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013641"/>
    <dbReference type="Ensembl" id="ENSMZET00005014105.1">
        <property type="protein sequence ID" value="ENSMZEP00005013641.1"/>
        <property type="gene ID" value="ENSMZEG00005010269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484922"/>
    <dbReference type="KEGG" id="mze:101484922"/>
    <dbReference type="CTD" id="10204"/>
    <dbReference type="GeneTree" id="ENSGT00510000047030"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000007">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="127" mass="14483" checksum="757590C5DE746DF3" modified="2019-02-13" version="1">MVDQPLWEQIGSSFVQHYYQMFDSDRSQLGSIYIDASCLTWEGQQYQGKRAIVEKLASLPFQKIAHSITAQDHQPTPDSCILSMVVGQLKADEDPIMGFHQSFILKNINDAWVCTNDMFRLAIHNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVP5</accession>
    <name>A0A3P9BVP5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probably involved with other LSm subunits in the general process of degradation of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544267.1">
        <property type="nucleotide sequence ID" value="XM_004544210.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVP5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013706"/>
    <dbReference type="Ensembl" id="ENSMZET00005014175.1">
        <property type="protein sequence ID" value="ENSMZEP00005013706.1"/>
        <property type="gene ID" value="ENSMZEG00005010321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467747"/>
    <dbReference type="KEGG" id="mze:101467747"/>
    <dbReference type="CTD" id="27257"/>
    <dbReference type="GeneTree" id="ENSGT00730000111133"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000021">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="133" mass="15231" checksum="488DDE182699D3B7" modified="2019-02-13" version="1">MNYVPGTASLIDDIDKKHLVLLRDGRTLIGYLRSIDQFANLVFHQTVERIHVGKKFGDIPRGIFIVRGENVVLLGEIDMDKPCDTVLQQVSIEEILEEQRLQQQAKQETEKVKMQVLKDRGLSIPKADNLDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXB6</accession>
    <name>A0A3P9BXB6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Si:ch211-215k15.4</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012777015.1">
        <property type="nucleotide sequence ID" value="XM_012921561.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXB6"/>
    <dbReference type="Ensembl" id="ENSMZET00005015022.1">
        <property type="protein sequence ID" value="ENSMZEP00005014539.1"/>
        <property type="gene ID" value="ENSMZEG00005010943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481859"/>
    <dbReference type="KEGG" id="mze:101481859"/>
    <dbReference type="GeneTree" id="ENSGT01060000248575"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF8">
        <property type="entry name" value="SI:CH211-215K15.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017928600" evidence="10">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="11">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="11">
        <location>
            <begin position="169"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="311" mass="34227" checksum="1327D1EEB4B9FE37" modified="2019-02-13" version="1">MMKLNAFLLLLLLGISSVSTYQNVALRGKATQSTRLTDNPVSAAHNAIDGNRNSEFSVGSCTHTNEQTNPWWRVDLLQSYIITSVTIFNRGDCCQHRLSGLEIHIGNSLNNEGLENPKVGTISEGRTGESKLTFTNRVEGRYVTLTLPGSGRILTLCEVEVYGYPAPTDENLALQGKATQSSRYSFGIAYNAIDGNRNSKWEEASCTLTKKSMSPWWRLDLLKTHKVFSVSIVNQDSQPERLDGAEIRIGESLENDGNNNPRCAVITGIAGGAVAVFKCNGTEGRYINIVIPKRNEFLSLCEVEVYGSRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY11</accession>
    <name>A0A3P9BY11_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LUC7-like (S. cerevisiae)</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562482.1">
        <property type="nucleotide sequence ID" value="XM_004562425.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BY11"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014789"/>
    <dbReference type="Ensembl" id="ENSMZET00005015277.1">
        <property type="protein sequence ID" value="ENSMZEP00005014789.1"/>
        <property type="gene ID" value="ENSMZEG00005011133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479367"/>
    <dbReference type="KEGG" id="mze:101479367"/>
    <dbReference type="CTD" id="55692"/>
    <dbReference type="GeneTree" id="ENSGT00950000183213"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="369" mass="43863" checksum="5ECE9CD8E04F365C" modified="2019-02-13" version="1">MSAQAQMRALLDQLMGTARDGDETRQRVKFTDERVCKSHLLNCCPHDILSGTRMDLGECTKIHDLALRADYEIASKERDLFFELDAVDHLESFIVDCDRRTELAKKRLAETQEEISAEVAAKAEKVHELNEEIGKLLAKAEQLGAEGNVDEAQKVLQEVEKVRTKKKDAEEEYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLKKTVVEKQEKRNQERLKRREEREKEERMRRRTRSRSREHRRSRSRDRRRRRSRSSSRDRRRSRSRSRERRRRHRSRSRSRSRGHRHSHEQSSRHKSSRDRERSSRDRDRSSRDRSRERDRRDGMNGRSDSRRADDRDVGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZ98</accession>
    <name>A0A3P9BZ98_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
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                <person name="Rakotomanga M."/>
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                <person name="Sharpe T."/>
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                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
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                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSMZEP00005015305.1"/>
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            <begin position="12"/>
            <end position="30"/>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16329" checksum="207167129C02204F" modified="2019-02-13" version="1">MHFNFSIFQHLLSYSLLSFFVMFSLIFFTGSSLSDQVHQNPADMYKNLEETAEITCSHSIDTYNQILWYKQTKTGQMQFLGYMLGTSSSVEPPSPPHHTHSHNLLTDSFALYTPLPLVCKPLLLYGQSFLLWVYKLLHWSL</sequence>
</entry>
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    <accession>A0A3P9C052</accession>
    <name>A0A3P9C052_9CICH</name>
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        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4. Interacts with LASS2. Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Clathrin-coated vesicle membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Vacuole membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004571346.1"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005015613"/>
    <dbReference type="Ensembl" id="ENSMZET00005016114.1">
        <property type="protein sequence ID" value="ENSMZEP00005015613.1"/>
        <property type="gene ID" value="ENSMZEG00005011714.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477261"/>
    <dbReference type="KEGG" id="mze:101477261"/>
    <dbReference type="CTD" id="325402"/>
    <dbReference type="GeneTree" id="ENSGT00550000074873"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
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        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
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    <dbReference type="GO" id="GO:0030672">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
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    </dbReference>
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        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
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        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
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        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
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        <property type="entry name" value="F/V-ATP_Csub_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="155" mass="15662" checksum="E16F98147047A333" modified="2019-02-13" version="1">MSSSEGPEYAPFFSAMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPELIMKSIIPVVMAGIIAIYGLVVAVLIANNTAEKQSLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0V7</accession>
    <name>A0A3P9C0V7_9CICH</name>
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        <submittedName>
            <fullName evidence="4">CAP-Gly domain containing linker protein 2</fullName>
        </submittedName>
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    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014269112.2">
        <property type="nucleotide sequence ID" value="XM_014413626.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0V7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015506"/>
    <dbReference type="Ensembl" id="ENSMZET00005016004.1">
        <property type="protein sequence ID" value="ENSMZEP00005015506.1"/>
        <property type="gene ID" value="ENSMZEG00005011621.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159426"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000001">
        <property type="entry name" value="Putative CAP-Gly domain-containing linker protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF10">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="529"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112802" checksum="D61D7741C27C4C67" modified="2019-02-13" version="1">MNMLKSSGLKIPGRGAKHSSPVGRTSAGGTSSPVAPKDSAALKPTTPTKISEEGDDVLGDYTVGEQVWVNGVKPGVIAYLGETQFAPGQWAGVILNDLVGKNDGSVGGVRYFECQPLQGIFTRPSKLTRQPVGEGSDSHSTDSTQNQTQQGGGGGSAPAGQRVVVPLREGLLNSAVKTGNESGSNMSDSGSVKKAGDKDLRVGDRVLVGGSKMGVIRYMGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCLPKFGLFAPVHKVIRIGFPSTSPAKAKKSKRVAMGVSSLAHSPSSSSISSVSSVASSVGGRPSRAGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEMAKATSHICEVEKELSALKAQHMQYVTENENGLQQVKAMLASTQKDKLELANQLEEEKRKVEDLQFRVEEESITKGDLEGRCTHEAVSLRLGKRTKQTTVEEKSRIMQLEEELSLRRAEITNLQVQLKGADASWQKVDRADAAQGSDAQPETLLLREQLVSAGREHYKESSELREKYETALAASQQEIDSLKAVVEKQNVEINEMKQKAQQATKENVEMMDTWKAKFDTLVSDHQRSLEELKATLSSSHTATEGQEQDTQELRATLESLKMEHQLEVENLKAKHKIEAAILTKEREDLCARLQEAKDQLAQGNQTWRAELEAKSGKHALEAATDKLQKAEQRLADMETLQMEQNKRAEELRERLELSEKQMTDYQALQKAQEASQEEIQKLEEKLRVTANQLQAIQAERFTSNDANVIEDNEISDEKMKLKQNIEETMEKLLKREKEVSTLTSQVEALKSQIGALEGKVRSGEKRAEALAKEKTRMEAELESMTKKSHDASGQLVSISQELLKKERSLNELRVLLLESHRHSRDMDKDLSREVHKAEWKVKEQKLQDDIKTLREKLLLLGRERSSPDHRRYSMLDPSALDSEVTRLRQRLLSTEEALRNALEHNQQVDQLVQAMRKNPEKSPVHGANSANGIHHQESHSAQDEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C162</accession>
    <name>A0A3P9C162_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein 42</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C162"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015616"/>
    <dbReference type="Ensembl" id="ENSMZET00005016117.1">
        <property type="protein sequence ID" value="ENSMZEP00005015616.1"/>
        <property type="gene ID" value="ENSMZEG00005011711.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000039706"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22110">
        <property type="entry name" value="F-box_FBXO42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052821">
        <property type="entry name" value="F-box_only_SRC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46432">
        <property type="entry name" value="F-BOX ONLY PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46432:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13415">
        <property type="entry name" value="Beta-prop_FBX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="731" mass="78410" checksum="9ACD459124733F91" modified="2019-02-13" version="1">MSQQTIMSRSPDNEDGGGHVAMDTEDEGSEPAGITEEVEAKMGSSCQEGNMDSGAKGEGRTMVELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAYQCYHGFLRAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDSNQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVMHKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSSVIGNNMIVFGGSLGARQMSNEVWVLDLEQWSWSKPPISGPSPHPRGGQSQIVIDDQTLLILGGCGGPNALLKDAWLLHMDALPWRWQQLQVENEDHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPAPLGPEPPSLRSQSPVRSGAAGVVLGAVEEAPCVNGRWGTLRPRPSARGGARDGSPSSSQQPSPSQGPESPPLPPLINGSSPSPRTSPAQAASPPSRPHLPSSTDYGWESPPSAAHHPEVPSTNGLHTPPSGSPCTPPGAVSPAALRRGLEAVKNKSSSSVPSSSSSSSLQTQGPSPGGGAGPPGTPPSSSSSPPQVAGADGHAIPPIARRLGHHPPQSLNVGKPLYQSLNCKPMQMYVLDVSRAKSAGVVSWRVYGNGTPPAVTGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKRRTTRKFLFFVSSSSELLEYVWKSGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2K5</accession>
    <name>A0A3P9C2K5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CITED family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564465.2">
        <property type="nucleotide sequence ID" value="XM_004564408.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2K5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016478"/>
    <dbReference type="Ensembl" id="ENSMZET00005016999.1">
        <property type="protein sequence ID" value="ENSMZEP00005016478.1"/>
        <property type="gene ID" value="ENSMZEG00005012368.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101480436"/>
    <dbReference type="GeneTree" id="ENSGT00530000063624"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2200:FF:000001">
        <property type="entry name" value="Cbp/p300-interacting transactivator 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007576">
        <property type="entry name" value="CITED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17045:SF5">
        <property type="entry name" value="CBP_P300-INTERACTING TRANSACTIVATOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17045">
        <property type="entry name" value="MELANOCYTE SPECIFIC GENE RELATED CITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04487">
        <property type="entry name" value="CITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="232" mass="26040" checksum="2C12A60C4047798F" modified="2019-02-13" version="1">MAEHMMMPMNHGFRMGMNGPPQHNCQRSLPNGQVMHYGRNPQSNMEAAMRQRPGMVGPGGMVPVNGAPMANHHHHQMMSGNMMYNGQCPQQQQQHHHLHSQQQQQQQQQGGHPQQYLPGNLTSQQLMASMHLQKLNTQYHGHPLSSTNGHHLPNGPQYRMGPAQLSSMQHISGPLGLNGMDMDLIDEEVLTSLVLEFGLDRIQELPELFLGQNEFDFISDFVCKQQPSTVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2Z6</accession>
    <name>A0A3P9C2Z6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004558533.1">
        <property type="nucleotide sequence ID" value="XM_004558476.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2Z6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016623"/>
    <dbReference type="Ensembl" id="ENSMZET00005017156.1">
        <property type="protein sequence ID" value="ENSMZEP00005016623.1"/>
        <property type="gene ID" value="ENSMZEG00005012483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479461"/>
    <dbReference type="KEGG" id="mze:101479461"/>
    <dbReference type="CTD" id="2962"/>
    <dbReference type="GeneTree" id="ENSGT00440000038032"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00240">
        <property type="entry name" value="TFIIFa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000290">
        <property type="entry name" value="General transcription factor IIF subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="532" mass="59274" checksum="EB24757B14A9ACB3" modified="2019-02-13" version="1">MTSLGSSSSTSTTEYIVRVPKNTSKKYNIMAFNAGDRVNCSTWTQARMERDMSARKIYGEEETPEGAAGSEFGKKQREEARRKKFGIVTREFKVEDQPWILKVNGKAGKRFKGIKKGGVTENASYYIFTQCPDGAFEAFPVHGWYNFTPQAKHRTLTAEEAEEEWGRRNKVVNHFSIMLQRRLREQERGEEDEDEGEKSGKKKKKGGGRGGDLRIHDLEDELEMSSDDSDSSMGDDGESKPKVKKDAGKGKAKRKKQKSKDNEALEDSDDGDYEGLEVDYMSDESSSEEEPEKGKPVKAEEHPKGIDEESESEEESEEEKQNDEEAKEEEEEEEGKKTPVQMEKKKKKDSSGESDSSDDSDIEGETASALFMAKKRTPPKRAGGRGSAGSSRTGSRPGTPSLDSASTSNTLRAAASKLEQGKRQGPSIDSPAAKKLKMEPSTQSPVPSGKSTPQPQSGKSTPSSSDVQLTEEAVRRYLIRKPMTTKDLLKKFQTKRTGLSSEQTVNVLAQILKRLNPERKNINDKMHFYLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3G7</accession>
    <name>A0A3P9C3G7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uveal autoantigen with coiled-coil domains and ankyrin repeats</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005016672"/>
    <dbReference type="Ensembl" id="ENSMZET00005017205.1">
        <property type="protein sequence ID" value="ENSMZEP00005016672.1"/>
        <property type="gene ID" value="ENSMZEG00005012517.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157475"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042420">
        <property type="entry name" value="RAI14/UACA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24129">
        <property type="entry name" value="ANKYCORBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24129:SF1">
        <property type="entry name" value="UVEAL AUTOANTIGEN WITH COILED-COIL DOMAINS AND ANKYRIN REPEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1219"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="274"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="409"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="668"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="822"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1283"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1377" mass="156722" checksum="F85A02B0C5FB73DF" modified="2019-02-13" version="1">MKSLKYRLKKHEVTITNTDWNKYDDRLMKAVERGEVDKVSAVLNKKGIIPTKLDVEGRSAFHLAATRGHLEVLNLILGHNVDVTASDAAGKSALHLASRNGHSLCVQKLLQHNSPVGNVDLQGRTALHDAVMAGCASSVKLLCDSGAAVNATDFDGRTPLILATQMCHPRICQLLLERGADITVRDKQNKTALILGCEFGCKDAVEVLLKSGADVKTVDGLGHDAHHYARFNKDQELITMVKSYIDKANRDKEAAKIEQWKRQHSVERTEAAEINRKDQIIHDLERQNETLQEGLRKYYQEQKALLDKVNMLQQQLTQEKMAAEDSQKEKEQLKMLLSTKEKDEGARGQETVKVQLRSTLGEYSGQSVIKGKENVFVKGHSLDSDQMLRNPPLSRSLSRPLEKGLPGELDALRNELEAVKKRQQAAEEETTRLQSALSRKTRECQELLQSRDTIQKQADQQVQELEDALGDVQKRMLDSECKVKQLQAHVVAVKEHLGGQAAEELRTQLQDVKAKYEGASAEVGRVRNRLKQSEKALEEYKSSESQLAADTERLNHDVQNLNTERDVLRETLLEMETQLKEAQTKHGNTVPAEKFDNMKNLLTNAVDEKERQLAELREDYDRVLEEVAELHRKLDSPSSQGGPRPLSAEEQQVWAALEDENATLKKTLVEVTAKSQALIHEVEKSEDEKDMLQEQLDELNSRIEVDFIPIQNHEEVRRNMVTALEDLEDKLVEAGERCGRAEAQVQQLQTERGALQKNISSLSSTSEKQQSEMDTMRCQNADLIKKVELLQKRCEDRDKECVQLTTQSQTLKESLEGQYVPRQQHEQVKMELSSTLESVKAEMLKLETREKESGEELKNVKEGNEKLKEKLEKVLLEMKNDYISVKDHRAITDKLNAAVVEAENRANEASAMHALAQDETVKLTHELEAQKKELDTIQEAIQSKFVPLTTAEEKETSYSTQVKELTAKLLEMEEKYDKEKTAREGNRQEEKKLKVEVESVQRRLDVALVSSEKHKENEEEFKAKCEELTQKLVNLEQQLDEVTLQKAELQEQNALCNAQIQNLQERLKSELTRISTYDTELKALNDALQQAQADCKKAREAQQAEAQKVCAFQKEVQELHREQESLLQHAEAKEALEAEVAKLHLALREEEENNAQRAEDVSALQSELLQATQALEEIRCKEDQMNELKKEKQQLEEEAASLNNKLLSLVEEREKVHQEATKAREGESRARTEMEAVQEKGRTIEREIRELKERYDESLTTICDLQKRIQTSAEQTEAKDKKITELLTDVERLKQALNSLSQLTYTSNTPKRQTQPIDTLQAQIKSLQQQLADAERQHREVVSIYRTHLLSAAQGHMDEDVQAALLQIIRMRQEFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3J0</accession>
    <name>A0A3P9C3J0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3J0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016466"/>
    <dbReference type="Ensembl" id="ENSMZET00005016987.1">
        <property type="protein sequence ID" value="ENSMZEP00005016466.1"/>
        <property type="gene ID" value="ENSMZEG00005012336.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159607"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF158">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="239"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="426" mass="47645" checksum="2A8B1CAFAB0121A9" modified="2019-02-13" version="1">IMSKVEKQKKHFPAQASKRKTNKKNGILKKNERHWFYSAPANKEQEKPTAPQTAPPKDSQQFSANWKALQEVSECNSLSSMHVLSHTLNGFSPKNVQENTSKIISKNNAAPSQRDTENKSDHKTVPKSFVSGKTGVNSKVSNVSKTKHVIAPERERDSGKPNSLQAAKKKKLESEETKPTEEDLWFDDVDPDDIEATMGAEAAEIMRKKQGKAKGTDGASANDTEKSLVKENAFEGLTKAVAIDCEMVGVGPDGEDSILARVSIVNQFGKCIYDKYVKPTEKVTDYRTAVSGIRPEDIKDGADVQIVQREVANILEGRVVVGHAIHNDLKILLLDHPKKKIRDTQKYKPFKTIVKSGRPSLKLLCRKILDVKVQEGEHSSVQDAQATMRLYTMVKKQWEAEIKVSRKNKFLDKRSERKQSCATKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3U1</accession>
    <name>A0A3P9C3U1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012778550.2">
        <property type="nucleotide sequence ID" value="XM_012923096.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3U1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016787"/>
    <dbReference type="Ensembl" id="ENSMZET00005017323.1">
        <property type="protein sequence ID" value="ENSMZEP00005016787.1"/>
        <property type="gene ID" value="ENSMZEG00005012618.1"/>
    </dbReference>
    <dbReference type="CTD" id="26273"/>
    <dbReference type="GeneTree" id="ENSGT00940000153571"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22084">
        <property type="entry name" value="F-box_FBXO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052121">
        <property type="entry name" value="F-box_SCF_Substrate_Recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46550:SF1">
        <property type="entry name" value="F-BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="ApaG" evidence="4">
        <location>
            <begin position="275"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="458" mass="52592" checksum="A8FA4423754A6227" modified="2019-02-13" version="1">MAAAFMELRMDQLPTDPLLHILSYLDFRDLMHCSFVSRRLNELSKHNPLWKSQCCKHWLLTDDDRLQSGVSWFCLFKQYYTDLGRYIQYYAVLKRAWEQLKSFLQQRCPRMIASLKEGTTEVELNDIEAQIGCKLPDDYRCSYRIHNGQKLVIPGLMGSMSLSNHYRSEVLLDVETAAGGFQQRKGMRRCLPLTFCFHTGLSQYMALEPAEGRQMFESFYPCPDQTAQDPSAIDMFITGSCFLEWFTTYVHNVVTGEYPIIRDQIFRYVHDKSCVATTGDITISVSTSFLPELSSVHPPHFFFTYRIRIEMSSSASPEAACQLDSRYWKITTSDGNVEEVQGPGVVGEFPVMTPGKVHEYASCTTFSTSSEYMEGHYTFHRLASKEEVFHVAIPRFHMVCPPFREPVVRTQKALASYTPRFDDHDDDGEYCDGDGDDFDDLRGINMAALEGAWCPRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3V5</accession>
    <name>A0A3P9C3V5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterogeneous nuclear ribonucleoprotein C</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
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                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
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                <person name="Gante H.F."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
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                <person name="Mwaiko S."/>
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                <person name="Venkatesh B."/>
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                <person name="Streelman J.T."/>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN ASTER-B"/>
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            <end position="644"/>
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            <begin position="1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C5R1</accession>
    <name>A0A3P9C5R1_9CICH</name>
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        <recommendedName>
            <fullName evidence="7">FXYD domain-containing ion transport regulator</fullName>
        </recommendedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <text evidence="2 7">Belongs to the FXYD family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FXYD7"/>
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    <dbReference type="InterPro" id="IPR000272">
        <property type="entry name" value="Ion-transport_regulator_FXYD"/>
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    <dbReference type="PANTHER" id="PTHR14132:SF22">
        <property type="entry name" value="FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005948"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="96" mass="10884" checksum="C571218089C67667" modified="2019-02-13" version="1">MQCFTITTRGTRLSLLFSLLCYAAPTFRIQSNTANQHLSSSSPLHLFRVWFLFLLDYETLRTTGVILAVIMFVSGILIALSKLHRCGKSHAHSKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C630</accession>
    <name>A0A3P9C630_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C630"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017346"/>
    <dbReference type="Ensembl" id="ENSMZET00005017894.1">
        <property type="protein sequence ID" value="ENSMZEP00005017346.1"/>
        <property type="gene ID" value="ENSMZEG00005013039.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014122"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043009">
        <property type="term" value="P:chordate embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="211" mass="24379" checksum="0A7F699E6A398EAD" modified="2019-02-13" version="1">MEVFPLAVERSCNLEGDVILNLQQLKLTEAQEHNRHQLESKMALLELEMNSDLKAQLRELNITAAKEIEVGGNRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDSSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVVFEFPEFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C996</accession>
    <name>A0A3P9C996_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphofurin acidic cluster sorting protein 1/2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C996"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018848"/>
    <dbReference type="Ensembl" id="ENSMZET00005019452.1">
        <property type="protein sequence ID" value="ENSMZEP00005018848.1"/>
        <property type="gene ID" value="ENSMZEG00005014141.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183209"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF17">
        <property type="entry name" value="KRUEPPEL TARGET AT 95D, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="87" mass="10043" checksum="57356D4A249D6E78" modified="2019-02-13" version="1">MSMTVVMKEKNKKVIFLSKKAKEKEAESRSQLIEGISRLICTSKHQHTLRVSVDGVEWNDVKFFQLAAQWPTHVKHFPVGIFGYNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9G2</accession>
    <name>A0A3P9C9G2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018722"/>
    <dbReference type="Ensembl" id="ENSMZET00005019323.1">
        <property type="protein sequence ID" value="ENSMZEP00005018722.1"/>
        <property type="gene ID" value="ENSMZEG00005014051.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005019339.1">
        <property type="protein sequence ID" value="ENSMZEP00005018737.1"/>
        <property type="gene ID" value="ENSMZEG00005014051.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155466"/>
    <dbReference type="UniPathway" id="UPA00143"/>
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        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08691">
        <property type="entry name" value="C2_NEDL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000036">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000007">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000048">
        <property type="entry name" value="HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000042">
        <property type="entry name" value="MKIAA1625 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037795">
        <property type="entry name" value="C2_HECW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040524">
        <property type="entry name" value="HECW1_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032348">
        <property type="entry name" value="HECW_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF442">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18436">
        <property type="entry name" value="HECW1_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16562">
        <property type="entry name" value="HECW_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="194"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="942"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="1185"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="353"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="482"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="645"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="982"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1484" mass="164731" checksum="802CC2F692E134D7" modified="2019-02-13" version="1">MRPSLATAVLPPRTRSHNPPNLSVGGREHLSAPRRRSPHLRHTLSPENLRTLAERGGAAVDTVSVVSSPIGLPRANSDTDLVTSQSRSSLTASTLEYTLNRGQNLVISWDIKEEVDATDWIGLYHIDETSPSNVWDCKNRGVNGTQKGQIVWRLEPGPYFMEPETKICFKYYHGVSGALRATTPCITVKNPAVLVEGLAEQVGVEHPRKLISFTLTDLRATGLKKGMFFNPDPYLKMSIHPGKRSVFPVFSHHGQERRSAIIANTTNPVWHGEKYTFVALMTDILYIEVKDKFAKSRPIIKRFLGQLTIPVQRLIEKIPGVQPVSFSLCRRLPTEHVSGQLQFKVELTSTGPDGASPDSIIGVSSLNGAPGTPSDDEDLPHHLPGLVSAGPSPTGSQGSQGTGEGATAACLEKELPFIGAEGRFGDTESIAGHEMLQGSFSESLDAIEAPKGPGERPLGAASPKLRSSFPTHTRLSAMLHIDSDEDEERSGANDITPVPLSPLLMNGEPPDARGTDEDDTEGQQEPERPVGSVLEAGPVGGGAKAEDTAPEAQAAAEAVAGTDLEDVLEQDVFLEVEEVPFTEAASHDALSEGGDAPEQGRMAGEEPLSEIDSCSMATAPQTVFSSSDSCPVTLTTAVEAEEGAETAIDPGGDIDSAAPPTNQAVDGEGQGAAAEAEAPPPPPTSEEQEVEEISVRRLSLQAAGGVAEQQEGEAKPSEEAGSADSEQVTTETEGEEGAHVNGHPVRSLPSVRHDIHRYQRVDEPLPPNWEARIDSHGRIFFVDHVNRTTTWQRPTGPPAPQGLTRSNSIQQMEQLNRRYQSIRRTITNSDRSEESSVDLVPEPESELMPHSISEYRRESGVAHSSSRSRLSLLLQSPSAKFLCSPDFFTVLHSNPSAYRMFTSNTCLKHMISKVRRDTHFFERYQHNRDLVTFLNMFSNKQLELPRGWEMKHDHTGKPFFVDHNCRSTTFIDPRLPLQSSRSTGLLAHRQHLSRQRSHSAGEVVDDSRQTNPPVLPRPSSTFSGSSRSQYHDVVPVAYNDKIVAFLRQPNIFEILQERQPELARNHSLKEKVQFIRSEGVNGLARLSSDADLVILLSLFEEEVMSYVPPLLHPGYCLSSPQSSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSKLYVSFVGEDGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALVHQYLLDAFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDNDIEDMLDLTFTVNEEVFGQITERELKPGGAGIPVSEKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEIDLADWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBD8</accession>
    <name>A0A3P9CBD8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Golgi apparatus membrane</location>
            <topology evidence="2 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBD8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019610"/>
    <dbReference type="Ensembl" id="ENSMZET00005020239.1">
        <property type="protein sequence ID" value="ENSMZEP00005019610.1"/>
        <property type="gene ID" value="ENSMZEG00005014713.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155456"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000017">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000012">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF37">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 18" id="KW-0430">Lectin</keyword>
    <keyword evidence="17 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="472"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="609" mass="70016" checksum="EFDE61C7B4A0A54D" modified="2019-02-13" version="1">MACTRRTKTLVSTCVILSGMTNIVCLLYVGWVTNYIANIYIKVPMPLPERKLEGDKRGDTLRIMERLDRLENVVNQHIHETPGKDDDGQPDTSFSDSSLFAHWGQELSPDNRRVALKQFQYYGYNAYLSDRLSLDRPIADLRPDGCRNITYPLNLPQVSIVFIFVNEALSVILRSIHSAVNRTPSHLLKEIILVDDNSNNNELKEKLHDFVSETNSQRPGFIKMVRHDKQEGLIRSRVSGWRVATAPVVALFDAHVEFSVGWAEPILQRIKEDRTRIISPSFDNIKYDTFEIEEYPLSAQGFDWELWCRYLNPPKSWWHKGNKTAPIQSPALIGCFVVDRLYFEEIGLLDEGMEVYGGENVELGIRVWQCGGSIEVLPCARIAHIERAHKPYTEDLTSHVRRNALRVAEVWMDEFKSHVYMAWNIPLEDSGIDIGDVSERKALRKRLQCKTFRWYLVNIYPDMRMYSETLAYGVLKNSLKTDLCLDQGPDNDNMPILYLCHGMTPQNVYYTSTQQLHIGLLSPTIDDDDNKCLVDVNSRPRLIECSYAAEKRMKLHWLFTQGGSIQNRKSKRCLELVASSDNEFGYQLALQKCTGQKWFITNVLFSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CC45</accession>
    <name>A0A3P9CC45_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane protein 63A</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012772096.1">
        <property type="nucleotide sequence ID" value="XM_012916642.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012772097.1">
        <property type="nucleotide sequence ID" value="XM_012916643.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CC45"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019853"/>
    <dbReference type="Ensembl" id="ENSMZET00005020497.1">
        <property type="protein sequence ID" value="ENSMZEP00005019853.1"/>
        <property type="gene ID" value="ENSMZEG00005014909.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472984"/>
    <dbReference type="KEGG" id="mze:101472984"/>
    <dbReference type="CTD" id="9725"/>
    <dbReference type="GeneTree" id="ENSGT00940000159576"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF24">
        <property type="entry name" value="CSC1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="43"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="221"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="416"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="746"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="793" mass="90266" checksum="A9EFC8838044D8D4" modified="2019-02-13" version="1">MKSLWWEQESHLPANRSDGTVCFNSTQSTVLKGLEFGGVPAVLLINFVVFVILLIIFTIIRKQFWDYGRLALVADDDGFTGSSHRRYGRKSSTGSNMEEPDYDTGFCSWLWYLFTIDDEKIKAKCGMDAVHYLSYERHLIYLLVILTVLSIGVILPVNMTGGLLNIDKQKFGETTIGNLKKGNNLLWLHTVFAVIYLILTALLLQRHVSRMKGTRREIARNTLFVCSLPKEVTAEDVKTHFVEAYPSCQVCAVTLAYNVTKLMYLDKERIRAGKNLCYYEHVLRKKGQRVFITPRMCGYLCCCVSCVKVDAIEHYHAKERLLLEEVRQEAEIAPHYPLGIAFVTLQTEAMAKLILKDFNAVKCGTMSSCCGAQRQPSSKSQSLKVNKWRVGFAPYTRNVYWENLSVQGFSWYARYVALNLFLFILLTLFTTPTIIINTMDKFNVTKPINALNSPIISQFFPTFLLWAFSALLPTIVYYSTLGEAHWSRSSEQLSMMRKLYFFLLFMVLLLPSLGLTSLAVFFQWLFDKEFLSNGTVRFECVFLPDQGAFFVNYVIAAALVGSAMELLRLPGLLLYVIRLMIARSAAERKYVKENQAYEFEYGAMYGWILCLFTVILAYSIICPVIVPFGLIYMVLKYLVDRYNLCFVYLSARLDRQVHLEAVNQALGAPIICLIWLYFFSALRMGFWAPTSLFTLVVLCITIIISLSYTCFGFFKYLSPLNYVVKDEDEDPGEGVDESTSVYLPRVLNPKSPASIPQNDDQAPQSYGSFDDTAACSFTPVDKNMEESNSDLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDW5</accession>
    <name>A0A3P9CDW5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Golgi transport 1Bb</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDW5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020086"/>
    <dbReference type="Ensembl" id="ENSMZET00005020734.1">
        <property type="protein sequence ID" value="ENSMZEP00005020086.1"/>
        <property type="gene ID" value="ENSMZEG00005014327.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014507"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF79">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN GOT1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="124" mass="13558" checksum="13749C68236CDA80" modified="2019-02-13" version="1">SFFFLMSAEIGMGLTGFGVFFLFFGMMLFFDKALLAIGNILFVSGLSFVIGLERTFRSVGGFCLAGRLLGVVLEIYGFFLLFRGFFPVAVGFIRRVPVLGSLLSLPGISAVSVTLRHFNLNKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEU6</accession>
    <name>A0A3P9CEU6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor-like 4aa</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEU6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020564"/>
    <dbReference type="Ensembl" id="ENSMZET00005021237.1">
        <property type="protein sequence ID" value="ENSMZEP00005020564.1"/>
        <property type="gene ID" value="ENSMZEG00005015431.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154546"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="68"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="122" mass="14034" checksum="01B56F7ECCEF22D9" modified="2019-02-13" version="1">MTVTFHFWDVGGQEKLRPLWKSYTRCTDGIIFVVDSVDAERMEEAKTELHKIAKSSENQGVPLLVVANKQDLRHSLGLAEIEKLGSKCATKTWPKLLYHPQQSKGLIQDWMDQCFYAVYTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGU1</accession>
    <name>A0A3P9CGU1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGU1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021081"/>
    <dbReference type="Ensembl" id="ENSMZET00005021775.1">
        <property type="protein sequence ID" value="ENSMZEP00005021081.1"/>
        <property type="gene ID" value="ENSMZEG00005015815.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154566"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF7">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="9">
        <location>
            <begin position="862"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="612"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1012" mass="114569" checksum="E7050E9F9F2A759F" modified="2019-02-13" version="1">SANMSGPGQDSEPEAKVLLIKRLYRAVVETVHKLDVIIGSKSSYREVFKPENISLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQVIKTNKKHIHSRSALECAYRTHLIAGVGFYQHLLLYIQSHYQLELQDCIDWTHVTDPLIGRKKPVSATPKEMEWAQMACHRCLVYLGDLARYQNELAGVEAEQLAERFYHQALSVMPHVGMPFNQLGTLAGSKFYNVEATYYYLRCIQSDAPFEGAYGNLKRLFDKAAKMYHQVKKQEMKKLSPSRQRSKDIKRLLVSFMYLQSLLQPKNSLMETELTSLCQSVLEDFNLVMFYLPPPTHGGAHHTPSEEEEEQQQHSDSSYPVLPDNLIFKMVVTCLMVVHSLKRGGSKQYSASIAFTLALFSHLVNHVNIRLQAELEEAESQVPPLQTDAAGEREISIEEQRKMNEEKQRQKKKYSRLSRLRRRRCARKDGHGEDESDLSEGFEINSSSVKKEPKRDALGEEGSWGSGSEEEEEGGTAFDVETDSDMNSQESRSDLEDIEDTENSEGHAREHQDDEDEDQPKEDAGERDTTDTPPTTNGPLMSSDSSISSNLQAMSSQLFQAKRCFRLAPTFSNMLLRPHASSSPSIPTPTDNLDSDSEGSQHSTESVHSEKTLLEKLEIMTNQGLIQVVKVFLDWLRTNTDIILMCAQSSQSLWNRLSVLLNLLPDGSKLLEAGELLLNAEVTELLNECERPDLVQSLLLPEDLALRHLPALGVAHRRLDFSRRNPSLSPLQECVVRVCCIRSFGHFLTSLQGNVLHFNPEAGIFTSVSQSKQDNLVQQAKAQFRMAEEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSSMSPYLVPDTAALCQHLNLIRQLAGSGCFIIIIPRTVIDGLDRLKKENAGARDGIRFLESEFRKGNRRSRVEVLKRDKLKRQDIEACLTDPVSSNSLPEHGDEDTAGMVTILTEYFVLSSCLVCLHQAAIQAAGSAGMELKNIVEFYRQWKEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHA0</accession>
    <name>A0A3P9CHA0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DCC-interacting protein 13-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adapter protein containing PH domain, PTB domain and leucine zipper motif 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004548854.1">
        <property type="nucleotide sequence ID" value="XM_004548797.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHA0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021665"/>
    <dbReference type="Ensembl" id="ENSMZET00005022378.1">
        <property type="protein sequence ID" value="ENSMZEP00005021665.1"/>
        <property type="gene ID" value="ENSMZEG00005016257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469918"/>
    <dbReference type="KEGG" id="mze:101469918"/>
    <dbReference type="CTD" id="26060"/>
    <dbReference type="GeneTree" id="ENSGT00940000156624"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009891">
        <property type="term" value="P:positive regulation of biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051050">
        <property type="term" value="P:positive regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13247">
        <property type="entry name" value="BAR-PH_APPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07631">
        <property type="entry name" value="BAR_APPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13158">
        <property type="entry name" value="PTB_APPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000034">
        <property type="entry name" value="DCC-interacting protein 13-alpha isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000178">
        <property type="entry name" value="DCC-interacting protein 13-alpha isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000067">
        <property type="entry name" value="Putative DCC-interacting protein 13-beta isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047181">
        <property type="entry name" value="DP13A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037929">
        <property type="entry name" value="DP13A_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047236">
        <property type="entry name" value="PH_DP13A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047237">
        <property type="entry name" value="PTB_APPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415">
        <property type="entry name" value="ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415:SF3">
        <property type="entry name" value="DCC-INTERACTING PROTEIN 13-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="18">
        <location>
            <begin position="278"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="17">
        <location>
            <begin position="501"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="398"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="456"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="631"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="631"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="708" mass="79555" checksum="DDF4E86414823AEB" modified="2019-02-13" version="1">MPGIEKLPIEETLEDSPQTRSLLGVFEEDTAAISNYCTQLYQAMQRIYDAQNELSAATHLTSRLLKEYDKQRFPLGGDDEVMSSTLQQFAKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASDDHDVAINRYSRLSKRRENDKLRAEVVEDVYTSRKKQHQTMMHYFCSLNTLQYKKKTALLEPLLGYMQAQISFFKLGSENLTQQWEEFLGTIGTSVQNVRREMEEEVGQMQQTIQEMERACDALYAPCDPDPAHSPVSRNLTRKQGYLYIRNKTGLVSSSWERQYFFTQGGNLMQQGRGEVAGGLVTDLDNSSVMAVDCDDRRFCFQVTSFDGKKVVTLQAESRKECEEWISTINNISRRIYLSENAEELAARVNQSALEAVTPSPSFQQRHESMRPTSKGRTGRASSISSVGSEPSPALSVLSLDALVAPETPIQFDIISPVSEENSGQSKTAPQSSRRSNPFGESGESTAEDSEDSILHQLFIVRFLGSMEVKTAESVDVISETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLRFPLSTVVQCLSHQDNKRLFGFVLQSASGRSDSRAMCYIFESNNDGEKICDSIGLAKQIALHSEMDRKAVEKKKEEDKAKEKQKEELSKQRQIEKDLEEQSRLIAASSRPANPPGSDGQFLVLSNSQSEDSDAGEEGKKKGESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKS8</accession>
    <name>A0A3P9CKS8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase 7</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cell division protein kinase 7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004544537.1">
        <property type="nucleotide sequence ID" value="XM_004544480.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKS8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022920"/>
    <dbReference type="Ensembl" id="ENSMZET00005023672.1">
        <property type="protein sequence ID" value="ENSMZEP00005022920.1"/>
        <property type="gene ID" value="ENSMZEG00005017161.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463697"/>
    <dbReference type="KEGG" id="mze:101463697"/>
    <dbReference type="CTD" id="1022"/>
    <dbReference type="GeneTree" id="ENSGT00940000155179"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000190">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="12"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="18"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="343" mass="38413" checksum="22E27C70E9A1EE92" modified="2019-02-13" version="1">MALDVKSRAKRYEKLDFLGEGQFATVYKARDKLTDTIVAIKKIKVGHRTEAKDGINRTALREIKLLQELHHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDTSLVLTPANIKAYILMTLQGLEYMHQHWVLHRDLKPNNLLLDGSGVLKLADFGLAKSFGSPSRVYTHQVVTRWYRSPELLFGARMYGVGVDMWAVGCILAELLLRVPFLAGDSDLDQLTKIFEALGTPTEETWPGLSSLPDYVSFKIFPGTPLEHIFSAAGDDLLELLQGLFTFNPSARTTATQALKMRYFSNRPGPTPGPQLPRPNCSAEALREKETVGLKRKIEGLETTAMKKKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPY6</accession>
    <name>A0A3P9CPY6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561020.1">
        <property type="nucleotide sequence ID" value="XM_004560963.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPY6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023841"/>
    <dbReference type="Ensembl" id="ENSMZET00005024624.1">
        <property type="protein sequence ID" value="ENSMZEP00005023841.1"/>
        <property type="gene ID" value="ENSMZEG00005017837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479836"/>
    <dbReference type="KEGG" id="mze:101479836"/>
    <dbReference type="CTD" id="57001"/>
    <dbReference type="GeneTree" id="ENSGT00390000010029"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="123" mass="14649" checksum="85212E5706F6B157" modified="2019-02-13" version="1">MAVCAHVSRVRSLYKRILVLHRFLPIELRALGDQYVKDEFRRHKSAGPKEVKSFMTEWENYKNTLQTQVLESAGERYNSVKFGDHLSHKKLNDFQDEQISQLYELMVESTKSKRQFDIQEDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPZ8</accession>
    <name>A0A3P9CPZ8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550914.1">
        <property type="nucleotide sequence ID" value="XM_004550857.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPZ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024425"/>
    <dbReference type="Ensembl" id="ENSMZET00005025226.1">
        <property type="protein sequence ID" value="ENSMZEP00005024425.1"/>
        <property type="gene ID" value="ENSMZEG00005018259.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469831"/>
    <dbReference type="KEGG" id="mze:101469831"/>
    <dbReference type="CTD" id="22154"/>
    <dbReference type="GeneTree" id="ENSGT00940000154370"/>
    <dbReference type="OrthoDB" id="8388600at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031101">
        <property type="term" value="P:fin regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="444" mass="49687" checksum="B13046CF0E46FB0E" modified="2019-02-13" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRB6</accession>
    <name>A0A3P9CRB6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Si:ch73-22o12.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004550926.2">
        <property type="nucleotide sequence ID" value="XM_004550869.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CRB6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024582"/>
    <dbReference type="Ensembl" id="ENSMZET00005025386.1">
        <property type="protein sequence ID" value="ENSMZEP00005024582.1"/>
        <property type="gene ID" value="ENSMZEG00005018381.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101472823"/>
    <dbReference type="GeneTree" id="ENSGT00940000165364"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052659">
        <property type="entry name" value="Nectin/PVR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47387">
        <property type="entry name" value="NECTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47387:SF1">
        <property type="entry name" value="NECTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018088193" evidence="9">
        <location>
            <begin position="34"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="153"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="251"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="526" mass="56798" checksum="F10DFAEB446786F3" modified="2019-02-13" version="1">MARHDSRIWPECTKMIGLLCLVSSILLHHGASGQRVKVDQEVTSYPGQTVNLRCAFADPTGVQLSMVTWMYVPEPTQDPVNIAVFLPGNEPSYPNSPVKGRVSFVPSPPKVDSPSIQITDVRMTDEGKYACEFATYPGGNVRGTTQLVMLAKPENSASPVTVVAGAKPITVASCKSANGQPAAEISWVTTANGNYTTKQQPGTDNTLTVISEYIMVPMPNDNGKEITCVVSHRTLVKPESFKMNLAVQFAPQVTIEGYDNNWYIGRTNVALTCKANANPPPTTIQWKSTTGEFPPAVQVSENVLKVQNVDESVNTTFFCEVNNQIGTTKEQFGILVREPPKNPSNAGVVAGAVIGSLLALLLVAALIAVLVTRRRRQQQGYRANGGSDMKTRIFGGGKKASKNGTNGGAGNGGGNNNGPIYVYSESSPIQALGEKNNHQLITMGGHPEVVSTTPTAQDILLSNELDDAEKRKFDELDEAENYDHYNPGGPIHLPRSIRDQEMIGEYDDDMESQRDGSVISRTAVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRS3</accession>
    <name>A0A3P9CRS3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with ODC1 and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CRS3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025050"/>
    <dbReference type="Ensembl" id="ENSMZET00005025867.1">
        <property type="protein sequence ID" value="ENSMZEP00005025050.1"/>
        <property type="gene ID" value="ENSMZEG00005018701.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166601"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.60:FF:000001">
        <property type="entry name" value="Ornithine decarboxylase antizyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF11">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01337">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="212" mass="23384" checksum="048AE9E765E602BB" modified="2019-02-13" version="1">MVKSNLQRILNSHCFAREKEGKTQPLTIMANLSSGISFPCTVVVPAARGLCGAPDAPLPPLKIPGGRGNGTRDHTPSARLLYSDRKLTVTEEPPGNGRPGILHFQSRPTVTKTIQWDAVLSSSALYVEIPLDPLPDGSKESFAALLEYAEEHLKVVSVFVCFYKNRDDRAKLVRTFSFLGFEIVKPGHALVPPRPDVFFMAYNFDRDSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CS39</accession>
    <name>A0A3P9CS39_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cyclin-dependent kinase 5 activator</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4. Interacts with RASGRF2. The complex p35/CDK5 interacts with CLOCK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Heterodimer of a catalytic subunit and a regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Endomembrane system</location>
            <topology evidence="17">Lipid-anchor</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the cyclin-dependent kinase 5 activator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570361.1">
        <property type="nucleotide sequence ID" value="XM_004570304.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CS39"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025175"/>
    <dbReference type="Ensembl" id="ENSMZET00005025989.1">
        <property type="protein sequence ID" value="ENSMZEP00005025170.1"/>
        <property type="gene ID" value="ENSMZEG00005018790.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005025993.1">
        <property type="protein sequence ID" value="ENSMZEP00005025174.1"/>
        <property type="gene ID" value="ENSMZEG00005018790.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005025994.1">
        <property type="protein sequence ID" value="ENSMZEP00005025175.1"/>
        <property type="gene ID" value="ENSMZEG00005018790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477257"/>
    <dbReference type="KEGG" id="mze:101477257"/>
    <dbReference type="GeneTree" id="ENSGT00390000008812"/>
    <dbReference type="OrthoDB" id="7676799at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016533">
        <property type="term" value="C:protein kinase 5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035622">
        <property type="term" value="P:intrahepatic bile duct development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000025">
        <property type="entry name" value="Cyclin-dependent kinase 5 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009324">
        <property type="entry name" value="Cdk5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="335" mass="36351" checksum="B81B7B74185699B3" modified="2019-02-13" version="1">MGTVLSLSPSYRKAALFEDGPATVGHYTAVQNSKNAKDAAAAAAKSLKRPSIISVLPWKRIVAVSAKRKGSKKLQSDSGDGGKGSSPDGHAAATTNSASNSLKLKKSQSCANLSSYSSSQDPAATTTTTSSHLPASKTLANVATVVAKKNSLTGSGIQPSTAAGTPKRVIVQASTSELMRSLGEFLCRRCYRLKRLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVVSAEVASERELQASLLTCLYLSYSYMGNEISYPLKPFLVEAEKEAFWDRCLDIINRMSGKMLQINTDPHFFTQVFADLKNESKKEEEKTKLLIGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSZ1</accession>
    <name>A0A3P9CSZ1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 98 member A</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554681.1">
        <property type="nucleotide sequence ID" value="XM_004554624.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSZ1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025147"/>
    <dbReference type="Ensembl" id="ENSMZET00005025966.1">
        <property type="protein sequence ID" value="ENSMZEP00005025147.1"/>
        <property type="gene ID" value="ENSMZEG00005018771.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464234"/>
    <dbReference type="KEGG" id="mze:101464234"/>
    <dbReference type="CTD" id="25940"/>
    <dbReference type="GeneTree" id="ENSGT00940000167863"/>
    <dbReference type="OrthoDB" id="512356at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF9">
        <property type="entry name" value="PROTEIN FAM98A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="489" mass="52105" checksum="B29B431CEBA8D3E7" modified="2019-02-13" version="1">MENDILVSLEDLGYQGPLLEEGALESAVSGGAASPEFTKLCAWIVSELRLYCKLEENVHATNCPSEAEGFQLEMSGLLSELTCPYSVLTSGDITQRFLNRTDCLLLITFLVSELEASRMILVNKPQKKAQESGSPAFQELKGICMALGMSKPPANITMFQFFSGIEKKLKEALSRVPPNHVGEPLLKKPLGPVHMEKIEAINQALVNEYEVRRKMLLKRLDVTVQSFGWSDRAKTHADKLSKVYPPLRSALANKSKVSVAHLLAARQDFSKILRTSSGKIREKTACAINKVLMGRVPDRGGRPCEIEPPPPEMPTWQKRQDAPQIGGHYGGGGHGGGRGGYDHGSQGGRGGYERGAGGGGHGERGSRGGGGRGRGSYNQGYYQDAGGHHGGGGRGGYGGNHQGGFQDPNYHGGGGGGYHDGGHYQDRGGGRGGRGGRGRGGRGGGGQGGGWGGRGGQNFNQGGQFEQFFQHGGQHYSQAGFSQGRHYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVV8</accession>
    <name>A0A3P9CVV8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVV8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026525"/>
    <dbReference type="Ensembl" id="ENSMZET00005027382.1">
        <property type="protein sequence ID" value="ENSMZEP00005026525.1"/>
        <property type="gene ID" value="ENSMZEG00005019784.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271858"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF170">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="270" mass="30431" checksum="75D3AD2178ABB618" modified="2025-10-08" version="2">MPSVINTMVQKNAGRYYSIVMFREGDLRIVVIGRTGAGKSASGNTILGEKAFKAVSSLSSLSSECQKKTGLFDGQKLAVIDTPGLFDTGKTEEEVKEEISRCISLAAPGPHVFLVVIQANRFTEEAQKTVKIIQDMFGEQSARYTMVLFTYGDNLERDEVTIENMISNDPNIFDFIRQCGGGYHVFNNTDKNPSQVRELLEKINTMIATNGGGCYTNEMFREAQRAMNKSEMERLRKENPEMTAKEARYKQDLFSLLYKCLQSYCEHFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CY50</accession>
    <name>A0A3P9CY50_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 235</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CY50"/>
    <dbReference type="Ensembl" id="ENSMZET00005028133.1">
        <property type="protein sequence ID" value="ENSMZEP00005027263.1"/>
        <property type="gene ID" value="ENSMZEG00005020337.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164807"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="431" mass="46697" checksum="7E63E738492CD2CB" modified="2019-02-13" version="1">MSPAATFHAQLASIMEVLANTAVAEICELVDSGYSVLQLEISRSRKENEVLRRKLRLMELRAARATALRAAVTASGSAVLHASGRARAELKRNATATGEVVLSRVSNQAMPQCRDHNSPAEPRQETTQSTPADATTAAVIKVEDDDCVSWSQSEPDKGFCHNEEGQVEAEAAIKQEAANDGGISWTSGEVSSTSTSVQNTQRSETSSYDCLIFEPQLQHGSHTTQNPLGAEAGCSSASNSGGSFTFPHSKVSLSAAERPAGFQSSQQRAVPADELPVRKETPGEHRSFIRRGGWRQDAISRAASHRGEDGGGKSFVCNCCGKKLACLKNLKTHMRVHTGEKPFVCALCGKRFSDSSNLKRHQSVHTGEKRYGCVHCGKRFAQSGSLKVHMTVHTDCKQFRCSYCNKTFISGSHLRRHITLHAGEKRFGAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CY92</accession>
    <name>A0A3P9CY92_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Zinc finger protein 532</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005026786"/>
    <dbReference type="Ensembl" id="ENSMZET00005027647.1">
        <property type="protein sequence ID" value="ENSMZEP00005026786.1"/>
        <property type="gene ID" value="ENSMZEG00005019972.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154437"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003507">
        <property type="entry name" value="Zinc finger protein 226-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001446">
        <property type="entry name" value="Zinc finger protein 532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045914">
        <property type="entry name" value="Zn532-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041697">
        <property type="entry name" value="Znf-C2H2_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057356">
        <property type="entry name" value="Znf-C2H2_ZNF592"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47222:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47222">
        <property type="entry name" value="ZINC FINGER PROTEIN 532-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16622">
        <property type="entry name" value="zf-C2H2_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25412">
        <property type="entry name" value="zf-C2H2_ZNF592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="603"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
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    <feature type="domain" description="C2H2-type" evidence="18">
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    <feature type="domain" description="C2H2-type" evidence="18">
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    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1026"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1056"/>
            <end position="1084"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1200"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1263"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="1231"/>
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            <begin position="44"/>
            <end position="56"/>
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            <begin position="80"/>
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            <begin position="154"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
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            <begin position="1008"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1119"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1237"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1300" mass="142314" checksum="1C9629948DFE0721" modified="2019-02-13" version="1">GCSIRFDMKTPDFDDLLAAFDIPDMVDPKAAIESGHQDDHDGQLKQTSGGVTNSENEAQHPSAAHDVGVSVIVKNTRNLDTSDHCGTESERGRHFHSHSRLPSVHNGLHNILVSTIPTGAQYTKNGCKIPREEGQKMNNESCTFNQFSPISSTEEFDDDEKIEVEDPGDKQGGHTARKGERNSKSAKRESLSKPKTNGDQKPDLNNNNSGTFRSCKFKNLSQPTLPEGKLEETMPKSHSKECQEGGQSSGLGNPSSLSQVKSKSSTKLSSCIAAIAALSAKKAGAEDLGTLDSPTTQQEPAQVKENSRVPEKPQDQESAMEIAKRLLTRQPDSPSSVTSERSSKGSPASNTDTTPVIPKVRIKTIKTSTGQIKRTVTRVLPEFDPEGLKKRENSTSVMTTNNPSAIFSTTVLTTTGGPSIEITKQMTIKPVATAFLPVSAVKTAGSQVINLKLANNTTVKATVIPAASVQSASSAILKAANAIQQQTVMVPASSLANAKLVPKTVHLSNLSLLPHTVSSAACDLQHTLYKQPQHQQSQQAKQQTILTSQQSKKVSRVQVFTSSQSSVVDAFNKVLSSMNPVPVYIPNLSPPTSACISLPSLGYKCLECGDSFALEKSLTQHYERRSVRIEVTCNHCAKSIVFYNKCSLLSHARGHKDKGVVMQCSHLILKPIPADQMIGTSAAGPHSVNGTTTTTQAHAPAGQMQDKVSGAGNQPAVISAPSSAPVVAAMPLEDDASKLCRHSLKCLECNEMFQDDNSLAMHYQQASEPRSQKTCTICQMLLPNQCSFLSHQRIHQHKSPYICPECGASCRSVHFQSHVTKNCLHYTRRVGYCCIHCSVIFADVATLKSHIQSAHCEVFFKCPLCPMAFKSAPGTHSHAYTQHPGLKAGEPKMIYKCSMCDTVFTLQSLLYTHFDQHIINHKVSVFKCPDCSLHYAQKQLMLDHIKAIHGTLKTTEGPPNLGINLPLSTKPTNSNSTNSKSPRNNNKDGRNINGQNKGEKKPSALSVKKNNSNCSEDLKSPPSSGYTCKDCNSLFSSRELFVVHMRREHGKMLKKHPCRQCDKSFSSSHSLCRHNRLKHKGLRKVYTCPHCPALSQPFTKRVLLDQHVQLMHGVKDVGGKTHNMEALPDKEKVLLSPKRKTEDDEGDPGLNSRGTISQPLKRLKVNILKVHKCAVCSFTTEDFAAFQEHIPQHKSDGSSYQCQECGLCYTSHRSLARHLFIVHRLKEPQGLGRYNGRSKEDEESQRENQFDVTDENSDGTPNTKCKVCGKMFETEGNLNTHMRTHGMAFIKARRLSAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2D4</accession>
    <name>A0A3P9D2D4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase/reductase SDR family member on chromosome X</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564181.1">
        <property type="nucleotide sequence ID" value="XM_004564124.2"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005028266"/>
    <dbReference type="Ensembl" id="ENSMZET00005029164.1">
        <property type="protein sequence ID" value="ENSMZEP00005028266.1"/>
        <property type="gene ID" value="ENSMZEG00005021079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479280"/>
    <dbReference type="KEGG" id="mze:101479280"/>
    <dbReference type="CTD" id="207063"/>
    <dbReference type="GeneTree" id="ENSGT00940000168183"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="325" mass="35781" checksum="6E77F62B1F5AF4DF" modified="2019-02-13" version="1">MSLQSVLVPLFKLYLCGIKVLLYQIFNRSFTLPVLPKQNGRVAIVTGGTRGIGFETARHLASLGMHVIIAGNEREEGAAAVRKIHEEGTEGTAEFVFVDMTSLKSVRHFVRLFRDRGLPLHVLVNNAGTMMVPDRQTEDGFEYHLGLNYLSHFLLTNLLLDLLKRSGKPGCCSRIINMSSATHYAGVIDMEDLNRRIQYSSHGAYSQSKLGLVLFTYYLQEQLTASSCSVTVNAVDPGMVDTALYDNLWTLVQLLKKPVAKILFRTPAEGASTAVYAAAASEMEGVGSCYLYNGQKTQSAGVSYDSELQAKLWKKSCQLVGLQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4N0</accession>
    <name>A0A3P9D4N0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hemoglobin subunit alpha-A-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in oxygen transport from gills to the various peripheral tissues.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer of two alpha chains and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the globin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4N0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029600"/>
    <dbReference type="Ensembl" id="ENSMZET00005030534.1">
        <property type="protein sequence ID" value="ENSMZEP00005029600.1"/>
        <property type="gene ID" value="ENSMZEG00005022075.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163288"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072562">
        <property type="term" value="C:blood microparticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031838">
        <property type="term" value="C:haptoglobin-hemoglobin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005833">
        <property type="term" value="C:hemoglobin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031720">
        <property type="term" value="F:haptoglobin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043177">
        <property type="term" value="F:organic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08927">
        <property type="entry name" value="Hb-alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000002">
        <property type="entry name" value="Hemoglobin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002338">
        <property type="entry name" value="Hemoglobin_a-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050056">
        <property type="entry name" value="Hemoglobin_oxygen_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11442:SF93">
        <property type="entry name" value="ALPHA GLOBIN-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11442">
        <property type="entry name" value="HEMOGLOBIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00612">
        <property type="entry name" value="ALPHAHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="10">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="143" mass="15698" checksum="671D2EDAA9E1A862" modified="2019-02-13" version="1">MSLSAKDKAVVKNFWAKVSPKSAEIGGEALGRMLTAYPQTKIYFSHWSDLSPSSAQVKKHGATIMAAIEDAVSKIDDLTGGLSALSELHAFKLRVDPANFRILSHNIILCMGMFFPADFTPEVHVSVDKFLQNLALALSEKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D685</accession>
    <name>A0A3P9D685_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lysosome-associated membrane glycoprotein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytolytic granule membrane</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Late endosome membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Lysosome membrane</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551329.2">
        <property type="nucleotide sequence ID" value="XM_004551272.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D685"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029606"/>
    <dbReference type="Ensembl" id="ENSMZET00005030540.1">
        <property type="protein sequence ID" value="ENSMZEP00005029606.1"/>
        <property type="gene ID" value="ENSMZEG00005022082.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101485063"/>
    <dbReference type="CTD" id="563328"/>
    <dbReference type="GeneTree" id="ENSGT00950000182899"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.110:FF:000001">
        <property type="entry name" value="lysosome-associated membrane glycoprotein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018134">
        <property type="entry name" value="LAMP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF27">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00336">
        <property type="entry name" value="LYSASSOCTDMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00311">
        <property type="entry name" value="LAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018051208" description="Lysosome-associated membrane glycoprotein 1" evidence="16">
        <location>
            <begin position="30"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="17">
        <location>
            <begin position="45"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="18">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074383"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="246" mass="27078" checksum="664F625B357C02B2" modified="2019-02-13" version="1">MVQICRVQSWFVGVTPLLIFVTVLHQGFATVAPPTPAPHKEPGRPERGHYNVTNNGTICLMAYMGLQLNISYNSTSQKKVVQDVMNLQPNLTKHSGSCDSEIASLQLTVDAVKTNLIFVFTMNSTSNKYHLSEVNVSAAWPDMKEHISGHNSSLDYLRGTVGYSYYCRDEQTLNVVQNLSINTFQLQVQPFAVKGDQFGAAEECQLDEDDMLIPIVVGAALAGLVAIVLLAYLIGRKRSHAGYQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7X8</accession>
    <name>A0A3P9D7X8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Visual system homeobox 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
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        <property type="gene ID" value="ENSMZEG00005022517.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OAR_dom"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="83"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="11">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
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            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="248" mass="28339" checksum="43B296532EDF48F2" modified="2019-02-13" version="1">MFGTGQLVSSLLPAVFHSPAAHFFPAFPARLGSQPQFLIPGPFISYESLRNYLQPELCKEALLMATQAVRIGPLTESIEQRPVKQRRARANYSSWQLEELEKAFETTHYPDIFMREALALRLDLIEARVQVWFQNRRAKMRRQLKLQGQCPGPYVKRDNDETSPKASKSLKHAERSDGEHWEKQQEAEGYPWTTQKLGKWERPEGPSSEELRSCSIAKLRAKAREHEAEIQGNVSMSGGTKQSQTQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D814</accession>
    <name>A0A3P9D814_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UV radiation resistance associated gene</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
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                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004561682.1">
        <property type="nucleotide sequence ID" value="XM_004561625.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D814"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030835"/>
    <dbReference type="Ensembl" id="ENSMZET00005031814.1">
        <property type="protein sequence ID" value="ENSMZEP00005030835.1"/>
        <property type="gene ID" value="ENSMZEG00005022971.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484718"/>
    <dbReference type="KEGG" id="mze:101484718"/>
    <dbReference type="CTD" id="7405"/>
    <dbReference type="GeneTree" id="ENSGT00390000012877"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="744" mass="83671" checksum="D88A58C49E93538C" modified="2019-02-13" version="1">MNSITGRVLAIPAASVTNSGASASRALHVELTSQQRRLRHLRSIAARNIVNRNGSPLLDTYFTLHLCIGDRISRDFYKSEVIRDSLNPTWRSLDFGMLPDLLDTSVSCFVVRIWGGQKEQYQLLIEWKVNLDGLRYTGQQIRSRNPNEIIFGLNDGYYAADFDQKDQSERKKNSLLQVDQSSVRNSYSVFSLLRLHTAQRAIKQTQVTVQKIGKEIEEKLRTTAACTERKKERECMQLRIAVLHSELERQRKALGRERDLRQKERALLQKKEDSFSAQHERLKEEKESLSKLQKECTAKREQFLKSNAQLTFRCRQLLSELSYIYPIDVTNQSDYVICGVKLPNSEDFQAKDDGSIAVALGYTAHLVLMISCFLQIPLRYPVIHKGSRSSIKDTITDRLTEKEREFPLYPRGERFHFEYGVYLLNKNIAQLRYQHGLTTPDLQQTLPNLKNFLEHGLMVRCDRHHVSSSIPVPAKSQLGVSAASELAYPCHTSSPDRGLRNRASSEAEAELKYKPATPPPSYNTAISEGKSQVGLGPPSPSPSPTHLSSSLDPSKAPLDLSTNTETIVEEEQKEEKQEARGTAVEAEGRETAEGESERHKENKSDEMEENPSSSSMIPNSSAVQDADEETMPAAQHPGAMNGSLVLEQAPISLIPELRCSVEQAEEIMGTEATGLGLGMGLGLADEARLDDYRCIPVDHAVAVECDEQVLGELDMAGFEEFSRRIYALNENMSSFRRPRKNSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8U3</accession>
    <name>A0A3P9D8U3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004568687.1">
        <property type="nucleotide sequence ID" value="XM_004568630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8U3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030988"/>
    <dbReference type="Ensembl" id="ENSMZET00005031986.1">
        <property type="protein sequence ID" value="ENSMZEP00005030988.1"/>
        <property type="gene ID" value="ENSMZEG00005023100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484845"/>
    <dbReference type="KEGG" id="mze:101484845"/>
    <dbReference type="CTD" id="11230"/>
    <dbReference type="GeneTree" id="ENSGT00390000008631"/>
    <dbReference type="OrthoDB" id="18213at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859:SF1">
        <property type="entry name" value="PRA1 FAMILY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859">
        <property type="entry name" value="PRA1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="178" mass="20104" checksum="8B7DA3D172E5DEBE" modified="2019-02-13" version="1">MAGVQPPPLRSLDDFLLCSTRFATPDVRNLDRWNNRIINNLLYYQSNYFLCVLGFLLIVGYFEPFQLFTGMTVVTLLFTGFVWAAENQAPIRRFRRNHPTVSMLAILVASYLFISVLGGVAVFLFGIAFPIFMVLIHASVRLRSLKNKLENKLESIGLKRTPMGILLEALGQEQEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAA7</accession>
    <name>A0A3P9DAA7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuole membrane protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAA7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031294"/>
    <dbReference type="Ensembl" id="ENSMZET00005032305.1">
        <property type="protein sequence ID" value="ENSMZEP00005031294.1"/>
        <property type="gene ID" value="ENSMZEG00005023328.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007230"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="431" mass="48060" checksum="B21C894750981D85" modified="2019-02-13" version="1">MNEMAKCGAEGELLQRRLGVKEQQNGELGEDSGLPADGGRQTDLDEREALVLWKKPLLTLHYFTLELLITLKGWTWRLWQQRQTVFGLLTLLTLLSIAYRIEGAHTQYVCYMEKKTLWCAYWVGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECGSVDFPEPPYPEQIVCPQQEAPASDSGAEQVGVEAVGSETLQGKVSLWTILSKVRLEACMWGVGTAIGELPPYFMARAARLSGTEPDDEDYQEFEEMLDQAEATQDFSFRAKVSVQKLIQKVGFFGILACASIPNPLFDLAGITCGHFLVPFWTFFGATLIGKALIKMHIQKLFVIITFSKHIVEQMVSLIGSVPLLGAALQKPFREYLEAQKAKLHHLTGEGIPAEESWLSWLFEKVVVIMVCFFVCSIVNSMAQSYAKRKRQEKYSESKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DBB0</accession>
    <name>A0A3P9DBB0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spectrin beta chain, non-erythrocytic 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DBB0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031392"/>
    <dbReference type="Ensembl" id="ENSMZET00005032407.1">
        <property type="protein sequence ID" value="ENSMZEP00005031392.1"/>
        <property type="gene ID" value="ENSMZEG00005023396.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00980000198690"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="926"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1149"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="872"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1227" mass="140221" checksum="C8718D62231F0A3A" modified="2019-02-13" version="1">KMLMARDTARDEAQKLHRKWLKHQAFMAELARNKEWLAKIEQLQEGQELIQEKPELRSVVQQKLEEIRECWSDLETTTKAKARQLFENNKPEPAVKSYSDLDNQLSHLEQQPPQLEQAHHLPTFNEQLQKFQLMAGDKEVGEQSGEVETRIVRLIEPLKERRRILLASKEMHQVAQDLEDEILWIQERLPLATCKDYGNNLQSVQQYIKKNQAIQRELTGRRARIEEVLDRAAIIASLRTPEVEFVREGAGHVRQLWEVLQLETERRSVLLEAALQAQQYYSEAAKVESWLSGQKLNLASEEKGTDEASTLQLLKTHLALEQTVETYAETVGMLSQQCQHLLELGHPDEQITKQQSHIDRLYVSLKDMVEHRKMKLEQQYWLYQLNKEVEELEKWITEREAVASSTELGQDLEDVTVLQERFTKFASETNSIGQQRMEQVNKMVNEMIDCGHSDAATIAEWKDGLNESWADLLELMETRRQMLAASHQLHKFFTDCKEIAGKMKQLPEVRACQANITNPATLQRLMHSFEHALQLLVAQQVRQLQENAAQLRTIYAGEKAEAIMVKEQEVMDAWKELLSSCEASRVQVTSVTDKVQFFSVVRENLMWMEGIMGQIGWDEPDLTALEGMMRQHQELKAKIDGRSKTIQQCADLGKILIAAGNPASEEQIKEKLDSLLTKQKDLVEKWDKHQERLQRQEKFQFAQETVKAEAWLKAKEPLITTRHQEGGVAQAQTDEVEQLILRHEAFRKAAVTWKERFSSLRQSNMGSSGYLAQNYQSAGGLGSSGYLAQNHYSSGSLGSSGYLAQSGGIMDPKMAYAWQHLKADFMQPRINHIHKAVNPLLEASRVQREQFGDIPMADMMGPESGLELLHGRLQRDPRGSRSDPQMDHLRREREYKLGRQTSSEQEIQARLNELPLIVRQERYRRRLERQSSSEQEGSGKQRLQRQDSSDLEGSAKEGSDKRSEKRNTMAEIVEQVQEREAAHARGEPYRPPSSLSAPVTRFDGRPRARDRPKPRRRPRPKEPEETRRSRSAPATGAPTTPQPPSHTAHNEGSLYRKKATSSDLEAQQRSPNKSWVNVYCVLKDGKLTFYKDARNHNTTYNGEPPVDLSNCSFDPSMGYKKKKNVFILEDLKAWTSTITTCIAEHEAMGTWDKPGTSSMDPDRSERKEKSEGDADARSERSELVEGEERSEKERSEKGDGSEKLDTSEIADKLEGGAGGSSTSGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DBQ2</accession>
    <name>A0A3P9DBQ2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized LOC101483920</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Zona pellucida</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZP domain family. ZPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567963.2">
        <property type="nucleotide sequence ID" value="XM_004567906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DBQ2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031963"/>
    <dbReference type="Ensembl" id="ENSMZET00005032997.1">
        <property type="protein sequence ID" value="ENSMZEP00005031963.1"/>
        <property type="gene ID" value="ENSMZEG00005023839.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101483920"/>
    <dbReference type="GeneTree" id="ENSGT00940000163253"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035805">
        <property type="term" value="C:egg coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032190">
        <property type="term" value="F:acrosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035804">
        <property type="term" value="F:structural constituent of egg coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060468">
        <property type="term" value="P:prevention of polyspermy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017957">
        <property type="entry name" value="P_trefoil_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051148">
        <property type="entry name" value="Zona_Pellucida_Domain_gp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23343">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23343:SF117">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00025">
        <property type="entry name" value="P_TREFOIL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0278">Fertilization</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="18">
        <location>
            <begin position="926"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="17">
        <location>
            <begin position="968"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="661"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="928"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="938"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1233" mass="136795" checksum="CF5C01287B65250C" modified="2019-02-13" version="1">MSCKQKRGKSTFLFVATVYFYVFQLCCSVSLGQWEDGFTATEGERIKQDKTPAGQHTGTGYGDLRESNEQRLHKLQLQPGSGEPHPHLSAQDLKKSDVKFVPESLSWNIGNVSVKPKSSTPESVYGHQADFTGFQGEVLGLSSESSTHFSEWQAMSPLVECDDDVMVFTASGQGFTQLSVDRVGTSPISVFQLPPYCGYTLRTSWSDLEMMVPYDACYITQENNSYMLPLLWWGTPLKLSCPIRISTPTPLFPLSPPSVFCSSFGMAVQIHAQEKDIPALGVKVNGALHPFVSEQCAYYIDSQSEEHTLFIYSSAPCFTSRDGLQLELVFGDNEYILSCPVTSWFPYAPSTPWSPPLSPDNPQYPNIPDPVGPSPPPPPTPEHGKFPGYPDYSYPGLQFPQLPQFLQLYPPGPQAKEPPQPTGDSPPGYQPNFPGKSPYSFGSLKYPPSHYRSPVMVLARPDPNPRPLENGQSPHQVPNLPPQYLFDYSHMSFYYPTVTPATTTPPQTTTTTVPPLTKPAKPPSHPLYPQYYLQMPYYPEPVNQPPVPLPPGPQYPPPSQSKQPIGPPASSYSSYYGYWPVSYQKPSAAPLDPIKTRGYNFLSNLFYLQPAESPTPANEEPQKPVPQEICLPYSHTICSSYPYHVYHTLYPPHYIPPHPPLPRYPEIQPPVTTPKPSTTTTTPPTTSSTTPAGPSPWTPNLQCMTGRMVAFLPFTHPDSIQVKDQTNIWTFVSSVAPFCGYMLQMTEGFGVILHSPLPACHSYLQTPTTISLPLRFWDFSMAQYRTVDLECPFQSPSDNLATDAPLPTPTPPSTTKDVIGPSAVPKPKIFCSSHEMTVELPFGPISEIVVKDIKGNQMNLKDAPKQCGYSASKGKDGKIHLNLQLHSRCHMSVQGTLYIITVIYMTLNGKKESQFSCPVTISGPRQECNLPHEQRLPCGSSSLSQTQCLSMGCCFNKHPPACYYPMDECTIDRHFVFSVPASITEPPLSPALLVAAGNFTCRPQKVTSDYALFKIPMDGCGTRRVMLGETVVYMVEVINMVQAISLNYGTITRDSPVRLLVECRYMPGTVLTVSYIVKTPTLGPEIQSYGAFGVQLRIAEDDQYKRYYPQYHQPLKMMLGKPLNLEVRLLNSPDPTLVLLVHFCVAYPRSGKAVWVLLYNGCPNPLDPAPPQAVPSHPQPLSPDAQTRRFTITTFQFLPDGEFKDLDEEIYFMCSTEICSPRDGPCVEGCFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DC36</accession>
    <name>A0A3P9DC36_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase ZFP91</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase ZFP91</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zinc finger protein 91 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with MAP3K14/NIK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004564403.2">
        <property type="nucleotide sequence ID" value="XM_004564346.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DC36"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031706"/>
    <dbReference type="Ensembl" id="ENSMZET00005032738.1">
        <property type="protein sequence ID" value="ENSMZEP00005031706.1"/>
        <property type="gene ID" value="ENSMZEG00005023657.1"/>
    </dbReference>
    <dbReference type="CTD" id="80829"/>
    <dbReference type="GeneTree" id="ENSGT00940000156393"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000183">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000356">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="688"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="770" mass="84779" checksum="B9F4AF76AD42A792" modified="2019-02-13" version="1">MEPAGDRTGNVNKGEDPTEDKAAEETPGTSTAGTPRRALRDRGAGRPRSGVTASVADVNGGTSSPQTSGRVLRDRSTRAVPAWLKDTKSSDDDEDEPSSDAGATKRRKVSNSRRKKNSDTAGSAEGYSLQGTEQEDAKKPATDAQALPSRRPSAQTHAKTPSGRAVHSSAKPMCKTEPGMENPAAVEGAVDDKDKYEIEKKEEENTGAAEPGLDDEDPSFQDDPDNLTYQPQSQSVEEEEVLSSEEDVPFRDDLNDQSYDPKVERDAPKPKRRVPPRPKEKKEKEKPLKKEKEVAEIKVEGSDNVESMQEEVKLEEEVVEDPDGPRKRGRRKKDDKTPRLPKRRKKPPVQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLKKKYVCPHPSCGRLFRLQKQLLRHAKHHTDQRDYICEFCARAFKSSHNLAVHRMIHTGEKPLQCEICGFTCRQKASLNWHMKKHDADATYQFSCSICGKKFEKKDCVVAHKAKSHPEVLIAEALAANAGALITTPASLLELPGNPAQAEVTGLDANQVGQDGQVDQLGQDGQHVPQVSQMGHVTQQVSHQVVLLGQDQSLHTMQVPVTIALSPIDPPSPAENQQQTQLQLQMPVQFVQTAQQPQIQQLTLHSNSVVTQHQPQLQPLQSYTSQQQSQGQTQILQMTFQPVSQSQTHIQQIPILAASQQLQPLQTASPSPPLMSTSQTQSQVPVSTSGDSFMLDNPVLSSSSPSATSLQQTEVVGEDGVIWEQAGQGEVLADGTGRHMQQTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCS6</accession>
    <name>A0A3P9DCS6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoplasmic reticulum resident protein 27</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567968.1">
        <property type="nucleotide sequence ID" value="XM_004567911.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCS6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031957"/>
    <dbReference type="Ensembl" id="ENSMZET00005032991.1">
        <property type="protein sequence ID" value="ENSMZEP00005031957.1"/>
        <property type="gene ID" value="ENSMZEG00005023835.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485237"/>
    <dbReference type="KEGG" id="mze:101485237"/>
    <dbReference type="CTD" id="121506"/>
    <dbReference type="GeneTree" id="ENSGT00930000151058"/>
    <dbReference type="OrthoDB" id="8667660at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF253">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018056347" evidence="2">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="254" mass="28132" checksum="5D175545A9273097" modified="2019-02-13" version="1">MPGALFLCLLVSSVIAAEKDSALPGLNNTKDVEAFIDSAEVVVIGFLEGEESYGYKELVEAVKQVSSVPAAICSVKEVWAEYNLSSDAITLFRKADNHQENIDLSEAKDLKADGLVNFISVNEIRYITEYSQVTAVGLFNSEVKTHLLLLANRGSKDFVELKERLGALAPEYTGKFLFVLLNGALKSNLKPLEYFGLKPKDLPRVGIYDGNSDTKWLLPEGEISTERVREFCESFLRGELKGMKEAEEKPKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DD85</accession>
    <name>A0A3P9DD85_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004565617.2">
        <property type="nucleotide sequence ID" value="XM_004565560.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DD85"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032111"/>
    <dbReference type="Ensembl" id="ENSMZET00005033149.1">
        <property type="protein sequence ID" value="ENSMZEP00005032111.1"/>
        <property type="gene ID" value="ENSMZEG00005023933.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470862"/>
    <dbReference type="KEGG" id="mze:101470862"/>
    <dbReference type="CTD" id="10714"/>
    <dbReference type="GeneTree" id="ENSGT00940000163239"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.20:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="443" mass="49820" checksum="9CBAD5823ACB168E" modified="2019-02-13" version="1">MDELYLDNIDEYVNDHNKIVTYKWLSLTLGVHVNTAKQMLYHYLDHKRKESSAQLHATYLVSGKFVDNGQTSHKVSVVREDQLEDFKAKMSLVVSVHVYSVQRALLRDSGPLYAVDYDAVKDNLKNCSRYSAIHCASAVPMSSVELQQAREVQQAPTPEAENKKAGMNGDTSPVLKSSAKPPKGIMGMFANKSAPKSQDNTKEMKPEKKEDIEAPKSKPVAKANPVANFFGTQTLKKPEKPVKEEEAPQSSSRAAQQHERSKPEEKQETVAPVEPQIDTKKDSRSKTKRLEDSDGEEEKMEKKKRRRIKKPEPDSSDEDVIPDSPQPVVTREPSSPSPKKEVEPDRHSHPSSSEMKIRKRRRVMKSHTFLDDDGCMVTEKGYVSESYSESEDDFKPSKQASRDPIKAKPSSSKEDEKKTQKKASANSNKGAKQASIMGFFQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDU3</accession>
    <name>A0A3P9DDU3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Metabotropic glutamate receptor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DDU3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032663"/>
    <dbReference type="Ensembl" id="ENSMZET00005033721.1">
        <property type="protein sequence ID" value="ENSMZEP00005032663.1"/>
        <property type="gene ID" value="ENSMZEG00005024331.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234595"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008066">
        <property type="term" value="F:glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007206">
        <property type="term" value="P:phospholipase C-activating G protein-coupled glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15450">
        <property type="entry name" value="7tmC_mGluR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06374">
        <property type="entry name" value="PBP1_mGluR_groupI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000219">
        <property type="entry name" value="Glutamate metabotropic receptor 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000337">
        <property type="entry name" value="Metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000202">
        <property type="entry name" value="GPCR_3_mGluR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019588">
        <property type="entry name" value="Metabotropic_Glu_rcpt_Homer-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10606">
        <property type="entry name" value="GluR_Homer-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01055">
        <property type="entry name" value="MTABOTROPC5R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01229">
        <property type="entry name" value="GluR_Homer-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00979">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="798"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="21">
        <location>
            <begin position="578"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1102"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1111"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127362" checksum="A4EBEEBD74AB585E" modified="2019-02-13" version="1">MIKNSILNALFVEVGVNAQNNERRVLAHIPGDIIIGALFSVHHQPPADKVHERKCGAVREQYGIQRVEAMMHTLDRINADPTILPNISLGCEIRDSCWHSAVALEQSIEFIRDTLVSSDEEESQGRCTAEGGSMLLQGKKPIVGLIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKSLYKYFMRVVPSDMQQARAMVDIVKRYNWSYVSAIHTEGNYGESGMEAFKDMAAKEGICIAHSDKIYSNAGEQSFDKLLQKLRGHLPKARVVACFCEGMTVRGILMAMRRQRLVGEFVLVGSDGWADRYDVTNGYQKEAAGGITIKLKSAYVTWFDDYYLNLKPDANLRNPWFPEFWQHRFQCRLKGHPQESTAYNRTCTWRESLRHQYAQDTKMGFVINAIYSMAYGLHAMQQALCPGYKGLCESMRPIDGRKLLDFLMKTNFTGVSGEAILFDQNGDSPGRYEIMNFKQTGEDEYAYIHVGSWDQGGLKMNDEEIWSNNSEIIQSVCSEPCQKAQIKVIRKGEVSCCWTCTPCKENEFVFDEYTCRACELGSWPTDDLTGCEPIPVQYVRWGDPEPIAAVVFACLGLMATLFVTSVFIKFWDTPVVKSSSRELCYIILAGICLGYLCTFSLIAKPHIVYCYLQRLGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFLLILLQLGIIVALLIIEPPQVIYDYPSIREVHLICNLTTLGVVAPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALCCMFVPKVYIMLAKPEKNVRSAFTTSTVVRMHVGDAKKAAKSGKSSSSMANLFRRRGSTQDNIRYKLALTWEYVTSFGLLTAIHVIFSSNGKSVTWTQNERGYRPNLWKRMSFHVKKKDPVEANQTAIIKPFSKDGDTPADNGVKEQYEEPQLSQSFTYISIIGVGDIGIGMIGGQTQGTTIMDQISSVVNRFTANISELNTMMLPGGATVSPPSTTALPAATADTTACPPQYLAPRNRQTPSTVTTYAEVTAVSSFCENRPAGKIYEHLAGTCVSSRRAKDMEELMALTPPSPFRDSSLSSNGSSPPSLSPASEAEYDQLLLRHYSQSSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DE25</accession>
    <name>A0A3P9DE25_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family with sequence similarity 222 member B</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004575573.1">
        <property type="nucleotide sequence ID" value="XM_004575516.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004575574.1">
        <property type="nucleotide sequence ID" value="XM_004575517.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014268188.1">
        <property type="nucleotide sequence ID" value="XM_014412702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DE25"/>
    <dbReference type="Ensembl" id="ENSMZET00005034008.1">
        <property type="protein sequence ID" value="ENSMZEP00005032940.1"/>
        <property type="gene ID" value="ENSMZEG00005024538.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005034010.1">
        <property type="protein sequence ID" value="ENSMZEP00005032942.1"/>
        <property type="gene ID" value="ENSMZEG00005024538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485279"/>
    <dbReference type="KEGG" id="mze:101485279"/>
    <dbReference type="GeneTree" id="ENSGT00530000063811"/>
    <dbReference type="OrthoDB" id="8950865at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029340">
        <property type="entry name" value="FAM222"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16070">
        <property type="entry name" value="PROTEIN FAM222A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16070:SF1">
        <property type="entry name" value="PROTEIN FAM222B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15258">
        <property type="entry name" value="FAM222A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="677" mass="73551" checksum="D72A49B7068B98E6" modified="2019-02-13" version="1">MLARLPASVKPTIRLLSRTQMNTGPPKWETTQKMRSASYPTPAELDAYAKKVANNPLTIQIFPSSVKVPQKKHIRRTVNGLDTSLSNQRQSPYSSQVGTSGGLLAVLCAPVKNSDTSHTRQLHNSVMNPHSGPYTTESTLNHPQPAPHLQGPSQSALQKQNLVHPQALQQQHRLTHPMALQQPHPQALQQRNMARSQALQQQQSLSQIQAPQQQRLAHPQGMQRQQSLPHTQTVQQQPQQGQSCSSVVPQQHLSHLQSLKHQVAPPQALHSQQGVTQDLRHISDGSQLPSMQHTQGLVGSQALPQAVAAGPPTMPNCPQQARLGPYGPQKLPDPDAPPNITVSTSTIPLSMAASLHQNRPGDLSIIVHQINQLCQARAGMGTTSVCEGQIANPSPISRNLLINASSRVSSHHPALGNVPSSLMVGPPDKAAAQAPSVSLNSQQSIAAANSVPAFHTNPEKVAQQQLQHHLHQQKQQQQQHFQQLQQLQQQRSWAQHQLAHMQQPPEGANPCKNPRMEPPAECAFPSRNLSYSHKLPNSAQSFPLNHPAEKPQPSSPVKCPASSMPYINGHYMKPPWSSVQATAGNNGPQDLSVAFQGGQAAASRDRIPGAKYRPGKEGPNDQSELMQNVDFLGGDFQMPSFQEQNVDAMGNIHRSARSQVQEPGSSGAVHAHRPGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEY4</accession>
    <name>A0A3P9DEY4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Solute carrier family 8 member 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DEY4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033043"/>
    <dbReference type="Ensembl" id="ENSMZET00005034138.1">
        <property type="protein sequence ID" value="ENSMZEP00005033043.1"/>
        <property type="gene ID" value="ENSMZEG00005024639.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158344"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000001">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000003">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NCX, central ion-binding region"/>
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        <property type="entry name" value="CalX-like_sf"/>
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        <property type="entry name" value="Calx_beta"/>
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        <property type="entry name" value="Na_Ca_Ex"/>
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        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
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        <property type="entry name" value="NaCa_Exmemb"/>
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        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
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    <dbReference type="PANTHER" id="PTHR11878:SF8">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER 2"/>
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        <property type="entry name" value="NACAEXCHNGR"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
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    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
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    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
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    <feature type="chain" id="PRO_5018304732" evidence="21">
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            <begin position="26"/>
            <end position="948"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="98"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="154"/>
            <end position="174"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="773"/>
            <end position="797"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="923"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="418"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="551"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033043.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="948" mass="104932" checksum="F3AF27C82765126F" modified="2019-02-13" version="1">MSLSASPAPFLLFFLFLLPLPPCQPESQRSDPSMNPDPRTALPSIFPSSSVLPSLSNDNSTSPSIGDKCDEVTVCKPGILLPVWYPENPGVGYQVARAVVYFLSLMYMFLGVSIIADRFMASIEVITSQEKEVTITMPNGETSVMTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHEFKAGQLGPGTIVGSAAFNMFVIIGICVWVIPNGQSRKIKHLRVFFITAFWSIFAYIWLYLILSIISPGVVEVWEALVTLLFFPVCVILAWIADRRLLFYKYMGKRYRADKRHGIVVETEGDLTPNKGGMEMIIDGKFPARGGTVVPAENCGGGTQDGTTGATELDESRKEVIRILKELKQKYPDKELDQLVELANYYALLHQQKSRAFYRIQATRMMIGAGNVLKKHAADHARRTAVADEEAPEDDDMAVCSRISFESPHSQCMENCGVLMLAVACQGGLGENTFYVDYRTEDGSANAGSDYEYTEGTLVFKPGETCKEIKIGIIDDDIFEEDEHFFVRLLNLRVGDAEGMFESDEVGAAPKARLVEPLVATVTILDDDHAGIFTFSERMVRVSESVGTMELTVVRNSGARGTVILPYHTESGTAKAGEDFEEARGELEFTNDQTSQTLQVRIIDDEEYEKHENFFIVLEEPRWLKRGISEGQMTAEEEEARRIAEMGKPILGEHSRLEVVIEESYEFKSTVDKLIKKTNLALVIGTHSWREQFVEAVTVSAGDEREQGSREERLPSCYDYVMHFLTVFWKVLFACVPPTEYWNGWACFFVSISVIGLLTAIIGDLASHFGCTVGLRDTVTAVVFVALGTSIPDTFASKVAAIQDQHADASVGNVTGSNAVNVFLGIGVAWSVAAVYWRIKGKEFQVDPGSLAFSVTLFTIFAFICMSVLLFRRRPSIGGELGGPKGSRLLTTLLFLGLWFLYILFSSLEAYCHINGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DG18</accession>
    <name>A0A3P9DG18_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Insulin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Heterodimer of a B chain and an A chain linked by two disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the insulin family.</text>
    </comment>
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        <property type="protein sequence ID" value="ENSMZEP00005033081.1"/>
        <property type="gene ID" value="ENSMZEG00005024670.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164327"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000252">
        <property type="term" value="P:negative regulation of feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000228">
        <property type="term" value="P:positive regulation of pancreatic A cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031667">
        <property type="term" value="P:response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003309">
        <property type="term" value="P:type B pancreatic cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04367">
        <property type="entry name" value="IlGF_insulin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.100.10:FF:000003">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004825">
        <property type="entry name" value="Insulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11454:SF9">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11454">
        <property type="entry name" value="INSULIN/INSULIN GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00277">
        <property type="entry name" value="INSULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9 13" id="KW-0372">Hormone</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018083355" description="Insulin" evidence="14">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="15">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="100" mass="11331" checksum="F3488FD902A1806A" modified="2019-02-13" version="1">MVSLWLQTFSLLVLMMVSWPGSQAVGGPQHLCGSHLVDALYLVCGDRGFFYNPRRDVDPLLGGENEVTFKDQMEMMVKRGIVEECCHKPCTIFDLQNYCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGB0</accession>
    <name>A0A3P9DGB0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Solute carrier family 22 member 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Organic anion transporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Renal organic anion transporter 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Basal cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGB0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033409"/>
    <dbReference type="Ensembl" id="ENSMZET00005034539.1">
        <property type="protein sequence ID" value="ENSMZEP00005033409.1"/>
        <property type="gene ID" value="ENSMZEG00005024941.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165810"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000023">
        <property type="entry name" value="Solute carrier family 22 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="97"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="592" mass="66253" checksum="3FFB6AF5F5389362" modified="2019-02-13" version="1">MGFAELLDEVGGFGRYQWIHVTLISLPGLLMASQNLLNNFVSGVPTHYCSIPANHSLSNLSHLHQVDEKQLLKMFIPPDSSGNRLARCRRYANPQWQLLAANSSTNVSHLETEDCIDGWTFEQSDFLATTVSEWSLVCSLRPLKQMIQTIYMGGVLTGAIVYGSLSDRFGRRSVLIWSYLQLAVLGCSSALSPTYSTYCIFRFLSGMAVSGVIINGVSLKVEWITTKTRTVVGTLSSFFFTFGQMVLAGLAYWLRDWRKLQMVVCAPNFLFFAYSWWYSESARWLVLNQRSEDALKSLHRVARINGKSEMIDKITVEVLHSHMNKEIESARSTFTVFDLLRTPGMRRISICLMAVWFSTSFAYYGLAMDLQKFGVSIYLMQIIFGAVDIPAKLFALGILSYLGRRVSQAVCLFFSAAIIFANIFVPTDMQTLRTTLACLGKAFTSASFTTVYLYTGELYPTVIRQTGMGFVSTMARIGSMAAPAVLILDEVLPALPSLVYGGSAVLAGCFACFLPETLNVPLPDTIEDVEASATHEHTQIKQFSARKQKQQQTTMFTSTKRPVFNLISERISHICDKHLNEHFILEYSDNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHG8</accession>
    <name>A0A3P9DHG8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHG8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033824"/>
    <dbReference type="Ensembl" id="ENSMZET00005035015.1">
        <property type="protein sequence ID" value="ENSMZEP00005033824.1"/>
        <property type="gene ID" value="ENSMZEG00005025294.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164472"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="449" mass="50754" checksum="A1E0DD6EBBCDECD0" modified="2019-02-13" version="1">MGSGSRENIHKMLLSAFLGEGSFGVVTRCRDTKNNKTVAVKVNKSDPEILLQAKLEIFILEQLRRLDPDRCNIVEWNGYFLDGERICLNFELLDQSLSDYIGDRNNRGLPMREIRPILNQLANALFHLGSVGIVHADLKPVNIMVVNRSESQVRVKLIDFGIACNTSAVIPGDCVGTIGYCAPEIMLGTPYDEAIDMWSLGLVAVELATGVPLYPGEDDYDVLKFIIETQGQLPDHLLESGLYTDSYFIEDNHKEQRWTFKTPEQFQYETHYRSKETRSIKLKCLDDLEQLLKVRRGSENGQTLFVRLIKEMLALDANLRITPSEVLKHPFFHPGLSRRTPCTDMNSTGGQNLVLSQQQSSLFQVVLSLSLSLSLTHTHTHTHTHYVTFQQKNTAPSPHTWIHPFMLFMPNSDPAICMSEQKSRLIRPGNIYPIFSCQILRTVASISCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIE0</accession>
    <name>A0A3P9DIE0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="4">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. Involved in somitogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIE0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034159"/>
    <dbReference type="Ensembl" id="ENSMZET00005035357.1">
        <property type="protein sequence ID" value="ENSMZEP00005034159.1"/>
        <property type="gene ID" value="ENSMZEG00005025526.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155297"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10472">
        <property type="entry name" value="EphR_LBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05065">
        <property type="entry name" value="PTKc_EphR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09551">
        <property type="entry name" value="SAM_EPH-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000041">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000015">
        <property type="entry name" value="Ephrin type-B receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000004">
        <property type="entry name" value="Ephrin type-B receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000110">
        <property type="entry name" value="Ephrin type-B receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042819">
        <property type="entry name" value="EphB1_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF17">
        <property type="entry name" value="EPHRIN TYPE-B RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00791">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 26 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0966">Cell projection</keyword>
    <keyword evidence="27" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="18 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11 26 28" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-0675">Receptor</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 30" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="19" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="30">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018253601" description="receptor protein-tyrosine kinase" evidence="30">
        <location>
            <begin position="19"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="34">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="33">
        <location>
            <begin position="323"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="33">
        <location>
            <begin position="434"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="31">
        <location>
            <begin position="642"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="32">
        <location>
            <begin position="934"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="25">
        <location>
            <position position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <begin position="648"/>
            <end position="656"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26 28">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="27">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="27">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00055965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112283" checksum="2B9D27980834C7EC" modified="2019-02-13" version="1">MTVDLFALLCVLVITSSAMEETLMDTRVATAELGWTAYPNSGWEEVSGYDENLNTIRTYQVCNVFEPSQNNWLLTTFIDRRGAQRIYVEIRFTVRDCSSIPNVPGSCKETFNLYYYENDAVIATKGTVFWMEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLSKNGFYLAFQDYGACMSLLSVRVFYKKCPSVVQNFAVFPETMTGAESTSLVIARGTCIANSEEVDVPIKLYCNGDGEWMVPIGSCTCKAGFEPDNGNVCRACPPGTFKSTQGPSLCLQCPPNSRSTSEAATICVCRNGYYRGDGDQPDKPCTSVPSSPRNVISIVNETSVILEWHAPRETGGRDDVVYNIVCKKCQANRRSCSHCDDNVEFVPRQLGLTETRVFISNLLAHTVYSFEIQAVNGVSNKSPYPAQHVSIDITTNQAAPSIVPIMHQISSTMNSFTLSWPQPEQPNGIILDYELRYYEKDHAEINSTILRSQTNTARVEALRPGTVYVVQVRARTVAGFGKYSSKMCFQTLTDDDFKSELREQLPLIAGSAAAGVVFIVSLIAISIVCSRKRAYSKEAVYSDKLQHYTTGRELSLRADMSNCPSPLGCPTHFSGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSTVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYVEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEFMENGALDSFLRQNDGQFTVIQLVGMMRGISAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPSYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNVRPRFTDIVSTLDKMIRNPASLKAVANIPAVPSQPLLDRSIPDVNTFSSVEDWLAAIKMSQYRDNFLNSGFTSLQLVAQMTSEDLLRIGVTLAGHQKKILTNIQSMRVQMSQSSTPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIK2</accession>
    <name>A0A3P9DIK2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004542571.1">
        <property type="nucleotide sequence ID" value="XM_004542514.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIK2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034238"/>
    <dbReference type="Ensembl" id="ENSMZET00005035440.1">
        <property type="protein sequence ID" value="ENSMZEP00005034238.1"/>
        <property type="gene ID" value="ENSMZEG00005025594.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487890"/>
    <dbReference type="KEGG" id="mze:101487890"/>
    <dbReference type="CTD" id="55658"/>
    <dbReference type="GeneTree" id="ENSGT00940000157113"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000069">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF21">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="311" mass="34584" checksum="215A24B5758ACC01" modified="2019-02-13" version="1">MAEAPPRPCRFFCHRCSAEISPRLPDYTCPRCESGFIEELPEERSAENGSASTSSSSDQFRPVLENVDHQHLFTFPPGYGPFALGIFDENFDLRLRLPTEDNRETENRREREMASRQRYGARQPRGRHVPRRQGTRHEGVPTLEGIIQQLVNGIIAPTAMPNIGMGPWGMLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADRERIKNLPTISITEEHVSAGLECPVCKEDYSVDESVRQLPCNHLFHNDCIVPWLEQHDTCPVCRKSLSGQNTATDPPGLSRMNFSPSSSSSSSPSSPSNENAASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK47</accession>
    <name>A0A3P9DK47_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DK47"/>
    <dbReference type="Ensembl" id="ENSMZET00005035743.1">
        <property type="protein sequence ID" value="ENSMZEP00005034531.1"/>
        <property type="gene ID" value="ENSMZEG00005025795.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177148"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039051">
        <property type="entry name" value="SE-CTX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40472:SF8">
        <property type="entry name" value="RAPUNZEL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40472">
        <property type="entry name" value="RICIN B-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018136784" description="EGF-like domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="551" mass="62708" checksum="5A14BD6B1EF94199" modified="2019-02-13" version="1">MASVGPLLLLMMSAFFIISSVTTSRSADQSKHKKPLLEKLKQGNEKLKSALKNKENLKNIGELCLTLITGIGDALKDTSHDILKSAASVASVVPVVGAVFSLLMTIAILIDEHVNDKSLLKDIKEEFEKIDLKLEKHHRELKWNIWAAATYSKPEMKIRTAWTEYKTLLGSLAGAKDQDERKRHEKSFIEAYSKYEKAPREMGELLKKTGKSFVNNLGDELAEYVKCHEKEIIEYTYLILTLIFKGNMMNQFYYRLKNIQSEARNDEMKKNVYEAMTAMFEIQKQCIDSSMTYVKQDVKPLIDKSKKRDDLAQEVWDFLQKTYDRYDWMVVGFITKKSRHKTIKTLNKHVLTGFQDVSTERITVAVSRQVKGTQSKVQEVSTAIEKCIKKKVLCYKVEETLRTCGEKVAGIPMSQTYTEGNRKANVKDQADDEDEVSAAPENPSDQTPYIYTGEYPCAKQDCGQRKGRGKCVKMKDMFLGICQCNYPYYGLHCENDINDYAIELEKEAGTQKNKPTVTGKRSASICLDHMFVADVLTVTKTKWALIGLNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DL16</accession>
    <name>A0A3P9DL16_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein phosphatase 1 regulatory subunit 9B</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DL16"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035043"/>
    <dbReference type="Ensembl" id="ENSMZET00005036289.1">
        <property type="protein sequence ID" value="ENSMZEP00005035043.1"/>
        <property type="gene ID" value="ENSMZEG00005026210.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158833"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06790">
        <property type="entry name" value="PDZ_neurabin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000010">
        <property type="entry name" value="Neurabin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040645">
        <property type="entry name" value="Neurabin-1/2_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043446">
        <property type="entry name" value="Neurabin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154">
        <property type="entry name" value="NEURABIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154:SF24">
        <property type="entry name" value="NEURABIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17817">
        <property type="entry name" value="PDZ_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="14">
        <location>
            <begin position="435"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="710"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="605"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="740" mass="82677" checksum="02FAE92CB8C49B36" modified="2019-02-13" version="1">MYQKSCLSDSIQPRGPFSNLRSPSPHRNAYEAGADPASKPAPLPRPTGRGRKYGSNVHRIKNMFMQMQSPGDEEDGAKMIGKEQAVKLSLPRVSSLNEHVDHSALLKLGGTVSERVNRFDSKVGREGSGSSVGLSKLQETRRIFEQRTLQQAATNRILLKKERASGFQDSRLDVVARFNGSTEALDRLDDPPAVSPTVSQLSAAFEKGDLQNNLYLPQRRSAPALAPKPKPPPRVEAAKPEPAATEAKGSSTVEASGLQPQSGDQDSATAGSEAAGRLVQAEVHASLENGEKEPPSSSPSSEEKEEDSEERAKEDENDEDGSRKEDYSEGDLIDISAYSGLGEEDSGGSQLDDEDDEDEEEAYQPESSCSEIPGLPEEEEPPPPSRKIRFSTQPIRVFTTYSNEDYDRRNDDVDPMAASAEYELEKRVEKLDLFPVELEKDSDGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAQRDGRIQVNDLIVEVDGTSLVGVTQSFAATVLRNTTGKVCDWPGEAGEQSEVAQLIQQTLEQERWQREMMEQRYKQYMDDDEETGEYATDEEEEMSPMFPNSIEVFDLAENQEMLSPVELDPEKLAHKFKELQIKHAVTQAEIQLLKRKLAHAEQDKLRWRMERAQLEQNIRDSKERMEKLEGYWMEAQSLCKAVDEHLKETQAQYQTLERKYSKAKRLIKEYQQKEIEYLKKETAQRRAQEESEATHKEETDNLQEKVRSGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DN80</accession>
    <name>A0A3P9DN80_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Zinc fingers and homeoboxes protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZHX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574988.2">
        <property type="nucleotide sequence ID" value="XM_004574931.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004574990.2">
        <property type="nucleotide sequence ID" value="XM_004574933.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004574991.2">
        <property type="nucleotide sequence ID" value="XM_004574934.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004574992.2">
        <property type="nucleotide sequence ID" value="XM_004574935.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004574993.2">
        <property type="nucleotide sequence ID" value="XM_004574936.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012771419.2">
        <property type="nucleotide sequence ID" value="XM_012915965.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024654254.1">
        <property type="nucleotide sequence ID" value="XM_024798486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DN80"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036255"/>
    <dbReference type="Ensembl" id="ENSMZET00005037529.1">
        <property type="protein sequence ID" value="ENSMZEP00005036255.1"/>
        <property type="gene ID" value="ENSMZEG00005027046.1"/>
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    <dbReference type="Ensembl" id="ENSMZET00005037531.1">
        <property type="protein sequence ID" value="ENSMZEP00005036257.1"/>
        <property type="gene ID" value="ENSMZEG00005027046.1"/>
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    <dbReference type="KEGG" id="mze:101470116"/>
    <dbReference type="GeneTree" id="ENSGT00950000182893"/>
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        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000296">
        <property type="entry name" value="Zinc fingers and homeoboxes protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000062">
        <property type="entry name" value="zinc fingers and homeoboxes protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR041057">
        <property type="entry name" value="ZHX_Znf_C2H2"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15467:SF5">
        <property type="entry name" value="ZINC FINGERS AND HOMEOBOXES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15467">
        <property type="entry name" value="ZINC-FINGERS AND HOMEOBOXES RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18387">
        <property type="entry name" value="zf_C2H2_ZHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13 17 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 17 18" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 17 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="20">
        <location>
            <begin position="311"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="20">
        <location>
            <begin position="725"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="20">
        <location>
            <begin position="858"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="17">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="17">
        <location>
            <begin position="727"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="17">
        <location>
            <begin position="860"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
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            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
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            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="468"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007440"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022491"/>
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            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="1038" mass="113549" checksum="10ADC5C8D56645BD" modified="2019-02-13" version="1">MSSRRKSSTPCMVRVISDLPDEQDDPEEVMDMEILASKDVRENEPPESAKKSQNLMKDNGDNPDRKAFPKHLDKEQQSGCEDHPPVIEDVEARGGKDKEAPESDPVSQKKQGRGYECKYCPFSTQNLNDFKEHVDSSHPNVILNPLYLCAVCNFNTKKFDSLTEHNESRHPGETNFKFKRIKMNNQTILEQTIEGKDNSAECDVTNEKGESHSSSVFSPCISTTVKSPGSVHTLFGGSELKSQLDGLIQKDQITAVNINGTVIIPEPTIVQGLSHVTPMLQRPPNFNSVPKIAVPLNTTKYNPSLDNNLTLIASFNKFPYPTHAELSWLTAASKHPEEQIKVWFTTQRLKQGITWSPEEVEEARKKMFNGSIPPAHHTFTVLPTSPISQPSAKASQQPIVHTTVEHLGHVRTTAPNGLTVVTTNSPAGSSHSLKRPLPTQLSTVFESKRPIMAVAPHSGDPKDKVLMAPPPPPPPPKGRLPMAPPLVPVEMKRPVAVPLVTTEMKRSSAAVPLMPPPPSLSSSSLSSKGKILSASGNPKTKPVVSLPSIVFPESLTRPMIAPPPISVSPFRNSLLIPRTVPVPSKEKHPSSHNLPASDLNLPNSPPLITSQVRRPTIIQSIRAPAKAPSQISAFSLDGKKLKEQQGVELKASYPRGDKVVSPLPEANGTSRMDGKWPFDQTSPGHNNGILHLDGGDIPAVPKPDFQHKSSVLTQFPLLERMKGKTAKQLKILEENFLRNSFPTHSDVDNLSAITRLSHQEIDSWFAERRALRDNLEQALLNSMGTKRMGGNGIGAITEKQLHQHQALQLNGIHKPSTGVGLLKSPPPTSHPLSMIAPGTIAPSVPNLNSCSVPPDGRSLALLKDDFAQTRWPSPEEFSQLEGRTGLAPGELARWFTDSRLQSGSMDLAELFHNNGVNGGQGLPMCSPENIPPSIIQRCQEGAVTNNNSKVLEVEMGWLMDQRTNSLNNQQHDELQDQFAGRLRQQSVAELKNGGQNGGVLGGVREVFGTWLEDSRRGRELLVDREKKMAEDASGRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ57</accession>
    <name>A0A3P9DQ57_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lysophosphatidic acid receptor 6-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004562848.1">
        <property type="nucleotide sequence ID" value="XM_004562791.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMZET00005038180.1">
        <property type="protein sequence ID" value="ENSMZEP00005036890.1"/>
        <property type="gene ID" value="ENSMZEG00005027492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464256"/>
    <dbReference type="KEGG" id="mze:101464256"/>
    <dbReference type="GeneTree" id="ENSGT00950000183136"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070915">
        <property type="term" value="F:lysophosphatidic acid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14982">
        <property type="entry name" value="7tmA_purinoceptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF90">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID RECEPTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="282" mass="31818" checksum="96F737651A880F49" modified="2019-02-13" version="1">MNTSNSSTEDDRVYAGIFGCIMVIGLPLNAVSLWILLRRHSLKSPNAVFMVNLALSDLLAIFSLPMRIYHHATGTPLGIITCLFSVIIFRNNIRSSASFITFISVDRLLAVVYPLRSRHLRTSCNAWKGAALVWGVLLVVNIPEAKGFLEHLQNHTDHICFELHEYKSVTRSAIIYLQIVLLVTMLAVNIVCTVMVSWTLHKHLSDSAKVRNKVNVMLIFAINLLIFCTCFLPMPLHILTKSKTSITPLACLIVLSCCLDPLMYYFSFDSFWKKKEDTGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQI5</accession>
    <name>A0A3P9DQI5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin-lysine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.60</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the trimethylation of 'Lys-116' in calmodulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21556"/>
            <dbReference type="Rhea" id="RHEA-COMP:11360"/>
            <dbReference type="Rhea" id="RHEA-COMP:11361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.60"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.60" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004570145.2">
        <property type="nucleotide sequence ID" value="XM_004570088.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004570146.2">
        <property type="nucleotide sequence ID" value="XM_004570089.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004570147.2">
        <property type="nucleotide sequence ID" value="XM_004570090.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004570148.2">
        <property type="nucleotide sequence ID" value="XM_004570091.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012779816.2">
        <property type="nucleotide sequence ID" value="XM_012924362.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQI5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036714"/>
    <dbReference type="Ensembl" id="ENSMZET00005038001.1">
        <property type="protein sequence ID" value="ENSMZEP00005036714.1"/>
        <property type="gene ID" value="ENSMZEG00005027373.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002168"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018025">
        <property type="term" value="F:calmodulin-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000140">
        <property type="entry name" value="Calmodulin-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025800">
        <property type="entry name" value="CaM-Lys-N-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539:SF3">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020594"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051756"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="339" mass="38436" checksum="8C25725447F6E8EF" modified="2019-02-13" version="1">MDRDSSGAAERTEPASPLGKNIHEDTRAADSRASRSGTCRNTDVARARWTLLRQVLRQKQVESPEVKQVSVRRFATFDLFSRKRLVARDHSDTSDDQWVEYRSVYFPEYSALLRDNMGPLRVNEVLNSFDNTGNVCVWPSEEVMAHYCLQKRHMFKGAVCELGGGMTCLGGLMVAICADVTEVLLSDGNEKSIQNVRGLVEKNRQAGKFDSTYVSSRVVRWDCEMDISALEGHFDFIMCADCLFLDQYRASLVDAIRRLLQPSGMALVFAPQRGETLRLFCQLAQQAGFCISQHQQYDAQVWDVHLKMLREGKEVYDENIHYPHLITLTKGPQPVSLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRE8</accession>
    <name>A0A3P9DRE8_9CICH</name>
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        <recommendedName>
            <fullName evidence="21">Exosome complex exonuclease RRP44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Protein DIS3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the RNA exosome complex; within the complex interacts with EXOSC4, EXOSC7 and EXOSC9 of the exosome core complex (Exo-9). The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3; DIS3 associates with the base ring of Exo-9. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with DHX34; the interaction is RNA-independent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 24">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551551.1">
        <property type="nucleotide sequence ID" value="XM_004551494.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRE8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036817"/>
    <dbReference type="Ensembl" id="ENSMZET00005038106.1">
        <property type="protein sequence ID" value="ENSMZEP00005036817.1"/>
        <property type="gene ID" value="ENSMZEG00005027441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470510"/>
    <dbReference type="KEGG" id="mze:101470510"/>
    <dbReference type="CTD" id="22894"/>
    <dbReference type="GeneTree" id="ENSGT00530000063106"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000125">
        <property type="entry name" value="exosome complex exonuclease RRP44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000002">
        <property type="entry name" value="exosome complex exonuclease RRP44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="13" id="KW-0271">Exosome</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="25">
        <location>
            <begin position="61"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="26">
        <location>
            <begin position="464"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="950" mass="107489" checksum="DC05D4B3EB71514B" modified="2019-02-13" version="1">MLKSKTFVKKTRSGGVMKVVREHYLRDDIWCGSEVCTECKQESTVLQKDACMESSLCSYPHYLVPDTNVVLHQIDILEDPVICNVIILQTVLQEVRHRSAPVYKRLKDIIHEKEKRFYTFTNEHHRDTFIEREPGESANDRNDRAIRVAVKWYSQHLKTFESDTDGLKVVLLTNDQGNKQKAQDNGLLVYKCEEYVKSLIANPELVDRLALSSDDKNEITSSKVLFPEHLPLSRIQTGIKSSSFLQGTFRASRDNYLEATVFVQGEGEDSTEVLIQGLQNLNRAVHQDVVAVQLLPRSEWVAPSSVVLQDEGTAKDDEDAEEEEGKLRTAAVEAARKPTGKVVGIIKRNWRPFCGMLNVSQIKESTRHLFTPADRRIPRIRIETRQASTLSGQRIMVAIDGWPKDSRYPNGHFVRSLGGAGEKDTEEEVLLLEHDVPHQAFSQAVLSFLPKMPWAITPEDMMKREDLRPLTVCSVDPPGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDKEAANRGTTVYLCGKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEINHKAEILKTRFTKSVINSKASLTYAEAQMRIDDTNKNDDITKSLRGLNKLAKILKRQRIEKGALTLSSLEVRFHMDSETHDPIDLQTKELMETNSMVEEFMLLANISVAQKIYDEFSECALLRKHPAPPPSNYDILIKAAKSKEVKIHTDSAKALADSLDAAKVDGFPYFNTLLRILATRCMMQAVYFCSGMDSDFHHYGLASPIYTHFTSPIRRYADIIVHRLLAVAIGADTTYPDLMDKHKQSALCNNLNYRHKMSQYAQRASVAFHTQLFFKSRGILNEEGFVLFVRKNAIIVLIPKFGLEGTVFFDSKDKVSPNIVFEEEGPTLSVEQHKFHIFDKVKVTISLDDSNIQHQKIRMALIEPVIPGVSVPAPDTERPAKKQKLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DV29</accession>
    <name>A0A3P9DV29_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lysosomal amino acid transporter 1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">PQ-loop repeat-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Solute carrier family 66 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004575453.1">
        <property type="nucleotide sequence ID" value="XM_004575396.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004575454.1">
        <property type="nucleotide sequence ID" value="XM_004575397.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004575455.1">
        <property type="nucleotide sequence ID" value="XM_004575398.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DV29"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005038086"/>
    <dbReference type="Ensembl" id="ENSMZET00005039488.1">
        <property type="protein sequence ID" value="ENSMZEP00005038086.1"/>
        <property type="gene ID" value="ENSMZEG00005028484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475446"/>
    <dbReference type="KEGG" id="mze:101475446"/>
    <dbReference type="CTD" id="54896"/>
    <dbReference type="GeneTree" id="ENSGT00390000003344"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080144">
        <property type="term" value="P:intracellular amino acid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000013">
        <property type="entry name" value="lysosomal amino acid transporter 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000017">
        <property type="entry name" value="lysosomal amino acid transporter 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF36">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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            <begin position="140"/>
            <end position="159"/>
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            <end position="210"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004155"/>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="309" mass="34223" checksum="9D2DDC04E019B4B0" modified="2019-02-13" version="1">MSTDGVLTRATLGWTTSENFTSLCPNGSKWVWEGLGECAQDARDMASVYLGLLSILCFLVSSFPQYYNSWKSGNMDQALSIWFLLLWLGGDSCNLIGSFLADQLPLQQYTAIYYVAADLIMLSMYTYYKLKNKASQGRTRLLVVGVSCFLCFATSLTQLPDVGPHKEIISSGFRSRSLLSTSSTSSITPFTTKEIIGFCIGSVSSVLYLCSRGPQIYTNFKRKSTQGVSYFLFALVILGNTTYGLSVLLKNPDLGQGESSYMIHHVPWLIGSLGTLSLDLIISVQFLMYRNARPRVEVNHDETAPLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AQV3</accession>
    <name>A0A3P9AQV3_9CICH</name>
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        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 7A1, mitochondrial</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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    </organism>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="13" key="2">
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="3">Belongs to the cytochrome c oxidase VIIa family.</text>
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        <property type="gene ID" value="ENSMZEG00005000081.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486557"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154550"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitochondrial respirasome assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxidase_su7a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003177">
        <property type="entry name" value="Cytc_oxidase_su7a_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10510">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10510:SF5">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81419">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000046.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="81" mass="9079" checksum="37EA145B3C958759" modified="2019-02-13" version="1">MNHLVKLPRLASRAFSSSARQLKNKVPESQKIFQEDNGLPVHIKGGTGDVLLYRATMTLTIAGTCYSLYWLLIASFPQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AR13</accession>
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        <submittedName>
            <fullName evidence="12">FAM20C golgi associated secretory pathway kinase</fullName>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AR13"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000129"/>
    <dbReference type="Ensembl" id="ENSMZET00005000169.1">
        <property type="protein sequence ID" value="ENSMZEP00005000129.1"/>
        <property type="gene ID" value="ENSMZEG00005000106.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182951"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070166">
        <property type="term" value="P:enamel mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF11">
        <property type="entry name" value="EXTRACELLULAR SERINE_THREONINE PROTEIN KINASE FAM20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAM20 C-terminal" evidence="11">
        <location>
            <begin position="325"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="559" mass="64495" checksum="1A703BD6D86B7035" modified="2019-02-13" version="1">LNMILFRKFRVLILMVFLVACTMHIMIDLLPKLEKRATGAESGDGGCQCAHHTAGSPGWPNKHTLRILQDFSNEPSSNLTSHSLEKITTAGDRADSFRRMKTSAGKADDHKPLMGDASGGRIVPSRAVSRLSRLFEHPLYKVELPPLTDDDTLFNVNNDIRFYPRATGNQGWHNEDGNEDEEEFSPTEEVTAESYPNWLRFHIGINRYELYSRHSPVLDALLKDLVTQRITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDFERHNAEIAAFHLDRILDFRRVPPVAGRLVNMTREIRDLTRDKKLWRTFFISPANNVCFYGECSYYCSTEHALCGKPDQIEGSLAAFLPDLNLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCDEVKQTPPYDRGTRLLDIMDMTIFDFLMGNMDRHHYETFEKFGNDTFIIHLDNGRGFGKHSHDELSILVPLSQCCRMRKSTYLRLQLLAKEEYQLSSMMEESLLRDRLSPILIQPHLQAMDRRLRLVLQVVAGCIEKEGYVNVVEEDLVGDTATHRGPGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARH4</accession>
    <name>A0A3P9ARH4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfotransferase</fullName>
            <ecNumber evidence="6">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARH4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000037"/>
    <dbReference type="Ensembl" id="ENSMZET00005000065.1">
        <property type="protein sequence ID" value="ENSMZEP00005000037.1"/>
        <property type="gene ID" value="ENSMZEG00005000074.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163342"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="7">
        <location>
            <begin position="99"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="355" mass="41461" checksum="1D1457CD4C947AA9" modified="2019-02-13" version="1">MLPTKGSGSQGRAGISFLPWEGPSHCSVLRNQKLHIKYSSGQRKIPVRETRQKPAISMSLDPEKAVFPSRQQLFDFHGVSMIPIFTTNWENVQNFQARPDDILIATYPKAGTTWVSQILDLLYFGQTERQKTIPIFERVPFLEIAVPPLFSGKDLADKLPTTPRLIKTHFPVQFVPKSFWEQNCKIVYVARNAKDNMVSFFHFDRMNIAHPEPGDWSNYIHRFMEGKMVFGSWYDHVNGWWKKKQTYSNIHYMFYEDMIEDTEREIDKLCSFLSLSNSAEDKKMIAGGVQFDNMKKNEMTNYSTFSILDFKISPFMRKGKVADWKNHFTVAQNEVFDEDYKKKMKDPTLQFRTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AS67</accession>
    <name>A0A3P9AS67_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">17S U2 SnRNP complex component HTATSF1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins. Within the 17S U2 SnRNP complex, interacts (via UHM region) directly with SF3B1. Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with TCERG1/CA150. Interacts with (poly-ADP-ribosylated) RPA1; promoting HTATSF1 recruitment to DNA damage sites. Interacts (when phosphorylated) with TOPBP1; promoting recruitment of TOPBP1 to DNA damage sites during S-phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTATSF1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004550262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AS67"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000544"/>
    <dbReference type="Ensembl" id="ENSMZET00005000609.1">
        <property type="protein sequence ID" value="ENSMZEP00005000544.1"/>
        <property type="gene ID" value="ENSMZEG00005000485.1"/>
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    <dbReference type="GeneID" id="101485057"/>
    <dbReference type="KEGG" id="mze:101485057"/>
    <dbReference type="CTD" id="27336"/>
    <dbReference type="GeneTree" id="ENSGT00390000009902"/>
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        <property type="component" value="LG10"/>
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    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12282">
        <property type="entry name" value="RRM2_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000202">
        <property type="entry name" value="HIV Tat-specific factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 22" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="24">
        <location>
            <begin position="148"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="24">
        <location>
            <begin position="278"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="385"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00062124"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="452" mass="51578" checksum="E04D55183D5FDA94" modified="2019-02-13" version="1">MSGKSDPNKEFMEQLRLQELYDQRNEDGSDPYTYTDPEDGTVYDWDHEKKAWFPKITEDFMAAYQANYGFTEKSAPDGKNASLTSTNPAAPGPDSKPPQKPTEKEKPEDPAPNSASEQHETPGKETKQKGEKRKAEQGWFDIDENKNTNVYVSGLPPDISSEEFAELMSKCGIVMRDPITEEYKVKLYKDKEGNLKGDGLCCYLKKESVDLAIRLIDESEVRGYKLHVEAARFELKGQYDASKKKKKSKDYKKKLQQQQKQLDWRPEKKGDARKRHEKVVIIRNMFHPSDFEEDPLVLNEYREDLRSECEKFGEVKKVILFDRHPDGVASVAFKEPEEADACILSFNGRWFGGRQLSAQLWDGTTDYQVEETTREREERLKGWSQFLEGGEGEQQKDSKPAESSTATEPSEPSSTTEPEQQPKSEPQSSEEQQEEEVDSTDSSLAGSEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AS84</accession>
    <name>A0A3P9AS84_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AS84"/>
    <dbReference type="Ensembl" id="ENSMZET00005000601.1">
        <property type="protein sequence ID" value="ENSMZEP00005000536.1"/>
        <property type="gene ID" value="ENSMZEG00005000507.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01080000257344"/>
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        <property type="component" value="LG22"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
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    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
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    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07686">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="114" mass="12448" checksum="C9E7EB0E6802295A" modified="2025-10-08" version="2">MAWVMVPLSNSWRALTQPGAVSSAVGGSVSIKCRTSQNVHDNNLLAWYQQKDGGVPKLLIYYTSSRYSGIPDRFTGSGSNSDFTLTISGVQAEDAAVYYCQSYHIINSQSVFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASZ5</accession>
    <name>A0A3P9ASZ5_9CICH</name>
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            <fullName evidence="2">Outer dense fiber of sperm tails 3-like 2a</fullName>
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        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Haplochromini</taxon>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014269787.1">
        <property type="nucleotide sequence ID" value="XM_014414301.1"/>
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        <property type="gene ID" value="ENSMZEG00005000732.1"/>
    </dbReference>
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        <property type="component" value="LG19"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="OUTER DENSE FIBER OF SPERM TAILS 3-LIKE 2-RELATED"/>
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            <begin position="1"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="254" mass="27792" checksum="49F42B477C7FC22B" modified="2019-02-13" version="1">MEEAEKKRPIISARERGPGPGRYSLPPTVGYINHDFTKPRSAAYTFHSRMSSAMVSVDSSPGPRYHVGSKVTRFGSMETPSYSILGRGGRTGSDLFQTPGPGAYSPEKAPPLNGHRRPPSHIIGARTRYRSVDAVPSPNSYSLPNLLGHHIPHKPSSASYSFSARRKVGAPSEDLATTPGPGKYNSTNPDIYRHRHPSFTMQGRTKRPNYSSAIPGPGAYSPERFHLHLPRPPSFTLGIRHSEFVTPLVVNVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AY72</accession>
    <name>A0A3P9AY72_9CICH</name>
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        <recommendedName>
            <fullName evidence="12">Histone H4</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
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        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Johnson J."/>
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                <person name="Eshel O."/>
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                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
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                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
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                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
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    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="CENP-T/H4_C"/>
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        <property type="entry name" value="Histone-fold"/>
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        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
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    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
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    <dbReference type="PRINTS" id="PR00623">
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    <keyword evidence="5 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
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    <keyword evidence="11" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 12" id="KW-0544">Nucleosome core</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="14">
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        <source>
            <dbReference type="RuleBase" id="RU000528"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002594.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="104" mass="11487" checksum="E6E0A2FC81B1C38E" modified="2019-02-13" version="1">MSGQGKKGGKGLGKGGAKRRRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYR2</accession>
    <name>A0A3P9AYR2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein ILRUN</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004547577.1">
        <property type="nucleotide sequence ID" value="XM_004547520.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYR2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002836"/>
    <dbReference type="Ensembl" id="ENSMZET00005002952.1">
        <property type="protein sequence ID" value="ENSMZEP00005002836.1"/>
        <property type="gene ID" value="ENSMZEG00005002206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479521"/>
    <dbReference type="KEGG" id="mze:101479521"/>
    <dbReference type="CTD" id="64771"/>
    <dbReference type="GeneTree" id="ENSGT00490000043415"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14349">
        <property type="entry name" value="UBA_CF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000015">
        <property type="entry name" value="Chromosome 6 C6orf106 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000289">
        <property type="entry name" value="Chromosome 6 open reading frame 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039517">
        <property type="entry name" value="C6orf106_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nbr1 FW" evidence="9">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="280" mass="30881" checksum="8938A741C34F834C" modified="2019-02-13" version="1">MEGTDMDVDAELMQKFSCMGTTDKDVLISEFQRLLGFQLNPAGCAFFLDMTNWNLQAAIGAYYDFESPNVNTPSMSFVEDVTIGEGESVPPDTLFTKTWRIQNTGAESWPPGVCLKYIGGDQFGHVNTVIVKSLDPQEISDVSVQMRSPTTPGMYQGQWRMCTATGLFYGDVIWVILSVEVGGLLGVTQQLSSFETEFNTQPQRNVQGDFNPFASPQKNKHDATDNSFRDPGGAWERTQEPIQQDQNGLSHNAVNRASNGLQTNLSVVTYGQGPYPFGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZ40</accession>
    <name>A0A3P9AZ40_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ubiquitin carboxyl-terminal hydrolase 13</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Deubiquitinating enzyme 13</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin thioesterase 13</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquitin-specific-processing protease 13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_012779850.1">
        <property type="nucleotide sequence ID" value="XM_012924396.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012779851.1">
        <property type="nucleotide sequence ID" value="XM_012924397.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZ40"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002874"/>
    <dbReference type="Ensembl" id="ENSMZET00005002990.1">
        <property type="protein sequence ID" value="ENSMZEP00005002874.1"/>
        <property type="gene ID" value="ENSMZEG00005002200.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482101"/>
    <dbReference type="KEGG" id="mze:101482101"/>
    <dbReference type="CTD" id="8975"/>
    <dbReference type="GeneTree" id="ENSGT00940000157401"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14384">
        <property type="entry name" value="UBA1_UBP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000016">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000026">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000770">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000063">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
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                <person name="Nishihara H."/>
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                <person name="Przybylski D."/>
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                <person name="Sanchez-Pulido L."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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    <sequence length="173" mass="19007" checksum="F8E63597E96F1611" modified="2019-02-13" version="1">MNGYNFTDFNSTHEAHAYPYSASVDDPLYRQYKPPVKELIPLPKAVLYLLMAALVVVGVAYAIIGHLIKDLAIDITCLLGPPGDEDKDEDDPQRMGSHPPSAHPFAHNAFHVWDQDDVVIPLSRDESPQTSPLLLAAIPYIPSFFPHSHSPPSHGSPGFPNCPETSKEIPGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZF7</accession>
    <name>A0A3P9AZF7_9CICH</name>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZF7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003060"/>
    <dbReference type="Ensembl" id="ENSMZET00005003185.1">
        <property type="protein sequence ID" value="ENSMZEP00005003060.1"/>
        <property type="gene ID" value="ENSMZEG00005002353.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158952"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004963">
        <property type="term" value="F:follicle-stimulating hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004996">
        <property type="term" value="F:thyroid-stimulating hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000223">
        <property type="entry name" value="Thyrotropin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000496">
        <property type="entry name" value="Thyrotropin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002274">
        <property type="entry name" value="TSH_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF5">
        <property type="entry name" value="FOLLICLE-STIMULATING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01145">
        <property type="entry name" value="TSHRECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017853690" description="Thyrotropin receptor" evidence="12">
        <location>
            <begin position="20"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="388"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="700" mass="77968" checksum="B6D348B3B97490D7" modified="2019-02-13" version="1">MLVMTLMMLLIVTIKTAAASARGSEMDIRPGFHPSLAKQTSCPSCQVMFGVTAFPSNISSAQCLEVKQTQIREIQQGAFSSLQHLMELTISENDMLESFGAFAFSGLPQLTKILISKNAALRNIGAFAFSDLPELSEIIITKSKHLSSIHPDAFRNMARLRFLTISNTGLRIFPDFSKIHSTACFLLDLQDNSHIKRVPANAFRGLCTQTIAEIRLTRNGIKEVASDAFNGTKMHRLFLRGNRQLTHISPSAFVGSSELVVLDISETALASLPDSILGGLKRLIAESAFNLKELPPLQLFTKLRQAKLTYPSHCCAFLNMHRNRSGWHSLCDNPEAKNNLHFFREHCSNSTSITCSPAPDDFNPCEDIMSAAPLRILIWIISVLALLGNTVVLLVLLGSRYKLTVPRFLMCHLAFADLCMGIYLVVIATVDMLTRGRYYNYAIDWQMGLGCNAAGFFTVFASELSVFTLTAITVERWHTITHALRLDRKLRLRHACIIMTIGWIFSLLAALLPTVGISSYGKVSICLPMDVESLVSQFYVVCLLLLNILAFFCVCGCYLSIYLTFRKPSSAPAHADTRVAQRMAVLIFTDFICMAPISFFAISAALKLPLITVSDSKLLLVLFYPINSCSNPFLYAFFTRNFRRDFFLLAARFGLFKTRAQIYRTESSSCQQPAWTSPKNSRVILYSLANTLSLDGKQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZN2</accession>
    <name>A0A3P9AZN2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.</text>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DIPP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004547584.1">
        <property type="nucleotide sequence ID" value="XM_004547527.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZN2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002932"/>
    <dbReference type="Ensembl" id="ENSMZET00005003048.1">
        <property type="protein sequence ID" value="ENSMZEP00005002932.1"/>
        <property type="gene ID" value="ENSMZEG00005002284.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481241"/>
    <dbReference type="KEGG" id="mze:101481241"/>
    <dbReference type="CTD" id="450013"/>
    <dbReference type="GeneTree" id="ENSGT00940000157882"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="diphosphoinositol polyphosphate phosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
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    <dbReference type="InterPro" id="IPR015797">
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    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF5">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008266"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="178" mass="19945" checksum="2EAED6F4213F2ABB" modified="2019-02-13" version="1">MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDKWIVPGGGMEPEEEPNVAAAREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIDDAIQVLQCHKPVQATYFEALQESCLTSNGTPLVTTIGGDLSPTYSINQSSVSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0D2</accession>
    <name>A0A3P9B0D2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004572542.3"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005003383"/>
    <dbReference type="Ensembl" id="ENSMZET00005003515.1">
        <property type="protein sequence ID" value="ENSMZEP00005003383.1"/>
        <property type="gene ID" value="ENSMZEG00005002613.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101482894"/>
    <dbReference type="CTD" id="100000797"/>
    <dbReference type="GeneTree" id="ENSGT00890000139453"/>
    <dbReference type="OrthoDB" id="9832999at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NYAP1/NYAP2"/>
    </dbReference>
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        <property type="entry name" value="NYAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039482">
        <property type="entry name" value="NYAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22633:SF1">
        <property type="entry name" value="NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22633">
        <property type="entry name" value="NEURONAL TYROSINE-PHOSPHORYLATED PHOSPHOINOSITIDE-3-KINASE ADAPTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NYAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter C-terminal" evidence="4">
        <location>
            <begin position="527"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="349"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
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        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
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        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
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        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF15439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15452"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="665" mass="72974" checksum="225F7F8581F37247" modified="2019-02-13" version="1">MTSQEEGSSFRRFFQYVEDSGLRIYDGLVIQNASDIARESDRIRNQTNWTYLHEKHQKKRRQEESIKRIGEDVAAASDGAYSGKHFRMGFMTMPAPQDRLPPANQGFTVRSQSLHSVGGGEDDSSSSRKQPPPKPKRDPNTKLSSSSETVDGGGVTRRDHQDTKEKLEQAEAQCFLHSEDASKKMPPPKPKRNPNTQLSTSFDECYIRNHGNKKSSLQWDKSSSQSQSPASRDTDEEEPVYIEMVGNILRGLKGQEAEEDDQNESVYEEMKYPMLEDFLQDTNAAIIDPEAWSSRGSLCDIPPPFPNLLTHRPPLLIFPPAPAQCSPNSDESPLTPLDVTRLPMLENVSYSKSGSVEQPQSSTHYRKERDRDMPSTHTITSSGRSSAPPLPSSLYKSSSTTHGGHGYPRSQSACPSPVSMGRSLTPLSLKRPPPYDTLMAGGSMPRSSSSSSSSSHRAGEGGAKLSNSSSTHGSMQNMSVRSQTPTSPLDELNNLFASGRQVMKRGSGGRKSREGEGDGKSRHDSKDRDGQSSPVSSRMGRSSVSPTMMLTGGGEPKSAGKLGRSASTSGVPSPGGMPHRHLHEPHHLALSQMPWLCGDATMMEMIEKKRVLCREIKARQRPDKNLCKQDSMPILPSWKRKQPPPYSASPTAAGHAATVFWDTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1Q9</accession>
    <name>A0A3P9B1Q9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ADAMTS-like 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_014266683.2">
        <property type="nucleotide sequence ID" value="XM_014411197.3"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005003858"/>
    <dbReference type="Ensembl" id="ENSMZET00005004017.1">
        <property type="protein sequence ID" value="ENSMZEP00005003858.1"/>
        <property type="gene ID" value="ENSMZEG00005002988.1"/>
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    <dbReference type="KEGG" id="mze:101469981"/>
    <dbReference type="CTD" id="57188"/>
    <dbReference type="GeneTree" id="ENSGT00940000158143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000025">
        <property type="entry name" value="ADAMTS like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000009">
        <property type="entry name" value="ADAMTS-like protein 3 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF169">
        <property type="entry name" value="ADAMTS-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
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    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018030325" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="926"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1256"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1370"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="10">
        <location>
            <begin position="1718"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="890"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="99"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="8">
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            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000259" key="9">
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            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="PROSITE" id="PS50900"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1758" mass="193442" checksum="99E6705ED9704A05" modified="2019-02-13" version="1">MKMESFTFCRTVLIFFMFPCVQCSESQTAVFLPEFALSPQGSFMEDATEDHFLTYKYDDQASRMTRSDEDREIGWDAWSAWSDCSRTCGGGASYSLRRCLNGGSCEGKNIRYRTCSNTDCPAESGDFRAQQCSAHNDIKYQGVTYEWVPAPYDPTAPCTLRCQAKGRSLTVELAPKVLDGTRCRADAFDMCISGVCQEVGCDRQLASGAREDNCGVCGGDGSTCRLVRGQALPHLTPEQSLKTVLEVPMGSRFLRLNAKGPDMIVIEAVSLQGRKEETDLQSTGSYVIGNTSLDFQRGNDRQTLRTHGPLGADYIIKIKYGGSKDTVVQFLFYKPIRYQWRETDFFPCSVTCGGGYQLNSAECTDIRSNQTLPEHHCNSYPENTKPTPKLKECNMDPCPESDGFKAVMPHDRFQPLPRWEQGPWTQCSVSCGENGGWQDRSVLCVEEDAHGQFSQVDEWKCTHSPRPVARQICNTFACPQWVAMEWSQCTVTCGRGLRYRVVLCIDHRGQHVGGCSPSLKPHVKEDCLVPVACHKPRESLPVEAKLPWSKQAHELEEHYTATENPTFIPGPWSPCSTTCGPGRQTREVKCQVLLTFTKTEVDLPEEECGGDRPQLERPCNHGPCTRATAVRDHGAPLFQADDLHSWDFRGFTACSATCAAGKQTAVVRCVNRKQDEEVDDALCDPSSRPSVMIRICNPEPCPPRWEVTAWTGCSASCGVGIQTRSVFCMRLLSVDQQDIQTISEDACTDFRPAILQPCNQVDCPPAWETEAWQQCSQTCGDGVQVRKVYCKQLLSTGAYRWLGDDACQVTKPATNRGCGNMDCVPYTAGGEWGKCSVSCGLGIQRRELLCLQLTAAGRQVTVAREQCSGLPSPPLVRTCRMMACPKHKKQMRPKDSRKAAVKNQVKQPVRRPAKTRGYEEGIKQCPALISTHNIYIQTRKERRLHLTVGGHAYLLPNTSVVIKCPVRRFPKAYIRWLKDGSALPSSQRLGVTKSGSLKIQFLEPEDTGVYKCVAGPASDIFTLQLIGGDGSSAGRPPAPGPDWEEMLPSCYSHDSVLKTIRPGARVSLVPAGGQEASLQPRVEERLINVTLQADRGEIQQEQASELISSLLTHMSPAQLWTRTTRRGGQAKDRLPNWSEHSPLETVAKRPAIIRQQQSVPSTFQKNIDISIGHSALLTNATRSLTIRCPAEGSPPPKISWSKDGALLQHSDRVSWDRAGLHILQLRASDRGQYRCAAANALGSDSEASQLLLAEPPAIAVSWRNVSDHGGMLGHSLTATVGGQISIRPGANLTVDCPVSGVPRPTVLWHRKDGLLDAGAVSLPSGSLWIRNVSVHNQGTYSCAATNAIGKSTASTVLKVHDPAGGSRVLPASQELSRRRVLMASRRGTSVFIKPGDVLRIGCPVVSDHKPPVRWEYNNRTLKEVSAPAHSPDPGQGLQHRMLVGGRVLEVSTLQGKFAGRYRCQTFINSTRQILSAWIYVHSEEFGWRFGGWTTCSTSCGSRGTWLRRIRCVSLDGKDVHPDMCQRVPKPATSPVPCNRQACPPRWSVSEWSKCSASCGAGQKQRRVTCQQLDAGGAARTLPAAACEGTSRPADTEPCSANNCPVWVTSPWGKCSGRCLGPTTTLQKRSVVCQHANGSSYTDCDLRSRPVSVRNCSSDLCDVQWRPGAWRACTVVCGSGFQSRRVDCVHSKTGRTLADQHCAWLQRPSTWQHCNTATCGSECEDTTQYCSVVRRLRLCHVDTYKQRCCSSCLRGVDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B4Z3</accession>
    <name>A0A3P9B4Z3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Solute carrier family 25 member 17</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004558367.1">
        <property type="nucleotide sequence ID" value="XM_004558310.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B4Z3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004847"/>
    <dbReference type="Ensembl" id="ENSMZET00005005059.1">
        <property type="protein sequence ID" value="ENSMZEP00005004847.1"/>
        <property type="gene ID" value="ENSMZEG00005003737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485095"/>
    <dbReference type="KEGG" id="mze:101485095"/>
    <dbReference type="CTD" id="566378"/>
    <dbReference type="GeneTree" id="ENSGT00940000165478"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000047">
        <property type="entry name" value="peroxisomal membrane protein PMP34 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="107"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="208"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34431" checksum="93203039B9A77F94" modified="2019-02-13" version="1">MSDNGGSAVGLLSYETLVHAVAGAMGSVTAMTVFFPLDTAKSRLQVDEKRKSNSTPVILAEIAKEEGFLSLYRGWFPVISSLCCSNFVYFYTFNSLKKLMASGPGQSRPGKDLLIGIVSGVVNVILTTPMWVVNTRLKMQGVKFRNEDLHQTHYRGIFDAFSQIIANEGVGTLWNGTLPSLVLVLNPAVQFMIYEAMKRKAGRGGRKISSAKIFLIGAIAKAIATTATYPLQTVQAILRFGQYTSDAEGGGVMGSLSNILFLLMDRIKKHGALGLYKGLEAKLLQTVLTAALMFVVYEKIAAVTFRLMGMNKKLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B590</accession>
    <name>A0A3P9B590_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B590"/>
    <dbReference type="Ensembl" id="ENSMZET00005005293.1">
        <property type="protein sequence ID" value="ENSMZEP00005005069.1"/>
        <property type="gene ID" value="ENSMZEG00005003336.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153582"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001530">
        <property type="entry name" value="Zinc finger protein 268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000475">
        <property type="entry name" value="zinc finger protein 32 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000736">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="431" mass="49663" checksum="79F24012C1BD0BE2" modified="2019-02-13" version="1">VAFEPEAPQIKEEQEQLCSSQEGEQLVLKEENHTFMVTAAEKRDHSEPEPTRDQLNCKDSQSRRNKKKGHNNSLKCDVCGKAYKYNYEMERHYRIHTGEKPFSCKTCGKMFARSGSVVQHMRIHTGEKPYSCKVCGKSFRQTNGLTVHMITHTGEKRYHCEICGKMFARSNGLLRHKKVHTSEKPYYCKTCGKTFPLRNLFLIHTKRHTGEKPYHCKTCGKMFKRNSHLKEHIRIHTGEKPYHCKTCGNSFRYQDSPTSEGQCNTHIGKKSVTCNVCGKLFKNKYKIHEHHRIHTGEKPYLCETCGKSFTQGGSLLVHMRTHSGEKPYTCNTCGERFCYLLALKKHKAVHTGENPFFCTTCGKTFTQRGSLLVHMRIHSGEKPYSCKTCGKSFTKKCTLLVHVRIHTEDPENNKDIFHHHVSASLNLVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5E9</accession>
    <name>A0A3P9B5E9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004574268.1">
        <property type="nucleotide sequence ID" value="XM_004574211.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004574269.1">
        <property type="nucleotide sequence ID" value="XM_004574212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5E9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005129"/>
    <dbReference type="Ensembl" id="ENSMZET00005005353.1">
        <property type="protein sequence ID" value="ENSMZEP00005005129.1"/>
        <property type="gene ID" value="ENSMZEG00005003981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471760"/>
    <dbReference type="KEGG" id="mze:101471760"/>
    <dbReference type="CTD" id="369"/>
    <dbReference type="GeneTree" id="ENSGT00940000159633"/>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900108">
        <property type="term" value="P:negative regulation of nodal signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060392">
        <property type="term" value="P:negative regulation of SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20870">
        <property type="entry name" value="C1_A_C-Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17133">
        <property type="entry name" value="RBD_ARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000015">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000024">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000004">
        <property type="entry name" value="B-Raf proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000036">
        <property type="entry name" value="RAF proto-oncogene serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF55">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE A-RAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00455">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50898">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RBD" evidence="15">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="313"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="159"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="248"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="611" mass="68845" checksum="7DFDB07EEEEEE676" modified="2019-02-13" version="1">MSSTSSSYSSSGETSPEDPPRGGGTIRVYLPNKQRTVVNVRQGQTVHEILDKALKVRGLSQECCAVFRLLGGRKRLTDWDTDITPLVGEELLVEVLDDIPLTMHNFVRKTFFKLAYCDFCHKFLFNGFRCQTCGYKFHQHCSSKVPTVCVDMDTIRERSDPSPCPDGYPQIILPENSPTQSNPALTPEPSGMGHLSPSPSSTFHFPMSGGDGQSLQRHRSTSTPNVHMVSTLDPASAMIIEEALKFNNTIGPEPSPKPSTSPPSSFGSPGKKPPKSPSEPRERKPSSSDDKKKVHRGGNRDSSYYWEVHSREVNIQKRIGSGSFGTVFKGKWHGDVAIKILKVKEPTPEQLQAFKNEMQVLRKTRHVNILLFMGFMTKPNFAIITQWCEGSSLYRHLHVLESKFDTVRRIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGWTVKIGDFGLATVKARWTGSQQVEQPSGSILWMAPEVIRMQDTNPYTFQSDVYGYGVVLFELMSGTLPYSNINNRDQIIFMVGRGYLSPDLSKLYSTSPKAMKRLIVDCLKFKRDERPLFPQILVSIEQVQDLLPKIERSRSEPSLHRAVHAEDLNPLLFHTTRLMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5Y0</accession>
    <name>A0A3P9B5Y0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5Y0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005304"/>
    <dbReference type="Ensembl" id="ENSMZET00005005532.1">
        <property type="protein sequence ID" value="ENSMZEP00005005304.1"/>
        <property type="gene ID" value="ENSMZEG00005004119.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234535"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF50">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE 8F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="109"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="324" mass="37141" checksum="EE43AD6251C88501" modified="2019-02-13" version="1">HSLEFHRPLPQRSASKPSELCKGCKEAIDKVKKLYNQTWKKQEENYHRFRLQLNINCNGSNNGIITQENTPVGSKIVCDKDRTVIPVTPVLFKAFIKENPFSKKRWDTCSVVGSGGILTNSGCGKIIDSADFVFRCNLPPLENEFKNDVGIKTNLVTANPTIFINKYGSLTGRRRQFADSLHQYGNSLLLFPCFSFGFSRGVCQRAVYAIEDMKIPIQPIFLNPLYLERLVKFWKSQGLKEYRPSTGLYITSLALELCETVHLYGFWPFSNHPDRLFPLTNHYYDNVPYNARVHSMPNEFYHWVQLHNKGVLKLHLGDCKSGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B788</accession>
    <name>A0A3P9B788_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B788"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005677"/>
    <dbReference type="Ensembl" id="ENSMZET00005005927.1">
        <property type="protein sequence ID" value="ENSMZEP00005005677.1"/>
        <property type="gene ID" value="ENSMZEG00005004397.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044904"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="3">
        <location>
            <begin position="47"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="290" mass="32757" checksum="37B478DB6D88067F" modified="2019-02-13" version="1">ILFGETSNQQSESARPPPVYQLNPKKKMFGTLTKMTVGEKNQKKTNKTILLVGETGAGKSTLINALVNYTMGVKWEDEVWFQIIEEEEESQSESQTSDVIVYEIFGFEDETLPYSLTIIDTPGYGDTRGTEDDVIVSKRLLDLFRSDDGVHEVHAVGLVMKASENRLSDRLRYVFDSVISLFGKNLEKNIVALITHSDGVTPENALEALEAAKIKCARIEDEPVCFLFNNQQEKERKKKDKVGLHNAWRVSEGGMSEFSEFLENIEPQKLMTTVEVLNERIRLTACIQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B7W8</accession>
    <name>A0A3P9B7W8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Paired box 3b</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B7W8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005998"/>
    <dbReference type="Ensembl" id="ENSMZET00005006259.1">
        <property type="protein sequence ID" value="ENSMZEP00005005998.1"/>
        <property type="gene ID" value="ENSMZEG00005004628.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156504"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014707">
        <property type="term" value="P:branchiomeric skeletal muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002834">
        <property type="term" value="P:regulation of response to tumor cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000080">
        <property type="entry name" value="paired box protein Pax-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000035">
        <property type="entry name" value="paired box protein Pax-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000031">
        <property type="entry name" value="Paired box protein Pax-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022106">
        <property type="entry name" value="Pax7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF17">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12360">
        <property type="entry name" value="Pax7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="15">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="220"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="162"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="302"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="522" mass="57350" checksum="4363B171D7C018D5" modified="2019-02-13" version="1">MTALAGSIPRMMRPSLTQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQGTSPDVERRIEEYKRENPGMFSWEIRDKLLKDGICDRNNVPSVSAISRIMRSKFGGKGDEEEDEDEIEKKELEDNERRAKHSIEGILGDRSSHSDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPSAMSSIQPYQLSDSSYPPSSIAQVVSEPPSTVHRPQPLPPSSGHQASGGQGEGGSAYCLASGRHSFSGYSDSFVSPGAPTNPMNASIGNGLSPQVMGLLNPGGVPHQPQSDYAISPLTGGLETPAGMAASCSQRMDHIKGLEGLTSVPSMSALPSLPSSQSYCPPSYSSPGYTVDHVASYQYSQYGQSKVNKLHLFYSYLLVNNALKCHYLDMVPVFAVFFNAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8F0</accession>
    <name>A0A3P9B8F0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase Midline-1</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING finger protein Midline-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">RING-type E3 ubiquitin transferase Midline-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Tripartite motif-containing protein 18</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004552662.1">
        <property type="nucleotide sequence ID" value="XM_004552605.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004552663.1">
        <property type="nucleotide sequence ID" value="XM_004552606.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8F0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006155"/>
    <dbReference type="Ensembl" id="ENSMZET00005006434.1">
        <property type="protein sequence ID" value="ENSMZEP00005006145.1"/>
        <property type="gene ID" value="ENSMZEG00005004790.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005006444.1">
        <property type="protein sequence ID" value="ENSMZEP00005006155.1"/>
        <property type="gene ID" value="ENSMZEG00005004790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466449"/>
    <dbReference type="KEGG" id="mze:101466449"/>
    <dbReference type="GeneTree" id="ENSGT00940000155821"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19836">
        <property type="entry name" value="Bbox1_MID1_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19822">
        <property type="entry name" value="Bbox2_MID1_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047095">
        <property type="entry name" value="MID1_Bbox1_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027727">
        <property type="entry name" value="MID1_Bbox2_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040859">
        <property type="entry name" value="Midline-1_COS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF23">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIDLINE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18568">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="23">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="26">
        <location>
            <begin position="342"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="403"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="24">
        <location>
            <begin position="488"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="689" mass="77012" checksum="E1FDCBC8734A295E" modified="2019-02-13" version="1">MDTLESELTCPICLELFEDPLLLPCAHSLCFGCAHRILVSHCTTNESVQSIGAFQCPTCRYVISLSPERGLEGLKRNVTLQNIIDRVQRASSSAGLPLPLLLPAPHSGPSSPGEEGSNRLALVPLSAAMSSPSTPPEPVQCQFCEQDPPQDAVKTCVTCEVSYCDECLRATHPNKKPFTGHRLIEPMPDCHLRGLQCLEHEEEKVNMYCVTDDQLICSLCKLVGRHRDHQVAALSDRYEKLRQALDSNLSNLIKRNNELESLMGKLIQTCQHVEVNASRQEGKLLEECDVLIDIIQQRRQIIGNKIKEGKAQRLRKLAQQISNCKQCIERSTALITQADQTLKETDHARFLQTAKSINERVSMATASTQVLIPEIHLTDTFDTFALDFTREKKLLENLDYLTAPSAPCIREELCTASYDTITAHWTSDDEFTVTSYELQYAIFTGQSNIASLCNSLESWMIVPNIKQNHYTVHGLQSGTKYIFVVKAINQAGSRSSEPGTLKTNSQPFKLDPKSAHKKLKVSHDNLTVERDETTSKKGHSQERFASQSSYGVVGNVYIDSGRHYWEALIGGSTWYAVGIAYKSAPKHEWIGKNSASWVLCRCNNSWVVRHNSKELAIEPSPHLRRVGVLLDYDSGYLSFYDAVGSQHLHTFHVSFIQPVCPVFNVWNKCLTILTGLPIPDHLEGLEPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8M7</accession>
    <name>A0A3P9B8M7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ADAM metallopeptidase domain 28</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8M7"/>
    <dbReference type="Ensembl" id="ENSMZET00005006557.1">
        <property type="protein sequence ID" value="ENSMZEP00005006268.1"/>
        <property type="gene ID" value="ENSMZEG00005004829.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156716"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF32">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="192"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="389"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="344"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="622" mass="68773" checksum="492A405AC496D994" modified="2019-02-13" version="1">MRWFDRSDFTQSEKDTQRFLFFSILNPVMTIKFLLIMENEKIKMNDSKQNFLFFCPQYHRPDTLTYAMTVVFTSLNLYEKKVTCCHLITQSPFSCPCQDHCFYHGRIVNDSESSVSISTCDGLRGYFRTSAQRYLIEPLSSDDEGDHAVTTFNEKNFTPAVCGVTNTSWSDDYEPPTSRSRSRSGVTQLQQKYVELVLVADNRYVKMNRDQKKMRQRIFEIVNFVNMVYKPLRTFIALVGLEIWTNGDLISVTPPAGANLDAFMKWRNSELVTRIKHDNAHLISGIDFEGPTVGLAFIGTLCSGHSVGVVQDHSDAAIAVGATLSHEMGHNLGMDHDDSSGCLCSDDSCIMAAALSFSSCSSSNYEKYLTSCSPSCLLDKPDYKSVVAPAVCGNGFREEGEQCDCGSVQECTNPCCNATTCTLKEGSQCAEGECCENCKILPTSRQCRSKQDDCDLAEYCDGKSTTCPEDVFAVNGLPCDGGQGYCYNGQCPQRPKQCVKMYGSGAKEAKQGCYNYNTRGVYYGFCKRPSNNQFIPCQQEDVLCGKLFCEGGNDNPNYGRMVAIGTCKAAFFSDNTGDQGLVETGTKCGDGKVCSQNQCVDLQTAYRNTNCSAKCPGHAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8Q5</accession>
    <name>A0A3P9B8Q5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
            <ecNumber evidence="4">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cell division protein kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">p34 protein kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Forms a stable but non-covalent complex with cyclin B in mature oocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EC" id="2.7.11.23" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004573867.1">
        <property type="nucleotide sequence ID" value="XM_004573810.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8Q5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006265"/>
    <dbReference type="Ensembl" id="ENSMZET00005006554.1">
        <property type="protein sequence ID" value="ENSMZEP00005006265.1"/>
        <property type="gene ID" value="ENSMZEG00005004857.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478485"/>
    <dbReference type="KEGG" id="mze:101478485"/>
    <dbReference type="CTD" id="983"/>
    <dbReference type="GeneTree" id="ENSGT00940000153335"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035881">
        <property type="term" value="P:amacrine cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009794">
        <property type="term" value="P:regulation of mitotic cell cycle, embryonic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042670">
        <property type="term" value="P:retinal cone cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060221">
        <property type="term" value="P:retinal rod cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07861">
        <property type="entry name" value="STKc_CDK1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000231">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF334">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 27 28" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11 27 28" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 28" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="27">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00046122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="303" mass="34678" checksum="AE5A708F907C7C00" modified="2019-02-13" version="1">MEDYLKIEKIGEGTYGVVYKGKHKATGQIVAMKKIRLESEEEGVPSTAVREVSLLQELKHPNVVRLLDVLMQESRLYLIFEFLSMDLKKYLDSIPSGQYMDSMLVKSYLYQILEGIYFCHCRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPRYSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVWPDVESLPDYKNTFPKWKSGNLSSMVKNLDKNGLDLLAKMLTYNPPKRLSAREAMTHPYFDDLDKSTLPAANINKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8X1</accession>
    <name>A0A3P9B8X1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8X1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006349"/>
    <dbReference type="Ensembl" id="ENSMZET00005006639.1">
        <property type="protein sequence ID" value="ENSMZEP00005006349.1"/>
        <property type="gene ID" value="ENSMZEG00005004902.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155774"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000681">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="68"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="456" mass="50376" checksum="AC32D343BFB4F3EE" modified="2019-02-13" version="1">MADEESVKPKTYETLEISSSDEGSDHGDGGENDETVKSFKDLGVTDVLCEACDQLGWKSPTKIQIEAIPVALQGKDVIGLAETGSGKTGAFALPILQSLLASPQRLHTLVLTPTRELAFQISEQFEALGSSIGVKSVIVGGIDMMSQSLVLAKKPHIVIATPGRLIDHLENTKGFSLRALKFLVMDEADRILNMDFETEVDKILKVIPRERRTFLFSATMTKKVQKLERAALKDPVKCAVSTKYSTVDKLQQYYIFIPSKYKDCYLVSILNELAGNSFIIFCSTCNTAQRVALLLRNLGITAIPLHGQMSQSRTIWKIHHFRHSVRRAFLLSPVIPYTITSLKVTAASKCVWCPYNHRYDVELFQRIESLIGKKLPAFPTQEEEVMMLVERVSEAQRFAKIEMKEQGDKRKRPKRGDGDDDDTEQATGVRKKVKGGGGGGGGGGKKRGGGAWRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9I5</accession>
    <name>A0A3P9B9I5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 593</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome. Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with pre-60S ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004540521.1">
        <property type="nucleotide sequence ID" value="XM_004540464.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004540522.1">
        <property type="nucleotide sequence ID" value="XM_004540465.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004540523.1">
        <property type="nucleotide sequence ID" value="XM_004540466.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9I5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006540"/>
    <dbReference type="Ensembl" id="ENSMZET00005006838.1">
        <property type="protein sequence ID" value="ENSMZEP00005006540.1"/>
        <property type="gene ID" value="ENSMZEG00005005052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484729"/>
    <dbReference type="KEGG" id="mze:101484729"/>
    <dbReference type="CTD" id="51042"/>
    <dbReference type="GeneTree" id="ENSGT00390000004173"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="129" mass="15155" checksum="ECFCB49D16516857" modified="2019-02-13" version="1">MGKSKQTRNHNNGKKKNIAKTWKTKRRTKDLDQIHSDMKPDTAAKLLHQEVDYDVTGCAQHYCLHCARYFVDMRSLKEHFKTKVHKKRLKQLREEPYTQEEAERAAGMGSYIPPKVVEVKTQPLEEDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9M1</accession>
    <name>A0A3P9B9M1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">CBY1 interacting BAR domain containing 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the CIBAR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9M1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006613"/>
    <dbReference type="Ensembl" id="ENSMZET00005006911.1">
        <property type="protein sequence ID" value="ENSMZEP00005006613.1"/>
        <property type="gene ID" value="ENSMZEG00005005095.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010285"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07598">
        <property type="entry name" value="BAR_FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035590">
        <property type="entry name" value="BAR_CBAR1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009602">
        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223:SF4">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06730">
        <property type="entry name" value="FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="282" mass="32961" checksum="0022656DCC6969E7" modified="2025-10-08" version="2">MMFSFILSRDNQTRRIQENITNVEKHFGQMCQLFAAYVSKTAKVRDKADLLVREISLYADTETPSLKRGMKQYADHLAKIQDYRQAQVERLESKIIEPLKSYGAVVKRKREDLKTTQSARDREAKQMAQLERTRQRNPSDRQIIAESELQRATMDATRTTKQLEETIDEFERQKIQDIKKIFCEFVTVEMSFHAKALEVYTLAYQSIQSVDEEEDLEVFRSSLHPPDYQSRLDIVRANSKTSLDRTGSFLNSTGTLQVRYKEDEDESEEDVDEDEDDTDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAJ8</accession>
    <name>A0A3P9BAJ8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myotilin</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the myotilin/palladin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAJ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006924"/>
    <dbReference type="Ensembl" id="ENSMZET00005007227.1">
        <property type="protein sequence ID" value="ENSMZEP00005006924.1"/>
        <property type="gene ID" value="ENSMZEG00005005325.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159795"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000702">
        <property type="entry name" value="Myotilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001108">
        <property type="entry name" value="palladin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF23">
        <property type="entry name" value="MYOTILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="589"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="688"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061540"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="827" mass="89661" checksum="F96E033FDBC13A9F" modified="2019-02-13" version="1">MLEVYDDLDEQLEAEAIHQEAVSIRQDKEAMSQQETLSCRASSRDFPPGLSDSINLPPPEWPDSAVEDDIPVADFPEPQLANQYSDEIFGRSEDEIALSSEGQRSPEVTAQTCTSSPTPPPSPSPPPEVKEKAQAPKLFTPSKLSFTSSQSGGNNMNLSDLPTFTPSTFPPSAFNYERPRHFIQSQPAFQAPSYDSVLKEAQENQNNSQQNLNSAQKSPNVLETQIQTKAMSTQSQSFSQSASKSLSETQSQLQSLSLSHNQYQSAAPPQIHIQANGTAKSSPSSSSLSSPVSTPASSAVPALSSAGPILSHSPTSFSSLPSSSLPRTTMRSTITLTPSVPSATGLGSATLPANQDSMSASAAYLCSVLPSQSSSKLSPNTNRPLSSTSPSRSPLAPSSPLLPLRTSFSSSALPQQPPPVSPSLPCSPLSSSSSPSCVPQQPFTPSTQNSVQPAVVSLPASYKGTPSTLPKPILKKAIAPRPSSARSTDEDIQGSKDALIQDLEKKLRSKEARRRNSQKLSYEERMARRLLGPDNTTYMFDQDNLSDSQLDQPDSPEGRHTGGLWGRHHSRTDERGNEGLAIQEKCYAPRFLQVPPDLTVEEGRFCRLDFKVGGLPTPDVSWYLDGKAIRPDDYHKMLVCEKGMHSFIIEIVTVHHAGVYECVARNRAGESRFTMRLNVIAQEALRPPTFVQKMVNSRALEGDTIRLECKVDASPPPQLFWKKDKDMLRIDPNRMSLYQDGSGRQCLLIERVMKSDAGWYTLSAINEAGMSTCNARLDVGTRTTPAMKTAPAGSKTLKLLSSLSHVPALTVESPAQHTAPLYESEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD93</accession>
    <name>A0A3P9BD93_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 19 member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD93"/>
    <dbReference type="Ensembl" id="ENSMZET00005008054.1">
        <property type="protein sequence ID" value="ENSMZEP00005007736.1"/>
        <property type="gene ID" value="ENSMZEG00005005398.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183022"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Solute carrier family 19 member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF37">
        <property type="entry name" value="THIAMINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028739">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="497" mass="56135" checksum="CFD89018D3157767" modified="2019-02-13" version="1">MKWHLSGCSFRPAAATLSNTCLRAVKKWRSDWKYPTILLCIYGFFSTVKPLEPFLIPFLTGPDKNLTTEQVNNQIFPVWTYSYLSVLVPVFLLTDWLRYMPVVVFQCVMLFITTALLLWTASVPAMQATQFFYGVVTASDIAYFSYIYSVIDLKRYRKATSYSRSVQLLGYTVGSVLGQLLVSFDLMSYNNILVFTLVLTAIALLTSFFLPVPQKSMFFHQRRGRQTAAEQSNTINASLENGGGEMVESGEGEPDAEKLEESIVTQSCGQVLLQLWRDFRHCYSSRQLLYWSVWWAMATCGYNQTVNYVQVLWEHVQPSQNFSIYNGGVEAVSNLLSAATAYGIGFTEVRWEQWGELALGGFSGLSAASLFLMTFTGNIWVCYSGYVVFKSLYMMLITIAMYQIAADLSMERYALVFGANTFGALALQTIITSVVVDSRGLGLAIIPQFTVYSSYFLVISVVFLLRGLFSIWRAQRSRKETIPPDKDETPGSEEHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDL6</accession>
    <name>A0A3P9BDL6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Low-density lipoprotein receptor-related protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Glycoprotein 330</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Megalin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="37 38">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Endosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Membrane</location>
            <location evidence="26">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005008014"/>
    <dbReference type="Ensembl" id="ENSMZET00005008336.1">
        <property type="protein sequence ID" value="ENSMZEP00005008014.1"/>
        <property type="gene ID" value="ENSMZEG00005006004.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157232"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031904">
        <property type="term" value="C:endosome lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000049">
        <property type="entry name" value="LDL receptor related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000198">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000001">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000004">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000011">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000072">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000805">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000035">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000040">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000057">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000108">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000147">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000159">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000008">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF11">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24468">
        <property type="entry name" value="EGF_LRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="25" id="KW-0966">Cell projection</keyword>
    <keyword evidence="23" id="KW-0168">Coated pit</keyword>
    <keyword evidence="21 31" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 31" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0967">Endosome</keyword>
    <keyword evidence="24" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1009">Hearing</keyword>
    <keyword evidence="20 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
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            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004539760.1">
        <property type="nucleotide sequence ID" value="XM_004539703.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004539761.1">
        <property type="nucleotide sequence ID" value="XM_004539704.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012775174.1">
        <property type="nucleotide sequence ID" value="XM_012919720.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012775175.1">
        <property type="nucleotide sequence ID" value="XM_012919721.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDU0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008052"/>
    <dbReference type="Ensembl" id="ENSMZET00005008374.1">
        <property type="protein sequence ID" value="ENSMZEP00005008052.1"/>
        <property type="gene ID" value="ENSMZEG00005006123.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482061"/>
    <dbReference type="KEGG" id="mze:101482061"/>
    <dbReference type="GeneTree" id="ENSGT00390000012054"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004060">
        <property type="term" value="F:arylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2140.20:FF:000001">
        <property type="entry name" value="Arylamine N-acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF8">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="290" mass="33203" checksum="C1E1ACCDCAD6CD59" modified="2019-02-13" version="1">MNLDEYFKRIGFHGSYDKLDLATLKLIHRQHVMSIPFENLSIHCGEKITMDLEVIFNKMVRSSRGGWCLENNSLFGWVLRQMGYDTTTLGSRVFSPTGGEYHSEETHLINKVIIDGKAYIADVSFGVSLQLWEPLELISGKEQSQAAGVFRLIDKGDMWMLEKTGRKPEVPNPEFAKSSLLDKKQTQVIYSFTLEPREPYHFSQVNHDLQSDPTSLFINKSICSLQTPTGFRALVGWTYSEVTFKPEEGVDVYDMRNVTDDALEEILREKFNVKLQNKLKAVNKKACYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDU7</accession>
    <name>A0A3P9BDU7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDU7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008100"/>
    <dbReference type="Ensembl" id="ENSMZET00005008422.1">
        <property type="protein sequence ID" value="ENSMZEP00005008100.1"/>
        <property type="gene ID" value="ENSMZEG00005006163.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164988"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071875">
        <property type="term" value="P:adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="42"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="451" mass="50188" checksum="AF98399D0B390D54" modified="2019-02-13" version="1">LRNKVFLIFYLVVITLEEYVEIAFVLANSFILSSTSVVGAAANVFVILAVYRQKSLQTSNNALVVSLAVIDFLRCVIDCPVLLTIVVSVYRNRKVDSFICDVQMASFSFSCCIQLLTLACISAERYQAIAQPFKANQRKRRIKALIPLTWTFAILVSAFCVIFLRDSPLHMKCQRQQRETLFSFDKFGLYMLFPLWAACFGVIIGFYARIFALVRSHSRKIFDKGTFTLATKDKNEEKPETEKAAVVENECGRFEQNPTLSLGNAQTQAESNSPKEKSVQSVSINSEDKKEFKDTVKMSNAETKQARPLPVQATVLTEKKPLKTEQSNPHVMKVEVNLSNGDADSNVKSLTTKRASVSFNTQEQSKDRLKSEEESKENSLLQPPSLPAPNVNSQSTTILLTEPDQALNNNEGETLTVASQAQVTASPPVSSNVPETEAICTVDLFFLSLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEF0</accession>
    <name>A0A3P9BEF0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="5 17">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
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    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="12 17" id="KW-0442">Lipid degradation</keyword>
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    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="19">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
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            <begin position="199"/>
            <end position="234"/>
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            <begin position="468"/>
            <end position="500"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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            <begin position="482"/>
            <end position="498"/>
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    </evidence>
    <sequence length="789" mass="89501" checksum="97F94E2C05F38084" modified="2019-02-13" version="1">MLGNRKKAIPQVKNGAGTSELKAIDPLRNLGVQNDEDVRQMLQGSSMVKVRSPRWQKRRILKLLEDGVTVWCQSYKTSSRAKEQQSFSIMEVECVHEGCQSETLQQMVGSVPENQCLTVVFKGSRKSLDLLCQSQEEAQCWARGIRTLLHVKIHHMAHQCFLDSVTWIHAYMSRADRNRDDKMSYDEVQILLQMINIDLNDQYSRSLFQKCDQSGDGRLDHGEIEVFCRELLRRPELDIIFIRYSANGCVLSAVDLRDFLKDQGEDASLVHAQSLILTYELNEWAQKNSFMTPNGFTMYMLSKENCVFNPEHARVYQDMAHPLSHYFISSSHNTYLTKDQLTGNSSTEPYIRALKHGCRCVELDCWDGDKGEPVIYHGHTLTSKVPFVEVIETINEYAFKSSPYPLILSLENHCSLEQQKVMARHLHSILGDKFLTKPLEGLDSHNLPSPEALKGKVLVKGKKERLEECSSSSSDLSSSDEETSRIEGKPRRKEDKKAGVSKITPELSDLVVYTCSVPFKSFEQAAKSPATNMSSFSESDALRHIKDSGVYFVRHNSHHLSRIYPSGQRLHSSNYNPQEMWNAGCQIVALNFQTPGEQMDLNQGRFLQNGECGYILKPAFLCQPDSTFNPENVGGGPGHRPVMLTVRVISAQQLPKPEWDKPSSIVDPQVWVEIHGAPIDNNKKKTHYVENNGFNPRWDCTFNFTVHVPDLALVRFLVEDHDYTSRNDFLGQFTLPFPSVRTGYRHVRLLKMDGSSLSPASLFIHIKVTPCQNSKSSAKSPTHFPTKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFD2</accession>
    <name>A0A3P9BFD2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Somatostatin receptor 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BFD2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008624"/>
    <dbReference type="Ensembl" id="ENSMZET00005008964.1">
        <property type="protein sequence ID" value="ENSMZEP00005008624.1"/>
        <property type="gene ID" value="ENSMZEG00005006519.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156544"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
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        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004994">
        <property type="term" value="F:somatostatin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071392">
        <property type="term" value="P:cellular response to estradiol stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071385">
        <property type="term" value="P:cellular response to glucocorticoid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000060">
        <property type="entry name" value="Somatostatin receptor type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000586">
        <property type="entry name" value="Somatstn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF6">
        <property type="entry name" value="SOMATOSTATIN RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00246">
        <property type="entry name" value="SOMATOSTATNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="64"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="357" mass="39869" checksum="34E7CE1EFD094591" modified="2019-02-13" version="1">LGSVALPPTSPNNSIPEPFWYDIQGNDSDLGFNISQDKEHHQDKTSSVVITFIYFMVCAVGLCGNTLVIYVILRYAKMKTVTNIYILNLAVADVLCMMSLPFIALQLALVHWPFGEALCRMILNSLNQFTSIFCLMVMSIDRYLAVVHPIKSTNVWGVSLLVILPTLIFSGLNKVPVCGIVWPEPQDVYYTAFIFYTFFIGFFLPLAVICMCYLLIIVKVKSSGLRVGSTKRKRSERKVTRMVSIVVAVFVLCWLPFYIFNVTSVTGSIKPTSAVKSTFDFVVVLGYANSCANPILYAFLSDNFKKSFQNVLCLKSRADRSKMINEASIINANLYTHILPCSMANCRPAFKGVPVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHF3</accession>
    <name>A0A3P9BHF3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High mobility group 20B</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004552820.1">
        <property type="nucleotide sequence ID" value="XM_004552763.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004552821.1">
        <property type="nucleotide sequence ID" value="XM_004552764.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BHF3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009339"/>
    <dbReference type="Ensembl" id="ENSMZET00005009689.1">
        <property type="protein sequence ID" value="ENSMZEP00005009339.1"/>
        <property type="gene ID" value="ENSMZEG00005007077.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482719"/>
    <dbReference type="KEGG" id="mze:101482719"/>
    <dbReference type="CTD" id="10362"/>
    <dbReference type="GeneTree" id="ENSGT00940000161213"/>
    <dbReference type="OrthoDB" id="3213154at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF2">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="294" mass="33567" checksum="4D1592A474980E23" modified="2019-02-13" version="1">MGGIKQEQSDASHQPKASQTADQPPEEPKKRGWPKGKKRKKVLPNGPKAPVTGYVRFLNERREHMRARYPDLPFPEITKRLGAEWTRLAPMDKQRYLDEAEREKMQYAQELKEYQQTEAYQITSAKIQDKRIKKEDTPSAVIGTSSGSSLTKASDLSNRFDIPIFTEEFLDQNKAREAELRRLRKANIEFEEQNAVLQRHIKDMYNAKERLEAELGQDEKRTQALQQHLMAIKHTLVNSLSSVPLPGTGETASLGNLDSYLSRLSGVLEGNPHKHRALLTQLCEVLSHLDSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHT1</accession>
    <name>A0A3P9BHT1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Si:ch211-129c21.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BHT1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009465"/>
    <dbReference type="Ensembl" id="ENSMZET00005009823.1">
        <property type="protein sequence ID" value="ENSMZEP00005009465.1"/>
        <property type="gene ID" value="ENSMZEG00005007139.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ossification involved in bone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cell migration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF135">
        <property type="entry name" value="SEMAPHORIN 4D ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="7">
        <location>
            <begin position="8"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="672" mass="74721" checksum="DF291882C6D0214B" modified="2019-02-13" version="1">MGLNDNLKLLVHLSALDINLKQFKESGFDSLSSLMVREDIGQLVLGARGKVLTLSLDDITKQTSENKWAVSSADKDLCQMKGKSAEECDNFIRTLHTMGDSKMLVCGTNAFNPVCDYMTLTNGTLSLERKTQTGRGKIPFDPYQRFATFMDGDTLYSAASTNFLGTESVFQRFGLNPVKTELKRSWLNGNFIFLDIKNSSKGEDGNVFLFFYENAVEELHGSIPVSRIARVCKSDLGGKRTLQQKWTSFLKARLNCPFGDVGSPSLVQDVFLLSDENDWRNSVFYATFISNSHSAVCAYKLSDISQVFSGRFLTELDTGNWDIYTGEEPSPYPGSCIDDEMRASGLTSSLNLSDTTLLFVKNHPLMEGVVSPMTGKPLLFKPMTHFSNIVVDQVTSLDGQQHLIMFVGTDTGWLQKAVKFEGEDGRIIEELQLFKEPQPVDFLQLSSKTGHLYSGTSNAVVQINLRDCSRYTSCDDCLLARDPYCGWDQIRSQCASVFGASNSSMIQSLSNGDITMCPPSESKKKPVTVYFNVNISQLLPCSPDTNLPIIWYFSHNVLHFGPQFTVLSLGLIIRPSYSDAGLYRCETVEAVKGRVHRKTIAQYLVKVHDTDAIMTNLRAAVCIMAAVVSLVSFSKAVFMVIGYLKSKKGNIRRGNKNCNNHQMRPASKWEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BL24</accession>
    <name>A0A3P9BL24_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Voltage-dependent calcium channel gamma-3 subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Neuronal voltage-gated calcium channel gamma-3 subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Transmembrane AMPAR regulatory protein gamma-3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="17">The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with AP4M1 and GRIA1; associates GRIA1 with the adaptor protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BL24"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010356"/>
    <dbReference type="Ensembl" id="ENSMZET00005010727.1">
        <property type="protein sequence ID" value="ENSMZEP00005010356.1"/>
        <property type="gene ID" value="ENSMZEG00005007804.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244893"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000002">
        <property type="entry name" value="Voltage-dependent calcium channel gamma-2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008368">
        <property type="entry name" value="VDCC_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF5">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01792">
        <property type="entry name" value="VDCCGAMMA"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <keyword evidence="9 18" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="238"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="315" mass="34624" checksum="9C0035CF6EDFA09E" modified="2019-02-13" version="1">MLMCDRGVQMLVTTVGAFAAFSLMTIAVGTDYWLYSRGVCRVKSSGDNDTSRKNEEVMTHSGLWRTCCLEGTFRGVCKKIDHFPEDADYEADAAEYLLRAVRASSLFPIMSVGLLFLGGLCVAASEFYRSRHNVILSAGIFFVSAGLSNIIGIIVYISANSGDPGQSDSKKSYSYGWSFYFGALSFIMAEMVGVLAVHMFIEKHRKLRAKSRTELIKKSAFSRIPSYRYRFRRRSSVRSSEAPSRDASPLGKGGYTGPAASEMPMYTLNPREAGNAGSKPVGGLGGLLNSERDFLQSSTLTKDYSKDPNRRTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQF8</accession>
    <name>A0A3P9BQF8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein SSUH2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004559053.1">
        <property type="nucleotide sequence ID" value="XM_004558996.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQF8"/>
    <dbReference type="Ensembl" id="ENSMZET00005012613.1">
        <property type="protein sequence ID" value="ENSMZEP00005012185.1"/>
        <property type="gene ID" value="ENSMZEG00005009154.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474146"/>
    <dbReference type="KEGG" id="mze:101474146"/>
    <dbReference type="CTD" id="101882914"/>
    <dbReference type="GeneTree" id="ENSGT00440000038003"/>
    <dbReference type="OrthoDB" id="3355217at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="368" mass="41946" checksum="6A52837F1C70458D" modified="2019-02-13" version="1">MDEKEEDVGTFDPNIPEEGPSAPPPGWLDDIHGYQGLKGGDDDNPLYPPPPAYNPQPEQNRSTSVPDVRVPSVSEDVARDALLKFVESKWNYSSKPARNLTFKDLQPITVYRYRLETYTETRASAWQFEPYNGQTVDGPQYGMSPAPWDIPVSLPQRYTDKVEKIRVPHSSFVKVCHKCKGCGRTRCTACFGRGQKRCTFCHGRGRIRNKHCTSCHGRGRKRCLSCHSHGYKTCSVCLGSQNLLHFIQLTVTWKNNVSEFIPDRQPDFPDRKFEKVSGDAFFVDESLLVYPIQGFPDQEICEVSTKLINEHLERFTATSRILQQRQSIELVPLTHAYYTYSGKDYSFFVYGLENKVFTSKYPSACSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQT9</accession>
    <name>A0A3P9BQT9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fumarate hydratase, mitochondrial</fullName>
            <ecNumber evidence="4">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FH</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:12462"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQT9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011981"/>
    <dbReference type="Ensembl" id="ENSMZET00005012394.1">
        <property type="protein sequence ID" value="ENSMZEP00005011981.1"/>
        <property type="gene ID" value="ENSMZEG00005008986.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183122"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="9">
        <location>
            <begin position="47"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="496" mass="53410" checksum="DF056E188625397B" modified="2019-02-13" version="1">MFRSLGRVQQFNCNFLTLQRLSATSKLHICTSRMASSDYRIERDTFGELKVPADKYYGAQTVRSTMNFKIGGPSERMPIQVIKAFGVLKKAAAQVNKEYGLDPKIAEAIVQAADEVSAGKLDDHFPLVVWQTGSGTQTNMNVNEVISNRAIEILGGKLGSKDPVHPNDHVNKSQSSNDTFPTAMHIAVATEVHQVLLPGLQTLHDALASKAEEFKDIIKIGRTHTQDAVPLSLGQEFSGYVQQVKYSIERVKAAMPRVYELAAGGTAVGTGLNTRIGFAEKVASTVASLTGLPFVTAPNKFEALAAHDALVELSGALNTVAVSMMKIANDVRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMVKNVLNSAQLLGDASVSFTNNCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAATIKKNSPVSLASCQKQSVPVSFCQDILSWFSPPHRFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSL3</accession>
    <name>A0A3P9BSL3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kynurenine--oxoglutarate transaminase 3</fullName>
            <ecNumber evidence="6">2.6.1.63</ecNumber>
            <ecNumber evidence="5">2.6.1.7</ecNumber>
            <ecNumber evidence="4">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cysteine-S-conjugate beta-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Kynurenine aminotransferase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Kynurenine aminotransferase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Kynurenine--glyoxylate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Kynurenine--oxoglutarate transaminase III</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O</text>
            <dbReference type="Rhea" id="RHEA:65900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:71201"/>
            <dbReference type="EC" id="2.6.1.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:65901"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O</text>
            <dbReference type="Rhea" id="RHEA:65560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
            <dbReference type="EC" id="2.6.1.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:65561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-kynurenine + glyoxylate = kynurenate + glycine + H2O</text>
            <dbReference type="Rhea" id="RHEA:65896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
            <dbReference type="EC" id="2.6.1.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:65897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:18122"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.63" evidence="6"/>
    <dbReference type="EC" id="2.6.1.7" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004552936.1">
        <property type="nucleotide sequence ID" value="XM_004552879.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774961.1">
        <property type="nucleotide sequence ID" value="XM_012919507.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774962.1">
        <property type="nucleotide sequence ID" value="XM_012919508.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774963.1">
        <property type="nucleotide sequence ID" value="XM_012919509.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSL3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012912"/>
    <dbReference type="Ensembl" id="ENSMZET00005013358.1">
        <property type="protein sequence ID" value="ENSMZEP00005012912.1"/>
        <property type="gene ID" value="ENSMZEG00005009689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486988"/>
    <dbReference type="KEGG" id="mze:101486988"/>
    <dbReference type="GeneTree" id="ENSGT00940000155827"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047315">
        <property type="term" value="F:kynurenine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000262">
        <property type="entry name" value="Kynurenine aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF6">
        <property type="entry name" value="KYNURENINE--OXOGLUTARATE TRANSAMINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="22">
        <location>
            <begin position="62"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="449" mass="50215" checksum="370C822EB349C53D" modified="2019-02-13" version="1">MSIARQVLNCSRFTCRSAHVTCRKTFTTSQHVMMSRHTHAKRIEGLDKNVWVAFTALAADPSVVNLGQGFPDIPPPSYVKEALAKAASVDRMNQYTRGFGHPSLVKALSQVYGKAYGRQIDPLKEILVTVGGYGSLFSAIQALVEEGDEVIIIEPFFDCYVPMVRMAGGKPVLIPLRLKSGKKTITSADWFLDPDELAGKFNSKTKAIIINTPNNPIGKVFTKDELQMIADLCIKHDTLCFSDEVYEWLVYRGHQHVKIATLPGMWDRTVTIGSAGKTFSVTGWKLGWSIGPEQLMKHLQTVMQNSLYTCPTPLQEAVAQGLLLNYELMDQPECYFTSLADELEGKRDRLAAIVEEAGMTPVIPEGGYFMLVDVTALNQDLSHMDEDEAYDYKFVKWMIKEKKLAAIPVTAFVGEESTKDFEKYIRLCFIKQDSTLDAARSILKSWTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTC5</accession>
    <name>A0A3P9BTC5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Dicarboxylate carrier UCP2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Mitochondrial uncoupling protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 25 member 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis, glutaminolysis and glutathione-dependent redox balance. Continuous export of oxaloacetate and related four-carbon dicarboxylates from mitochondrial matrix into the cytosol negatively regulates the oxidation of acetyl-CoA substrates via the Krebs cycle, lowering the ATP/ADP ratio and reactive oxygen species (ROS) production. May mediate inducible proton entry into the mitochondrial matrix affecting ATP turnover as a protection mechanism against oxidative stress. The proton currents are most likely associated with fatty acid flipping across the inner membrane of mitochondria in a metabolic process regulated by free fatty acids and purine nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(S)-malate(out) + phosphate(in) + H(+)(in) = (S)-malate(in) + phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:73299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-malate(out) = (S)-malate(in)</text>
            <dbReference type="Rhea" id="RHEA:74555"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>H(+)(in) = H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-aspartate(out) + phosphate(in) + H(+)(in) = L-aspartate(in) + phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:73307"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-aspartate(out) = L-aspartate(in)</text>
            <dbReference type="Rhea" id="RHEA:66332"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a long-chain fatty acid(out) = a long-chain fatty acid(in)</text>
            <dbReference type="Rhea" id="RHEA:39283"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>malonate(out) + phosphate(in) + H(+)(in) = malonate(in) + phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:73387"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>oxaloacetate(out) + phosphate(in) + H(+)(in) = oxaloacetate(in) + phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:73303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>phosphate(in) = phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:32823"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>sulfate(out) + phosphate(in) + H(+)(in) = sulfate(in) + phosphate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:73391"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer. Adopts an asymmetrical dimer of dimers functional form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 27">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549413.1">
        <property type="nucleotide sequence ID" value="XM_004549356.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004549414.1">
        <property type="nucleotide sequence ID" value="XM_004549357.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTC5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012861"/>
    <dbReference type="Ensembl" id="ENSMZET00005013305.1">
        <property type="protein sequence ID" value="ENSMZEP00005012861.1"/>
        <property type="gene ID" value="ENSMZEG00005009660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476128"/>
    <dbReference type="KEGG" id="mze:101476128"/>
    <dbReference type="CTD" id="7350"/>
    <dbReference type="GeneTree" id="ENSGT00940000160382"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071391">
        <property type="term" value="P:cellular response to estrogen stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000008">
        <property type="entry name" value="Mitochondrial uncoupling protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 26 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 27" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="26">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="26">
        <location>
            <begin position="110"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="26">
        <location>
            <begin position="209"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00054589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00074760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="306" mass="33629" checksum="9895D0D769A4B81E" modified="2019-02-13" version="1">MVGLKPSDVPPPLGVKMASAGAAACIADMVTFPLDTAKVRLQIQGEKKAVGDIRYRGVFGTISTMIRTEGPKSLYNGLVAGLQRQLCFASVRIGLYDNVKNFYTGGKDNPSVLVRILAGCTTGAMAVSFAQPTDVVKVRFQAQMNLDGVARRYSSTMQAYRHIFQHEGLRGLWKGTLPNITRNALVNCTELVTYDLIKEAILRHKLLSDNLPCHFVSAFGAGFVTTVIASPVDVVKTRYMNSPPGQYKSAVNCAWTMLTKEGPTAFYKGFVPSFLRLGSWNIVMFVSFEQIKRAMMVTKQRIEVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BUI6</accession>
    <name>A0A3P9BUI6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BUI6"/>
    <dbReference type="Ensembl" id="ENSMZET00005014046.1">
        <property type="protein sequence ID" value="ENSMZEP00005013587.1"/>
        <property type="gene ID" value="ENSMZEG00005010222.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161369"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050939">
        <property type="entry name" value="Olfactory_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24242:SF359">
        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="327" mass="36922" checksum="0623E24EDB5B5E6D" modified="2019-02-13" version="1">MSSQNTSINVTHFIIGGFDTLSRPIAVGVVILITYLLAVLANMANIMFIISDKRLHKPMYLLICNLAVVDIMYTSSCSPTMIGVLLAGVNTISCFPFGNINGCIIQMYVYQVGATMEMFSLTIMAFDRLIAIIYPLQYHSYLTNTRTLVFTYIVWIVACSFALFPPVTATPLPHCFLRLRYTFCDYGAVMRTTCVNPEKYFNQVAILSFFVSFFTFTFICLSYCGILFFVKILSNNDKKKMGSTLVSHLICVSCLYCPQFIIVILTRFGVVLTLEERQGLLIGTILGPSLVNPFVYCLRTKEIKSKMFKIFRKINTFLADNHFLAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVI6</accession>
    <name>A0A3P9BVI6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sosondowah ankyrin repeat domain family member C</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SOWAH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555597.1">
        <property type="nucleotide sequence ID" value="XM_004555540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVI6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013879"/>
    <dbReference type="Ensembl" id="ENSMZET00005014349.1">
        <property type="protein sequence ID" value="ENSMZEP00005013879.1"/>
        <property type="gene ID" value="ENSMZEG00005010457.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483297"/>
    <dbReference type="KEGG" id="mze:101483297"/>
    <dbReference type="CTD" id="100321117"/>
    <dbReference type="GeneTree" id="ENSGT00950000183003"/>
    <dbReference type="OrthoDB" id="60433at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058889">
        <property type="entry name" value="WHD_SOWAHA-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491:SF4">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25877">
        <property type="entry name" value="WHD_SOWAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SOWAHA-C winged helix-turn-helix" evidence="6">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="522" mass="56764" checksum="A7607E8773AD5D7A" modified="2019-02-13" version="1">MMMMASRCTVQAVQEFLSERGGRVQQMELIDHFLSLNEQSKEGVDREVLKSIVDSVGFVKVENGVKFVCLNSEGSGASVMRTDVDGHDGAECNGNIQETLDNNCVNGNHDKGDQTGVHFPLDNDKQTNGNKKPATPSQSKTSTGVPTPGGGGEVKLRDRRRRESAPVLGMPDLDQAQPGGSHNQQTRGARRVSRGSQRAMLTSCLSEDSALEGLDHIGDIQTPKGSRRNFIELMMSSSPQVRRSLINRGSRLRDSVKSEGDSTSLLSSATDEDCASVTLDPLEHEWMLCASDGLWDSLQPLLAVEPSLVTKRDFVTGFTCLHWAAKQGKAELLSQLLTFAKENTIPVNVNVRSSAGYTPLHLAAMHGHTQVVRVLLSDWDADPEARDYSGRRPMQYLSPPLAADLLEEGVVTSPGPESDSENNGSGRGRGWRFAKVLQGNLNPLRLLNSPTEASEDGTGNGKSKGGMQRKTSLSRLNARLHRGRHRAQIIHSASFRDTGEVGRGEELHSSPLRTRPLSNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVK2</accession>
    <name>A0A3P9BVK2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVK2"/>
    <dbReference type="Ensembl" id="ENSMZET00005014134.1">
        <property type="protein sequence ID" value="ENSMZEP00005013666.1"/>
        <property type="gene ID" value="ENSMZEG00005010291.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230358"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001648">
        <property type="entry name" value="Immunoglobulin heavy variable 4-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_V-set"/>
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        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="98" mass="11109" checksum="30576D733CEF6D47" modified="2019-02-13" version="1">EQLIQTASVTVQPGQRLTITCQVSYSLSSYWTAWIRQPAGKGLEWIGDAHYGHNTYYKDSLKNKFTINLDTSSKTVTLNGQNMQPEDTAVYYCARMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVV9</accession>
    <name>A0A3P9BVV9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Procollagen, type IX, alpha 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004547864.1">
        <property type="nucleotide sequence ID" value="XM_004547807.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVV9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014088"/>
    <dbReference type="Ensembl" id="ENSMZET00005014561.1">
        <property type="protein sequence ID" value="ENSMZEP00005014088.1"/>
        <property type="gene ID" value="ENSMZEG00005010617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482507"/>
    <dbReference type="KEGG" id="mze:101482507"/>
    <dbReference type="CTD" id="1298"/>
    <dbReference type="GeneTree" id="ENSGT00940000161290"/>
    <dbReference type="OrthoDB" id="8956848at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1100">
        <property type="entry name" value="FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018221269" evidence="2">
        <location>
            <begin position="23"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="691" mass="65107" checksum="C7679C9A4F0C797F" modified="2019-02-13" version="1">MAALSALLKTWVILQTLCLVLAQVRGPPGPPGPPGPPGPSGTPGSDGIDGEKGRPGSPGPPGQKGEPGEPGPDGSPGENGIDGLIGAKGDRGPIGRPGPKGQPGPTGEPGTPGPGLPGLAGIPGPIGLPGEIGPTGPKGILGPPGPPGFPGPPGKPGPPGKFIVGEEGSADFECPLNCPAGPKGPQGLQGVKGHKGRAGALGDPGSIGRPGPKGEVGISGEQGIPGPSGPMGLSGYPGMMGPKGEPGPGGYKGIGGPVGPPGPPGEEGPRGPPGEPGDKGDKGSRGIQGPQGAVGKKGENGLPGIDGKDGTPGIPGIKGGPGQAGMPGPPGPQGAAGLPGSPGAKGGPGAKGEPGPRGHVGLPGPSGPLGEPGIPGEPGMQGIPGPKGDRGERGPVGPQGAAGKPGSKGERGPIGVPGAQGLSGTKGDKGFQGKVGSKGGIGDPGVEGLAGEKGEKGLSGEPGPKGQQGIRGDTGHNGPTGDPGKPGDQGPLGLPGPRGLNGERGVPGMPGIQGPAGRDASDQHIVEVVLKMMQERLAAVAVSAKRAVLGGAGVMGSPGPPGPPGASGPQGPHGLPGARGIPGIIGAPGQIGNTGLKGKRGPKGVRGDPGRPHSGPPGAPGIQGPPGIDGVARDGRPGERGPQGTPGEAGRPGKSGPPGLPGFCEAAMCLAASAYTSPRLQEAGTIKGPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWH8</accession>
    <name>A0A3P9BWH8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 4 open reading frame 33</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0462 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538914.1">
        <property type="nucleotide sequence ID" value="XM_004538857.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWH8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014323"/>
    <dbReference type="Ensembl" id="ENSMZET00005014803.1">
        <property type="protein sequence ID" value="ENSMZEP00005014323.1"/>
        <property type="gene ID" value="ENSMZEG00005010784.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469318"/>
    <dbReference type="KEGG" id="mze:101469318"/>
    <dbReference type="CTD" id="100698946"/>
    <dbReference type="GeneTree" id="ENSGT00390000006284"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31475">
        <property type="entry name" value="UPF0462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31475:SF5">
        <property type="entry name" value="UPF0462 PROTEIN C4ORF33 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018120131" evidence="2">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="222" mass="25132" checksum="6A2D8E4B4B6B4555" modified="2019-02-13" version="1">MGVTRGLQFITLFHILLCCESLPRTQMQFDIEHTWDSNPVNHDPLKITFSPGLGGLKVEVSGPFFNDPAAPAGPPSQAFPGLWNYEVVETFFLDSTTENYLEVEFCPHGQHLILLLSGAGQAFLQQLPMVFNTKITGDRWTGEALIPWTYFPPNVNKMNSYAIHGSGENRIYEALYPIPKEEIAEGQMPNFHRLEYFKDFRLQSIMGEGWVQPPSDLWLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY65</accession>
    <name>A0A3P9BY65_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">S-nitroso-CoA reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme. Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione. Displays no reductase activity towards retinoids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-nitroso-CoA + NADPH + H(+) = sulfinamide-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:78375"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145546"/>
            <dbReference type="ChEBI" id="CHEBI:145548"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-nitrosoglutathione + NADPH + H(+) = S-(hydroxysulfenamide)glutathione + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:63500"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="RefSeq" id="XP_012774982.2">
        <property type="nucleotide sequence ID" value="XM_012919528.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BY65"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014807"/>
    <dbReference type="Ensembl" id="ENSMZET00005015295.1">
        <property type="protein sequence ID" value="ENSMZEP00005014807.1"/>
        <property type="gene ID" value="ENSMZEG00005011146.1"/>
    </dbReference>
    <dbReference type="CTD" id="799805"/>
    <dbReference type="GeneTree" id="ENSGT00940000156539"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046185">
        <property type="term" value="P:aldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19106">
        <property type="entry name" value="AKR_AKR1A1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044481">
        <property type="entry name" value="AKR1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="17">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="324" mass="36907" checksum="4FE90C06982274E9" modified="2019-02-13" version="1">MNDFAVLNTGRKMPLIGLGTWKSEPGKVKQAVIWALEAGYRHIDCASIYGNEAEIGEALQEKLGPEKSLRREDVFITSKLWNSKHHPDDVEPALLKTLKDLKLEYLDLYLIHWPYAFQRGDVTFPRKEDGTLLYDDTDYKLTWSAMEKLVGKGLVRAIGLSNFNSRQIDDILSVASVKPTVLQVECHPYLAQVELLAHCRDRGLVMTAYSPLGSADRAWKHPNEPILLEEPVISSLAEKYKKSPAQILLRWQTQRGVVTIPKSVTESRIKENIQVFDFTLEAEEMKSIAALTRGWRYIVPMIEVEGKRVPRDAGHPFYPFNDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYA9</accession>
    <name>A0A3P9BYA9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AU RNA binding protein/enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYA9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014626"/>
    <dbReference type="Ensembl" id="ENSMZET00005015109.1">
        <property type="protein sequence ID" value="ENSMZEP00005014626.1"/>
        <property type="gene ID" value="ENSMZEG00005011002.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157484"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF12">
        <property type="entry name" value="METHYLGLUTACONYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="299" mass="32503" checksum="5631175D9D0B3389" modified="2019-02-13" version="1">MAVLVGCRSFWQSFRVQAAHRQSACRLAAAFFSRRYVLSNRVVLCPRLNGHGAVTRYYSSDSKDDLRVRYLDGEDSGKFLSQPALPGMRMFEAVEDIKKNKKVRSVILCSLVPGIFCAGADLKERAKMHQSEVGPFVSKARALITELGSLPVPTIAAIDGAALGGGLEMALACDIRISCGTQRLPRVIGVSLAKELIFAARVVDGTQAQQMGLVSHSVEQNDSGDAAYLRALELAREINPQGPIAIRMAKLAINQGIEVDLSTGLAIEEACYSQVIPTKDRLEGLAAFKEKRQPHFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZ02</accession>
    <name>A0A3P9BZ02_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multidrug and toxin extrusion protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZ02"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015205"/>
    <dbReference type="Ensembl" id="ENSMZET00005015697.1">
        <property type="protein sequence ID" value="ENSMZEP00005015205.1"/>
        <property type="gene ID" value="ENSMZEG00005011367.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163234"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="555" mass="59635" checksum="A8D24DAE91C0CDB4" modified="2019-02-13" version="1">VKRICICSIMDSSGEKTGKCTEAVKEDLKESAAAACAQSSRGCCHICVPRFIPSVYRNELVQLSKLAGPVVISQFMIFMISFVSTVFCGHLGKTELAAVALSIAVINVTGISIGTGLSLTCDTLISQTYGSGNLKRVGVILQRGVLILLLACFPCWAILINTEPLLLAVKQSPEVASLSQLYVKIFMPALPVSLTGFDADLEGVQYLNKRQGIIWPQVITGAIGNVFNAIFNYVLIHQLDLGVAGSAAASAISQYLLASVLFIYMYLRGLHKATWAGWSLDCLQEWGPFAQLAVPSMLMLCLEWWVVEVGGFLAGVISEAELGAHLISYELTITAYMIALGFASAASVRVGNALGAGNIEQAKLSCKVPIICAFIIACFVSIIFGVSKDVIGYIFTSEPDILQRVSDLINLCLGVGKQSVGALCNLVGYYFIGLPTGVSLMFAAKMGVVGFWTGLTVCVFVQSIFFITFLCKLDWKKAAEEAEVRAGVRIKEEKDTIKMENRGEWANCQTTNTTTVGDVLSVSQLVVRRGLAILIMILILAAGVITNTVLTPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZV5</accession>
    <name>A0A3P9BZV5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SPARC related modular calcium binding 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004540041.1">
        <property type="nucleotide sequence ID" value="XM_004539984.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZV5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015444"/>
    <dbReference type="Ensembl" id="ENSMZET00005015942.1">
        <property type="protein sequence ID" value="ENSMZEP00005015444.1"/>
        <property type="gene ID" value="ENSMZEG00005011593.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483417"/>
    <dbReference type="CTD" id="64093"/>
    <dbReference type="GeneTree" id="ENSGT00390000018436"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002072">
        <property type="term" value="P:optic cup morphogenesis involved in camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000076">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000004">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF13">
        <property type="entry name" value="SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16597">
        <property type="entry name" value="Thyroglob_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018000345" evidence="11">
        <location>
            <begin position="29"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="13">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="12">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="12">
        <location>
            <begin position="279"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="317"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="508" mass="55907" checksum="7D728C0BD2CEBD48" modified="2019-02-13" version="1">MLLSSFLIFTVSYFMAPLFLCYLPQVSAQKPGSRWLIGDRDRDCGITCSRTGKPVCGSDGRSYDSNCELQKARCKDKTLTLAHRGRCRGKNWVLPVALAPTAISEGRDVELKDAGQSKCRVERNQALEQARRPQSSESMFIPECNEDGTFAQVQCHTLTGYCWCVTSDGKPVSGSSVHNRTPVCSGNFREFMGTHAGTSGLSGSVTDKPPGPPNTDRKVVSFRFFLTLNPDDGSKPTPTMETHVPPEGDEITAPTLWIKQLVYKENKKNSSSSRKPEKVPSCDQERQSALEEALQNPREAIFIPDCGPGGLYKAVQCHQSTGYCWCVLVDTGRPIPGTSTRYQTPECDGAARSRVSDTEEAFQGRELQGCPEGKKVEFITSLLDALTTDMVQAINSPAPSGGGRFVEPDPSHTLEERVVHWYFAQLDNNGSQDINKKELKPFKKYLKKKAKPKKCARKFTDYCDLNKDKAISLQELKGCLGVSKEGSSTTSGNQGTRQGTNLFIGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C1Q9</accession>
    <name>A0A3P9C1Q9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase TRIM21-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C1Q9"/>
    <dbReference type="Ensembl" id="ENSMZET00005016331.1">
        <property type="protein sequence ID" value="ENSMZEP00005015821.1"/>
        <property type="gene ID" value="ENSMZEG00005011876.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240400"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF32">
        <property type="entry name" value="BLOODTHIRSTY-RELATED GENE FAMILY, MEMBER 16 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="352"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="247"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="567" mass="64431" checksum="59B70D4D73F6A81C" modified="2019-02-13" version="1">MSAASCLLSKDRFLCSICLDVFTDPVSTPCGHNFCKSCISQHWDISDRCQCPLCKKVFQTRPELHINTFISDMVSQFRHEAQQKVSSSSSEQQAAKPGEVLCDICTGTKLKALKSCLVCLASYCQTHLEPHLTMKGLKRHQLIDPEENLESRMCMKHDKPLELFCKTDQTCVCMLCCVFDHKTHEFVPLREEYEVKKAELVKTEAEIQQMIIKRLLKIRKIKKSVKMSKDAADRKKAEGVQVFTALKESVDKRMNEFIKEIEDKQESTKKQAEGFITDLEQEISELMKRSSEVEQLSRSKDHLHLLQSFSSLKAAPTTKDWTEVSIHPPSYEGTVVRAGVRAVSQLKETLNKEMKKLFEAELKRVQQYAVDVTLDPDTAHPKLILSDDGKQVHCGEEENDLPDNPERFSEFLIVLGKQSFFSSGRFYFEVLVKGKTEWALGVVTESVNRKKKITPSPEKGYWTVGVYENICVAFEDPEVRLPLQSYPDKVGVFVDYEEGLVSFFDADHAALIYSFTGCSFTGKLYPFFCPGVNDDDNSAPLIICPVNQSVRSFSMRKSDQNQVNLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C263</accession>
    <name>A0A3P9C263_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pseudouridylate synthase RPUSD4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA pseudouridylate synthase domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544796.2">
        <property type="nucleotide sequence ID" value="XM_004544739.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C263"/>
    <dbReference type="SMR" id="A0A3P9C263"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015976"/>
    <dbReference type="Ensembl" id="ENSMZET00005016487.1">
        <property type="protein sequence ID" value="ENSMZEP00005015976.1"/>
        <property type="gene ID" value="ENSMZEG00005011999.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101484748"/>
    <dbReference type="CTD" id="84881"/>
    <dbReference type="GeneTree" id="ENSGT00940000158436"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000015">
        <property type="entry name" value="Mitochondrial RNA pseudouridine synthase RPUSD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF83">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="12">
        <location>
            <begin position="124"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="387" mass="43172" checksum="AC3E9B6BCB3496D6" modified="2019-02-13" version="1">MNSCGRLARVFDRRSGLDVLFCLAKPRTTCRQCPQTTPPLARGQSTAANHTPGSDADDKPRVRAVDLARKIRGEKSKTRETAPPMSAQQRRVMELKRFSVQLQNVHPNVLAKHLHRSVLYQDKDVVIVNKPYGIPVADDSDVTSITSVLPVLSKMMDGMKIKSDSQLIPCLGLEKDSTGTLLLARRDEVVEHVLALNRNNKVERKYWVITVGVPVPSEGLIDIPIIEREVTGPQPHYKMALSPLYRLNDEGDGVTKVRSHRQAHPALTKYRVLDSSSGCSLVELQPFTGVKHQMRVHMAFALGCPILGDHKYSHWSKLAPQKLPERVLGKLGIEQSKVRHLPLHLHARQLTLPGSSQADVNVSCPLPKYFTQTLGRLHITLPDEKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2M9</accession>
    <name>A0A3P9C2M9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2M9"/>
    <dbReference type="Ensembl" id="ENSMZET00005017026.1">
        <property type="protein sequence ID" value="ENSMZEP00005016503.1"/>
        <property type="gene ID" value="ENSMZEG00005012386.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183089"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000075">
        <property type="entry name" value="Histone H1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="6">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="138" mass="14289" checksum="3FD918D817C2B477" modified="2019-02-13" version="1">MTKLAVPKKVSLSVGELIVKAVAASKERNGLSVAALKKALAAGGYDVDKNKARVKTAIKSLVAKGTLVQTKGTRTSGSFKMNKATESKAKKPAAAKAKKPAAAAKKSPKKAAAALQPLARSQPHQRTIVRVAVTSLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7F7</accession>
    <name>A0A3P9C7F7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAB17, member RAS onco family</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559143.1">
        <property type="nucleotide sequence ID" value="XM_004559086.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7F7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018210"/>
    <dbReference type="Ensembl" id="ENSMZET00005018799.1">
        <property type="protein sequence ID" value="ENSMZEP00005018210.1"/>
        <property type="gene ID" value="ENSMZEG00005013677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474601"/>
    <dbReference type="KEGG" id="mze:101474601"/>
    <dbReference type="GeneTree" id="ENSGT00940000161839"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="227" mass="25350" checksum="3542A38CDDEC0F04" modified="2019-02-13" version="1">MGETLPRVHGGAQQYSDTLRRPVHTLRVKMVLLGSSGVGKSSLALRFSKDEFRSTSPTVGCAYLTQLVRLSNATLRFEIWDTAGQEKYHSVTPLYYRGAHVALLVYDITQRETFVRAQVWLKELEKQYIPGSTVIWLVGNKGDLAHNRQVPLEEGQSLASNKGLYFTETSALSGEQVTELLQSVAHRVFECIGAQQGGLTEWEEMPSVELQHRDSFNLFSSCCKVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8Q6</accession>
    <name>A0A3P9C8Q6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol polyphosphate 5-phosphatase type IV</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
            <ecNumber evidence="3">3.1.3.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">72 kDa inositol polyphosphate 5-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Inositol polyphosphate-5-phosphatase E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Phosphatidylinositol 4,5-bisphosphate 5-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25528"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="EC" id="3.1.3.86"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32955"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:32956"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22765"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts (when prenylated) with PDE6D; this is important for normal location in cilia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EC" id="3.1.3.86" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004566806.2">
        <property type="nucleotide sequence ID" value="XM_004566749.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8Q6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018648"/>
    <dbReference type="Ensembl" id="ENSMZET00005019248.1">
        <property type="protein sequence ID" value="ENSMZEP00005018648.1"/>
        <property type="gene ID" value="ENSMZEG00005014004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474548"/>
    <dbReference type="KEGG" id="mze:101474548"/>
    <dbReference type="CTD" id="56623"/>
    <dbReference type="GeneTree" id="ENSGT00940000158199"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09095">
        <property type="entry name" value="INPP5c_INPP5E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000039">
        <property type="entry name" value="72 kDa inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042478">
        <property type="entry name" value="INPP5E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46625">
        <property type="entry name" value="72 KDA INOSITOL POLYPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46625:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL POLYPHOSPHATE 5-PHOSPHATASE TYPE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="19">
        <location>
            <begin position="294"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="641" mass="71808" checksum="EFE4463188D2D729" modified="2019-02-13" version="1">MTEDGEDGPLHHSCEAPGKGDSIANDSSKLNTSIVDVKSTNGHKDDLRLRNTGEGISPYQPRPPLLPRLSKSSKSISLEETVRTRRLRNSQESLSDPAETGSSTDSLKEDETVVAPSGFVIQGTAAVRNERDPSARPHSAVPTGSPAFRDRGSSLSDYERRPRSQQSDLTVQQWRAAKVRLSPVQPTGPLPALEKSFASATLRAANRIDRDCLDYAMPAREKLGERLHRNLSDSRLLENMGSDSASVNSMRSTYSVLSPIRPQDMRNRSFMEGSVLGSGALLGAEELDRLFPDRRVGIYIATWNMQGEKGLPVNLDDLLLPTDSEFAQDFYVIGVQEGCPDRREWETRLQESLGPYYVMLYAASHGVLYLTVFVRRDLIWFCSEAEHATVTTRIISQIKTKGAVGIAFTFFGTSFLFVTSHFTSGDAKVYERILDYNKIVEALALPKGLPDTNPYRSTPSDVTTRFDQVFWFGDFNFRLDKDRSEVEAIISSTVGGDMSPLLEHDQLSKEMKEGSIFKGFQEASIHFLPTYKFDIGRDVYDTTSKQRTPSYTDRILFRSRQANDIKTLMYTSCSNIKTSDHRPVIGVFQVKLRPGRDNIPLCAGQFDRSLYLEGIRRRRITREIKTKEAMKNQSSTICTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9H2</accession>
    <name>A0A3P9C9H2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Nucleolar protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
            <location evidence="2 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544461.1">
        <property type="nucleotide sequence ID" value="XM_004544404.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9H2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018747"/>
    <dbReference type="Ensembl" id="ENSMZET00005019349.1">
        <property type="protein sequence ID" value="ENSMZEP00005018747.1"/>
        <property type="gene ID" value="ENSMZEG00005014058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468453"/>
    <dbReference type="KEGG" id="mze:101468453"/>
    <dbReference type="CTD" id="65083"/>
    <dbReference type="GeneTree" id="ENSGT00390000018619"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000005">
        <property type="entry name" value="Nucleolar protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000006">
        <property type="entry name" value="Nucleolar protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3030:FF:000001">
        <property type="entry name" value="Nucleolar protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="177"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="322"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="13">
        <location>
            <begin position="467"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="14">
        <location>
            <begin position="641"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="15">
        <location>
            <begin position="847"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="16">
        <location>
            <begin position="1004"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128237" checksum="DC47D0A7A8837645" modified="2019-02-13" version="1">MKKKQSVPEEPAEMNPSDSSRQREEDEENEAPVKAKRSKADHAGEEVVYHPVKLSRNDLYRPPTAEELNQLKEAESLFHCSLLKMQMEELLKEVALSERRKRQIDSFIQTVTKLIQTVPDSPEVEVSDLSWLSGAVKVPFLLVPKTTKGKFHMAPPSSIDLIGSYPLGTCTKPNVMVDLAVTIPNDVLHPKDVLNQRYPRKRALYLAGLAQHLTSSSDIGTMQYSCLHGNRLRPVLLLTPPGKDSSSFTLRVHACPAPGFFKPSRFHPQRNNIRTEWYTGLQTSQSESSEPPTPHYNSSVLGDLLPRAHLQFLSAVSSQCSAFTDGVALLKVWLRQRELDQGTGCFNGFLASMLLAYLLITHRISNSMTAYQLLRNTLNFLASTDLTVNGISLAKDPDSTAPSISEFHDAFQVVFVDPSGHLNMCADITACTYKQLQHEASLSMQFWDNPTVDGFQCLLMTPKPMIRTSDHVFQLCELVKLQSSCKKLNLLSELMDHSGDYIHTALPFILSLLQQGLSQRIHLLTHSLSPDPKWSVESEAPKHKAQPPLSFGLLLRTELSSSVLERGPPADSPKAAEFRQLWGPRSELRRFQDGDITEAVLWDGESICQKRLVPKQIITHLLQLHADIPESCVRYVGAMVDDVIKTGSEVSGTGEEESLVVVQSYDDLSRKLWRLEGLPLTITAVQGAHPALRYTQVFSPRPLKLEYSFFDREKTSRSLVPKEGKPCPVYITPITIICHMEGSGKWPHDRLAIQHIRAAFHIQLGELLRKHHSYTCRPCPTHLDVWKDGLVFRIQVAYHREPQVLRESLTAEGLLVVRDNDEAQALEMATIHKPLLTSTLHGLQQQHPCFGAACRLAKRWLSAQLFSDDITEDTADLLVASLFLQPAPFTAPSSPQVAFLRFLHLLSSFDWRNNPLIVNLNNQLTAVDYPEIKNGFMATRESLPVMFIATPKDKKLSMWTKRSPSIQMLQRVIMVAAESLKVLENQLIDGSQKQDVRVILRPPLDAYDVVIHLNPKQVPLLDQAVDPPAITFSRGVMSGSVAQPGGPLPVIDYNPVSLYLGELREAFGDLALFFCDPCGGTVITVLWKPKAFIPTPFKTSQVSARSVEVTGDEAKTVPNVEAILEDFRIMGKGLVKSVEARTEKWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAR0</accession>
    <name>A0A3P9CAR0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="2">PARP</shortName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019202"/>
    <dbReference type="Ensembl" id="ENSMZET00005019821.1">
        <property type="protein sequence ID" value="ENSMZEP00005019202.1"/>
        <property type="gene ID" value="ENSMZEG00005014412.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160555"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031273">
        <property type="entry name" value="PARP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058904">
        <property type="entry name" value="PARP4_MVP-ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058905">
        <property type="entry name" value="WGR-like_PARP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46530">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46530:SF1">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26156">
        <property type="entry name" value="PARP4_MVP-ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26166">
        <property type="entry name" value="WGR-like_PARP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="386"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="7">
        <location>
            <begin position="621"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="889"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1472"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1663"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1472"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1677"/>
            <end position="1687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1834" mass="201839" checksum="3464193A62A5B3A4" modified="2019-02-13" version="1">MAVFDNCSVLFELRGLSFKEKKTVKSAVTGHGGNLSFVVNKQCSLVVTTDVSNLSSNRLRSIQKHHTPVVGVDYVYRCVERGVLLQVDEYKLDTSSALSAPLHRSSFKAAPLASLAPQQIGSKGRAQPVECVSGTQRAESPERSGNVLDRFRIYRDTDSDLPSDQSDFQVAKYSIFEKVNSNSWCVLELQSFKGEEGRQYRVVRYWKDDILCGKKAVRDKLVFLSTSEEALEVFQALRDSLEASGLRRQSRFPPSACEMGSAPLQQLLLEEKLNTGSLSQEVGVFVELLWTEALGCLDNILRVSVDKLSLNDVSRAEGLLLQAQKKLTEGNHTELMSLLEDVYTLLPHRQLSIFPSTKLISQKLDLCQLIRDVLNASEMTLRSPAPSTVGKYRALRCSVETVPPSSSEFQAVTDLLQDSRVQIQQIVRVGRGVELQTFKSELGNVKPLLHSSSPNNFVGILSRGLLLPRVGVEHHGIERTDVGKLGGGIYFSDSLSTSLKYSKPGVTDGSRLLLVCDVALGRCRQVYRTDVLLKQAPDGYDSVRGVRRAPNTPSEFEDDEYVVYSPDQVKLKYVVQFSIQGDQLKAFTPAVDMSPELCLPCSAEELSLGDDMFESSKNPLEEVTAGLLDSAGQQLPLQAVHVKCKLMDLLSQVIIFQKYTNLSSVPIEAKYVFPLDDSAAVCGFEAFINGKHVVGQVKEKEKARKEYKQAIEKGHGAYLMDQDAPDVFTISVGNLPPGATVLIKVTFVSELIVRDGTILFSLPGSVAPWQESASLNQTTQVSVEKVCVTDEAASVREFTLDLSAEMPYEISSLQCITHQVKMKKTDCKAVVSVLPGQIMGPDGFQLSIMLSDVHLPRMWVEKHPDKDSQACMLVFYPDFEVSSSSDADEVILLLDTSESMKGESLRSARRIALQILKSLDRSLRLNVVFFGTDHTEAFLTVTPLGEVYEEAQRFIKHSAPLGGGTELWRPLRALSLLPPSRGIRNLLLLSDGHIQNTELTLKLLRDDAQHSRLFTCGLSTMANQHMLRALAQAGGGAYEFFDTKTKHNWAEKVACQLKRMASPGCSSVSVKWQQFSPTSPPLQAPKQLHALFNDCHTLVYGFVPHCTQATLLGNLSGQELKTMVSTSELQKTKGTFLHKLTARAVIRDYEDGNLDTSEAEHEGKKAELKSFIIELSKEFSILSQFTSFVAIEERDSEQPQPGFTDIPKLIAEEDVDFLPYINWISPEDDEDLIEAYSLEEDCGFDLFEICGSLTSPDSSPPAPPPSSFKELASMYSFSGHPAPPPPPSFMKCASDDVPHLSFLGHPAPPPPPSFKELASDDVPHLSFLGHPAPPPPPSFKEGASDDVPLLSFSRPPPPSFMKRASEGVSRLIPQGLSIPSSFCGYYPRSQSMDSFSFGISSSSDSQAVKDIDIPIFQSCSTQISRSSLHTQGYTSAMSNRVLSALDSVSDEEEQSSSVEGVSYRACKKPKKYKDGAARRPSFREQLPETSAPVDLEHQAKPHLQIYGQAGKRPEFKSKVFPEKSYLSPELCGLSTNGSLPDTAPAAVPSQVVVESDETAPLFVAQTARDRGPYFGSAKFTSSGFHSQLGSSSSTYDGAPGYTVVPVTSAPSDLEHQAKPDLCLRSLRRIRGRPCGRTTSYLASSLSPTCSDKDVPVSPARAPEKAAQLHRRGRAPSYSLSKVKSASQPHHELEAQSNVRQMFVAGHQDLPTNPVLRHQSAAPNAAESPEALKLKWMKIFQMQHSEGYWELTTELGELLNVNVDLFANVFLKNKGIHSLGVTAHKDILRLVATLLVLQLMKVDKLEEGKLLRTLFCLEEASQSRSVQHRMHNSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAR2</accession>
    <name>A0A3P9CAR2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with LGALS1 and laminin.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAR2"/>
    <dbReference type="Ensembl" id="ENSMZET00005019707.1">
        <property type="protein sequence ID" value="ENSMZEP00005019094.1"/>
        <property type="gene ID" value="ENSMZEG00005014324.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183145"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000002">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000009">
        <property type="entry name" value="WC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF27">
        <property type="entry name" value="SCAVENGER RECEPTOR CYSTEINE-RICH TYPE 1 PROTEIN M130-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018133452" description="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D" evidence="10">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="125"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="254"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="364"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="164"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="388"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="474" mass="51767" checksum="F6D41B241D5B2881" modified="2019-02-13" version="1">MVCCIHHISFMFFVLVFLDGAKIILTGSGSTRCSGRVEIYHNNNWVSVSEYNWDLNDAEVVCRQLNCGTALEAPRSAHFRAETEKIWLDNVNCSGNESSLNECQHSEFGRHKCGYDRSSFCSYLIRLAGSGSTRCSGRVEIYHNNIWGRVSDGGWDLNDAEVVCGQLNCGTALEVPQSAHFGAGTGRIWLDNVACSGTESSLTECKHSGFGSHSCGQGQDAGSFCSCVSYIKSFLYNVKNISKHFYALCLIDLIRLAGSGSTRCSGRVEIYHKYIWGTVSDYNWDLNDADVVCRQINCGSAVDALQLAYFGEGTGQIWLSDVTCSGNESSLTECEHSGWGNYYSGHYYDVGICNNLLHSLFSPIRLAGSTRCSGRVEIFHNKIWGTVCDNGWDLNDAEVVCRELNCGMALEAPRSAHFGAGTGQIWLDDVACSGKEGSLTECQHGGFGVNTCKHGEDAGVICSGEIHLDLLNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBH3</accession>
    <name>A0A3P9CBH3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBH3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019457"/>
    <dbReference type="Ensembl" id="ENSMZET00005020085.1">
        <property type="protein sequence ID" value="ENSMZEP00005019457.1"/>
        <property type="gene ID" value="ENSMZEG00005014609.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234537"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057667">
        <property type="entry name" value="HTH_SB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF135">
        <property type="entry name" value="SI:DKEY-77F5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25787">
        <property type="entry name" value="HTH_SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sleeping Beauty transposase HTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="3">
        <location>
            <begin position="149"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38959" checksum="32F7773023E406AE" modified="2019-02-13" version="1">MAKTKELSKDTRKSMVDLHQTGKSESTIGKQLGVKKSTVGAIIRKWKTYKTTDNLPRSGAPRKISSRGVKMIMRTVSKDPRTTRGDLVNDLQRAGTKVTKVTISNTLQRQGIKSRSARRVPLLKPVHVQARLKFAREHMDDTAEDWENVMWSDETKVELFGINSTRRVWREKNTELHPKNTIPTVKHGGGNIMLWGCFSAKGTGRLIRVKDRMNGAMYREILSQNLLPSVRTLKMKRGWVFQHDNDPKHTARATKEWLRKKHLKVLEWPSQSPDLNPIENLWRELKVRVAGRQPQNITALEKICMEEWAKIPATVCANLVKTYSKRLTSVIANKGYVTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDE7</accession>
    <name>A0A3P9CDE7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein family B (small) member 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDE7"/>
    <dbReference type="Ensembl" id="ENSMZET00005020691.1">
        <property type="protein sequence ID" value="ENSMZEP00005020044.1"/>
        <property type="gene ID" value="ENSMZEG00005015047.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010674"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46907:SF2">
        <property type="entry name" value="HEAT SHOCK PROTEIN BETA-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46907">
        <property type="entry name" value="HEAT SHOCK PROTEIN BETA-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="115" mass="12639" checksum="5293C0ACB3FFBDA9" modified="2019-02-13" version="1">MEKNGRNLSEDSGLLNQHSTREHKFTDHLQPTGKVQITGDIFQFTLDVSEFSPEDVIITSSNNLIEVHAEKLGEDGTVTNTFSHQCKLPSDVDPISLSMSMASGGLLTVRAHRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDS2</accession>
    <name>A0A3P9CDS2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="123" mass="13821" checksum="D4BD4616FD095465" modified="2019-02-13" version="1">MAVKPEFRKQFVDQVSDSTVNQLLDSLFQQGIINMEEMDSARIKPRADRARDVIDVVRNKGEEASSSLIDGLRELDPYLSETLHLTGEHLPHVSSFLHADDTQMILLVHPNQECLIVIVPAGE</sequence>
</entry>
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    <accession>A0A3P9CDZ8</accession>
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        <recommendedName>
            <fullName evidence="3">Sushi domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="132" mass="14898" checksum="7C8ADD2D9E23A486" modified="2019-02-13" version="1">MNRGKKLFDAHVAICGNKNIRSDFSKGSCPSPEFPQSSLNGDPKDACFQTGSAFSLTCIEDNARRAGISSLRCKESKGGPKWTKYLLQCIHKPYLFIVTRSKISRFWLARKTTLMTMNEHISTLFILKLVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEJ9</accession>
    <name>A0A3P9CEJ9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="102" mass="11519" checksum="9D967B92EB2FC131" modified="2019-02-13" version="1">MCSYLDIMSLPSAAWFLCTLLYPILKELQAERVTGEDGTEEKMLGFWSLLVLSVLVGCICCVFSWMFTYLDSFQPGMDFPTLRTVAHAVRNGWHVFRVTGVG</sequence>
</entry>
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        <submittedName>
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    </protein>
    <organism evidence="19 20">
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            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
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                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
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                <person name="Nishihara H."/>
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                <person name="Penman D.J."/>
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                <person name="Rakotomanga M."/>
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                <person name="Sharpe T."/>
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                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005020835"/>
    <dbReference type="Ensembl" id="ENSMZET00005021519.1">
        <property type="protein sequence ID" value="ENSMZEP00005020835.1"/>
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        <property type="component" value="LG10"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:cell-cell adhesion mediator activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:axon guidance"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CELL ADHESION MOLECULE DSCAML1"/>
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        <property type="entry name" value="Immunoglobulin"/>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
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    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="24"/>
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            <begin position="1072"/>
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            <begin position="1166"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1822" mass="200011" checksum="62B1D26A4837F005" modified="2019-02-13" version="1">LFSHTFTLLLIPLSFLLFGICHSIELPCIAGGYPSPTVRWLKDGRPLPSDARWTRRLTGLTISDLRQEDSGSYACEVTNSFGSKEVSGQLHVIDPLRVTLSPKNLKTGISSTLFFTCTVEGSPEYTITWYRNTEPIVPDEHISIQGQHNDTLQITAAQKLHSGAYQCFASRKGHTAQDFSIILLEDGTPRIVSSFSERVVNPGEPFSLMCAAKGAPPPSITWTLDDEPVIRDSTYKTSQYTLSDGLTVSHVNVSSPLIPDGGVYRCVARNSAGSAEYQARINVRGPPRIRPMRDITAVAGRNTYITCRVIGYPYYSIKWLKDGMQLPDNHRQVVFENGTLRLTDVQKGADEGTYLCSVLIQPQVSINQTVHVTVKVPPLIQPFDIPSTSVGKLMYIACVVSSGDMPIRITWHKDGQLIVPGSASGVAIETKEFMSSLQISNVTLKHNGNYTCIASNAAATVSWERQLIVTVPPRFVVQPNNQDCIYGKAGVLNCSVEGYPPPKVMWKHAKGVGNPQQYHPVPLTGRIQIMSNGSLLIRHVLEDDRGYYLCQASNGVGSDISKSMILTVKIPAMITSHPNTTMARKGQIKELNCTARGEQPIIIRWERGDTVIDAERNPRYSISINKKGDEVISTLKLNPAERGDSVFFSCHAINSYGEGRGLIQLTVQEPPDPPELEVREVKDRSMNLRWIQRFDGNSIITSYDIEYKNKSDTWDHMYTTRNISPTNNQANIVELHPACVYSIRMYSYNKIGRSLPSKELTISTEEAPPDGPPMDVILQPMTSQSIRVTWRAPKKELQNGVIRGYQIGYRENGPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSTEINATTLEDVPSEPPQNVRAISVTSDEAVITWAEPPRLTLHGVLKGYRVVFWSLFPDGEWGEMQNITTTREQVELRGLEKFTNYSVQVLAYTQAGDGVRSNVLYIQTREDLPGPPAGIKAVPSSSTSVVVSWLPPLKPNGIIRKYTIYCSSPGSGQPAPSEYEANPEMLFYRITHLTRGKQYLIWAAAVTTAGRGNISAKVTVEPAGKVPAKILSFGGTVTTPWMKEVRLPCSSVGEPTPTIKWTKDSEDSAIPVTADSQRQILSNGTLVLRLVKAEDSGYYTCTATNTLGFDTIIVNLVVQVPPDQPRLTVSTTSTSSITLAWIPGDNGGSSIRGFVLQYSVDNTEEWRDVFISSSERSFRLDNLRCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPVFNKDQPLLTHINSTHAGLNLQGWTSGGCPITDLMLDFRPKGTWAWQSLKANSTNQLFLSELREATWYELKMKACNSAGCGNQTSQFATTDYDGSTIPPIKSARGEGDDVKKLFSIGSPVILVTLGVALLFIIRKKRKEKSDKLKKYSLAEMLISKNNRSIDTPVKGPPQGPRLHIDIPRVQLLIEDKEGIKQIGEDKAAVPVTDTEFSQSVNPQNFCTGVSLHHQALIQNSGPLIDMSDIRPGTNPVSRKSIKSAHSSRNRYSSQWTLSRPSQSQSTASARTLTSDWRTMGSHGITATESDSYSASLSQDTDKGRNSMVSTESASSTYEELARAYEHAKLEEHLQHAKFTITECFISDSSSDQMTTGTNDPADSMTSLSTPSEPGICRFTASPPKPQDYDRGKNVAVPIPHRANKSEFCNLPLYMKTDPFFRKQGELHDPCPAVPPREASIRSLTQRAYHTQGRHKTLDPAKQQAQTLGHSGLGSLGASSGTATLPQRTLTMPSSNNAATASTSSTSSNPTNSNKVGGSRDSLLESSSSALGRLQKQSVGAYSKSYTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFU4</accession>
    <name>A0A3P9CFU4_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004541294.1">
        <property type="nucleotide sequence ID" value="XM_004541237.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CFU4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021150"/>
    <dbReference type="Ensembl" id="ENSMZET00005021847.1">
        <property type="protein sequence ID" value="ENSMZEP00005021150.1"/>
        <property type="gene ID" value="ENSMZEG00005015878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470552"/>
    <dbReference type="KEGG" id="mze:101470552"/>
    <dbReference type="CTD" id="790928"/>
    <dbReference type="GeneTree" id="ENSGT00940000157203"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000069">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017977897" description="RING-type E3 ubiquitin transferase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="340" mass="36598" checksum="14DD6E01B6E78DA2" modified="2019-02-13" version="1">MLGWRWTAAFGLWRTDVSVCAALGKMAEAAAVPPHRFFCHCCKGEVNPKLPEYICPRCDSGFIEEVTEDSSLLEVGANGLDDTATQFAELWHLLLVERPFTRDIDSPDSEPRLPGGRLGSFGDLGGLGGGPIGGSVPAGLGGSMGGLLGAGEHWGPGRPPRLSSQRRYRSRGSSRPDRSPAVEGIVQQFLAGLFANSGIPGSPPLSWTGMLHSNPGDYAWGQGGLDAVITQLLGQLENTGPPPAEKEKISSLPTVNISQEQADCCMECPVCKEDFRVGEPVRQLPCNHFFHSDCIVPWLEMHDTCPVCRKSLNGEDSSSQPPSESPSLSTDPRTQERWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGB4</accession>
    <name>A0A3P9CGB4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arpin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Arpin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004566208.1">
        <property type="nucleotide sequence ID" value="XM_004566151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGB4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021187"/>
    <dbReference type="Ensembl" id="ENSMZET00005021884.1">
        <property type="protein sequence ID" value="ENSMZEP00005021187.1"/>
        <property type="gene ID" value="ENSMZEG00005015899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481596"/>
    <dbReference type="KEGG" id="mze:101481596"/>
    <dbReference type="CTD" id="348110"/>
    <dbReference type="GeneTree" id="ENSGT00530000064251"/>
    <dbReference type="OrthoDB" id="5953051at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033058">
        <property type="term" value="P:directional locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051126">
        <property type="term" value="P:negative regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018889">
        <property type="entry name" value="Arpin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31199">
        <property type="entry name" value="ARPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31199:SF1">
        <property type="entry name" value="ARPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10574">
        <property type="entry name" value="UPF0552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="226" mass="25175" checksum="7230C3AD240890B6" modified="2019-02-13" version="1">MSRIYHNTSLQNKPVHSEKFDRAWCPSAFESGPGVLLEGKLLDVSRHAITDSNNQKVRFYVLYIQPSRIHQRKFDASGKEVEPNFSDTKKVNTGFLMSSYKVEAKGESDRLSEEQLSAAVNKAELMKITEKHRPAGTWAFWYPEADMEKTDLETGQAVRLKTRGNSPFVFSLARIDGGTVTKCNFAGDDKAGASWTDKIMANKSDTSSTRQPGGGGEGAEEDEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHB7</accession>
    <name>A0A3P9CHB7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dephospho-CoA kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561347.1">
        <property type="nucleotide sequence ID" value="XM_004561290.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHB7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021251"/>
    <dbReference type="Ensembl" id="ENSMZET00005021952.1">
        <property type="protein sequence ID" value="ENSMZEP00005021251.1"/>
        <property type="gene ID" value="ENSMZEG00005015957.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469768"/>
    <dbReference type="KEGG" id="mze:101469768"/>
    <dbReference type="CTD" id="79877"/>
    <dbReference type="GeneTree" id="ENSGT00550000075038"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000485">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="229" mass="25734" checksum="A3E4F6AA6C38C886" modified="2019-02-13" version="1">MYLVGLTGGIASGKSTVSSMLRELGCPIIDADVVARKVVEQRTRAYSCIVHHFGPGILLENGDIDRQKLGQIIFASEEKRKLLNSITHPEIHKAMLKEILFYFLRGYRYVVLDVPLLFETRRLTRFLNHTVVVYCDPATQLSRLMQRDGLTQEQAEQRVAAQMPLNEKRGLANHVIENSGGREDTHRQVLRLHTKLEDSMDFLLVRVIAIVATAGLGGLLLYAAKILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CI06</accession>
    <name>A0A3P9CI06_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptotagmin 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004566242.1">
        <property type="nucleotide sequence ID" value="XM_004566185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CI06"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021481"/>
    <dbReference type="Ensembl" id="ENSMZET00005022190.1">
        <property type="protein sequence ID" value="ENSMZEP00005021481.1"/>
        <property type="gene ID" value="ENSMZEG00005016137.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466676"/>
    <dbReference type="KEGG" id="mze:101466676"/>
    <dbReference type="CTD" id="90019"/>
    <dbReference type="GeneTree" id="ENSGT00940000160892"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000016">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000182">
        <property type="entry name" value="Synaptotagmin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF249">
        <property type="entry name" value="SYNAPTOTAGMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="128"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="259"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="426" mass="48129" checksum="59712BC4E41D90F2" modified="2019-02-13" version="1">MSKILPPQHSSHVKSNLLSKAKSFTVTDHPTTLISTYTNTTADPAVAFINGLLDRIPLPRWAIYTIFAAGGLLILLCCLCVCIKCCCKGKKKKKKNEQIDLKAVNGKTTTALVQPDVADVDYGSTKKQRGKLLYSLEYDGPLSELKLGIKQASSLMAMDLGGTSDPYVRVYILPEKSKTYETKVFRSTLNPVFNEQFTFQLPKSTLTKSTAVMKVFDFNRFSKHEIIGEIRVQLCNVDWNHIIEEWQELEAPAKFEEENLGEICFSLRYVPSASKLTVVILEAKNLKSMDVGGSSDPYVKMQLALDKRKWKKKKTSIKKKTLNPYFNESFVFDVSLDQIQRVNLVVSVWDHDAVTRNDPIGKIYLGCDATGNQLRHWADMLSNPRRPVAQWHSLLSAEQVNSTLTLKKKIPIPSKMKESAQQWYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CI33</accession>
    <name>A0A3P9CI33_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxidative stress-induced growth inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Monooxygenase catalytic activity. Involved in regulation of cytokinesis; promotes RHOA activity, probably acting locally at the midbody in late cytokinesis. Monooxygenase activity is involved in stabilizing transient structures between daughter cells, termed intercellular bridges, before abscission. Regulates differentiation and proliferation through the regulation of cell death.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the OKL38 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004548875.1">
        <property type="nucleotide sequence ID" value="XM_004548818.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CI33"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021958"/>
    <dbReference type="Ensembl" id="ENSMZET00005022678.1">
        <property type="protein sequence ID" value="ENSMZEP00005021958.1"/>
        <property type="gene ID" value="ENSMZEG00005016463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475239"/>
    <dbReference type="KEGG" id="mze:101475239"/>
    <dbReference type="CTD" id="393155"/>
    <dbReference type="GeneTree" id="ENSGT00390000006658"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000152">
        <property type="entry name" value="Oxidative stress-induced growth inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF15">
        <property type="entry name" value="OXIDATIVE STRESS-INDUCED GROWTH INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="533" mass="59047" checksum="FA18351BE7B03185" modified="2019-02-13" version="1">MDLHDKEILPGDILPVVIIGNGPSGICLSYLLSGYTPYLSPEASHPNPLLHSKLAEQPHLSLLEQDLEYLCEGLEGRSSNPVAVLFDSLLLPDSDFGFDHTSPLEWRYEPERAIPHLVLGKGPPGGAWHAMEGSMLTLSLANWMELPGLKLKDWMRDKRRNVRNDRATPAEIASYYQHYVSQMSLEQNFACGTLATSVTRQPISQEGSPPCWRVTGLQRREGEELGDGSTLSEEVPFSVLARNVVLATGTHDIPARLGAQGESLPFVCHSFWDLEAAIARGELDQSSDPVLVVGAGLTAADAVLATHHLNTPVYHAFRRSVNDPELIFNQLPKLLYPEYHKVHQMMTQQHQRNNSQQDHTQNLHRSNPSSSSSSLPRYPGYLSFPRHRVVEFRPDRKCVLESDAGERTVVQVSKALVLIGAHPNLSFLDNNGRSLGMNPEEPISCRRNPIEVDPFTNRVIAANGPGMYAMGPLVGENFVRFLKGGALAIASDLTKRQKEEAEKGEGELSIDRLMDRCVDRQTRADPEVCLVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CK36</accession>
    <name>A0A3P9CK36_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ heat shock protein family (Hsp40) member B5</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CK36"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022665"/>
    <dbReference type="Ensembl" id="ENSMZET00005023415.1">
        <property type="protein sequence ID" value="ENSMZEP00005022665.1"/>
        <property type="gene ID" value="ENSMZEG00005016965.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156090"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000005">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000007">
        <property type="entry name" value="dnaJ homolog subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF567">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="347" mass="39137" checksum="4B0EDD426DFB1C0D" modified="2019-02-13" version="1">MGKDYYKTLGIPKGSNEEEIKKAYRRMALRFHPDKNKDPSAEEKFKEIAEAYEVLSDPKKRVVYDQLGEEGLKTGGSSSSGPPGSSSYHYTFHGDPHATFASFFGGSNPFDINDTEQDAEMDEDDPFTHFGRQFGFPGGMNNGFPGEGRRRRGVPSERLGTNRKQQDPPVVHELKVSLEEIFHGCTKRMKITRRRLNPDGRSMRTEDKILNIVIKKGWKEGTKITFPKEGDETPENIPADIAFVLKDKGHAHFKRDGSNIIYNCKISLKEALCGCTVSIPTLENRVISLPCHDIIKPGTVKRLRGEGLPFPKNPSQRGDLIVEFSVRFPDRIPPQSREIIRQHLPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CL70</accession>
    <name>A0A3P9CL70_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CL70"/>
    <dbReference type="Ensembl" id="ENSMZET00005023310.1">
        <property type="protein sequence ID" value="ENSMZEP00005022561.1"/>
        <property type="gene ID" value="ENSMZEG00005016808.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167339"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
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    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:001155">
        <property type="entry name" value="Zinc finger 30C"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
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        <property type="match status" value="2"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000213">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMR2</accession>
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        <submittedName>
            <fullName evidence="8">Uncharacterized LOC101487004</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichliformes</taxon>
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            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
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    <dbReference type="Ensembl" id="ENSMZET00005024132.1">
        <property type="protein sequence ID" value="ENSMZEP00005023367.1"/>
        <property type="gene ID" value="ENSMZEG00005017490.1"/>
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    <dbReference type="GeneTree" id="ENSGT00400000025005"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF128">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="258" mass="27827" checksum="AE587862711C4D91" modified="2019-02-13" version="1">MAHEEKNPLPPAGTLSEGQRQSLFKMEPKTLGAIQIVIGILILCLSASVLQVHEVHFTGDVALFLIVVVQVTVSGSVLVHSGRRPTLFWVKCVLVLHLISAAFATAALGLMSKHLPYRQDSYHCEHCRKLELHAVQHCFRKCTGLIEQKCKLLIDGILGTLVIFLVLELLICITAMLFGLSVLAAGGSQTPSEGPVYPQTRPPPVPAVETVQAVQSARAAAEPTQVAVVVTEPDSEQVEDISTPPTEPQVEPIETAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CN30</accession>
    <name>A0A3P9CN30_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CN30"/>
    <dbReference type="Ensembl" id="ENSMZET00005024269.1">
        <property type="protein sequence ID" value="ENSMZEP00005023497.1"/>
        <property type="gene ID" value="ENSMZEG00005017581.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165756"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33198:SF19">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24106" checksum="4B9F3CE8B0EDBA70" modified="2019-02-13" version="1">MRVGRVEEYNESKEDFESYLERLEQRMLANDVSDEKKLCMFLSVIGADTFRLLKNLVSPRVPSTVGYAVLTEAFSAHYKPTPVVIAERFRFQKRNQKEADSVSDYVVALRQLSVMCNFEQYLDQALRDRFVSELRSDAVQRKLLLEMKSAGLGPRWRVGAVAGWLLCCLGLLLIPYPTLLLVTCSIMLYCGHLCAFCAEEFFCFLLSCCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPE2</accession>
    <name>A0A3P9CPE2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPE2"/>
    <dbReference type="Ensembl" id="ENSMZET00005024432.1">
        <property type="protein sequence ID" value="ENSMZEP00005023656.1"/>
        <property type="gene ID" value="ENSMZEG00005017697.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064692"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF7">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="577"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="642" mass="72347" checksum="E252F26B08C56CCB" modified="2019-02-13" version="1">MERGIEYDRAAFNTWKYRHYFEFDSLKSDKNISVRCTLCIGRKLISTSKNSTSNLSKHLAHCHKNVKLTENPQDPLTDVTAVATISTSTGQTSDGPTPAKQVKLDIRATGLSAAELKKLVAVYIVEDMLPISTVDSESFRRIVEKIPTKSGVKLPQRKSFVGYLEREYDKMNSNLKATLEEAEFVSTTADIWTVNNKSFMGVTVHWINSTLQRNKAALACKRIRGSHTYDVIGAEIEEIHSSYGLQGKVIATVTDNASNFAKAFRVCQPCHLESESENEEGDDEEPTFTDVIEALSAASGDAQFSLPPHYRCASHTINLISTSNVDKHLNSCADTKAVYRSSIAKCSALWTKASRSTLASEQVEEVSRRKLMVPTSTRWNSLYEAISRIITIPLNELNPLCVKLGIKCLNEREYQFLKEYCTVMKPLTVALDILQGDECTYRALLPTLTSLMSKTLALKDDLSRMTASLPDVIVKAIKTRFDAVLDSQEGLLAVATCPKFKLRWLRDERRREYVKELLITECRKAAPATENTNVSQIPASPAEMDFFEFQNQPTESFSAEKEVTDFLRSGYELEILNQFPNLKKMYMKYNSPTPSSAPVERLFSLGGLVLSPKRNRMSDRRFEKLLLMRYNHCFSPKENNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRD5</accession>
    <name>A0A3P9CRD5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="CLECT_DC-SIGN_like"/>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
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        <location>
            <begin position="25"/>
            <end position="139"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="142" mass="15932" checksum="1182B50F60F8FC53" modified="2025-10-08" version="2">MLPNRAHFIHNVVNPSPLCIHDLNPGCSCYLLSESSASWDAARKNCRDRGADLMVVDTPKEQVLCLSAAWIGLTDEEQEGTWKWVDGTPLTLMYWAGDQPDNGGGSSYWGEEDCVHVRTDTKKTWNDRSCSTSLKWICEKNP</sequence>
</entry>
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    <accession>A0A3P9CRL6</accession>
    <name>A0A3P9CRL6_9CICH</name>
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        <recommendedName>
            <fullName evidence="4">Plac8 onzin related protein 6</fullName>
        </recommendedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the cornifelin family.</text>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17903" checksum="2FB20BAD99C8D5A0" modified="2019-02-13" version="1">MAIAGKPLPDWDSDVLGCCQDMKTCCYGFWCCPCLACTVSGNFGENSCLPLCDICGPGILAACGIPICVPPAVLSLRAGMRNRYGIKGSLCKDIVLSCFCEWCSWCQMHRELKHRKKNPTVITIQNNPVVSMQPIPTVQPAMMMMPAQPVATGFVSQPTVVIQTK</sequence>
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    <accession>A0A3P9CSD0</accession>
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        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="Streelman J.T."/>
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        <scope>IDENTIFICATION</scope>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024726.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="64" mass="7600" checksum="3D9B1F336331DBDD" modified="2019-02-13" version="1">MGKDFSLFKKEFLHTHNAYRAQHGAPPLTFNTELDDAAQKWANQMLAKKKLETHRYAFSWAWFK</sequence>
</entry>
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    <accession>A0A3P9CSG8</accession>
    <name>A0A3P9CSG8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin type III domain containing 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>African cichlids</taxon>
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            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
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    <reference evidence="2" key="1">
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSG8"/>
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        <property type="gene ID" value="ENSMZEG00005018888.1"/>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 7"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="198"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="283"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="369"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="537" mass="56788" checksum="5FB76C5AAE53FCA3" modified="2019-02-13" version="1">MAVNTAGRSQPSIPVTGKTVLAPPQLASSSTSNSSIVLSWDPVAHAVQYTVSICKLDSNISMGVYNTSNTSLTFSGLDAGSLYVITCFAWDLEGRKGDSSNIKQATRPRTPASVNVSVVMNGSVAGLLVSWEPDQEVYGPIEYNVMSDLNLMCKTTSSSCTLSVVGCGEVHTIQVTASNEAGPSYPSSPAVFITFPCPPESLALVESSEGNCTLTWKTVAHADSYMALIETAGSSVETCNTTSNNCTFHCPCGQTYLLSVLAFNHAGSSPQGQVLNYTTLVCCPEDVSVSAVSTDTLDIRWMPSRGAVLYETRAAHSSEVILCNDTAPMCVLSGLSCDTAYSVVVIPCNDVSGCNLACKAHTKDTAPCMPNNVMLNPKNSSCVTVSWTANNRAANYTVSANGDDDKHICSTNKSSCDITDLSCGSTYEVSVEATSTAGPSLPSYSEFLETEPCCPVNLTVDQVTQAITNVSWSHAKGARLFIATLTSSRGHARCHTQDSHCLMGCITCSTNYTVTMEAISHNGRRSNCTYQGFSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUS2</accession>
    <name>A0A3P9CUS2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 135</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550075.2">
        <property type="nucleotide sequence ID" value="XM_004550018.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUS2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025814"/>
    <dbReference type="Ensembl" id="ENSMZET00005026648.1">
        <property type="protein sequence ID" value="ENSMZEP00005025814.1"/>
        <property type="gene ID" value="ENSMZEG00005019254.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101472118"/>
    <dbReference type="CTD" id="65084"/>
    <dbReference type="GeneTree" id="ENSGT00390000000303"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="457" mass="51932" checksum="8AAE9E036422B530" modified="2019-02-13" version="1">MAALSKIPHNCYEIGHTWSPSCVQSAADVTRSALEVSFKIYAPLYLIAAVLRRRKKDYYLKRLIPEIFWSTSFLTTNGGLFIVFFCILRRLLGGFYSWSVGFGSALPASYIAILLERKSRRGLLTIYMANLATETLFRMAVTRGVVKPIKHGEVLLFCITSSLFMFFFRSKDGLKGFAFSALKFIIGKEEIPTHSVLADDSQPSAERPDSRRKTLLSSTRKLLESICKRGPRHRCCKHYNDNCISYCVKGFVRMFSVGYVIQCLLKVPSAFRQMFSKPSRLPSLFYNKENFQLGVFLGSFVSIYKGTSCLLRWMRNIDDELHALIAGFLAGVSMFFYKSTTISMYLFSKLVETIYFKGIEAGRLPYIPHADTIIYAVSTAICFHAAVMEVQNLRPAYWKFLLRLTQDRFALMNRQVLDMFGTQASRDFKGFVPKLDPHYTTVPSKTVLLPGGDIQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVA3</accession>
    <name>A0A3P9CVA3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Notchless protein homolog 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVA3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025756"/>
    <dbReference type="Ensembl" id="ENSMZET00005026589.1">
        <property type="protein sequence ID" value="ENSMZEP00005025756.1"/>
        <property type="gene ID" value="ENSMZEG00005019212.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157881"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000129">
        <property type="entry name" value="Notchless homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="535" mass="59442" checksum="84511541461FB76F" modified="2019-02-13" version="1">MEKEVARLLPIIHCVNPLTDVIFDDFFTYLSFKGSVVVHTWESLSRRYRSKGGPEADMSSEDVERLLIQFQDENGEILGSPFDVPLDITQDKLQLVCNALLQKEEPVPLAFFVQGEMEVVSSLGTCVKALGVETEQVLPVVYQPQALFRVRAVTRCTSTLQGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLTTETPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQICLWDPVTGAQIGRTLTGHTKWITWLCWEPLHLNPECRYLASSSKDGSIRIWDTVLGRCEKILTGHTQSVTCVKWGGDGLLYTSSQDRTVKVWRAKDGVQCRTLQGHAHWVNTLALSTDHVLRTGAFEPANATVNPQDLTGSLEELKEKALERYNKVRGSAPERLVSGSDDFTLFLWNPAQDKKPLARMTGHSALVNEVLFSPDTRLLASASFDKSVKIWDGRTGKYLMSLRGHVASVYQIAWSADSRLLVSGSSDSTLKVWDIKSGKLNMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVJ6</accession>
    <name>A0A3P9CVJ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13186"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVJ6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026007"/>
    <dbReference type="Ensembl" id="ENSMZET00005026846.1">
        <property type="protein sequence ID" value="ENSMZEP00005026007.1"/>
        <property type="gene ID" value="ENSMZEG00005019394.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009083"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000260">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000003">
        <property type="entry name" value="porphobilinogen deaminase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="16">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="17">
        <location>
            <begin position="244"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="360" mass="39518" checksum="0FDAA2B5AEB32246" modified="2019-02-13" version="1">MEEGPYKYIRDGNGKVSRVIRVGTRKSQLARIQTDSVAETLKELYPDIHLEIVAMSTTGDKILDTALSKIGEKSLFTKELENALERNEVDLVVHSLKDLPTTLPPGFTIGAVLKRENPHDAVVLHPSHAGKTLDTLPENSVIGTSSLRRAAQLKKRFPHLDFKDIRGNLNTRLKKLDEKKDFAAIILAAAGLRRMGWESRISQILEPDDCMYAVGQGALAVEVRARDADILEMVSILHDPDTVLRCIAERAFLRRLEGGCSVPVAVHTQVKDSQLYLTGAVYSLDGSNSLKETMQVSIAVGTQSSEKVDEQVQRVGVTANKIPGSVQDEAEKLGVDLADLLLSKGAKEILTVARQLNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D117</accession>
    <name>A0A3P9D117_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D117"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027786"/>
    <dbReference type="Ensembl" id="ENSMZET00005028670.1">
        <property type="protein sequence ID" value="ENSMZEP00005027786.1"/>
        <property type="gene ID" value="ENSMZEG00005020718.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164472"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="215"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="455" mass="50961" checksum="B7CA543DF15E552F" modified="2019-02-13" version="1">MWSLGLVAVELATGVPLYPGEDDYDVLKFIIETQGQLPDHLLESGLYTDSYFIEDNHKEQRWTFKTPEQFQYETDYRSKETRSIKLKCLDDLEQLLKVRRGPENGQTLFVRLIKEMLALDANQRVTPSEVLKHPFFHPGLSRTTPCTDMNSTGGELLVLSQQPSSWKSHGSQKFSCSFQNSVEFPQKGDINTSANPSASEDDLQITEGTILGDHHVVEAFLGEGGFGLVTRCRDTKNNKTVAIKVNKSDPEILLQLRRLDPDRCNIVEWNGYFLDGQRICLNFELLDQSLWDYIGDRNNRGLPMRELRPILHQVANALFHLGSVGIVHADLKPGNIMVVNHSESPVKVKLIDFGLACPASAVIPGDRVGTIGYCAPEVMLGIPYNEAIDMWSLGLVAVELATGVALYPGEDDYDVLKFIIETQGQLPDHLLESGLNILNNIQSIIYKITSTRVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D137</accession>
    <name>A0A3P9D137_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D137"/>
    <dbReference type="Ensembl" id="ENSMZET00005029202.1">
        <property type="protein sequence ID" value="ENSMZEP00005028303.1"/>
        <property type="gene ID" value="ENSMZEG00005021105.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263473"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER K-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="153" mass="17601" checksum="F5D0352007790260" modified="2019-02-13" version="1">MTFLGRNMRPDFLLLLSFFVSHQQYHFINKSLTWYEAQSFCRLKYTDLATINDMDDENQLINTLGGNVTSSWIGLYDGQINRWLWSDGSGIASFTQWSPGEPNNAGGIESCGEMYDSLWNDAPCGFAMAYVCYESERGSFKCIHIYEYILYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1C4</accession>
    <name>A0A3P9D1C4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CD209 antigen-like protein E</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540734.2">
        <property type="nucleotide sequence ID" value="XM_004540677.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1C4"/>
    <dbReference type="Ensembl" id="ENSMZET00005028794.1">
        <property type="protein sequence ID" value="ENSMZEP00005027906.1"/>
        <property type="gene ID" value="ENSMZEG00005020810.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101466187"/>
    <dbReference type="GeneTree" id="ENSGT01030000234575"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="177"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="310" mass="36053" checksum="B11E7F3FBA6E88A7" modified="2019-02-13" version="1">MEERREPTGGNFNGGFKEFICEEDFYDEEHPHHHQSNRHQVSMFTMSPGRCHRLAAVSLALLAAVLLIVDIGLGVHYNKLTDTHLTLDDTERISKELINLQDTYKTAVEIMKDARKQLDSEMSRQTQTNWELEHQTKRSNDYKSQMEKITKEIETSRSRLSMHSDGCKRCPVGWILMNSVCYYFSLKSNEMKTWKESRDFCQLQGGDLIIIDSQDKENSTVNFLINHQDASQLSTDFWIGLSDSKEEGTWKWLDGRFLVQGYWNDGEPNNLNDEDCAAVYPRVNFFKAWNDVRCGVRRKWICEKAPESMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2S9</accession>
    <name>A0A3P9D2S9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Receptor-interacting serine-threonine kinase 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D2S9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028406"/>
    <dbReference type="Ensembl" id="ENSMZET00005029310.1">
        <property type="protein sequence ID" value="ENSMZEP00005028406.1"/>
        <property type="gene ID" value="ENSMZEG00005021179.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160206"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF297">
        <property type="entry name" value="RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="326" mass="36246" checksum="AA4D6DF1216AF9E3" modified="2019-02-13" version="1">MALHSSPTHAEIGDSDLDDWEVKGSGGFGQVYKARHQMWCCDVAVKLLHDDDGTSSSLLREVRMMCKGSSPYVIPVLGVFKGHSPSFGPVKLGLVMEFMERGSLANLQRTLQGPPPWPLAFRLTHQVALGINFLHNLSPALLHLDLKPSNVLLDSFLNAKLTDFGLAKFSQSVTRKSKKYSDEEEGGTISYMPPEAFSISYNPTRASDIYSYGILLWSIVTGKEPYPHALSSIVRLRIPQGDRPSLDEIRCLAAGRAGLARLMELMQKCWEAKPAQRPTSHVCTIVTEELYKMHKRAIIDAVHGVLKKLVRDKPLVFIDISNFVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D5T1</accession>
    <name>A0A3P9D5T1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cystatin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Stefin-B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D5T1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029456"/>
    <dbReference type="Ensembl" id="ENSMZET00005030384.1">
        <property type="protein sequence ID" value="ENSMZEP00005029456.1"/>
        <property type="gene ID" value="ENSMZEG00005021970.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155717"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071220">
        <property type="term" value="P:cellular response to bacterial lipoprotein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000001">
        <property type="entry name" value="Cystatin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF21">
        <property type="entry name" value="CYSTATIN 14A, TANDEM DUPLICATE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018217767" description="Cystatin-B" evidence="9">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="10">
        <location>
            <begin position="56"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="153" mass="17552" checksum="39F8E9BA1EEDA81F" modified="2019-02-13" version="1">MMVRSKMCLCGVFFFFSLQTNASFSVRWSKMRSLVNWRVFITFLVVFYQQNVVGVKMIGGLTEEKQADEAVQKICDAMKPLAEQKTGRNFEVFTAESYKTQLVAGTNYFIKVHVGGGEYVHLRVYKKLPAYGGTLQLTRLQHPKSQHDTIAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D712</accession>
    <name>A0A3P9D712_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homologous-pairing protein 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PSMC3-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome 26S ATPase subunit 3-interacting protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552315.1">
        <property type="nucleotide sequence ID" value="XM_004552258.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D712"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030358"/>
    <dbReference type="Ensembl" id="ENSMZET00005031311.1">
        <property type="protein sequence ID" value="ENSMZEP00005030358.1"/>
        <property type="gene ID" value="ENSMZEG00005022623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472549"/>
    <dbReference type="KEGG" id="mze:101472549"/>
    <dbReference type="CTD" id="29893"/>
    <dbReference type="GeneTree" id="ENSGT00390000006890"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000394">
        <property type="entry name" value="Homologous-pairing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="11">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="12">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="81"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="212" mass="24121" checksum="FB6372230898E423" modified="2019-02-13" version="1">MSKKDNGAGVILAYLNEKNRPYSAQDVFSNLQKQHGLGKTAVVKAMELLALEGKIKEKIYGKQKIYFADQAQFKDVNDADLKAIDHQISELSEEVQSLTQSCRQLDAELKELNSSLTTEEMVSEIQELKAECSGYRARLEKIKSASNHITPEEKDKVYKERDLYVKEWKKRKRLASDMTNAILEGYPKSKKEFLEEVGVETDEDCKVVPPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8B2</accession>
    <name>A0A3P9D8B2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Homeobox B5</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004568700.1">
        <property type="nucleotide sequence ID" value="XM_004568643.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8B2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030940"/>
    <dbReference type="Ensembl" id="ENSMZET00005031931.1">
        <property type="protein sequence ID" value="ENSMZEP00005030940.1"/>
        <property type="gene ID" value="ENSMZEG00005023055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463796"/>
    <dbReference type="KEGG" id="mze:101463796"/>
    <dbReference type="CTD" id="30317"/>
    <dbReference type="GeneTree" id="ENSGT00940000158354"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000055">
        <property type="entry name" value="Homeobox protein Hox-A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="234"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="309" mass="33063" checksum="A01D9A59C1FFAC0A" modified="2019-02-13" version="1">MSSYFVNSFSGRYPNGPEYQLLNYGGSSGAMNGGTYRDSSSATMHPATGSYGYSYNGMDLTVTNRGGGTNSTANAGGHFGGGSVGGDSRGFGSPAPDRGFRQPSSCSLASAADSLLSPGNESTKLGARSSSPRSDQAGSGNLSSPNLSSASSTGGGGTVQRFTELDDASPEIEDLQHNRDTSHASNPPPRTGHKQEGGPTGSAAGNTGSEAQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8F2</accession>
    <name>A0A3P9D8F2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable E3 ubiquitin-protein ligase ARI7</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_024657528.1">
        <property type="nucleotide sequence ID" value="XM_024801760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8F2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030985"/>
    <dbReference type="Ensembl" id="ENSMZET00005031983.1">
        <property type="protein sequence ID" value="ENSMZEP00005030985.1"/>
        <property type="gene ID" value="ENSMZEG00005023097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="112433743"/>
    <dbReference type="KEGG" id="mze:112433743"/>
    <dbReference type="GeneTree" id="ENSGT00510000050415"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000040">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIAD_supradom"/>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="266" mass="29910" checksum="A7B36049CF2C887E" modified="2019-02-13" version="1">MSSISKTKEEKCYNSTFNLVDREDELDIYCEGFASGRALMSCGHAVTPSSLTNYCLRLLEKGEINFVCALPGCDIIWSYGEVCKMALLTPEEKEYFGQTMTLNAMKHRFDYKLCPGCSSCVVRKDVSNLSVCCSWCSKEKDRTYEFCWQCLKEWKGPRPRSDRCDNVGCSNETLQILKNCEDIIFESVNNVSGCPCIRACPTCGVLVEHNKNKCKNIVCPTCKKEFCFVCLKLTSECAGKRGMYSGPCADGMVAPRQTSIPTWQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8S9</accession>
    <name>A0A3P9D8S9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8S9"/>
    <dbReference type="Ensembl" id="ENSMZET00005031965.1">
        <property type="protein sequence ID" value="ENSMZEP00005030973.1"/>
        <property type="gene ID" value="ENSMZEG00005023081.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234557"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051287">
        <property type="entry name" value="TCR_variable_region"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367:SF18">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0675">Receptor</keyword>
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        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="121" mass="13495" checksum="3E183C00EBDCD2F3" modified="2019-02-13" version="1">MCLGMNTTLAQKDNVLQAKGEETTAAGGTVTLGCLYNVSITTNHYLFWYKQDGNNSPKFILSRFKVGEGKTEAGDRFSSTLDSSIRSVPLKIQKLQLSDSAVYYCALHLLGYRLHSFSWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D984</accession>
    <name>A0A3P9D984_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Scavenger receptor cysteine-rich type 1 protein M160</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D984"/>
    <dbReference type="Ensembl" id="ENSMZET00005032271.1">
        <property type="protein sequence ID" value="ENSMZEP00005031260.1"/>
        <property type="gene ID" value="ENSMZEG00005023307.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163299"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000013">
        <property type="entry name" value="CD163 molecule like 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF22">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="6"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="110"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="205"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="406"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="501"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="605"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="856"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="866"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="884" mass="95997" checksum="364E078A1399D078" modified="2019-02-13" version="1">MSPDSVRLLNGSSLCSGRLEVKSDQSWSSVCEADFDQQDAEVVCRELGCGPPSVLQGVLYEEVEAPVWSKEFQCGGHESALLDCRSSGSARNSCSPGKAVGLTCSEPDDVRLVGGANNCEGMMELRHLGEWRTVSAFSWTLKDAAFVCKHLDCGSAVSVDSRHESLKRPAWWIKYDCVHVRSALKDCTASSYHSFILNITCSESVRLGGASRCVGTVELKHQGEWRPAIDYDLRKAAVLCKHLDCGSAVSAVIRPKSSPADVLGISSDCFQSGTTRSECAAPKASNYTLDLICSDLLVQPIIQASSMDGVYEAQEQGLTVSRHSNFTISCSIQPQYPGGSFQLTFNSTNTAYSYTQPAVNHSAHFLFPAAVPAHQGNYSCVYHIYVFSHNFTAESHLLPVTVSEFVSLVGGPSRCAGTLELKHLGVWRPMDSSDWTIKAASVICEHLDCGSAISVEWREDSTEKSVWKIQDGCIESGSAIKECLQLRLSSFSLYLTCSDSVRLLNGSSLCSGRLEVKSNQSWSSVCEADFDQQDAEVVCRELGCGPPSVLQGALYGEVEAPVWSKELQCGGHESALLDCRSSGSARNSCSPGKAVGLTCSEPHDLRLVGGASRCAGSLELKLGDWRPVEASEWILGKAAVICEHLHCGSLDYVEARNESLLRSVWRLKPDCVQSGCALRECVTSEYSLMIMNFTCSDLLVQPNIHASSMDGVFKAQQQGLQVSSRSNFTISCSIQPQYPGGSFQLTFTSSNTAYSYTQPAVNHSAHFLFPAAVPAHQGNYSCVYHIYVFSHNFSSESRQLSVAVSPPAAPTVHTITGVILLLILLIVITALYFCWKASREQTLSRKDTDVVYYNYSDHGEGGSAEDESRQGGEEDLKEAHLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCF6</accession>
    <name>A0A3P9DCF6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Immunoglobulin subtype domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCF6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032370"/>
    <dbReference type="Ensembl" id="ENSMZET00005033414.1">
        <property type="protein sequence ID" value="ENSMZEP00005032370.1"/>
        <property type="gene ID" value="ENSMZEG00005024118.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000203939"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF80">
        <property type="entry name" value="IMMUNOGLOBULIN V-SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018160260" description="Immunoglobulin subtype domain-containing protein" evidence="5">
        <location>
            <begin position="27"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29936" checksum="4DA9B8041A072988" modified="2019-02-13" version="1">EAKNATFKVILTVLTFGLQHVFVLHGNDLHLDTEKPFKLEEQTDLFWRFNSSNNIAKCVFNKDPVVYIKYAGKAEVFGQNYSLKLKNVQHSDSGDYKAVVVSEQEQRVAEYKVIVQDPVTAAKLTVESVSKSSDSCNLTVTCSTVDFNISSSFRCDGKICSHAEEKDLKATKEFSSLSVYLQQDTIYCNHSNQVSWNQTMKVLKSYCETETGENKDLLCDVCMLSPCLITYLWIVIESTHNPVQILELSPHCSDTQHQTIHNTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCJ0</accession>
    <name>A0A3P9DCJ0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HBS1-like translational GTPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCJ0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032243"/>
    <dbReference type="Ensembl" id="ENSMZET00005033286.1">
        <property type="protein sequence ID" value="ENSMZEP00005032243.1"/>
        <property type="gene ID" value="ENSMZEG00005024018.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156274"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000035">
        <property type="entry name" value="HBS1-like translational GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018202138" evidence="10">
        <location>
            <begin position="19"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="156"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="582" mass="63810" checksum="DAB4443097BC2389" modified="2019-02-13" version="1">MSFSLANISILTLILVHAQKSLDVSNHSGKKTNGKTFSPWRKCESWRPLFAFLCLLFFSAKSRDASHNKLDSEVLPKVARMTVSGKRQTMGFDVPSTGENGVVVTATEAASKRPETPSKGSNGDEPMTGPTLSRSSGKARQAINIKAELEKRQGGKPLLNLVVIGHVDAGKSTLMGHLLYLLGNVNKRTMHKYEQESKKAGKASFAYAWVLDETGEERDRGVTMDVGMTKFETNSKVVTLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFEAGGQTREHALLVRSLGVTQLAVAVNKMDQVNWQQERFQEIISKLGHFLKQAGFKESDVFYIPTSGLSGENLATRSSVSQLTSWYSGPSLLEQIDAFKAPQRSVDKPFRLCVSDVFKDQGSGFCVTGKIEAGYIQTGDKILAMPPNETCTVKGITLHDEALDWAAAGDHVSLTLTGMDIIKINMGCVFCDPKEPIRVCTRFRARVLIFNIEIPITQGFPVLLHYQTVSEPATIRKLISVLHKSSGEVLKKKPKCLSKGMNAIVEIQTQRPVSLELYKDYKELGRFMLRYVGSTIAAGVVTEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFM6</accession>
    <name>A0A3P9DFM6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Klotho</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550190.2">
        <property type="nucleotide sequence ID" value="XM_004550133.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFM6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032967"/>
    <dbReference type="Ensembl" id="ENSMZET00005034055.1">
        <property type="protein sequence ID" value="ENSMZEP00005032967.1"/>
        <property type="gene ID" value="ENSMZEG00005024578.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157614"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040016">
        <property type="term" value="P:embryonic cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000042">
        <property type="entry name" value="Klotho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000062">
        <property type="entry name" value="Klotho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF10">
        <property type="entry name" value="KLOTHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017933168" evidence="10">
        <location>
            <begin position="20"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="978" mass="111670" checksum="2F38E0C522BEE95B" modified="2019-02-13" version="1">MKALLTFVTFLGFVTPVTAKPNAGLKTWGRFNKLPYPADKAFLYDTFPKDFIWAVGTAAYQVEGAFEKDGKGLSIWDTFTRGGTRMITGDVGSDSYHNINADIRAIKQLGVSHYRFSLSWSRIFPNGTRGSYNEIGTNYYRTLIKKLKEIRVEPVVTLYHWDLPDHLQQTLGGWSNPELVGIFKDYADFCFQAFGDDVKYWITIDNPFVVARHGYGTGVVAPGIKTDPDLPFRVGHNLLKAHAAAWHLYDRHYRPRHHGKLSMALASHWIKPSRTRLESLRECQCSLDHVLGWFARPLFIDGDYPPCMKSRLGSRLPSFTPEESEQVKGTADFFALSHGAALSFHLINDSLKFGQQEDLDLRMLLYWVNTEYDNPPIFVVQSGWYVLGNTKTKDPKHMYYLKRFIAEALKSIVIDGVNVIGYTAWSLIDGFEWHREYGIRRGLYHVDFNTPDMKREPKTSATFYRNVIQSNGFPELPENRPVQGSFPCDFAWGVSANSIQVETTPTQFADPNVYLWNISNNGELLKLEGFSAPPLHRTPHCADYATIRQQVEEIRQIGVNHFHFSLNWSALVPTGDVAHPNTTLLGYYRCFSRQLLQANVTPVVTLWHHTRQRSSLPAPLDTANKWLNSKTPEAFADYARLCYRELGAYVKIWITLNEPNDEMVSYPEGHEMLRAHALAWHAYDREFRYAQGGKVSLALHMDWVEPAFSFSRKDVEPAKRVLDFCVGWFAEPIFGSGDYPVGMRSWLRQLNSLELPVFKKDDRQLVKGTYDFFAISHFSTKLVTHAKEDSYTYTAMLEVQHMIDTTWIMSPRPVVPWGLRKALNWVKEHYSDVPVYVMANGVQEDPARFKDSLRVYYLYNYINEALKAYTLDGVNLKGYFAYALNDQRDPGFGLYGQVHEEVIVKASLSNYRNIIEHNGFPIQGAEPQLCPSVAPPCHSCHVLGKSPVMGFLILVGSGVLITLGLIIYYTAKRHKECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DH89</accession>
    <name>A0A3P9DH89_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zgc:66448</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560048.1">
        <property type="nucleotide sequence ID" value="XM_004559991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DH89"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034090"/>
    <dbReference type="Ensembl" id="ENSMZET00005035288.1">
        <property type="protein sequence ID" value="ENSMZEP00005034090.1"/>
        <property type="gene ID" value="ENSMZEG00005025481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469763"/>
    <dbReference type="GeneTree" id="ENSGT01030000234576"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002288">
        <property type="entry name" value="Zinc finger protein 700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="739"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="861"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="913"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="828"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="870"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1074"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141950" checksum="8CF83262162012A2" modified="2019-02-13" version="1">MAAADPAKSPKRQKIAEEEVETCGEKTEAVESGCSARQKDENTCNKTGGSPNDEQRADVGSDGGGCVASHSEVTVESGAGADKTTCILPEDLRAAEKMAEASGSDQRPFDWSETEDDGKEAQTHAEENDKCDLNSVCEDAEEVQQDKRVDSDIATNAEEPHVEEKSAVKPQNKDFVGEVDGIEDVVEDDEEADRGVDTDLTAKQKKCRLVCKECGKRFTRRETFNLHRHFHAHEDELTPLTCKECGLTFQHRSSLIKHRNEHRESEEPQLITPKKEVQMMEEGIFQCAECERIFSTVSQLRDHNCSNTVEKPYHCPLCRQDFQFKVSVTKHMMTHSHESAFTCQECSQTFPNTTALRFHQRCHAALKPYECPECGMVFKHYSVMEDHRRKHTDNSRSHLCNICGKTFKYSSLLHQHQYLHTGQKPFRCPECGKKFAFAQNMKAHCRQHRLRETNSCSAQTSKQAPAAEQEEVRGPGKENAHQSEEPKRTFNCPLCPQTYCAPANLRAHMLIHEAEYEKLERSPRLPKDVNKYWDKGHTCPHCPSIYRDESSLNVHLLSVHKSVSQYLERLAAPPKKQFTPLTSDNVQVKWKSESISVKSYKCSECGKTFRHRSVLELHMRIHSKDKPYQCKVCGKGFRFSSYLQQHLIIHTGKKPYKCSDCGKDFAFLQNMRTHQKLHQEKPFRCTSCRKGYSDEIQLQHHMLSHNGDKPHKCDQCDKSFGLAYLLRDHMNTHTGERPHRCEECHKTFSWFSSLLVHQKIHARKRQSFSQYSSFPMSSRMRGRGRRGGRPVWGFSRPLGGSGMTTPQQLSYPVSVVRDAELHRRAVQPPSSMHASRMDLQSRQQKEQWLSELHPQPVQWKVDGGEVMPVPSSQHQHGAPQQTQFDSSVLQQHHRTSSSWADIPLISQSGSTSVQSLDSAHTKDGTSSVAASHLVSVPKKSSPSAVNEMVQHRQHKPVSWSSTPTSTVLASTSSVQHEFSVPSSYIDGAALWSVRPTPLVNSQGSPSKLGQELQLPRWSVIPVSSQKEPSTPPKKEDRVWDLSNPQLIPSTVSQPEKPWNGCEPQKPWASGLAGASTSAQIDQSSAMPISSPVSHGASSTLWDIQTPPGIPKTINSTEKLVNNQDFQLQQKQASSGWANVQTATQKVPISIQYEPHRFGQGMGTPVWGFQNNPVGPQTLLSGQLKPGNGPELQQQPMAVMSERPHMPQTLSLPQLAPRTETHKLGSRLPFAPERLLQCMICGCSLPRELDLQMHYLQHAQGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK65</accession>
    <name>A0A3P9DK65_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the POU transcription factor family. Class-3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DK65"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034779"/>
    <dbReference type="Ensembl" id="ENSMZET00005036017.1">
        <property type="protein sequence ID" value="ENSMZEP00005034779.1"/>
        <property type="gene ID" value="ENSMZEG00005026000.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160115"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000972">
        <property type="entry name" value="TF_octamer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF46">
        <property type="entry name" value="POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00029">
        <property type="entry name" value="OCTAMER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="14">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="379"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="381"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="481" mass="51446" checksum="AC6106019A6EA8E8" modified="2019-02-13" version="1">MKTSPFSLSPTPVGNKGKIEDGAEITHSTALPAPPSQQQQQAQHHHTQLMLAGSQLAGLAALLPAQQQLLLQQAQAQLLAAAVQQSNAAHAAHAAHAAAQQQANQQQQQNQSQSQQQQQQQTKQEQTVQAPPPPPQLALSQPIQLTAQDIQQLLQLQQLVLMPGHPLQSPAQFLLSQPAPAQQSQQGLLSTPNLIQLPQQSPGGLLTSPPRLGLQAQREKSSDAGSSSSGGSLVATGSSGVGVVTSVGVTSASSSAMASSLASGLSSGGHGGHGGHMGEEPSDLEELEQFARTFKQRRIKLGFTQGDVGVAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLSDAETMAVDSMLPSPSSISSPMLGIEGLPGRRRKKRTSIETNVRIMLERNFSTNQKPTSEEILLMAEQLNMEKEVIRVWFCNRRQKEKRINPSSSTTPPLPSQTSPVVTHKAPCYSPHMVQSALYAGTDVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DL74</accession>
    <name>A0A3P9DL74_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor A domain-containing protein 5A-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DL74"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034942"/>
    <dbReference type="Ensembl" id="ENSMZET00005036187.1">
        <property type="protein sequence ID" value="ENSMZEP00005034942.1"/>
        <property type="gene ID" value="ENSMZEG00005026137.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162662"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="650" mass="70631" checksum="80C3A69C52B1F20A" modified="2019-02-13" version="1">MDCCGLLTLQKEPVPLKSIEVELEVRDHVATVVSTLNYENKEDKPLEAVFVFPLPGDAAVCHFSAQIGQTQIVAEVKEKQKAREEYDDALSSGQQAFLLEESDESPDIFSLRVGSLPPAESASIRLEYVTELAVQADDGLRFCLPGVLNPRYQPQGSEGAGVQVTSVPASLVPYSLSFSARVSSPRPVSKVESNCSLDPLQYLNTDQTQATVKLAAGHKFDRDVELLIYYKDAHQPTAVVEAGQASAEPGSLMGDPVVMVSLYPEFPQSVMSSKASCGEFVFLVDRSGSMDCATNNTEQQETRISSAKDTLLLLLKSLPMGCYFNIYSFGSSYEHIFPKSVEYGEKTMEEALKKVEQMEADLGGTEILEPSNILQPALHPTQPRQVENTKEVIDLVKKNSGSHRCFSFGIGEGASSALINGMAKEGGGHAQFITGTDRMQPKVMQSLRFALQPAVEDVSVTWDLPKGSTVTVLSPPITAIFQGKRSLIYAQLTGQAAEGCVMVKYSLAGHPSENQLHFSLRPAEDTGLIVHRLAARTLICLLEMEAENNEEKEEVKKKVVQLSVQSGVSSSFTAFIAVNKDNNKEIQGPLLHRDIPMAGLMGFAATHCCLTANISSFSPGEYKVCYLCKHSVSTSTITGVCLCLCVCEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DN38</accession>
    <name>A0A3P9DN38_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Lysine-specific demethylase 2B</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">F-box and leucine-rich repeat protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">F-box/LRR-repeat protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">JmjC domain-containing histone demethylation protein 1B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">[Histone-H3]-lysine-36 demethylase 1B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_014264852.1">
        <property type="nucleotide sequence ID" value="XM_014409366.1"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005035617"/>
    <dbReference type="Ensembl" id="ENSMZET00005036877.1">
        <property type="protein sequence ID" value="ENSMZEP00005035617.1"/>
        <property type="gene ID" value="ENSMZEG00005026610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465495"/>
    <dbReference type="KEGG" id="mze:101465495"/>
    <dbReference type="CTD" id="100536129"/>
    <dbReference type="GeneTree" id="ENSGT00940000154717"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048701">
        <property type="term" value="P:embryonic cranial skeleton morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21785">
        <property type="entry name" value="CTD_KDM2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22180">
        <property type="entry name" value="F-box_FBXL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15644">
        <property type="entry name" value="PHD_KDM2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000005">
        <property type="entry name" value="lysine-specific demethylase 2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000020">
        <property type="entry name" value="lysine-specific demethylase 2B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000011">
        <property type="entry name" value="Lysine-specific demethylase 2B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
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        <property type="entry name" value="DUF7885"/>
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        <property type="entry name" value="PHD_4"/>
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        <property type="entry name" value="zf-CXXC"/>
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        <property type="entry name" value="JmjC"/>
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        <property type="entry name" value="LRR_CC"/>
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    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="19" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="20" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 31" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="35">
        <location>
            <begin position="151"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="34">
        <location>
            <begin position="557"/>
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        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="33">
        <location>
            <begin position="610"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="363"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="524"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="676"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="741"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
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            <begin position="443"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="32">
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            <begin position="524"/>
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            <begin position="537"/>
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            <begin position="1023"/>
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            <dbReference type="ARBA" id="ARBA00001954"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
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    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
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    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1393" mass="158905" checksum="60B1DEA5E30C4350" modified="2019-02-13" version="1">MAQAAETCAESGRRLRSISRTMYDENEDLSDVEEIVNIRGFSVEEKVLSDSYSADFVRVMEGKDFTYEYVQREGLRIPLIFKEKDQLGIRMPDPEFTVSEIKGLVGSRRSVDVMDVSTQKGSEMSMAQFVRYYETPEEERDKLFNVISLEFSHTKLENLIKRPTVVDQVDWVDNMWPPGLKQSQTEATNIISEMKYPKVQRYCLMSVKGCYTDFHIDFGGTSVWYHVFKGQKVFWLVPPTPYNLALYEDWVLSGKQSDVFLGDRADGCQRVELQQGYTFFIPSGWIHAVYTPVDTLVFGGNILHSFNIPMQLTIYEIENRTKVHSKFRFPFYYEICWYVLERYLHCLTKRSYFSQEIRKESMDFETKSKTESPSSDSRSQDMNEDSCGTHVRDEQGEKLERVPQDGPCTPDNGKGQHLKAVLSIDSEDSCNPSSASLDFLKTPSDSPNSEPQNKWIHLTEFELNGLRTLIEKLESLPENRKCIPMGIENPQALLDDLKVVLKEHTDDDPKLAITGYPVVYWPKKTIKPRPPNRPKPKMAASPASAVKLSASRGTSGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEDEEEKFNLMLMECSICNEIVHPNCLKIKDSNGVVNDELPNCWECPKCNHAGKTGKASKQKRGPGFKYASNLPGSLLKEPRLNRDSKEEPDLPMVAPTPIAALTTTSAVKRKVERDVIAKKNDEEPPKKRPPLLSLDGMPRPRLEDNPLRKKRKLFDTNDEPSFVKKKKKLSKPDDSFTSKLLQHIKRENDHGDEEDDQEDHEEDGLSLERMHLREKNEYDDEDQDGDAEEEVMVKKERDNNAEDKAKVLLSPLLRTSAARESDQTSSNSPRAGPSGESGEAQERSSAQLKARHQRKRLPNKEASKEFCQETPKIEDCLSSQKLGSVKKEEDSPANLNRRPLKTEDSLTNQNRKPLKTEDPPANPSRKALKMEEGVNNQNRLPLKTEDSLTNQNQRPVKSEPESEVDEQKPRWPLNNGSSDLGDWLRHRGREMNGMPRGYSPLSWNRNTPIAPICPRPLPCRSPPKCIQMERHVIRPPPISPPPDRLPLNDGEAHVMQRETWMMVFGHLSHRDLCVCMRVCRTWNRWCCDKRLWKHINLNRCKSITPLMLSGIIRRQPVALDLSWTNISKKQLSWLINRLPGLRVLLLSGCSWVAVSALCTSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQLDNRSKLRNVEDLRLAGLDITDTSLRLIIRYMPLLSKLDLSYCNHVTDQSVNILTAAGTTTRDSLTDINLSVCNRVTDQSLTYFKRCGSICHIDLRYCKQVTKEGCDQFIAEMSVSVQFELIEDKLLQKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRF6</accession>
    <name>A0A3P9DRF6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger, CCHC domain containing 24</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004551684.1">
        <property type="nucleotide sequence ID" value="XM_004551627.4"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005037034"/>
    <dbReference type="Ensembl" id="ENSMZET00005038326.1">
        <property type="protein sequence ID" value="ENSMZEP00005037034.1"/>
        <property type="gene ID" value="ENSMZEG00005027600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479239"/>
    <dbReference type="KEGG" id="mze:101479239"/>
    <dbReference type="CTD" id="219654"/>
    <dbReference type="GeneTree" id="ENSGT00390000008264"/>
    <dbReference type="OrthoDB" id="10038672at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057809">
        <property type="entry name" value="ZCCHC24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23490">
        <property type="entry name" value="ZCCHC24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="239" mass="27175" checksum="92C8EB6A110B5BB5" modified="2019-02-13" version="1">MSLLSAIDTSASVYQPAQLLNWVYLSLQDPHQTSAFDAFRPEPNSSHPDLSFSKTPAAADLSSSLNSNYLNNFFQLQRNEALNNNVYKNVSPYGSLNNIVDGLNSLTDHFSDLSLSSETRKPNKRPPPNYLCHLCFNKGHYIKDCPQARPKGEGLTPYQGKKRCFGEYKCPKCKRKWMSGNSWANMGQECIKCHINVYPHKQRPLEKPDGLDVSDQSKEHPQHLCEKCKVLGYYCRRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRQ4</accession>
    <name>A0A3P9DRQ4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Si:ch73-290k24.6</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004574929.2">
        <property type="nucleotide sequence ID" value="XM_004574872.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRQ4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037445"/>
    <dbReference type="Ensembl" id="ENSMZET00005038751.1">
        <property type="protein sequence ID" value="ENSMZEP00005037445.1"/>
        <property type="gene ID" value="ENSMZEG00005027922.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101475941"/>
    <dbReference type="GeneTree" id="ENSGT00950000183109"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021684">
        <property type="entry name" value="WBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051994">
        <property type="entry name" value="WW_domain-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209:SF5">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11669">
        <property type="entry name" value="WBP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="843" mass="89223" checksum="969E50AE014DBCD3" modified="2019-02-13" version="1">MEYHSGGSQPLLGRPRYCPGASVNGGYLCETGHCCGETGCCTYYYELWWFWLLWTVLILFSCCCAYRHRRAKLRVQQQQRQREISLLAYHGANSYPSSMLDLSFLASLKLPSYEEVAAQPSTPPPPYSSVFTTPRYPQPPRTADPHLLTQHGPLLHRPHSDGPSSLSSDNSSSCSCDSCCPSSPCSSSLSAPITYETDTSHASTPSEATPLTLDVTMETISAAATYLNSKETQVASERMVLDVADVSGAGAHTAVATNSSVSNQTVTVAVVTRAASPQPPPSPGFQLTLPVGTTSPIKQQLDIAPCTPIVSTCSSSTLPSPNVVDTALPSIQIIQSPAMDTNTVQNDTPKIPLMSRLPTPTASDSSITIKSLETLNLTRTFDTVSSPNSPASVPSPDAGRTLSPIASSVSGCLTPDPTLVPIPSPTKLTQSPVQEHTKFTQGQEPQSLFLKLTQPPDLVTSDHILLPNPQPKAGVVADSPVNSLLSPRHANLALVTDAAPTLPILTQCQNLELSPGSGLVEGHPSPGSHLSQHLGSIAVSTSCLDSTAETDHSGHSLVPPRLSEFDHIPPLPSNAQACFSSGSCSGFELRPGAGSESEPLSTPTPLLTFSEQVSTASPCPAITIESESSYATCQSPLATLSPSSPPSLSTSPPPPLTLQALSSTSLPAPALLLDPLTAFHQSDKGGSSSGHASSLSPSPRATQSPPKQTLFSPCVDVFEPGPPSWENEDEDQEEKDNDEDDDEDMGADESQYRHRRLTGDSGIEVCRCRVEEEDEEEEEEGGRRGNGGERDKRNSDSDLHDSVDCPARGQVTTEEGLTLCTPTATTTPTSEDSGEVVIVMETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS23</accession>
    <name>A0A3P9DS23_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adducin 3 (gamma) b</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551601.1">
        <property type="nucleotide sequence ID" value="XM_004551544.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004551602.1">
        <property type="nucleotide sequence ID" value="XM_004551545.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS23"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036921"/>
    <dbReference type="Ensembl" id="ENSMZET00005038211.1">
        <property type="protein sequence ID" value="ENSMZEP00005036921.1"/>
        <property type="gene ID" value="ENSMZEG00005027515.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005038214.1">
        <property type="protein sequence ID" value="ENSMZEP00005036924.1"/>
        <property type="gene ID" value="ENSMZEG00005027515.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484045"/>
    <dbReference type="KEGG" id="mze:101484045"/>
    <dbReference type="CTD" id="553243"/>
    <dbReference type="GeneTree" id="ENSGT00940000155257"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000004">
        <property type="entry name" value="gamma-adducin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF5">
        <property type="entry name" value="GAMMA-ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="12">
        <location>
            <begin position="143"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="632"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="694" mass="77183" checksum="664EFF60AE9EAA70" modified="2019-02-13" version="1">MSLVDVRQTVGSLTLALSSNDSKERYFDRVDESDPEYLRSKNMSPDLRQDFNMMEQKKRVTQILQSPVFKDELEGLIQDQLTKGNNPTGLMALRQIADLVMASTTGGAGPLTAPISIGMVTPVNDLYGVESPSFAKGEKQSRCKLASLYRLVDLFSWARFTSSYITVRVSKEQDHILISPRGLSFAEVTAANLVKVNIIGEVVDQGSTDLGIDQFGFAPHSAIYSMRPDVRCIIHAHTAVTAAVSSMKCGILPISQEALLLGDVRCFGYHGSLDDKETKVEFQKALGPTAKLMILRNHGLLALGETVEEAFHYMYHSQLACEIQVNAMRCSGGADNLVLLDRDKFKPLTQGVAAAGVVIDNEVKWKIGEAEFESLMRMLDNLGYRTGHSYRNPIVREKPRSKNDVEIPATVSAMPPEDCELGLRSPFKFMAQKQQRERTRWLNSPNSYLKVNVPEQSPSGDVSPRTKTMWMKSSQPGYSVGTPIKIEDPNQFVPLNTDPTEVLDKRNRIKEQHRGDQMTPGPKSQLLAGIVVDTIPGPAFIIEDEEQTRSLPPNPFNDLTEKALEEYKSMVERKQQGQEEDDDATDADEMTTFDGSTISLSLSPIMTPAKQDTIPNGKDHLAEMEEDLSIEVSKLSVSTSETVEISITTKEKTGEPQTPESQTKSPKKKKKKFRTPSFLKKSKKKKEEKEKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AS63</accession>
    <name>A0A3P9AS63_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 20">Protein kinase C</fullName>
            <ecNumber evidence="4 20">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="4 20"/>
    <dbReference type="RefSeq" id="XP_012779789.1">
        <property type="nucleotide sequence ID" value="XM_012924335.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024661503.1">
        <property type="nucleotide sequence ID" value="XM_024805735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AS63"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000237"/>
    <dbReference type="Ensembl" id="ENSMZET00005000293.1">
        <property type="protein sequence ID" value="ENSMZEP00005000237.1"/>
        <property type="gene ID" value="ENSMZEG00005000194.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466316"/>
    <dbReference type="KEGG" id="mze:101466316"/>
    <dbReference type="CTD" id="5588"/>
    <dbReference type="GeneTree" id="ENSGT00940000157638"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20834">
        <property type="entry name" value="C1_nPKC_theta-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20837">
        <property type="entry name" value="C1_nPKC_theta-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000360">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000003">
        <property type="entry name" value="Protein kinase C delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000049">
        <property type="entry name" value="Protein kinase C delta type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000008">
        <property type="entry name" value="Protein kinase C theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000150">
        <property type="entry name" value="Protein kinase C, theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014376">
        <property type="entry name" value="Prot_kin_PKC_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21494">
        <property type="entry name" value="PKC_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000551">
        <property type="entry name" value="PKC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="25">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="25">
        <location>
            <begin position="237"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="393"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="26">
        <location>
            <begin position="648"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="399"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22 23">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="720" mass="82006" checksum="92D16A9403C83B5A" modified="2019-02-13" version="1">MSPFLRIGFSHFEIDPGLAYHEEVLNPYCAVYMKEAVDTEKGQVYKQKKPTMYPPWSTTFDAHVHRGRIMHVMVKDRTAELKSEATVALDSLATRCKKENGKLEIWLELKPQGRMLMEARYYLEKSDAVGHTDGDPESEREREGLFTLHQRRGAIKQAKVHVVKCHEFSATFFPQPTFCSVCKEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSKETMIHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLAKQGLKCEECSMNVHHKCQKKVANLCGVNQKLMAEALAVIESKQQARSTRDSDIIGREGPVSVAQPGVVRAPSGLVMGLPATATPASKADYQGVSWEGPGDVSRSVSEVLPEEPLYAVPRKDHQPKFTIDDFTLHKMLGKGSFGKVFLAELKRSGEFFAVKALKKDVVLMDDDVECTMVERRVLSLAWENPFLTHLYCTFQTKENLFFVMEYLNGGDLMFHIQNCHKFDLHRATFYAAEIICGLQFLHSKGIIYRDLKLDNVLLDLDGHIKIADFGMCKENMQDDVRTSTFCGTPDYIAPEILLGQKYNSSVDWWSFGVLLYEMLIGQSPFHGRDEEELFQSIRTDTPIYPNWLSKAAKDILIKLFVREPEERLGTKGNIRHHSFFSSTDWNALEQRQVPAPFTPTITSPSDCSNFDKEFINEKPRLSCADRTLINSVDQTMFRNFSFVNPGMVRIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AT19</accession>
    <name>A0A3P9AT19_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Component of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex composed at least by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGA, PIGC and PIGQ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AT19"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000834"/>
    <dbReference type="Ensembl" id="ENSMZET00005000909.1">
        <property type="protein sequence ID" value="ENSMZEP00005000834.1"/>
        <property type="gene ID" value="ENSMZEG00005000734.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001098"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="73" mass="8447" checksum="07CC2E40DCBEE34A" modified="2019-02-13" version="1">MSLVVFSLVLFTYYSVWVIILPFVDSDHFLHKYFLPREYSVILPGIAAVILLICIGAFTVVIMWKNRKPKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATK3</accession>
    <name>A0A3P9ATK3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Si:dkeyp-97b10.3</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
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        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040261">
        <property type="entry name" value="FAM240"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40387">
        <property type="entry name" value="PROTEIN FAM240B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40387:SF1">
        <property type="entry name" value="PROTEIN FAM240B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="60" mass="7290" checksum="B8221D748289CE84" modified="2019-02-13" version="1">MNLALVHDRELIKTFWERRIETQTQQADSEEQRMSQSALKLRGEWLVRLENRTKHLKNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXD2</accession>
    <name>A0A3P9AXD2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lysosomal acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Lysosome membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
            <orientation evidence="13">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004573332.2">
        <property type="nucleotide sequence ID" value="XM_004573275.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXD2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002299"/>
    <dbReference type="Ensembl" id="ENSMZET00005002400.1">
        <property type="protein sequence ID" value="ENSMZEP00005002299.1"/>
        <property type="gene ID" value="ENSMZEG00005001825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465169"/>
    <dbReference type="KEGG" id="mze:101465169"/>
    <dbReference type="CTD" id="53"/>
    <dbReference type="GeneTree" id="ENSGT00940000158446"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000010">
        <property type="entry name" value="Prostatic acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF180">
        <property type="entry name" value="LYSOSOMAL ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018136117" description="Lysosomal acid phosphatase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="421" mass="47666" checksum="7C35D1DC1D14B7B1" modified="2019-02-13" version="1">MVPAAVLFVFTLTCVCGRAAAERKLVYTTVLFRHGDRSPVKAYPTDPHQESDWPQGFGQLSQIGMQQHFELGQFLRTRYKKFLNASYNRHEILVRSTDYDRTLMSAEANLAGLYPPSGQQVFNPNLKWQPIPVHTVPQSEERLLSFPLKDCPRYQQLMNETEHTEEFLNVTATYQDIIELVRNKTGLKDTTVETVWSVYDTLFCESQHNMTAPDWVSPDVMKKLQKLKDFGFQVIFAVHEQQEKSRLQGGMLLGEIVKNLSKMAVPDPKQQLKMMMLSAHDTTVAALLASLSVFNGIQPPYASCLMIELYREDNGSASVSMFYRNNTKEPPYPLQLPGCSLDCPLDEFVTITKVFISDDRDKECQLPSKHTDKLVITSLAVTGCVLLVLIVILLGVLCRHKDPINSRGYQHVINQEGGEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXZ0</accession>
    <name>A0A3P9AXZ0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfotransferase</fullName>
            <ecNumber evidence="6">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004543335.2">
        <property type="nucleotide sequence ID" value="XM_004543278.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXZ0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002555"/>
    <dbReference type="Ensembl" id="ENSMZET00005002668.1">
        <property type="protein sequence ID" value="ENSMZEP00005002555.1"/>
        <property type="gene ID" value="ENSMZEG00005002012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466775"/>
    <dbReference type="KEGG" id="mze:101466775"/>
    <dbReference type="CTD" id="57429"/>
    <dbReference type="GeneTree" id="ENSGT00940000163403"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="287" mass="33238" checksum="FC0409F906EA7E8D" modified="2019-02-13" version="1">MARLDVTEMFHGISFPGHLHTQDSLKYAVSFPFLDTDILIVSYPKSGTTWLQEVVTLIRTRGNPGLSQTVENWKRAPWLEHYYSSALLEALPTTARVITTHLPHHLLGPALQHSKTKVIYVSRNPKDVVVSFYHFHKMANFLPEPHSFPDFLDRFLDETVSFGSWFDHIKGWTSQINSNLLHITYEEMSLDLHGTIKKISSFLQCPLVEDEVNNCVKHCSFSSMKENKMINYTLVPQQIMDHSKGSFMRKGKVGDWKNMFTEEDSRKFETVFTSKMMENSTLEFVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXZ5</accession>
    <name>A0A3P9AXZ5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myogenic factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2 11">Efficient DNA binding requires dimerization with another bHLH protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXZ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002528"/>
    <dbReference type="Ensembl" id="ENSMZET00005002641.1">
        <property type="protein sequence ID" value="ENSMZEP00005002528.1"/>
        <property type="gene ID" value="ENSMZEG00005002005.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182959"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048743">
        <property type="term" value="P:positive regulation of skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Myogenic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022032">
        <property type="entry name" value="Myf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002546">
        <property type="entry name" value="MyoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039704">
        <property type="entry name" value="Myogenic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534">
        <property type="entry name" value="MYOGENIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534:SF3">
        <property type="entry name" value="MYOGENIC FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01586">
        <property type="entry name" value="Basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12232">
        <property type="entry name" value="Myf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00520">
        <property type="entry name" value="BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="299" mass="32565" checksum="557E1AFFD1472A24" modified="2019-02-13" version="1">MVIRSGQCGPWALASGHIRGAWGNRPLISLRGLFSFTQTLLPFFLTSFAAISFSIQQAMDVFSPSQVYYDRACASSPDSLDFGPGMELAGSEEDEHVRVPGAPHQPGHCLQWACKACKRKSSFVDRRRAATMRERRRLKKVNHAFEALRRCTSANPSQRLPKVEILRNAIQYIESLQELLREQVENFYGLPGESSSEPGSPLSSCSDGMADSNSPVWQQLNANYSNGYSYAKNNSVDDKAAGASSLECLSSIVDRLSSVESSSCGPAGLRNTSSFSPGSSDSQPCTPESPGSRPVYHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYY2</accession>
    <name>A0A3P9AYY2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Growth arrest specific 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004575167.1">
        <property type="nucleotide sequence ID" value="XM_004575110.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYY2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002814"/>
    <dbReference type="Ensembl" id="ENSMZET00005002931.1">
        <property type="protein sequence ID" value="ENSMZEP00005002814.1"/>
        <property type="gene ID" value="ENSMZEG00005002177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466334"/>
    <dbReference type="CTD" id="557312"/>
    <dbReference type="GeneTree" id="ENSGT00940000155755"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.20:FF:000003">
        <property type="entry name" value="Growth arrest-specific 2 like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF9">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="223"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="336" mass="37473" checksum="104B59974F1D544D" modified="2019-02-13" version="1">MCSSLSPKQPSGPGLTDMQQYQQWLSSRHEASLLPMKEDLALWLTNILGLEITAESFMDRLDNGFLLCQLAETLQEKFRQSNGDLPTLGNSKRIPNRRIPCRRSAPSGSFFARDNTANFLAWCREVGVGETCLFESEGLVLHKQPREVCLCLLELGRIASRYNVEPPGLIKLEKEIEQEEKAPLPPPSPVSPAQPVPPSPSSSPSPSPSPSPTPTKVTSIKKSTGKLLDDAVRHIANDPPCRCANKFCVERQSQGRYRVGEKMLFIRMLHNKHVMVRVGGGWETFESYLLKHDPCRMLQISRVEGKISPISSKSPNIKDLSPDSYLVVAAHYRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0A2</accession>
    <name>A0A3P9B0A2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Syntaxin binding protein 5L</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0A2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003331"/>
    <dbReference type="Ensembl" id="ENSMZET00005003463.1">
        <property type="protein sequence ID" value="ENSMZEP00005003331.1"/>
        <property type="gene ID" value="ENSMZEG00005002546.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182906"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000521">
        <property type="entry name" value="syntaxin-binding protein 5-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF19">
        <property type="entry name" value="SYNTAXIN-BINDING PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="7">
        <location>
            <begin position="282"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="988" mass="109829" checksum="B89465B11F36F6AD" modified="2019-02-13" version="1">MKKFRKVLDGLTTSSPGATVGSPSCGSAAGTPTAAPTPKEIDVQETLVSENFQLCKTVRHGFPYQPTALAFDPVQKILAIGSRSGGVRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSACADDTLHLWNLRQRRPAILHSLKFNRERITFCHLPFQSKWLYVGTERGNTHIVNIESFVLSGYVIMWNKAIELSTKTHPGPVVHLSDSPKDEGKLLIGFESGTIVQWDLRGKKADFRIYYDEAIHSVSWHHEGKQFMCSHSDGSLTLWNLRNTTKPFQVTFPHGKIQKDARKESCKPILKVEYKTCRNSEPFVIFSGGLSYDKAGRRPALTIMHGKAITVLEMDYPIVEFMVLCETPYNNEVQEPYAVVVLLEKDLIVVDLTQSNYPVFENPYPMDIHESPVTCTAYFADCPPDIIPILYSIGAKHKKTGYSQKEWPISGGTWTLVRNADRNTDDPSLTPPMLYKMKTSKVFEKPKPGEGRAAELVEEDPFAIQMVSWCPQSRMFCVVGISAHIILYRFSKYDANTQIVSLEVRLQCDSDDVISPSENENNPSFSEPGSHSPQPHHQHQHPASPGSRTPEGIKDSIPCLKVKDRAVRVPPGYQSELVIQLLWVDGEPPQQITSLDINSAYGLLAFGNCYGLAVVDYLQKTVILCMSTLDLYGSTDPYQRLTRSPRRNRQSTSGLTELTDNQQSIDMERNKSPTSDHVNGHCTSPTSQPCSAGKPRIPMGPEGPRLTRRGPGRPPFRKAQSAACMEISLPVSHTEESRENSFTRSRSSSVSSIDRDTKEAVTTLQFGESYGRKNDVLPTPCLWVGTSLGVVLLIPMSIPTDQEERMEEPVTMGVSGAVLMLKGSVLRFSFLDCMGALIQPPYEVWRDHNAPEDPDRLRRRKLVHFSPSSSQDACGDGHLAVVCSERQAKVFLMPSQSCLFVHNITESSFVLRADVVSVCNSVCLACFCANGHVMTLRYDHGRSSSLLLDVCFNLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B164</accession>
    <name>A0A3P9B164_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Methionine sulfoxide reductase B1</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:21260"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58773"/>
            <dbReference type="EC" id="1.8.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B164"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003457"/>
    <dbReference type="Ensembl" id="ENSMZET00005003589.1">
        <property type="protein sequence ID" value="ENSMZEP00005003457.1"/>
        <property type="gene ID" value="ENSMZEG00005002678.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005035479.1">
        <property type="protein sequence ID" value="ENSMZEP00005034275.1"/>
        <property type="gene ID" value="ENSMZEG00005025618.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047678"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052150">
        <property type="entry name" value="MsrB_Met_sulfoxide_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46755">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46755:SF5">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="17">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="92" mass="10275" checksum="4A32A0514C9DA249" modified="2019-02-13" version="1">MSHCSFSGGEEYKNHFQPGIYVCSECGHELFSSMSKFEHSSPWPAFSQTIREDSVSKHPEAWGPIKVCCGKCGNGLGHEFLYDGPREGLSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1E4</accession>
    <name>A0A3P9B1E4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Grid2 interacting protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005003755"/>
    <dbReference type="Ensembl" id="ENSMZET00005003908.1">
        <property type="protein sequence ID" value="ENSMZEP00005003755.1"/>
        <property type="gene ID" value="ENSMZEG00005002859.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157625"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
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        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF13">
        <property type="entry name" value="DELPHILIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="671"/>
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    <sequence length="1397" mass="159240" checksum="01721668879EF009" modified="2019-02-13" version="1">MRVTGTTYRSSVRGRSSDDLVIGTHLGMGHRAEPLLETGMRLAPGERQSGDGTSLPETPNNLTNLSAVYAELENMYSAKRSKSLKSRPPPAPESLLDLDPPSRTASPTIHLNTGSRKGPSSHTSWPEPLPSPPQSQFYPSGLTSQTSGESNPYISLDSPPPSPPEPPDYPSSPPAHRSSKRRYTFSKPPRSEDTDRFLDALSEQLGQRVAIVDDFLTPENDYEEDVVQMGFPDEEDDDNEDDLVVDEEESGGFVAPELSSPSDVQSSSGEENASSLTYSSSSDHIPPPPMTPPPPPPVQFNDPPPPPPPPAPAQSQPQHQQQQQQQQLSYTPEHSPRTYVPIRRKSGPPPPPPPRSNPPPKRHSLHKVLPTREDLQVHATIQELKAYQEQQAYQERQAYEEQQAYKERQAYEEQKAFEEQQLLQEQQALQEQQAYQEKLFKERQAYEEQKAFEEQKAFEEQQLYQEQQAYQERQAYEQRQAYQEQKAYEQRQAYKEQKAFEELQAYKEQKAFEELQAYQEQKAYEEQKAYEERQAYKEQQAYQEQQLQQIYQSHHSMPAQPTQQKAHSPLPLQSLPPLPSPDSVHHHANHPLYMMRQAQQQQAHQTHHHRRLSRSAPPPHQPSPQPTGHPSQQGQYVEGIYQSHQSVRPQPHHSSTEMLHQMHQAPAHHSSAEVLHQLQQSQAHHSSAEMLQQMQQVHAHYSSSEVLHQMHKSKAHHSSTELLHQAQQMQQIQPLHSSTELLHQAHQMHRGQPHHSSTELLHQIHKPQAHHSSTELLHQAHQMHQPKPHHSSTELLHQTQQEPASLPVQLNRDGHSHQSRRSLKGHHQTEVSVQGRHQEQQIHQTHHPQPTKPSPQRPHSIQQTHHHSSTPQIHHIHHMTPQPPPQDYQHQIQVIHPPQQPHRPQPLLSTFQPLQPHQPTLSTFQPLPQHPQSSTQTARPQSQPSHHLLQSQHQSQSHSQSQPQSLPHSLSDPTEHLEPPPPPPLPPPCSPPPLPRPSLSRMDSNHMSVKRLRWEQVENSEGTIWGQLGANSDYEKLHDMVKYLDLELHFGTQKSAMPAPEPSPQLETFKKKDVIEILSRKKAYNASILIAHLKLSPGELRQILMNMATDRLEPAHIKQLLLYAPDAEEVKKYEEYRQDPSKLSEPDQFVLQMLSVPEYQTRLQCLLFKCSLQEKTEELKGAYDCIYNASMELKTSKKLAKILEFVLAMGNYLNNSQPKTNKTTGFKINFLTELSTTKTVDGKSTFLHILVKSLCQHFPDVLDFSKDLTMVPLAAKVNQRNITSDLNDLHTTIQDIRSACQKMPATSDDRFAVVMSNFLENSHPAIQSLESLQQRAMEEFSKTASYFGEDGKATNTEAFFGIFAEFINKFERALSDQQVAEIPKSPRSPRMASPLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2G2</accession>
    <name>A0A3P9B2G2_9CICH</name>
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        <submittedName>
            <fullName evidence="8">Sperm associated antigen 1a</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
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                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="392" mass="43080" checksum="32FC8946143967A3" modified="2019-02-13" version="1">MGNAQEKPPGGGGGAASADQATAGSGTRSGGGSSGGKPHMAPQKGAVNGTQRENSPAGGQEKKEDSPAVDTSYLDAPAGALPPHLARLKNEGNHLFKHGQFGDALEKYTQAIEGCAEAGIDSPEDLCILYSNRAACYLKEGNSTDCIQDCNKALELQPYSLKPLLRRAMAYESLERYRKAYVDYKTVLQLDTGIQAAHDSIHRLTKMLIEQDGPEWRQKLPEIPVVPLSVQLQHREKPISIEQAQARAARAAQEEARRKEAHFTLLKQEGNSLVKKGHFQEALEKYSECLAIKPDECALHTNRAICLLKLNRFEEARQDCDSALQLEPNNKKAFYRRALAFKGLQDYLSASSDLQEVLRLDPNVREAEQELEVVTGLLRQSLMDNTVHTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5A2</accession>
    <name>A0A3P9B5A2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol transfer protein alpha isoform</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 &gt; C16:0 &gt; C18:1 &gt; C18:0 &gt; C20:4 and for PI is C16:1 &gt; C16:0 &gt; C18:1 &gt; C18:0 &gt; C20:4 &gt; C20:3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38572"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5A2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005081"/>
    <dbReference type="Ensembl" id="ENSMZET00005005305.1">
        <property type="protein sequence ID" value="ENSMZEP00005005081.1"/>
        <property type="gene ID" value="ENSMZEG00005003926.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157119"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008525">
        <property type="term" value="F:phosphatidylcholine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043009">
        <property type="term" value="P:chordate embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08888">
        <property type="entry name" value="SRPBCC_PITPNA-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000004">
        <property type="entry name" value="Phosphatidylinositol transfer protein alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001666">
        <property type="entry name" value="PI_transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055261">
        <property type="entry name" value="PI_transfer_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10658:SF28">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN ALPHA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02121">
        <property type="entry name" value="IP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00391">
        <property type="entry name" value="PITRANSFER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphatidylinositol transfer protein N-terminal" evidence="15">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="279" mass="32487" checksum="7FED2435F896D678" modified="2019-02-13" version="1">MCSFSYSRVVLPVSVEEYQVGQLYTVAEASKNETGGGDGVEVLKNEPYEKDGEKGQYTHKIYHLQTKVSGFIAKIAPKGSLTVHEKAWNAYPYCRTINLIVSHSFLQNEYMKDNFMIKIETWHKPDMGDQENVHGLDPDTWKDVEVVYIDIADKRQIDSKDYKEDEDPAKVRSEKTGRGPLGPDWKKELPNKSDCPHMCAYKLVTVNFKWFGLQNKVENFIQKQEKRLFTKFHRQVFCWLDKWIDLTMDDIRRMEEETQKELDEMRVKDPVKGSTAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5H1</accession>
    <name>A0A3P9B5H1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5H1"/>
    <dbReference type="Ensembl" id="ENSMZET00005005368.1">
        <property type="protein sequence ID" value="ENSMZEP00005005143.1"/>
        <property type="gene ID" value="ENSMZEG00005003986.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234557"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051287">
        <property type="entry name" value="TCR_variable_region"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367:SF18">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="32"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="153" mass="17128" checksum="044123B74E1FC6CF" modified="2019-02-13" version="1">MRAGTRLLHKDLKTKCGPADGSESLRCRVSHPTARTRSGLKADRGTVTLHCLYNTSSLSGTYLYWYKQDGNNSPKFILSRVSGDQGNTADEFKERFSSTLDSSIRSAPLKIQKLQLSDSAVYYCALQPTVTGNSKTLYKNLWSKDNRILHNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6V5</accession>
    <name>A0A3P9B6V5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized LOC101472354</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004556568.2">
        <property type="nucleotide sequence ID" value="XM_004556511.2"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005005537"/>
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        <property type="protein sequence ID" value="ENSMZEP00005005537.1"/>
        <property type="gene ID" value="ENSMZEG00005004294.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101472354"/>
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        <property type="component" value="LG4"/>
    </dbReference>
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        <property type="term" value="C:kinetochore"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zwint-1"/>
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        <property type="entry name" value="ZW10 INTERACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31504">
        <property type="entry name" value="ZW10 INTERACTOR ZWINT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="360" mass="41030" checksum="D094D7778479F79F" modified="2019-02-13" version="1">MAAVRAVLRRCDPALLEPRGEPEPDCDQAARMVLFLTDRRRMQKVLWRQLFVLDSMMSLLEGLESAQQLMAQSCPPQPEGGARGRWKALKVESRSGVEETEALLRSLQDRIQQIHDRRHTLTQLVQHLHSKRQQSEQLESSLLNAQNALQSCDLQLTQLRAESEVMLGHLIEWQRLRDELQVYVSTTQDVMQINLLAFNQSELCVELRPHTSSDLLSNELEPLRLSVTWSHDDRFRLQVSEGTAGLAEDSLTGRRVELSAALLEVMRCYVGQAELLSEIQSLRSSFAIDWHPAQRLLVYLKTASLVCHLEVEEGYPRVGRARLLSVRRDGQHVDTSGLKPPSGELRLTEWLVFLYSSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B707</accession>
    <name>A0A3P9B707_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide Y receptor Y4-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NPY4R2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B707"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005683"/>
    <dbReference type="Ensembl" id="ENSMZET00005005933.1">
        <property type="protein sequence ID" value="ENSMZEP00005005683.1"/>
        <property type="gene ID" value="ENSMZEG00005004403.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161927"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF25">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR TYPE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="58"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="363" mass="41649" checksum="B3E86B7DE9A595F0" modified="2025-10-08" version="2">MPSFLFHLFSLRWRALFETQLLSDFAILEHDEQCHMSPVLTACLVAWYSVTMVLGLVGNIGLICIIARRREKVNVTSIFICNLSFSDILVCVFCLPFTVIYTIMDHWVFGSLLCRLVPFIQCVSVSVSVLSLVFIALERHQLIINPSGWKPSVPQAYMAIVLIWILACFTSLPFLAFQLLTNEPYTNVILPVSSGHRVAYTTWLLLFQYCGPLFLVLLCYVRVIVRLRHRKEMLDRARTPECQRMTHSRRINIMLVALITVFALCWLPLTIFNVVSDWNQEALPVCYHNLLFSLCHLLAMSSTCINPVIYGFLNSNFRQEVSEVLLHCRCFPLEEECEQYPMSTVHIEVSHTSVPLTCRSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8P5</accession>
    <name>A0A3P9B8P5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcriptional repressor scratch 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Scratch homolog 1 zinc finger protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559874.1">
        <property type="nucleotide sequence ID" value="XM_004559817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8P5"/>
    <dbReference type="Ensembl" id="ENSMZET00005006568.1">
        <property type="protein sequence ID" value="ENSMZEP00005006279.1"/>
        <property type="gene ID" value="ENSMZEG00005004875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474327"/>
    <dbReference type="KEGG" id="mze:101474327"/>
    <dbReference type="GeneTree" id="ENSGT00940000154491"/>
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        <property type="component" value="LG5"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="transcriptional repressor scratch 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF60">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR SCRATCH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="75"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="327" mass="36626" checksum="BACE99A54C3AC395" modified="2019-02-13" version="1">MPRSFLVKLPKIHDFSSSNHYYHHQHQQQEQHWDDSYTVTHAITESSTNLAVHLSENRYIQDYIIPSVFKRTKESSHEQTGLTAGPLYSPGGSSGEEFSDHDMEDPDSPVSSTTVESDGSSPETEACTISGFLISDGRSRRRPKQRCSHMEGSHLDSSEGSSSTDCSPAKGESKGRHVCSECGKSYATSSNLSRHKQTHRSLDSQQARKCPTCHKVYVSMPALAMHMLTHDMKHECKVCGKAFSRPWLLQGHMRSHTGEKPFACAHCGKAFADRSNLRAHMQTHSAFKHYSCKRCRKSFALKSYLNKHYESACFKGQSTEGDCSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9Z7</accession>
    <name>A0A3P9B9Z7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Zgc:110269</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570584.1">
        <property type="nucleotide sequence ID" value="XM_004570527.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9Z7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006616"/>
    <dbReference type="Ensembl" id="ENSMZET00005006914.1">
        <property type="protein sequence ID" value="ENSMZEP00005006616.1"/>
        <property type="gene ID" value="ENSMZEG00005005102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485698"/>
    <dbReference type="KEGG" id="mze:101485698"/>
    <dbReference type="GeneTree" id="ENSGT00940000155807"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF49">
        <property type="entry name" value="FLAP ENDONUCLEASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="348" mass="39391" checksum="422A7ED1E0F00700" modified="2019-02-13" version="1">MGITKLADLIRSDAPDAISYKDISDYTGKVIALDTSIVVNQFRAATPTLSPLTGLFFRTLTFLEHGIKPVFVFDGKPPGEKKAVLEKRAQTAGRNYSNWTGTASLQTKECLQLLKYLGVPVIQAPGDAEALCAQLVREGTVHAVASEDMDTLPFGANILIRQLNAKKDSKVIEYSLPKLLEKLQIGHKEFVDLCILLGCDYCEKIPGLGPKRALTLIQKHHTIEDVVLHINRKTHPVPNMWKYREARKIFLDGPQSSAPELIWTEPNEEALVEFLCHTKRIKEERIRNRMVKFRMMRENKREEREKEKAEGGGKQTCIKDFFRVTRKRVQPVDNASSPTSNRKRPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBL9</accession>
    <name>A0A3P9BBL9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBL9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007293"/>
    <dbReference type="Ensembl" id="ENSMZET00005007603.1">
        <property type="protein sequence ID" value="ENSMZEP00005007293.1"/>
        <property type="gene ID" value="ENSMZEG00005005600.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182968"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF127">
        <property type="entry name" value="NITR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018276536" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="43"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="149"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="356" mass="39891" checksum="C23EE40D20E3D5FB" modified="2019-02-13" version="1">MMPLKFALCLTCLGLGSVGKLSLLNTLSSNVRQESGFISANVGDNVTLRCFYEGDVAAMFYWYKQTLGQKPKLISSFYKHDKNGTFSEDFKNNPRFSLDSKNGKNHLTIWNLQMSDSATYYCISCYAYKFEFAEGTTIHVKGSDLNLQTSVHQLSSATVQLGASLTLNCTVHTGTCDEEHSVYWFKSSEKSHLGLIYTHEGRNNRCERKTNTQTNTCVYNLPIKSLNLSDNGMYYCAVASCGHILFGNGTKLGSEDEVTFPDFLVHVLSGVLAFTTTLSLLMGFLVWKMNKGNQSLTLAVSPNMVRYSAQKTVARGYQDADNLHYAAVHTQKSNRQRRQMNDTMNHCVYSSVRQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCJ5</accession>
    <name>A0A3P9BCJ5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malate dehydrogenase 1B, NAD (soluble)</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCJ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007630"/>
    <dbReference type="Ensembl" id="ENSMZET00005007947.1">
        <property type="protein sequence ID" value="ENSMZEP00005007630.1"/>
        <property type="gene ID" value="ENSMZEG00005005818.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063410"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016615">
        <property type="term" value="F:malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000144">
        <property type="entry name" value="Malate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="295"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="468" mass="52144" checksum="C2F29A09F3311951" modified="2019-02-13" version="1">MAKFVLAGKTDCPYYAKAELLADTLQQCLPDFKIHKISILPDEWKEWLGATCEKNNWKHEGSPLVWRELVEQGGKGMLLGGFNDFLEHCQDYYGITSDMTTNVMLSVAAENLEAKMNLIKEEQHRASLIQPLHVWITGALNPTCQVLIPSLLSPEVFPNVSAISLRLLDLEGNEEQLQSLRLEIEELAISMLHQVTTGTDLERAFRKADVILLLDDGGHDGENEGEEVKKKKVKVISERYKEYGQLIDATAKETVKVIVSGDSFLNLRCSLLVDSARSIDSHQFIAAAAQLENEAKAVLGKKMRMRPSDITDVIVWGNISGTFYIDLQRAKVFNHDGPITGPAFFSQPLLSIFPDRKWLETDFQHLVRRRRLAVTSKTGQAAATSAANGILTVLKAWNGASDPDLVSKCDCFGVILGHYSLPDGIVFSVPLTFTDGKWSVVSELTVENELKYRLELSASELQQVKLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFK9</accession>
    <name>A0A3P9BFK9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear autoantigenic sperm protein (histone-binding)</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024661598.1">
        <property type="nucleotide sequence ID" value="XM_024805830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BFK9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008699"/>
    <dbReference type="Ensembl" id="ENSMZET00005009039.1">
        <property type="protein sequence ID" value="ENSMZEP00005008699.1"/>
        <property type="gene ID" value="ENSMZEG00005006624.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016650"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="9">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="347"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="474" mass="51221" checksum="43601C9D69EEF726" modified="2019-02-13" version="1">MPEETSVASSSESAEEKPCSSTAAAAGSSVEVLEEAKKLIGTGKRHLVMGDVVSAVNVFQEACSMLAEKYGDTADECGEAFFLCGKSLLELARMENSVLGNALEGVPEESEEEEQPSSSNVESPDNLDEKTRDELRQQVYDAMAEKEKAEDPHSPVTGDEKSLTQETEMDGVSSVKSVREGSLGKETEIEQKADSSEEQTGNGTGVKPVRGCDEDKEETEDDDDDDDDDDDDDDDGEKNGQDKEEEEVGNLQLAWEMLEVAKVIYKRKESTEDQLMAAQAYLKLGEVSAESGNYPQALDDFQECLALQLKYLPPHIRLLAETHYHVATTLCYMDQYSQAIQHYNSSIKVIETRLAMLQEVIDAAEGADGAAEEKTELDELKLLLPDIREKVEDAKESQKTASAASQAIQQTLGGASTSSAFLCENGSTSSAAFATTSQVPVKTESSSSSKAVSDISHLVRKKSATQSASVESPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFL6</accession>
    <name>A0A3P9BFL6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RAS, dexamethasone-induced 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557571.1">
        <property type="nucleotide sequence ID" value="XM_004557514.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BFL6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008683"/>
    <dbReference type="Ensembl" id="ENSMZET00005009023.1">
        <property type="protein sequence ID" value="ENSMZEP00005008683.1"/>
        <property type="gene ID" value="ENSMZEG00005006609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475066"/>
    <dbReference type="KEGG" id="mze:101475066"/>
    <dbReference type="CTD" id="51655"/>
    <dbReference type="GeneTree" id="ENSGT00940000165566"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04143">
        <property type="entry name" value="Rhes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF5">
        <property type="entry name" value="DEXAMETHASONE-INDUCED RAS-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="266" mass="30613" checksum="98BE44617C1BAC37" modified="2019-02-13" version="1">MIKKMSPSESDFDIPAKNCYRMVILGSTKVGKSAIVSRFLNGRFDEQYTPTIEDFHRKVYSIKGDVYQLDILDTSGNHPFPAMRRLSILTGDVFLLVFSLDNRDSFQEVQRLKRQIYETKMCLKNKIKENIDVPLVICGNKGDREFHREVQKEEIEQLVAGDEKCAYFEISAKRNENVDKMFQTLFTLAKLPHEMSPDLHRKVSVQYCDMLHRKSLKNKKLKDIGEAYGVVTPCARRPSVHSDLMYIKEKAIGGGHGKDKERCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGY9</accession>
    <name>A0A3P9BGY9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Telethonin</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004566882.1">
        <property type="nucleotide sequence ID" value="XM_004566825.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGY9"/>
    <dbReference type="Ensembl" id="ENSMZET00005009506.1">
        <property type="protein sequence ID" value="ENSMZEP00005009157.1"/>
        <property type="gene ID" value="ENSMZEG00005006953.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470367"/>
    <dbReference type="KEGG" id="mze:101470367"/>
    <dbReference type="CTD" id="100151586"/>
    <dbReference type="GeneTree" id="ENSGT00390000012014"/>
    <dbReference type="OrthoDB" id="9949665at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031432">
        <property type="term" value="F:titin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070080">
        <property type="term" value="F:titin Z domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055008">
        <property type="term" value="P:cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055003">
        <property type="term" value="P:cardiac myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035995">
        <property type="term" value="P:detection of muscle stretch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048769">
        <property type="term" value="P:sarcomerogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030241">
        <property type="term" value="P:skeletal muscle myosin thick filament assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030240">
        <property type="term" value="P:skeletal muscle thin filament assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.160.10">
        <property type="entry name" value="titin domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015667">
        <property type="entry name" value="Telethonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023111">
        <property type="entry name" value="Titin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15143">
        <property type="entry name" value="TELETHONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15143:SF0">
        <property type="entry name" value="TELETHONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09470">
        <property type="entry name" value="Telethonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="164" mass="18954" checksum="AA4B160305D119B1" modified="2019-02-13" version="1">MHCVSRGGCYLVNSWCDLREENRWKKESYEACWVSLVLETRPQYRLKLSESDSIRRESYKQQQVAHFMVERSPSQILMLGSTSGAMTKHQLPLFNTSREVDRTTTSFRHTEEPVIKEKLIAGADRQGTGATTDQDLSKPVRVNFRASSLMSSPREISNRVQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHV2</accession>
    <name>A0A3P9BHV2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eva-1 homolog Ba (C. elegans)</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EVA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551045.1">
        <property type="nucleotide sequence ID" value="XM_004550988.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004551046.1">
        <property type="nucleotide sequence ID" value="XM_004550989.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774585.1">
        <property type="nucleotide sequence ID" value="XM_012919131.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BHV2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009468"/>
    <dbReference type="Ensembl" id="ENSMZET00005009826.1">
        <property type="protein sequence ID" value="ENSMZEP00005009468.1"/>
        <property type="gene ID" value="ENSMZEG00005007187.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479887"/>
    <dbReference type="KEGG" id="mze:101479887"/>
    <dbReference type="CTD" id="100004969"/>
    <dbReference type="GeneTree" id="ENSGT00940000154096"/>
    <dbReference type="OrthoDB" id="8956386at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052461">
        <property type="entry name" value="EVA1_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039500">
        <property type="entry name" value="EVA1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48422:SF2">
        <property type="entry name" value="PROTEIN EVA-1 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48422">
        <property type="entry name" value="PROTEIN EVA-1 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14851">
        <property type="entry name" value="FAM176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EVA1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="164" mass="18359" checksum="2E7D21FEFE8FC055" modified="2019-02-13" version="1">MDVKKKEMDLLSNSIAAYAHIKANPESFGLYFVLGVCFGLILTLCLLVIRISCKPRTTITPSTPEKKNLKDINEEDEDSDDDDEDEEVDDVEATVPLPTTEISVGNHTSQSDGTLSVNVFTSAEELERAQRLEERERIIREIWRNGQPDILGTGTGTIGRVHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ18</accession>
    <name>A0A3P9BJ18_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ18"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009925"/>
    <dbReference type="Ensembl" id="ENSMZET00005010291.1">
        <property type="protein sequence ID" value="ENSMZEP00005009925.1"/>
        <property type="gene ID" value="ENSMZEG00005007514.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153694"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="417" mass="46854" checksum="DCA7289AE0F6D0A9" modified="2019-02-13" version="1">MVQGLLMRSRREKYVTASASLHRAAHSRGPRRVANQIPDEILQDPELQEAIKALPANYNFEIHKTVWRVRQAKSKRVALQLPEGLQMFACIISDIIERFTDADTFVMGDVTYGACCVDDFTARALGADFMVHYGHSCLIPIDSTAGIKMLYVFVDIQMDNAHFLDTIKFNFSPGQSLALVSTIQFVAALQAVSAALKTEYDVHVPQCRPLSPGEILGCTSPRLERHVNAIVYLGDGRFHLESIMIANPDIPAYRYDPYSKVFSREYYDHEAMRAIRLQAIDKARLAQRWGLILGTLGRQGSPKVLEHLESKLQSLGKSFTRVLLSEIFPSKLALIPDVDAWVQIACPRLSIDWGTAFSKPLLSPYEAAVALQEVGWKEVYPMDFYSNQSLGPWAPNHPDNQPVRPARRQTQVNRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJE4</accession>
    <name>A0A3P9BJE4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
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                <person name="Malinsky M."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
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                <person name="Alcazar R."/>
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                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="16"/>
    <dbReference type="RefSeq" id="XP_004562351.2">
        <property type="nucleotide sequence ID" value="XM_004562294.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004562352.2">
        <property type="nucleotide sequence ID" value="XM_004562295.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004562353.2">
        <property type="nucleotide sequence ID" value="XM_004562296.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004562354.2">
        <property type="nucleotide sequence ID" value="XM_004562297.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004562355.2">
        <property type="nucleotide sequence ID" value="XM_004562298.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004562356.2">
        <property type="nucleotide sequence ID" value="XM_004562299.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BK80"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010330"/>
    <dbReference type="Ensembl" id="ENSMZET00005010701.1">
        <property type="protein sequence ID" value="ENSMZEP00005010330.1"/>
        <property type="gene ID" value="ENSMZEG00005007797.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101470743"/>
    <dbReference type="CTD" id="55146"/>
    <dbReference type="GeneTree" id="ENSGT00920000149163"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF466">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="17">
        <location>
            <begin position="152"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="348" mass="40295" checksum="C47683D8DB9213EB" modified="2019-02-13" version="1">MDFLTLFGIYVVVVLTCIALVCRYSGQQHSPLNSLYSFALKRLSSITPKWLQTFSQWTLHRLFHQRSNAFIYLHILLEGAVYAEFTYEVFGFCREMDTTLISLSVPYILLAIKTFFFYLCIKTDPGTVTKKKVAGQLHIYSYDRRLFHPGIICSTCQLVKPARSKHCRVCNRCVQRFDHHCVWVNNCIGAQNTRYFLLYLFSICAMACDIALLTVDMLLHVVLRTGLLGASYLDENGQRQPAGFLFVVQHLFLTFPRIVFMLGFLLFVFFLLAGYTMFHSFLAVVNQTSNEWYKSRGYVCQHCHPSTAADILCSPIPDHSKRYYYSRGVLRNLREIVFPPRLVQKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BKV0</accession>
    <name>A0A3P9BKV0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BKV0"/>
    <dbReference type="Ensembl" id="ENSMZET00005010657.1">
        <property type="protein sequence ID" value="ENSMZEP00005010286.1"/>
        <property type="gene ID" value="ENSMZEG00005007767.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163093"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Odorant receptor 131-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052921">
        <property type="entry name" value="GPCR1_Superfamily_Member"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF866">
        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="337" mass="37503" checksum="352313B32467BB97" modified="2019-02-13" version="1">MLISVLFSLRVRELCSSNNRGDWRSKFRGVLERVLFSTLTTLPCCLFLCINGIMLFTLRSKALFCETSRYILLYNLLFADTVQMALSQLLYIIAACRITLTYPVCGFLTMLANLTTVVSPVTLVVMSLERYVAVCYPLRHASIITITNTGVAIIVIWAIGSLNILTRVLLLLEFPFGALDSLQMKDFCSEIAMSGGSMSDDYDKAFTCALFISASVAITCSYIGVIVAARSASTDKASARKACNTLLLHLVQLGLSLSSTICNPLLTALARVLTRIVFVRIQNVFYVCIFLFPRCLSSLIYGIRDQSIRPVLIYYLCCRLKYSVIQPRLKAVIEVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BMA3</accession>
    <name>A0A3P9BMA3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RAS p21 protein activator 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BMA3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011053"/>
    <dbReference type="Ensembl" id="ENSMZET00005011436.1">
        <property type="protein sequence ID" value="ENSMZEP00005011053.1"/>
        <property type="gene ID" value="ENSMZEG00005008267.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158201"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05394">
        <property type="entry name" value="RasGAP_RASA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF21">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00107">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="127"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="6">
        <location>
            <begin position="331"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="776" mass="88310" checksum="B82DDF3AF249C9A1" modified="2019-02-13" version="1">TMAEDDDAKIRILQSLRGKICEAKNLGSVSGPNRQRDLCTFCTISLDQEEVFRTKVFDKSVCPFYGEDFYFEIPRPFQCLSFYVYAKSVFQRDLPVGKVSIRKDDLCKYSGKENWFSLQTVDPNSEVQGKVHLEMRLSEVITENGSTGQHISVRIIECKELPLISGQNCDPYATVSLVGPARSDQKKTKVKKKTSNPHFEETFFFEVTRSYSRRTQFNVEEEDIEKLEIKVDLWNNENLAQDVFLGETRVPVKILQSDHIHKAWYLLQPKGNGNKSKSDDLGSLRLKLTYIEDTVLPSACYTPLCTLLLKSPDVKPISASAAHILGDICRERYEVVLPMVRLLLHNNRFVPFVSAVAALELDNTQEANTIFRGNSLATRCIDDMMKIVGKNYLSVTLKPVIDEICESNKTCEIDPIKLKEGDNVEVNKENLQGYVQKVFSSITQSSSNCPPLMCDVFRSLRHLACKRFPGDPHVQYSAVSSFVFLRFFAVAVLSPHSFQLRSHHPDPEISRTLTLISKTIQTLGSWGSLSKKLSSFKETYMYDFFKSFQEEKCIEKVKKFLDEISSNVSKESSGLEDAVVLKEGEVQKRAQGRKPPGMKTFKKRWLRLTNRELSYHKHKGETSLLEWLEVLSQVSRCNEGRLATFHPSNYTSGAWQCCQSLSSNAPGCKPCTTTMLANLQLDIDCDREAERIFSLLSANDTKLQSMEDACASLAVYQGPQREPEEYSKFTIQEPKETFHTLKQLRNIMEELQRQHNSRNDVRQYGSLDNPIVGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BMR9</accession>
    <name>A0A3P9BMR9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Crystallin, gamma M6</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573883.1">
        <property type="nucleotide sequence ID" value="XM_004573826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BMR9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011234"/>
    <dbReference type="Ensembl" id="ENSMZET00005011623.1">
        <property type="protein sequence ID" value="ENSMZEP00005011234.1"/>
        <property type="gene ID" value="ENSMZEG00005008441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483471"/>
    <dbReference type="KEGG" id="mze:101483471"/>
    <dbReference type="GeneTree" id="ENSGT00940000164501"/>
    <dbReference type="OrthoDB" id="8407241at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000001">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000003">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF129">
        <property type="entry name" value="CRYSTALLIN, GAMMA M6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="175" mass="20941" checksum="2FFDA38715208C7A" modified="2019-02-13" version="1">MGKIIFYEDRNFQGRHHECMSDCADLHPYFNRCNSIRVESGCFMVYDRPHYLGHQYFLRRGEYSDNQRMIGINDCIRSCRMIPMHRGSYKIKLYERPDMAGQMQEVSDDCPNVQDRFRMSDINSCNVVDGHWLLYDQPNYRGRTYYLRPGEYRRYSDWGGASPRIGSLRRITDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BMU9</accession>
    <name>A0A3P9BMU9_9CICH</name>
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        <submittedName>
            <fullName evidence="10">Mucin-17</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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        <text evidence="2">Belongs to the TACC family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mitotic spindle organization"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:nuclear migration"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TACC_C"/>
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        </source>
    </evidence>
    <sequence length="3530" mass="381804" checksum="6F6BE4483E72BDC6" modified="2019-02-13" version="1">MQFCRKVLCQPCSARVTSPEEDMEYKMGSCIGIPHGKAEARAESSTQRDDGALLTEVSTSQHSLLSQPVLPDIPVITGVEESRGTAADQEDKEELEFPHDLLPSLDFSSELNIWESSLGAKTSSGDRKCEQVNPLLAGLQHHIEVSQPLLFQDTRPHGCDPLVADVQLLTQPAATPYPGNRPLAPSPSTFLDRELQEAFQECEEQLVSLGIVTPTQPCSPEPGTWCNEGNTTGKVMANKSSESSSPPPIVVQLGHSNGGHGNRNAHGNSETADSQKDTVVFSFRDYILGTVNNDGTAETENLKAEKEIKTDEEKEAPTQIQLEMPTYSAGEQPKQAVFSDHTNDLRQGNANSSASVGGSSTVDSDVVIRKKDTEAKTDKEENLSDDFSAGVCFETKVGNSAMETSERSPRLRDRDALPELQSKGQTGAGKHTVEQESDPYKQSSAGDKQAAQNKEAKKKRHRKKKKMEKSPETGQEARTAVQSENEVINAGNPTDSPSGPVICGQHPDNRLDYKEQLEGKPTSSSLLSSPHSSQDHLTPSACSPAPMRALLQKPHQSDNHNDPLSSINKSSNESLQWGQHVTGGETSNQNIPVTHVQNTAINQAASSDKRSDTQTCQASVTEAKILTPENHVPLSNSRTCVGESCMESVLEEALAVVTALPLTTPTLPEVIESEGEGESVRCDLVERVAARAVAESEEGVEERGTEKCLISADGERDEVLGSPSRLALICSQAKCSLAFSAKEGPAAAEESCTSKMPHNSAESEIKAPREATARSSRRKLSPAEEGDAEKEPQCLEAFINTSPLGLLTGSDCQDHIAAGSKREGEGGGEEVVEKGGLVSEHSSFSQPEGSASGLSSAQTERCPPTDVAESQLKSQSWRESIATITESICTEEEHLCRPRREHRGATISPLLLDAEQSYSKTNGGRRADLDQKLVSEEGLALGRTFEESSVTETNYSRVFPSLTSRQHLITSEQIPVKQQASNNQQVQPSSTTEAEIVESAAKLQVEAYSQSNSGSTAMSEVGVYLCGRSGGNRVHFMDAEKEMGSSSVDLKTMPVPALDCASLPPLTVHEQLRHPVFEASYTFTDFLNSKKPDIPMNPAPTKDEAAAFSEAQKDVCLAKGDTRTKETKENIATDQSHSDSLKTNTVDSQSVNSSQQLPRPAEETQTGNKGCFDVLQPPGSAISESNHLTFELVTAKAEAETQKDAAIVCLPKEEEEIKKVVAESKGTADIDQPQESPLSVTPVILEENKGNQHNCAPLSGVDTSSTSEPVTLTCAAPLQMKHCDPADQPVMQLGEKPPNEPVNPDITKAGEGPKSPTGSADPTKDAWVTSEVTASDESSTFVSNPAFELQPPGPMLSHLEFVTDSDASVSEKAYNCSADGDSSSDSRKVDAHKSREVTHTSLAQHAEIGDVYVNANEVLPKLENLNFDTKESAATSNVNSQLSQEENPIPPQPPSDAVTRNKPANVIPLSQTVPDSAGIKPIICEASIRDDITNVSYPFNSDLPANEVYDTIKGDNVKENHTMGDQTAMLFEEQKKQAKEAAMDNQKEAADSSKQQTGKTGTMPQQNNEADKETIEEIGALQPPHAYMGQKSELSLKDVKKEKEIKNTFESKSETETCSSSPSRFPGSSEDVLRADLESSSEPLTVYDSSLRQIPTAALECSSDSAPDLGAALGQSQSTPDPNCFAQQQEHHQQYLGSRHPTEAMSGGCLEGGEKANDQTQTLVKGVKGAPEEGDSSAGDICQSGSKDELAGDASMSNEGVIKSVKGEDASLEVHRLPSSLDSNEIDGRNASPDAGIAAGYSHVSETSQETDENESPGLEGSGRDLMPDTGFVSDLSDKDQQKCDLSAVCQEQSRKSELSENLVVSVEPVSQEHESSSFHIPILTKDSTASDAIHADFSPSTNQAGEISMHTCSSLPDPAAHPETGGEDFSAAVALKSTGSESVACESQDTVSRPRGLQRPNKTSATQNSPIEQTPIKGPDVEEMTKEDKEALDEGNVSEQGEEQNWIKVIDGGALGKQGVVHLAGSDKEMGSGSITVLGNSQSGEAQISTEVAVCHSDGNTGPCKARESDSDATEKMTADVDTGPSVVSSKCLEDFETLTHSEKPQDVVPLSKPPDDTVVKPTAAASRCESESLDRAPARRPPAEQVEAAEADTNWIKALREAASHSQSEQVNPVDALRPFPSLESPQQEFLTPTEEIAAPVRQEKTPPPELAAEETAEIPPVNLVKKPVDLPRPLKKAGDLLESAHEIAELSKPPQSIKVEEEETTKAELPEAAKKEEEEHPDEVQEPKRKQVTSTEVVNEEQARERTDEIPEPTANDNELVEPAKYEEQETTRPTTESPQSEEKPVSELPVELVEKPLDIQPVEPAEVLAEETAATEAVQDPAAELRDSGPSLGDKVESGHLAPASPQPLPSDHHLLPTHFRDTAEFPTSVPTLPEGHTLEALPTPPASPCPPHPAPASPPASSADPCEDVYPASAPCHIPLRSSDSDGAFETPESTTPVKAVSPAEPQIKQTTSDEKVEDTSITDPTSDFTAAELPCHSASNTFDENKPIAASGTYNIDFFAAESTTHTLTRSLSLQGGELDSSALLDGSPSGGFRPHSESFSVGTESAPGTLRRPKKGRPGSVKKKPLLRQNSNPESPRPDSSSSTPEIKKRAKPRTASPLQAQEETEGGSATPSPGGTQRKARKTRVETPPPLPEETNHTTQEESLIVPALPLCQEEIPLPESQADKEETPIPPSGSYKWDPDNFENINPFKTGGSKIANSPVLGRKEPVCAPISTPLESPPVPSEEPHYPSPPAPIREPVTNPEEQPIIPKRQSLRLEFDYSEESGEASHQASPPPKKLGKKPGAKMPLRKPKLGLKKAPPAQTEQLDNIPPASHNSNEDEIPATKASYTFELDKYEDPNLNPFTSRKNITNSPKLSRPPYNFDDSIDPFKSSNKLANSPPKTSASFELSSNDNDTENDNLGELEDQNQNKPAKKKKTPIKSNTFRVKRSPKKSPLSDPSQDLITADEPSSLHQQDDHATDEEKLASSTSHKWAALHDMDGDLNSDQQDFPQPCDLTSFVNENSLPKETPVQDYEIEYMEKIGSSSPPPSAKKPSLYLKLDSVSDNLTKNTCAHGSEPSSPCTGSFEEMEAQITAGMKTPVLSSRPGPEGSAADKGRKRESEVLSRTQSTEMEEQPPSQGPVEALAPALAMPLLDRLSECDDPLQYLEPDLAETNPTAFAQKLQEELVLAALRIEALQVAKNISQCPSLSTVTPQSRLKKPSTRRWNINGSPLLKVATDTWRCIWHRDVSSSLESGVSKNSLYSRTTASYIEGESPHLPRELDHSLGIAREEIVTKEKEVLEWQRKYEDSRQEVVEMRRIVAEYEKTIAQMIEDDQKEKSLSHHTIQQLIMEKDQALADLNSVEKSLADLFRRYEKMKDVLEGFRKNEEVLKKCAQEYLSRVRKEEQRYQALKIHAEEKLDRANAEIAQVRAKAKQEQAASQASLRKEQMKVDSLERTLEQKNKEIEELTKICDELIAKMGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BP12</accession>
    <name>A0A3P9BP12_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mismatch repair endonuclease PMS2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA mismatch repair protein PMS2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PMS1 protein homolog 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BP12"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011682"/>
    <dbReference type="Ensembl" id="ENSMZET00005012088.1">
        <property type="protein sequence ID" value="ENSMZEP00005011682.1"/>
        <property type="gene ID" value="ENSMZEG00005008759.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155381"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000032">
        <property type="entry name" value="mismatch repair endonuclease PMS2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.20:FF:000019">
        <property type="entry name" value="PMS1 homolog 2, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018141002" description="Mismatch repair endonuclease PMS2" evidence="15">
        <location>
            <begin position="28"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="17">
        <location>
            <begin position="255"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="16">
        <location>
            <begin position="708"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="530"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="892" mass="99320" checksum="A7BC3B333F963CE0" modified="2019-02-13" version="1">MHGKLARAFVHMDIFVFFKLLLPCTLEFNIDFLCCSSEPAGAIRAIDKHSVHQICSGQVVLTLATAVKELVENSIDAGATNIDVKLKESGAEQVEVADNGKGVEEANFEGLTLKHHTSKLRDFSDLIHVETFGFRGEALSSLCALSDLSVITCHESSQVGTKLVFDHKGHLVQRTPHPRQQGTTVSLQQLFSTLPVRHKEFQRNIKKEYAKMIHVLQSYCIISTGVRITCSNQNGQGKRSTVLSTTGSQSMRDNIGAIFGPKQLQSLLPFQQVSPTENVIEEYGLKGADLPKQLFSITGFVSQGDHGVGRSTTDRQFFFINSRPCDPLKVTKLVNEVYHMYNRHQYPFVALNVAVASECVDVNVTPDKRQIFLQEEKLLLAILKTSLIAIYEGGVNKISLNYTPAPSTNATSTSEPCRTVLSNENKAEREEDTESVILSPKSSLNLAGLKAAFSSHYSSSSGKSSKEKASGSGTTQKTLQSFFKDPVKTSCNSSLKSPLKYTRQLDKCSSAGKSVLDGFRYRVMSCEDTDSQKDSAGSSCNTAEAKPDIQCSDLESSPPKVDRTSVNNETFKETSGNIHTVPEDPELETEACTPYEDSAVSPEAKRARKDDPHFPSEEESSTFSNAGEKPPLTVDAPVSLQRRTVHLQFSLAELAKKMRRLHDQQKQRAGEELLYRRFRAKINPGENQSAEEELKKEISKEMFKEMEIIGQFNLGFIITKLKSDLFMIDQHATDEKYNFEMLQQHTVLQGQKLIVPQKLHLTAVSENVLIENIEIFKGNGFEFLIDEDAQVMERVKLVSLPTSKNWTFGPSDIEELIFMLSDSPGVMCRPSRVRQMFASRACRKSVMIGTALSVNEMKKLVVHMGELEHPWNCPHGRPTMRHLANLDVISQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRY4</accession>
    <name>A0A3P9BRY4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Distal-less homeobox 3b</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the distal-less homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562444.1">
        <property type="nucleotide sequence ID" value="XM_004562387.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRY4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012723"/>
    <dbReference type="Ensembl" id="ENSMZET00005013167.1">
        <property type="protein sequence ID" value="ENSMZEP00005012723.1"/>
        <property type="gene ID" value="ENSMZEG00005009550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470245"/>
    <dbReference type="KEGG" id="mze:101470245"/>
    <dbReference type="CTD" id="30585"/>
    <dbReference type="GeneTree" id="ENSGT00940000158951"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042667">
        <property type="term" value="P:auditory receptor cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048703">
        <property type="term" value="P:embryonic viscerocranium morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035270">
        <property type="term" value="P:endocrine system development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:inner ear receptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070306">
        <property type="term" value="P:lens fiber cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030910">
        <property type="term" value="P:olfactory placode formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043049">
        <property type="term" value="P:otic placode formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:otolith development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903010">
        <property type="term" value="P:regulation of bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034505">
        <property type="term" value="P:tooth mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021559">
        <property type="term" value="P:trigeminal nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000048">
        <property type="entry name" value="Distal-less homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022135">
        <property type="entry name" value="Distal-less_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF28">
        <property type="entry name" value="HOMEOBOX PROTEIN DLX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12413">
        <property type="entry name" value="DLL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="131"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="281" mass="31556" checksum="D6DFA3339FB257D2" modified="2019-02-13" version="1">MSAGQTYEKKIASILTDLPGSMSCHPNSKDSPTLPESSVTDMGYYSGQTAHGHHEYYQSQPYGQPMNSYHHQFNLNGMGAAGAYATKSEYPYTNGYRQYGHYNRDHLQASPPGSVKEEPEPEVRMVNGKPKKIRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNASDSMACNSPPSPAVWDNSSTPQNTPISRPQVPQPTHSSSPPYLEDYNNHWYQQGSHLQHPGAVHHPVPQQSVGAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BU96</accession>
    <name>A0A3P9BU96_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Antp homeobox family. Proboscipedia subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BU96"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013477"/>
    <dbReference type="Ensembl" id="ENSMZET00005013935.1">
        <property type="protein sequence ID" value="ENSMZEP00005013477.1"/>
        <property type="gene ID" value="ENSMZEG00005010136.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155029"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000145">
        <property type="entry name" value="homeobox protein Hox-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="104"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="106"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="226"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="328" mass="36090" checksum="8E7011902437DCCE" modified="2019-02-13" version="1">MKIRSSIKSSTLSRPTLIPPPFEQTIPSLNPGSHPRHGRPRHSPDGCSPLPTAFLPPEYPWMREKKASKRNHLPTSTATTISNGPVCFSPKGSPEIVESGGGGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQSKENHNGDGKGLSAEDGIHSEEEDEAPQYEQSGALLERDTCSFQNNTQQLHNGESMSFAAAPLNSNDKNLKHFPNPSPTVPGCMSTMGPGSASGPDNGDSPPALDVSLHDFQPFSSDSCLQLSDAASPSLSESLDSPVDISTDSFYFFSESLTTIDLQHLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVG6</accession>
    <name>A0A3P9BVG6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVG6"/>
    <dbReference type="Ensembl" id="ENSMZET00005014095.1">
        <property type="protein sequence ID" value="ENSMZEP00005013631.1"/>
        <property type="gene ID" value="ENSMZEG00005010263.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161369"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052921">
        <property type="entry name" value="GPCR1_Superfamily_Member"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF876">
        <property type="entry name" value="OLFACTORY RECEPTOR 10K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0552">Olfaction</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 6" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="315" mass="35944" checksum="97DEB5E8F7474660" modified="2019-02-13" version="1">MSLQNASINVTHFIIGGFDTLSRPIAVGVVILIVYLLAVLANMINIMFIISDKRLHKPMYLLICNLAVVDIMYTSSCSPTMIGVLLAGVNTISYMACLIQMCVGALGTSMESFVLAIMALDRFIAIIYPFQYQSYLTNTRVLVLTFIVWFVAWCFVFYMPATVVLLPHCSSRLRYTFCDFAAVLRTTCVNPEKYFNEVAIVSFFIFFFTFIFICLSYCGILLFVKLSSNNEKKKMGSTLVSHLICVFVHYCPAFVRNIFTRFGVVLTLEERQGLLIGAVLGPCLVNPFVYFLRTKEIKQKFYKIFKNVTFFFFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BW61</accession>
    <name>A0A3P9BW61_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microsomal glutathione S-transferase 1</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer; The trimer binds only one molecule of glutathione.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAPEG family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004576108.1">
        <property type="nucleotide sequence ID" value="XM_004576051.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004576109.1">
        <property type="nucleotide sequence ID" value="XM_004576052.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BW61"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013881"/>
    <dbReference type="Ensembl" id="ENSMZET00005014351.1">
        <property type="protein sequence ID" value="ENSMZEP00005013881.1"/>
        <property type="gene ID" value="ENSMZEG00005010466.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005014353.1">
        <property type="protein sequence ID" value="ENSMZEP00005013883.1"/>
        <property type="gene ID" value="ENSMZEG00005010466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476898"/>
    <dbReference type="KEGG" id="mze:101476898"/>
    <dbReference type="CTD" id="431762"/>
    <dbReference type="GeneTree" id="ENSGT00390000011980"/>
    <dbReference type="OrthoDB" id="193139at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF6">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="151" mass="17154" checksum="D23B9E93DA37EEB3" modified="2019-02-13" version="1">MAELMENEVVRAFSTYAVIVVVKMLLMGPMTGYYRFTRGSFSNEEDVARKSAEEKKKLLKTHPDVERVRRCHQNDLENIIPFVIVGLLYALTGPELSVALLHFRIFTGARIFHTIAYIGALPQPSRALSWVVGMLVTFSMAYRVLNTVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BX27</accession>
    <name>A0A3P9BX27_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SPARC related modular calcium binding 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559730.1">
        <property type="nucleotide sequence ID" value="XM_004559673.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BX27"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014550"/>
    <dbReference type="Ensembl" id="ENSMZET00005015033.1">
        <property type="protein sequence ID" value="ENSMZEP00005014550.1"/>
        <property type="gene ID" value="ENSMZEG00005010946.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486345"/>
    <dbReference type="KEGG" id="mze:101486345"/>
    <dbReference type="CTD" id="64094"/>
    <dbReference type="GeneTree" id="ENSGT00390000018436"/>
    <dbReference type="OrthoDB" id="5986054at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000076">
        <property type="entry name" value="SPARC-related modular calcium binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000004">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000003">
        <property type="entry name" value="SPARC-related modular calcium-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF21">
        <property type="entry name" value="SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16597">
        <property type="entry name" value="Thyroglob_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
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    </dbReference>
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        <property type="entry name" value="EF-hand"/>
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    </dbReference>
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        <property type="entry name" value="Thyroglobulin type-1 domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KAZAL_2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THYROGLOBULIN_1_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018195704" evidence="11">
        <location>
            <begin position="21"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="13">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="12">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="12">
        <location>
            <begin position="205"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
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    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="243"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="429" mass="47739" checksum="B42DE99AA287EE8B" modified="2019-02-13" version="1">MRICPLLVFLCLQCAGGVQKFSALKFLRVDQDKDCNMECSGAPRKPLCASDGRTFTSRCEYLRAKCRDSQLEVSRGPCKDTSRCVAEKKYTEQQAKKLFPQVFVPVCNPDGTYSEVQCHSYTGYCWCVTPNGRPISGSAVANKKPRCQGSKQEKTTTREPGKSDDTDLVIDPQPPEHEEDSNSQYPTLWTEQVRSRQNNRTRAPSSSCDQEKLSAQEEARQHKNDAVFVPDCAQGGLYKPVQCHPSTGYCWCVLVDTGRPIPGTSTRYEQPKCDGNARAHPAKPKDHYKSRHLQGCPGAKKTEFLTSVLDALSTDMVHAVTDPASAGRVAEPDPSHTLEERVVHWYFSQLDKNSSGDIGKKEIKPFKRFLRKKSKPKKCVKKFVEYCDISNDKALSLQELMGCLGVTKEEGSIPGEGLTSKLNPSKKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYH2</accession>
    <name>A0A3P9BYH2_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Si:dkeyp-81f3.4</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYH2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014939"/>
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        <property type="protein sequence ID" value="ENSMZEP00005014939.1"/>
        <property type="gene ID" value="ENSMZEG00005011229.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003444"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025663">
        <property type="entry name" value="AKAP_28"/>
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    <dbReference type="PANTHER" id="PTHR35075">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35075:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKAP28"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="190" mass="21893" checksum="7F9CCA18F90A24CA" modified="2019-02-13" version="1">METVQQTIQMTATFIKILLKRGTTMNLTTESAQLVKTLLDRHHRTEKAEMDDIPWAACKDFTVNVGEKQIGAYIKTWELPSCWLYSVDFVCSTEEEHRTFHHYRARFSTPTPRKPIRGTASVYFVVDVSKVKPQTLPVEVSFIVESNKLVHTPGRTRFRENFLCNLAYISLMSLFPFIKNGFLTAPLPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C203</accession>
    <name>A0A3P9C203_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-uridine aminocarboxypropyltransferase 1</fullName>
            <ecNumber evidence="2">2.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DTW domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TDD superfamily. DTWD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004543563.1">
        <property type="nucleotide sequence ID" value="XM_004543506.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C203"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016147"/>
    <dbReference type="Ensembl" id="ENSMZET00005016662.1">
        <property type="protein sequence ID" value="ENSMZEP00005016147.1"/>
        <property type="gene ID" value="ENSMZEG00005012129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476577"/>
    <dbReference type="KEGG" id="mze:101476577"/>
    <dbReference type="CTD" id="56986"/>
    <dbReference type="GeneTree" id="ENSGT00940000153766"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:tRNA modification"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DTW"/>
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        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
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    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF8">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DTW"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="13">
        <location>
            <begin position="78"/>
            <end position="309"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
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        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="179"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="189"/>
            <end position="200"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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            <dbReference type="ARBA" id="ARBA00022694"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00037050"/>
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            <dbReference type="ARBA" id="ARBA00039242"/>
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            <dbReference type="ARBA" id="ARBA00042508"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM01144"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016147.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="314" mass="35592" checksum="FFE7DB2A236759E0" modified="2019-02-13" version="1">MSVLVLQDKSVNRAKMSGLDQDQRHHPSCREKTLASDSSDSRELPSQQLQGLKLASHAVLEEAQQRGRLKCSKCGGSRMFFCYTCCSLVGMSLQDVPTVKLPVKIDIIKHPNETDGKSTAIHAKILAPSDITIYTYPCIPEYQKDKVVLVFPGPRAVSVQDMMKCLHDRSHDSADEPCRKRLKTEQVQGSTRTSESSESGTPDEAKSSVSKVDPLHRVVFIDSTWNQTNKISTDERLQDLLQVELKMRKTCFWRHQKGKPDTYLATIEAIYYFLMDFHEHCLDEEYSGEYDNLLFFYSYLHSIVNKAKTSAGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2C3</accession>
    <name>A0A3P9C2C3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004564476.1">
        <property type="nucleotide sequence ID" value="XM_004564419.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2C3"/>
    <dbReference type="SMR" id="A0A3P9C2C3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016036"/>
    <dbReference type="Ensembl" id="ENSMZET00005016549.1">
        <property type="protein sequence ID" value="ENSMZEP00005016036.1"/>
        <property type="gene ID" value="ENSMZEG00005012046.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483419"/>
    <dbReference type="KEGG" id="mze:101483419"/>
    <dbReference type="CTD" id="8731"/>
    <dbReference type="GeneTree" id="ENSGT00390000002368"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11 13" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="15">
        <location>
            <begin position="72"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        <location>
            <position position="110"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    </feature>
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        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
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        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
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    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
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        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="381" mass="43884" checksum="9FF12C6B089ECAB7" modified="2019-02-13" version="1">MELQSRQTETMEEATQTRGAQQEENSGMKRKHVEDEEEKMSPSKKQVLDHGVKVASHYNQLQEVGRAARSRSRIFFMRNFNNWLKSVLIGEILEQVRGAGSQQVSVLDLGCGKGGDLLKWRRGGIDHLVCADIAGVSVEQCQIRYDEMKKKSHRNEKIFTAEFITADCSKELLSEKLDDAELMFDICSCQFVYHYSFESEQKANMMLRNACERLKPGGYFIGTTPDAFELVKRLEASDSLSFGNEVFKVTFQSKGSYPLFGCQYHFNLEEVVNVPEFLVYFPLFEHMAKQYNMQLVLKQRFADFFEEKVKKENHRSLMMKMMALEPFPSEDGLQASDSAEEYCHAKEHCDRADVRTPLGTLSRSEWEATSIYLVFVFQKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2F4</accession>
    <name>A0A3P9C2F4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2F4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016440"/>
    <dbReference type="Ensembl" id="ENSMZET00005016961.1">
        <property type="protein sequence ID" value="ENSMZEP00005016440.1"/>
        <property type="gene ID" value="ENSMZEG00005012341.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230401"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000011">
        <property type="entry name" value="Putative heat shock protein HSP 90-alpha A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13358" checksum="294388F9FE3CE13F" modified="2019-02-13" version="1">MKSQALRDNSTLGYMTAKKHLEINPSHPIIETLREKAEADKNDKAVKDLVILLFETALLSSGFTLEDPQTHANRIYRMIKLGLGIDDDDSAVEDIIQPTDEDMPVLEGDDDTSRMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2J3</accession>
    <name>A0A3P9C2J3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor Maf</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539465.1">
        <property type="nucleotide sequence ID" value="XM_004539408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2J3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016324"/>
    <dbReference type="Ensembl" id="ENSMZET00005016843.1">
        <property type="protein sequence ID" value="ENSMZEP00005016324.1"/>
        <property type="gene ID" value="ENSMZEG00005012264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477682"/>
    <dbReference type="KEGG" id="mze:101477682"/>
    <dbReference type="GeneTree" id="ENSGT00940000161531"/>
    <dbReference type="OrthoDB" id="5974330at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000016">
        <property type="entry name" value="MAF bZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013592">
        <property type="entry name" value="Maf_TF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08383">
        <property type="entry name" value="Maf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="237"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="331" mass="36669" checksum="2E9EA14604FD418E" modified="2019-02-13" version="1">MASELAMSNSDLPTSPLAMEYVNDFDLMKFEVKKEPVEPDRNISQCSRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKTHIEDFYWMSGYQQQLNPEALGFSPEDAVEALINSSHQLQSFDGYARGQQFAGAAGGGSTMAGEEMGSAAAVVSAVIAAAAAQNGAQHHHHHHHHHSSSHHQAPGVQSNGTSGTNHPHMRLEERFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLEGEKTQLLQQVEHLKQEISRLVRERDAYKEKYEKLISNGFRENGSSSDNNPSSPEFFMSSRKFLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C5S4</accession>
    <name>A0A3P9C5S4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAG family molecular chaperone regulator 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004542998.1">
        <property type="nucleotide sequence ID" value="XM_004542941.4"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024799386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C5S4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017628"/>
    <dbReference type="Ensembl" id="ENSMZET00005018194.1">
        <property type="protein sequence ID" value="ENSMZEP00005017628.1"/>
        <property type="gene ID" value="ENSMZEG00005013264.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005027720.1">
        <property type="protein sequence ID" value="ENSMZEP00005026857.1"/>
        <property type="gene ID" value="ENSMZEG00005020034.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476000"/>
    <dbReference type="KEGG" id="mze:101476000"/>
    <dbReference type="KEGG" id="mze:112430881"/>
    <dbReference type="CTD" id="573"/>
    <dbReference type="GeneTree" id="ENSGT00450000040296"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01812">
        <property type="entry name" value="Ubl_BAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAG-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037029">
        <property type="entry name" value="BAG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="108"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="207" mass="22803" checksum="D0075C2D1AB05BDD" modified="2019-02-13" version="1">MSEQTITMTVAYGSSKHSITLTGHEDGKGPTVKDLSDALAQATGVPPASQKLIFKGKSLKDMEESLSSYGIKEGCKLMMIGKRNSPEEEAELRKLKDIEKCVEQMAKKLEKVDGELTGLKNGFLAKDLQAEALGKLDHRVKIAAEQFMKILEEIDAMSVPENFNDCRMKKKGLIKTVQDFLAQCDKIEACISDHLSKIQSKNLALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6K9</accession>
    <name>A0A3P9C6K9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine zipper and CTNNBIP1 domain containing</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTNNBIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554245.1">
        <property type="nucleotide sequence ID" value="XM_004554188.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C6K9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017903"/>
    <dbReference type="Ensembl" id="ENSMZET00005018486.1">
        <property type="protein sequence ID" value="ENSMZEP00005017903.1"/>
        <property type="gene ID" value="ENSMZEG00005013465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466633"/>
    <dbReference type="KEGG" id="mze:101466633"/>
    <dbReference type="CTD" id="84328"/>
    <dbReference type="GeneTree" id="ENSGT00940000159001"/>
    <dbReference type="OrthoDB" id="10262856at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.490">
        <property type="entry name" value="Beta-catenin-interacting ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009428">
        <property type="entry name" value="ICAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036911">
        <property type="entry name" value="ICAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040065">
        <property type="entry name" value="LZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505:SF8">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06384">
        <property type="entry name" value="ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81730">
        <property type="entry name" value="beta-catenin-interacting protein ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-catenin-interacting ICAT" evidence="3">
        <location>
            <begin position="113"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="6"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="189" mass="21402" checksum="2DB16B2548A4AAE7" modified="2019-02-13" version="1">MASRGKSETGKLRQNMEEQLDRLMQQLQDLEECREDLDEEEYEETKKETLEQLGEFNDSLKKIMSGDMTLVDELSGMQLAIQAAISQAFKTPEVIRLFAKKQPGQLRSRLAEMDRDVMVGKLSRDVYTQQKMEILTALRKLGEKLTPENETFLTENATATLSQFEKVTANQGSEDKIMALASSGVKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7Q0</accession>
    <name>A0A3P9C7Q0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Charged multivesicular body protein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
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                <person name="Przybylski D."/>
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                <person name="Santos M.E."/>
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                <person name="Okada N."/>
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                <person name="Meyer A."/>
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                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="2">Belongs to the SNF7 family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
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    </evidence>
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        <source>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
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                <person name="Malinsky M."/>
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                <person name="Russell P."/>
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                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
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                <person name="Salzburger W."/>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
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                <person name="Streelman J.T."/>
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</entry>
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    <name>A0A3P9C851_9CICH</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
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                <person name="Malinsky M."/>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Streelman J.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Tfc3-like"/>
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    <dbReference type="InterPro" id="IPR007309">
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23704">
        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="648"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="760"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="827"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1221"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1569"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1733"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1973"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="761"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1235"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1261"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1582"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1733"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1973"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2006"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2035"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2080"/>
            <end position="2094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2218" mass="251310" checksum="0B7A44D526A399FA" modified="2019-02-13" version="1">MDLLSIVVDEVALEGLDGITIPTLWIRLEDRQPGFPLKLDDCTKELIWKSLVINSDLLFYELPEERDDVVLTDRFKDIDAETGIEVTDSFTDTPKDIYPIDVVENKDGIQGSCAFFKTRKDVTKQVRSKSPLTPLVSLSEALERYGRKLVVVASQCLRYRALIGSESDPDVKLGSDSYCVLERVGRARWQGELQRDLHGGSFKVDARKFHYFRKSLVRYQLVTMQSYVRRMKTGQQQHSILLLLKRFHVNRRTKYDILMEVTSNFLQQCPNQFSTVIMLREQLVNVDDRTYLRLFKYMRASKLIEFCRFPLEELDPSAGPRTNKNGSKVTVRCVRLLKPYIKKGVAEEDDDDDEDEDDDGGAGRGGLLTEGRIMEKDLLTQAYHIILSSGTKGIPQRDIAFRLNVSKLEARMLWRRLEKDGLIKGFMEDEGRQRTTKFISHKCVGSSNQLQLFAKEQERQMLLFSSAPQTSSAEPTSPKTPSSSKAPVKGSSRTPEAKKNKKEVKGRSKEAEEGGQTSEDGKGNSREEGLDGNESKVRENSGARRKTTGENGSMTAEHTQPDVPVMQSAPAECETSVCSKPATHGTPDSVSGAVTAPVEEKEETSSTDASSLHQSETPNAADNAAPITVVVKSIPSPKKASVTRERSHETYRLLRRKNLIVEAVCNLRIIEGLFQLQKMINDDEKQDGVSSKCCKKTIVRLVHCLAREGLLKIYTTTVVQDGMTRKVEMIVHPSIQPNNDRVKQVIEQVRFRISSSSAVLRHAEDRAREQEKEADKKKAIIDDDPDFKPTRVPGLSKTYGFQPKMHRLRMMHTFLWYLIYGHPLRHNCSSSDSTSQSSSGADGSDPAAKPADSKAQQDLKEAESSTPADRPTPLSDSVGTGCDGRKSADSSLSNMEVASGDEGEEQKDSYSQSDMKVYLDEDSWKRFIPPVRVHEEYSSGWAMVGDLLLCLPLSVFVQIIQVTYKVEGLEEYLNDPVKQHHLVRALPARMRRRLLYKRKYIFVFHENLLKLVYMGLLQFGPIEKFMEKDQVFVYLKRNATIVDTTNTEPHYWLVTECLEKPFERRPYVFNTADDLEKYWFDLMCVCLNTPLGVVRCKRNTTDEETTPSFVQERHVFAGMAYLLKGSTEVCDDGLIPGDGKGAGGLDSEFFGHLKRNWFWTNQLLSVNMRQSGLEAQDNKTRLKSLLSKDALRFALKAGGTATPRYVTSKRPARAEKVQVGIEPASRNQRVVGGKGQKRKRTKKDVVKVPRKKKKEPKKRTPAHDETDHQALKRMTRQRVNWTVQEDSLVMLCCVAADLLNSKLKRQFVPHCVVRDLLHAEFEISSDKTSVAVGRRSRYILKNPQTLLNYRICLAEVYQDKSLMSLLEKEKPADPEKPEDCAKVFSEYIRLLRQKFSTIVNAHDLIIPDTKQQLLSRFKVSAIDSGKKLPYKDTLNSTDDIHSVVLHNLIQSTLAMTNNQMKTSRSFQIFHLYSQYDQELLCKVFIQCRKRGLVNRRRISQQFGPKKNRALPILPMSYQLSQSYFRCFSWRFPHSLCTDSFRFLRSLIDNGTHDDRPIITLYNETEYRSQNGEEVLETKTGSKSKEHGGKEADRPASEPERAKDVTTKEGDDNQGEIKGDESIKDADTNNEKTDVSSKPDEQKKPDDSSTSGSGEEAPGVSATSNTVPPASDEPPDVSDMLKFSLQSPGGACLVSLSLMSLGLLNVYASIPKQMVVVDSNLVDKDVVKSMAELVEEEEEDDDDGDDYDGKKRQQVKAQKASHTKYLMMRGYCTPGIVKVRNLNTNDSIVMESCIMRLQLRNTPAHSLFSEENFAPLDLTKCGPSLLPSNLTSFVRSASFSPPSVEECYRRFVNQKGYTPRDIEACTQIMRSLDEAGERGWDAYDFLEAHANLLERQSGRSRKLQQYMEELEEEGQVVKVGSLSVRWVLMKLAGPWLLTVSSKHWSQSSTASHPFLEKKQTIPFIRKRCSREFQVEKEEPPAKRLAVDREDVADKEDVDGVPSNQETNEEKQLEQLERPMERADESRGDQLLLLEEEGGKQIQEEEKQAAERKKTTDAERRQDNRKEQRLRRGRKEDENNDEACSSSTGPDTDAETSFISRPWRLVDGKVNRQVCKGMLEAVLYHIMSQPGLTHQALVEHYKDLLQPVAVQDLVQALIELGCVTKKTLAKSPKPSLFTRPAQQRKSERQPDIVMYEPTISCCLRLCRVLPNERTWNCCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9A6</accession>
    <name>A0A3P9C9A6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease domain-containing 1 protein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9A6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018858"/>
    <dbReference type="Ensembl" id="ENSMZET00005019464.1">
        <property type="protein sequence ID" value="ENSMZEP00005018858.1"/>
        <property type="gene ID" value="ENSMZEG00005014156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234592"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039015">
        <property type="entry name" value="ENDOD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472:SF18">
        <property type="entry name" value="ENDONUCLEASE DOMAIN-CONTAINING 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21472">
        <property type="entry name" value="ENDONUCLEASE DOMAIN-CONTAINING 1 PROTEIN ENDOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018068189" evidence="1">
        <location>
            <begin position="24"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="292" mass="34142" checksum="E1D45858A1996BB2" modified="2019-02-13" version="1">MWIIDSFIYLFLSLFNLKSVVFYGEITTDFKPCIEFFYAETIPQGISGDYQALCQHYENQYHFATLYDRNRRIPLYHSAYILSPGDGPRPKNTNWMIEPRLVSDKVNTGMKYQKHPDQNVKNSQAVNEDYRNSGYSRGHLAPSGHQQTEEDKEATFTLTNIVPQMEKFNNGPWSLQEEKMLERFNVCMPKMYVITGVMPYEKDEPKINNRVTVPEYFWTAYCCPTFTAGPDQNYFPTYAAVGRNDPNSKDDILKKKPTQDGYDVKEMSLEDLEKILQKWLKMPEMSLFKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CA64</accession>
    <name>A0A3P9CA64_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Taste receptor type 1 member 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004548926.1">
        <property type="nucleotide sequence ID" value="XM_004548869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CA64"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018786"/>
    <dbReference type="Ensembl" id="ENSMZET00005019389.1">
        <property type="protein sequence ID" value="ENSMZEP00005018786.1"/>
        <property type="gene ID" value="ENSMZEG00005014091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465839"/>
    <dbReference type="KEGG" id="mze:101465839"/>
    <dbReference type="GeneTree" id="ENSGT00940000160679"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050916">
        <property type="term" value="P:sensory perception of sweet taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050917">
        <property type="term" value="P:sensory perception of umami taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15290">
        <property type="entry name" value="7tmC_TAS1R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000004">
        <property type="entry name" value="Taste receptor type 1 member 3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF435">
        <property type="entry name" value="TASTE RECEPTOR TYPE 1 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00592">
        <property type="entry name" value="CASENSINGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017951843" description="Taste receptor type 1 member 3" evidence="14">
        <location>
            <begin position="20"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="15">
        <location>
            <begin position="569"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="858" mass="95526" checksum="5BFFA7DCE18A0875" modified="2019-02-13" version="1">MALCLPLLVLCCFFRVSFSESFPEWFSNISANLFSLPGDIMLGGLFPINDLNSNVSDITEPNQITCDRVNDLGLGLAIAMKYAVDEINGNQTLLPGIKLGYEIYDTCSQSAIIVKPTLSFLTEKSSKELSVRCNYTTYETSVAAVIGPYTSKMVSFIGKLLGFFLMPQISYGATSDKFSDDVSYPSFFRTVPSDKWQVDVIIKLIEEFGWNWVAIVGSDEEYGQEGVQMFTKFADNTSICVAYQGLIPVYTDPVPMVKTIIHNIQMTNVRVVVVFSLPEQSEIFFKEVIRSNLTAVWIGTTSWAIDAQVTSLPDIETVGTIIAFIDKTDTLGLFTDYAMELFKKLSEERIKTSTPATNLYNTNNPCPQCWNLSPDNITLVEAPAVQMSAFSVYAAVYSVAQALHNLLECNLTACQWGSRSKIYPWKLLEALRKTSININSTHLEFDQYGNPNIGYDVIQWVWTNSSQVDIRTVGEYSEQELHISKNHFEWHTAEVPTSTCSANCGKGQVHRVKGFHSCCFDCIDCLAGTYQANKDDTQCTKCPNRQWSQHRSTNCTDPIFKFFEWHSQDAVIMMLVGALLLICQGSVGVLFLMQRGTPLVMASGGPLSFVAVFGLMGACLSLLLFLGAPGDVVCRLQLPFTSIFQTLTLSIILLFSLQILYETEFPEMAASHLHLLRGPVSWLFVLICCAVQAGLCGWFVQEGPSLSGYVANMTIDFVESFLSCPVSPLIGFALMQGFNGVMALASFMCTFMAVKPLHQYNLARDITFSTLTYCVIWVIFIPIYIGNNSSANKNRSVVHVYFSLASNFGLLAAYYFPKCYLLLRKPDLNTPKYFCTFLEGVPPTQTEEEPQPKAQEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBY8</accession>
    <name>A0A3P9CBY8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pro-melanin-concentrating hormone, like</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in skin pigmentation by antagonizing the action of melanotropin alpha. Induces melanin concentration within the melanophores. May participate in the control of the hypothalamo-pituitary adrenal gland axis by inhibiting the release of ACTH.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538524.1">
        <property type="nucleotide sequence ID" value="XM_004538467.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBY8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019632"/>
    <dbReference type="Ensembl" id="ENSMZET00005020261.1">
        <property type="protein sequence ID" value="ENSMZEP00005019632.1"/>
        <property type="gene ID" value="ENSMZEG00005014734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482942"/>
    <dbReference type="KEGG" id="mze:101482942"/>
    <dbReference type="CTD" id="100216485"/>
    <dbReference type="GeneTree" id="ENSGT00390000004984"/>
    <dbReference type="OrthoDB" id="8639774at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030354">
        <property type="term" value="F:melanin-concentrating hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031777">
        <property type="term" value="F:type 1 melanin-concentrating hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
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        <property type="term" value="P:neuropeptide signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Prepro-melanin_conc_hormone"/>
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        <property type="entry name" value="MELANIN-CONCENTRATING HORMONE"/>
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        <property type="entry name" value="PRO-MCH"/>
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        <property type="entry name" value="PROMCHFAMILY"/>
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    <keyword evidence="3" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018271323" evidence="4">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="136" mass="15434" checksum="815C40EE58F85C67" modified="2019-02-13" version="1">MRQSRLSIIFAVALFFKCYALTVALPTAKAEDGSLEQDAFTSLLNDEATENSLGDAELSSMTKSRAPKVIVIATDANLWRDLRVLHNGLPLYKRRVDENNQVVEHKDVGQDLTIPIHRRDTMRCMVGRVYRPCWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCA3</accession>
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        <submittedName>
            <fullName evidence="1">Sperm associated antigen 8</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="LG7"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 8"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF22584">
        <property type="entry name" value="CFAP143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="186" mass="20872" checksum="EC70C2239420ECAE" modified="2019-02-13" version="1">MTEQTAAVGHKVGKPMLHNWVEERAIADLHTEDPKTHKHIHGHKGILTIDLESKMESVTTLKAAYVAPKTPVGRLQGIRGELLKKHTAQMISEKIHADLNPLTPKTEYCSTTQKDFCVEGFVPHKPETTRVHDYKTDQAITFWSENCQRIQGVTAARSSKGPFRKSALFSTPITERLDEIDLPPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEE7</accession>
    <name>A0A3P9CEE7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="207" mass="24336" checksum="1005C96F676DD06B" modified="2019-02-13" version="1">LVLGRGYCASSALSVWVPCSLRRPFLSHLRHFLSHFFLSHLRHFLSHLRHFLSRLRHFLSHLRHFLSRLRHFLSRLRHFLSHLRHFLSRLRHFLSHLRHFLSHRGPASSAALSSSIFILLFASFPLHWFYFCLSPDVLTVLCHLTFSFPLLPPSGLSIRSVCWRADRILAGTQDSEIFEVRKKTKPHAVPSLRRRVSKSFIFVKTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFC2</accession>
    <name>A0A3P9CFC2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Zinc finger matrin-type protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with dsRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CFC2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020561"/>
    <dbReference type="Ensembl" id="ENSMZET00005021233.1">
        <property type="protein sequence ID" value="ENSMZEP00005020561.1"/>
        <property type="gene ID" value="ENSMZEG00005015427.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111202"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000285">
        <property type="entry name" value="Zinc finger matrin-type protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000612">
        <property type="entry name" value="Zinc finger matrin-type protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052644">
        <property type="entry name" value="ZMAT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="334"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054392"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066226"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020561.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="450" mass="48305" checksum="D111FBD81EC795D1" modified="2019-02-13" version="1">MLKPPLSLFSLPQQPFQHMDSLHQLGPPPMAPAHPLGPPPIAPAQSIGPPTMAHGQSLGLPPINAPHTLRPPPITPPHTLGPPPMPPGQSLGPPPMAHTLGPPPVDHTQAIVPPTMDLTQQLGPPHMNPAQALVPPPVVAPTAGRFPLPPSPLSSPPAPGPDPSQMPPRPLGPALIPATVSSLICGPLPGQAAPTSEQPQDEGSSLGTEEQEDSLGLEELCKPLYCKLCNVTLNSAQQAQAHYQGKNHSKKLRNFYAGSQQPPAIRIPEAFETAGQTALSSGSSDSDAGRQALYKGAPRVILATENDYCKLCDASFSSPAVAQAHYQGKNHAKKLRLAEAQQNASTMESSNETTPRRNRKDGSEYRLVKNRRSPQVPASMPGPYYNPRPRQRIPRDLAMCVTPSGQFYCSMCNCGAEQETDFRQHLESKQHKAKVSELRYRHEMENLGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFT1</accession>
    <name>A0A3P9CFT1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protocadherin-15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005020721"/>
    <dbReference type="Ensembl" id="ENSMZET00005021403.1">
        <property type="protein sequence ID" value="ENSMZEP00005020721.1"/>
        <property type="gene ID" value="ENSMZEG00005015337.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156675"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0050957">
        <property type="term" value="P:equilibrioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050953">
        <property type="term" value="P:sensory perception of light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000015">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3430:FF:000001">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000047">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000048">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000050">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000055">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000057">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000070">
        <property type="entry name" value="protocadherin-15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041149">
        <property type="entry name" value="EC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030718">
        <property type="entry name" value="EC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056989">
        <property type="entry name" value="PCDH15_12th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF11">
        <property type="entry name" value="PROTOCADHERIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18432">
        <property type="entry name" value="ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23206">
        <property type="entry name" value="PCDH15_12th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018101635" description="Protocadherin-15" evidence="16">
        <location>
            <begin position="18"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1378"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="140"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="270"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="388"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="502"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="609"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="711"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="813"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="924"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1034"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1142"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1614"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1618"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1636"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1654"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1725" mass="190202" checksum="81DD38DA68BCD50A" modified="2019-02-13" version="1">LCVRAIIMLAIAAQVTCNQNTYKCKLSRSGPPATIVAIDEESPNGTLLVDNMHINGVAEGPDRTISLSLRDNNDRWVILDPSKQALYLNSTGRVLDRDPPSYIHSIVVQVQCTNELIGTVILHEVRIVVRDRNDNAPRFQQPRYYVAVNELTPVGTTIFSGFSGNNGATDIDDGPNGQIEYTIQYNPRDPVANRTFDIPLTLFGSVVLRERLNYEDITRYLVIIQANDRAPNPSDRRTATTTLTVDVLDGDDLGPMFLPCTLVGNTRDCSPITYKANVLELTEPSKVNPLNVTPPIQAVDQDRNIQPPSDRPGILYSILIGKPESYVEYFRLNRTTAELLLLKPIDREHYHRFDLVIKAEQDNGHPLPAFASLQIEVLDENNQAPYFLQPSYHGYISEASPVGTTIATSASLSVPLAIIALDNDVEETRDPQLQFSLDSYSHVFSVSATGIKRYLTLVQPVDRETQDSYTFTLVASDGVQESTAVTVAITVLDANDNTPTFPNVSYNVNLFIDMMPGEAVLQLSAFDSDAGQNGLITYRILAGHQGHFVIGNSSGIITVAPGVQLSVGQSYALTVEAMDNGPEPHRRSSITTVYIEVLPPNNQSPPRFPRQQYNLEISEAMRTGATLLNLQAVDRERDPITYKIQSGDIQGHFALQQNSGYLVLDKPLDRETLDYYTLVVTASDGHPEGTSTATVSIVVTDVNDNDPLFDTSLPVNLTVIEEQKHAYVGQVKATDPDLGANGQVHYRLVNHQGLFSINATGTITTAVPLDREVRRSHYYLTVEAWDGAENPRRSRLTLRVTVLDIDDNSPIFTQQTYNVNLPENSPKGTVILQLKATDADLNSNLTYRIRTEGSDQDITQLFHIDSRTGELSVLKVLDFEALSESEPTYTFTVEALDTKGNMPPGLASVTVRIMDMNDFSPVFSQSVYRGMVAPNAVKGTIVTTVMANDSDPAGTPAGLVRYKVDQEAYPYSASIFGVEEQTGRVVTRVNLNEEPNMKFSLVVVAYDHGEPVMKNTTLVEITVLQPSVIPVFTREEYRFLPVSEEAAVGTPVGVILASAVNQTIVYSIIEGNEGGVFALNETTGVIYTAKPLDYETNASYVLKVEADSMRVVSSNLRAPSKTNTAKVVIDVQDENDHAPEFTRPLYIGGVAEDSKTFTSVLQVQALDKDTGNYSSIIYRLIVPPPASKDTKDTKDGFIIEPYSGVVKTAIMYRNMRRSYFKFEVVATDNYGQGHSSKADIVVSVVNQLDMQVVVSNVPPTYVEKNKEKLLSILERYVQEQIPGAKVVVETIGPHRHGDGMEQEDYTKSDLMIYAIDPLTNRAVSRQELYKFLDGKLLDINKEFQPFLPPGGRILEIRTPEVVTSVKKAVQTVGYTEGALLALAVIIIICCVPAILIVIITYKQRQAECAKTARIQMALPTGKPGGGTANNLYEELGDNAIGGSLDESDRQRLISDFATRAIAVHRQCVANGGVLHNFPKSESNITFLSDENPLTIKNPIYHEDGTLSSPETLGRSQRRKDLLGNFSPSRKGGGHSWTLPSRLHRREMYDALRRQVVMDPVQWELELLKAKFKESKDAGLDSGFDRGLDSDVMGSPSLEPKLTVKEQARQFEQQALQEMRQRQNRDSRGSLSPDILLSNTEGPPSIIVTQSDGGTPPPSHKPTPPVLRRFGANLTGNQGSEDRLQVHLEFIPDPPSTPPPPPPHPQTSWFRGFGLCLQLSCLLQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGK2</accession>
    <name>A0A3P9CGK2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U4/U6 small nuclear ribonucleoprotein Prp3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_024660067.1">
        <property type="nucleotide sequence ID" value="XM_024804299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGK2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021277"/>
    <dbReference type="Ensembl" id="ENSMZET00005021979.1">
        <property type="protein sequence ID" value="ENSMZEP00005021277.1"/>
        <property type="gene ID" value="ENSMZEG00005015970.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468747"/>
    <dbReference type="CTD" id="9129"/>
    <dbReference type="GeneTree" id="ENSGT00390000011497"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PWI" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="703" mass="78918" checksum="B8602422D9CA4B02" modified="2019-02-13" version="1">MSLPKREVEELRPWVERTVKKVLGFSEPTVVTAALHCVGKGLDKRKTIDQLRPFLDDSAGGFVERLFEALEESRSTRGNKGSGEKNRKRELKDVFGEEADTGAARETPEPTDGTTAKRKRVPRFEEVEQPEVIPGPPSESPGMLTKIQIKQMMEAATKQIEERKKQLSFTAPAPATTSQLDGPPLSRLLGTAGAAAAGGGSSIAPYQAASFMNDAIEKARKAAELQARIQSQLAMKPGILGVLGNTGPQNFVALANLHAMGIAPPKVEPKEVNKPTPLILDEKGRTVDASGKEVELTHRMPTLKANIRAVKREQFRQQLKEKPGDDLESTSYFDQRVPVPPAQRARRTFKFHDQGRFEKIAQRIRTKAQLERLQNEIAQAAKKTGIQASTKLALIAPKKEIGEGQVPNIEWWDSFILPSNIDINSDTKFEALELFGVTSLVEHPAQMSPPVDTDKPVTLGVYLTKKEQKKLRRQTRREGQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQRKEKKVKKLKEDLTNGVHIAVYRIRNLQNPSKKFKVEANANQLYLTGTVVLHKDVNIVVVEGGPKSQKKFKRLMMHRIKWEEHNSKRDDPDGDDDTKRNNKCWLIWEGTAKERSYGEIKFKQCPTESMAREHFKKHGTEHYWDLALSQSVLETTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGW9</accession>
    <name>A0A3P9CGW9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIN2 (TERF1) interacting telomerase inhibitor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012771705.2">
        <property type="nucleotide sequence ID" value="XM_012916251.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGW9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021530"/>
    <dbReference type="Ensembl" id="ENSMZET00005022240.1">
        <property type="protein sequence ID" value="ENSMZEP00005021530.1"/>
        <property type="gene ID" value="ENSMZEG00005016167.1"/>
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    <dbReference type="CTD" id="54984"/>
    <dbReference type="GeneTree" id="ENSGT00450000040279"/>
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        <property type="component" value="LG15"/>
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        <property type="term" value="F:telomerase inhibitor activity"/>
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        <property type="entry name" value="G_patch_dom"/>
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        <property type="entry name" value="PINX1"/>
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    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
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        <property type="entry name" value="G-patch"/>
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        <property type="entry name" value="G_PATCH"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="93"/>
            <end position="117"/>
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            <begin position="149"/>
            <end position="191"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="374"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="214"/>
            <end position="224"/>
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        <location>
            <begin position="262"/>
            <end position="271"/>
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        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="374" mass="42182" checksum="F083CEF29F10142B" modified="2019-02-13" version="1">MTLRLARRKLKWSVDPRNSAWSNDDSKFGQKMLERMGWSKGKGLGRSEQGSTDHIKVKVKNDSYGLGANASCEDKWIAHQDDFNELLAQLNSCHGQNSSSETPPNEQKGFSLEEKSKTSKKRVHYMKFTKGKDLSSRSETDLNCIFGKRAKSAKVQDQESNSSDSQGEAEDGVNPDPSDQDPEAITKTVTSTLTMQEYFAQRMAQLKKARGAQNADTPETSNASEEVGLNHNSNDDTEEPKKKKKKKKKAAEEQCSTPAAVVDKEDQEKERSKKKRKMAESEEVVNENCSSTCSTECEELQTKKKKLKKHSEQSELLNGHEPAEDETLDLNTVQKKKKRRDEVDSVATEDGKEELVEKKSKKKKKRKHQEQGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CH91</accession>
    <name>A0A3P9CH91_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="15">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="15"/>
    <dbReference type="RefSeq" id="XP_004541955.1">
        <property type="nucleotide sequence ID" value="XM_004541898.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9CH91"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021512"/>
    <dbReference type="Ensembl" id="ENSMZET00005022222.1">
        <property type="protein sequence ID" value="ENSMZEP00005021512.1"/>
        <property type="gene ID" value="ENSMZEG00005016158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474727"/>
    <dbReference type="KEGG" id="mze:101474727"/>
    <dbReference type="CTD" id="640"/>
    <dbReference type="GeneTree" id="ENSGT00940000165962"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05067">
        <property type="entry name" value="PTKc_Lck_Blk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09933">
        <property type="entry name" value="SH2_Src_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000553">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000036">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="17">
        <location>
            <begin position="108"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="226"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="489" mass="55873" checksum="FDE131CDB06C232F" modified="2019-02-13" version="1">MGCTCSGEKQEKEEGFRKGKHKSHASPSSNHIGRSGNAYTNNDDTIFIAQHDFKATNDSDLPFRKGDKLKVLQETGEWWLARLLTTGQEGLIPSNYVARADTLEVEKWFFKDLGRRETERLLLAPGNKPGSFLIRESETCKGSFSLSVKDYEGERGDVVKHYKIRCLDKGGYYISPSNTFPTLQELVQYYTHTADGLCQRLYAPCKPMAPQQPWAHDEWEIPRETVKMVKKLGAGQFGEVWMGYYKNTQKVAIKTLKEGTMAPEAFLQEANLMKQLRHDRLVRLHAVVTKEPILIVTEFMINGCLLDFLKTDEGKKLKLNKLIDMSAQIAEGMAYIEKKNYIHRDLRAANILVSETLHCKIADFGLARIIESEYTAQEGAKFPIKWTAPEAINFGTFSIKSDVWSFGILLTEIVTYGRIPYPGMTNPEVIRSLDRSYRMPCPDGCPEELYDIMMVCWKQKPDDRPTFEYLQNTLNDFFIATEGQYEMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJ19</accession>
    <name>A0A3P9CJ19_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Acylglycerol kinase, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.1.107</ecNumber>
            <ecNumber evidence="22">2.7.1.138</ecNumber>
            <ecNumber evidence="23">2.7.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Multiple substrate lipid kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:34071"/>
            <dbReference type="ChEBI" id="CHEBI:74938"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:43329"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41079"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:75757"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41080"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:75542"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43316"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:78209"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:43317"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N-(hexanoyl)sphing-4-enine + ATP = N-hexanoylsphing-4-enine 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43312"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63867"/>
            <dbReference type="ChEBI" id="CHEBI:82959"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:43313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33747"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33748"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a 2-acylglycerol + ATP = a 2-acyl-sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:64982"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:39848"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>a monoacylglycerol + ATP = a monoacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19293"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:77589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:19294"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17929"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57674"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.138"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:17930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the AGK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="5"/>
    <dbReference type="EC" id="2.7.1.138" evidence="22"/>
    <dbReference type="EC" id="2.7.1.94" evidence="23"/>
    <dbReference type="RefSeq" id="XP_004568301.1">
        <property type="nucleotide sequence ID" value="XM_004568244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJ19"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022285"/>
    <dbReference type="Ensembl" id="ENSMZET00005023028.1">
        <property type="protein sequence ID" value="ENSMZEP00005022285.1"/>
        <property type="gene ID" value="ENSMZEG00005016698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476009"/>
    <dbReference type="KEGG" id="mze:101476009"/>
    <dbReference type="CTD" id="55750"/>
    <dbReference type="GeneTree" id="ENSGT00940000154961"/>
    <dbReference type="OrthoDB" id="9979394at2759"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047620">
        <property type="term" value="F:acylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045579">
        <property type="entry name" value="AGK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19712">
        <property type="entry name" value="AGK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="30">
        <location>
            <begin position="61"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00025749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00026096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00026098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00026142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00044480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="423" mass="47827" checksum="D656F28E7D617C2C" modified="2019-02-13" version="1">MARVVKVFRTLRNHWKKSTFAVCVLSYGGYWLYGKHCDSVLRREACLLAREYGQQQIAPQERIRKATVILNPAACNGKANNLFEKNAAPILHLAGVQITVVKTDYEGQAKKLIELMEETDMLIVAGGDGTLQEVITGLLRRPDQDVFSKTPIGFIPLGSHNSLSPSLHLLSDNKVKDITSAALSILKGETVPLDVLQIKGEKEQPVFALMGLRWGAFRDVASKISKYWYLGPLKTNAAHWFSTLREWPLVRDVSVSYLAPTLRPPDLPPVKAPRPNLIHRIIHRLKNYWNPPAEELPKVEEPEKWEEQQLSTLELFIQTHNKNPVERRINDSLRISAEPHNLTVGEFITAGNKKAADPTVFTENATELEAGACWLQLPEGASGFYNIDNEEYEAMPVEVRLLPRKLRFFISAERREQLLSQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLC0</accession>
    <name>A0A3P9CLC0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLC0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022839"/>
    <dbReference type="Ensembl" id="ENSMZET00005023591.1">
        <property type="protein sequence ID" value="ENSMZEP00005022839.1"/>
        <property type="gene ID" value="ENSMZEG00005017101.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286903"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000047">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="111" mass="12775" checksum="A96056F58CB11686" modified="2019-02-13" version="1">MARTKQTARKSTRGKAPWKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQHLVREIAQDFNTDLRFQMAPLAFAYTAYATVRLCCVLRIQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLF4</accession>
    <name>A0A3P9CLF4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Si:ch211-225b11.4</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005023155"/>
    <dbReference type="Ensembl" id="ENSMZET00005023916.1">
        <property type="protein sequence ID" value="ENSMZEP00005023155.1"/>
        <property type="gene ID" value="ENSMZEG00005017340.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165952"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="5">
        <location>
            <begin position="515"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="4">
        <location>
            <begin position="920"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="6">
        <location>
            <begin position="1188"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1843" mass="205149" checksum="DFECE8C65CB6F3D6" modified="2019-02-13" version="1">MMLGFEELLRSLQDCVISENEAAENVSRTLRQFLQKLSESSRSGVKRCKERCLEEAVQLLRQLSEAQLSGLENDHLTLLVRLLISTQLQMVGISTACRKVDQMLQHLAKVDHQLVFRETRECFHSVVHSDQILCFEDLQRACMFLEDSTVGREVWRESYMSMLNKVSELLPVALQQESLRDGPLCYITVKVCLQIFQLLSSDVAPLVWDEEQRAPVQKILQTLMAIILGQCCNRDTRLLAGTAVAMLINTASENGAGGAAAWSLLQVSHLEPWLLAVGVLRVQCNPAEKDGVARLAVCRGLLTCCRPHILLSSHEDAPENRLLLHGLFPLVFTLCEEKLDCHYFAFELLNLWLKKVKEYLADLWKVTCVRLLPDNCTLLQQLIHLIWTNAESPVDGVSETARSAFFLLLDLYEMDCKQFCDTKRALYLTLLERIMKLPWEAKAKYHRLCALLPYLGTDKLLDQCPEISSHLLKCLSTNHLAPCGSELYKSLIQQQRRELCDGSSSHAELDLASHWARRWQSVLHEALTSEVPLLQNNSATQLLPCTFQVFPSAVDHMLASLDPYTPGHLHAWACILSSYRAVTGDSLWALQGSSTLETLQLALGSADDKVRLAALNLLCCCPKTKDTPTPQEMAIMRTFIPQNLNCDSSPFRQHFQAGVKKFLIRIRDGCLAYVRGQKGKKKGESSHSERTQDLLDQGIGFVEWLSQLPYTYLAPGHSYQRKKTALLLLSAVLETCTDTWSPDRKKGQPPANISSLISCARQRGQWDFFCRTKQLVLLSCLEDSTNEIRELAAGLLLRFFPPSFLDDLTEVLHTRTKQLLCSPRVQEAQMGALMMKILLQKSKHQCEGCRLNSRESNSKAFCMVKVLVKELEEHYLTAKADMMLAAREKPIHGALSALQRCLLETPNSVYDTLDPSLNMEVLGLLENISLLLLGVLYGDPEACASEKDAPPSFCDMGNAISSLIAQTSAGGQAEGEECVLLSEEHSLVLTCCWVSLKEIGIFLGSLVEKILTQSKPSKCLLTKQDLIKAAEIFKNILLKCRHWGAVEGCCIGFTKFCASLLSSSDPELRDIPAQMLKKGLQVVQCLRSTSVTRRAAGLPMLILCILSAEEASKARPLLAHSMQTLLETARTPLNDDWDQTLDLPQVCAVHTLQALVRSTALGAAILQFASDVAILSLTLLSSPCWAMRNAALQLYSSLCTRMLGQRSTSEEAGPTQHAMSPAAFFFHYPALQPFLLGELRGSAQDLEGPPNEAKLHLKPSLYPVLTLLAQLQPGVQDSEETLSDFLPPLLQLSASPIYSVRMMASKALVAMTPPSEYMNILINLTSQLPSPQQQCSHNRLHGQLLQIKAILERALCGNSTPSDNLFEVLSRIIASLWMVTEAQRCPLVRAVYLDVVDALRRFCCETYLSDLSSTLLRHLQTPQQSLQVGMSSFHEKAIHFLCADQQWACKIWENFSSASPDLRLTLVAWVLDGQSLRQTGLKEVVQRVLQANLREALLSRSVEYCRSYLAALVAVMARGDTASSQRVVLLAPLEEPVLLECLDLLLRDLEDQRGGPEFLSQAFSAASLLLSHWPQSSLKISMIQRWCGILECLWAPEVPEVLRIACAEALCVAGAPLMSHTMKEYSTLVPIMIRLINTGLYLLQDQSQEVRIKAACFASVLHHARRGQSQRNVYLVQVNQALPFLLDVLLEECWDAPGTLEVLMCHLPQSDLRSVLRHASVEGCSSLYEQDEANVFAEPSVMSVHVLPYLLQMAEKYSQSSSLARSLNSWAQDNAAQVVDGLAVCKEVQPAESLTPLWLALLVDPRFHSTLCGLLTRAAFLLRLLKTSNSAVAGELPLRQSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLM6</accession>
    <name>A0A3P9CLM6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Insulin-like growth factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Binds equally well IGF1 and IGF2. Interacts with integrin ITGA5:ITGB1. Interacts with VHL; this interaction inhibits HIF1A degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLM6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022939"/>
    <dbReference type="Ensembl" id="ENSMZET00005023692.1">
        <property type="protein sequence ID" value="ENSMZEP00005022939.1"/>
        <property type="gene ID" value="ENSMZEG00005017173.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157394"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031994">
        <property type="term" value="F:insulin-like growth factor I binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031995">
        <property type="term" value="F:insulin-like growth factor II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048640">
        <property type="term" value="P:negative regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031099">
        <property type="term" value="P:regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043567">
        <property type="term" value="P:regulation of insulin-like growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.40.20:FF:000001">
        <property type="entry name" value="Insulin-like growth factor binding protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000002">
        <property type="entry name" value="Insulin-like growth factor-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022322">
        <property type="entry name" value="IGFBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022321">
        <property type="entry name" value="IGFBP_1-6_chordata"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017891">
        <property type="entry name" value="Insulin_GF-bd_Cys-rich_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11551">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11551:SF6">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01976">
        <property type="entry name" value="IGFBPFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01977">
        <property type="entry name" value="IGFBPFAMILY1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00222">
        <property type="entry name" value="IGFBP_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="6" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018038307" description="Insulin-like growth factor-binding protein 1" evidence="13">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="15">
        <location>
            <begin position="34"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="14">
        <location>
            <begin position="185"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="264" mass="28068" checksum="6474EFF792202087" modified="2019-02-13" version="1">MLAVAGLYVGHVVTAALCSVLLTGTLGSPVVGPEPIRCAPCTPEKLSQCPAVAPGCAEVLREPGCGCCLACALKAGELCGIYTAPCGSGLRCVPRPGDPRPLHSLTRGQAVCTESPVPEPTPEPQTQDQEEPEPLEMDNAAIISDPGYSHYLPGHGRPYDPRAAADAQESMKAKLIAIRKKLIEQGPCHLELQTALEKIAKSQQKLGDKLTRFYLPNCDKNGLYKPKQCESSLDGQRGRCWCVNSWNGKRILGSTELPAGAECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMA1</accession>
    <name>A0A3P9CMA1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:23445"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:23446"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="12"/>
    <dbReference type="RefSeq" id="XP_004563446.1">
        <property type="nucleotide sequence ID" value="XM_004563389.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMA1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023455"/>
    <dbReference type="Ensembl" id="ENSMZET00005024227.1">
        <property type="protein sequence ID" value="ENSMZEP00005023455.1"/>
        <property type="gene ID" value="ENSMZEG00005017554.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474340"/>
    <dbReference type="KEGG" id="mze:101474340"/>
    <dbReference type="CTD" id="3939"/>
    <dbReference type="GeneTree" id="ENSGT00940000153201"/>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000029">
        <property type="entry name" value="L-lactate dehydrogenase A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000003">
        <property type="entry name" value="L-lactate dehydrogenase A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF10">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE A CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="163"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="332" mass="36306" checksum="D34F2241B8F40853" modified="2019-02-13" version="1">MSTMEKLIGHVMKEEPVGSRCKVTVVGVGMVGMATAVSILLKDLCDELALVDVMEDKLKGEAMDLQHGSLFLKTHKIVADKDYSVTANSKVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCILMVVSNPVDILTYVAWKLSGFPRHRVIGSGTNLDSARFRHIMGEKLHLHPSSCHGWIIGEHGDSSVPVWSGVNVAGVSLQGLNPKMGAEGDPEDWKAVHKMVVDGAYEVIKLKGYTSWAIGMSVADLVESIMKNLHKVHPVSTLVQGMHGVKEEVFLSIPCILGNSGLTDVIHMTLKPEEEKQLVKSAETLWGVQKELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CP85</accession>
    <name>A0A3P9CP85_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle associated membrane protein 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550843.1">
        <property type="nucleotide sequence ID" value="XM_004550786.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CP85"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023601"/>
    <dbReference type="Ensembl" id="ENSMZET00005024375.1">
        <property type="protein sequence ID" value="ENSMZEP00005023601.1"/>
        <property type="gene ID" value="ENSMZEG00005017659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477171"/>
    <dbReference type="KEGG" id="mze:101477171"/>
    <dbReference type="GeneTree" id="ENSGT00940000164382"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000013">
        <property type="entry name" value="Vesicle-associated membrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="125" mass="13324" checksum="126073BFCBAF764A" modified="2019-02-13" version="1">MSAPDAAPPAGAPGAPGAPGADGAPAGAPPGPPNTSSNRRLQQTQAQVEEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFESCAAKLKNKYWWKNCKMMIMMGIIGVIVVGIIFLYFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPX2</accession>
    <name>A0A3P9CPX2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein NLRC3-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPX2"/>
    <dbReference type="Ensembl" id="ENSMZET00005025195.1">
        <property type="protein sequence ID" value="ENSMZEP00005024395.1"/>
        <property type="gene ID" value="ENSMZEG00005018232.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286911"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16040">
        <property type="entry name" value="SPRY_PRY_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000210">
        <property type="entry name" value="Si:dkey-16p6.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029495">
        <property type="entry name" value="NACHT-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14484">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01288">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="145"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="767"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="956" mass="109045" checksum="9217AF45E64CC66A" modified="2019-02-13" version="1">MKNPVQLSCEHWCCKLCLSSDLDESVSPADCPCPQCGKKSKKTLKQEKDKEGDTGKIHLLEAKKKLKEAMKEKYSSVSEGNGDKPSSLNNIYTELHITTGESERSREEHEVRLLEHKRIRHTSEQQIINLNDVLKPLPDQDKPHRTVVTKGVAGIGKSFSVQKFILDWAEEKANQDLDFVFSLAFRELNLITGEKSLHELLTLFHPTLSELKDSVDYTKTKTVLILDGLDESRFQLDFEGFKTITSVKEVTPVSNLLANIIQGNLLPDANLWITSRPAAANQIPAEHVDMVTEIRGFNDPQKAEYFRRRFNHDPDLADRIIKHIQSSQSLDSMCQIPIFCWISAVLFQEVFGGDVETAIPQTLTEMMSHFLFAQTKRRNRKYDKKVETNKEKLLKTQRKFLLKLGKLAFEQLLKNNLIFYEEDLEDFGIDIKEASMYSGFCTTVLREEEIISQKKVFFFVHLTLQEFFAALHIYDCFINNDTTELSSFLDLKSQEHTLLDLLKMMVDKVLEKKNGHLDFFLRFLLGLLVEPNRRVLHGLLPSPDQSQDTEKKILTYLKSMRRKNLSPDSCINLFQTMVEMRGHKVKDEIQEYLALSDRSKTELTPLHCSALAYMLQVSKNDLEVLDLKSYNTSEEGRRRLIPAVRSSGKALLADCKVTEEWVEHLAFGLTFPFSPLRHLDLSNNDLKDSGVELLCKGLSNQCCRLKTLRLSGCLVTEKGCGFLATSIKANPSHLKELDLSYNHPGGVGKKKLSELKDDPKYNLSQLNFEHGGHHRMKPGFKKYACELSLNSSTAHKNLLLSEDKRKVTWVEEEQAYPDHTERFDCCQQVLCKQGLKGRCYFELEVSEPFCVGLTYRNIGRKGDVDACKLGQNNKSWCLICSDDGCFVQHNKEKVCVSSQCLRSSRVGVYLDSEDKILSFYRISSGSLVHLHTFKSTFTDVLYPAVALHTHSSALFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQ35</accession>
    <name>A0A3P9CQ35_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Si:dkeyp-77h1.4</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004550916.1">
        <property type="nucleotide sequence ID" value="XM_004550859.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQ35"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024460"/>
    <dbReference type="Ensembl" id="ENSMZET00005025262.1">
        <property type="protein sequence ID" value="ENSMZEP00005024460.1"/>
        <property type="gene ID" value="ENSMZEG00005018283.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470305"/>
    <dbReference type="KEGG" id="mze:101470305"/>
    <dbReference type="GeneTree" id="ENSGT00390000005284"/>
    <dbReference type="OrthoDB" id="8871625at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF13">
        <property type="entry name" value="SI:DKEYP-77H1.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="646" mass="69875" checksum="905556FEB48CC321" modified="2019-02-13" version="1">MHRSSSRPLKDAKESTIMGTFRVIVLSLLVTTALSAPLKADEESYTLFHGEDFHILLPSQNVEVTFHNKSAPRSKDVHLMREGKVVHSRPKLDRSNTHLLIEAVGEGDEGVYTVKNLEKPDDVKRMSLTVRDCTVEQMVKYGDKFSIHLSRVNPPITLEYRPRATEARETFRPGLVVLTAAGTSPERYQGRVSTGGPYVTLSGVTDADEGSYTVRDNKGGIERKVCLNVKEHKEFVKLQRGNKLKINLILNSSLVYLYYSPKSDSTLRLLLDKGEFTPAQTELGFENRLSLEGSLVILDDVNDKDEGLFTIKDLQNFTVSTVFLEMKPYKLETLYVAIIALLGLLAFLLLVCLLSCLIKVKKRAKRAAALEKIAQNAGKEEEGEAFRQVVKNITKMSEESKHSQADNTEKSQSTEVDIKGLEVSSKEVGVGNLETSDSGVGFNTALPLDTDTEAPDQIPDSEAVSISIAPETKPSPPPAAESKPSAPPAVEIKPSPVPETKVTPAPETKKTPDKPVEEKLDVPKGAAVKPSPAPSPEPKADKKPAPSPSPEPKPAVPKATTPTPDSKSALTPTPEHPKPTTPEPITNGTPEPGPDSKLSPDHADIIKGSAPKAVAPKTPEVELKASGAILEAGKDGTVAEDSTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQU8</accession>
    <name>A0A3P9CQU8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 5 member 9</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQU8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024181"/>
    <dbReference type="Ensembl" id="ENSMZET00005024974.1">
        <property type="protein sequence ID" value="ENSMZEP00005024181.1"/>
        <property type="gene ID" value="ENSMZEG00005018087.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157546"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005412">
        <property type="term" value="F:D-glucose:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000004">
        <property type="entry name" value="sodium/glucose cotransporter 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819:SF96">
        <property type="entry name" value="SODIUM_GLUCOSE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11819">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="589" mass="64411" checksum="D1D3BF4EB8A1485F" modified="2019-02-13" version="1">SVPLQIGASLMSSNVGSGLFIGLAGTGAAGGIAVGGFEWNASWVLVALGWIFIPVYISAEVVTMPEYLAKRFGGQRIRIYMSVLSLILYIFTKISTDIFSGALFIQVSFGWNLYLSTVILLLVTAVYTVAGGLAAVIYTDALQTLIMVGGAFALMFIAFSKVGWYEGLMDRYMSSIPNVTVPNTTCHLPRSDAFHMFRDPVTGDLPWPGLLFGLTVLATWVWCTDQVIVQRSLSAKSLSHAKAGSVLGGYLKLLPMFFVVMPGMISQALFPNEVGCVDPDICQSVCGASVGCSNIAYPKLVIELMPVGLRGLMLAVMLAALMSSLTSIFNSSSTLFTLDLYHKARPKASELELMIVGRVFILVLVCLSLLWIPVVQTANSGQLFDYIQSVTSFLAPPITALFLMAIFWPRANEQGAFWGLMAGLVIGLIRMVLEFSYSPPSCGQPDHRPAVLADVHYLYFALILLALTCLIIVAVSLATAPIPKENLHRLTWWSRHSLERRMDLSSLQITSDQVDSNLSSESDRLQESTWKKVVLWLCGLSSSRSESAAPVIQSSERNFLQEKSLWRIVCDVNALLLLVVNVFLWGYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CWX9</accession>
    <name>A0A3P9CWX9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kelch-like family member 40b</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">A band</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
            <location evidence="2">I band</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KLHL40 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546797.1">
        <property type="nucleotide sequence ID" value="XM_004546740.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CWX9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026497"/>
    <dbReference type="Ensembl" id="ENSMZET00005027354.1">
        <property type="protein sequence ID" value="ENSMZEP00005026497.1"/>
        <property type="gene ID" value="ENSMZEG00005019769.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472315"/>
    <dbReference type="KEGG" id="mze:101472315"/>
    <dbReference type="CTD" id="795319"/>
    <dbReference type="GeneTree" id="ENSGT00940000156360"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031672">
        <property type="term" value="C:A band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036268">
        <property type="term" value="P:swimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18340">
        <property type="entry name" value="BTB_POZ_KLHL40_KBTBD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000006">
        <property type="entry name" value="Kelch repeat and BTB domain-containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000037">
        <property type="entry name" value="Kelch-like family member 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030607">
        <property type="entry name" value="KLHL40_BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF22">
        <property type="entry name" value="KELCH-LIKE PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="10">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="615" mass="69704" checksum="0B0903F20EFC485C" modified="2019-02-13" version="1">MALPINPADEPRLYQQTLLQDGLYDLLENDKLVDCVLKIKDKEFPCHRLVLCACSSYFRSIFLSDLDESKKREIILEDVEPGVMGLIVKYLYTSKINVTEQNVQDIFAVANMYQIPSIFTVCVSFLQKRLSLSNCLAIFRLGLMLDCPRLAISARNYACERFQLISRDEEFLQLLPSELAAILSNDNLNVETEEEVFEALMNWVSRNKETREKELPNLLDCIRLRLVNEDYLREKVEKHKLISSNPELQQKLQLVKDAHAGKMPEVKKRKSKEEEDGGAGNDGESEDKDDEEGLLPSILNDNLRFGMFVRDLILMVNDAGAVAYDPTGNDCFLASLSTQIPKNHASLVTKENQIFVAGGLFFDEQNKDDPLCSYFLQYDPVSADWLGMPPLPSPRFLFGMGEAENSIFVLGGKELKEQEHMLDSVLVYDRQSFKWGESEPIPYPVYGHTTLSHNDTVYVIGGKGDNKSCLKKMCAYDAKRFEWKELAPMKHARSLCGATVHENKIYVAGGVTDNGLTDTMEVYDIATNKWSDFVPFPQERSSLNLVSLAGSLYAVGGFAMMPLEDSEEVLPKEMNDIWRYNEMEKKWNGILKEIKYASGASVLGVRLNTLRLTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZ65</accession>
    <name>A0A3P9CZ65_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Lipase member H</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40943"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64839"/>
            <dbReference type="ChEBI" id="CHEBI:77593"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:40944"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024659419.1">
        <property type="nucleotide sequence ID" value="XM_024803651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZ65"/>
    <dbReference type="Ensembl" id="ENSMZET00005028507.1">
        <property type="protein sequence ID" value="ENSMZEP00005027628.1"/>
        <property type="gene ID" value="ENSMZEG00005020610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473516"/>
    <dbReference type="KEGG" id="mze:101473516"/>
    <dbReference type="CTD" id="100003046"/>
    <dbReference type="GeneTree" id="ENSGT00940000166938"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000063">
        <property type="entry name" value="Lipase member H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF12">
        <property type="entry name" value="LIPASE MEMBER H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018169711" evidence="18">
        <location>
            <begin position="22"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="19">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="459" mass="51827" checksum="5B104C2FC46865F3" modified="2019-02-13" version="1">MRRMLSRKLLALLGLLVLCKGQEESEAGESCDNFTDLDLTHCFVGTTLYVRLLLYTRSNLDCGRELNHHHLSSQPLFSLSRPTAFVIHGYRPTGAPPIWINHIVHLLAEQEDMNIIVVDWNKGAANLNYFTAVSYTREAALNLTGFIMTMEAEGASLSSVHLIGVSLGAHLAGFVGANLKGKIGRITGLDPAGPMFTRATPEERLDPSDAMFVDVLHTDMNSFGLRGAHGHIDFYANGGADQPGCPKTIFSGKSYFVCDHQRSVFLFLCALNRTCTLTGYPCSSYSDFLDARCLQCETFKPASCPILGYDVSPWRETLQQLGQTKVFFSTTDALPYKKLMYRVDMVTWNQYLRWGVVYIRLHSGRNVTEARIDHKLLRFEQYTSTRLLAQFDEDLQHIQKISLRINTGNVIGPRYKIRLLRVRFTPLELPERPLMCRFDIIMEENIEVAFRPLPCGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZI3</accession>
    <name>A0A3P9CZI3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Neuropeptide FF receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">G-protein coupled receptor 74</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555690.1">
        <property type="nucleotide sequence ID" value="XM_004555633.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZI3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027743"/>
    <dbReference type="Ensembl" id="ENSMZET00005028623.1">
        <property type="protein sequence ID" value="ENSMZEP00005027743.1"/>
        <property type="gene ID" value="ENSMZEG00005020684.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484523"/>
    <dbReference type="KEGG" id="mze:101484523"/>
    <dbReference type="CTD" id="560955"/>
    <dbReference type="GeneTree" id="ENSGT01150000286926"/>
    <dbReference type="OrthoDB" id="5953793at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031628">
        <property type="term" value="F:opioid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043408">
        <property type="term" value="P:regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15980">
        <property type="entry name" value="7tmA_NPFFR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000137">
        <property type="entry name" value="neuropeptide FF receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005395">
        <property type="entry name" value="NPFF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005397">
        <property type="entry name" value="NPFF_rcpt_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF132">
        <property type="entry name" value="NEUROPEPTIDE FF RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01570">
        <property type="entry name" value="NPFFRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01572">
        <property type="entry name" value="NPFFRECEPTR2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="62"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="426" mass="48239" checksum="0ACFA009E36607A6" modified="2019-02-13" version="1">MNEGFENNLTQLNDNWTLYNSSLESVIPRSNITYVGFYLHQPSTAAIFIVSYLLIFLVCMVGNGVVCFIVLRSKNMRTVTNLFILNLAVSDLLVGIFCMPTTLLDNIITGWPFGSLVCKMSGMVQGISVSASVFTLVAIAVDRFRCIVYPFKQKLTISTATLIIVIIWVLAVSIMCPSGVMLQVTKEQTIRVLLGYDNKTIPFYWCRENWPNQDMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAVPTGGKPGHENRHTVSKKKQRVIKMLLIVALLFILSWLPLWTLMMLSDYARLTEQQYRIINIYIYPFAHWLAFFNSSVNPIIYGFFNENFRRGFQAVFKFSLCTADGQRRKTYSHRLQGNSVLPANNAQTCLEPISLNSLEKNTSRRINHVTEQDLVMEDLEKASCSSGGVTAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D0D4</accession>
    <name>A0A3P9D0D4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell death inducing DFFA like effector b</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005028105"/>
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        <property type="protein sequence ID" value="ENSMZEP00005028105.1"/>
        <property type="gene ID" value="ENSMZEG00005020973.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018596"/>
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        <property type="component" value="LG3"/>
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        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CELL DEATH ACTIVATOR CIDE"/>
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        <property type="entry name" value="LIPID TRANSFERASE CIDEB"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="222" mass="24961" checksum="F7D84E2039F6B086" modified="2019-02-13" version="1">MNQSQNRSIIFKPFFVSSVLRSVTKRVWSPTQRPFRVCCHNRNTRKGVTAGTLEELKERVCQALLLSLSAVSLSLVCEDDGTEVDSDEFLMTLPDNVMLMALEPGQTWRSQQGAVVPKAQDHNKSRTGRDIARVTFDLYRMSPKDVFGSLNVQATFQGLYSVSADFQCLGPKKVLREVLRVASTLLQAAGHLLLTSATMIRRIIEGAELWQPQRAEYAARWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1G3</accession>
    <name>A0A3P9D1G3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MLLT10 histone lysine methyltransferase DOT1L cofactor</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_024654667.1">
        <property type="nucleotide sequence ID" value="XM_024798899.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9D1G3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028433"/>
    <dbReference type="Ensembl" id="ENSMZET00005029337.1">
        <property type="protein sequence ID" value="ENSMZEP00005028433.1"/>
        <property type="gene ID" value="ENSMZEG00005021201.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157711"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:nucleosome binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CC_AF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15708">
        <property type="entry name" value="ePHD_AF10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="protein AF-10 isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="protein AF-10 isoform X2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EPHD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF93">
        <property type="entry name" value="PROTEIN AF-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="80"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="135"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="462"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="593"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="701"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="847"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="802"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1094" mass="112195" checksum="C2025954DF4EF6D9" modified="2019-02-13" version="1">MVSGERCLAADDEFLTSNMKEMIGGCCVCSDERGWAENPLVYCDGHGCNVAVHQACYGIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVEFANVSTMEPIVLQSVPHERYNKTCYICEDQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEQGSDADNVKYCGYCKYHHSKLRRSRGRGSRSQSLSDSSTQCMDRPPDTDKKKHKERDRHKPKHKKTSMDMSPSLILPNIMVPEKTYNSGNSGGGVSSLQASSQKRLDDSAARFTNANFQEVSSAHSGSSSKDALAADSVKAATEVKNKKNSGGGHTVGPRGGRKSLTSSGKPLPSAVVTMATSSTSASASTGPFHQGLLLTSASKTPSAASSSDFLSFTDSSLRPGGGSTFSSPPSFSSCLVKPGSEGGASEGTTTLFGSLMSATTASAVGGKLYENSHSHTVSETTSLVGSTGYKRPQPSSSGLGISGAAAGGGEDGVKKKKKGNWRNRFGPCFTTDVKPSEPAPSLTLPTTSTANTTSSSTASPSSSSSSTLSGRPCLVSSSGLGVGVGGGSGGGERGLGVMGVSGGIQKSPSLLRNGSLQSNSSSTTTGSGVFSVADGSSSGTGAVTMGGANSELSQQQQPTPSLAPPSPFTATAPLNSTASTHVSALPGSVFNLAPPHMFGNRLNPNSTMAALIAQSEASPADQEAGDGSNSGGGCVGAQGFSIRASPKTTPRSPIGGLQIRYDSSGSLPGPGQGLLGAGGGGETLPPVATSIEQLLERQWNEGQSFLLQQGAQGDVVSMLKSLHQLQEENRRLEEQIKTLTMKKERLQLLSAQLSVPFTPATASSDVKGAQPGAADSSLPVATQDSASCGGHSSSGSTSSLSTPPSVSQSPPQPQLNGVASVGVTPAGLGGVAGLMGALGAGSALGMGGIVGALNGVIQTPAGTSSPHTHTTGAATGVTLPVNNNATRIGLLSEQQRLLLQQHQLHQLLSSQPSVEQQQVLLYQLMQQQDLQQLQSLSSSAQIPSIPLSSAQLPINNLLPGAQSQGQGTITANPFLALQHAHADTHGSGAQKPRLAEKAVGVGGQEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2Z4</accession>
    <name>A0A3P9D2Z4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain 34Bb</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKRD34 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D2Z4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028476"/>
    <dbReference type="Ensembl" id="ENSMZET00005029380.1">
        <property type="protein sequence ID" value="ENSMZEP00005028476.1"/>
        <property type="gene ID" value="ENSMZEG00005021235.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012355"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042637">
        <property type="entry name" value="AN34A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156:SF1">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="558" mass="60730" checksum="E12013C722BC16AD" modified="2019-02-13" version="1">MDESTEVRTDGNSLLKAVYLCRLRLTRLLLEGGAYINESNEHGETPLMVACKTCYTDSQSVPQHKMVYLLENGADPNIQDKTGKTALMHACLQQMGAEILSLLLNSGADPTLEDHGGLSALVYAVNSGNRDILSVLLDACKAKGKEVIIITTNKLPSGHQVTKQYLNVPPSPEVEESLHYLPASCCMSPYEVQLRTPPQGSSAKTSPQPGSPLRALKDPQCLGLGHGLIRFQPGSPMQHRSPLRVPDVDKRPNFHQLHSEAWSKSPSLLLQQSQASSLTEEPVEITPEEVLSFRVEEHPPAISRHQSIDFKDAKGLVKALEILSGNDNRGGGGKKGFGRKMSYDSAASSLYSVSHPNLLQDSLAFSHESRPADEDSSDCLTQMNVSSLQNVVRRRNIGIAHYSSDSQLQQFSSRDRTSKSSGGAGLAAERHKLVTSRASNLLGSRESLESSAQRRATTGLERRGSGALLLDHIAHTRPGYLPRLNPHIPIPDIGVSSNSSCPLSGSTKTLNGVLIGPKPVLPCVPVFPKDLKAKKMLWRRHSMQSDQIKQLANFAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D324</accession>
    <name>A0A3P9D324_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc-binding protein A33-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004566467.2">
        <property type="nucleotide sequence ID" value="XM_004566410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D324"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028983"/>
    <dbReference type="Ensembl" id="ENSMZET00005029901.1">
        <property type="protein sequence ID" value="ENSMZEP00005028983.1"/>
        <property type="gene ID" value="ENSMZEG00005021623.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101484012"/>
    <dbReference type="GeneTree" id="ENSGT00970000193381"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12893">
        <property type="entry name" value="SPRY_PRY_TRIM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="11">
        <location>
            <begin position="267"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="462" mass="52720" checksum="8903180739D6ACA9" modified="2019-02-13" version="1">MASKLQEDLSCPVCKDIFKDPVILSCKHSFCNDCLQKYWANKNDLGCPVCKRKSSKECPPVYFELKKRCEAFLQERASEPVCSLHSEKLSIFCVDEQLLLCRYCTDQEAHRNHRFQSVDEASQDHKKKLEDSLKPLKKKMRAIREVKGKCDQTAEHIRAQAESTARSIKEHFQKLHQFLEEEEAARLVALREEEEQKSQVMKEKIGALSREITALYRTIKDTENELRAGNVSFLQNYRAAVERVQQQPLPDDAELASGAQVDVAQHVGNLSFNVWVKMKEMVSYCPVILDPNTAHPGVILSEDLTSVRQGEQTQELPDNPERIDHFFSVVSSEGFDSGSHSWEVEVGDNTAFVLGVLTDSFQRKGVIWPALWRLMFCGGEYKILSPLDPGSDVQVTRNPKRIRLQLDFDRGELSFYDSDTDTHIHTFTHSFTDRLFPYISTWCDVPIKIVALKISVTVDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D354</accession>
    <name>A0A3P9D354_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004572797.1">
        <property type="nucleotide sequence ID" value="XM_004572740.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D354"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029050"/>
    <dbReference type="Ensembl" id="ENSMZET00005029968.1">
        <property type="protein sequence ID" value="ENSMZEP00005029050.1"/>
        <property type="gene ID" value="ENSMZEG00005021664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464687"/>
    <dbReference type="KEGG" id="mze:101464687"/>
    <dbReference type="CTD" id="440574"/>
    <dbReference type="GeneTree" id="ENSGT00940000168345"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="78" mass="8647" checksum="61C1FFBEF9F29367" modified="2019-02-13" version="1">MFSMSEKELGKKWDRCLADGAIKLGTGLGLGIVFSVLFFKRHTWPISLGSGAGLGMAYANCQNNLRSHYMLHRGDKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3K6</accession>
    <name>A0A3P9D3K6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division cycle 16 homolog (S. cerevisiae)</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3K6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028929"/>
    <dbReference type="Ensembl" id="ENSMZET00005029845.1">
        <property type="protein sequence ID" value="ENSMZEP00005028929.1"/>
        <property type="gene ID" value="ENSMZEG00005021583.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182950"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="498"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="637" mass="72617" checksum="7F51AED05833B714" modified="2019-02-13" version="1">MNLDRLRKRVRQYIDQQQYQSALFWADKIASLSHEDPQDIYWLAQCLYLTSQYHRASHALRSRKLDKLYGACQYLAARCHYAAKEFQQALDILDAEEPASKKLLDRSGKEDNETSESTKDWDMSPASISSSICLLRGKIYDAMDNRPLATSSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKEFLDSLPLSQQCTEEEEELLHFLFENKLKKYNKPSDLVVPEMVNGLQDNLDVVVSLAERHYYNCDFKMCYKLTSMVMVKDPFHASCLPVHIGTLVELGKANELFYLSHKLVDLYPNNPVSFFFSLFDLCLGLLWVATISWLLLTVYVLVSQTYLLLYISLSKATTLERTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVIHEVAVVAFQNGDWKTAEKLFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYDQALEYHRQALVLIPQHASTYAAIGYVHSLMGDFESAIDYFHTALGLKRDDTFSVTMLGHCIEMYIGDTDAYIGTDINDKVRGNLNTPALMKMLNTSEPDDLLATPRLEDTSIMSLETPIPNQDKMMLETPLRLSLTLECDMYESDVMLDTLSDTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4C3</accession>
    <name>A0A3P9D4C3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4C3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029199"/>
    <dbReference type="Ensembl" id="ENSMZET00005030117.1">
        <property type="protein sequence ID" value="ENSMZEP00005029199.1"/>
        <property type="gene ID" value="ENSMZEG00005021767.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163630"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="496"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="792" mass="90277" checksum="8D15A69D968F094F" modified="2019-02-13" version="1">MLRFVTWNVNGAGTRGKRLKIFNQLKKLQADVVLLQETHKPVTGLNELKTPEFPNAFAAGYNSRQRGVAILIHKNVNFTVLDTVIDPEGRFLIIKLSILNKKLCIVSIYGPNVDEPSFFHGFFSALSEHLDCTLILGGDLNLGLNEEMDRLNTTGTQRNWQSTNIIKQYMNDFGLCDAWRSLHPTSKEYTFFSHVHHSYSRLDYFLVSSSLLCDISDTEIHPIAVSDHAPVSLTLMHKNNTTPSKNWRFNISLLKDEDFIKYFKKEWTSYLDFNDTPGISASVLWEAGKAVMRGKIISFSSHKKKEENKNIQELEKNIKSLEEAYACDQDQETLNKICKTKLELNEIINKKTQFLIQRLRLQNFEHSNKSGRFLANQLKINKEKTTICAAKDLSGNTIYDPGRINNIFRDFYETLYSPQINPSKNEIDLFLDNVTLPKLLDSQAMELDSPLTPSELQEALISMPNNKAPGPDGFPAEFYKEFWTILAPVFHSMLQEIEENGRLPPNMNSANISLLLKPGKDPLFPSSYRPISLLNVDLKIICKALSKRLEKMTPLLIHPDQTGFIKGRHSSTNTRRLLNLIDYSYDKNIEAIILSLDAEKAFDRVNWKFLFATLHKFGFGNSFINWIRILYNSPTARIRTNDQTSSSFYLLRGTRQGCPLSPSLFAIFIEPLAAAFRQATTIKGIKCKNIEHKISLYADDVLLFLQNTQTNLSEVITLINWFSRVSDYSINWPKSTVLPINCSFHNSSSAPLQSGNIKYLGINVSPKLSDLTKLNHIPLLKKVEGDLTRWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D610</accession>
    <name>A0A3P9D610_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BCL2 interacting protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_024659015.1">
        <property type="nucleotide sequence ID" value="XM_024803247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D610"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030115"/>
    <dbReference type="Ensembl" id="ENSMZET00005031063.1">
        <property type="protein sequence ID" value="ENSMZEP00005030115.1"/>
        <property type="gene ID" value="ENSMZEG00005022453.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480492"/>
    <dbReference type="CTD" id="663"/>
    <dbReference type="GeneTree" id="ENSGT00940000158531"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000001">
        <property type="entry name" value="BCL2/adenovirus E1B protein-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022181">
        <property type="entry name" value="Bcl2-/adenovirus-E1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF12">
        <property type="entry name" value="BCL2_ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12496">
        <property type="entry name" value="BNIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="286"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="467" mass="52597" checksum="9BE6F40D0A06E7CE" modified="2019-02-13" version="1">MASDVIESEAVLKGVSNMNLNNSSPDTVTPRRTLEDLGNRQTSSPSSSGVSGEGDDEETDELQNSTASAAEKGEEEFQDSLTKTSGTPQERKTPDNVQKQRGKSSTPVSVPQPRSPAGATGSLERQESVATTEARLRMEGVELKEEWQDEDFPRPLPEEEELEDELFAEASEAGNSGYAVNHGKKTKKKLAAPDISLTLDRSEGSLLSDELDESTELDLSDMDTPSDNSNEFEWEDDLPKPKPTELLQKGVESVHEYSASEEREDSRRWKMLRIGDQEHRVDMKAIEPYKRVISHGGYYGDGLNAVIVFAVCFMPESNQPNYRYIMENLFKYVIGTLELLVAENYMIVYLNGATSRKKMPTVGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLALTKPFISSKFSQKIKYVYSLSDLADLVPMEYVSIPDCIKQFDEEKNRKSRKRIDQDMHGKTESAAATVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8K8</accession>
    <name>A0A3P9D8K8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8K8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030452"/>
    <dbReference type="Ensembl" id="ENSMZET00005031412.1">
        <property type="protein sequence ID" value="ENSMZEP00005030452.1"/>
        <property type="gene ID" value="ENSMZEG00005022688.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166448"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042078">
        <property type="term" value="P:germ-line stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655:SF2">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tudor" evidence="8">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="250" mass="28328" checksum="CB480C3D64199842" modified="2019-02-13" version="1">MVKISVLKVENPSCLWGAIWGLSGDVETSEHYKKLHFQMNLFYRDTTQDVCTLKPTSLEEGRVYVVYWAVKKSWFRAVVESIFVDSVSCQACCFLVDHGEKVVVPSEQIRLAMENFLQLPFWVQKFHLAGIKPTTLRVSLLEEKAELKPSARWDSSATLFLHKLLQASTLKEAVLLEPESDSTPIKLYVTVGDIKICVNDDLVAKRFAYYSTKSGDGLEEGDRLPINQQSVYIANVTTTQDNTTHQLCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D962</accession>
    <name>A0A3P9D962_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EIF3D</name>
        <name evidence="5" type="synonym">EIF3S7</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D962"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031240"/>
    <dbReference type="Ensembl" id="ENSMZET00005032251.1">
        <property type="protein sequence ID" value="ENSMZEP00005031240.1"/>
        <property type="gene ID" value="ENSMZEG00005023294.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474770"/>
    <dbReference type="KEGG" id="mze:101474770"/>
    <dbReference type="GeneTree" id="ENSGT00390000002667"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="552" mass="64232" checksum="484486038D8A60AC" modified="2019-02-13" version="1">MAKFHAPVIQDNPSGWGPCAVPEKFKDMPYQPFSKGDRLGKVADWTGATYQDKRYTNKYSSQFGGGSQYAYFHEEDETSFQLVDTAKTQKTAYQRNRMRFAQRNLRRDKDRRNMTQFNMQTLPKSAKQKERERMRLQKKFQKQFGVRQKWDQKSQAQLKPRDSSVEVRSDWEVKEEMDFPRLMKMRYMEVSDPLDIECCGALEYYDKAFDRITTRNEKQLKSIKRIFHTVTTTDDPVIRKLAKTQGNVFATDAILATLMCCTRSVNSWDIIVQRVGNKLFFDKRDNSDFDLLTVSETANEPPQDEGNSFNSPRNLAMEATYINHNFSQQCLRMGGDRYKFPNSNPFVEEDMDKSEVASVAYRYRHWKLGEDIDLIVRCEHDGVMTGASGEVSFINVKTLNEWDSRYCNGVDWRQKLDSQRGAVLATELKNNSYKLARWTCCAMLAGSEYLKLGYVSRYHVKDSARHVILGTQQFKPNEFASQINLSMENAWGILRCVIDICLKLDEGKYLILKDPNKQVIRVYSLPDGTFSSDEDEEEEEDEEDEEEEDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAV5</accession>
    <name>A0A3P9DAV5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tripartite motif containing 39</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="LG7"/>
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    <sequence length="555" mass="63754" checksum="E2DC9AB72E164A74" modified="2019-02-13" version="1">MHSIVLSLSGLQGGFSLSQLSFCNRQGTPWTGRQSIAGLTQRDKQPFTLTPMGNLELPIKLTPLTPCLWTVREQTDRQKDRGPMAEFNSGTSYTCKEYKPDTFFFSFFCELKKKCFFFFLRQSADMSAASSLRSEDQFLCSVCLDVFTDPVSIPCGHNFCKNCITEYWDINKRCQCPMCNETFNTRPHLRVNTFISEVTHLEPHLTKKGLKRHQLIDAVENLEGRMCKKYDKPLELFCKTDQTCVCARCSISDHKNHEFVPLKDEYEGKKAELEKTEAEIQQMIQKRRLKIQQIKESVKMSKGDADRQKAEGVQVFTALKKSVDRGLKELIKEIEDKQETKEKHAEGLIKDLEQEISELKKRRSELEETLRKLMKKKLFEAELKRVQQYAVDVTLDLDTANSKLILSDDEKQVHCGDVRKKLPDNPERFSPCPNVLGKQSFSSGRFYFEVQVKGKTAWTLGVARESINRKGKIPLCPQDGFWTVWLRNGNEYRALAGPPVPLCLQSGPEMIGVFVDYEEGLVSFYDVDFITNIITFILLFFYSHLSSLDSEPLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DBX2</accession>
    <name>A0A3P9DBX2_9CICH</name>
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        <submittedName>
            <fullName evidence="8">E3 ubiquitin/ISG15 ligase TRIM25-like</fullName>
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        <name type="common">zebra mbuna</name>
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        <scope>IDENTIFICATION</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="312" mass="35900" checksum="24CA26A5811D663C" modified="2019-02-13" version="1">MLAETSHHYCLDLLKDPVTIPCGHSYCMNCVKIYWDEEDQKETHSCPQCRQTFTPRPALVRNTVIADLVEETKKTGLQAAKADLCHAEHEDVSCDFCTETKLKAVKSCLQCLVSYCEQHLQPHYESSAFKKHKLVDPSQKLQEIMCPRHNEVMKIFCRTDQQCICYLCSMDEHKGHDTVSTAAEMSEKQTELKEREMDIERKIKEKEKSLKVLQQEISELRRRKAELEQLSHTEDPTQFLHNYTLLSCLSEAPDSASINIHPESYTEHVAAAVSETREKLQDNVEWTITAVEETQGDVLNCQRQSPRPELNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGS8</accession>
    <name>A0A3P9DGS8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chemokine interleukin-8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGS8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033658"/>
    <dbReference type="Ensembl" id="ENSMZET00005034831.1">
        <property type="protein sequence ID" value="ENSMZEP00005033658.1"/>
        <property type="gene ID" value="ENSMZEG00005025161.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235535"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="141" mass="15604" checksum="E23A1DD020AB92BA" modified="2019-02-13" version="1">RVNCFSVGSSLFKNLFVVFVPAKNDFVTCCTTVSNKEIPEPILGYLIQRANRPCVNAVVFQTQSGVFCINGRAPWVRAKIVPACPPLNFHLLALMSGPSSSSSLDSSSFNFTSKFLRELLSVSLSHLIIFMTDVPTSWDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DH18</accession>
    <name>A0A3P9DH18_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DH18"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033421"/>
    <dbReference type="Ensembl" id="ENSMZET00005034551.1">
        <property type="protein sequence ID" value="ENSMZEP00005033421.1"/>
        <property type="gene ID" value="ENSMZEG00005024950.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271858"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF170">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="256" mass="28982" checksum="33328D0BB5BE8F21" modified="2025-10-08" version="2">MRLGEWTNMSTTGRPFHRSLYLFILGVGKSSSGNTILGRAAFESKLSLRPVTKLICTLTVVDTPGLFDTCRSQEERKIEIAKCVAFAAPGPHVILVVIQAVRFTGEEKETVRIIHQMFGEEVAGYTMILFTRGDHLEDVRVTIEDRRVSDLVSRCRGRHCVLDNTRSGERAQVERFLRLVDDIIRENDGHHWSRDALRSGDLEDTSCSNNVVEHALAARTPPSLLSRRWQRVYRQVSRWALFYLRIPTASGSGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJA7</accession>
    <name>A0A3P9DJA7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin/ISG15 ligase TRIM25-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJA7"/>
    <dbReference type="Ensembl" id="ENSMZET00005035438.1">
        <property type="protein sequence ID" value="ENSMZEP00005034236.1"/>
        <property type="gene ID" value="ENSMZEG00005025592.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286922"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="48453" checksum="3D2FF056C45B18DC" modified="2019-02-13" version="1">MAQKGVQLESETISCSICLDLLKDPVTTACGHSYCRNCIKGFWDEEDRKGIHSCPQCRKIFTPRPVLEKNTMLAALVEQLKKTGLQAAPADHCYAGPEDVACDVCTGRKRKAIKSCLVCLASYCEKHLEPHYDAAPLKKHKLVTPSKKLQDNICSRHDEVMKIFCRTDQQNICYLCTVDEHKGHETVPAAAERTEKQKELEVRRLNIQQRIQEREKDVKLLQQEVEAINGSADKAVEDSEKMFTELIRLLQKRSSDVKQQVRSQQETEVSRVKELQEKLEQEIAELKRKDGELEQLSHTEDHNQFLHNYPSLSALSESTHSSSIDIRPLRYFEDVTAAVSETRDKLQDILREEWTNISLTVTEVDVLLSPAEPKTRAGFLKYSHEITLDPNTANRWLLLSEGNRKVTLMKQEQSYSHHPDRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJC1</accession>
    <name>A0A3P9DJC1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJC1"/>
    <dbReference type="Ensembl" id="ENSMZET00005036095.1">
        <property type="protein sequence ID" value="ENSMZEP00005034855.1"/>
        <property type="gene ID" value="ENSMZEG00005026052.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0070374">
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15988" checksum="CB894574DED3C2BF" modified="2019-02-13" version="1">MRVPTWFHPNITGVDRPSKSNPGLHFVLFCRRNGALVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLFLVRESQSHPGIYSSDSKPKVTHVMIRCPGKIQILYTLHLVEHYKKNPMVETLGTVLQLKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJC8</accession>
    <name>A0A3P9DJC8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myozenin 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myozenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJC8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034469"/>
    <dbReference type="Ensembl" id="ENSMZET00005035680.1">
        <property type="protein sequence ID" value="ENSMZEP00005034469.1"/>
        <property type="gene ID" value="ENSMZEG00005025756.1"/>
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    <dbReference type="GeneTree" id="ENSGT00950000183027"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:FATZ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:telethonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008438">
        <property type="entry name" value="MYOZ"/>
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    <dbReference type="PANTHER" id="PTHR15941">
        <property type="entry name" value="MYOZENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15941:SF11">
        <property type="entry name" value="MYOZENIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05556">
        <property type="entry name" value="Calsarcin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="211" mass="23736" checksum="998174C2DEFCB19F" modified="2019-02-13" version="1">MPLGTPAPLTKRKKPSKIITDLSHIPQDEYESEPEASEFDLGTKIRTPKDIMLEELSLLKNRGSKMFKMRQQRVEKFIYENNPDIFMGGQIINLGGHFVSKESGPSIIHVKTYVSPWEKAMKGDEGLLATLQTICHIPMPKRNYSRVPCPNGGFEKAITKEEPEPAVVYHHDISCRPSFNRTPIGWVGSSEPSSIHMETDAVPFDGETDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLM9</accession>
    <name>A0A3P9DLM9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004548966.2">
        <property type="nucleotide sequence ID" value="XM_004548909.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLM9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035228"/>
    <dbReference type="Ensembl" id="ENSMZET00005036475.1">
        <property type="protein sequence ID" value="ENSMZEP00005035228.1"/>
        <property type="gene ID" value="ENSMZEG00005026329.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479130"/>
    <dbReference type="KEGG" id="mze:101479130"/>
    <dbReference type="CTD" id="10487"/>
    <dbReference type="GeneTree" id="ENSGT00390000017955"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008078">
        <property type="term" value="P:mesodermal cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF25">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="316"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="472" mass="50357" checksum="3DB155E2019A3B93" modified="2019-02-13" version="1">MAELASLVQRLEVAVGRLEAMSGPGGSAGGSDGGAVSAHVEGFDEIIKGPLSEYLSLSQKIGGDVQKHAEMMKQGFTTERQLLITASTSQKPSDAVLTTLLQPVSSVIQQVQAFREQNRSSPLFNHLSAVSESVPALGWVAMAPKPGPYVKEMQDAATFYTNRVLKDYKDKDKVHVDWVKAYISIWTALQHYIKEQHTTGLTWSKTGAVASAGAAPRSAPAGGPPPPPPGPPPPADLSGPTGGAGDAGADNRNALFASINKGSDITRGLKHVSDNQKTHKNPNLRSQGAPVRSGPKPFASSAARPAASATPTRTLPPVLELEGKKWKVENQEDAQNLVISDTELKQVVYAFKCNKSTLQVKGKINSITLDNCKKMGLVFDDVVGIVEMINCKDVKIQVMGKVPTISINKTDGCHIYLSKDSLKCEIISAKSSEMNVLVPNKDGEFTEIPVPEQFKTVWDGSKLVTTATEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLV5</accession>
    <name>A0A3P9DLV5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein 4A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546363.2">
        <property type="nucleotide sequence ID" value="XM_004546306.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLV5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035176"/>
    <dbReference type="Ensembl" id="ENSMZET00005036423.1">
        <property type="protein sequence ID" value="ENSMZEP00005035176.1"/>
        <property type="gene ID" value="ENSMZEG00005026292.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101480170"/>
    <dbReference type="CTD" id="558146"/>
    <dbReference type="GeneTree" id="ENSGT00530000063320"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000200">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="526" mass="57616" checksum="259F29C7B909D450" modified="2019-02-13" version="1">MFLDERIVTLFKRNAHHTLTYWSVFFSFGLCIAFLGPTILDLQCQTNSTLSQITWVFFAQQFCLLIGSSVGGIFKRTLLTALAALFFSALVISVIFAIIPLCNNVLVLAIAMAVSGLAMGLIDTIANIQLVTIYQKDSAVFLQALHFFIGFGALVSPLIADPFLSETGCGNHTGNETEVIHHFRSMLRNSPIVEHSIPLSNLSHGVEKEESSVHYAFWIMALINLPVPIAVLYLMYREQLIPCCPNGTPRLLDKDELAMESQQGAEGPAVEQIEHEAGVTGHGSIFSCCQNDNLRGLPLSFFMIHILGGMVLFMTDGIVGAYAGFVYTYAVAPPMSLPHKTAGYLASIFWAAITAGRLLSIPLSYRFHPVKLLIFNLAGAIVSVLLLLIFYTSSIFLFVGTCLCGLFLSSIFPCMLAYTEDILDYQGCAISVLVTSAGMGEMVMQVLVGSIIQTEGSYSFLLCGMIIACIGFILFIGLLLFHRMHRNYLTGTSKKSAMVEEPATEQNGEVKTEQIDNEENIQESPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMC8</accession>
    <name>A0A3P9DMC8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxisomal membrane protein PEX14-like KPWE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMC8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035342"/>
    <dbReference type="Ensembl" id="ENSMZET00005036591.1">
        <property type="protein sequence ID" value="ENSMZEP00005035342.1"/>
        <property type="gene ID" value="ENSMZEG00005026413.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000174755"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="1">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="92" mass="9825" checksum="AA855C5E5B6BEC76" modified="2019-02-13" version="1">PVSPQSPAGSAEAKPRQRIQVMQLVQEGKEVPGVTKVDIEPSNQNPTPSTMERMLKPWETASSSPESDPGLSAFASGPCCSRQCSVWGNQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNQ6</accession>
    <name>A0A3P9DNQ6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Myosin-7B</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005035918"/>
    <dbReference type="Ensembl" id="ENSMZET00005037184.1">
        <property type="protein sequence ID" value="ENSMZEP00005035918.1"/>
        <property type="gene ID" value="ENSMZEG00005026814.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160318"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14927">
        <property type="entry name" value="MYSc_Myh7b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000003">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000010">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000024">
        <property type="entry name" value="Myosin heavy chain, isoform J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF29">
        <property type="entry name" value="MYOSIN-7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8 13" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="16">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="86"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="13">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="839"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1190"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1330"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1937" mass="224329" checksum="16E29D7A2908A30B" modified="2019-02-13" version="1">MSRFLDMAEFGEAAHYLRLTNLEQLAAKAQAFDGTKRIWMPDETEAYTEVEIRELNGDKTTVETKDGRFLIVKEDDLQPMNPPKFDMIEDMAMLTHLNEASVLFNLRRRYSMWMIYTYSGLFCVTVNPYKWLPVYTPEVVTAYKGRRRADMPPHIYAIADNAYTDLLQNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGENVKKGGSLEDQIIEANPAMEAFGNAKTIRNDNSSRFGKFIRIHFGPTGKLASADIDIYLLEKSRVVFQQPGERSYHIYYQILSNHKPELQDMLLVTTNPYDYHFCSQGVTTVEGISDGEELRLTDRAMDTLGFTPEEKYGCYKIVGAIMHFGNMKFKKKQREEQAEADGTESADKAAYLMGISSADLLKGLLNPRVKVGNEFIVKGQTVEQVNYAVAALAKATYDRMFKWLVGRINSSLYTSLPRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFILEQEEYKAEGIEWTFIDFGLDLQACIDLIEKPMGILSIMEEECMFPKATDHSFKTKLYDNHLGKSPNFQRPRLDKKRKYETHFELVHYAGVVPYNITGWLDKNRDPLNETVVALFQKSSNKLMAGLFENYISSDMPIDPKAETKQRRKKAASFQTVSQLHKENLNKLMANLRSTQPHFVRCIIPNESKIPGVMDPFLVLHQLRCNGVLEGIRICRKGFPNRILYAEFRQRYRILNPFAIPEDSFVDNRKAVEKLLGSLDIDHSQYKFGHTKVFFKAGLLGQLEDMRDNRLSQILTTVQAICRGKLMRMERQKLMDAVMVIQFAIRAFFSVRTWPWMILFFKLRPLLRSAQVEKELAALNEEFKKLKEAYGRSEVKRKEAEERQVALVQEKNDLALQLQAEQDNLMDAEDRCNQLIQSKISLESKLKEMQERLEDEEEVSSTLTSKKRQLEDEVLSLKRDVDDLEMTLAKVEKERHGVENKVKNLSQEMSVLDESIASLSREKAALLEAHQQALNDLQAQEDKVNMLAKAKARLEQQVDSVETSLELEKKVRTDLERTKRKLEGDLKLSMDSVRDLENQKEEQEERLRKKDFELVQLQSKLEDEQSLAAQLHKKIKELQTRIEELEEALEAERAWRSKAERQRNDIARELEELGEKLEEAGGASAAQIALNRKREADFLKLRRELEEAGLHHEATAATLRKKHSDMVTELSEQIDALQRVKQKLEKEKVEFRLEADDLAASVEQLSRSKAAVEKMCRVYEDQLNESRSRADELQRQLSEVNAQKARAVTETTEYRRRLEERDATIAQLQRLKVGACQNVEDMKKRLEEESKARVALAHAVQASRHDCSLLREQLEEEQEAKAELQRALSTANSQVVQWKAKYETDAVLRIEELEEAKKKLVVRLQTLEEVAEASQAKCSSLEKTKQRLQIEMEDLMVQLERSNAAALALDKRQRNFDMVLSDWKLKFDECQMELEASQKESRSLSTELFKLKNCYEEALDQLETIKRENRNLQEEIVDLTDQISQEGKTIHELERMKKILDVEKSDIRAALEEAEGTLEHEESKILKYQMELEQIRAEMDRKIAEKEEEIDSLRGSQQRSLETMQANLEAEIRHRSEAVRLRKKMESDLNEMEIQLGNANRQQAESQRIMRHLQIQVKEQQVELEEKVQLTNQLREQIALLERRCSLMSAEEEELRGVLEQTDRTRKMAEHELVEVSERVNLLAAQNTGLMNQKKKLEADLSVLTGEVDEAMQESHNAEEKAKKAISDAAMMAEELKKEQDSSTMLERMKKNMESTVKELQVKLDETEQMALRGGKKQLHKLETTVRALQTELTLEQKKSEEYQKGVRRYERKVKELTYQSEEDKKTLLRMQELIERLQAKVKSYKRQAENAEEQVSCSTVRFRKVQHELDEAEERADIAETTVNKLRIRTREQTSKVAMVSYAWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DP08</accession>
    <name>A0A3P9DP08_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 2 member 9</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DP08"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035961"/>
    <dbReference type="Ensembl" id="ENSMZET00005037227.1">
        <property type="protein sequence ID" value="ENSMZEP00005035961.1"/>
        <property type="gene ID" value="ENSMZEG00005026839.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005037228.1">
        <property type="protein sequence ID" value="ENSMZEP00005035962.1"/>
        <property type="gene ID" value="ENSMZEG00005026839.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159192"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070837">
        <property type="term" value="P:dehydroascorbic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17432">
        <property type="entry name" value="MFS_GLUT_Class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000029">
        <property type="entry name" value="solute carrier family 2, facilitated glucose transporter member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="32"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="525" mass="58044" checksum="564F6EF7BB921EEB" modified="2019-02-13" version="1">MDEQKDDQIDQDDSTNNSEKEQSLTACLLCAAFFGSLGSSFLYGYNLSVVNAPALYIKAFYNKTWIERYGEPISAETVTLLWSVTVSIFSIGGLFGALSATLIIKVLGRKGTLLLNNSFAVIAAVLLSLGEMSRSFEMLIIGRLIMGVDSGIALSALPMYLGEISPKHFRGMIGQFNSILICLGVFTGQVLGMPELLGQESTWIYLFSFLALPAMLQLCVLPFLPESPRYLLMERRDEAGAEKAFQRFLGKKDVSQELEEVHMEARAQDKLHTVSVLQLLKSPAVRWQLITVIITMACYQLCGLNAIWYYTNGILREAGFTESILPYITLSTGAIETLAAIISGLVIERIGRKPLLIFGFFSMAVFFSLLTVFLNFQDRVSWMPYLSYVCILAVIASFCSGPGGIPFILTGELFEQSYRPAAFMIAGTVNWLSNFAVGLLFPFIQETLQSFSFLVFVAVCILGSIYLYVVLPETKNKTFMDISQSFAKINKMPIPSPGQEMELVLSINSDTNGKAQDATKMQTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DP67</accession>
    <name>A0A3P9DP67_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Neuronal vesicle trafficking-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Neuron-specific protein family member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endosome</location>
            <location evidence="6">Multivesicular body membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Golgi apparatus</location>
            <location evidence="20">Golgi stack membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Recycling endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NSG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545248.1">
        <property type="nucleotide sequence ID" value="XM_004545191.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DP67"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036078"/>
    <dbReference type="Ensembl" id="ENSMZET00005037351.1">
        <property type="protein sequence ID" value="ENSMZEP00005036078.1"/>
        <property type="gene ID" value="ENSMZEG00005026922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478645"/>
    <dbReference type="KEGG" id="mze:101478645"/>
    <dbReference type="CTD" id="27065"/>
    <dbReference type="GeneTree" id="ENSGT00390000000483"/>
    <dbReference type="OrthoDB" id="8924576at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009431">
        <property type="entry name" value="NSG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28546:SF3">
        <property type="entry name" value="NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28546">
        <property type="entry name" value="NEURONAL VESICLE TRAFFICKING-ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06387">
        <property type="entry name" value="Calcyon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00007767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="185" mass="20543" checksum="1510C55331F061CA" modified="2019-02-13" version="1">MVKLGNNFSEKTNGKVVSEDGFDTIPLITPLDASQLQFPPPDKVVVKTKADYDGESKKGKLRSPKIAEFSISIIEGVSERLKVTLLVICALAFLMCVVFLVVYKVYQYEQPCPDSFVYTQGRCMPAGLYGNYPPQGPGGRGRLFTLINHYNIAKQTITRSVSPWVTIMSEEKVTQQETETAQKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPK6</accession>
    <name>A0A3P9DPK6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adenylosuccinate synthetase isozyme 1</fullName>
            <shortName evidence="11">AMPSase 1</shortName>
            <shortName evidence="11">AdSS 1</shortName>
            <ecNumber evidence="11">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenylosuccinate synthetase, basic isozyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Adenylosuccinate synthetase, muscle isozyme</fullName>
            <shortName evidence="11">M-type adenylosuccinate synthetase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADSSL1</name>
        <name evidence="11" type="synonym">ADSS1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004540843.1">
        <property type="nucleotide sequence ID" value="XM_004540786.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DPK6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036208"/>
    <dbReference type="Ensembl" id="ENSMZET00005037482.1">
        <property type="protein sequence ID" value="ENSMZEP00005036208.1"/>
        <property type="gene ID" value="ENSMZEG00005027014.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469135"/>
    <dbReference type="KEGG" id="mze:101469135"/>
    <dbReference type="CTD" id="122622"/>
    <dbReference type="GeneTree" id="ENSGT00390000015553"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03126">
        <property type="entry name" value="Adenylosucc_synth_vert_basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
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    <sequence length="456" mass="50266" checksum="AC71BE921DF233A6" modified="2019-02-13" version="1">MSLSWSGKDQKNANQPAATGQKRPRNDAGNKVTVVLGAQWGDEGKGKVVDLLATEADIVCRCQGGNNAGHTVVVDGKEYDFHLLPSGIINPKSISLIGNGVVIHLPGLFEEGDKNDKKGLKGWEKRLIVSDRAHLVFDFHQVVDGLQETERQAQEGKNIGTTKKGIGPAYSSKASRTGLRVCDLLGDFKDFSTRFKNLVQQYQSMYPSLTVDVEDQLKKLKEFAERLRPMVRDGVYYMYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGACTGLGIPPMNIGEVFGVAKAYTTRVGIGAFPTEQLNAIGELLQTRGHEVGVTTGRKRRCGWLDLVIVRYAHMINGFTAIALTKLDILDVLDEIKVGVAYKLNGKRIPHFPANMDVLQKVEVEYETFPGWKTDTSAARKWNDLPVKAQNYIRFIENHIGVPIKWVGVGKSRECMIQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ86</accession>
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    <sequence length="103" mass="12084" checksum="6FDE73391D757032" modified="2019-02-13" version="1">RKRERETDSLLCPVCLSVFTKPVSIPCGHNFCMNCITEYWSTLSVLQCPLCKEMFYTRPLLRVNPQCWFQSLCKCTVYKIWGKLQSAETEEVTWTSDETFLSR</sequence>
</entry>
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    <accession>A0A3P9DRL7</accession>
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        <property type="entry name" value="CHYMOTRYPSIN-LIKE PROTEASE CTRL-1-RELATED"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="16"/>
            <end position="252"/>
        </location>
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        <location>
            <begin position="257"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="341" mass="35572" checksum="AB57094A1B3D2C50" modified="2019-02-13" version="1">MFSCALSALSACGSRAVNSSFTGVGDAAAGSWPWFADIRVDGGPSFINAGFLVLPTSFGFGGSLINDQWVLTAASTMSLDFSSRVVYLGRNSRSGPNPNEVNRTVVNITCHPGFNSSTRENDICLLKLSAPVNFTDYIRPICLASQNSTFNNETSSWTIGFNFFVISNNLQEANVPIVGNSECKASNPRVPDSIICTGRIDSCLTSFGAPLMTQSGSVWLQSGLLIVLGCSGRPSTYTPVSQYQQWISDTVTGTPPGFFTFPSPDSSLQTTAPPTASPTSPPTAPPTAPPTSPPTAPPTAPPTAPPTAPPTSPTCAGVFCSGENLGPVLRTSLSRLAGLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSY7</accession>
    <name>A0A3P9DSY7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSY7"/>
    <dbReference type="Ensembl" id="ENSMZET00005039198.1">
        <property type="protein sequence ID" value="ENSMZEP00005037850.1"/>
        <property type="gene ID" value="ENSMZEG00005028240.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286952"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000151">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000380">
        <property type="entry name" value="zinc finger protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="300" mass="33724" checksum="62CF522E4646EC57" modified="2019-02-13" version="1">VLHKQGTVCLFSPSDQHGARSQRSQEADKPHRRKGEKKHTCDECGKGFTVKASLKQHQVIHTGERPFNCDMCGKSFSLKGSLKKHQLIHSGVKAYSCDQCGRAFTRSSHLQSHLVTHSGIKPYSCDQCGRAFTRSSSLQKHLLTHSGIKPYSCDECGKGFTVRDKLKQHQVIHTGERPFSCDMCGKSFSLKDSLKKHQLIHSGVKAYSCDQCGRAFTHSSSLQRHLVTHSGIKPYRNYSCDQLQLPNTNIYKFCRQGKDKTIQACKISAAQRCSNLVQPLANNVHKVYFMIDRSPTRMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTF3</accession>
    <name>A0A3P9DTF3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004543324.1">
        <property type="nucleotide sequence ID" value="XM_004543267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTF3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037532"/>
    <dbReference type="Ensembl" id="ENSMZET00005038841.1">
        <property type="protein sequence ID" value="ENSMZEP00005037532.1"/>
        <property type="gene ID" value="ENSMZEG00005027987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463883"/>
    <dbReference type="KEGG" id="mze:101463883"/>
    <dbReference type="CTD" id="558312"/>
    <dbReference type="GeneTree" id="ENSGT00550000074828"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043009">
        <property type="term" value="P:chordate embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="114" mass="11724" checksum="E6C7129D58A1DC26" modified="2019-02-13" version="1">MRYVAAYLLAALGGNENPDAKDIKKILESVGIETDDTRLDKVISELKGKNVNDVITTGYGKLASMPAGGAVAVASSAAAGSGGAAAPAAAEEKKEEKKEESEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DU11</accession>
    <name>A0A3P9DU11_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DU11"/>
    <dbReference type="Ensembl" id="ENSMZET00005039062.1">
        <property type="protein sequence ID" value="ENSMZEP00005037743.1"/>
        <property type="gene ID" value="ENSMZEG00005028139.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000214780"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="96" mass="10828" checksum="E93CC02CD514E29F" modified="2019-02-13" version="1">ITSQLKTPIPHMNQMDQTKICCSVCLDLLKDPVTIPCGHSYCMNCIKSFWDEEERENLQLPSVPEDFHSEACPGEKHHVSRFSGGAEEDWTPSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AR24</accession>
    <name>A0A3P9AR24_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AR24"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000151"/>
    <dbReference type="Ensembl" id="ENSMZET00005000191.1">
        <property type="protein sequence ID" value="ENSMZEP00005000151.1"/>
        <property type="gene ID" value="ENSMZEG00005000185.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155760"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08805">
        <property type="entry name" value="Death_ank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000010">
        <property type="entry name" value="Ankyrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF71">
        <property type="entry name" value="ANKYRIN 1, ERYTHROCYTIC A ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="148" mass="16712" checksum="783E0C2668287200" modified="2019-02-13" version="1">LSFIFMFSAASMSAMERTELKMAVIAEQLGLSWAELARELQLSVDDINKIRVENPNSLLEQSSALLNLWATLEGKRAKMESLYTALKSIDRMDIINMLEGQPPQPVRQGSRDVNRRRHSERDHLSPGMTNGKRPPQIPWPGLISVPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASG3</accession>
    <name>A0A3P9ASG3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc phosphodiesterase ELAC protein 2</fullName>
            <ecNumber evidence="6">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">ElaC homolog protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ribonuclease Z 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">tRNA 3 endonuclease 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">tRNase Z 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with PTCD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
            <location evidence="4">Mitochondrion nucleoid</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004556432.1">
        <property type="nucleotide sequence ID" value="XM_004556375.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASG3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000553"/>
    <dbReference type="Ensembl" id="ENSMZET00005000618.1">
        <property type="protein sequence ID" value="ENSMZEP00005000553.1"/>
        <property type="gene ID" value="ENSMZEG00005000530.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483694"/>
    <dbReference type="KEGG" id="mze:101483694"/>
    <dbReference type="CTD" id="60528"/>
    <dbReference type="GeneTree" id="ENSGT00730000111191"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000014">
        <property type="entry name" value="Zinc phosphodiesterase ELAC protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="26">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="800"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="820"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022759"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030689"/>
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    <evidence type="ECO:0000256" key="20">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00032104"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00046098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="853" mass="95660" checksum="F2ABF471FEA59DC4" modified="2019-02-13" version="1">MNRLHVRLWHFTSLFVNGRTLPAPVRCDSSLHRSVFQLFRTMATTTTNNKNNLPKKAKQKEPLRRVKTKENRSKRGDVHGPSTVYLQVVGAGSRDNAASVYVFSEFNRYLFNCGEGTQRLMQEHKLKAARLDNIFLTRLSWENVGGLSGMILTLKDTGVPECVLSGPPQLENYLNAIKSFSGPLEDIKLSVRPYTEETYSDDTMTVYQVPIFAKSRDNDRNRSHRSGRNSPTQATPQKADVSSADDPGERRTAARDSSLVVAFACKLHPKKGNFLVAQAKELGLPVGTAAIGPIIAALKDGKSIVHEGKEIRPEQVCTPTDPGPVFIMVECPSEEFLGALCTNQQLGRYQTGGTEDPAALVVHMTPESVLKTDQYKKWMERFPSTTEHLILNEHACTIHNIRSHKIQAQLNMIHPEIFPQLKAYKAKEPQAALHVPNVRAECLLKFQLRPVMEWQRDAIPSCNSEEFVKEASEVPNFLAEVDKCRKICSAGSAELSGQGGKYPEVVFLGTGSALPMKIRNVSGTLVNISPSQSLLLDCGEGTFGQLCRHYGDDVDDALSKIATVFISHLHADHHTGLVKLLYQRERALATLGKPFSPIFLVAPVQIMTWLNQYHDYCEEILSHINLIPNKFLCDTVEVPKQRTKSFIQAMLKKNNLQRFHTCLVRHCKNAFACSFTHQAGWKLAFSGDTMPCDAFVHIGKNATLLIHEATLEDELEEEAVEKRHSTTSQAIGIGMKMNADFIMLNHFSQRYAKIPLFSEDFNDRVGISFDHMRIRFDDSKIIPKLIPALKTLFAEELGEMEERRERREMRYPRGSSSEVTSEHKTGAPDVGRGAKRDQEETAAHVETKRLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AT63</accession>
    <name>A0A3P9AT63_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA binding protein fox-1 homolog 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding protein that regulates alternative splicing events.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004556445.2">
        <property type="nucleotide sequence ID" value="XM_004556388.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AT63"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000871"/>
    <dbReference type="Ensembl" id="ENSMZET00005000947.1">
        <property type="protein sequence ID" value="ENSMZEP00005000871.1"/>
        <property type="gene ID" value="ENSMZEG00005000781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487767"/>
    <dbReference type="KEGG" id="mze:101487767"/>
    <dbReference type="GeneTree" id="ENSGT00940000159924"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12407">
        <property type="entry name" value="RRM_FOX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000004">
        <property type="entry name" value="RNA binding fox-1 homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025670">
        <property type="entry name" value="Fox-1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034237">
        <property type="entry name" value="FOX1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017325">
        <property type="entry name" value="RBFOX1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047131">
        <property type="entry name" value="RBFOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597">
        <property type="entry name" value="ATAXIN 2-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15597:SF25">
        <property type="entry name" value="RNA BINDING PROTEIN FOX-1 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12414">
        <property type="entry name" value="Fox-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037932">
        <property type="entry name" value="Ataxin_2_bd_A2BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="152"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="7">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="7">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="7">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with RNA" evidence="7">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037932-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="378" mass="41236" checksum="1969F5B5A2F3034E" modified="2019-02-13" version="1">METPSWAGNTLCKSGSIAVFGNVVYSGLLNDHLWHLGVPLFTRLGNQEATNPPEAMAQPYTPAQYPPPPQNGIPAEFAAPHPLPTQDYTGQSRVPEHAMTLYTPTQTHSEPAGTDNSTPATTTAPTDDVTQTEGSQQLQLQHSDSSEKQQPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSTDADRAREKLNGTIVEGRKIEVNNATARVMTNKKVANPYTNGWKLNPVVGAVYGPELYAVTGFPYPATGATVAYRGAHLRGRGRAVYNTFRTAPPPPPIPAYGAVVYQDGFYGAEIYGGYAAYRFAQPTTTAAYSDSYGRVYATADPYHHTIGPAATYSVGTMASLYRGGYSRFTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATS5</accession>
    <name>A0A3P9ATS5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial translation release factor in rescue</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRES1, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts (via C-terminus) with MTRES1 (via S4 domain). Associates with mitoribosomal S39 large subunit, peptidyl tRNA and nascent chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATS5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001125"/>
    <dbReference type="Ensembl" id="ENSMZET00005001213.1">
        <property type="protein sequence ID" value="ENSMZEP00005001125.1"/>
        <property type="gene ID" value="ENSMZEG00005000938.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Chromosome 12 open reading frame 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="12">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="163" mass="18314" checksum="21B6166CB15EB9D4" modified="2019-02-13" version="1">VMSVFVPITSFVRMRLTWIGSLLLRPPPTGLRCVLAAGKKDLIDLPVLVEDELEEQFVRGSGPGGQATNKTSNCVVLKHIPTGIVVKCHQTRSVDINRKRAREIMREKLDVAYKGELSEVVMKKKESVLRKQEKRRKANENLERKRLLKEALAADSKPGNDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUG7</accession>
    <name>A0A3P9AUG7_9CICH</name>
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        <submittedName>
            <fullName evidence="15">Olfactory receptor 52K1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUG7"/>
    <dbReference type="Ensembl" id="ENSMZET00005001138.1">
        <property type="protein sequence ID" value="ENSMZEP00005001052.1"/>
        <property type="gene ID" value="ENSMZEG00005000899.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286905"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000024">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF391">
        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="32"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="296" mass="33663" checksum="9E86C8B5E566F747" modified="2019-02-13" version="1">THFILDGFSELGELRPFLFIPFSFMFVVSLFANSLLVYVIVSQRSLHSPMYILIASMACIDLSLPVFFVPHMLLSFLFDWRGISLIGCLVQMHFIHFFGTFQSTLLVWMALDRYFAICTPLYYHNHMILSRFIAFLIPLVVRNVLMITLLVCLAGKLPFCFRNVINHCFCEHMALVELACGSTTINNLVGLMAVFLIPVLDFVFIAASYVVIFSSVLKSSRSGVKALHTCITHIMVITVSLILALTAFLSYRIRNGLPAASRVFFSTMYLLFPSCFNPVVYGIRTNEIRQHILKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AV25</accession>
    <name>A0A3P9AV25_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="RefSeq" id="XP_004554729.1">
        <property type="nucleotide sequence ID" value="XM_004554672.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AV25"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001483"/>
    <dbReference type="Ensembl" id="ENSMZET00005001573.1">
        <property type="protein sequence ID" value="ENSMZEP00005001483.1"/>
        <property type="gene ID" value="ENSMZEG00005001230.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478506"/>
    <dbReference type="KEGG" id="mze:101478506"/>
    <dbReference type="GeneTree" id="ENSGT00940000153431"/>
    <dbReference type="OrthoDB" id="6496718at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="10">
        <location>
            <begin position="120"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="THAP-type" evidence="10">
        <location>
            <begin position="395"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="721"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="783"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1035" mass="117004" checksum="353CE3E008EDBE95" modified="2019-02-13" version="1">MPSYAFLDCLEHYLLTGKFQVNTSKSWKKLVSKDSKKFTYKDGCLWRSYRGRLLRVVRSDEEIREILIQYHNNNNHARRERAVREIMLMYYWVGVTAAVKNWIKACDVCQNQPTKELANLRVQFCLVYGCDSSSYIHPEITFHRFPKDPGQRQKWLTVAQRDEGSLRSNSYICSRHFDPSCYTLNEDGQPTLSSDAVPSIMPDEEVPIPSDEEVLLSNTLEDLISAAAANTETEKPPHPATDQSETPMELQEHQYCSSAPDSTAVQTVKEHTRRKTVIEPTFTTYNHVARYLSHRILPTQSKKNRSALKRMAKRFGLIDGVLMYTRASRPLSVPRSREEVNSILREFHDSKGHYGQGVCQQEISKHFHWGSMTRDLASWIANCQTCLNRTKRKWMRCSVLGCTNCCGPVERRLGLTFHKFPLHNATLLAKWLKATGRPNWHPRLRSSICSIHFTDDCFSHSGEVITLNPDAVPALSVHTDSAVPSRGASQPAVGEEQAIFAKYDAVELYLTKRTYPPGLNYVEKNTFRRFCKKFAIKDGVLHTVKGDQMRLVLRNRQQVETALVDYHNELNHLDVNKCLRLLNERYFWRTMRPDVVQWINNCSQCSMKKTKKPNHQAEARGLAVQTSAQLQELTSHDLDSANDEDTDSDGDAEEQLTVNSKDTVDEPSSSLSSQTEIHDNPQPKIPILLHLKNPINLQPRSPKIPSVTKLLSMKRMTSSHFEIHKDPESSKKQKRIENPINPQPEKLAQPQEQEKTSSPQGNNGTQHCIQAQLVLEQHAPLQHIQAPSQKSPPEAHTSTQIRSHCSVQRTVKKKRGPEADSSAKWSSSSGLEPVMALSTKPWPVFTIGSSAVEKTAKPSPNADSSAVFYRPIRLQARTVIQQCSHAKIKLKPAVDGADAQWAEIQQGLVVYVCFFHGATEDVTNEMANTLMTTRLFRKHSGHCVSLLDLPGSILFVPQDSLLGKPAPNRRMQYKGGCELWWGAQLFSSLVSACRELMTGSAKCTNAGVKVEHGLYGRKQEIALNSVEPQSVLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVA5</accession>
    <name>A0A3P9AVA5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MAGUK p55 scaffold protein 2a</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004568652.1">
        <property type="nucleotide sequence ID" value="XM_004568595.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVA5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001559"/>
    <dbReference type="Ensembl" id="ENSMZET00005001650.1">
        <property type="protein sequence ID" value="ENSMZEP00005001559.1"/>
        <property type="gene ID" value="ENSMZEG00005001260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475212"/>
    <dbReference type="KEGG" id="mze:101475212"/>
    <dbReference type="CTD" id="562207"/>
    <dbReference type="GeneTree" id="ENSGT00940000155348"/>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10832">
        <property type="entry name" value="PDZ_MPP6-MPP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000069">
        <property type="entry name" value="MAGUK p55 subfamily member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000047">
        <property type="entry name" value="MAGUK p55 subfamily member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="10">
        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="141"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="8">
        <location>
            <begin position="350"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="552" mass="61868" checksum="7B50E96FEC5BDFE4" modified="2019-02-13" version="1">MPVASTRTEPVPQVLDAMSDSTASSTTANDLDLIYLKGIMESPLEQEESLKEPRLSPVRENNVELLQEILRDLDPFTNRSDTAAELARILTQPHFQSLLETHDSVAAQACESPPPSPCDFVDHEPEDSQAHNHLPPDAIRMVGIRKIAGEHLGVTFKVEGGELVIARILHGGMIDQQGLLHVGDIIKEANGREVGRDPRVLQEELQAASGIVVLKILPSYHESIPPVQVFFKCHYDYDPANDNLIPCKEAGLRFETGDILQIVNQDDVNWWQARHVEGGSAGLIPSQMLEEKRKAFVKRDVELAPAGNLCTGVGGKKKKKMMYVTTKNAEFDRHEILLYEEVAKVPPFKRKTLILIGAQGVGRRRLKNKLLLRDPQLFGTIIPYTSRKPKKGERESRMFAFTTRSKMETDIKNGRYLEHGEYEGNLYGLKIDSIHEVVEAGRVCILDANPQSLKVLRTSEFLPYIVFLQAPEFEVLKAINQSAAEAGVVTKTLMDEELQRTCDESAKIQTAYGHYFDLSIVNDNLDETYRTVKAALETVSKNPQWVPVTWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXF8</accession>
    <name>A0A3P9AXF8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with SLC19A2. Interacts with NTRK1/TRKA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562939.1">
        <property type="nucleotide sequence ID" value="XM_004562882.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXF8"/>
    <dbReference type="Ensembl" id="ENSMZET00005002483.1">
        <property type="protein sequence ID" value="ENSMZEP00005002375.1"/>
        <property type="gene ID" value="ENSMZEG00005001881.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464165"/>
    <dbReference type="KEGG" id="mze:101464165"/>
    <dbReference type="CTD" id="393380"/>
    <dbReference type="GeneTree" id="ENSGT00940000164506"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03156">
        <property type="entry name" value="uroplakin_I_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF216">
        <property type="entry name" value="TETRASPANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="242" mass="26200" checksum="47CEE78E45C77EB9" modified="2019-02-13" version="1">MGCFQFLKFMMFAFNGIIFLAGAAILGVGIWVKVDSGSVLTFLGKIDNMPAELSQVLNVGYLLIAIGILLVVIGFLGCCGAMRESKCMLLLFFIIVLLIFIAEVAGAVVILVFRPLAEELFNKIGQEAVKSIKQGYGNNTDITGLWNSTMSTFKCCGFYNSSEFKESPYYKNHNNTFPPQCCLNPGSTCTDGTITGCFPKIRKLIDDNTAAIVGVALGIAALELCAMAVSMILYCRIKSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXL5</accession>
    <name>A0A3P9AXL5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXL5"/>
    <dbReference type="Ensembl" id="ENSMZET00005002283.1">
        <property type="protein sequence ID" value="ENSMZEP00005002182.1"/>
        <property type="gene ID" value="ENSMZEG00005001737.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166432"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF114">
        <property type="entry name" value="PCDH2G3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="95"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="208"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="305"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="429"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="650" mass="70968" checksum="745B0F2DAF25AEE6" modified="2019-02-13" version="1">MLAIIGARFVIEEAHDADVGQNSVQQYNLKKNDNFILSVNGNTIEVVLEKELDREKQQEMNLILTALDGGSPQRSGTLVIHVTVLDANDNAPVFSQAVYKASLPENSRLDTVVITVSASDADEGVNGDVTYDFGHVTEEVKKIFSIDRKVGDIRVIGVVDYETTTSFEIRVKAKDGLGLSSYAKVMISITDVNDNAPVVNLKSLTNPIPENTPPGTEVGIINVQDRDSGNNRQVRCSIQQGFPFKLVPSIKNYYSLVTTGQLDRELLSDYNITITATDQGSPPLSSSKSVQLSVTDINDNPPVFEEQSYSAYVSENNKPGSTLCSVSARDPDWRQNGTVVYSLLAGEVNGAPVSSYLSVNGDTGVIHAVRSFDYEQFRSFKVHVMARDNGSPPLSSNVTMSVFISDVNDNSPQILYPSPEGNSFMTELVPKAAHGGSLVSKVIAVDADSGQNAWLSYQIVKSTDPGLFTIGVHSGEIRTQRDISESDSMKQNLVVAVKDNGQPSLSATCSMYLLISDNLAEVPELKDLSYNESNSKLTSYLIIALVSVSTFFLTFIIIILGLRFCRRRKPRLLFDGAVAIPSGYLPPNYADVDGTGTLRSAYNYDAYLTTGSRTSDFKFVTSYNDNTLPFSSTLSSQNSFFKCLEQKLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZX5</accession>
    <name>A0A3P9AZX5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic elongation factor 2 lysine methyltransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014263585.1">
        <property type="nucleotide sequence ID" value="XM_014408099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZX5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003164"/>
    <dbReference type="Ensembl" id="ENSMZET00005003292.1">
        <property type="protein sequence ID" value="ENSMZEP00005003164.1"/>
        <property type="gene ID" value="ENSMZEG00005002454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484258"/>
    <dbReference type="KEGG" id="mze:101484258"/>
    <dbReference type="CTD" id="196483"/>
    <dbReference type="GeneTree" id="ENSGT00940000164788"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029426">
        <property type="entry name" value="FAM86_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14904">
        <property type="entry name" value="FAM86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAM86 N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="327" mass="36120" checksum="822DD375B83ED224" modified="2019-02-13" version="1">MALSERSSVQGSVKEVLREFQVSFFALTRLPSFPWTFVEKDLQSSGSSELISQVLKQTCLHPLCRKFPPSVRYRRLFLSQLIRRLEASGCEPLDELYDALAEVVGAEETMECYKSYLLPAGGAVSLMENIALISEGTTGLVTWEAALYLAEWALENQQVFTGRTVLELGSGAGLTGIAVCRSCSPKRFIFSDCHSTVLQKLRDNVRLNGLSEQTTPAVSVEKLDWTAISEEELREIGADVIIAADVVYDPDIAGSLAKLLSIVLRCSSAEVLPQVFICSTIRNLETYGGFKQQLEAEGVGHEVIPAPVNHVFPYNRQSAIELIKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0B2</accession>
    <name>A0A3P9B0B2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adipocyte plasma membrane-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004575357.1">
        <property type="nucleotide sequence ID" value="XM_004575300.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0B2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003309"/>
    <dbReference type="Ensembl" id="ENSMZET00005003441.1">
        <property type="protein sequence ID" value="ENSMZEP00005003309.1"/>
        <property type="gene ID" value="ENSMZEG00005002551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471862"/>
    <dbReference type="CTD" id="57136"/>
    <dbReference type="GeneTree" id="ENSGT00440000039984"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000041">
        <property type="entry name" value="adipocyte plasma membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF130">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="10">
        <location>
            <begin position="200"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="415" mass="46420" checksum="7F5BC9B369C50606" modified="2019-02-13" version="1">MNESAGLRFRRLHRPQVITDELPEQRRKGSSTYSGKIFRVTLLSLGVLLLLPLLVIILILESPIKPEVFTLKEPPMMKGCWEPNLKLREAQRLFEDQLVGPESIANIGDVLFSGTADGKIVKLVGRRIHMVTRLGKLPCGSREDEPNCGRPLGIRVGPNGTLFVADAYLGLFEVNPTTGEATRLVNGGQVVAGRKLSFINDVAVTQDGKKVYFTDSSSRWQRRDYMHLIMEATPDGRVLEYNTETKELTVVMEDMRFPNGIQLLPDEESVLVAETTMARIRRVHVAGLNKGGMDTFVDNLPGFPDNIRPSSTGGYWVAMSAVRPNPGFSMLDFLSQRPWIKKFIFKLFSQDILMKFVPRYSLVAELHDGGVCTRSFHDPNGLVAAYISEVHEHDGNLYLGSFRSPYIAKLDLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0L6</accession>
    <name>A0A3P9B0L6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Muscarinic acetylcholine receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Postsynaptic cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014266173.1">
        <property type="nucleotide sequence ID" value="XM_014410687.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024659143.1">
        <property type="nucleotide sequence ID" value="XM_024803375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0L6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003419"/>
    <dbReference type="Ensembl" id="ENSMZET00005003551.1">
        <property type="protein sequence ID" value="ENSMZEP00005003419.1"/>
        <property type="gene ID" value="ENSMZEG00005002651.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472526"/>
    <dbReference type="KEGG" id="mze:101472526"/>
    <dbReference type="CTD" id="100004742"/>
    <dbReference type="GeneTree" id="ENSGT00940000160394"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15049">
        <property type="entry name" value="7tmA_mAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF180">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="88"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="473" mass="53091" checksum="150F2F1D3C1FFB5F" modified="2019-02-13" version="1">MCHYIPHLMTSGRRLHVNCCRWTDGQADSGKLSSSNTPGNMEPTPTLLRLSVNTSRVPPLSPPYPYSTAQLVLIAMVTTSLSILTVLGNTLVILSIKVNRHLQMVNNYFLLSLAVADLIIGLFSMNVYTLYKLQGRWLLGPVLCDAWLVLDYVASSASVLNLLLISLDRYFCLTRPLSYPVRRTGRMACLMIAAAWLLSFILWAPAILSWQTDKGGRVVPHDQCYIRLLVSPAVTMGTTLPSFYLPAIIMIGLYSHLSVASYSRMSVLMPNQGALRASSPSLKDFLLRRRGMGTSDPCSDLTPNQLQSCTPKTRRKKKTCRSPDDTAQAESSWRHWKHPSQTAVKPTGDEDHNKTESEDSFNADLHRAASAVFSSCPDISSHERRRQRVMARERRVTRTILAIILVFVLTWTPYNVMAVVAAFCHCRIPDALWTTGYWLCYVNSTVNPGCYALCNVTFRKTFCSLLRCRCRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2F5</accession>
    <name>A0A3P9B2F5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004555913.2">
        <property type="nucleotide sequence ID" value="XM_004555856.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2F5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004064"/>
    <dbReference type="Ensembl" id="ENSMZET00005004232.1">
        <property type="protein sequence ID" value="ENSMZEP00005004064.1"/>
        <property type="gene ID" value="ENSMZEG00005003149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474593"/>
    <dbReference type="GeneTree" id="ENSGT00390000000464"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="357" mass="39581" checksum="3C04B3AF6EBC0461" modified="2019-02-13" version="1">MSFCFNFDLPAQTTGPGDVDGNELQHGNKDHAVVSVEDGPKPAQPVKEASEHFPPSDPQFLLMDAIFETVTVGTLPPLHFLNETVFEKTASEREDSEKILSRTAEQKSDLISGVYEGGLKVWECTYDLLELIEKDGETFGGKAVLDLGCGAGLLGILALKRGASQVHFQDYNSTVIEQLTVPNVMLNCQEDDEVDSEDDKEGSGKGKMKEKDCSKKKAKGQKEVTENSPPPKKQAIDLAQHPLLTRCHFYSGDWSTFLALVLKADPPPKYDLIFTSETIYNTAYYPALHETLRKLLAPDGLVYLATKSHYFGVGGGLHLFETFVEQRDVFSVDHLWDGEEGLQRHVVVLRFKKSKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3U7</accession>
    <name>A0A3P9B3U7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">trypsin</fullName>
            <ecNumber evidence="11">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3U7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004447"/>
    <dbReference type="Ensembl" id="ENSMZET00005004649.1">
        <property type="protein sequence ID" value="ENSMZEP00005004447.1"/>
        <property type="gene ID" value="ENSMZEG00005003478.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244883"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000258">
        <property type="entry name" value="Anionic trypsin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000008">
        <property type="entry name" value="Cationic trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF6">
        <property type="entry name" value="TRYPSINOGEN 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0222">Digestion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018293092" description="trypsin" evidence="13">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="242" mass="26494" checksum="8495FC88B9E2B6E0" modified="2019-02-13" version="1">MRSLVFVLLIGAAFALDDDKIVGGFECTPYSEPHQVSLNSGYHFCGGSLINQNWIVSAAHCYKSRIQVRLGEHDISVNEGTEQFIDSSRVIRHPQYDSWNIDNDIMLIQLSQPASLNSYVQPVALPRSCAPAGTMCTVSGWGNTMSSTADRDRLQCLNIPILSYSDCNNSYPGMITDSMFCAGYLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCAERDHPGVYTKVCIFNDWIQQTMASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B4B1</accession>
    <name>A0A3P9B4B1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B4B1"/>
    <dbReference type="Ensembl" id="ENSMZET00005004926.1">
        <property type="protein sequence ID" value="ENSMZEP00005004721.1"/>
        <property type="gene ID" value="ENSMZEG00005003655.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183111"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF903">
        <property type="entry name" value="MEPRIN A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="14">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="13">
        <location>
            <begin position="206"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="491"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="695" mass="79337" checksum="1D1987F304BB980F" modified="2019-02-13" version="1">MSTIINENILWTSPVPYLLNNDLDINSKGVILRAFDQFRLKSCIDFKPRDSEDYYISVKQLNGCWSYIGKASRGQELSIGIGCGYIAIVEHEFLHALGFYHEQSRYDRDDYVTINSENILEAYKHNFRIVSSDESTTHGVPYDYLSVMHYGKDDFTNGNGSTIITKDPKFQNLIGQRVEMSTSDVQELNLLYKCSKCSKIMGTSIHSDHTNLPSGNGNQGKDAGYFMYASTESGQEGDSAWLETKRMSPQRECHVQCLQFYYYHNGSQTDKLNIWIREFQDEWDSTGTRYLMGQISGPPTSHWTLHHVPLNATKQFQVEFEVRKGAGNSTGGFSIDDINLSELECPDGTWQINDFERFWNSTHTPALIYSPRQYSSEGYAYRVALYLRQTDFGVYVHLVSGVYDDQLKWPCPERQFTVQMVDQNPNIQLQMSRQMSLTTDPNLLTTTGTFVHFTIDALQIKISQTLQELETLLPSPILEEVYKFVDKAQRAQHSKGKERQRRKFHTLLSKTHTPHSEPTPTQPREENTPEVSQEKWVKNFSDRNLTETEKRVIAKGLNFAISPQQLPIVDLITATESAIRINKLSQTEAEQIRMKVSATLSSAKVLPSNLTIQEKKAIASLSKDHNITVLPADKGRCTVVLNRDGYRLGFIRYRCQTGTFETVPVLKQCSNRCLKNGEHKIGPKTSHVQLVFVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B4W1</accession>
    <name>A0A3P9B4W1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum-Golgi intermediate compartment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012780538.1">
        <property type="nucleotide sequence ID" value="XM_012925084.2"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005004936"/>
    <dbReference type="Ensembl" id="ENSMZET00005005150.1">
        <property type="protein sequence ID" value="ENSMZEP00005004936.1"/>
        <property type="gene ID" value="ENSMZEG00005003745.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473800"/>
    <dbReference type="CTD" id="8729"/>
    <dbReference type="GeneTree" id="ENSGT00940000156925"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000007">
        <property type="entry name" value="Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000004">
        <property type="entry name" value="Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="17">
        <location>
            <begin position="693"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="217"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1293"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1435"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1731"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1293"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1463"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1744"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1794"/>
            <end position="1804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1871" mass="207665" checksum="06E8AACD5E0ACE0C" modified="2019-02-13" version="1">MVDKNIYIVQGEISTVVGAIKRNSRWNTHTPLDEEQDPLLNSFGNLKDILNTIKELSDVEPNIFLRPFLEVVRSEDTTGPITGLALTSVNKFLSHGLIDASHEAAAEAIENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKTAEHTLVDMVQLLFSRLPQFKEEAKSYVGANMKKLKMRAGGMSESSKWKKQKRSPRPPRHMVRSSSGQMEPSQPSTLNNNLSGGVPFMEEGLSNPSLPVSDSSASSICSPTATDSGLDTCSKTTSREDLSDLDQCSSASTAGAAIALTGTESGSTDAQFEGQQAEPAPSASVESIPEVLEDKDSITEQSDSASVHDMDYVNPRGVRFTQSTQRDGASLIPYGLPCLRELFRFLISLTNPHDRHNTDAMMHMGLQLLTVALESAHIPNYQSLLVLVKDELCRHLFQLLSVDRMNLYASSIRVCFLLFESMRVHLKFQLEMYLKKLIDIITSENIKMPYEMKEVALEALVQLWRIPSFVTELYINYDCDFYCSNLFEDLTKLLSKNAFPVSGQLYTTHLLSLEALLTVIDSIEAHCQARVLSSIAQQDQAETALADGEGAAKAETDSAADVSRLGSTNGLSPSQPEKAPVYPPTSGHLMAEKMRLGRQDQGDGDLSEKRSLKKPQRFLSCLPDSHELMEIRTKKKLLITGTEQFNQKPKKGIQFLQEKGLLSSPIDNNQVAQWLRENPRLDKKMIGEYVSDRKNPELLDSFVNTFTFQGLRIDEALRLYLEAFRLPGEAPVIQRLLETFTDNWHKVNGFPFMSNDAGFALAYAVIMLNTDQHNHNVRKQNIPMTVEQFKKNLKGVNGNKDFDQDMLEDIYNAIKNEEIVMPDEQTGLVKENYVWSVLLHRGASSEGVFLHLPPGSYDNDLFTMTWGPTIAALSYVFDKSLDDVIIQKAITGFRKCAMIAAHYGFNDVFDNLIISLCKFTTLSSESVENLPTVFGSNSKAQTAAKTVFDLAHRHGNILREGWKNIVDSLLQLFRAELLPKAMVEVEDFVEPNGKISLQREETPSNRGESAVLSVFNWLTLSGAEQSGLRGPSTENQEAKQAAVHCIKQCDPEKLITESKFLKLESLQELMKALISVTPDEETYDEEDAAFCLEMLLRIVLENRDRVSCVWQTVRDHLCQLCVHANESCFLVERAVVGLLRLAIRLLRREDISSQVLLSLRLLLMMKPHVLSRVSREVAYGLHELLKTNAANIHCTDDWYTLFSLLECIGAGVKPPVAFQLTSATADTDTGAQSDSELSSHHPSEVSLDRGYTSDSEVYTEHSKTRIPRSATDVDVASSGWLVVGKDDFEISKTPTVGSKAQLNHPLVNQYSLTLGQDLGQHDTKSLIKCVETLSFIVRDAAHVTPDNFELCVRAIRVFVEASLNGGYRNHDKKKSHKYDTSKSRMRKKAGGREKDSGGSVRRSSSRTFSQRPSRSYSDDEEDEGVPASYHTVSLQLLDLMHTLHTRAASIYNSWAEEQCHLEASSRKIEADSQTLWTSCWCPLLQGIAWLCCDARRPVRMQALTYLQRALLVHDLQTLDAIEWESCFNKVLFPLLTKLLDNISPADVGGMEETRMRACTLLSKVFLQHLSPLLSLPTFAALWLTILDFMDKYMHAGSSDLLLEAIPESLKNMLLVMDTAGIFHSADSRTGYSDLWEITWERIVCFLPLLREELFKQTIIPDAVPNPQAESVQLTTPAGRPPSPQVSPPPMQTPAQAPVNSTVAQSSSRPASPLEPPPASANGSGRSSPAPPLIPPMPVPLTTSPVQGPSPLGQSPLILQPLASPLQVGVPPMSLPIILNPALIEATSPVPLLPAPRSTTPSDEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5P8</accession>
    <name>A0A3P9B5P8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Calnexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552091.1">
        <property type="nucleotide sequence ID" value="XM_004552034.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5P8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005218"/>
    <dbReference type="Ensembl" id="ENSMZET00005005445.1">
        <property type="protein sequence ID" value="ENSMZEP00005005218.1"/>
        <property type="gene ID" value="ENSMZEG00005004048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487554"/>
    <dbReference type="KEGG" id="mze:101487554"/>
    <dbReference type="CTD" id="821"/>
    <dbReference type="GeneTree" id="ENSGT00950000182915"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048916">
        <property type="term" value="P:posterior lateral line development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000430">
        <property type="entry name" value="Si:ch211-274f20.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF11">
        <property type="entry name" value="CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="20 25" id="KW-0143">Chaperone</keyword>
    <keyword evidence="19 24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 25" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 25" id="KW-0732">Signal</keyword>
    <keyword evidence="6 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017853144" description="Calnexin" evidence="25">
        <location>
            <begin position="27"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="283"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
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</entry>
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    <accession>A0A3P9B6E8</accession>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
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                <person name="Guyon R."/>
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                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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            <location evidence="1">Perinuclear region</location>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
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        <property type="entry name" value="dsrm"/>
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        <property type="entry name" value="DSRM"/>
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        <property type="entry name" value="dsRNA-binding domain-like"/>
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        <property type="entry name" value="DS_RBD"/>
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        <location>
            <begin position="27"/>
            <end position="94"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005856"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="290" mass="31520" checksum="F231BA11ADF26790" modified="2019-02-13" version="1">MSQSPAVKSEDASLDTNESQKSNSGKTPIQILHEYGTKSGNLPVYVMERAEGEAHQPSFVFSVTVGDVSGIGQGPSKKAAKHQAAEAALKAMNIDAGVMNVPGTSDSNGVAAETNNHPNSVGLLQELALQRGWHLPEYTVLTEAGPPHKREFTVICRLESLSEKGVGNSKKAAKKVAAEKIVAKLQSLSGCSEITWGPKPSVRFENLRNSMAEKISLLRRNPLSIPNTDYIQMMLDLSNEQGFEVTYFDIGKKTNCICIFLLAILVPSTQIMWFPASLTHIRFKEKLPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B7Q1</accession>
    <name>A0A3P9B7Q1_9CICH</name>
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        <submittedName>
            <fullName evidence="8">NIPA like domain containing 3</fullName>
        </submittedName>
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    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
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    <dbReference type="RefSeq" id="XP_004540495.1">
        <property type="nucleotide sequence ID" value="XM_004540438.2"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005005875"/>
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        <property type="protein sequence ID" value="ENSMZEP00005005875.1"/>
        <property type="gene ID" value="ENSMZEG00005004549.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101477885"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EmrE-like"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF14">
        <property type="entry name" value="NIPA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="175"/>
        </location>
    </feature>
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            <end position="201"/>
        </location>
    </feature>
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    </feature>
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            <end position="383"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="383" mass="41933" checksum="0ACFDC6858181283" modified="2019-02-13" version="1">MDYNGAEIGSYTDNLIGTLLAIFGNVLVSISLTVQKYSHVKLAGTKEHRAFYRTKTWWSGFIFTCLGELANFVSYAFAPLAIVAPLNAVSVLTSSILGFIFLRERLKPKDFAKQYGLVFLGYILVIGGAYLLVSFGPNSHEKLIAANIVKHLVGWPVLLYLLLEIITFCLLLYFYKRRKANYLVIILLLVALLGSVTVLTVKAVSGMLVLTIEGTMQLNYPIFSVMFVCMVASAIFQAGFLSQACKLHDSSLVASVNYILSTFFAVLAGAVFYLEFSNEDILHICMFLLGSAVCFLGVFLITKTKKKARIFEPCVTLNMSNGVPTIHDKGPVIQPDYSGSFSYGTLVNNNGVAPAPLPVHLETPPLGPRTSDASQGHPAIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B7T0</accession>
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        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL18</fullName>
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        <alternativeName>
            <fullName evidence="8">60S ribosomal protein L5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
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                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570613.1">
        <property type="nucleotide sequence ID" value="XM_004570556.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9B7T0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005877"/>
    <dbReference type="Ensembl" id="ENSMZET00005006132.1">
        <property type="protein sequence ID" value="ENSMZEP00005005877.1"/>
        <property type="gene ID" value="ENSMZEG00005004543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468366"/>
    <dbReference type="KEGG" id="mze:101468366"/>
    <dbReference type="GeneTree" id="ENSGT00950000183210"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
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    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="10">
        <location>
            <begin position="236"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="298" mass="34148" checksum="A6180B31EE8C071C" modified="2019-02-13" version="1">MGFVKVVKNKAYFKRYEVKFRRRREGKTDYFARKRLVVQDKNKYNTPKYRMIVRFSNRDICCQIAYAKIEGDHIVCAAYSHELAKYGITVGLTNYAAAYCTGLLLARRLLQKFGMDQVYEGQVEVTGDEFNVESVDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLAIPHSLKRFPGYDTESKEFNAEVHRKHIMGMNVADYMSYLMEEDEDAYKKQFSRFIKNGVTPDMVEEMYKKAHAAIRANPIHQKKPKKDVKKKRWNRAKLSLAQRKDRVAQKKASFLRAQEQEEGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8T7</accession>
    <name>A0A3P9B8T7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lactosylceramide alpha-2,3-sialyltransferase</fullName>
            <ecNumber evidence="13">2.4.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ganglioside GM3 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">ST3Gal V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sialyltransferase 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer (LacCer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM3 (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17950"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60065"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.4.3.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:18418"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a beta-D-Gal-(1&lt;-&gt;1')-ceramide + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:82643"/>
            <dbReference type="ChEBI" id="CHEBI:143593"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ganglioside GA1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM1 (d18:1(4E)/18:0) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73110"/>
            <dbReference type="ChEBI" id="CHEBI:78484"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41785"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ganglioside GA2 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM2 (d18:1(4E)/18:0) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78485"/>
            <dbReference type="ChEBI" id="CHEBI:78486"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41777"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.9" evidence="13"/>
    <dbReference type="RefSeq" id="XP_014264064.1">
        <property type="nucleotide sequence ID" value="XM_014408578.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014264065.1">
        <property type="nucleotide sequence ID" value="XM_014408579.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8T7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006319"/>
    <dbReference type="Ensembl" id="ENSMZET00005006608.1">
        <property type="protein sequence ID" value="ENSMZEP00005006319.1"/>
        <property type="gene ID" value="ENSMZEG00005004905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486925"/>
    <dbReference type="KEGG" id="mze:101486925"/>
    <dbReference type="CTD" id="8869"/>
    <dbReference type="GeneTree" id="ENSGT00940000157929"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047291">
        <property type="term" value="F:lactosylceramide alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000006">
        <property type="entry name" value="ST3 beta-galactoside alpha-2,3-sialyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051142">
        <property type="entry name" value="Glycosyltransferase_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713:SF60">
        <property type="entry name" value="LACTOSYLCERAMIDE ALPHA-2,3-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713">
        <property type="entry name" value="SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="365" mass="41104" checksum="D887317452877BC2" modified="2019-02-13" version="1">MRLQIRWAAHRRVLAAAVVVFLGLVLVSMQLLSTGPIKPAEWVINPAHRKLVHEYVQRVLESQCRPGNTRQSLLTHLPASSHNVQPFLWKDEPLNDDLFLYPPPFGFRGLQSKVAELQKLLPASDSPQPEKAAGKCQRCLVMGNGGILKGLELGPVIDRFDTIIRLNRGPLGKFSIDVGNRTTIRMSYPEGTPLSWADTDPDTLFVTVVYKSGDISWSSAMINKLSVPLWDWFFFWQKVPDRIPLKASKFRLLNPHVIRETALDLLKYPLPRPRLWGWDQNIPTLGVSALTLASLLCDEVSLAGFGYNLSQHGAPLHYYDQLPMSAMLEQSMHNVNRETELLQRLVREGTITDLTGGIHCSYCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8Z7</accession>
    <name>A0A3P9B8Z7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_004559870.1">
        <property type="nucleotide sequence ID" value="XM_004559813.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012776950.1">
        <property type="nucleotide sequence ID" value="XM_012921496.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8Z7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006327"/>
    <dbReference type="Ensembl" id="ENSMZET00005006616.1">
        <property type="protein sequence ID" value="ENSMZEP00005006327.1"/>
        <property type="gene ID" value="ENSMZEG00005004893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473264"/>
    <dbReference type="KEGG" id="mze:101473264"/>
    <dbReference type="GeneTree" id="ENSGT00390000004215"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF16">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="393" mass="45257" checksum="DC154930EFD50250" modified="2019-02-13" version="1">MSGPVPSRARVYTEVNTHRPREYWDYESHVVEWGNQDDFQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIISLIDIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELEPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQARLTAREAMDHPYFFPIGKDQSRVTGSANLPSGNPAVSTANMITGISALPASTALGPLTGSPVLSAATNALSTPVPAAAGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9B5</accession>
    <name>A0A3P9B9B5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570591.1">
        <property type="nucleotide sequence ID" value="XM_004570534.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9B5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006457"/>
    <dbReference type="Ensembl" id="ENSMZET00005006754.1">
        <property type="protein sequence ID" value="ENSMZEP00005006457.1"/>
        <property type="gene ID" value="ENSMZEG00005004996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487438"/>
    <dbReference type="KEGG" id="mze:101487438"/>
    <dbReference type="CTD" id="51208"/>
    <dbReference type="GeneTree" id="ENSGT00940000158655"/>
    <dbReference type="OrthoDB" id="8795554at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="244" mass="26113" checksum="AB7F870B48022F5B" modified="2019-02-13" version="1">MAPSVLQNGGFILGLIGAAALIAATAMNNWSVKDRQEQVVTSVYTYKGLWQDCETTSAGLTECRPLYGLLGYSGTFQTVRALMIVGVVLSVLGMLISVFSLSCLTMNKMADSAKANMSLTAGIMFVIAGVCGIAGASVYANQIVESFRTSTYTSYTQEMMGEGMNMGMGGVGITTYTFGPALFVGWIGGGVLLIGGILKSLAFREMIKDEKPRYPGVVYKPQSNNKTEVMDHRSEGGKKEHQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAX3</accession>
    <name>A0A3P9BAX3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerebellar deration related protein 2 like</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDR2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557534.1">
        <property type="nucleotide sequence ID" value="XM_004557477.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAX3"/>
    <dbReference type="Ensembl" id="ENSMZET00005007356.1">
        <property type="protein sequence ID" value="ENSMZEP00005007049.1"/>
        <property type="gene ID" value="ENSMZEG00005005418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463657"/>
    <dbReference type="KEGG" id="mze:101463657"/>
    <dbReference type="GeneTree" id="ENSGT00390000018570"/>
    <dbReference type="OrthoDB" id="10059415at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026079">
        <property type="entry name" value="CDR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232">
        <property type="entry name" value="CENTROCORTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232:SF10">
        <property type="entry name" value="CEREBELLAR DEGENERATION-RELATED PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="493" mass="55975" checksum="54D8DFA48B23C124" modified="2019-02-13" version="1">MLSSGRMEEFITEEEEPWYDQQDLEQDLHLAAELGKTLLERNKELEDSLQQMYITNEEQVQEIEYLSKQLEVLRDMNEQHAKVYEQLDGTARELERTNHTLVMDSKSSQQKIERLTGTIETLQNQVESLSGQVEQLRSMEQLRVRREKRERRKTIHSFPCLRELCTAPRYEDEFVVGRAESFTMEAKRQPFEEENQHLREAVSALRAAVRAERSRREGVERECNLLISEFSRLQTRVQDAERCQARVRELEVELQELQQLRRARTFLLSSEDDGVALTQTVLSITPETDTFLEVEVGETGGGVREETAGGGGVGGEALPDSSPVRKSCSDTALNAIVARDASGRRRGSYALHANSVRKRGMSILREVDEQYHALLEKYEELLGKCRRHEESLCHAGVQTSRPVSRDPSMKDCAMGPIVAPPPTPTQSPSTPEAIESISKQVEAVDKRLGQNTPEYKALFKEIFSRIQKTKMDIKATKAAKTSKPGKSGKSSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BC89</accession>
    <name>A0A3P9BC89_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007381"/>
    <dbReference type="Ensembl" id="ENSMZET00005007692.1">
        <property type="protein sequence ID" value="ENSMZEP00005007381.1"/>
        <property type="gene ID" value="ENSMZEG00005005658.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164296"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="245"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="521"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1507"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1531" mass="177404" checksum="813A01FC0DC59C14" modified="2019-02-13" version="1">MKRRYCENDEFRKKQKQYVKKRFSENATVRKKQQQYIKRRYCENDEFRKKQQQYIKRRYCDNAEFRQKQKNYITKRYQENPEFRERQRSRVTQRYARDNAFRVRHRQLMKQLMRDRYQSNLAFRIMHNMRCAMKIKRKYRWVNRQTQESDNSVINEAISVFKSQIKAGPSYPCTVCFKASFPNQVRPCTRSKYVKNPHVVATCLTGRFVHVCDENCRNEQCNVPDERKREWICHTCHDHLKNGFMPALAVANKLDLADTPPELSDLNILERHLIAKCIPFAKIIPLPKGRQRAIRGNVVCVPSEVQETVEALPRLRINSQVMRVKLKRRLSYKGHQLFQTVSWSKLVQALHKLKQIHPQYKDVSIRDDAELCDPTLPDEDDEDDDDENMNEDDYDEADLMEIDSCEKNALSEAQNKNEQDIDMLPCDGEQSHEQMRDDSEQADGLTNGGFALESCLQPPDVAEEILCFSEGIYSVAPAERNNPISFFKTPKLEAMAFPVQFPTGQNTLDERRLIKVSPSGYFKSRLFCIDDRFAKDTNYLFFAQFVTEIHLATSSMTVQLRKAKPLTRDGRKITSGMLQDKHEVEKLVRNKDAVRFMQPLRGTPAYWEKTTRDLFAMIRQLGTPTFFCTFSAAEMRWPEVIEAITRQQGEQVNFEGLDWSAKCDILRSNPVTTMRMFDKRVEALFRDLLLSPAEPLGKVIDYFYRVEFQHRGSPHIHCLLWVEGAPVFEEDDEQTVLDFINKYITAQLPDPHKQPELYKKVTEVQKHSKNHTKTCFRSLSSGCRFGFPKPPCNETMITRPSEDDALEVETAKNKLRPLNQLLNEPETASMSLEQLLERCKLTHAEYERYLNKMNMRSTIILKRDPKDSWINGYNPHLLEAWNSNIDISFVLDAFGAANYLMKYISKKEGGLSEYLKTVIENSHKDSVNECDEMRAVMQAYSKKREISAQECVARACGLHMKQCSRAVIFIPTDDNPVKMSRPLSVLDNTTPESSNVWMTSLNDKYKARPETPEYEEMCMADFAATCRIVYGQQKKGKDVLPLLNEMGFVQRRKNNKPAIIRFHRCSQEKHPEQYYGRLLKLYLPHRSDHELKTPSLPSYQAFYGAGCVQLPGTDHLEYVQHIVKRNREKYEKNSEEIESAVEEYEQNRGVTDEWCNLAPESDLVRLPLVEQERERDNENEQEDVPDYSRQADASTEVRAIREPPAIDPTLLRQMFQNLNKKQACIFYAVRDWCIKRVCALNPEQFFFYINGGAGTGKSHLIKCIYSEASKILSKVPRYADDVDISKPTVLLTAFTGTAAFNISGTTLHSLLKLPRSLKPPIQGLGNQLDEVRSELLNAEIIVIDEVSMVSRHLFAYVDARLKQIKGTRRPFGGMSVIAVGDFYQLPPVRQSKPLCVHDPSEIDLWREHFQMITLTEIMRQKDDVVFAEMLNRIRVKGKLDELCEADRDLLLQAITEPAHCPTDALHIFATNKEVDAHNSSTLALLHTHIIDIHADDYRKDPRTGRMALQDRPLKGGKNELPDTLKVAEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD03</accession>
    <name>A0A3P9BD03_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-binding protein inhibitor ID-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Inhibitor of DNA binding 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Inhibitor of differentiation 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterodimer with other HLH proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004540552.1">
        <property type="nucleotide sequence ID" value="XM_004540495.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD03"/>
    <dbReference type="SMR" id="A0A3P9BD03"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007646"/>
    <dbReference type="Ensembl" id="ENSMZET00005007964.1">
        <property type="protein sequence ID" value="ENSMZEP00005007646.1"/>
        <property type="gene ID" value="ENSMZEG00005005852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469221"/>
    <dbReference type="KEGG" id="mze:101469221"/>
    <dbReference type="CTD" id="266599"/>
    <dbReference type="GeneTree" id="ENSGT00940000156464"/>
    <dbReference type="OrthoDB" id="10047910at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043697">
        <property type="term" value="P:cell dedifferentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070365">
        <property type="term" value="P:hepatocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046532">
        <property type="term" value="P:regulation of photoreceptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902866">
        <property type="term" value="P:regulation of retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000048">
        <property type="entry name" value="DNA-binding protein inhibitor ID-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026052">
        <property type="entry name" value="DNA-bd_prot-inh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723:SF5">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR ID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="14">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="136" mass="15189" checksum="C96AE4E799A33B54" modified="2019-02-13" version="1">MKAISPVRSFRKNSVNLSEHSLGISRSKTPVDDPLSLLYNMNDCYSKLKELVPSIPQNKNVSKMEILQHVIDYILDLQIALDSSVALTSLHHPSRPGQTPSRTPLTTLNTDISILSLQSPELPSELMTDDSRTLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD04</accession>
    <name>A0A3P9BD04_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="RefSeq" id="XP_004548339.1">
        <property type="nucleotide sequence ID" value="XM_004548282.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD04"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007800"/>
    <dbReference type="Ensembl" id="ENSMZET00005008118.1">
        <property type="protein sequence ID" value="ENSMZEP00005007800.1"/>
        <property type="gene ID" value="ENSMZEG00005005938.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484317"/>
    <dbReference type="KEGG" id="mze:101484317"/>
    <dbReference type="CTD" id="564110"/>
    <dbReference type="GeneTree" id="ENSGT00940000155867"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF47">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="10">
        <location>
            <begin position="228"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="405" mass="46307" checksum="9E8D264ED1A6BC86" modified="2019-02-13" version="1">MGLRHSSRCLLLRRKMAEADSSERQQPVMSPISQSAQPSPLPKPVPTTHHVPCVPHTPHVAALATCPGRGKIAKFISPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNAMYHNKHVFKDKIVLDVGSGTGILSMFAANAGAKHVYGIECSSISEYSEKIIKSNHLHNVITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMSCIRNVAIKEPLVDVVDPKQVVTNACLLKEVDIYTVKPEDLSFTSAFCLQIQRNDYVHALVTYFTIEFTKCHKKTGFSTAPDAPSTHWKQTVFYLEDYLTVKKGEEIFGSLAVRPNEKNVRDLEFTLELDFKGQLCEAAISHDYKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFY9</accession>
    <name>A0A3P9BFY9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Y+L amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570556.1">
        <property type="nucleotide sequence ID" value="XM_004570499.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BFY9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008807"/>
    <dbReference type="Ensembl" id="ENSMZET00005009147.1">
        <property type="protein sequence ID" value="ENSMZEP00005008807.1"/>
        <property type="gene ID" value="ENSMZEG00005006687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477919"/>
    <dbReference type="KEGG" id="mze:101477919"/>
    <dbReference type="GeneTree" id="ENSGT00940000164654"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF213">
        <property type="entry name" value="Y+L AMINO ACID TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="514" mass="56618" checksum="513FC77E0211ADC9" modified="2019-02-13" version="1">MGDLRQTIGVMSQTICPSSRVPSEEDLKAPNGVKEEKMQMKREISLLNGICLIVGNMIGSGIFVSPKGVLMYSASYGLSLLIWALGGIFSVFGALCYAELGTTITKSGASYAYILESFGGFLAFIRLWTSILLIEPASQAVISLTFANYLVEAFYPTCQPPYAAVRLLAAACLCILIFINCAYVKWGTLVQDIFTYAKLMSLFLIIIIGILKISSGETKSFENPMEGSTADPGAIALALYSALFSYSGWDTLNYVTEEICNPERNLPLAIAISMPIVTIIYLLTNVAYYVVLDMSSLLASDAVAVTFGNAVLGPFSWIIPVSVAMSCYGGLNASVIAASRLFFVGAREGHLPNSLSLIHLKRYTPIPALLFNGLMGLIFLCVRDVFQLINYFSFSYWLYVGLSVAGLIYLRITQPERYRPVKLTLFFPFIYCFCSLFLVIVPLYGDTINSLIGIGIALSGVPVYYVAIYLPEERRPKFIRKLNTFATRYTQMLLYCCMTESDTEEEIHGGIKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHR6</accession>
    <name>A0A3P9BHR6_9CICH</name>
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        <recommendedName>
            <fullName evidence="5">Ceramide transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Collagen type IV alpha-3-binding protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)</text>
            <dbReference type="Rhea" id="RHEA:45720"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_004566935.1">
        <property type="nucleotide sequence ID" value="XM_004566878.1"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005009281"/>
    <dbReference type="Ensembl" id="ENSMZET00005009631.1">
        <property type="protein sequence ID" value="ENSMZEP00005009281.1"/>
        <property type="gene ID" value="ENSMZEG00005007008.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484839"/>
    <dbReference type="KEGG" id="mze:101484839"/>
    <dbReference type="GeneTree" id="ENSGT00940000155123"/>
    <dbReference type="OrthoDB" id="2344588at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="collagen type IV alpha-3-binding protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagen type IV alpha-3-binding protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
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        <property type="entry name" value="STARD11_START"/>
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        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF53">
        <property type="entry name" value="CERAMIDE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="15">
        <location>
            <begin position="416"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSMZEP00005009281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="625" mass="71157" checksum="AFD912CD00161BB2" modified="2019-02-13" version="1">MSDNQSWNSSGSEEDIEPREEPGHPIGIAEFSGYLSKWTNYIHGWQDRWVVLKNNTLSYYKSQDETEYGCRGSLCLSKAVITPHEFDECRLDMSVNDSVWYLRAQDPEHRHQWIESIELHRSIREGRREKGGVQGRIIIPPPLADSGYGSESSLRRHGSMLSLTSATSGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDSCADAVSKDELQRDKIVEDDEDDFPNTRTDGEFLHNNNGSKEKSLQSLNPKGINGIDFKGEAITFKATTAGILATLSHCIDLMVKREDSWQKRLDKEMEKRRRIEESYKSALNELKKKSHFGGPDYEEGPNSLINEDEFFDAVEAALDRQDKIEEQSQTEKTRIQRSDAVSLGDAYSSSGTHRFSNKVEEMVQSHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHSVKGVTGHEVCHYFWDTAYRSDWETTIENFNVVETLSENAVIVYQTHKRVWPASQRDVLYLSAMRKIMASNENDPDTWLVCNFSVDHENALPTSRCVRAKINIAMICQTLVSPPDGDKEISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIH0</accession>
    <name>A0A3P9BIH0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">UF2 component of NDC80 kinetochore complex</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014264180.1">
        <property type="nucleotide sequence ID" value="XM_014408694.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIH0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009729"/>
    <dbReference type="Ensembl" id="ENSMZET00005010089.1">
        <property type="protein sequence ID" value="ENSMZEP00005009729.1"/>
        <property type="gene ID" value="ENSMZEG00005007350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479920"/>
    <dbReference type="KEGG" id="mze:101479920"/>
    <dbReference type="CTD" id="83540"/>
    <dbReference type="GeneTree" id="ENSGT00390000004199"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000007">
        <property type="entry name" value="NDC80 kinetochore complex component NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="215"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="454" mass="52950" checksum="A551BE3C0427718F" modified="2019-02-13" version="1">MAENTFPVYSADAIVNFYRTEVLTGQEAKHFTKSDLTPHPKPEAVQTLYMRVLHLLYRFRPECHSMVPLLENIQYPAYHEGATAIMSVYTRMRQFLPMCLVYDFSLNDLLAPKKQRTLTILSAIMNFLHFRKQRMEVVLEKQTKFRADMDRLQAYTKGIREAEKKIEMLTTIPPEQQAEADELAAALSELQATTMHEYQEVNVKNDSITEWKATIAEKTQKLAQVKLDVSNLKEDISKLKSQIVESPEELKSQMEKMRENVKNMKNSIEETDERVVELQNMVQGVTHTEAEIQQMCSLLQDLESSMSNTKQRLEEHQELMAQYEKKQKELKNLCMEEGQLKRALGMKQDKECKQNIRRQKKREMKEQHVQEVLGQCDQIHQKREDMADKIQEISAETQKLKTSIKSLRDVCSKETEKAQALYDTLSTSMDELHKRIEMHTMDLKLSLTKMSANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ63</accession>
    <name>A0A3P9BJ63_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Aquaporin-4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="19">Homotetramer. The tetramers can form oligomeric arrays in membranes. The size of the oligomers differs between tissues and is smaller in skeletal muscle than in brain. Interaction between AQP4 oligomeric arrays in close-by cells can contribute to cell-cell adhesion. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Basolateral cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562341.2">
        <property type="nucleotide sequence ID" value="XM_004562284.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ63"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009937"/>
    <dbReference type="Ensembl" id="ENSMZET00005010303.1">
        <property type="protein sequence ID" value="ENSMZEP00005009937.1"/>
        <property type="gene ID" value="ENSMZEG00005007537.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101468427"/>
    <dbReference type="GeneTree" id="ENSGT00940000159304"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000019">
        <property type="entry name" value="AQuaPorin or aquaglyceroporin related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023277">
        <property type="entry name" value="Aquaporin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF34">
        <property type="entry name" value="AQUAPORIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02020">
        <property type="entry name" value="AQUAPORIN8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="260" mass="27242" checksum="CCC12FBFCB2B598A" modified="2019-02-13" version="1">MSGLESKTEVFTVTEMGEPKVEKDIGNRSKIRCKYELYVQPCLAELLGTCLFVFVGCASVIGNVETGVIQPAVGHGLALGVLITVFGQISGGHFNPAVSLSVYLCGGMKLILLVPYIVAQMAGGVVGAFLSKAVYPSNNYTASLGGAFKVVSADAGRSTLVEMLLTLILTMVVCLGAVNRRTQTDGVPFCIGLTVAANILAGGTLSGACMNPARAFGPAMAANHWDNHWVFWVGPVAGALLTVSIIRLLIGDHKTRVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BP49</accession>
    <name>A0A3P9BP49_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small ArfGAP 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004538970.4"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMZET00005011796.1">
        <property type="protein sequence ID" value="ENSMZEP00005011401.1"/>
        <property type="gene ID" value="ENSMZEG00005008548.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101475774"/>
    <dbReference type="CTD" id="60682"/>
    <dbReference type="GeneTree" id="ENSGT00940000155884"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of clathrin-dependent endocytosis"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arf GTPase activating protein"/>
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    </dbReference>
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        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
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        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF8">
        <property type="entry name" value="STROMAL MEMBRANE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="456" mass="48450" checksum="6D37EA6ABD7DEEAA" modified="2019-02-13" version="1">MATRSEREKAQKLNEQHQAILSKMLREEDNKYCADCEAKGPRWASWNLGVFICIRCAGIHRNLGVHISRVKSVNLDQWTTEQIQSIQDMGNTKARRLYEANLPDSFRRPQTDQAVEFFIRDKYEKKKYYSKNVTNGTSPKDGKKEREPDRGSKVSSYTKSEESKPVPKISPAKTAEPSVNLLGLDAPAAASANNGSTSTSQNNDLDIFGPMVSNPLPSSTSTAQFSQVSSNNSASTPTQAPAPGVSGGVANSGSLQGDLDLFSESSSTTKADDAAKKPLSKDSILSLYGTNSMSQQPPTAGMFMGPSQMQFPVQAAAGYQAFPGMGTAMPPTTVMGAMMAQSGAPMMGPSPGMMVGMTMPNGFMGNAQATGMMGMAPRMMGPQGGAMPTGMMPAQGMYAIQPGQQAQWNMGQVNQQMSGLTLNGAGGQMAFGQPPSAMGGWAPTGSGQTLSTQLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BPS5</accession>
    <name>A0A3P9BPS5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MAD2L1 binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004559837.1">
        <property type="nucleotide sequence ID" value="XM_004559780.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BPS5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011631"/>
    <dbReference type="Ensembl" id="ENSMZET00005012037.1">
        <property type="protein sequence ID" value="ENSMZEP00005011631.1"/>
        <property type="gene ID" value="ENSMZEG00005008739.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464247"/>
    <dbReference type="KEGG" id="mze:101464247"/>
    <dbReference type="CTD" id="9587"/>
    <dbReference type="GeneTree" id="ENSGT00390000003812"/>
    <dbReference type="OrthoDB" id="6334764at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009511">
        <property type="entry name" value="MAD1/Cdc20-bound-Mad2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681:SF1">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06581">
        <property type="entry name" value="p31comet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="385" mass="43264" checksum="E54ED2F3DF6E679E" modified="2019-02-13" version="1">MAEDSSILKIISNSEDTENVSTDKSRDLGIKRRLSFSSEKDISIAEAPKTPPEVQAVSEDPNSSRVSPEISKQRSPSPVNTHLKGKNAVKLKDDSSRQHCVNDTDDKENTAIPADQNNTEEDNASCQGGFKHIKVTASIQSDAEDRDAEVVRRAQEEGCVNVVFPGTVTQEGCCRFVSEILKCILYQRQQLPMTYDQLVYSQRKQQASVQDKDVVNRRPVHSADMDWRKCQQTLQELEEVLQHLEVLFSLSRVPRVLLLMGGSLVLPKELYEINMESLASSGGNLCLRVSSCLRQIFRTLFVADLLSDTRPVRLMPTTVLVLAHRDCGVGWFRPKLQFKVPTRVKKQIIVLSSDPNVCKEPRAEGSDWEDYVWFQAPVTIKGFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSH6</accession>
    <name>A0A3P9BSH6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Membrane-associated progesterone receptor component 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Mitochondrion outer membrane</location>
            <topology evidence="18">Single-pass membrane protein</topology>
            <orientation evidence="18">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSH6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012869"/>
    <dbReference type="Ensembl" id="ENSMZET00005013315.1">
        <property type="protein sequence ID" value="ENSMZEP00005012869.1"/>
        <property type="gene ID" value="ENSMZEG00005009668.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160619"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036438">
        <property type="term" value="P:maintenance of lens transparency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030728">
        <property type="term" value="P:ovulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903538">
        <property type="term" value="P:regulation of meiotic cell cycle process involved in oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032570">
        <property type="term" value="P:response to progesterone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF23">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="68"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="187" mass="21216" checksum="5621CD993B52AED6" modified="2019-02-13" version="1">KEANDLYKTAESSELTSGGIFQEIFTSPLNLTLLSLCFFLLYKIFRGDKPPELSEEDKPLPKMKKRDFTLAELKPYDGLQNPRILMAINGKVFDVTRGKKFYGPDGPYGVFAGRDASRGLATFCLDKEGLKDEHDDLSDLNSMQKESLSDWESQFTMKYDYIGKLLKPGEEPTEYTDDEEGKNKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSQ1</accession>
    <name>A0A3P9BSQ1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
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                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
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                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
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                <person name="Ron M."/>
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                <person name="Tan F.J."/>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
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                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Noh H.J."/>
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                <person name="Aken B."/>
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                <person name="Amemiya C."/>
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                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="Streelman J.T."/>
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            <authorList>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTG6</accession>
    <name>A0A3P9BTG6_9CICH</name>
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        <recommendedName>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <end position="90"/>
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            <end position="180"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21186" checksum="33E3BE315834AAA1" modified="2019-02-13" version="1">PASSFLKLLEMLEDLKKEELEKFKWFLRDRDVLVELQPISESKLEKASTCDLVDLVVQTYTEKSVEVTKKVFRKINRNDLVQKLSDTASRKVLENVSLFHPKMELIQRVSNIEPILDELLKEKVIQQESYDRIRALQTSQEKMRELYSGPLKAGSASKDVFYQILQTHERLLLNDLYDAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTR5</accession>
    <name>A0A3P9BTR5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTR5"/>
    <dbReference type="Ensembl" id="ENSMZET00005013740.1">
        <property type="protein sequence ID" value="ENSMZEP00005013289.1"/>
        <property type="gene ID" value="ENSMZEG00005009992.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182774"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018231485" description="C2H2-type domain-containing protein" evidence="12">
        <location>
            <begin position="23"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="323" mass="36992" checksum="06EBB2936AEACBD2" modified="2019-02-13" version="1">MADLNKILLLLILLSSGVPSEAGHNTPKKNFSCSACGKHFVYKQSLKRHIRRNSENGSSGCLDNMKCFKRKQSIDSHIKIYTGEKPFGCGFCGKRVKYLYNLKSHMRVHTGEKLFGCDICGKRFTHHQNLKTHVTIHSGEKPFVCDICGKRARHQNNLKIHMIAHTGEKPFGCDDCGKRFKRKTHLTTHMTVHTAEKPFGCDVCGKRFNRKSHLRTHMIVHTGEKPYGCDVCGKKFNRKTHLESHITVHTGEKPFGCAICDQGFTQQGSLNRHMRFHLGHQESIFTQRAQRRERQQVILNMFTYLSILSHNHVINSLDICERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BUQ1</accession>
    <name>A0A3P9BUQ1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BUQ1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013678"/>
    <dbReference type="Ensembl" id="ENSMZET00005014146.1">
        <property type="protein sequence ID" value="ENSMZEP00005013678.1"/>
        <property type="gene ID" value="ENSMZEG00005010293.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176994"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="154" mass="17738" checksum="A001825B9C283BC1" modified="2019-02-13" version="1">QLKSSLEGVRMTADGIFIIDESSPTENTSDLSCSVRALQQDLDELKSVNESLRKENHNLREQLNTARNRPSCDAEFARALKVFYHSMTSVRGQLQRLRRHRPSESDLLGLRLFVDEQSHLLRDFSEQLEQNVSTLKQDVAAIVRRKRERSGIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVJ1</accession>
    <name>A0A3P9BVJ1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tumor necrosis factor, alpha-induced protein 8-like 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560216.1">
        <property type="nucleotide sequence ID" value="XM_004560159.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVJ1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013932"/>
    <dbReference type="Ensembl" id="ENSMZET00005014403.1">
        <property type="protein sequence ID" value="ENSMZEP00005013932.1"/>
        <property type="gene ID" value="ENSMZEG00005010501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464250"/>
    <dbReference type="KEGG" id="mze:101464250"/>
    <dbReference type="CTD" id="393345"/>
    <dbReference type="GeneTree" id="ENSGT00390000003488"/>
    <dbReference type="OrthoDB" id="10055976at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.160:FF:000001">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.160">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008477">
        <property type="entry name" value="TNFAIP8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038355">
        <property type="entry name" value="TNFAIP8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757:SF4">
        <property type="entry name" value="TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 8-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12757">
        <property type="entry name" value="TUMOR NECROSIS FACTOR INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05527">
        <property type="entry name" value="TNFAIP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="186" mass="21139" checksum="39B519F5906911F6" modified="2019-02-13" version="1">MDAFNAKDMAMKAQKKILSSMATKSSVQMFIDDTTSEILDELYRVSRDYLGNKSEAQKVIKDLIKIAVKIGVLFRNNRFSTEELAVAQDFKKKLHQGAMTAISFYEVDFTFEKTVMADILTSCRDLLLKLVNTHLTTKSHGRINHVFNHYSDPQLLTQLYNPDGPFRPNLTKICKGLNKLVEDGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BW84</accession>
    <name>A0A3P9BW84_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_004539559.1">
        <property type="nucleotide sequence ID" value="XM_004539502.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BW84"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013906"/>
    <dbReference type="Ensembl" id="ENSMZET00005014377.1">
        <property type="protein sequence ID" value="ENSMZEP00005013906.1"/>
        <property type="gene ID" value="ENSMZEG00005010491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477317"/>
    <dbReference type="KEGG" id="mze:101477317"/>
    <dbReference type="CTD" id="64216"/>
    <dbReference type="GeneTree" id="ENSGT00950000183142"/>
    <dbReference type="OrthoDB" id="9895503at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF13">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="14">
        <location>
            <begin position="135"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="453" mass="50737" checksum="DB8DD62697D539B0" modified="2019-02-13" version="1">MSTQICRVVELLLRSACCHTVRGQSCLSKAVWTPVGPSSLCASGVSVLQRRAYSLDSLSLGPGRPSLGPNSQQPRSERTSPSSALAHRNLSAVAVQGQCRPLCQYDFLDLGEVEENVRRAQGCKKIRHFIVDPDLANLVAQHLGPDLQDAKTVIFECNPGPGVLTRTLLNAGAQRVVALEGDRSFLHDLQELEGRLDGQLEVVHCDYFKLDPIGLGNVKPPAMFTDKLFTDLGISESAWTDDIPVKVVGILPQRNERGMLLKMVYALFERLSVYRYGRIELNLFVSEKEYLKLVARPGEMMYYRAFGVLWQMACEIELLHKVPWESFVVSSKQGVPSSKGKLPNNHLCLVRLRPRADLFSAGLTPSNASTLLMMIKQCLAKRKVKLIDRLNLWSPDSGSKLLSEMGMSEDILTGHVFPEEYLRLFQLMDKSQEFTQSWLYEEILENTQREGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWB5</accession>
    <name>A0A3P9BWB5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EPS8 signaling adaptor L1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004573758.2">
        <property type="nucleotide sequence ID" value="XM_004573701.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWB5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014179"/>
    <dbReference type="Ensembl" id="ENSMZET00005014655.1">
        <property type="protein sequence ID" value="ENSMZEP00005014179.1"/>
        <property type="gene ID" value="ENSMZEG00005010685.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483470"/>
    <dbReference type="KEGG" id="mze:101483470"/>
    <dbReference type="CTD" id="503735"/>
    <dbReference type="GeneTree" id="ENSGT00940000158125"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900029">
        <property type="term" value="P:positive regulation of ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09540">
        <property type="entry name" value="SAM_EPS8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11764">
        <property type="entry name" value="SH3_Eps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000071">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035462">
        <property type="entry name" value="Eps8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF19">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="279"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="498" mass="55134" checksum="4D1228F4828F1C75" modified="2019-02-13" version="1">MSTSLPSVLPRKPSGVRVMVLKGQQELSDGVPNKSGKENGTSGESNQIPPLNADREVEIMNHCFDDVERFMSRLQQAAEAQTVLNQRKKKNERKTKKDKKTQEDGLLTMKASPPPEEDFVNIFQKIKYSFSLLDRLKSYISQPNAPELLHHIFVPLRLMVNTTGGPALAASIISPALTNGAVKLLQEHLTLEENELWTSLGTSWTSPSSHLGVTVPPYTPVFLDGWKPQTHDSTGQPFEDPIELQHKVDAFNETKQKQSQQEEAQQAAQSPRDGNGHAHGESHYRCSYDFVARNSSELSVLKGETLEVIDSSKRWWKCRNSYGEIGFVPFNILEPVSALNKMEKDGSVVHRESQAGPVPHSKRFSYTPSSGGPTTATPAVRPQSMVLPSTRMQGDEPDRVLIMNDELLQRIARRRGSFKQTADNSTPLNYGSPSSEVAAWLTAKGFSAVTVESLGILNGAQLFSLNKEEFVAVAPEEGENVYSQIMAEKTLLKNAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWW9</accession>
    <name>A0A3P9BWW9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Actinin, alpha 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539984.1">
        <property type="nucleotide sequence ID" value="XM_004539927.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWW9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014141"/>
    <dbReference type="Ensembl" id="ENSMZET00005014617.1">
        <property type="protein sequence ID" value="ENSMZEP00005014141.1"/>
        <property type="gene ID" value="ENSMZEG00005010630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469024"/>
    <dbReference type="KEGG" id="mze:101469024"/>
    <dbReference type="CTD" id="87"/>
    <dbReference type="GeneTree" id="ENSGT00940000155548"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000005">
        <property type="entry name" value="Actinin alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000018">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000002">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000003">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="32"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="145"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="747"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="788"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="893" mass="103168" checksum="EBD26AC4272A74D1" modified="2019-02-13" version="1">MYNMEHYDEENYYMQQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRMPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGNLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTEGKEDMLQKRDYETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRICDQWDALGGLTQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLSTAHEQFKATLPEADKERLAILGIHNEIAKIVQTYHVNIAGTNPYTTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQANVIGPWIQTKMEEIGRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISLGFDIANDAQGENEFSRIMSIVDPNRMGLVTFQAFIDFMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMAPYTGPDGVPGALDYMSFSTALYGESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BX36</accession>
    <name>A0A3P9BX36_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573778.1">
        <property type="nucleotide sequence ID" value="XM_004573721.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BX36"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014454"/>
    <dbReference type="Ensembl" id="ENSMZET00005014936.1">
        <property type="protein sequence ID" value="ENSMZEP00005014454.1"/>
        <property type="gene ID" value="ENSMZEG00005010875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464214"/>
    <dbReference type="KEGG" id="mze:101464214"/>
    <dbReference type="CTD" id="8834"/>
    <dbReference type="GeneTree" id="ENSGT00390000006617"/>
    <dbReference type="OrthoDB" id="9970856at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099">
        <property type="entry name" value="PROTEIN PM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="187" mass="20970" checksum="B20DF07463CB430B" modified="2019-02-13" version="1">MASLGRRRGVPVSRERGVMAASDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLSGAACLLTPLSLPVEYLRYVALPAGALSVACAALYGISWQFDPCCKYQVEYDSQKLSRLPLHTLTSSTPVVLVRRDDIHRKRLHNTIALAALAYCAKKIYELYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXN6</accession>
    <name>A0A3P9BXN6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutathione peroxidase family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A3P9BXN6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014396"/>
    <dbReference type="Ensembl" id="ENSMZET00005014876.1">
        <property type="protein sequence ID" value="ENSMZEP00005014396.1"/>
        <property type="gene ID" value="ENSMZEG00005010823.1"/>
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    <dbReference type="GeneTree" id="ENSGT00980000198641"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047066">
        <property type="term" value="F:phospholipid-hydroperoxide glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF130">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
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    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5018036923" description="Glutathione peroxidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="183" mass="20695" checksum="11B2216C0CD441A4" modified="2019-02-13" version="1">MRLIGCTVLLSVLLSAMSTPLEEWQRATSIYNFSATDIDGNVVSLEKYGNVVIITNVASKGKTPVNYSQFTQLHAKYAERGLSILAFPSNQFGNQEPGNETQIRQFADTFQARFDMFSKIEVNGQNAHPLWKWLKEQPNGKGLFGSIKWNFTKFLINREGQVVKRYGPLDDPSVVEKDLPKYL</sequence>
</entry>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="common">zebra mbuna</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0N5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015436"/>
    <dbReference type="Ensembl" id="ENSMZET00005015934.1">
        <property type="protein sequence ID" value="ENSMZEP00005015436.1"/>
        <property type="gene ID" value="ENSMZEG00005011597.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176953"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018058743" evidence="2">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="119" mass="12893" checksum="156E3DBAEF960E09" modified="2019-02-13" version="1">FLLILCLLICVSLTAVYKFMRCNPDGDQANCVTQQSPEMEWNPDLPSKLPASAEAEEEESKLSESPGIFLGEEGSGGYEGSAAEGPYMADKSNLGETGSGMLWKESEGIFCRTGFAWIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0Y8</accession>
    <name>A0A3P9C0Y8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polypeptide N-acetylgalactosaminyltransferase</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.41" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0Y8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015546"/>
    <dbReference type="Ensembl" id="ENSMZET00005016047.1">
        <property type="protein sequence ID" value="ENSMZEP00005015546.1"/>
        <property type="gene ID" value="ENSMZEG00005011661.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158846"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000020">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF3">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0430">Lectin</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="20">
        <location>
            <begin position="130"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="494" mass="56217" checksum="632C58EEC7636F7C" modified="2019-02-13" version="1">MRRIRANAIAILTVAWILGTFYYLWQDNKPQSSPSSSASQTRGRGHGQKVIPGRLEIHRDDRTIPLILLGSFDEKAYLAAKQLKPGDDPYKDHAFNLQESDRLGSERAIRDTRHYRCAALTYDTDLPSTSIVITFHNEARSTLLRTIKSVLMRSPPSLIQEIILIDDFSSDPEDCQLLTQIPKVRCLRNGRREGLIRSRVRGANTASASILTFLDSHCEVNTDWLQPMIQRVKEDHTRVVSPIIDVISLDNFAYLAASADLRGGFDWSLHFKWEQIPIEQKMARSDPTQAIRTPVIAGGIFVMDRSWFNHLGQYDTHMDIWGGENFELSFRVWLCGGSLEILPCSRVGHVFRKRHPYDFPEGNALTYIKNTRRAAEVWMDEYKQYYYSARPSAQGKAFGSITDRLALRRKLNCKPFRWYMENVYPELSVLKQGGLCLETRGTDGLGLAECRGLGANRPQSQVRTLPLEGDLLWLTVIVRNTSDSVLHTLIFGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C1I8</accession>
    <name>A0A3P9C1I8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial amidoxime-reducing component 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540079.1">
        <property type="nucleotide sequence ID" value="XM_004540022.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C1I8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015977"/>
    <dbReference type="Ensembl" id="ENSMZET00005016488.1">
        <property type="protein sequence ID" value="ENSMZEP00005015977.1"/>
        <property type="gene ID" value="ENSMZEG00005012000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468829"/>
    <dbReference type="KEGG" id="mze:101468829"/>
    <dbReference type="CTD" id="378742"/>
    <dbReference type="GeneTree" id="ENSGT00940000159665"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="170"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="329" mass="36968" checksum="7FB28EBC0F792856" modified="2019-02-13" version="1">MDLRKLAADAVSQNKKAALLIGGAGFAILGLGLGYKYLRKPEKAVRVGVVSQLLIHPLKSGKAVPLALAECQKMGLKFGELQDRHWMVVTEDGHMVTGRQEPRLVLVSLTCEGGQVCLNGPNMEELKFPIKQPDNPVLDCRVFGVDIQGRDCGDKVSHWLTHYLKAEKTYRLVHFEPCMRPRKPAEKEAVYQQFEEVAYPDFGPVMLLSEASVKDLSSKLEKGVTVERFRPNIVISDCKPFDEDSWEELQIGSVRLQRVMACGRCLFTTVDPETGVISRKEPLETLKNYRLCKPSEKHIYKTSPLFGQLHNVKKTGIFQVGDVVYKITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3U0</accession>
    <name>A0A3P9C3U0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004563168.1">
        <property type="nucleotide sequence ID" value="XM_004563111.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3U0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016933"/>
    <dbReference type="Ensembl" id="ENSMZET00005017473.1">
        <property type="protein sequence ID" value="ENSMZEP00005016933.1"/>
        <property type="gene ID" value="ENSMZEG00005012717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474244"/>
    <dbReference type="KEGG" id="mze:101474244"/>
    <dbReference type="GeneTree" id="ENSGT00940000159677"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000176">
        <property type="entry name" value="UDP glucuronosyltransferase 1 family, polypeptide A7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF161">
        <property type="entry name" value="UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017851193" description="UDP-glucuronosyltransferase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="527" mass="59592" checksum="54DC463FE605F7C4" modified="2019-02-13" version="1">MSNGVWFPTLGLLAMLCCFSMGPVQGGKVLVVPVDGSHWLSMKILVKELIRRGHEVVVLVPESSLLIQGSESFRTEIYKVPYTKAELDGSFNIFQNEVFLKPAEFEDLIVNLRGLVNFTSLQVKGCESLLDNKPLMNRLREQGFDLVLTDPFLPCGSVLAHMFSIPAVYFLRGLPCELDMKANKCPSPPSYVPVFFSGNRNSMTFPERVKNFVMYGVQSYICTILYPHFDDLVSRYIGEISTYQELVSHGAIWLLRYDFTFEWPRPLMPNMVLIGGINCAKRAPLPADLEDFVNGSGDDGFIVFSMGSVVSTMPEEKAKHFLDAFRKIPQRVVWRYTGALPDDIPKNVRVMKWLPQNDLLAHAKAKVFITHGGSHGIYEGICNGVPMLMFPLFGDQGDNVNRLLGRGAALKLSIYDVTTEQLLGALKKLIYDKRYKAKMMELSAIHLDRPTEPVDLAAFWTEFVMRHKGASHLRVGAHDLNWFQYHSLDVLSFFAVILITVVWMTVKCCRFCIRKCCRKGTAKRKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3V9</accession>
    <name>A0A3P9C3V9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 9">Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564786.1">
        <property type="nucleotide sequence ID" value="XM_004564729.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3V9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016729"/>
    <dbReference type="Ensembl" id="ENSMZET00005017264.1">
        <property type="protein sequence ID" value="ENSMZEP00005016729.1"/>
        <property type="gene ID" value="ENSMZEG00005012565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466567"/>
    <dbReference type="KEGG" id="mze:101466567"/>
    <dbReference type="CTD" id="5888"/>
    <dbReference type="GeneTree" id="ENSGT00940000156157"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071425">
        <property type="term" value="P:hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046686">
        <property type="term" value="P:response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051597">
        <property type="term" value="P:response to methylmercury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="95"/>
            <end position="266"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="22"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056736"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="336" mass="36621" checksum="087A47B4CD4223AC" modified="2019-02-13" version="1">MAMRSEARVEVEEEENYGPQPLSRLEQCGISASDIKKLEDAGFHTIEAVAYAPKKELLNIKGISEAKADKILTEAAKLVPMGFTTATEFHQRRAEIIQISTGSKELDKLLQGGIETGSITEMFGEFRTGKTQLCHTLAVTCQLPIDQGGGEGKAMYIDTEGTFRPERLLAVAERYGLVGSDVLDNVAYARAFNTDHQTQLLYQASAMMAESRYALLIVDSATALYRTDYSGRGELSARQGHLGRFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFSADPKKPIGGNILAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4R0</accession>
    <name>A0A3P9C4R0_9CICH</name>
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        <recommendedName>
            <fullName evidence="11">Syntaxin-7</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="9">May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Early endosome membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="1 12">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004542115.1">
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    <dbReference type="Ensembl" id="ENSMZET00005017815.1">
        <property type="protein sequence ID" value="ENSMZEP00005017268.1"/>
        <property type="gene ID" value="ENSMZEG00005012980.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101466674"/>
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    <dbReference type="GeneTree" id="ENSGT01000000214440"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:synaptic vesicle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:SNAP receptor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:SNARE binding"/>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:vesicle docking"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
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    </dbReference>
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        <property type="entry name" value="SYNTAXIN-7"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="258" mass="28686" checksum="961D611FB4D5FCC8" modified="2019-02-13" version="1">MAYQAGIPEEPSVLVNQISSNIQKITLLTSELQRAISVLGTEQDSSQLLQTIQQKQQQGNHLAKETDRLMKAFTALPVGPDQRQRKIQRERLLNDFSAALNSFQKSQRDAASKEKEFVARVRASSRLSQGGQPEDSFRNVPPIPSDSQIQVQADAVTEEDLRLIQERESALRQLESDIVDINDIFKDLGMMVHEQGDMIDSIEANVENTETNIQKGVHQLARAAGHQQSSRKKICIILIVLVVVAVVVGLIIWGSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8E2</accession>
    <name>A0A3P9C8E2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Hsp90 co-chaperone Cdc37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with Hsp90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8E2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018347"/>
    <dbReference type="Ensembl" id="ENSMZET00005018939.1">
        <property type="protein sequence ID" value="ENSMZEP00005018347.1"/>
        <property type="gene ID" value="ENSMZEG00005013758.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013443"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000001">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF3">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="131"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="296"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="371" mass="43697" checksum="EF522C413626108C" modified="2019-02-13" version="1">MTMSGIDYSVWDHIYVSDDEDVTCPFVDTPSLFRMRHRSRLEKMVEFQQRGEDLETSFAECRRLLEEAQGRLAYLEERMREGGEDKEREAELKKVQTEIKKLKQDEKSFEKLLEEHQKEEKKLPWNVDTISKDGFSKSVLNFKPLSKEETGEEKVGNHKNFLRKYGKEIKLFGMLRRWDDSQQYLSDHPHLVCEETANYLAVICIEYEIDEKHALMEQVAHQAIVMQFILDLARTLKVDPRGCFRQFFSKIKTLDKSYQDAFEHELEMLKERVRSSAQTHMENAVKELEEEEIQKRLGPGCLDPVEVYESLPKEVKRSFHEKNIQMLQEAMSKLDPEEGKYHLKRCIDSGLWVPDSRGDEDGEEDGDQEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C947</accession>
    <name>A0A3P9C947_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione synthetase</fullName>
            <ecNumber evidence="4">6.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C947"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018426"/>
    <dbReference type="Ensembl" id="ENSMZET00005019021.1">
        <property type="protein sequence ID" value="ENSMZEP00005018426.1"/>
        <property type="gene ID" value="ENSMZEG00005013840.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013764"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="15">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="193" mass="21280" checksum="41196876EF2D7965" modified="2019-02-13" version="1">MPKMQSWDARRLMERSRAVKCPDIRAYLAGSKKVQQVLARPGVLERFFPDQPQAVQQIRAAFADLYTIHGEKKDTIFSFINGLAAAERFVSKPHKTVCGVCAGLYVMLGAWGLVDFDSKLILASVSHWSLGGGVKGIGWWLFLMLVFSLFSYRQGKDMVINECVGHLLRTKSSGQSDGGVAAGVTVLDNPLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBM3</accession>
    <name>A0A3P9CBM3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 117 member A</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBM3"/>
    <dbReference type="Ensembl" id="ENSMZET00005020140.1">
        <property type="protein sequence ID" value="ENSMZEP00005019512.1"/>
        <property type="gene ID" value="ENSMZEG00005014647.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183046"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026642">
        <property type="entry name" value="Glcci1/FAM117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972">
        <property type="entry name" value="AGAP011572-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14972:SF7">
        <property type="entry name" value="PROTEIN FAM117A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15388">
        <property type="entry name" value="FAM117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="425" mass="45943" checksum="A7F3007EEE618059" modified="2019-02-13" version="1">MTRLEFSNGFSSSSHHQHQRRKSRCWLTLASHHHHQSAPTSLPGRTATANNSHLELSGPRFDTVKMSGRSGAGHTRGAALGPQPLKATVPYQLASKPRPNRIDGKPARKARSHQLSPGMRRTMSLDAIIGPYLQGHWPKEPEGPSCVPRQDKSTQTPDSWSDRSHSRRGSSSHKRSASWGSAEHLREITKLKQQLQQCSKPAVSGAHDKDRQRGYPQGGRSLGAAQTQPIPIPPAPLSTLVPPLRCSVEGLNQELEGMFISQSLHPLQRLLEVPDGHRAPVPLQSCSSGSQSDPPTTPPPSSSSTSSSPSSSPNDICTSQPNSDAPPDLHQGSTDSGLLSPFPSQNEADLSPLLNASSPGPNKSCCFQRKPPEGCERVRVWEEISSPQKPTMALISSCPDPNKKLWLSSKQLLEPGNKLLSDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CC04</accession>
    <name>A0A3P9CC04_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger MYND domain-containing protein 10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZMYND10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004548698.1">
        <property type="nucleotide sequence ID" value="XM_004548641.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CC04"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019652"/>
    <dbReference type="Ensembl" id="ENSMZET00005020282.1">
        <property type="protein sequence ID" value="ENSMZEP00005019652.1"/>
        <property type="gene ID" value="ENSMZEG00005014747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479600"/>
    <dbReference type="KEGG" id="mze:101479600"/>
    <dbReference type="CTD" id="51364"/>
    <dbReference type="GeneTree" id="ENSGT00940000153820"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000009">
        <property type="entry name" value="Zinc finger MYND domain-containing protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052298">
        <property type="entry name" value="ZMYND10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13244:SF7">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="15">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="439" mass="51046" checksum="708742E10855C6DB" modified="2019-02-13" version="1">MDTSVILPVEAEGFIQSLETFSLKEVGSERWFKQHDYIEKLNMQAILNASAMHDEFVKDLLVSFGKIHILVHEMILIEVWKKKVFPILCQLEDFNPEKTFHLYMVIHHEATIINLLETIMFHKDSCDAADDSLLDLVDYCHRKLTLLASEAIKDVAVTYDQHKQTSSLEELQVQSAALEFEISLKAVSVLRYITDHADSISIISRMLCTHNLPCVLVQLIDHCPWSRCREGNVQKHIDGKWQTIPVEDHLKMNKLDGQVWLSLYNLLLKEEFQRKYNFNSFNKSQLLKLRGFLTDVLIDQLPNLVDLQRFLAHLAVSDPAPPKKELILEQIPEMWNRIISENSRKWKAIAKYQVKETFSPSESDLRQQAQRLAQTYNLDVMESLLPEKPKCGSCGREATKRCSRCRGEWYCHRECQVKHWPKHKKACQLMTETTEKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCG6</accession>
    <name>A0A3P9CCG6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal protein of 72 kDa</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CEP72 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004541498.1">
        <property type="nucleotide sequence ID" value="XM_004541441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CCG6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019571"/>
    <dbReference type="Ensembl" id="ENSMZET00005020200.1">
        <property type="protein sequence ID" value="ENSMZEP00005019571.1"/>
        <property type="gene ID" value="ENSMZEG00005014688.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474536"/>
    <dbReference type="KEGG" id="mze:101474536"/>
    <dbReference type="CTD" id="55722"/>
    <dbReference type="GeneTree" id="ENSGT00530000063884"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000489">
        <property type="entry name" value="Centrosomal protein of 72 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055320">
        <property type="entry name" value="CEP72-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311:SF5">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 72 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23311">
        <property type="entry name" value="HEAT SHOCK REGULATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="229"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="451"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="571" mass="65164" checksum="7E8421E61F37B104" modified="2019-02-13" version="1">MAAKCLTTLTEQWIRERLRLKHPCLGDVRTLSLPGTYEEKIRHLGNGLSNFIRLKSLDLSCNALVSVEGVQHLKMLQRLILYYNCIPSLEEVKVLFELPSLKELDLRLNPLAKNNPQYRLYLVHAMPTLRKLDSCSVRDAERKSALMQFSSELLPQQMSFSLNLIDDRRSSDRRPALTDRLTKSLSVLTDTRDIELNFVATNDGEQSEAVSVSFHKEADGFKEKVSEDFRKQMSSTPKQETAKSILRYPLTKTDNSESKGSQMKDLSHQKSCTSIKVPERPKVSFGPYIEQRRPAHGNPKQKDSPKQTRHPAKGHFTPNPDESLRHSSSFINIRPPSPRRPGLNLSDPFNPILHPPRLTYSSFNKTDGSSSQPGQAEKKKKGSYRKPLEMLLNLVDKHWTGERSLHQNNNFLSQAVQILSMMESDISSRETEVRTLLREADALRFQAAAREEEHKTEVHNLSAQLEEARRAVGKLNEQLRVVLEENVALQKQLIKLERQYLKSMMKSSHVSQIREAQAEVEELKKEIEGLRKKVQEAEKVKELSDMLQESHRSLVATNECLLAELKGSGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CE00</accession>
    <name>A0A3P9CE00_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AT-hook transcription factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004538657.2">
        <property type="nucleotide sequence ID" value="XM_004538600.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012772724.1">
        <property type="nucleotide sequence ID" value="XM_012917270.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012772726.1">
        <property type="nucleotide sequence ID" value="XM_012917272.1"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005020121"/>
    <dbReference type="Ensembl" id="ENSMZET00005020768.1">
        <property type="protein sequence ID" value="ENSMZEP00005020121.1"/>
        <property type="gene ID" value="ENSMZEG00005015096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474788"/>
    <dbReference type="KEGG" id="mze:101474788"/>
    <dbReference type="CTD" id="80709"/>
    <dbReference type="GeneTree" id="ENSGT00940000154254"/>
    <dbReference type="OrthoDB" id="10035553at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001837">
        <property type="term" value="P:epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060234">
        <property type="term" value="P:neuroblast delamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021849">
        <property type="term" value="P:neuroblast division in subventricular zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052655">
        <property type="entry name" value="AKNA_Centrosome-Trans_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21510">
        <property type="entry name" value="AKNA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21510:SF15">
        <property type="entry name" value="MICROTUBULE ORGANIZATION PROTEIN AKNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
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        <location>
            <begin position="706"/>
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        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
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        <location>
            <begin position="263"/>
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            <begin position="310"/>
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            <begin position="402"/>
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        <location>
            <begin position="537"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="675"/>
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    </feature>
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            <begin position="1001"/>
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        <location>
            <begin position="1200"/>
            <end position="1209"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1392" mass="154548" checksum="2335DA41F1D7DAF9" modified="2019-02-13" version="1">METRQNTTAGVLFWTPAPVHSSPNSTAISEDEWDEEDEEQAEEEDDFFSQMDENGIIGLSEALENVELEECNSDGCPGSLTPEEADYSVAERDTPSEEMIYKLSKHLSHHKPTEEDTGKLSSYELKTWSEDMEVRRRMEEQVAEHLSEWNKHHDTTNDDKDGEERGRSDWSKKKFEHTRTSGELGRKLAGLAEGYRDKEEKKEISSGQSSSVQLHAVDSVSCPASRSALPHRLHFTAEELNTAPGIEAETFPEISFTESFQESNSSHVSLNSSPHCPEIKLRASPQPAALFSEQVISNHYRRLSNGPGKESGKRDKEHSHPTPTPRKIRKHSPEAAYSRTHSPGTVRPNKQQNTRRDRDVVTPRTRSNAVAEDESRKGPLSYHTPDFSKVEPRVHFPKGGYKPPKSRSSLTRKSLSPEPAIVFKSPADIVKEVLLNTAGESPTSPDSDGQATSAINAIVPQEFRCHQQATTLVNQLQEDYDRLLTKYAEAENTIDRLRLEAKVNLYSDPPNPGHCVQSGLNCGASKLLKFDFPRAQKPTTDQGSSATGPTEPGSKLGQQLANILFSQAETFLQQLQTFEDLRKSKKLQPFEQTEGMAQLAEGLESLERGYLLARDEHKLLQQRGIEISQFDPERELEGLIFQCGLRTDELKEQVEQMQPDQPTWITPPSPPPQPTTPSALSVDVVTFTHPQVLPVPLLSGAAEAEVSSACKENDEEKSEGEDEETLYLNPLKGKIKSVAEDFTMAVNHYRSIKELPKLLERSLNEAVLSSPALRTNMQSEHKDRQETGNNEVWKTLSQRNAQSDHQGYSSDVNKQQNSRSSPRPASSRLMMFPVFRQSNIKRVEVGKSHSSSLSSLGDVKVSEVRSSEVQAGGRRVFSQDGIISPETDSGFVGSESSRLTPATSSPLHQRALESGVPVPQEGSTSLQTGRVFAPSHFSSPLHSHTAKDLIMSSRLSLSLDQPQRCRRAVRRRTSSCSPKRCVNLRQQRVASGSSEFGLESDGTRIDSEGEKTDQYSKSINFLDSSHSSSSTTTQHHLCDSPRARSSSQNCIDAVQILQAEVTKLKERLEDSLRNKKPISSIRSAPSTQDNSSNQSSSSSCFRSREQRSDVSAGKRETQMVDEVAEESTQRRIARRKSAINQQEPQHDYLTRSALQPCAPQPQVSRCTQTSAALDSCSSHTTTVYSRRTQHRKHPVVSVSEKGDEPDSRRSQAPVCSQCLSFHRASPERPAGGGREMLHSSTCCHQCPLCGRLESYKVIKPDSHRLSDTSTHIKYQPAESPDGAVGSRFFASAAPPALLQCMPVCPPPLLLYSSPLYVSPNRTPMSAEVTGPGEVRRRTKRRSLSVDRERSLDSSLNKAIRAARHMKHTSRHMAGSLASGLQYQELLTQSCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CE06</accession>
    <name>A0A3P9CE06_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="2 3">
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        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSMZEP00005020372.1"/>
        <property type="gene ID" value="ENSMZEG00005015273.1"/>
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        <property type="component" value="LG15"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="167" mass="17389" checksum="85D0C9E1B5E13857" modified="2019-02-13" version="1">AAGGAGPALERLSGGASPKMASSEMSQHPQHTAPEHGGGPNKGGCQRHLGRNRLLAGPRSPSSLTPRQLAGPRSPSSLTPRQLAGPRSPSSLTPRQLAVFSFVCSCTSRPACSSCTSCTLVLHVLHVPLVLHVLHVLLVRSGLLVLHVRSDLHILSGLLVLHVLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEX9</accession>
    <name>A0A3P9CEX9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEX9"/>
    <dbReference type="Ensembl" id="ENSMZET00005021389.1">
        <property type="protein sequence ID" value="ENSMZEP00005020707.1"/>
        <property type="gene ID" value="ENSMZEG00005015544.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12893">
        <property type="entry name" value="SPRY_PRY_TRIM35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
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    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
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    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="270"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="176"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="463" mass="53552" checksum="DF2D0080815AE98E" modified="2019-02-13" version="1">MASRSEEDLCCPVCQEVFTDPVILSCSHSFCKDCLKRWWKERPTHECPICKRRSSRPEPPLNRALKNLCELFLQDRDQRAPEALCSLHSEKFKLFCLDHQQPVCVVCCASDKHTNHRFRPIDEAAQQHKEELQENLEALKKKLKICEDVQVKFDQTAKHIKVQTRHTERQIKEQFKKLHQFLAEEEEARLAALREEEEQKSGMMKEKMEALSREIAALSDTVRATEEELRAEDVSLLHNYKAAVERVQRCSLLDDPQLPSGALIDQAKHLGNLTFNIWNNMNDMVSYTPLILDPNTAHPQLILSKDLTSVRRREERQQFPDNPERFDYYISILGSVGFTSGTHSWNMEIGDSTGWVLGLLAESDERKGDKLSGLWGIRHILDKYYAVSPLAPKTPLSVQKKFQKISVNLDWNNRKLLFYDPDTNTHIHTFNNTFTHKIIPYIYTNGKVKVLPLKVSVSVEQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFU9</accession>
    <name>A0A3P9CFU9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CFU9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021155"/>
    <dbReference type="Ensembl" id="ENSMZET00005021850.1">
        <property type="protein sequence ID" value="ENSMZEP00005021155.1"/>
        <property type="gene ID" value="ENSMZEG00005015875.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161758"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043195">
        <property type="entry name" value="TTC12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46540">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46540:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="227" mass="25874" checksum="20A9B5CDB60389AE" modified="2019-02-13" version="1">MKIMEMDAEERKVRKAANVKKAIAFKDKGNEAYAQEDYETAVKYYSDGLAEIKDMQPLYTNRAQVNIFNLCFTMKTQTSLFSQGETECIKAYLHMGKAYLGLKKYNEVSKNTSHYKYLTQVDLGKEKETQEIKAREEFDKGKRKATTVVELLEKLSKPGQIALYYCGGLEILSQALTDCECSNNCVSPLITVFSFFLVDCVSGAPICWFYDKQTNKQTNNNKKRISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGD0</accession>
    <name>A0A3P9CGD0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGD0"/>
    <dbReference type="Ensembl" id="ENSMZET00005021603.1">
        <property type="protein sequence ID" value="ENSMZEP00005020916.1"/>
        <property type="gene ID" value="ENSMZEG00005015700.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234589"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000283">
        <property type="entry name" value="Immunoglobulin kappa constant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018113971" description="Ig-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="119" mass="12730" checksum="A87040BC34BC54DA" modified="2019-02-13" version="1">MSWQHFGRTFLKSIFIRPTLTVLPPSKEEDKQSSATVVCLATGGFPSNWNLGWKVGSTSTSSGVSTSLEVLGTDGRYSWSSTLSLSADQWKKAGSVSCEASLSGQSPVIQSLDPDHCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHN9</accession>
    <name>A0A3P9CHN9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinase</fullName>
            <ecNumber evidence="6">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004548845.1">
        <property type="nucleotide sequence ID" value="XM_004548788.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004548846.1">
        <property type="nucleotide sequence ID" value="XM_004548789.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHN9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021549"/>
    <dbReference type="Ensembl" id="ENSMZET00005022259.1">
        <property type="protein sequence ID" value="ENSMZEP00005021549.1"/>
        <property type="gene ID" value="ENSMZEG00005016178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467562"/>
    <dbReference type="KEGG" id="mze:101467562"/>
    <dbReference type="CTD" id="9807"/>
    <dbReference type="GeneTree" id="ENSGT00940000157802"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.160:FF:000002">
        <property type="entry name" value="Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF73">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="516" mass="57770" checksum="47561779EB34D815" modified="2019-02-13" version="1">MCLPHTNNMDSKLQGAGTGGGASLRPRAGGVPLEPFIHQVGGHTSMMRYDDHTVCKPLISREQRFYESLPPEMKEFTPEYKGVVLVCFEGDSDGYINLVAYPYVESNMEGGAGEHEERDPPEREQPRRKHSRRSLHRSSSTSEHKEERPDRREAHDTETSDNLAELKSPRLDPKVLSDVPFQMLDWNSGLTSEKISHNPWSLRCHKQQLSRMRSESKDRKLFKFLLLENVVHHFSYPCILDLKMGTRQHGDDASEEKAARQIRKCEQSTSATLGVRVCGMQVYQLNTGHYLCRNKYYGRGLSIEGFRQALYQYLHNGKGLRRDLFEPILDKLRTLKAVLERQASYRFYSSSLLIIYEGKEPESPSVWQPKTSVSPAESHCGPAPDAPCETDMSQKPDTGSLPSQGSGLMAPASPSPSPHPPTQAPPPKSDCHSFLPRPPSPHPESTSSAPSLGSFPSPAPLPQQPPLVDVRMIDFAHSTFKGFRGDTAVHDGPDRGYMFGLESLVQILESLRDDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHT6</accession>
    <name>A0A3P9CHT6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin IH</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHT6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021848"/>
    <dbReference type="Ensembl" id="ENSMZET00005022563.1">
        <property type="protein sequence ID" value="ENSMZEP00005021848.1"/>
        <property type="gene ID" value="ENSMZEG00005016361.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156430"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000085">
        <property type="entry name" value="Myosin IHa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF852">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-IH ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="11"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="11">
        <location>
            <begin position="743"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="950" mass="109436" checksum="54953EEA371B077E" modified="2019-02-13" version="1">MEGALTARDRVGIQDFVLLDETTEAAFLSNLKKRFSKDLIYTYIGTLLVSVNPYKELDIYNKKQMDIYMGVNFFELPPHIYALADNAYHTMLTEFNNHFILISGESGAGKTEASKKILQYYAVSCPSTTLLNTVRDKMLMSNPVLEAFGNAKTLKNDNSSRFGKYMDIQFDSQGDAVGGHILNYLLEKSRVVHQNHGERNFHIFYQLVEGGSDDLLHQLGLERGCQHYNYLTQGQCPIVPSINDKNDWKTVKNALQIISFDETATNHLFEVIASVLHLGNVRFDSDSKGHALLNNNTELHWVSNLLGVDAHRLQEGLTFRKIEAKKDQVLSPFTTDHAIYARDALAKAIYGQTFTWLVNRINESMENEDPSRKTVIGLLDIYGFEVFYVNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIEWEPVQFFNNKIICDLIEEKHTGIISLLDEECLRPGDATDLTFLERLEEKMGNHPHFVTHKLADKMTRKTLERGDFRLLHYAGEVTYCVLMCQSKNDIVKECFSSMDPDSRRRPETVVTQFKSSLQKLTEILVAKEAWYIRCLKSNESKQSGQFDEALIRHQVKYLGLMEHLRVRRAGFAYRRKYDVFLKRYKPLCPATWPHWRGVAADGVEVLVQHLGYLPDEYKMGRTKIFIRHPRTLFATEDAYEKCKHELATRIQAKYKGYRAKGEYRKQKEAATKIESCWRGTQARKEKEKRAWAVKVIKKFIKGYMTRGQAKNTDNSEYLAFVRQNYLNRLRDNLPKTVLDKTPWLTPPAVTDFLHYRLMVRKYVRGITPQKKAQFEMKLITSSVFKGKKDSYPQSVAHPFADTRIKISVSNLTDSTIVFHITREEPKQKGDLVVQCDHLFELLTKLCVIVNKQNAIKVVQGSINFEIQAGKGGAVDFSTGPEPMVYKAKNGHLMVVSWQFYAPAHKKTSNRSHPQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CIV4</accession>
    <name>A0A3P9CIV4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase family member 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014269520.2">
        <property type="nucleotide sequence ID" value="XM_014414034.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023011199.2">
        <property type="nucleotide sequence ID" value="XM_023155431.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CIV4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022228"/>
    <dbReference type="Ensembl" id="ENSMZET00005022970.1">
        <property type="protein sequence ID" value="ENSMZEP00005022228.1"/>
        <property type="gene ID" value="ENSMZEG00005016667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478370"/>
    <dbReference type="KEGG" id="mze:101478370"/>
    <dbReference type="GeneTree" id="ENSGT00640000091701"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053998">
        <property type="entry name" value="ACDH-11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22217">
        <property type="entry name" value="ACDH-11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="8">
        <location>
            <begin position="75"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="231"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="346"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase 11-like C-terminal" evidence="9">
        <location>
            <begin position="510"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="636" mass="70038" checksum="8A5678B371E5CF88" modified="2019-02-13" version="1">MSVSSALLSRRVAGGSCRLWCVIPSPRPLIHVRSASVAEPGRRRSNEEQLWEAAGYLPFTRARIGPFFQENPVLKNPFVEDALLRGYLKRHIPQEVILSDLCAFGEHVAKEVDGWGRECEVNPPRLVHFDPWGRRVDHIVTSHAWKRMKDLSAQEGLVAIGYERSFGEWSRVYQMSKLYLFSPSSGLYTCPLAMTDGAAKVIQSLGVSWPVEDAYSRLTTRHPERFWTSGQWMTERQGGSDVASGTETVAVPQTDGSYKLHGFKWFTSATDADMTLTLARVQDKTGATIPGSKGLSLFYAEVSRDEDGRLRGIEVQRLKDKLGTRQMPTAELLLDGLPARRLSEEGRGVSSIANMLTITRIHNSVSAAAAMRRVLQLARDYATRRTTFGKLLKDHPLHMQTLARMEVESRGAFLLVMDVCRLLGREESGVATEHDAHLLRLLTPVVKLYTGKQAVAVVSEGLESFGGQGYIEDTGLPGILRDAQVLSIWEGTTNVLSLDVLRCVARSSGMVLHAYFSHTKSLLAGASSVSSLAPAVTAVGGALCELEEFVQVAATRAPSYLELAARDLAYSLARIYTGALLIDHACWKGASPSDTYAALRWCEQDLCPVARNQRRGHYDSNTSLDAALVFDQSIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJC9</accession>
    <name>A0A3P9CJC9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 79</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004574360.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJC9"/>
    <dbReference type="Ensembl" id="ENSMZET00005023170.1">
        <property type="protein sequence ID" value="ENSMZEP00005022423.1"/>
        <property type="gene ID" value="ENSMZEG00005016799.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005023174.1">
        <property type="protein sequence ID" value="ENSMZEP00005022427.1"/>
        <property type="gene ID" value="ENSMZEG00005016799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464882"/>
    <dbReference type="KEGG" id="mze:101464882"/>
    <dbReference type="GeneTree" id="ENSGT00390000002390"/>
    <dbReference type="OrthoDB" id="8887147at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31004">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31004:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="136"/>
            <end position="159"/>
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        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="426" mass="46090" checksum="FFCE8AE79EB984DE" modified="2019-02-13" version="1">MSTSGLQATNRQNAKELDSMKESISDIINQLQDIDPARLSFSPFLDLDTQISLAPVSDSPESSVEELHSSSHSVSGSQRSLEPPPATDQPRSSAPCHQQSGVSLPQEPRAHRGEEGELDQTLSSPIITARNLDAATENCVGPPTPASQGDIPNGTDAPRWSPESTNLDCTVDEGRPLIGPPPESVELAVWSSEGRGETCVAAREASDRGQCRCCQCTCCQSSRVPAFFSVLASLLCASGILYALYFYVPIKPPDFPDVTSRIVFTLCCCVVAAVPILLAMLMGAACQFCNGSFDLQESFPRRGAVQQLFVTTSLEQLLLYVLNLVVMAALLPQDQLKLVPILVIMFIFGRLVYWVALNTCVSWRGFGSGLSVFPLLAMVALNLFLVYMLHLREPLFGSQDVLYNQVTPSSWSSQSPSATPDILDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKF4</accession>
    <name>A0A3P9CKF4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Lysine-specific demethylase 4B</fullName>
            <ecNumber evidence="4">1.14.11.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">JmjC domain-containing histone demethylation protein 3B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Jumonji domain-containing protein 2B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">[histone H3]-trimethyl-L-lysine(9) demethylase 4B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004562084.2">
        <property type="nucleotide sequence ID" value="XM_004562027.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKF4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022790"/>
    <dbReference type="Ensembl" id="ENSMZET00005023542.1">
        <property type="protein sequence ID" value="ENSMZEP00005022790.1"/>
        <property type="gene ID" value="ENSMZEG00005017065.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101472369"/>
    <dbReference type="CTD" id="23030"/>
    <dbReference type="GeneTree" id="ENSGT00940000159248"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000029">
        <property type="entry name" value="lysine-specific demethylase 4C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000003">
        <property type="entry name" value="Lysine-specific demethylase 4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.70:FF:000001">
        <property type="entry name" value="Putative lysine-specific demethylase 4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040477">
        <property type="entry name" value="KDM4-like_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18104">
        <property type="entry name" value="Tudor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="24">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="25">
        <location>
            <begin position="234"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="26">
        <location>
            <begin position="811"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="534"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="633"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00080011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1241" mass="137990" checksum="0349B55359E0E1FE" modified="2019-02-13" version="1">MATDMPMEDVLGPHPAPASSTPPDPVSPPTLSSNEAQNQIPTLEPAIAENLNKVVISEHNAAPHLNPVQPADPNVAPELVPGAEVSPVPLPAPLPPAAAKNPSCKIMTFRPTMEEFKDFAKYIAYMESQGAHRAGLAKVIPPAGWKPRKSYDTIEDMVIPAPISQVVTGQSGLFTQYNIQKKSMTVGEYRKLANSKKYCTPRHKDFDDLERKYWKNLTFVSPLYGADVSGSIYDENIEEWNIGHLNTLLDMVEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGQSKSWYSVPPEHGKRLERLAQGFFPGSSQGCDAFLRHKMTLISPSILKKYGIPFNRITQNEGEFMITFPYGYHAGFNHGFNCAESTNFATLRWVDYGKMATLCSCRKDMVKISMDVFVRRLQPVRYDLWKQGKDTTVLDHLKPTELTSPELESWREHRVAQRANLLRRAMQKMKQFRRLKLEEVKVLAEEGIELNAVEYQRQVEEREAQRRKEKEARLAREAMITLEALEREEQQAAEAAAKVVETPAAEGQEQETKPQNLTDDIEKKKQRKPKKISSGQNAITGFEEAFKQFATSDDKNSKRETARHLDTLSPRHSDILADNKMDVSATQATYPKRKIPTEIKKSRRHPLSKPPTRSPLSIVKQDPASDKDMASPMPMDSDMKKQEHLWQNHSPNFLAEKAFNAAVAALKPHCAVCSLFCPYTKKDVSTDNETLGASFPRHGSLTRPLVPEMCFSVGAGNTEPPPTNYHIGEDGTSLLICCSSCQMQVHASCYGVKPDSVGDSWMCSRCAAGAWTVECCLCNLRGGALKTTTDNRWVHVICAIAVAEARFIDAIERGPVDVSAVPETRKNLKCVFCHGKVASQNRGACIQCTYENCATSFHVTCAQIAGVVMTPADWPYVVSVTCHKHKKVTPKPRPTPKGPQEPTLGQRVIGRNANSWYYHCTVIGMARQTFYEVNFDDGSYCDNLYPENIMSHDCLRSGPPKVGELVVVGTHEGKILNASFVKPHIHKLYQVEFQDQSQLMVKHSEIFQLNQELPKRVRARLALPGTQEEVPSVDEARAAKRRRLTATLPPPGPAPANIPMETTNATPCPQTKAPVTKPAPENHSIGTQLTLQPLSQPPMIQQDAPAPASGIQMDAETPMDIGVALTDPLTGSPLISDPLLSSESVPFQSTLNSNPLLSAPSLPSLPAQHMSDSYTPSSGYVSYMKTLLHSHFPQEDGPEPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKM6</accession>
    <name>A0A3P9CKM6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Frizzled class receptor 8a</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKM6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022878"/>
    <dbReference type="Ensembl" id="ENSMZET00005023630.1">
        <property type="protein sequence ID" value="ENSMZEP00005022878.1"/>
        <property type="gene ID" value="ENSMZEG00005017130.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161191"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060898">
        <property type="term" value="P:eye field cell fate commitment involved in camera-type eye formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021879">
        <property type="term" value="P:forebrain neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021529">
        <property type="term" value="P:spinal cord oligodendrocyte cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021531">
        <property type="term" value="P:spinal cord radial glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15250">
        <property type="entry name" value="7tmF_FZD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07461">
        <property type="entry name" value="CRD_FZ8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000004">
        <property type="entry name" value="Frizzled class receptor 8a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000053">
        <property type="entry name" value="Frizzled class receptor 8a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041776">
        <property type="entry name" value="FZ8_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF90">
        <property type="entry name" value="FRIZZLED-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018254220" evidence="16">
        <location>
            <begin position="30"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="17">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="18">
        <location>
            <begin position="221"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="563" mass="63670" checksum="4B4EB1BA3602C1C3" modified="2019-02-13" version="1">MGSPRKMDLFGIYLLLSLVLFPRSSCTTAKEITCQEIAVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERARAGCAPLMRQYGFPWPDRMRCDLLPVQGNPDTLCMDYNRTDSTTAPGTPGKYKPPAAPCEPGCTCLEPMVPVNTERHPLYNRVKTGQITNCAMPCHNPYFTHDERAFTAFWIGLWSVLCFVSTFATVATFLIDMERFKYPERPIIFLSACYMFVSVGYIVRLIAGHEKVACNREFDVEHIHYETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHLAAWLIPSMKSIAVLALSSVDGDSVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFYEQHNRQSWEVTHNCFNCLLERDRRTPDYAVFMLKYFMCLLVGITSGVWIWSGKTLDSWRTFCTRCCWGSKGTSGSMYSDVSTGLTWRSGTASSVSCPKQMPLSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQ09</accession>
    <name>A0A3P9CQ09_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564970.1">
        <property type="nucleotide sequence ID" value="XM_004564913.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQ09"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024435"/>
    <dbReference type="Ensembl" id="ENSMZET00005025236.1">
        <property type="protein sequence ID" value="ENSMZEP00005024435.1"/>
        <property type="gene ID" value="ENSMZEG00005018266.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464933"/>
    <dbReference type="KEGG" id="mze:101464933"/>
    <dbReference type="CTD" id="23554"/>
    <dbReference type="GeneTree" id="ENSGT00510000047764"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03157">
        <property type="entry name" value="TM4SF12_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF462">
        <property type="entry name" value="TETRASPANIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="254"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="311" mass="34868" checksum="3422D21C225E56B8" modified="2019-02-13" version="1">MAREDAVRCLRCLLYALNLLFWLMSACVLGVAVWIRDSLNTVLTLTAHTRLEEAAVLTYSPAVHPVIVAVCCFLIIVAMVGYCGTLRCDLLLLSWYFGSLLVIFCVELASAVWTYEEPSVQRSDMISLKSRMPNYGLQRYQWLTHTWNSFQTEFKCCGVIYFTDWLEMTEMEWPPDSCCSNQYPGCARHAHYHDLSDLHQEGCGPKIYTFIRGTKQLQVLRFLGVSIGVAQIIAMALTLTLLWALYYGRKSPEPDMPTLPPPDDPDPDTAAHAASADALKSGCSRSNKGCTNMAATTPKQQFEMERLHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQR3</accession>
    <name>A0A3P9CQR3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 526</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550947.2">
        <property type="nucleotide sequence ID" value="XM_004550890.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQR3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024688"/>
    <dbReference type="Ensembl" id="ENSMZET00005025496.1">
        <property type="protein sequence ID" value="ENSMZEP00005024688.1"/>
        <property type="gene ID" value="ENSMZEG00005018444.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162624"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001174">
        <property type="entry name" value="zinc finger protein 527 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003340">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002212">
        <property type="entry name" value="Zinc finger protein 672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF69">
        <property type="entry name" value="ZINC FINGER PROTEIN 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
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            <begin position="834"/>
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    </feature>
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            <begin position="145"/>
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        </location>
    </feature>
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            <begin position="194"/>
            <end position="230"/>
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    </feature>
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    </feature>
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            <begin position="793"/>
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            <begin position="152"/>
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            <begin position="550"/>
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    </feature>
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            <begin position="814"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
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    <sequence length="1084" mass="120311" checksum="C5061BF38AB9CCE4" modified="2019-02-13" version="1">MAEQQQQEEAEGVYVEHQYMCSECHQLFNTLEDVLVHQQIHMGQEEEGEGEVTEAMTIHGVPEVGQSQQYQCLECGSLLMNPEELLQHQEMHMREVGIEVEQQELCEVMEAEEAGSEAQVAGPVQYQCLDCLALFDSPETWLEHRRTHSRSSTHSNTETTEYMLQPDGTVTPLTNVQNYVLSEQQAGEILAQVLAHQQQQQQQRKHHSASKPAAPSRSSLLPPVTPTPGSATMHLQILTAQALADSSTTPGRRRSKLPALLPSVGHSSSVKLENGIQRLELRLAPGVHPDSQQQQPTEVVVIHPYECSECSLLFQTPEDFLQHQGDHFLGQDKESGEPGVMSGIEEVRWREEMTEKVDDIRIRGAEKKTAVWAKPQQCELCNRTFTSVNRLAAHKRVHEQGTHECPECGKVFKKATSLQTHMRTHSGVARYLCVDCGNGYTTEMTLIMHRKSHTADPLHKCNFCNKTFTNMTKYLYHRRIHLNRDTSGASIPVPAVSAPRRASASALAILQRARMKKYFPNDEAKIDLLAPLTEEDTVKLGDTRQSPQSKAERREDEKKVGENSMEVSEPCEEKLDDVQQVKDGSATEPAARGDAGVAVSCSPTDEADVASATPSEKGSFSCRSCPKTFTSQLQLVQHRRKSHVPERSFVCGMCGKSFKKQIHVRNHIRTHTGERPFQCSDCGKTFSSLANLTRHNLIHSGVRPYRCDVCHRSFSQSSNLRQHSLLHSSAATLSCPDCPATFRWPTKLAAHRFTQHPGSPAPFPCFHCEAGFLTNRQRESHCLQEHPGLVQAAKESEEGKENGSQADAGKDLTSEPSTSTSESGDSSSHVRGSLDCNVCGKKLNSPANLRLHRLSHFTLGPGRPRCTPGKRPKAHQCPLCGKLFVSSSGVALHQRVHTGERPFPCQVCGKRFRQNTHLREHLRTHSGERPFRCEICGKGFIQSMHLAEHRRTHTGERPHVCPLCGKAFKTFSNLRNHKKTHVRQQRLDEEAAAQAALEVSSAVAVVDASAVEVSNGQPQVIQIQSSDLQQAPTIMCNEFGETIAIIETSEGAVLPLEQALEIYHTALENGLAMDTVAVDGLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRW5</accession>
    <name>A0A3P9CRW5_9CICH</name>
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        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="protein sequence ID" value="ENSMZEP00005024566.1"/>
        <property type="gene ID" value="ENSMZEG00005018366.1"/>
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        <property type="component" value="LG16"/>
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        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0055013">
        <property type="term" value="P:cardiac muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="FN3_dom"/>
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    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF13">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="69"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="161"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27588" checksum="17138BBBA9660188" modified="2019-02-13" version="1">MGLLHYSNFPICFSEKPGIPQQPFIISSTKDSCVVCWKPPSSDGGAKITNYYLEKREKKQNKWMSVTTKKIAETNYEVTGLIEGFEYEFRLRVSGVPPPTLKWQKDGHPLQFGPKVVVIQEDVDSHVLHIRETLLEDSGVYKVTATNSAGTASCQAKLSLPARILTKPQSVTVEEGETVRFTCDIDGEPAPTVTWIHESRTIVSSHHIQDLTTLIITGVKKEDAGSYTLKLSNELGSDTATVHISIRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUF7</accession>
    <name>A0A3P9CUF7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pleckstrin homology domain containing, family O member 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004572279.1">
        <property type="nucleotide sequence ID" value="XM_004572222.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUF7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025662"/>
    <dbReference type="Ensembl" id="ENSMZET00005026495.1">
        <property type="protein sequence ID" value="ENSMZEP00005025662.1"/>
        <property type="gene ID" value="ENSMZEG00005019154.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471170"/>
    <dbReference type="KEGG" id="mze:101471170"/>
    <dbReference type="GeneTree" id="ENSGT00530000063760"/>
    <dbReference type="OrthoDB" id="6358316at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036195">
        <property type="term" value="C:muscle cell projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901739">
        <property type="term" value="P:regulation of myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13317">
        <property type="entry name" value="PH_PLEKHO1_PLEKHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043448">
        <property type="entry name" value="PKHO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15871">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15871:SF1">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY O MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="616"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="656" mass="72454" checksum="B2091C0507FA8F62" modified="2019-02-13" version="1">MKKSNQSRRGVQDSGPLPVQQPEKVGWIRKFCGRGIFRELWRSRYMVLRGDHLYISDKEVKDERKAQEVFDLADYERSEELRKAKSRSKKNHSRFTVLRCKQPGNTAPNLVFLAVSPEEKESWVNALSIAIIKAKNRVLDEVTIEEDSTLVHPTRDRAKIPYGRRLPTKGHLMAVASTSSHGMLTLDLVAEEDVFSHDYDGDWNNSFRVDLQGGGSCGQIGVGRQRAGTDVSKLRMTSKEPKVKTSSLPRGSERSWGKHLEASKVHKSPQIEVLQAQYRTPQPGKRFSMQGRSRCASMDEVLSSRPVMIRSEFCSAVGRCPAEVEAGVEASAQPLGQIQSLIAQRMQRAQELLEEMRLQELQKTKAEREREGSSPYLKGINSPRLHHLRGSESPHSSRSSGSPRSRSSDSPRLRGRESPRSKAKKNRSKGTDSPHSRGSHAAAAKVSDSPRLSGSPRSKSTDAARSPKLKGPSAASPNKQGSSPIQKPSDSPLSVGRSDFSQVKGYGSPQGSETDSPHLGSNEESPLQSQNSPTLSRSFESSQPTTLDSHHPSPPPPATQLSEDNSEVEQRRAEAERLLEEAVSSWKEAQEVLQEVKELQSQTLRRQRRRTYEKMASAAAAAGIPAPSGAAEEMDTLISPTSPEDKEDSETPERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVS5</accession>
    <name>A0A3P9CVS5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hedgehog acyltransferase like, b</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546798.1">
        <property type="nucleotide sequence ID" value="XM_004546741.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVS5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026490"/>
    <dbReference type="Ensembl" id="ENSMZET00005027347.1">
        <property type="protein sequence ID" value="ENSMZEP00005026490.1"/>
        <property type="gene ID" value="ENSMZEG00005019764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472622"/>
    <dbReference type="KEGG" id="mze:101472622"/>
    <dbReference type="CTD" id="792224"/>
    <dbReference type="GeneTree" id="ENSGT00530000063629"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF21">
        <property type="entry name" value="HEDGEHOG ACYLTRANSFERASE-LIKE, B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="533" mass="61582" checksum="455618F68C184C63" modified="2019-02-13" version="1">MGLKAALPKYEIYFYNTVLCLAMFWATSWIFEVSSSSANRKTFKTSVKPGWYYFGRKMETADFEWLMWFSTFRDHIIFALSGHVLFAKICSMLAPQYRSLVYMVYGLLAVWTSMGWTYVTLILSHCILLYSISLVKIRWLCFVTGLCTLATFKCEPFISWQAGFVEGDFELRPVFFYGGCGFTIMRCMSFALENCERKDGNYNILELLKYNFYLPFFYFGPIMTFDKFYVQVNRCDLTRKEREMWNINLHGVIHLIVIIVVDILFHFMYILTIPTDLKLMKHLSDWALVGLAYFNLVYDWVKAAVMFGVINTVSRLDHLDPPKPPKCITMLYVFAETHFDRGINDWLCKYVYNYLGGKHENMVEELVATLCTFGITILWLGPCQVVLVWAFLNCFGLNFELWTGKFFSVEPFSSFEMAMSEAMSRRIRAIFNTFNFWSIVLYNILALNSLDFAKLVAKRLLLKGFPITTIIVMFVTYCLIQVIKEQERRQALIDDPDPLPPAPPPNAATSPTTSATAPTAAQPVADPSKEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CX55</accession>
    <name>A0A3P9CX55_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CX55"/>
    <dbReference type="Ensembl" id="ENSMZET00005027825.1">
        <property type="protein sequence ID" value="ENSMZEP00005026960.1"/>
        <property type="gene ID" value="ENSMZEG00005020110.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162108"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000002">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000009">
        <property type="entry name" value="WC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF22">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="120"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="224"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="329"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="432"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="535"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="657"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="765"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="858"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="146"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="159"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="250"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="263"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="355"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="368"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="561"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="574"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="884"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="897"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="965" mass="101887" checksum="5C9CF2410398B31C" modified="2019-02-13" version="1">VSIILTGSGSTRCPIRLTGSGSSRCSGRVEVYHNNSWGTVCDDGWDLNDAEVVCRQLNCGSALEVPQSAHFGAGTGQIWLDNVTCSGNESSLTECQHSGFGSNRCEHGQDAAVICSAVSIILTGSGSTRCSGRVEVYHNNSWGTVCDDGWDLNDAEVVCRQLNCGSALEVPQSAHFGAGTGQIWLGNVTCSGNESSLTECQHSGFGSNRCEHGQDAAVICSDLIRLTGSGSSRCSGRVEVYHSNSWGTVCDDGWDLNDAGVVCRQLNCGSALEVPQSAHFGAGTGQIWLDNVTCSGNESSLTDCQHSGFGSNGCEHGQDAAVICSAVSIILTGSGSTRCSGRVEVYHNNSWGTVCDDGWDLNDAQVVCRQLNCGSALEVPHSAHFGAGTGQIWLDNVTCSGNESSLTECQHSGFGSNSCVRGQDAAVICSGEKTVTGSGSSRCSGRVEVYHDNVWGTVSDHNWVLNDAEVVCREINCGSALEATPSSKFGAGTGQVWLSGVSCSGSESSCYASVFSLRYVLKYSLCYVFYIKGVIRLTGSGSTRCSGRVEVYHSNSWGTVCDDGWDLNDAEVVCRQINCGSALEVPQSAHFGAGTGQIWLGDVSCSGNESSLTECQHSAFGPNRCEHGQDAAVICSGVKTVRLYLNVFHVLSLLDLIRLAGSGSSRCSGRVEIFHNNVWGTVSDYNWDLNDAEVVCRQLNCGSALQAPRTAYFGAGTGQIWLSGVSCSGNESSLTECQHSGWGNYYYYYYNRHYYDAGVICSGPIRLTGSGSSQCSGRVEVYHSNSWGTVCDDGWDLNDAEVVCRQLNCGSALEVPQSAHFGAGTGQIWLDNVTCSGNESSLTECQHSGFGSNTSVSIILTGSGSTRCSGRVEVYHSNSWGTVCDDGWDLNDAEVVCRQLNCGSALEVPHSAHFGAGTGQIWLDHVTCSGSESSLAECQHSGFGSNRCEHGQDAAVICSGVKTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYS1</accession>
    <name>A0A3P9CYS1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CYS1"/>
    <dbReference type="Ensembl" id="ENSMZET00005028373.1">
        <property type="protein sequence ID" value="ENSMZEP00005027500.1"/>
        <property type="gene ID" value="ENSMZEG00005020506.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234576"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000966">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000875">
        <property type="entry name" value="zinc finger protein 236 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001134">
        <property type="entry name" value="Zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="522" mass="59549" checksum="6138A313D4DFAA1A" modified="2019-02-13" version="1">MPPAPFTVKASLKQHQVIHTGERPFSCDLCGKSFSMKDSLKKHQLIHSGVKAYSCYQCGRAFTHSSNLQRHLVTHSGIKPYSCDQCGRAFTRSSHLQSHLVTHSGIKPYSCDQCGRAFTQSSSLQRHLVTHSGIKAYSCDQCGRAFTQSSSLQSHLVTHSGIKAYSCDECGMEFTLKASLKQHQVIHTGERPFSCDLCGKSFSFKVSLKKHQLIHSGVKAYSCDQCGRAFTQSSHLQSHLVTHSGIKAYSCDQCGRAFPHSSSLQRHLVTHSGIKPYSCDICGKTFSQRGHRNEHLRIHTRHDVYCCEQCGKYFTTDADLQRHMFTHTEERPYQCDLCEKTFKSPHHLRRHQQIHTRKRLYKCSYCETLKVHQRRHTGDQRKYCKECGRSFTTSSELKRHELIHSGVKKHLCDQCGSSFTTARDLKSHKRVHTGEKPHKCRHCERSFSQSGSRNIHERAHMEGNYSCDQCDKSFRNLSSYSAHKRSHVTNKLFHCYQCAQTFTSLSALCKHQPPLILETYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2C7</accession>
    <name>A0A3P9D2C7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nucleolar protein family A member 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563586.1">
        <property type="nucleotide sequence ID" value="XM_004563529.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D2C7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028352"/>
    <dbReference type="Ensembl" id="ENSMZET00005029254.1">
        <property type="protein sequence ID" value="ENSMZEP00005028352.1"/>
        <property type="gene ID" value="ENSMZEG00005021139.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487410"/>
    <dbReference type="KEGG" id="mze:101487410"/>
    <dbReference type="CTD" id="55505"/>
    <dbReference type="GeneTree" id="ENSGT00390000012563"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060215">
        <property type="term" value="P:primitive hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.300:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="64" mass="7522" checksum="6114186BA5848A00" modified="2019-02-13" version="1">MFLQYYLNENGDRVYTLKKVTPDGEPTSSAHPARFSPDDKFSRHRVILKKRFNILLTQQPKPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D347</accession>
    <name>A0A3P9D347_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">N-terminal E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
            <ecNumber evidence="10">2.3.2.25</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrate and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].</text>
            <dbReference type="EC" id="2.3.2.25"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EC" id="2.3.2.25" evidence="10"/>
    <dbReference type="RefSeq" id="XP_004546667.1">
        <property type="nucleotide sequence ID" value="XM_004546610.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D347"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028764"/>
    <dbReference type="Ensembl" id="ENSMZET00005029672.1">
        <property type="protein sequence ID" value="ENSMZEP00005028764.1"/>
        <property type="gene ID" value="ENSMZEG00005021456.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487815"/>
    <dbReference type="KEGG" id="mze:101487815"/>
    <dbReference type="CTD" id="692325"/>
    <dbReference type="GeneTree" id="ENSGT00940000156908"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000022">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="151" mass="17345" checksum="506B585BBB4CE924" modified="2019-02-13" version="1">MASMQKRLQKELLALQNDPPPGMTLNEKSVQNTITQWIVDMEGAPGTLYEGEKFQLLFKFSSRYPFDSPQVMFTGENIPVHPHVYSNGHICLSILTEDWSPALSVQSVCLSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHDDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D440</accession>
    <name>A0A3P9D440_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-X-C motif chemokine 10</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intercrine alpha (chemokine CxC) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D440"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028851"/>
    <dbReference type="Ensembl" id="ENSMZET00005029764.1">
        <property type="protein sequence ID" value="ENSMZEP00005028851.1"/>
        <property type="gene ID" value="ENSMZEG00005021530.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175443"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00273">
        <property type="entry name" value="Chemokine_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001089">
        <property type="entry name" value="Chemokine_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033899">
        <property type="entry name" value="CXC_Chemokine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00436">
        <property type="entry name" value="INTERLEUKIN8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00437">
        <property type="entry name" value="SMALLCYTKCXC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036468473" evidence="5">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="6">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="85" mass="9465" checksum="FB61F0B0DEF6C0E4" modified="2019-02-13" version="1">MSTIVVALLVFLTIHGASGISPRCQCLFKEKRPIGRFISTVDIYPANSYCKSTEIIATLKKEGQRICLDPNAPWVKQVLKSKKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4D5</accession>
    <name>A0A3P9D4D5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiosulfate:glutathione sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014269653.2">
        <property type="nucleotide sequence ID" value="XM_014414167.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4D5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029433"/>
    <dbReference type="Ensembl" id="ENSMZET00005030361.1">
        <property type="protein sequence ID" value="ENSMZEP00005029433.1"/>
        <property type="gene ID" value="ENSMZEG00005021958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105940826"/>
    <dbReference type="KEGG" id="mze:105940826"/>
    <dbReference type="GeneTree" id="ENSGT00940000165845"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF4">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018160257" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="74"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="176" mass="19718" checksum="06E9629F70FF082C" modified="2019-02-13" version="1">MYLGRVSSCGPVVCIMLSFVLSRSFCQGVTEAHRRCYSTFGSICRTFSTSSPKCEEASDNGSVVTYSELKTMLANHNIQLFDVRNPDEYQAGQIPQAINVPLDNLEESLQLSPELFEQRFEVKAPTKADDNIVFHCRSGIRSTRALSIAHQLGFSKARHFKGGYSEWVEREGKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4F2</accession>
    <name>A0A3P9D4F2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cold shock domain-containing protein E1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent. Interacts with EIF4ENIF1/4E-T.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UNR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4F2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029082"/>
    <dbReference type="Ensembl" id="ENSMZET00005030000.1">
        <property type="protein sequence ID" value="ENSMZEP00005029082.1"/>
        <property type="gene ID" value="ENSMZEG00005021675.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016950"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905172">
        <property type="term" value="F:RISC complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000055">
        <property type="entry name" value="Cold shock domain containing E1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000088">
        <property type="entry name" value="cold shock domain-containing protein E1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000093">
        <property type="entry name" value="cold shock domain-containing protein E1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000094">
        <property type="entry name" value="cold shock domain-containing protein E1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056400">
        <property type="entry name" value="CSDE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12913:SF2">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN E1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12913">
        <property type="entry name" value="UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23456">
        <property type="entry name" value="CSDE1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="130"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="288"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="452"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="633"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="15">
        <location>
            <begin position="788"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="16">
        <location>
            <begin position="863"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="890"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="913" mass="100729" checksum="F2202217A9336F20" modified="2019-02-13" version="1">MGSPWKGFVEFTLPASPPTAFVSADLSSTSPVGLSLSPYGRSHIPVLSPVSEMERGSSEPPVARNTGSTPSASTGPVPIPRSSSVSCHPHPGSKKHKRTPLYQRSMSFDPGMLHNNGHTAYANGSGPGIRETGVVEKLLTSYGFIQCSERQARLFFHCSQYNGNLQELKIGDDVEFEVSSDRRTGKPIAVKLLKIKPEVLPEERISGQVVSSIPLHLDGKSAPGQVPTGSVCYERNGEVFYLTYTPDDVEGNIHLDTGDKVSFYMETNKHTGAVSARNIQLVKKKQMRCQGVVCATKEAFGFIERADVVKEIFFHYSEFKGDLEALQAGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEQFEGTVVKVIPKVPTKNQNDPLPGRVSVRMGFNDKELPFGEKDTKTKVTLLEGDHIQFNISTDRRDKLERATNIEILPDTFKFTKENREMGVIAAIRDGFGFIKCVDRDARMFFHFSEVLEEGQLHISDEVEFTVVPDMLSAQRNHAVRIKKLPKGTVSFHIQSEQRFVGVVEKEVVGNTAKNISPTKGKEKKKDKGKVVEKESEEGVIAYEDCGVKLTVPYHAKDLEGGSHPQVGDKVEFSINEVKRTGQQSAVSIRVLNRNASGAKRLHGFVAALKDNFGFIETANHDQEVFFHYSEMCGDLDNLDLGDTVEYNLSKGKGNKVSAEKVTKVAAVNGIGEDVGGTVMTGKVIRPIRSVDPSQTEYQGLVEFSEEGGSKVQNYPFGIMSMANKSDCLQKGEQVKFQVCTITQTGQKMACNVVPQRRAMVECVKDQFGFITYEVGDSKKLFFHVKEVQDGLELQTGDEVEFSVVLNQRTGKCSACNVRRVSEGPKPVATPRPDRLVNRLKSITLDDASAPRLVIVRQPRGPDNSKGFNVERKTRQPGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4W3</accession>
    <name>A0A3P9D4W3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BCL6 corepressor</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the BCOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024661106.1">
        <property type="nucleotide sequence ID" value="XM_024805338.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024661107.1">
        <property type="nucleotide sequence ID" value="XM_024805339.1"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005029247"/>
    <dbReference type="Ensembl" id="ENSMZET00005030165.1">
        <property type="protein sequence ID" value="ENSMZEP00005029247.1"/>
        <property type="gene ID" value="ENSMZEG00005021813.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153737"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902254">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021915">
        <property type="term" value="P:neural tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060042">
        <property type="term" value="P:retina morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000032">
        <property type="entry name" value="BCL-6 corepressor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.40">
        <property type="entry name" value="BCL-6 corepressor, PCGF1 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031628">
        <property type="entry name" value="BCOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047144">
        <property type="entry name" value="BCOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032365">
        <property type="entry name" value="PUFD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038227">
        <property type="entry name" value="PUFD_som_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117">
        <property type="entry name" value="AGAP007537-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117:SF8">
        <property type="entry name" value="BCL-6 COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15808">
        <property type="entry name" value="BCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16553">
        <property type="entry name" value="PUFD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BCL-6 corepressor non-ankyrin-repeat" evidence="10">
        <location>
            <begin position="1266"/>
            <end position="1464"/>
        </location>
    </feature>
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        <location>
            <begin position="1554"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1587"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="domain" description="BCL-6 corepressor PCGF1 binding" evidence="11">
        <location>
            <begin position="1692"/>
            <end position="1803"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
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        </location>
    </feature>
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            <begin position="359"/>
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    </feature>
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        <location>
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        <location>
            <begin position="812"/>
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        <location>
            <begin position="856"/>
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        <location>
            <begin position="910"/>
            <end position="1015"/>
        </location>
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        <location>
            <begin position="1140"/>
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            <begin position="1180"/>
            <end position="1205"/>
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            <begin position="1268"/>
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            <begin position="1336"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1478"/>
            <end position="1505"/>
        </location>
    </feature>
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            <begin position="244"/>
            <end position="256"/>
        </location>
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            <begin position="266"/>
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            <begin position="297"/>
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            <begin position="378"/>
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    </feature>
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            <dbReference type="Pfam" id="PF16553"/>
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            <dbReference type="Ensembl" id="ENSMZEP00005029247.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
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    <sequence length="1825" mass="198935" checksum="1EB2B3502A533E02" modified="2019-02-13" version="1">MVDARLTPLAAMGLDRSTLLHDGLHLHGGVVYPGIRALQAEKGREAPALPLTYNRDGLPELIYKPDGPLDSRKTANGYLGLYKGAHPSLHKPVLVPGAEGLGLERRVGPGEKASELGLASAGGSYLRMPWLSPYPEASMYPFMDTSKYAALSMYKASLLSQPNPYLPQHLAYPSLCAAQGGSVTPAAAVSAADRLYYMPPYPASPISSPLVAPPMRIPAVTVAPTSLVHCQDKGLGVAPPFAQQLHQPSPLSQHHQASIDRDRSPNRSIRPSRPPSRKGSSNNINTSSIITSGISSLPTDSSPRVSSRLPQPPLPPALIDNSLDLQRPVARIGQPVSSTSSISASSTSAQSIPLTFSVSSMASEQPSPARPSPHKSRPRDGAPEPRNAGVEKRPSRSPSKASSERPAHQPQATKDPAEKPLDLSGRMLDFGLPSNGFPVKMDTSGPRYGLPPNRELLKENLSPSPHPHCVVSSTSSKVSDRPEMISTLHSTWVVPSPSPSHAQHTPGLPTSPRPNTDLGLSQTKGSSPSVIKNKGLERVLPQQRSSSCPRIEEPNHSSTQPSGTSVVNSRALSPKHNGEWVKHSPSQSEPPPAAGHHREGTEKPSQTSKRAETTPDVPSYKRHCVENGHPPGHLYLPQNEAYLNHSLAYANRYLPYPITDNMTIHSVPIGGKGPVYPHPVLLGSNSLYPTHLAAKHPLPYHNLPGPGGEYLTYNSQEMAHPLMQTHSDNKLAERADATLKSRGQEKSRGTVEEGGSHRDNNSGKEIGEGNQMKPDREAGAQGQCGSQSKHPSSSLTSREKIVCIDLVHSDTDMETTPSGHKQHSAETSTKASQNECYHSNQNLTKTEYEPKHHLSLPYPIHSRQSPNLKPNHSDRQPEAPFGRAEVPQDTGCAGATSSISPASPCLVAQAEESCEEQSPSPDLEDQDQSTLRCARTSGERSSGRDKGDRGDSRISRLTQHCTDMVKKSDLEKVPKRETEKEDSIVDLGESQGEGDEEEDGSQTSSKNSRRSSLAKRIANSSGYVGDRFKCVTTELYADSSKLSREQRALQMEVISREGSNISQPAANWERAMMRFSELELKEKEGSGVCMTASAAGRELADGQCGERVLEYCQHTTRQGEREGVRPAYTNNRVPVLQRCGGQREPLSHPHEAQDGARGPGQGGLKDGVRKGMKECEEGHCMPPTLTPSKGFPDERTSPGFGVTRKRPLGLKAEDEDTEMEGERVIHLEKRAKLCTDEREKASADDDDDEEVRKLKVCIELKGLRLSKPAAGAASPDGSQIKQERAWPQPRLVSPTQGLRERKIRPGEHEDRAAAQRSEINRKWGCEKLPNGVAAAVAPLPPSQLKDRAHPPNPFSGDRGLKESRRGPPSPAPEQSVGGTPPLKVRRHSDTDKPKGKRPCKTKHTSQREREREREKRKEAAASSPGQRCGTELGKAEDDKLSEQCSAPRKRAASPNHYPCSPVKPCSPTALCPPSLQLQANDRAGGVPPEPAGLHRTPPAEPSVVRPIPPEARRLIVNKNAGETLLQRAARLGYEEVVLYCLENRVCEVNHRDYAGYCALHEACARGWLTIVQHLLDYGADINCSAQDGTRPIHDAVENDHLDVVRVLLSYGADPTLATYSGRGLLKMTHSDSMERFLTDYFADLQGRSDDDPGLYWEFYGSAVCESTEEGGVYDILADAPGPDDEDEDDKREVFEFEFSDRPLLPCYNIQVSLSQGPKNWLLFSDVLRRLRMSARGFRQAFPHMEVVTVAEAEFYRQASLSQLFSCPEELEGFHPDSKELLDLVEDSAELAALLGSTLEFLDDRWDHPGEKLKDKIKAVEKLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D5Q9</accession>
    <name>A0A3P9D5Q9_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">PB1 domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="342" mass="38917" checksum="C81A95BA1E401CDD" modified="2019-02-13" version="1">MAGSTPARLKVILGENNIEKLTLPNGIPESLEDLLSTIKTTFGLKGNFRLQYMDQDFGNDFFNLNSTTELRNLGTIKVIHQQTNPPLISADQSTSSLSLSFESDDGISVASNDTIILSSPESMSSRTQQWPEDFAIPQFSYDTELQLERGNTEYRVSQKMLTLSARMLSDILKRVAEEIYRYKAYPEDAHFCAAAEALIKKHPCLKEPGSFNGCYGWKQRLKYKMANYRTQLKLQGLCVNSLKSKATTDAFPAKKVKKPKRSEANFYPSFPTGETLDSMEKVRLELLTEIGIRDNERVIADKMANTFAYRRHEVVNQEPSIQELKDRWPALFTQKEVRMELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D667</accession>
    <name>A0A3P9D667_9CICH</name>
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        <submittedName>
            <fullName evidence="16">RAR-related orphan receptor A, paralog a</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE). Required for proper cerebellum development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D667"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030078"/>
    <dbReference type="Ensembl" id="ENSMZET00005031025.1">
        <property type="protein sequence ID" value="ENSMZEP00005030078.1"/>
        <property type="gene ID" value="ENSMZEG00005022429.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157387"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06968">
        <property type="entry name" value="NR_DBD_ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06939">
        <property type="entry name" value="NR_LBD_ROR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000005">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000003">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044101">
        <property type="entry name" value="NR_DBD_ROR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003079">
        <property type="entry name" value="ROR_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF3">
        <property type="entry name" value="NUCLEAR RECEPTOR ROR-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01293">
        <property type="entry name" value="RORNUCRECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="268"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="509" mass="56835" checksum="83F52F1630126463" modified="2019-02-13" version="1">MESPPDPASDPGNSASEPATPVRETPVNLETLRKADHPAPVRRQTCSSTNRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAAYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRLQQQQRDHQQQPGEAEPLTPSYGLSASGLTELHDDLSGYMDGHTPDGSKPDSAVSSFYLDIQPSPDQSGLDINGIKPEPICDFAPGSGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHMETCQYLREELQQMTWQAFLQEEVESYQNKPREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFVRMCRAFDTQNNTVYFDGKYAGPDVFKSLGCDDLISSVFEFGKNLCSMHLSEDEIALFSAFVLMSADRSWLQEKVKVEKLQQKIQLALQHVLQKNHREDGILTKVQCIQNTLHPLSPKAGIPCCCSNLILHCLGSLSTGLETFLTPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6X3</accession>
    <name>A0A3P9D6X3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Annexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6X3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030099"/>
    <dbReference type="Ensembl" id="ENSMZET00005031046.1">
        <property type="protein sequence ID" value="ENSMZEP00005030099.1"/>
        <property type="gene ID" value="ENSMZEG00005022444.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154257"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004859">
        <property type="term" value="F:phospholipase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000003">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000007">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002389">
        <property type="entry name" value="ANX2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF18">
        <property type="entry name" value="ANNEXIN A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00198">
        <property type="entry name" value="ANNEXINII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0041">Annexin</keyword>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 11" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="330" mass="37027" checksum="8964BD87A28C431E" modified="2019-02-13" version="1">MAMVSEFLGQLSLNIGGQDPLFPTVVPAPDFDPDKDAARIETAIKTKGVDEQTIIDVLTKRTYAQRREIAFAYERRAKKDMISALKGALSGSLETVILGLMKSTAQFDASEIKASIKGLGTDEETLIEILCSRSNDELVEIKKVYKELFKKELDKDVAGDTSGNFAKLLLALVQTKRAEPSSITDYEKIDEDARALYDAGIKIKGTDVATWISIMSERSVPHLQKVFQKYKSYSPYDMQESIVKEVKGDLQTSFLVLVQCFENKQLYFAKRLNEAMKSKGAKEKMVTRIIVSRCEVDLRKICSEYKSCFGQSLQQTIMASEFSNLPLVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7Y4</accession>
    <name>A0A3P9D7Y4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SKI family transcriptional corepressor 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553112.2">
        <property type="nucleotide sequence ID" value="XM_004553055.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7Y4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030469"/>
    <dbReference type="Ensembl" id="ENSMZET00005031430.1">
        <property type="protein sequence ID" value="ENSMZEP00005030469.1"/>
        <property type="gene ID" value="ENSMZEG00005022702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484245"/>
    <dbReference type="KEGG" id="mze:101484245"/>
    <dbReference type="CTD" id="567457"/>
    <dbReference type="GeneTree" id="ENSGT00940000158440"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21080">
        <property type="entry name" value="DHD_Skor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.390.10:FF:000001">
        <property type="entry name" value="SKI family transcriptional corepressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000003">
        <property type="entry name" value="SKI family transcriptional corepressor 1 homolog-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF8">
        <property type="entry name" value="SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="9">
        <location>
            <begin position="135"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="664"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="746" mass="83136" checksum="113B3765865EE1FC" modified="2019-02-13" version="1">MDSIPAGRDSTSSPNSKQELSYPSTNLKPNQVGETVLYGIPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGAHSPPKLPENFAFDVSHECAWGSRGSFIPARYNSSRAKCIKCSYCNMYFSPNKFIFHSHRTPESKYTQPDAANFNSWRRHLKLTDKGSAMEILHAWEDVKAMFNGGSRKRTLPGSGSGSSSPLKSHEPSRPQSSPEIPAKILSCEGSRGAMTSTRSYPVIPVPSKGFGIMQKIPPPLFPHPYGFPAFGLCQKKEDGMMGEQSKGGLPGVLWPATKDSAYHSFPMFWPAAGALPMPPYPQTHHKPPPELLCPPRQTDMDMSEHSDRSTNTSKDSAVDNDRCSSTQSLRNEEDKSGDEGRPAEGVPLQPRKISYVSAFRPVIKDADCIAKLYGNRSAYNGCRTGYLSPDFLSESSSYRSVSPCVDSEGEPDVDVETNKTQDEEEEEGSRPLSSVCPRTPLALTHTVSPHDSDSKGLQESSLVDSQKTSLHVAQSSERELQTKQLSESHIAAPFTEVYTPERSELQQRSSPYQFRAANYPPGVGLLTTNDESASKEEPSSTVEEIETKSFNEQSSEEHQREPDEGEDAPPRALPTQRDIQSLAKEELQKQLLEQVELRKKLEREFQHLKDNFQDQMKRELSYREEMVQQLHIVREAHDALHHFSCKMLTPRHCTGSCSFKSPLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8X3</accession>
    <name>A0A3P9D8X3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 25</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552537.1">
        <property type="nucleotide sequence ID" value="XM_004552480.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004552538.1">
        <property type="nucleotide sequence ID" value="XM_004552481.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8X3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031155"/>
    <dbReference type="Ensembl" id="ENSMZET00005032160.1">
        <property type="protein sequence ID" value="ENSMZEP00005031155.1"/>
        <property type="gene ID" value="ENSMZEG00005023234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479340"/>
    <dbReference type="KEGG" id="mze:101479340"/>
    <dbReference type="CTD" id="81857"/>
    <dbReference type="GeneTree" id="ENSGT00940000160439"/>
    <dbReference type="OrthoDB" id="7690434at2759"/>
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        <property type="component" value="LG4"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:roof of mouth development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 25"/>
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        <property type="entry name" value="Mediator complex subunit 25, ACID domain"/>
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    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12433:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25"/>
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    <dbReference type="Pfam" id="PF11232">
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="295"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="616"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009102"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019694"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU369088"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="742" mass="79642" checksum="6A09DD26782D5B12" modified="2019-02-13" version="1">MVAGSALMEPSSKPGPNQVADVVFVIEGTANLGPYFESLRKNYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDNIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADSLVKIIRDRGINFSVVAPRKLPPLRALFERASPVGGAVESLPDYSQDPFHMVLVRGISLPVSAGGGPGPHKPVIPPPVLASSQPVVGTPQPPPPINTTPPYQNTPLTAAQVAAQMVMEAANNQKSRFPGMGQGPPFPSHPVVKPIQPSLSTVSTVNTPIQPVTPNQQPVPPAGQPVPSQPPQPLPQQPQPSGNQTTQPSAAPTMPGSQVNPNPIPQGQGVTNKVVAWTGVLEWQEKPKASSMDSATKLTRSLPCQVHVNPGENLNTDQWPQKLIMQLIPQQLLTTLGHLFRNSRMVQFLFTNKDVESLKGLYRIMANGFAGCVHFPHTTSPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITSHKQVQQHRAQLNSAAGPMQPNQVPPNQNFINRAPGPIPVSHGNVQQQSVVVGMPPVSQVSMMEEQQRQNNMMTMRAAGPTNQQPPVSGAPPNQVPTSGQAPPQGPILRLTNPGANPQLRSLLLSQQQPQGGVSHMPSMMSHQGLGQQMVHQAPGSGPQMQSQWRQPMTGQMMMSGAQRGAVPQPGMPQVSSMMEDEVLMDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9G1</accession>
    <name>A0A3P9D9G1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized LOC101473490</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9G1"/>
    <dbReference type="Ensembl" id="ENSMZET00005031725.1">
        <property type="protein sequence ID" value="ENSMZEP00005030747.1"/>
        <property type="gene ID" value="ENSMZEG00005022909.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101473490"/>
    <dbReference type="GeneTree" id="ENSGT00940000168504"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
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        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
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        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
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        <property type="entry name" value="SI:DKEY-56D12.4"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00980">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
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            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="450" mass="50611" checksum="BB8F9C4894C47FCB" modified="2019-02-13" version="1">MPQCCVPFCFNYSGSKKNTNLSFHRFPCDEKEKQKWLHAISRLNFTPNCNSRVCSWHFPEGKAAGPTRFAWNEESFHFSDEEKHPVHKKKKEQVPASGENECERSDELHHSNNADTQTATASSSSSSNSLVVLEIENDMLRQENEKLKKQLEKQKQTFSFSQISDNPERVQYYTGLPDTATVLFLESLLSKFELKYHSGWTVQMLPIVDQLLLTLMKLKLDCGHVDLATRFTCSTATVTNIFTTIVSALHDILYVGMLEKNIASRAKNQTSLPDCFQPFPNCRIVLDCTEVSVSGRESRDTQSCLYSQRKGRIILKALIGVAPNGVITFASNLYSGKTSDKAITADCGVLRHLQPGDMVIAGKDFTIQDILPEGVSLNIPSVSGQFAQQEVNNNRLISSARAHVAHSIQRLKRFSILNLVPHQYKKNINKILKVCVCLTNLQTPVIHETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDF5</accession>
    <name>A0A3P9DDF5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Neurotrypsin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DDF5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032181"/>
    <dbReference type="Ensembl" id="ENSMZET00005033222.1">
        <property type="protein sequence ID" value="ENSMZEP00005032181.1"/>
        <property type="gene ID" value="ENSMZEG00005023972.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158131"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000019">
        <property type="entry name" value="Neurotrypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 6" id="KW-0420">Kringle</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kringle" evidence="9">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="82"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="189"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="10">
        <location>
            <begin position="296"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="227"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44340" checksum="567B43A80717B9C9" modified="2019-02-13" version="1">MIRRPSDGGCSSLPPEPQPPSTVPTLQLTFRTRCMNWTEVSGFDERYPGKGIGEHNHCRNPDGRIRPWCFFRNHRGKHAGSVRLQGGRSKLDGRVEVYLGGTWGSICSNDWGDEDATVVCRQLGKGFSGRARAVPLFRPGTAKLHWTAVHCQGKEPDLLQCPKATWNGEECSLVAAVTCNQQPGVSLPIRLVGGRSKSEGRVEVLHAGEWGSICDDQWDDSDAEVVCRQLGLSGVARAWGQAHFGKGSGRLWLDEVRCTGNELTLEQCPKSAWGEHNCLHSEDAGVSCNPLTDGTIRLVGGAGSHEGRLEIFYRGQWGTVCDDGWTNSNTQVVCRQLDTPVPRFGVGLGPILLDDVSCTGKEPSLLLCNRREWLHHDCTHQEDVNIACNPEHNGEGLPISKRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEL0</accession>
    <name>A0A3P9DEL0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GPI-anchor transamidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-glycan biosynthesis class K protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heteropentamer. Part of the GPI-anchor transamidase complex, consisting of PIGK, PIGT, PIGS, PIGU and GAA1. Interacts with GPAA1. Interacts with PIGT; this interaction, via a disulfide link, stabilizes the expression of GAA1 and PIGK and links them to PIGS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DEL0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032602"/>
    <dbReference type="Ensembl" id="ENSMZET00005033660.1">
        <property type="protein sequence ID" value="ENSMZEP00005032602.1"/>
        <property type="gene ID" value="ENSMZEG00005024292.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156273"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000002">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027917031" description="GPI-anchor transamidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="372" mass="42132" checksum="4ECE75E40BE22FC4" modified="2019-02-13" version="1">MKILTLLGLFSACFLANSINIENSAGQFFSSGHTNNWAVLVCTSRFWFNYRHVANTLSVYRSVKRLGIPDSHIVLMLADDMACNHRNPKPATVFSHKNMELNVYGDDVEVDYRGYEVTVENFLRVLTGRLPPSTPRSKRLLSDDRSNILIYLTGHGGNGFLKFQDSEEISNVELADAFEQMWQKRRYNELLFIIDTCQGASMYERFYSPNIMALASSQVGEDSLSHQPDLAIGVHLMDRYTFYMLEFLEDIHPASKTNMNDLFKVCPKSQCVSTPGHRTDLFLRDPGSVLITDFFGSVRKVELTMDAINLTDPIKQMEEDPVNGEEQKEVYSYADQLPVSEIIHQMSLCRFHGDISKCEMQLPPGLGAEGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DF93</accession>
    <name>A0A3P9DF93_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding Raly-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM HNRPC family. RALY subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012775653.1">
        <property type="nucleotide sequence ID" value="XM_012920199.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DF93"/>
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    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF34">
        <property type="entry name" value="RNA-BINDING RALY-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
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    <dbReference type="PIRSF" id="PIRSF037992">
        <property type="entry name" value="hnRNP-C_Raly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="291" mass="32075" checksum="CC9E563A83AB39FA" modified="2019-02-13" version="1">MTGKTQTSNVTNKNDPRSLNSRVFIGNLNTAVVTKADIEAIFAKYGKIVGCSVHKGYAFVQYASERNARAAVAGENARIVAGQSLDINMAGEPKPYRPKMGSKRPLSSLYSGYEFDYDYYRDDFYSRLFEYHGRVVPPTRAVIPIKRSRLVVPTTRRAKSSFPVRACSSSSSSSSSSRALNVGSSITGPKLKTDQLLTIKKELSQIKTKIDSLLGRLEKIERQHRSDAEMQRKQEEVCECLHGDAADHSGGEEVEGTAEVEAGEMTDGGEDDFEDEGTSDMIENHISDIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGC6</accession>
    <name>A0A3P9DGC6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005033222"/>
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        <property type="protein sequence ID" value="ENSMZEP00005033222.1"/>
        <property type="gene ID" value="ENSMZEG00005024794.1"/>
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        <property type="component" value="LG10"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8293" checksum="DA03D79CA7390712" modified="2019-02-13" version="1">MNQDSEKETLCFLSVFSPLTKVKLINELNEREASLGVNESVSWHSEYKDSAWVFVGGFPYELTEGDLICVFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHX7</accession>
    <name>A0A3P9DHX7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium homeostasis modulator family member 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
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            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CALHM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004571386.1">
        <property type="nucleotide sequence ID" value="XM_004571329.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHX7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033787"/>
    <dbReference type="Ensembl" id="ENSMZET00005034973.1">
        <property type="protein sequence ID" value="ENSMZEP00005033787.1"/>
        <property type="gene ID" value="ENSMZEG00005025263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472712"/>
    <dbReference type="KEGG" id="mze:101472712"/>
    <dbReference type="CTD" id="441168"/>
    <dbReference type="GeneTree" id="ENSGT01030000234610"/>
    <dbReference type="OrthoDB" id="5962981at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029569">
        <property type="entry name" value="CALHM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261:SF4">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14798">
        <property type="entry name" value="Ca_hom_mod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="326" mass="36573" checksum="4A511AE3597CD215" modified="2019-02-13" version="1">MDKFKTVLNIAGKQTNLGFGLIALLTAGGEQIFSAVVFKCPCNELNFVYGIVFLLVPALALLLLGYILSKKTWKLLTGLCRRTDKLLCCKKLVAAGVVLCQIGTFALVAPSTWIAVALLNGNYYECAMTGTNVSIYNKHVCRDRNSEIQCEKELHRFPCGKSISVPQAAREDVLLNLRAESQILGWMLITLIMLTNLVLTCVARCSSPISYLQLQFWKAYVHEESNLLDSYTAKHAKAFAERNLKTFFEKTPPENVITPSNRDWEKISSLYKFTSKDTYYSTLHRYVENCQETDNGTMRMSSVKSNESVEDNPAVLSFVDDGRMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DM81</accession>
    <name>A0A3P9DM81_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sorting nexin-27</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004549105.1">
        <property type="nucleotide sequence ID" value="XM_004549048.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DM81"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035519"/>
    <dbReference type="Ensembl" id="ENSMZET00005036775.1">
        <property type="protein sequence ID" value="ENSMZEP00005035519.1"/>
        <property type="gene ID" value="ENSMZEG00005026536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467680"/>
    <dbReference type="KEGG" id="mze:101467680"/>
    <dbReference type="CTD" id="566205"/>
    <dbReference type="GeneTree" id="ENSGT00950000183212"/>
    <dbReference type="OrthoDB" id="10036828at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13338">
        <property type="entry name" value="FERM-like_C_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01777">
        <property type="entry name" value="FERM_F1_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23070">
        <property type="entry name" value="PDZ_SNX27-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06886">
        <property type="entry name" value="PX_SNX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.60:FF:000002">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000061">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000075">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000003">
        <property type="entry name" value="sorting nexin-27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037827">
        <property type="entry name" value="SNX27_FERM-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037833">
        <property type="entry name" value="SNX27_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037835">
        <property type="entry name" value="SNX27_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF20">
        <property type="entry name" value="SORTING NEXIN 27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="43"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="159"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="271"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="563" mass="63784" checksum="8DE388C5F9A4B704" modified="2019-02-13" version="1">MADVGGDETRPVLPSASRNGPVVGSSAGTAGHGAAMVTSGPRMVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGIVKGDRILEVNGVNVEGATHKQVVDLIRAGEKELVLAVLSVPPQEADGLEGGEEVQPNYDYSDKQAVPISIPTYKHVEQHSERFVVYNVYMSGRQLCSKRYREFAILHQNLKREFSNFNFPKLPGKWPFSLSEQQLDARRRGLEEYLERVCSVRVIGESDIMQEFLSESDENYNGVSDVELRIALPDKTTISVRVRKNSTTDQVYQALVMKVGMDSIMASYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLALRKWLFSFQEEELLRDNPLALHYCFHQALDDVKKGFIKTEDKSYQLQKLAEQRKMATYLSLLRTCEGYNEVVFPHCSCDSRRKGHVITAISINHFKLHACTEDGTLENQVIAFEWGEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERIFCELKWRKQVEEEASDKDNKNCSNNEFLPPLETQQKGWRHLGGEIATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DN50</accession>
    <name>A0A3P9DN50_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">A-type voltage-gated potassium channel KCND1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Potassium voltage-gated channel subfamily D member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Voltage-gated potassium channel subunit Kv4.1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of heteromultimeric potassium channels. Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_024806475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DN50"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035864"/>
    <dbReference type="Ensembl" id="ENSMZET00005037129.1">
        <property type="protein sequence ID" value="ENSMZEP00005035864.1"/>
        <property type="gene ID" value="ENSMZEG00005026780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486275"/>
    <dbReference type="KEGG" id="mze:101486275"/>
    <dbReference type="CTD" id="3750"/>
    <dbReference type="GeneTree" id="ENSGT00940000155472"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000016">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000004">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004054">
        <property type="entry name" value="K_chnl_volt-dep_Kv4.1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024587">
        <property type="entry name" value="K_chnl_volt-dep_Kv4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021645">
        <property type="entry name" value="Shal-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF174">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11879">
        <property type="entry name" value="DUF3399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11601">
        <property type="entry name" value="Shal-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01516">
        <property type="entry name" value="KV41CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018158585" description="A-type voltage-gated potassium channel KCND1" evidence="19">
        <location>
            <begin position="17"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="324"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="20">
        <location>
            <begin position="40"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00061375"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00070409"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00075631"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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            <dbReference type="ARBA" id="ARBA00076406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="638" mass="71987" checksum="B8FF6D0EBFBAD527" modified="2019-02-13" version="1">MAAGVATWLPFARAAAVGWLPLAKKTMPKPPVDNSSRSDEILYLNVSGVRFQTWKNTLDRYPDTLLGSSEKEFFFNEDTEEYFFDRDHEMFRHILNFYRTGKLHYPRHECIQAFDEELAFYGIVPEIIGDCCMEEYRDRKKENQERLAEDTEANESMDAPLPPDSTPRERLWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCRPPEGRVKDLPCGEKYQLAFFCMDTACVLIFTFEYLMRLFAAPSRCKFMRSVMSVIDVVAIMPYYIGLVMPENEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTKGSTFTSIPASFWYTIVTMTTLGYGDMVPNTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRMAKKGTTNAFLQYKEDRGLRGRDSDSTALCVKNRSAFEHQHHHLLHCLEKTTNHEFTDEMTYSELCMTESVGFRTSRSTSLSSQQGAQNNPTGCCPRRARRRAAMRLANSTASVSRGSVQELDTLHIKTTSIPPQTRSSLNAQADNLKLNCGEQDFTAAIISIPTPPANTPDESLPPSPAPIPGILRNTRATAFTHETVKISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ43</accession>
    <name>A0A3P9DQ43_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Leucine-rich repeat-containing protein 23</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004558926.1">
        <property type="nucleotide sequence ID" value="XM_004558869.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ43"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036352"/>
    <dbReference type="Ensembl" id="ENSMZET00005037626.1">
        <property type="protein sequence ID" value="ENSMZEP00005036352.1"/>
        <property type="gene ID" value="ENSMZEG00005027118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464809"/>
    <dbReference type="KEGG" id="mze:101464809"/>
    <dbReference type="CTD" id="10233"/>
    <dbReference type="GeneTree" id="ENSGT00940000159748"/>
    <dbReference type="OrthoDB" id="271226at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001051">
        <property type="entry name" value="Leucine-rich repeat-containing 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF47">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="319" mass="36186" checksum="A948D2BBCD2B4672" modified="2019-02-13" version="1">MSDFDEDPVLSDVEGGEEHLKEAEDEKVEVQHLTQEIISEGLSLLCRTGNGLAHAFVKLNLQKRGLEDIAAINSYIHIRFLDLSNNHLTDLSPLSSLTQLLWLKVDNNSVMCFKEQPFAQLTYLQWLSIAMNQLTDVDGLVGPALESLNLTGNHIQRLNGFQYGSFANLVTLELRGNHLETTDGINLPHLQQLYLAQNAIKRLEGLEKLERLTTLHLRDNQLESLDGLSPSMKCLQYLNARGNAIIDETDLRYIGFLSQSLRVLVLSGNPVAENSEYRINVLIVVPQLERLDKNPVFPEERAEAWERIRELQEEEMYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ67</accession>
    <name>A0A3P9DQ67_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox C10a</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004558856.1">
        <property type="nucleotide sequence ID" value="XM_004558799.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ67"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036418"/>
    <dbReference type="Ensembl" id="ENSMZET00005037699.1">
        <property type="protein sequence ID" value="ENSMZEP00005036418.1"/>
        <property type="gene ID" value="ENSMZEG00005027184.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101470732"/>
    <dbReference type="CTD" id="100535576"/>
    <dbReference type="GeneTree" id="ENSGT00940000160855"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="254"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="256"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="147"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="330" mass="36799" checksum="2159F416F4ADBFBB" modified="2019-02-13" version="1">MSCPNNIAPGNFLMDSLMGGSSSFRGDSYSSNPGMYIHSAAEYGYSVMRNSGKVGLSSLSKGDEILTPGGVSLSGFQDEAYLSTQLATWTPGSKTSRDEQPVAQCLQPCSFPMGSVKEEAFCCLYQDDSNKGKQTTESATYIRLGDNSCRPQQTASSSSGCFKVYSGERPPQDGRQFPSSFSLTHLATSVEPSAESTISRSKAKETARELSKTEESQSRKEEKAKSDSCTDISDGELKDDLSAEKTTGSWLKAKSGRKKRCPYTKHQTLELEKEFLFNMYLSRERRLEISRSINLTDRQVKIWFQNRRMKLKKLNRESREREQSAVYNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSE5</accession>
    <name>A0A3P9DSE5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSE5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037056"/>
    <dbReference type="Ensembl" id="ENSMZET00005038348.1">
        <property type="protein sequence ID" value="ENSMZEP00005037056.1"/>
        <property type="gene ID" value="ENSMZEG00005027572.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164068"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF4">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="102"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="11">
        <location>
            <begin position="513"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="637" mass="71804" checksum="4A826852613661E2" modified="2019-02-13" version="1">MQLIWLFTSNTKCFSTFGISQCSSSCSTCLFIPLLCLQQDSCETNMLVWTVCAALIACGVLLRHSSFLQDVQFVLTKIKVRRFIEKCVQTNYSILDRFLELVKTQPHKPFVYFKDETFTYRDADVLSNKVARAFLQAGCVKEGDTVALFLGNQPMFLWLWLGLVKIGCAGALLNSNIRSKSLLHCLNCSGATTLVAAEGSTCISVCFSKQWRQCEVTGVKSFIDKMNQASSEPIPKELRSHLTMQSPAAYIYTSGTTGLPKAALITQGRVWTMSLLLPSSGVNSKDVIYDTLPLYHSTGFLVFTGAIERGIPVVLRSKFSASQFWDDCEIMRYLCNTPQKLTDKNHKVRLAVGNGIRADVWRDFVRRFGEIQIREFYGATEGNFALLNYSSKMGALGRHTFLHKVKMFFPYAVIKYDIDKEEPLRDSSGFCMEVQRGEPGLLVTKITAKAPFIGYVRDMKQTEKKKLRNVFKKGDLYFNTGDLLRIDEDNFMYFHDRVGDTFRWKGENVATAEVADILALADCIKEANVYGVKVPGQEGRAGMAAVTLRDGLKFDSTAVFKHVEDFLPSYARPRFLRIQRSLDITGTFKLIKTKVVEQGFNPNEITDPLYFLNEKEKNYTPLTPDVFDSIIAGDVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTK8</accession>
    <name>A0A3P9DTK8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTK8"/>
    <dbReference type="Ensembl" id="ENSMZET00005038772.1">
        <property type="protein sequence ID" value="ENSMZEP00005037466.1"/>
        <property type="gene ID" value="ENSMZEG00005027941.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000193381"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12893">
        <property type="entry name" value="SPRY_PRY_TRIM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="8">
        <location>
            <begin position="275"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
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            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="488" mass="56347" checksum="7C8252EC0669844F" modified="2019-02-13" version="1">MEMKCYLEESEEDLCCPVCREVFRDPVILSCSHSFCKDCLKRWWRERPTHECPVCKRRSSKDDPPLNLALRNLCESFLQERDQRASEALCSLHSEKLRLFCLDHQQPVCVVCCASEKHTNHRFRPIDEAAQQHKKELQETLEPLKKKLKVCEEVQVKFDQTAEHIKVQARHTERQIKEQFKKLQQFLAEEEEARLAALREEEEQKSVMMKEKMEALSREIAALSDTVRATEEELRAEDVSFLHNYKAAVERVQRCPLLDDPQLPSGALIDQAKHLGNLTFNIWNNMKDVVSYTPLILDPNTAHPELILSEDLTSVRRGGEKQQLPDNPERIDYSSSVLGSEGFNSGTHSWDVEVGDSIGWLVGVLAESVKRKGDKLSGLWRIRFYQDKYLALSPSAGVTALSVKKKLQRIRVNLDWNRGKLSFSDPDTNTHIHTFTHTFTHRLFPYIWTVDKVKVCPLKVSAKLSLLISLYIPTAYSIRKQSKQQIKH</sequence>
</entry>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
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                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <location evidence="2">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
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        <source>
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        <citation type="submission" date="2005-06" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative Phylogenetic Analyses of the Adaptive Radiation of Lake Tanganyika Cichlid Fishes: Nuclear Sequences are Less Homoplasious but also Less Informative than Mitochondrial DNA.</title>
            <authorList>
                <person name="Clabaut C."/>
                <person name="Salzburger W."/>
                <person name="Meyer A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2007" name="Proc. R. Soc. B" volume="274" first="1867" last="1875">
            <title>Do constructional constraints influence cichlid craniofacial diversification?</title>
            <authorList>
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                <person name="Mims M.C."/>
                <person name="Streelman J.T."/>
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            <dbReference type="PubMed" id="17519189"/>
            <dbReference type="DOI" id="10.1098/rspb.2007.0444"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">2291</strain>
        </source>
    </reference>
    <reference evidence="97" key="3">
        <citation type="journal article" date="2010" name="J. Evol. Biol." volume="0" first="0" last="0">
            <title>Comparative rates of lower jaw diversification in cichlid adaptive radiations.</title>
            <authorList>
                <person name="Hulsey C.D."/>
                <person name="Mims M.C."/>
                <person name="Parnell N.F."/>
                <person name="Streelman J.T."/>
            </authorList>
            <dbReference type="PubMed" id="20456574"/>
            <dbReference type="DOI" id="10.1111/j.1420-9101.2010.02004.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2010" name="Mol. Ecol." volume="19" first="940" last="951">
            <title>Geography disentangles introgression from ancestral polymorphism in Lake Malawi cichlids.</title>
            <authorList>
                <person name="Mims M.C."/>
                <person name="Darrin Hulsey C."/>
                <person name="Fitzpatrick B.M."/>
                <person name="Todd Streelman J."/>
            </authorList>
            <dbReference type="PubMed" id="20149093"/>
            <dbReference type="DOI" id="10.1111/j.1365-294X.2010.04529.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Ch252z</strain>
            <strain evidence="23">Ch258z</strain>
            <strain evidence="24">Ch263z</strain>
            <strain evidence="25">Ch267z</strain>
            <strain evidence="26">Ch269z</strain>
            <strain evidence="27">Dm1406z</strain>
            <strain evidence="28">Dm1422z</strain>
            <strain evidence="29">Dm1424z</strain>
            <strain evidence="30">Dm1462z</strain>
            <strain evidence="31">Dm1464z</strain>
            <strain evidence="32">Dm1466z</strain>
            <strain evidence="33">Dm1470z</strain>
            <strain evidence="34">Dm1472z</strain>
            <strain evidence="35">Ec605z</strain>
            <strain evidence="36">Ec614z</strain>
            <strain evidence="37">Ec618z</strain>
            <strain evidence="38">Ec624z</strain>
            <strain evidence="39">Ec635z</strain>
            <strain evidence="40">Ec642z</strain>
            <strain evidence="49">Mg780z</strain>
            <strain evidence="50">Mg782z</strain>
            <strain evidence="51">Mg784z</strain>
            <strain evidence="52">Mg785z</strain>
            <strain evidence="53">Mg786z</strain>
            <strain evidence="54">Mg788z</strain>
            <strain evidence="41">Mj846z</strain>
            <strain evidence="42">Mj848z</strain>
            <strain evidence="43">Mj850z</strain>
            <strain evidence="44">Mj852z</strain>
            <strain evidence="45">Mj854z</strain>
            <strain evidence="46">Mj856z</strain>
            <strain evidence="47">Mj859z</strain>
            <strain evidence="48">Mj861z</strain>
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            <strain evidence="65">Mu1524z</strain>
            <strain evidence="66">Mu1526z</strain>
            <strain evidence="67">Mu1528z</strain>
            <strain evidence="68">Mu1530z</strain>
            <strain evidence="55">Mz1611z</strain>
            <strain evidence="56">Mz1613z</strain>
            <strain evidence="57">Mz1615z</strain>
            <strain evidence="58">Mz1619z</strain>
            <strain evidence="59">Mz1628z</strain>
            <strain evidence="60">Mz1631z</strain>
            <strain evidence="69">Ot33z</strain>
            <strain evidence="70">Ot35z</strain>
            <strain evidence="71">Ot39z</strain>
            <strain evidence="72">Ot43z</strain>
            <strain evidence="73">Ot45z</strain>
            <strain evidence="74">Ot47z</strain>
            <strain evidence="75">Ot49z</strain>
            <strain evidence="76">Ot54z</strain>
            <strain evidence="77">Tw1217z</strain>
            <strain evidence="78">Tw1237z</strain>
            <strain evidence="79">Tw1245z</strain>
            <strain evidence="80">Tw1312z</strain>
            <strain evidence="81">Tw1319z</strain>
            <strain evidence="82">Wt952z</strain>
            <strain evidence="83">Wt954z</strain>
            <strain evidence="84">Wt968z</strain>
            <strain evidence="85">Wt970z</strain>
            <strain evidence="86">Wt973z</strain>
            <strain evidence="87">Wt979z</strain>
            <strain evidence="88">Zi1066z</strain>
            <strain evidence="89">Zi1069z</strain>
            <strain evidence="90">Zi1071z</strain>
            <strain evidence="91">Zi1073z</strain>
            <strain evidence="92">Zi1076z</strain>
            <strain evidence="93">Zi1078z</strain>
            <strain evidence="94">Zi1080z</strain>
            <strain evidence="95">Zi1082z</strain>
            <strain evidence="96">Zi1084z</strain>
        </source>
    </reference>
    <reference evidence="102" key="5">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="98" key="6">
        <citation type="journal article" date="2015" name="Mitochondrial DNA" volume="1-2" first="0" last="0">
            <title>The complete mitochondrial genome of the Metriaclima zebra.</title>
            <authorList>
                <person name="Chen X."/>
                <person name="Song X.L."/>
                <person name="Chen L.Y."/>
                <person name="Li Y."/>
            </authorList>
            <dbReference type="PubMed" id="26273916"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="99" key="7">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Hoefler B.C."/>
                <person name="Straight P.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="100" key="8">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Song W.-J."/>
                <person name="Kurnit D.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="101">2J1</strain>
        </source>
    </reference>
    <reference evidence="100" key="9">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="14363" last="14363">
            <title>Ancient hybridization fuels rapid cichlid fish adaptive radiations.</title>
            <authorList>
                <person name="Meier J.I."/>
                <person name="Marques D.A."/>
                <person name="Mwaiko S."/>
                <person name="Wagner C.E."/>
                <person name="Excoffier L."/>
                <person name="Seehausen O."/>
            </authorList>
            <dbReference type="PubMed" id="28186104"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="101">2J1</strain>
        </source>
    </reference>
    <reference evidence="102" key="10">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the complex I subunit 2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ABQ81908.1"/>
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        <property type="protein sequence ID" value="ACZ73048.1"/>
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    <sequence length="348" mass="37794" checksum="E5EE7CF3A12752EE" modified="2006-01-24" version="1">MNPYILAILLFGLGLGTTITFASSHWLLAWMGLEMNTLAIIPLMTQHHHPRAVEATTKYFLTQATAAATLLFASVTNAWLTGQWEIQQITHPLPSTMITLALALKIGLAPLHAWLPEVLQGLDLTTGLILSTWQKLAPFALILQLQPSSSTLLIILGLTSTLIGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSITLLTLLTYFIMTFSTFLVFKLNESTNINTLATSWAKAPALTALMPLILLSLGGLPPLTGFMPKWLILQELTKQGLAPTATLAALSALLSLYFYLRLSYAMTLTISPNNLTGSTPWRLPSTQLTYPLATSTAMTICLLPLTPAISALLTS</sequence>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="Hamartin"/>
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        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27387" checksum="C2E1C31100EB6551" modified="2019-02-13" version="1">MSREQASISELLLSLDSSELQEAERVRAAVNQQLRGAVLSSVVEYYLDSSSSQALLLLSSIREPHHKVLLEKLNESVSRSGTRLGALTLLGHLIRKQPPWVHHISRSPLLLSLLRCLKTDSDVVVLITGVLVLVTLLPMIPQAGKQHINDFFDVFGRLASRSCKNPGHEPVAHLVHLHAGTYSLFHRLYGMFPCSFISYLRLHYSMKENLDTFQEVVKPMLEHVRIHPELVTGTQDYELDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARF3</accession>
    <name>A0A3P9ARF3_9CICH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARF3"/>
    <dbReference type="Ensembl" id="ENSMZET00005000041.1">
        <property type="protein sequence ID" value="ENSMZEP00005000017.1"/>
        <property type="gene ID" value="ENSMZEG00005000041.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000180102"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="124" mass="13795" checksum="0EC0551F5687E20B" modified="2019-02-13" version="1">MLMPKARTCYSPTVTKQSVVRCLREHKDFIIVTTAPINRPSVFRPSNCNVCLRVLILPGSYVSTGPGNQTQQRTVNTAGVMWEEGYMFYMAMVSSGESDITAGSVKKRELLVLTQEHQAGGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AS42</accession>
    <name>A0A3P9AS42_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Signal transducer and activator of transcription</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_023008139.2">
        <property type="nucleotide sequence ID" value="XM_023152371.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AS42"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000535"/>
    <dbReference type="Ensembl" id="ENSMZET00005000600.1">
        <property type="protein sequence ID" value="ENSMZEP00005000535.1"/>
        <property type="gene ID" value="ENSMZEG00005000441.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476764"/>
    <dbReference type="GeneTree" id="ENSGT01050000244905"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060337">
        <property type="term" value="P:type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060333">
        <property type="term" value="P:type II interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000012">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3310:FF:000002">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3310">
        <property type="entry name" value="signal transducer and activator of transcription 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.532.10">
        <property type="entry name" value="STAT transcription factor, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038295">
        <property type="entry name" value="STAT1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022752">
        <property type="entry name" value="STAT1_TAZ2-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036535">
        <property type="entry name" value="STAT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013799">
        <property type="entry name" value="STAT_TF_prot_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12162">
        <property type="entry name" value="STAT1_TAZ2bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02865">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00964">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48092">
        <property type="entry name" value="Transcription factor STAT-4 N-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15 19" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 19" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18 19" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="16 19" id="KW-0804">Transcription</keyword>
    <keyword evidence="12 19" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SH2" evidence="20">
        <location>
            <begin position="571"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="764" mass="88126" checksum="1E901CDCBE037A47" modified="2019-02-13" version="1">MAQWGQLQMLDSKYLEQVDQLYDDSFPMDIRQYLSKWIESIDWDTVAMQDSLATVRFHDLLAQLDDQHSRFALENNFLLQHNIRKIKRNLQDRFQEDPVHMAMIISRNLKEELKILEIAKSTEDETDGAVSAMVVEKQKLDNKVKEMKHIVQVVDQNIKNVEDLQDEYDFKVNTLKNRENEMNGMTVKDLEKEKMTVGRMCFELKAKRQDAVLGLNELLNVTQALLAELISEELPDWKQRQKIACIGGPPNACVDQLQNWFTAVAESLQQVRQHLKKLQELEQKFTYENDPITLKKAYLEGRALELLKNLLSNSLVVERQPCMPTHPQRPLVLKTGVQFTVKLRFLVKLQEFNYQLKVKALFDKDVTEKKGFRRFNILGTNTKVMNMEESNGSLAAEFRHLQLKEQKGPGNRTNDGPLIVTEELHSLSFESELQLNQSGLDIKLEAISLPVVVISNVCQLPSGWASILWYNMLTTEPKNLKFFLSPPAAKWSQLSEVLSWQFSSVTKRGLNQEQLNMLADKLLGTKAQRNPEGLIPWTKFCKQSANEKAFPFWLWIEGILDLIKRHLLSLWNDGCIMGFISKEREKALLTDKCPGTFLLRFSESSREGAITFTWIEHDVHDKPVFHSVEPYTKKELSAVSLPDIIRTYKVMAAENIPENPLRFLYPNIPKDKAFGKYYPKPSEAAEPMEFEDTDKTGYMKTELISVSEVHPSRLQDNMMPMSPDDYKALEQYVSPRDIDAVANNLLDLEDFDHQMSAADFRDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASC2</accession>
    <name>A0A3P9ASC2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Sterol regulatory element-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Sterol regulatory element-binding transcription factor 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation.</text>
    </comment>
    <comment type="function">
        <text evidence="25">Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="27">Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with CEBPA, the interaction produces a transcriptional synergy. Interacts with LMNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="28">Forms a tight complex with SCAP, the SCAP-SREBP complex, in the endoplasmic reticulum membrane and the Golgi apparatus. Interacts with PAQR3; the interaction anchors the SCAP-SREBP complex to the Golgi apparatus in low cholesterol conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">COPII-coated vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the SREBP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASC2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000292"/>
    <dbReference type="Ensembl" id="ENSMZET00005000349.1">
        <property type="protein sequence ID" value="ENSMZEP00005000292.1"/>
        <property type="gene ID" value="ENSMZEG00005000234.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159156"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18921">
        <property type="entry name" value="bHLHzip_SREBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000016">
        <property type="entry name" value="Sterol regulatory element-binding transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062:SF2">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BHLH" evidence="30">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="73"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="412"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="977"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="977"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00039749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00042215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00045313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00045371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1136" mass="121881" checksum="13D89FF8CE1853C3" modified="2019-02-13" version="1">MNSLSFDDHSLDNLDPTLSLNDPSDIDTALLSDIDDMLQLISNQDMEFGGLFDVPPYTTAPPIQEIHGLTQTITSASPPTTTTTPPSSSSILSSNPHLDALLGPPITRSSSSPDKAFQPPTFQQSPLAQAASPNGSPGPNPAFSSTPQALFTSPAPQTPPQTQTQPQARTNYSSPNSYTAGSPSSVSTPATSLSSSPPSIQPVAIQAQLQGLTTASPLLTTSTSPPVQTVAAHVQQVPVLLQPQFIKAESLLLTTLKPDPCMVTTVASPTSLATTTPAQSTSLQAFMGGGTFLTTVPVMVDAEKLPINRIAISGKPAGQPHKGEKRTAHNAIEKRYRSSINDKIMELKDLVAGTDAKLNKSAVLRKAIDYIRYLQQTNQKLKQENMTLKMAAQKNKSLKDLVAMEVDGQADVKSELPTPPASDVGSPTSFSHCGSDSEPDSPMGEDTKPNIGTPDQSTAGGSAVGMLDRSRMALCAFTFLFLSLNPLAALFCSSGSSSSGNTEAVSTHHAGRTVLGVDVAADSWGWMDWMLPTILVWLLNGILVSGVLIRLLVYGEPVTRPHSGSSVLFWRHRKQADLDLARGDFAQASHNLWTCLKALGRPLPTSQLDLACAALWSLLRFCLQRLWVGRWLAARAGGLRADRPLQEDACKSSRDAALVYHRLHQLHMTGKLNGSHLSAVHMSLSAVNLAECSGSCLPVASLAEIYVSAALRVKASLPRVLHFTSRVFLSSARQACLSSSGSVPPAMQWLCHPLGHRFFVDGDWAIRSTPKESIYSQAGNTVDPLAQVTQAFREHLLEKALYCVAQPRGEKNTSPGDGEYADALEYLQLLINASDAAGATSQSFAIGSNMATVTGCDPHSKWWSSITVVIINWLQGDDAAAERLYPTVEHLPRSLQNAESLLPKACLNTFRAVRALLSKPENCQLSLSYSDKASTLLRDSLNLGPHCHSSSLDKVVQLLLCDLLLVMRTNVWRLQQQGATPTGQGSAGTSGPAGIQQASPPELVGFQQDLSSLRKLAQSFRPAMRRLFLHEATARLMAGASPTRTHQLLDRSLRRRATPGAKTEECEMRPGQREQAEAVMLACRYLPPSFLSAPGQRVGMLADAARTLEKLGDKRTLHDCQQMIIKLGSGTTVTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AX74</accession>
    <name>A0A3P9AX74_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AX74"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002032"/>
    <dbReference type="Ensembl" id="ENSMZET00005002131.1">
        <property type="protein sequence ID" value="ENSMZEP00005002032.1"/>
        <property type="gene ID" value="ENSMZEG00005001615.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271858"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF170">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="232" mass="25680" checksum="E20C0D889595B57B" modified="2025-10-08" version="2">MSGLLLQHFGLAEGFSVNCLRIVLIGKTGCGKSSTGNTILGNDKFIAASSQMSVTTYCTKAEGEVDGRPVVVVDTPGLFDTALSNEEVREELVKCISQLAPGPHVFLVVIGVGRFTAEERETIRLTKRFFGKNSEKFTIILFTRGDDLERQGESIDDYIKNKCHDSFKKLISNCGGRYHVFNNSDKQNRTQVSELIAKIDTMVKDNGGSFYTNEMLQEYLSKPKDCLVELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZE1</accession>
    <name>A0A3P9AZE1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Perilipin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554437.1">
        <property type="nucleotide sequence ID" value="XM_004554380.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZE1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002842"/>
    <dbReference type="Ensembl" id="ENSMZET00005002958.1">
        <property type="protein sequence ID" value="ENSMZEP00005002842.1"/>
        <property type="gene ID" value="ENSMZEG00005002224.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469192"/>
    <dbReference type="KEGG" id="mze:101469192"/>
    <dbReference type="CTD" id="123"/>
    <dbReference type="GeneTree" id="ENSGT00950000182920"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.170">
        <property type="entry name" value="Perilipin, alpha-beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF25">
        <property type="entry name" value="PERILIPIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="434" mass="47288" checksum="B5B8F714B340EEEA" modified="2019-02-13" version="1">MATAEVIPTQSVVERVASLPLISSTYGLVSSVYSSTKDNHPYIKTVCEAAEQGVRTITSVALTTASPIIDKLEPQIAMANDLACKGLDKIEKTLPILHQPSEQIVSNAKDVVTTAKDVVTGTVSDTLTSVVEKTRGAVHGGVDKTKSVVNGSVSTVLESRVARLISSGVDTALSTSESLVEQYLPMTEAELELEAKTVKSFDNKEPNYYVRLGSLSTKLRKRAYSRAMVQIRDRKQRCMEFISELNSTVDLIEVGRKNIDSANQMVNKKLNSLVAWKSSSPNQENCHEAEVIESRTLTLARSLTQQLQTTCLVLVSSLQGLPNHIQQEALSLGYSASQVYANFSKAKALGDLPDTGLTSSRVQLSKMKESLDNVMDYLINNTPLNWLVGPFYPRMAPEPTPIPASEDSSTYTTSSSSSTQGQREEPMEVEMESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZT0</accession>
    <name>A0A3P9AZT0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Asparagine-linked glycosylation protein 1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Beta-1,4-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004556468.2">
        <property type="nucleotide sequence ID" value="XM_004556411.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZT0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003185"/>
    <dbReference type="Ensembl" id="ENSMZET00005003313.1">
        <property type="protein sequence ID" value="ENSMZEP00005003185.1"/>
        <property type="gene ID" value="ENSMZEG00005002474.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101470141"/>
    <dbReference type="CTD" id="56052"/>
    <dbReference type="GeneTree" id="ENSGT00390000008647"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03816">
        <property type="entry name" value="GT33_ALG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000096">
        <property type="entry name" value="ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000109">
        <property type="entry name" value="Chitobiosyldiphosphodolichol beta-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018319229" description="Chitobiosyldiphosphodolichol beta-mannosyltransferase" evidence="20">
        <location>
            <begin position="31"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="21">
        <location>
            <begin position="299"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="489" mass="54461" checksum="37B3ABC1BCD3EDD0" modified="2019-02-13" version="1">MAPRCSCTALLAVSLTVLALLAGLLAPHSAVRWPAVSLAVAAALLPLWGRSLRRRDDGTSRRVCVLVLGDIGRSPRMQYHALSLSKHGYHVTFVGFSETKPHQDVLSEEKITIVPIAELKGVRVGPKVVSYVTKVTVQSLQLLRVLLTMELQAHVLMQNPPGLPSIAVTWFVCLLRGSRFIIDWHNYGYTIMALSHGPAHPIVRLAKWYERFFGPLASHNLCVTNAMKDDLQKNWGIKATTLYDRPASIFRETPLKLQHELFVRLAAVYPQFRHAGSEAERTIFSVRDPADGTVTLRAERPALLLSSTSWTEDEDFSILLTALEEYEGFIRGGASLPPLLCVITGKGPQKEHYMKLIDSLHLEHVEICTPWLEAEDYPLLLGSADLGVCLHKSSSGLDLPMKVVDMFGCCLPVCAVHFNCLDELVKHEENGLIFKDSVELAEQLKTLLSDFPSSDGKLGTFRRNLHSSRGQRWDDNWDQNVLPLITAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B019</accession>
    <name>A0A3P9B019_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545505.1">
        <property type="nucleotide sequence ID" value="XM_004545448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B019"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003209"/>
    <dbReference type="Ensembl" id="ENSMZET00005003338.1">
        <property type="protein sequence ID" value="ENSMZEP00005003209.1"/>
        <property type="gene ID" value="ENSMZEG00005002484.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479585"/>
    <dbReference type="KEGG" id="mze:101479585"/>
    <dbReference type="GeneTree" id="ENSGT00950000182864"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="452" mass="52050" checksum="9B4DAA7A0AA98E47" modified="2019-02-13" version="1">MLSPIQVLCSDITTLSLEPEPFASYTEADIISTVEFNHTGELLATGDKGGRVVIFQREPESKTEPFSQGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAHFLLSTNDKTIKLWKVSERDKRPEGYNLKDEEGRIKDISTVTSLQVPVLKPMDLMVEVTPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWHLDITDRSFNIVDIKPANMEDLTEVITAAEFHPHHCNLFVYSSSKGTLRLCDMREAALCDKHSKLFEEPEDPSARSFFSEIISSVSDVKFSHSGRYLLTRDYLTAKVWDLNMESKPLETYQVHDYLRSKLCSLYENDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCAAGGKRRKDDISVDSLDFTKKILHTAWHPNENIIAIAATNNLYIFQDKLNSEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B089</accession>
    <name>A0A3P9B089_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bardet-Biedl syndrome 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_023008535.1">
        <property type="nucleotide sequence ID" value="XM_023152767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B089"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003350"/>
    <dbReference type="Ensembl" id="ENSMZET00005003482.1">
        <property type="protein sequence ID" value="ENSMZEP00005003350.1"/>
        <property type="gene ID" value="ENSMZEG00005002574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477287"/>
    <dbReference type="CTD" id="55212"/>
    <dbReference type="GeneTree" id="ENSGT00390000012346"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016575">
        <property type="entry name" value="Bardet-Biedl_syndrome_7_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056334">
        <property type="entry name" value="BBS7_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056335">
        <property type="entry name" value="BBS7_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056333">
        <property type="entry name" value="BBS7_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056332">
        <property type="entry name" value="Beta-prop_BBS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074:SF4">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23360">
        <property type="entry name" value="BBS7_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23349">
        <property type="entry name" value="BBS7_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23361">
        <property type="entry name" value="BBS7_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23743">
        <property type="entry name" value="Beta-prop_BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011091">
        <property type="entry name" value="BBS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBS7 beta-propeller" evidence="5">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 GAE" evidence="3">
        <location>
            <begin position="373"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 platform" evidence="4">
        <location>
            <begin position="491"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 helical hairpin" evidence="2">
        <location>
            <begin position="596"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23361"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="712" mass="79476" checksum="B4A950EC696632A5" modified="2019-02-13" version="1">MDLRLNRVDYIQVGVTSQKTMRLLPPLGKKATQKVAIADHDGILTCFGIKKGEAVPVFKTLPGQKIARMDLGGAAGTPQEKIFVCSGSQVRGFTKKGKQFLTFEANLTESINAMHVSGADLFVCASYIYNHYCDCKDQDYYLSGDKINDITCLSTENLTHLVPVLACQDRVLRVLQRSELAYDIEVPGPPSVLELYKEQGEEILFGTTDGKIGLVEIGELSAATKWEIDNDKKKGGILCIDNYDIIGDGVNDILVGRDDGTVEVYGFDSSNEPTLRFEHVLSESVTSIQGGCVGKESYDEVLTATYTGWVTGLTTEPQKAEAGPGDEVRMSKETQSKVEALRAELEQLQVKVLQGREQYQQTSQSSTAVSAVPVFSINDKFTLCQDDASYSLTLEVQTAIDNLLLQSDVPIDLLDVDKNSAVVSFSECDSEQPNGNFLLATYRCQANTTRIELKVRSIEGQYGTLQAYITPRLQPKTCQVRQYQIKPLSLHQRTHSIDQERPMNRLSLVGQFSFAEIHSWVVFCLPEVPEKTPAGESITFYFHNTFLGTQLEATYCKGEGHFKSDNISTISILSDVLSKEATKKKINLNISYEISDDSVSHTLNMIHPKLEYQLLLARKVQLIDALKELQVHEGNADFLIPEYRNILDESANLLEEYKKQPAHLERLYGMITDLFIDKFKFKGQNVKTKVSSLLEILDNYDLNSLLDFFNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B268</accession>
    <name>A0A3P9B268_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiaminase I, tandem duplicate 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B268"/>
    <dbReference type="Ensembl" id="ENSMZET00005003980.1">
        <property type="protein sequence ID" value="ENSMZEP00005003827.1"/>
        <property type="gene ID" value="ENSMZEG00005002956.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234852"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="205" mass="24247" checksum="DE4E74F421419CA7" modified="2019-02-13" version="1">YYLIHPFMGLCYEPVNNIDVYEYLWVSNQDIAEHTLHTPCLQHMQLGDLQADNYVKFIIQDINYLVVVTDMLDEMRNKVEVPEDLHDFMEDRCESYKTYAESTLKEFNLNVRNLHVSIINQPLIRFAVALLPCSRLWLWLANQLNENCCSAYFTWKMSNMCGHPEQHYKALLNKYLTTPEQKELANKLFRQQMDNKHDVCASSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2H8</accession>
    <name>A0A3P9B2H8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Growth arrest and DNA damage inducible beta</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GADD45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561599.1">
        <property type="nucleotide sequence ID" value="XM_004561542.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2H8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003947"/>
    <dbReference type="Ensembl" id="ENSMZET00005004108.1">
        <property type="protein sequence ID" value="ENSMZEP00005003947.1"/>
        <property type="gene ID" value="ENSMZEG00005003049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486438"/>
    <dbReference type="KEGG" id="mze:101486438"/>
    <dbReference type="GeneTree" id="ENSGT00950000182964"/>
    <dbReference type="OrthoDB" id="5976967at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="growth arrest and DNA damage-inducible protein GADD45 alpha"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024824">
        <property type="entry name" value="GADD45"/>
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        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411:SF5">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="160" mass="17946" checksum="7C328152913D89B7" modified="2019-02-13" version="1">MTLEEVVGSNSTEKKMETVSQALEELLVAAQQQDCLTVGVYESAKLMNVDPDSVVLCILATDEEDEDDIALQIHFTLLQAFCCDNDINILRVSGMRRLAQLLKEDTEDSNSNEPRDLHCILVNNPQVQPLQCQALQDVGSFCEESRCSNQWVPCLELQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2I6</accession>
    <name>A0A3P9B2I6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2I6"/>
    <dbReference type="Ensembl" id="ENSMZET00005004296.1">
        <property type="protein sequence ID" value="ENSMZEP00005004125.1"/>
        <property type="gene ID" value="ENSMZEG00005003171.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163991"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF528">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="11">
        <location>
            <begin position="390"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="651" mass="73534" checksum="B7B02AC6D72B0B9E" modified="2019-02-13" version="1">FGHQQTLSLHTRPMSTHLTNLGHGLSNPHHSDHSHMVSILRPSPVLLQSTVFSNAYLSLVFYISLLIVYIFPVYCLLLLFITYYYYLEENCIFFRTIPSDQFQAAALAKLIKHFDWTWIGAVRSDSDYGNNGIASFLEAFHLFNVIFHDVMRQSKKLFYMKILFEELSREPFPPRQWIGSESWVTNPGLRKYSFLAGTIGFGIQKSVIQWLYHHCLLNSPNPYTDTSQLRISNMVYKAVYAIAHAIHNALCQGRNLKKVNFSRNGYDVSFDTNGDPVAIYELVNWQKTMAGITDIVTVGLYDASLPEGQEFQINKNIIWMEGSTKVPVSVCSGRKPICCYDCTACPEGEISNTTGKVKCLSVHVKCFYDANLQHRIHYKNKFFLSFQDILGIILATFSVLGACLTIITTAIFLRHRTSPIVRANNSELSFLLLISLTLCFLCSITFIGAPSEWSCMLRHTAFGITFVLCISCVLGKTIVVLMAFKARLPGSNVMKWFGPPQQRMTVMSFTFIQVLICTIWLVLSPPFPIKNLTAYKEKIILECALGSAVGFWAVLGYIGLLAAFCFVLAVLARKLPDNFNEAKLITFSMLIFCAVWITFIPAYVSSPGKFTVVVEIFAILASSFGLIMCIFAPKCFIILFKPRLMRRHVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2U3</accession>
    <name>A0A3P9B2U3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2U3"/>
    <dbReference type="Ensembl" id="ENSMZET00005004411.1">
        <property type="protein sequence ID" value="ENSMZEP00005004233.1"/>
        <property type="gene ID" value="ENSMZEG00005003276.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234557"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051287">
        <property type="entry name" value="TCR_variable_region"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367:SF18">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="147" mass="16752" checksum="BD7CD22CB67EE48A" modified="2019-02-13" version="1">LMKHCGRIHMSSKSTSTTNQLQEHKVIQEQGDVIAAEGDTVTLGCNFETSASYSYLFWYKQEVNDFPKYVLQRGTTGTADNAQEFPKDRFDAEVDKKEKSVPLKIQKLQLSDSAVYYCALQPTVTGNSKTLYKNLWSKDNRILHNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3P8</accession>
    <name>A0A3P9B3P8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3P8"/>
    <dbReference type="Ensembl" id="ENSMZET00005004718.1">
        <property type="protein sequence ID" value="ENSMZEP00005004516.1"/>
        <property type="gene ID" value="ENSMZEG00005003516.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286933"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF129">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="36"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="234" mass="26770" checksum="ECF3E3469D3EE2D9" modified="2019-02-13" version="1">MAKVRKAERRPPLNKTHKLKRQDWAKKYLKTGFSKVLWTDEMRVSLDGPDGWARGWIGKGQRAPVRLRRQQGGGGVLVWAGIIKDELVGPFRVEDGVKLNSQSYCQFLEDTFFKQWYRKKSASFKKNMIFMQDNAPSHASKYSTAWLARKGIKEEKLMTWPPCSPDLNPIENLWSIIKCEIYKEGKQYTSLNSVWEAVVAAARNVDGEQIKTLTESMDGRLLSVLAKKGGYIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B4E2</accession>
    <name>A0A3P9B4E2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 704</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B4E2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004754"/>
    <dbReference type="Ensembl" id="ENSMZET00005004958.1">
        <property type="protein sequence ID" value="ENSMZEP00005004754.1"/>
        <property type="gene ID" value="ENSMZEG00005003672.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156172"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052253">
        <property type="entry name" value="CR1/CR2-DNA-binding_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006">
        <property type="entry name" value="PAPILLOMAVIRUS REGULATORY FACTOR PRF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006:SF7">
        <property type="entry name" value="ZINC FINGER PROTEIN 704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="409" mass="44474" checksum="33E878BC073815E9" modified="2019-02-13" version="1">HICIFRVKDLDLFVKKRVIRSFSLTDWKQLSKVFFCFCFHRRSEEEVDMDKVTAAMVLTSLSTSPLVRSPPVRVSEGLSGSWKDNGSAGPFTPSSNSSSGGYWSWSAPSDQSNPSTPSPPLSADSFKPFRVPSLGGVGPGPAGPEDPILDEQDGSSLLFDEPIPRKRKNSMKVMFKCLWKNCGKVLSTAAGIQRHIRTIHLGRNCDSDLSDGEEDFYYTEIKLNTDSVADGLSSLSPASPSVLSPPPPPPSPLPSVSQLPDSHKPTQPSDTKEPHAGGTTPLSRSAPSALYLIHTDHAYQVMKTYVNNNSAGSASTSFTPTNSSSFSISWQSPPVTFTGTTVSPSKSQGFGDQRSQTIAVLSSPPRATAALSRKVRGEGKKCRKVYGMENRDMWCTACRWKKACQRFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5A0</accession>
    <name>A0A3P9B5A0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily domain containing 13a-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004558356.1">
        <property type="nucleotide sequence ID" value="XM_004558299.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5A0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005073"/>
    <dbReference type="Ensembl" id="ENSMZET00005005297.1">
        <property type="protein sequence ID" value="ENSMZEP00005005073.1"/>
        <property type="gene ID" value="ENSMZEG00005003924.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482249"/>
    <dbReference type="KEGG" id="mze:101482249"/>
    <dbReference type="CTD" id="100142644"/>
    <dbReference type="GeneTree" id="ENSGT00940000164377"/>
    <dbReference type="OrthoDB" id="62987at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000380">
        <property type="entry name" value="Transmembrane protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040035">
        <property type="entry name" value="TMEM180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN CONTAINING 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28658">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="478" mass="53881" checksum="5A49CAD2DD705676" modified="2019-02-13" version="1">MNVFRHLINFGVNPAALAYAMTTLGSSMINNMFSFYYVKLFLNRYKISEGAFHQSQVVYMVWNAVNDPLFGYLQDNSRVPCCSQRRLSILYGAPLYSLAFLLAWFPWRSYAPGDWLSGLHLTVALCAFDGMLTFVLLAQCALFAEISSHHQNRLRLIKYNQVASLIGSSSVLFCGVVSNNMEDFLAFQAFAVLIAILSCGCMLYTGFHSESRFDNKASQSDAPASVDQTSHPLACSFSTLKTLTWQILTNRDFQLFVLMNFFQVFMLAFFNNFTMIFTEHLIPPDVLPSLAKSIMYGAAFICPQLLVLSSQSLLHRHGYYRIILFIFYVEAGMAAVMLAIGPQHYYFMAFFLTINMVIIQASFSLFGLPLADIIDTDLQKYKRSSPLSSMVFGTNALFTKPAQSLAPMIVLNILNHFGYEQLKDVTKDSDPSALESLHRAMFYLVCLVPMCVAALQVLAWRPFSIRNSHTVDTKYIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B606</accession>
    <name>A0A3P9B606_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RAB22A, member RAS oncogene family</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547669.1">
        <property type="nucleotide sequence ID" value="XM_004547612.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B606"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005323"/>
    <dbReference type="Ensembl" id="ENSMZET00005005552.1">
        <property type="protein sequence ID" value="ENSMZEP00005005323.1"/>
        <property type="gene ID" value="ENSMZEG00005004122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477923"/>
    <dbReference type="KEGG" id="mze:101477923"/>
    <dbReference type="CTD" id="57403"/>
    <dbReference type="GeneTree" id="ENSGT00940000157009"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000346">
        <property type="entry name" value="RAB31, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="194" mass="21604" checksum="8BD80F1A1A096038" modified="2019-02-13" version="1">MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEDSFQTLKNWVKELRQHGPPNIVVAIAGNKCDLSDAREVPEKDAKDYADSIHAIFVETSAKNAININEVFVEISKRIPVVDEAGGSSARGFKLGRQASESRRTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B7B5</accession>
    <name>A0A3P9B7B5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat domain 39A</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014267159.1">
        <property type="nucleotide sequence ID" value="XM_014411673.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B7B5"/>
    <dbReference type="Ensembl" id="ENSMZET00005006018.1">
        <property type="protein sequence ID" value="ENSMZEP00005005766.1"/>
        <property type="gene ID" value="ENSMZEG00005004463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474980"/>
    <dbReference type="KEGG" id="mze:101474980"/>
    <dbReference type="CTD" id="22996"/>
    <dbReference type="GeneTree" id="ENSGT00950000182917"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF3">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="618" mass="70650" checksum="D986414CAFC9D863" modified="2019-02-13" version="1">MSFMNSWKRSVKKHDSKRDAMNPQDVPDSPDSPSRLSDVNSPELDSIITDFKLQIPDDKDGLESTDPSNGCSRSDLTLALEDCMAALDLFLRNDFEEAQARLRCRNKDSMYHALTYATILEMQAMMTFDPQHILVAGNTMKEAQAICQRQRKKSSFSKNFTEEELHAEVCYAECLLQRAALTFLQDENMISFIKGGIKVRNSYQTYKELHTVLQSSGYTHGDNHGHFEGGVKLGVGAFNLMISMLPTRTLKLLEFVGFSGNKEFGLQQLQEGSVESTFRSFLCNMLLLCYHTFMSFILGTGEGDVEDAEKLLEPYLKKYPKGSIFLFFAGRIEEIKGNLDAAIKRFEECCEAQQQWKQFHHMCYWELMWCFTYKRHWKMAYFYADLLSKENSWSKATYAYMKAAYLSMLTKDDCLTFGETALSLFRQVPGLKQKIAGKSLPTEKFAIRKARRYLAENPVPLPAPPLEMMYIWNGYTVIGKHKDLTEGMLKTLDEAQAQLESLPRTEFSIDDQCLLSLLKGLCLKHLGHHEEAEHYFTLVLCNETQIKYDHYLVPNALLEHGLLCLQQGRKDDAIKLLETAKQNYKNYSMESRTHFRIQAALHKAKGSGENGIHVPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B7E4</accession>
    <name>A0A3P9B7E4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B7E4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005834"/>
    <dbReference type="Ensembl" id="ENSMZET00005006088.1">
        <property type="protein sequence ID" value="ENSMZEP00005005834.1"/>
        <property type="gene ID" value="ENSMZEG00005004511.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286933"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF129">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="140"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="338" mass="38538" checksum="6F1C9ED7F953C559" modified="2019-02-13" version="1">MGQKKDLTGSEKSKIVRYLAEGCSSLKIAKLLKRDHRTIKRFIQNSQQGRKKRVEKPRRKITAHELRKVKRAAAKMPLATSLAIFQSCNITGVPKSTRCAILRDMAKVRKAERRPPLNKTHKLKRQDWAKKYLKTGFSKVLWTDEMRVSLDGPDGWARGWIGKGQRAPVLLRRQQGGGGVLVWAGIIKDELVGPFRVEDGVKLNSQSYCQFLEDTFFKQWYRKKSASFKKNMIFMQDNAPSHASKYSTAWLARKGIKEEKLMTWPPCSPDLNPIENLWSIIKCEIYKEGKQYISLNSVWEAVVAAARNVDGEQIKTLTESMDGRLLSVLAKKGGYIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B7L1</accession>
    <name>A0A3P9B7L1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SYCE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B7L1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005889"/>
    <dbReference type="Ensembl" id="ENSMZET00005006145.1">
        <property type="protein sequence ID" value="ENSMZEP00005005889.1"/>
        <property type="gene ID" value="ENSMZEG00005004552.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000172951"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026676">
        <property type="entry name" value="SYCE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21731">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21731:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15233">
        <property type="entry name" value="SYCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="154" mass="18541" checksum="E07064E02504E390" modified="2019-02-13" version="1">QYKLKSSNWRQSTKKRKVCKCIKCEPTDEHSCSSFYCILCLYLCVCFRHLQLNKKSEELLEQYRYEIQDVKLKHRKLRMRFENQLHQLIDQHKNLHYVFTPERLPDELKSVENTKSQLLAAEKLKLTQLHNLDEELEKMKNQKQAQEAAAETQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8L8</accession>
    <name>A0A3P9B8L8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SplA/ryanodine receptor domain and SOCS box containing 4a</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562867.1">
        <property type="nucleotide sequence ID" value="XM_004562810.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004562870.1">
        <property type="nucleotide sequence ID" value="XM_004562813.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012777776.1">
        <property type="nucleotide sequence ID" value="XM_012922322.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023009004.1">
        <property type="nucleotide sequence ID" value="XM_023153236.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024660583.1">
        <property type="nucleotide sequence ID" value="XM_024804815.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024660584.1">
        <property type="nucleotide sequence ID" value="XM_024804816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8L8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006221"/>
    <dbReference type="Ensembl" id="ENSMZET00005006510.1">
        <property type="protein sequence ID" value="ENSMZEP00005006221.1"/>
        <property type="gene ID" value="ENSMZEG00005004837.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005006514.1">
        <property type="protein sequence ID" value="ENSMZEP00005006225.1"/>
        <property type="gene ID" value="ENSMZEG00005004837.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005006519.1">
        <property type="protein sequence ID" value="ENSMZEP00005006230.1"/>
        <property type="gene ID" value="ENSMZEG00005004837.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469014"/>
    <dbReference type="KEGG" id="mze:101469014"/>
    <dbReference type="GeneTree" id="ENSGT01030000234629"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF3">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="35"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="278" mass="31397" checksum="FD3984C97004BAD7" modified="2019-02-13" version="1">MGQKISGTIKSVDVRGEPSYRPVRRELRGPDFCRPPRLDLLLDMPPASPETQLQHAWNPDDRSLNVFVKEDDKLTFHRHPVAQSTDCIRGKVGYTRGLHVWRIHWPARQRGTHAVVGVASAEAPLHSVGYTALVGSDSESWGWDLGRNRLYHDGKNRPVSTSAPTYPSFLEPDESFVLPDCLTVILDMDEGTLSFMVDGQYLGVAFRGLKGKRLYPIVSAVWGHCEVSIRYVNGLDPEPLPLMDLCRRVARLALGRERIHHIDTLPLPQTLKNYLQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBT1</accession>
    <name>A0A3P9BBT1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004563222.1">
        <property type="nucleotide sequence ID" value="XM_004563165.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBT1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007350"/>
    <dbReference type="Ensembl" id="ENSMZET00005007660.1">
        <property type="protein sequence ID" value="ENSMZEP00005007350.1"/>
        <property type="gene ID" value="ENSMZEG00005005639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464073"/>
    <dbReference type="KEGG" id="mze:101464073"/>
    <dbReference type="CTD" id="84447"/>
    <dbReference type="GeneTree" id="ENSGT00940000157743"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902236">
        <property type="term" value="P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000088">
        <property type="entry name" value="E3 ubiquitin-protein ligase synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="291"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="397"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="533"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="634" mass="69254" checksum="86F25CA0E5794532" modified="2019-02-13" version="1">MVRAALVTVTSLALTGAVVAHAYLLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKFMRKVFFGQLRAAEMEHLIERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWVFHMRVLSLMGLLGVMDFLFVNHACHSIITRGASVQLVFGFEYAILLTMVLTTFIKYLLHTIDLQSENPWDNKAVYMLYTDLFTGVVKVFLYIAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAVMSRRAIRNMNTLYPDATPEDLQASDNVCIICREEMVTGAKKLPCNHIFHSSCLRSWFQRQQTCPTCRMDVLRATNNNQTPAPAQAPPPAPAAPANAPANAPAGQPPNVALGMLPGFPPGIFPFWGPFPAVPPPAGAAVPPAPGATDAPQSSTESTQTASTTQPTTSTADSAATAAGPGSAVPGFPFSFPPPPFPAAPWLPMPPPPPFVSSMPPPPPSLSRLSEEELRELEAEGRRGLEARLQCLQNIHTLLDAAMLNIHHYLSTVATLTPPRAGSTGEASGTNRTASSSTAGSNTESPSTDRDSSLSDQVNGATLSSQSADSTERKEKMDEGVEDGEDGEPNAAELRRRRLRKLETTPSSSSSPPSPPPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BC87</accession>
    <name>A0A3P9BC87_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CNPPD1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNPPD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552720.1">
        <property type="nucleotide sequence ID" value="XM_004552663.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BC87"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007515"/>
    <dbReference type="Ensembl" id="ENSMZET00005007831.1">
        <property type="protein sequence ID" value="ENSMZEP00005007515.1"/>
        <property type="gene ID" value="ENSMZEG00005005755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480104"/>
    <dbReference type="KEGG" id="mze:101480104"/>
    <dbReference type="CTD" id="27013"/>
    <dbReference type="GeneTree" id="ENSGT00390000000862"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="440" mass="48987" checksum="6E01BFF03CA33EF1" modified="2019-02-13" version="1">MDFDALFNENTFQFSDFQEFTFLPGHQKLTERVRKRLYYGLDNDVSLDALSCPVTDIAVEIFQKSAPSPIRKLQKKYAAHVAREACISPCAMMLALVYIERLRHRNPEYLQKISSSDLFLISMMVASKYLYDEGEEEEVFNDEWGAAGKLDVKTVNNLEMNFLNAIEWSLFADPNDFFDLLSQLETSIAERQGMKRGWFSYTDLCVLLEHSVWSQALTAIYQHFTKVSCMLGLVYLTSVAGLIATSAVIHQLSLSRGGQSLLPPDEISLTHFLASNLSPETSSSARRLPCCVLANKSVNRQTGSPGSRQHHSQRPPLSSTQTSVLCLWGSLLASMGHIHPETKPDVEASQTWSPVSFICPGCLATLPPLACGLRNTSSVLPHSPFENHQPHLSWFSSSLLGATKPSVDSHLDIFPPVQLRPCHPKSMLPVDKVQALLMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCK6</accession>
    <name>A0A3P9BCK6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer. Interacts with per1 and per2. Component of the circadian core oscillator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 15">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004563122.1">
        <property type="nucleotide sequence ID" value="XM_004563065.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCK6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007635"/>
    <dbReference type="Ensembl" id="ENSMZET00005007952.1">
        <property type="protein sequence ID" value="ENSMZEP00005007635.1"/>
        <property type="gene ID" value="ENSMZEG00005005827.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005007958.1">
        <property type="protein sequence ID" value="ENSMZEP00005007640.1"/>
        <property type="gene ID" value="ENSMZEG00005005827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485667"/>
    <dbReference type="KEGG" id="mze:101485667"/>
    <dbReference type="GeneTree" id="ENSGT00940000153536"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000194">
        <property type="entry name" value="Casein kinase I isoform delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="9"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="300"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="417" mass="47365" checksum="8A6D4C50AE2B4519" modified="2019-02-13" version="1">MELRVGNKYRLGRKIGSGSFGDIYLGANIATGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRTAEDGDRERRTADERDERIGGVPRGSASRGLPPGPNPGAPNRVRNGPEQAISNPASRVQQSGNTSPRAISRAERERKVSMRLHRGAPANVSSSDLTARHDQSRISTSQVSVPFEHMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDE5</accession>
    <name>A0A3P9BDE5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 59-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM59 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014269730.1">
        <property type="nucleotide sequence ID" value="XM_014414244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDE5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007893"/>
    <dbReference type="Ensembl" id="ENSMZET00005008212.1">
        <property type="protein sequence ID" value="ENSMZEP00005007893.1"/>
        <property type="gene ID" value="ENSMZEG00005006015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473331"/>
    <dbReference type="KEGG" id="mze:101473331"/>
    <dbReference type="CTD" id="25789"/>
    <dbReference type="GeneTree" id="ENSGT00390000008279"/>
    <dbReference type="OrthoDB" id="6371519at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022065">
        <property type="entry name" value="Uncharacterised_TMEM59"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28652:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 59-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28652">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 59-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12280">
        <property type="entry name" value="BSMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018249742" evidence="11">
        <location>
            <begin position="26"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="338" mass="37025" checksum="7A92AEE67A4AE91D" modified="2019-02-13" version="1">MLRLGGRMCALSALLSVLLAGLAAASSDLFDDQLGDINYCKKQCALTIRNKSPAKDSIMNACHRGCRLYSICQFVNGNAGFNTSREECQGACQEAYIKLLEQEACSTGCASQPSEPEIKRRKLKAMTLRPKPPSVMEAVSSWCNDIVSSAQSFISSTWTFYLQADDGKVVVFQSQPEMEYSLPELQAPRSSVADKPWPQVHSHTQRPHGARGHGEKGTPKAAAKGKHAVQHPEDLASEHDFLGCMSRRSGLPRWILAACLFLSIMVMLWLSCASLVTAPEQHIKTQLSINGDKEFLENAHKVNPYHLSPVIAVTVKQSEESQEAGPLPVKVDLNKTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEQ8</accession>
    <name>A0A3P9BEQ8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Integrin subunit alpha 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEQ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008385"/>
    <dbReference type="Ensembl" id="ENSMZET00005008718.1">
        <property type="protein sequence ID" value="ENSMZEP00005008385.1"/>
        <property type="gene ID" value="ENSMZEG00005006353.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159891"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF90">
        <property type="entry name" value="INTEGRIN ALPHA-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
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        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Integrin alpha N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017851997" evidence="13">
        <location>
            <begin position="21"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="936"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="246"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="368"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="14">
        <location>
            <begin position="412"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="15">
        <location>
            <begin position="578"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="745"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="16">
        <location>
            <begin position="858"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008385.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113812" checksum="6F39733BB5CFCA3A" modified="2019-02-13" version="1">CSLFFALSSVILVGAPRAAGQGKLTGSRPGALFRCPITPEEYDCERVDIDGDESKHNQWLGVTVKSQGIGGKVVTCAHLYELRQRVNQSSETRDPIGRCYVLSEDLTNRDDLDGGEWKFCEGRPQGHEQFGFCQQGLSVSFTPDKNFILFGAPGTYNWKGNMRVQLLNQTLLDLGIYDDGPYEVADEKQLNAQLIPVPYHSYLGFSVDSAMGIMSLGELTFVAGAPRANHTGAVVLLKKDNVYRLVPQHIFWGEELASSFGYSVATTDLNSDGWTDLIVGAPNFFDRKAEIGGAVYVYLNPFGHWDDQARPIRLNGTYDSMFGMTVSNVGDLDQDGYGDIAVGAPFDGDGKVFIYRGSKSGIETKPAQVLDGRDFDVRRFGYSISGGLDIDNNHYPDVAVGSLNDSVVLFRSRPVIHVKRDITIDPPQIDLEQSNLLFRCVCPDISVFQPICLPLCAPPFYSIQALVVRFEADTERRKVGLPHRVTFLGRSLLEPEYTQTEEVQLNRQRHAVCTNAVFQLHENIRDKLRPISLVITHTIKPVPPRRHSAKRLEKLPPILNVSPSNTLHSEVNFLREGCGNDKICQSNLKLSYQFGTRPLNSDLFIPLPKDEDDVQVFSLSDQRLVVLDITVTNMPSDPLYPEEDGDDAHAAQLIISLPNTLSYAGSRIPEQMRCQANQNGSQVECDLGNPVKRNSKLKFSISLSTANITIETTELTAELSLKTISEQPDLVPVTAYAKVVIELPLSVSGRVNPDKLFFSGAVRGESAMSSLDDIGSAVDFEFVVANPGQALQTLGSAFLNIMWPYELANEKWLLYPASLTFQGHPETQCSPTSSLKLVRRTRSREPGKRPERGLLISSRCVLFQCPLHSFSGQAVLKIHARLWNSSFIEDFPAVSALELLVRANITVKSSIKHLVLKDAAVSVMIYPEHGVTDQYWIPWWIILIAILAGVLLLALLVLMLWKCGFFRRAHYKDKLPQYHAVKIPREDRPQFQTEKSGGVQKKEWATHWTDCHPLGTLMSQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFN9</accession>
    <name>A0A3P9BFN9_9CICH</name>
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        <recommendedName>
            <fullName evidence="2">Pentraxin (PTX) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BFN9"/>
    <dbReference type="Ensembl" id="ENSMZET00005009048.1">
        <property type="protein sequence ID" value="ENSMZEP00005008707.1"/>
        <property type="gene ID" value="ENSMZEG00005006625.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234935"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018260754" description="Pentraxin (PTX) domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="2">
        <location>
            <begin position="51"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="257" mass="28990" checksum="B6C5463B2D85FFBC" modified="2019-02-13" version="1">MNSIKSLSSLAICFCIFMSACPLGSSKRKKIFKILYIKLVFQVQPCLWQLHSGVPVPALRELSVCMSLRRTISADWTGFEYKAPGNRETELGLGGKNGKLFVKLFGHEWQYENNLTVNGWHSVCLTWSGQAQRLRISINSTFLIEICLTTSQQLSKNGTLTLGVSHYVNANGEIQPETGTNLVGEIALFRMWAREWSLEELKNLNCTDGDLVSWDLKQWTYSCPPEPSINLHCGKYIMGFYFCISQSSSLDYAQFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHK3</accession>
    <name>A0A3P9BHK3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eukaryotic translation elongation factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EEF2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BHK3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009394"/>
    <dbReference type="Ensembl" id="ENSMZET00005009748.1">
        <property type="protein sequence ID" value="ENSMZEP00005009394.1"/>
        <property type="gene ID" value="ENSMZEG00005007103.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154662"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
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    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
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        <property type="entry name" value="Translation elongation factor 2"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
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    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
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        <property type="entry name" value="G_TR_CS"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF29">
        <property type="entry name" value="ELONGATION FACTOR 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="17"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="858" mass="95295" checksum="4D4D0F8CEAFC043E" modified="2019-02-13" version="1">MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVSKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLYYELSENDTAFIKQSKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIGERIKPVLMMNKMDRALLELQLEPEDLYQTFQRIVETVNVIISTYGEDENGPMGNIMVDPVLGTVGFGSGLHGWAFTLKQFAEMYAAKFAAKGNAQMTPVERCKKVEDMMKKLWGDRYYDTANGKFVKSAIGADGKKYPRTFCALVLDPIFKVFDAIMNFRKDEAAKLIQKMDIKLDNEDKDKEGKPLLKAVMRRWLPAGEALLQMITIHLPSPVTAQKYRCELLYEGPGDDEAAMGIKNCDSKAPLMMYISKMVPTSDKGRFYAFGRVFSGSVSTGLKVRIMGPNFVPGKKDDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTYDQAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLSKSDPMVQCIIEESGEHIVAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSAESDIMCLSKSPNKHNRLFMKARPFEEGLAEDIEKGDVTSRQELKGRARYLADKYEWDVGEARKIWCFGPDGTGPNLLVDVTKGVQYLNEIKDSVVAGFQWAAKEGVLCEENMRAIRFDIHDVTLHTDAIHRGGGQIIPTARRALYACELTAEPRIMEPVYLVEIQCPEGAMGGIYGVLTRRRGHVFEESRVMGTPMYVIKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGNPLDATSKPGVVVLETRKRKGLKEGVPALDNYLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ95</accession>
    <name>A0A3P9BJ95_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ95"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010014"/>
    <dbReference type="Ensembl" id="ENSMZET00005010380.1">
        <property type="protein sequence ID" value="ENSMZEP00005010014.1"/>
        <property type="gene ID" value="ENSMZEG00005006023.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167030"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF744">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR WITH WD REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="273" mass="31223" checksum="72915E6E5BCA5678" modified="2019-02-13" version="1">MKLKRFLLRYYPPGIILEYEKGGFLRTKSIDLLDLTPECVSYELVEEIRQSEPLVTKAQADQVKQLVIRLQKKQTQQDHHRFCFSKELKAHILPLTNVAFDKSGSSYDRTCRVWDTASGQSCTLLEGHRTENLYNMGGLRLALFDKTCKLWCAETGKFFHTYRGHMEKYTLVATSSMDTTAKLWDVKIISCISHTVVVGKYLHFMMHFFIHPLHVSDNAISFQGHTAEVLSLCFNTVGSQLVTGSFDHTVTIWDTGHTLIGHMGEISNTHQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BK66</accession>
    <name>A0A3P9BK66_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase/reductase (SDR family) member 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BK66"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010041"/>
    <dbReference type="Ensembl" id="ENSMZET00005010407.1">
        <property type="protein sequence ID" value="ENSMZEP00005010041.1"/>
        <property type="gene ID" value="ENSMZEG00005007563.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155226"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="CDD" id="cd05332">
        <property type="entry name" value="11beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="335" mass="37128" checksum="D0580CB6D73404C6" modified="2019-02-13" version="1">MESCTVSALSCFIAFCLLVCLIGFIFADADFTLLWASLTGQRPERKLKGLVVWITGASSGIGEELAYQLAKCGSRLILSARREDELHRVKRHCLETSELKDEDILVLPLDLLERRSHETKTKTVIGYFGHIDILINNGGRSQRSLFLETSVDVCQALMELNFFGTVSLTKQVLPHMTQRGRGSIVTVSSLFGLTAAPLATGASASKHALQGFFNSLRTELTDYPKILISTVCPGPVQSQIAKNAFTAEINKPPPTVGHLKRMPTDRCVRLMVVGISNGVKEMWISQQPMLLLYYTWQYAPTFAWSVSDRLGRKWVQNFKAGRDADSANLTKPKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BL03</accession>
    <name>A0A3P9BL03_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibroblast growth factor</fullName>
            <shortName evidence="2">FGF</shortName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573668.1">
        <property type="nucleotide sequence ID" value="XM_004573611.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BL03"/>
    <dbReference type="Ensembl" id="ENSMZET00005010992.1">
        <property type="protein sequence ID" value="ENSMZEP00005010619.1"/>
        <property type="gene ID" value="ENSMZEG00005007986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482517"/>
    <dbReference type="KEGG" id="mze:101482517"/>
    <dbReference type="GeneTree" id="ENSGT00940000156984"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23309">
        <property type="entry name" value="beta-trefoil_FGF11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000001">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="413" mass="45234" checksum="05A5BA2ACDCD8E11" modified="2019-02-13" version="1">MQWFFVQKPTAAAYRRLHASAAACLSVAAAPLPAPRGRRRHLKRSARGLSTPRRPGSSSDRSLAEDRRQLGQPEAGTEETSAAAVALFLPHGDDVDAEYVRLVVSELVGEPGEKAGEEPGFLLLFLSMVQVRAAKHRRTEPNSWPALLACKQGGVSAPMRWVNFRLPHPERLSSPTSSSSTPSSSSSSPPVSAKSMRFIWNNIFSKGSHMLQCLCGRSLKKNKNPTEPQLKGIVTRLFCRQGFYLQMGQDGSLDGTKDDSTNSSLFNLIPVGLRVVAIQSVKTGLYIAMNGEGHLYSSELFTAECKFKESVFENYYVIYSSMLYRQKESGRAWFLGLNKEGQVMKGNRVKKTKPAAHFLPKPIEVAMYREPSLHDVGEAVPKLVGCPPSKSTTTGPVVMNGGKPVNKPDKEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLA7</accession>
    <name>A0A3P9BLA7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="20">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="20"/>
    <dbReference type="RefSeq" id="XP_004541192.1">
        <property type="nucleotide sequence ID" value="XM_004541135.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLA7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010707"/>
    <dbReference type="Ensembl" id="ENSMZET00005011084.1">
        <property type="protein sequence ID" value="ENSMZEP00005010707.1"/>
        <property type="gene ID" value="ENSMZEG00005008029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468250"/>
    <dbReference type="KEGG" id="mze:101468250"/>
    <dbReference type="CTD" id="3702"/>
    <dbReference type="GeneTree" id="ENSGT00940000158850"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01238">
        <property type="entry name" value="PH_Btk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09934">
        <property type="entry name" value="SH2_Tec_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00402">
        <property type="entry name" value="TECBTKDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00107">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="7 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 17" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 20" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="23">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="21">
        <location>
            <begin position="237"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="363"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="617" mass="71317" checksum="267B2DC07FFCC808" modified="2019-02-13" version="1">MFPRVILKGTLIKKSQQKKRVSPCNYKERFFVLDTQDLKYSERRPGKKPLLKGCIELSRIKCVEIVCTDVPIPCSFKYPFQVFHESYYLYIFAPDNDCRQKWVRALKEETKNNNLVPKYHPNFWMDGKWRCCQQTEKLATGCNVYDPVGYASKKPLPSLPEPEMELEDSGQQKVIALQNYTPQGDNDLPLQKDQEYLLVKNSHSTWWLVQDERGNSGFVPSTYVAEKSINNFERFEWYNKNISRAQAEELLMKEGKEGAFIVRDSRQAGVYTVSVFTKAPGSNGEKNPRVKHYQIRQTETSPASFYLAEKYLFSTIPELIYYHQHNAAGLITRLRHPVSQGRCCSQDSTDITKDQWEVDPEELILGQEIGSGQFGLVLEGSWRDLKVAVKMVREECMSDDEFKEEARIMMRLSHSKLVQLYGVCTQHSPICLVFEYMENGCLTDYLRERKGSLSQDILLGMCLDVSEGMAYLEMSNFIHRDLAARNCLVSKNNEVKVSDFGMTRFVLDDQYTSSQCSKFPVKWSAPEVIRYCKFSTKSDVWSFGVLMWEVYNEGRLPYENRTNAEVVDSLNAGLRLLKPRLAPDSVHLLMEWCWKEKPDDRPTFGLLFHELASLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BMS5</accession>
    <name>A0A3P9BMS5_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
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        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
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        <property type="nucleotide sequence ID" value="XM_014410233.3"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005011238"/>
    <dbReference type="Ensembl" id="ENSMZET00005011627.1">
        <property type="protein sequence ID" value="ENSMZEP00005011238.1"/>
        <property type="gene ID" value="ENSMZEG00005008446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472976"/>
    <dbReference type="KEGG" id="mze:101472976"/>
    <dbReference type="CTD" id="4287"/>
    <dbReference type="GeneTree" id="ENSGT00390000001830"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042461">
        <property type="term" value="P:photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.40:FF:000005">
        <property type="entry name" value="Ataxin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000005">
        <property type="entry name" value="ataxin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATAXIN-3-RELATED"/>
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    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="261"/>
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        </location>
    </feature>
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        <location>
            <begin position="318"/>
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        </location>
    </feature>
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        <location>
            <position position="14"/>
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        </location>
    </feature>
    <feature type="active site" evidence="13">
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    <feature type="active site" description="Proton acceptor" evidence="12">
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        </location>
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        </location>
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        <source>
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    <sequence length="348" mass="39058" checksum="5A4967B893282F47" modified="2019-02-13" version="1">MDSIFHEKQEGSLCAQHCLNNLLQGEYFTPVDLSSIAHQLDEEERMRMAEGGMASEEYRTFLQQPSGNMDDSGFFSIQVISNALRVWGLELILFNSREYQSLMINPINEKAFICNYKEHWFTIRKLGQQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVIRGNLPECEAEQILGIMRVQQQQRPRLIGEEEAQTSSGSRSVALGQSEMAFGVEDEVVDEDEELKRALALSRQDIDVEDEEADLRRAIQLSMQGAVMSNKSSECGVGNVKSGSQAAGSAAREQREGQNETLTAEELRKRRQAYFDRQQQQTQTNIPQPKDTQPTGSSGSVNAGSEGDQQPKPSQ</sequence>
</entry>
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            <taxon>Neoteleostei</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
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                <person name="Aken B."/>
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                <person name="Amemiya C."/>
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                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
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                <person name="D'Cotta H."/>
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                <person name="Gaffney L."/>
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                <person name="Ron M."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
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                <person name="Streelman J.T."/>
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            <dbReference type="PubMed" id="25186727"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <sequence length="457" mass="50526" checksum="C4AEE0E3A54FC4EE" modified="2019-02-13" version="1">MGDIRQSLLPRDVLSAAKELLYHLDIYICNLVQSGRQPPQVDSKTLELVEEFILHAPKDRNTTARRMSALQELQLLEIMCSCFQEQSRDAVRQLMFAALFNLQGNQADESRMALLGKLVSMAIAVGRVPILECAATWLQRTHRVYCVRLAQVLVDDYCSMVPGSVPTLQNIHSASPRFCCQFITAVTTLYDFTSEELTPPLELLQMIVSWIQDDPHLVLITFLNSPISGSQPITSLDVTPLGGLVRWCIKAPLVYSRDKKQALTNGSSENEPEVGPLFSALHLSVLQVLMLLPNILNEKGLFGRLALLQMESLAALTSDLSRLLDQADKHTHTSSADTLALSQLALDRLAQALQVAMASGALLCSREDLRAICSRLPHNNLLQLVLFGPVMYYNNIHTSPLAYSPHAAHSPIAPLPALPTHRAHTPHAPLAPHPSSHPQYPAQPFMTGMPFPFRPSH</sequence>
</entry>
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    <accession>A0A3P9BP74</accession>
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            <taxon>Pseudocrenilabrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Berlin A."/>
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                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
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                <person name="Gnerre S."/>
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                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
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                <person name="Harris R.M."/>
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                <person name="Rakotomanga M."/>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
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        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000265160">
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF17">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="325" mass="35870" checksum="E5C5D1028712B27F" modified="2019-02-13" version="1">MAESAACPAFQLGRPRYDQGSFFGRLRHFVDIIDPSTLFVSEKRLNECIKLLDDYKHGSLPPGVSDVQLWEAQKIKQAIIHPDTGEKIFMPFRMSGYVPFGTPIVIGLLLPNQTVVSTIIWQWLNQSHNACVNYANRNATKPTPTSKFIQGYAGAVTSAVSIAVGLNVLIQKANKLSPATRMIIQRLVPFPAVASANICNVGLMRHNELSEGIDVLDNNGNIVGSSRIAARHAIMETAFTRVVLPMPIFVLPPIIMSYLERLRFLQSNRRLLLPIHSVVCLVTFGLSLPVAISLFPQMSQIEVSCLEPEIAMATDCKVVTYNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTA2</accession>
    <name>A0A3P9BTA2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Gap junction protein delta 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="STRING" id="106582.ENSMZEP00005013162"/>
    <dbReference type="Ensembl" id="ENSMZET00005013612.1">
        <property type="protein sequence ID" value="ENSMZEP00005013162.1"/>
        <property type="gene ID" value="ENSMZEG00005009888.1"/>
    </dbReference>
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        <property type="component" value="LG8"/>
    </dbReference>
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        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086077">
        <property type="term" value="F:gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
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        <property type="entry name" value="Connexin_N_sf"/>
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    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF5">
        <property type="entry name" value="GAP JUNCTION DELTA-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
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        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0303">Gap junction</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="11">
        <location>
            <begin position="137"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="215" mass="25342" checksum="19162A950D8DA35D" modified="2019-02-13" version="1">MGEWGFIGGFFDALQTHSPMLGRFWLVLVLVFRIVILETVASDMFEDEQEEFTCNTLQPGCKQVCYDLAFPISQYRFWVFHIVLIATPPLLYLIYATHQHYKRANRSSSRKKTSRENREEKTLRALYIITLIFRIMAEIGFLFVQWRLYGFKVEAHFPCSRSPCPLTVECFTSRPAEKTIFLLFYFAVGVVSRTLNHTCCYHCILSFYYKFVTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTW8</accession>
    <name>A0A3P9BTW8_9CICH</name>
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        <submittedName>
            <fullName evidence="7">Ral guanine nucleotide dissociation stimulator-like 3a</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004538953.2">
        <property type="nucleotide sequence ID" value="XM_004538896.2"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005013339"/>
    <dbReference type="Ensembl" id="ENSMZET00005013791.1">
        <property type="protein sequence ID" value="ENSMZEP00005013339.1"/>
        <property type="gene ID" value="ENSMZEG00005010025.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101481095"/>
    <dbReference type="CTD" id="100149956"/>
    <dbReference type="GeneTree" id="ENSGT00940000165438"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00153">
        <property type="entry name" value="RA_RalGDS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF220">
        <property type="entry name" value="RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="107"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="264"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="694"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="641"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="804" mass="90064" checksum="59F5B0EE7F40E993" modified="2019-02-13" version="1">MRTILPVCGGSDAGEPRSLRSRVGRMKRLLWLRQSQCMGVHMNTEPGVWLRSFQFLDTDGQCEDPVQEWGEEEEDGAVFGITLRREPVPTSTMGELPMSFVQYHTVKVRRLKAATLERLVTHLLDPEKRESDFIQVFLSTYRAFTSTSTLIELLFQRNDSVTNLDNSVNANSTLVPVIRLWLEEYSEDFNEPPQYQALRTLCVHMQHRLCFRCLVHHAEGLLKRFQEQDCGQPASEHSSESLQQVDEAEMSTKNEDKYNFMDLPVREVAEQLTRLDADLFVKVEPFHCLGCVWSQRDKKENRNLAPTVRATISQFNAVTNSVITSLLCTSPHLPSTSSPGLSPSLSSNFLYPSSAPSSPCILRTSPCHRARVIERWIAVAQECRELKNFSSLRAILSALQSNAVYRLKKTWAAVSRESMATFDHLCETFPDENCVLTNREILVEDGTHPHSSGMSADKSPRLCSESRQMNYSSGVVPYLGTYLTVLTMLDTALNDTVDGGLINFEKRRREFEILSQIRQLQASCSHYRFPVNPRIAAWLQTHTLLTDQESYELSRGLEPPADLCPSSPNTWSSYLLTRKLTALRTSVDTPVRKTHADQISVSSSGSSGSDMEDLSVPQLSPLRLKLKSFSGSLHNVTEGTSSGSSSPSLSRSSCSSSHPDLTSPSLVLNPDPSSSSSSSCSPRALPVYNKQVSDSCIIRVSVECVSNGNVYKSIVLTSQEHTPQVIQRALEKHNMEDFSCSDFGLYQVLKNGKELQIPDKANVFYAMCPTANYDFVLRQRWRSHGRNFGSSTSPGALPRCRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVL1</accession>
    <name>A0A3P9BVL1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 100</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVL1"/>
    <dbReference type="Ensembl" id="ENSMZET00005014497.1">
        <property type="protein sequence ID" value="ENSMZEP00005014025.1"/>
        <property type="gene ID" value="ENSMZEG00005010572.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154322"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071773">
        <property type="term" value="P:cellular response to BMP stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032536">
        <property type="entry name" value="TMEM100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16100">
        <property type="entry name" value="PHOSPHOINOSITIDE-INTERACTING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16100:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16311">
        <property type="entry name" value="TMEM100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="152" mass="16390" checksum="8825CEFFC8030C6A" modified="2019-02-13" version="1">MPDDLHSKGGGGRVPRSAMKVPPSISAEKLSRDKPRKDRRVVVTTHVPHVNEVQLTAATGGAEMSCYRCTIPFGVVVLIAGIVVTAVAYTFNSHGSTITVLGLVLLSVGLGLLGASAICWKVRQKKKKDKRRESQTALMASHGFNLFYQLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVQ6</accession>
    <name>A0A3P9BVQ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVQ6"/>
    <dbReference type="Ensembl" id="ENSMZET00005014510.1">
        <property type="protein sequence ID" value="ENSMZEP00005014038.1"/>
        <property type="gene ID" value="ENSMZEG00005010561.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161369"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="OR51/52/56-like"/>
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        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
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        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
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        <property type="entry name" value="7tm_4"/>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="OLFACTORYR"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="53"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="104"/>
            <end position="122"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="153"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="43"/>
            <end position="295"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363047"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="323" mass="36454" checksum="253BD90731108FA3" modified="2019-02-13" version="1">MSQDRIVSAQVLFFILGFPGLSPQYYGPISTFLFFVYLAIALGNIFILSFVAYEKSLQKPTYLVFCHLALNDLTFGTVTLPKIMSKYWFDNSDISFYGCFTQMFFVHYLGSVTSFILLVMALDRFVAICIPLRYPVLITNSVISVLCGFAWFIPLPLMIAVVLHALTLPFCKSNIIVQCYCDHISIVSQACGDDVRIVVVTSLCLAMFCLLLPLAFILFSYISIIVVIMKMSSSAGRKRTLSTCTSQIFITCLFYLPRCFVYVANAFGFSFSLDVRIGLILLYSLFPAAVNPVIYCFKTRDIKHMLMKRLKKTKIGLEIKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BW72</accession>
    <name>A0A3P9BW72_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Delta-1-pyrroline-5-carboxylate synthase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="20">Glutamate 5-kinase</fullName>
                <shortName evidence="20">GK</shortName>
                <ecNumber evidence="20">2.7.2.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="20">Gamma-glutamyl kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="20">Gamma-glutamyl phosphate reductase</fullName>
                <shortName evidence="20">GPR</shortName>
                <ecNumber evidence="20">1.2.1.41</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="20">Glutamate-5-semialdehyde dehydrogenase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="20">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>L-glutamate + ATP = L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 20">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Can form homodimers/multimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">In the N-terminal section; belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="20"/>
    <dbReference type="EC" id="1.2.1.41" evidence="20"/>
    <dbReference type="RefSeq" id="XP_004559751.1">
        <property type="nucleotide sequence ID" value="XM_004559694.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BW72"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014107"/>
    <dbReference type="Ensembl" id="ENSMZET00005014580.1">
        <property type="protein sequence ID" value="ENSMZEP00005014107.1"/>
        <property type="gene ID" value="ENSMZEG00005010618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466829"/>
    <dbReference type="KEGG" id="mze:101466829"/>
    <dbReference type="GeneTree" id="ENSGT00500000044903"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04256">
        <property type="entry name" value="AAK_P5CS_ProBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Delta-1-pyrroline-5-carboxylate synthase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Delta-1-pyrroline-5-carboxylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041744">
        <property type="entry name" value="G5K_ProBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005766">
        <property type="entry name" value="P5_carboxy_syn"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01092">
        <property type="entry name" value="P5CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036429">
        <property type="entry name" value="P5C_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 20" id="KW-0521">NADP</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 20" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="22">
        <location>
            <begin position="53"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="21">
        <location>
            <begin position="344"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR036429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="779" mass="85037" checksum="2695ECA259B61072" modified="2019-02-13" version="1">MFARLASCSPLPFRTRQSNVCPVYIRAFSQAKFVLPRPHGKSFAHRSELKQAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVAMLQNQGREMMIVTSGAVAFGKQRLRHEILLSQSVRQALHSGQNQLKDMTVPVLEARACAAAGQSGLMALYEAMFTQYSICTAQILVTNLDFHDEQKRRNLNSTLHELLRMNIVPIINTNDAVVPPPVPNSDLQGVNVISIKDNDSLAARLAVEMKVDLLIALSDVQGLYDSPPGTDDAKLIDIFYPGDQQSITYGTKSRVGIGGMEAKVKAALWALQGGTSVIIANGTDPKVTGHVITDIVEGKKVGTFFSEVKPAGPTVEQQTEMARHAGRTLASLLPEQRGEIICCLAELLTEKKEEILNANRKDMELATTLGRLSQPLINRLSLSTAKLNSLAIGLRQLAVSSRDSVGRVLRRTRVANNLELEQITVPIGVLLVIFESRPDCLPQVSALAIASGNALLLKGGKEASNTNKILHQLTQEALSIHGVADAIQLVSTREEVEDLCRLDKMIDLIIPRGSSQLVREIQRAAKGIPVLGHSEGICHVYVDSDASIDKALDVVKDSKCDYPAACNAMETLLIHRDLLRTPVFDQIIDLLRTEQVKIHAGPRFASYLTFSPSEVKSLRTEYGDLECCIEVVDSMQEAVDHIHKYGSSHTDVIVTENEETAEQFLQQVDSACVFWNASSRFADGYRFGLGAEVGISTARIHARGPVGLEGLLTTKWVLRGEGHTVADFSEQGSMKYLHENIPVPQGSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWQ5</accession>
    <name>A0A3P9BWQ5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein TMEM103</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560225.2">
        <property type="nucleotide sequence ID" value="XM_004560168.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWQ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014420"/>
    <dbReference type="Ensembl" id="ENSMZET00005014900.1">
        <property type="protein sequence ID" value="ENSMZEP00005014420.1"/>
        <property type="gene ID" value="ENSMZEG00005010854.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101466469"/>
    <dbReference type="CTD" id="54859"/>
    <dbReference type="GeneTree" id="ENSGT00390000011734"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001078">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="274" mass="30224" checksum="E20D0A13F076626D" modified="2019-02-13" version="1">MFTELNSILNATPDSFTQGEFILVSDRQSDASFLIHHFLSFYLRARCKVCFLGLVQSFSHYSAISQRLGVSLTQAREKGQLIFLEGLKESLSILIPQETTTGSQAMDFLRDPTVGLQRLYEFVRSSVSSDGGGEEGVEEWGPPVLLVDDISVLLSLGVSAGAALDFSHYCRATVCSQLQGNIVMLVRCHGEEAEDDGSDEGSEWLLKGLTHQCSLTLHVQGLPTGYCRDIHGQVEVCWRRRRGDGQHTQKKLFQYKVHDKGASFFAPGTSSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXW0</accession>
    <name>A0A3P9BXW0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">YY1 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">YY1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YY transcription factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXW0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014739"/>
    <dbReference type="Ensembl" id="ENSMZET00005015224.1">
        <property type="protein sequence ID" value="ENSMZEP00005014739.1"/>
        <property type="gene ID" value="ENSMZEG00005011091.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154763"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000104">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000109">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000163">
        <property type="entry name" value="transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000174">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017114">
        <property type="entry name" value="YY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037113">
        <property type="entry name" value="TF_Yin_yang"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="366" mass="40132" checksum="4396F6262A9BB867" modified="2019-02-13" version="1">MASGDTLYIETDGSEMPAEIVELHEIEVETIPVETIETTVVGGDDDDDDDDGQPMIALQPLVTDDPSSIHHHQEVILVQTREEVVGGDDSDLHTDGGGGFEDQILIPVPAPGVEDEYIEQTLVTVAGKSSVGRVKRGGGTGGKKAGKKSYLSGAEAGGRKWEQKQVQIKTLEGEFSVTMWASDIDHESVVEEQIVGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKVKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY73</accession>
    <name>A0A3P9BY73_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase pellino homolog 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pellino family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BY73"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014938"/>
    <dbReference type="Ensembl" id="ENSMZET00005015426.1">
        <property type="protein sequence ID" value="ENSMZEP00005014938.1"/>
        <property type="gene ID" value="ENSMZEG00005011221.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183050"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO HOMOLOG 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038886">
        <property type="entry name" value="Pellino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="4">
        <location>
            <begin position="46"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="5">
        <location>
            <begin position="294"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="440" mass="48080" checksum="CA9EF824EC84BF8B" modified="2025-10-08" version="2">MVLLINKTSQPDDRPCQGGREGVREEGGGGGGGGEKPFYITSAHNYNGSLPNGDRGRRKSRFALYRRAKANGVKPSAVHILNTPQDSKAVHSRGQHSISFTLSRNQTVVVEYCHDNNTDMFQIGRSTESPIDFVVTDTSGGKEGEDPSIAPSTISRFACRIVCERNPPYTARIYAAGFDSSKNIFLGEKATKWKNPDGHMDGLTTNGVLVMHPQGFPEDPKQGLWREISVCGDVYALRETRSGPSRGTLAEGESSALRDGSLVDLCGATLLWRTGEGLMRSPTLRHLEALRQELNASRPQCPVGLSTLAFPSLPRKRQPWVYLACGHVHGRHDWGQRSEREEDPGEGEGSTTRRECPLCRSVGPYVPLWLGCEPAVYVDAGAPTHGFVPCGHVCSERTAKYWAETPLPHGTHAFRPVCPFCSTALSSPGWTRLIFQGPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYR2</accession>
    <name>A0A3P9BYR2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multidrug and toxin extrusion protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538879.1">
        <property type="nucleotide sequence ID" value="XM_004538822.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYR2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015115"/>
    <dbReference type="Ensembl" id="ENSMZET00005015605.1">
        <property type="protein sequence ID" value="ENSMZEP00005015115.1"/>
        <property type="gene ID" value="ENSMZEG00005011339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483717"/>
    <dbReference type="KEGG" id="mze:101483717"/>
    <dbReference type="GeneTree" id="ENSGT00940000163234"/>
    <dbReference type="OrthoDB" id="8397536at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="583" mass="62417" checksum="44388D60BE1F9FDA" modified="2019-02-13" version="1">MDASVKTAGKCTEAARGDLKEGEVAQSSRGCCQKCVPGFIPTVYRNELVQLFKLAGPVVISQFMIFMIGFVSTVFCGHLGKTELAAVALSIAVVNVTGISIGTGLSLTCDTLISQTYGSGNLKRVGVILQRGVLILLLACFPCWAILINTEPLLLAVKQSPEVASLSQLYVKIFMPALPAAFMYQLQGRYLQNQGIICPQVITGAIGNVFNAIFNYVLIHQLDLGVAGSAAANAISQYLLAAVLFIYMYLRGLHKATWAGWSLDCLQEWGPFVQLAVPSMLMLCLEWWMFEVGGFLAGVISEAELGAQSITYELSILAYMIPLGFASAASVRVGNALGAGNIEQAKLSSKVPIICAFIIACFVSAIFCACKNVIGYIFTSELDILQRVSDIMLVFGFLHLGDAIAGVTGGVVRGVGKQSVGALCNLIGYYFIGLPTGVSLMFAAEMGVVGFWAGLTVCVFVQSIFFITFLCKLNWKKAAEEAEVRAGVRVKEEKDTIKMGNRDSNLIQTPISTIASSGESAEVDHVLMEMQIPEESQTTNTTTVGDVLSVSQLVLRRGLAILIMILILAAGVITNTVLTPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYS4</accession>
    <name>A0A3P9BYS4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">aldose reductase</fullName>
            <ecNumber evidence="8">1.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aldehyde reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alditol + NADP(+) = an aldose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12789"/>
            <dbReference type="Rhea" id="RHEA-COMP:9554"/>
            <dbReference type="Rhea" id="RHEA-COMP:9555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15693"/>
            <dbReference type="ChEBI" id="CHEBI:17522"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin F2alpha + NADP(+) = prostaglandin H2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45312"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57404"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.21" evidence="8"/>
    <dbReference type="RefSeq" id="XP_004560912.1">
        <property type="nucleotide sequence ID" value="XM_004560855.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYS4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015017"/>
    <dbReference type="Ensembl" id="ENSMZET00005015505.1">
        <property type="protein sequence ID" value="ENSMZEP00005015017.1"/>
        <property type="gene ID" value="ENSMZEG00005011270.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477205"/>
    <dbReference type="KEGG" id="mze:101477205"/>
    <dbReference type="GeneTree" id="ENSGT00940000153272"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000009">
        <property type="entry name" value="Aldo-keto reductase family 1 member B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="13">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038955"/>
        </source>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSMZEP00005015017.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="316" mass="35663" checksum="90C05B50258DD6F6" modified="2019-02-13" version="1">MATSVKLNTGAQMPILGLGTWKSPPGKVAEAVKAAISAGYRHIDGAYVYQNEVEVGEGIHTIIKDGVVKREDLFIVSKLWCTFHEKSLVRKGCEKTLSDLKLDYLDLYLVHWPMGFKAGDELFPLDSTGQSISDNTSFLETWEGMEELVDAGLVKAIGISNFKKEQIEAILNKPGLKYKPANNQVECHPYLTQDKLINYCHSQGISVTAYSPLGSPDRPWAKPEDPSLLEDPNIKVIAEKHKKTPAQVLIRFHVQRNVIVIPKSITPQRIQENFQVFDFELTEEEMKTILGFNRNWRVCPMQCATKHKDFPFNAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZ39</accession>
    <name>A0A3P9BZ39_9CICH</name>
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            <fullName evidence="12">B30.2/SPRY domain-containing protein</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZ39"/>
    <dbReference type="Ensembl" id="ENSMZET00005015384.1">
        <property type="protein sequence ID" value="ENSMZEP00005014896.1"/>
        <property type="gene ID" value="ENSMZEG00005011201.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="NACHT" evidence="9">
        <location>
            <begin position="57"/>
            <end position="191"/>
        </location>
    </feature>
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        <location>
            <begin position="744"/>
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        </location>
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        <location>
            <begin position="20"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="939" mass="106293" checksum="F0F7814930982CFE" modified="2019-02-13" version="1">NKIYTELYIIEGGTAEVNEEHEVRQIETASREPDRPETTIRQEDLFKDSSGRDEPIRTVLTKGVAGIGKTVLTQKYTLGWAEDKANQDIQFIFPFTFRELNVLKEERFSLVELVHHFFTETKEAGICSFEDFQVVFIFDGLDECRLPLDFHKTTILTDTRKSTSVYVLVINLIRGKLLPSAHVWITTRPAAANQIPPDCVDMVTEVRGFTDPQKEEYFRKRYREKKQASMIISHIKTSRSLYIMCHIPVFCWITATVLENILKTKKGGQLPKTLTEMYIHFLVVLAKVKKVKYDGGAETDPHWSPESRKMIESLGKLAFHQLQKGNLIFYESDLAECGIDIEAASVYSGVFTQIFKEESGLYQDKVFCFIHLSVQEFLAALHVHLTFINSVVNLLEEQQTSSWWSKFFNAPKLQHVHQSAVDKALQSPNGHLDLFLRFLLGFSLQTNQTLLRGLLTQTGSSSQTNQETVQYIKKKLSQNLSAENSINLFHCLNELNDRSLVEEIQKSLRSGCLPVDKLSPAQWSALVFILLSSEKDLDVFDLKKYSASEEALLRLLPVVKASNKALLNSCNLSERVCQDLFSVLSSQSCSLKELDLSTNSLGDYGVKKLLAVVQSPHCKLNILTLSHSNLSQRSCGALSSILSSQFSSLRELNLSNNDLQDSGVGLLAHGLESPYCTLETLSLSGCLITEEGCTSLASALSSNPSHLRELDLSYNHTGDSGMQLLLAGLKDPHWRLDTLRYGENGPRGYYSKFTTNRRLYSCQLTIDTNTLHTNLKLSDNNRKVIHVEEVQSYPDHPDRFDVWSQLLCTNNLTGRCYWEVEWRGNFYISVSYRRIRRKGRSYDCGFGNNDQSWSLSCCDDGPLRVWHNNKQTPISSSSFSSFYISNRVAVYVDCPAGTLSFYRVSSDTLIHLHTFNTTFIEPLYPGFGVLFPGSSVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZR4</accession>
    <name>A0A3P9BZR4_9CICH</name>
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            <fullName evidence="9">Nocturnin</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <organism evidence="12 13">
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        <lineage>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
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                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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            <dbReference type="PubMed" id="25186727"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538858.1">
        <property type="nucleotide sequence ID" value="XM_004538801.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004538859.1">
        <property type="nucleotide sequence ID" value="XM_004538802.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004538860.1">
        <property type="nucleotide sequence ID" value="XM_004538803.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004538861.1">
        <property type="nucleotide sequence ID" value="XM_004538804.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004538862.1">
        <property type="nucleotide sequence ID" value="XM_004538805.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004538863.1">
        <property type="nucleotide sequence ID" value="XM_004538806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZR4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015475"/>
    <dbReference type="Ensembl" id="ENSMZET00005015966.1">
        <property type="protein sequence ID" value="ENSMZEP00005015468.1"/>
        <property type="gene ID" value="ENSMZEG00005011616.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005015973.1">
        <property type="protein sequence ID" value="ENSMZEP00005015475.1"/>
        <property type="gene ID" value="ENSMZEG00005011616.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478528"/>
    <dbReference type="CTD" id="568973"/>
    <dbReference type="GeneTree" id="ENSGT00940000155249"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09096">
        <property type="entry name" value="Deadenylase_nocturnin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000012">
        <property type="entry name" value="nocturnin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034965">
        <property type="entry name" value="Deadenylase_nocturnin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="95"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="393" mass="44095" checksum="3CEFE0E6C8D24DE1" modified="2019-02-13" version="1">MGGGATKLYNALTQPLSSTSSLLPFPSSHLNPQLPAFTKLDPDFCPEGSSPCPPDPEELLRQCEEALTDRPPRFDRKFVHIGDGDGAPSSVIRVMQWNILAQALGEGLDNFVMCPLEALSWSRRKYLIMEEVLTYRPHIVCMQEVDHYYDTLQPVLAGLGYSSHFCPKPWSPCLGVEGNNGPDGCALFYDESRFELLDSVNIRLSAMRIPTNQVAIVTTLRCRITGKCVCVAVTHLKARSGWEWLRSTQGSDLLWHLQNVVQKQPGAPAADIPLLICGDFNAVPNEEVYRRFATSPFGLDSAYKKLSRDGLTEPEYTTWKIRPTGECCSTLDYIWYTKDTLRVDAVLDMPTEEEIGPNRLPSFSYPSDHLSLVCDFSFKEEEWEGNNKPAHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0Y5</accession>
    <name>A0A3P9C0Y5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004541693.1">
        <property type="nucleotide sequence ID" value="XM_004541636.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0Y5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015824"/>
    <dbReference type="Ensembl" id="ENSMZET00005016334.1">
        <property type="protein sequence ID" value="ENSMZEP00005015824.1"/>
        <property type="gene ID" value="ENSMZEG00005011886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477606"/>
    <dbReference type="KEGG" id="mze:101477606"/>
    <dbReference type="CTD" id="51805"/>
    <dbReference type="GeneTree" id="ENSGT00390000007284"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018126416" description="Ubiquinone biosynthesis O-methyltransferase, mitochondrial" evidence="6">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="338" mass="37259" checksum="B2F2BDE4A98BF6DE" modified="2019-02-13" version="1">MYSNKFRRLMLGLHCLKTTAVCGLVQRAAGRSGFGWTAVCKQRTLWLQRSACREIERRAVLRQNGVRSASHSTVDPDELRKFQSLANKWWDEQGEFAALHAMNDLRVPFIRDNLLNVHRARHPGKPLAGLKILDVGCGGGLLTEPLGRLGAKVLGIDPVENSIGTAQLHSSFDPDLCERVSYQVCTLEELSGGEDEGAGHFDAVVASEVVEHLADLETFAFCCSQVLKPGGSLFITTINKTNLSYVLGIVVAEQLLRIVPDGTHDWEKFVSPVDLERLLESHGFSVQSVKGMLYNPLSGAWSWTDSTAINYALHAVKLRKQAEDSSLHPEDHTIESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3K8</accession>
    <name>A0A3P9C3K8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">2-oxoglutarate dehydrogenase complex component E1</fullName>
            <ecNumber evidence="6">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Alpha-ketoglutarate dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:12189"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004569447.2">
        <property type="nucleotide sequence ID" value="XM_004569390.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3K8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016712"/>
    <dbReference type="Ensembl" id="ENSMZET00005017246.1">
        <property type="protein sequence ID" value="ENSMZEP00005016712.1"/>
        <property type="gene ID" value="ENSMZEG00005012539.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101473303"/>
    <dbReference type="CTD" id="797715"/>
    <dbReference type="GeneTree" id="ENSGT00950000183125"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase e1 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000001">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF7">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018063305" description="2-oxoglutarate dehydrogenase complex component E1" evidence="23">
        <location>
            <begin position="23"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="24">
        <location>
            <begin position="651"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114813" checksum="92A73B400C998B94" modified="2019-02-13" version="1">MHRLRTTVVRLWPLTAVQMAQSLSKPVPLAVKQGLRTSQPARHLNTPLASEPFLNGTSSNYVEEMYYTWLENPKSVHKSWDVFFRNASAGAPPGAAYQGPPHLSRTSERLSSAQALVGTQPSVEKLVEDHLAVHSLIRAYQVRGHHIAKLDPLDISCVDFDDAPCTIGFQNVGIYGLAESDLDKVFQLPTTTFIGGNESALPLREIIYRLERAYCQHIGVEFMFINDMEQCQWIRQKFETPGVMQCTLEEKRTLLARMIQSTRFEEFLQRKWSSEKRFGLEGCESLIPALKTIIDKSSQSGVESVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRMNRVSDKYMTLSLVANPSHLEAVDPVVQGKTKAEQFYCGDTEGKRVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTIHVVVNNQIGFTTDPRVARSSPYPTDVARVVNAPIFHVNGDNPEAVMYVCKVAAEWRNTFHKDVVVDLVCYRRNGHNEIDEPMFTQPLMYKRIKKQKGVLQKFVEKLIDEGVVTTQEYEEEVASYDKICEEAYTRSKDEKILHIKHWLDSPWPGFFTLEGQPRSMTCPSTGISEQALSHIGNIAASVPVQDFAIHGGLSRILKGRANMVSQRLCDWALGEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQNTDKRMCIPMNYISPDQAPYTVCNSSLSEYAVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFISSGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVFPKLSEDFAMHQLYDCNWIVVNCSTPANYFHVLRRQILLPFRKPLIVLTPKSLLRHPEVKSSFDDMLPGTHFRRLIPDNGHTATNPEKVKRLIFCTGKIYYELTRERKNRGMDEAIAVVRIEQLSPFPFDLVKEEADHYPNADLVWCQEEHKNHGYYDYVKPRISTTIGHTRPICYAGREAAAAPATGNKHTHKMELQYLLDTALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3L6</accession>
    <name>A0A3P9C3L6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP206 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3L6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016639"/>
    <dbReference type="Ensembl" id="ENSMZET00005017172.1">
        <property type="protein sequence ID" value="ENSMZEP00005016639.1"/>
        <property type="gene ID" value="ENSMZEG00005012455.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016036"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003356">
        <property type="term" value="P:regulation of cilium beat frequency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901317">
        <property type="term" value="P:regulation of flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12018">
        <property type="entry name" value="FAP206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="609" mass="68597" checksum="5D69BFBA08FE7913" modified="2019-02-13" version="1">MSQAGAETLLKTVIGHIVHECRLRGHAVSETLAAFMVSAVVLDPRNGFNVDRTLTKDDVQKLEELCLDKLTEKCSPSLDTIKMQVCFDMNYTTKCEFLEDIHQSEESKLSPLCREITDNRVKSRKELDGLYQKITTYILQRSAMGSPTDTNTMEEATAVLQSVFPQAELGNFRVALKRDQEQQLKELTMIVTGIRLFNKANKRGEEEVDIHELILQEALPVTSKSIANELCVTQTLVFKYTVVLEKLTSSDVQLGHSDMPVILLKQALYNARQHEVFLKMLLADANSCAKHVETLLSDVSSQMKMLKETVQSKTAVPAATVFVSCFVLKECLSLQVWLWSPTETKLHFPQELQKREIKIYAFASLKCGCDLFCLSDNCVDPASLKTQEWLFPETTVNFEEMPLQYNGFCGYTLVTRDGLLLPGNPYIGALKHKEKLYVFTSKEAAMKFALSPDSFVAEVAEKAKYSPELIQLLKLHQQFSCISPYSDVSRLSQGLPVKPGIKCECGTQTEIHPVEKNIVKSYEWNEWELRRKALKLANLQTRVTVSVQTDLSHMRRENVTQTWLPKNAACQSKRDGASQVPKPQTFVAGLRGQRGAHVVKANLTRSVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C615</accession>
    <name>A0A3P9C615_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP domain-containing protein 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the THAP11 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C615"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017331"/>
    <dbReference type="Ensembl" id="ENSMZET00005017878.1">
        <property type="protein sequence ID" value="ENSMZEP00005017331.1"/>
        <property type="gene ID" value="ENSMZEG00005013030.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006585"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22291">
        <property type="entry name" value="cc_THAP11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="273" mass="29256" checksum="38D84DB491F589AB" modified="2019-02-13" version="1">MPGFTCCVPGCYNNSHRDRELRFYTFPKDTALREQWLRNISRAGVSGCFSTFQPTTGHRVCSVHFAGGRKTYSIRVPSLFPLRGVNERRSRRGRGRKVSAAVPAPAAAATSGIVVTSSVLGSTAEGAEANAGGEASDDSITVVQIGQNGEYLGTARLPVQTEGTSYTGQVGGTAEVTAGDSQVDTSSAAAPVQYVSVTSSPLDHSYSLTTGTTSAELLRKLNEQRDIIALMEVKMKEMKATIRQLRVAEAKLQEEVRERDRLLLGALVAKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CA10</accession>
    <name>A0A3P9CA10_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Paired box 7a</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CA10"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018736"/>
    <dbReference type="Ensembl" id="ENSMZET00005019337.1">
        <property type="protein sequence ID" value="ENSMZEP00005018736.1"/>
        <property type="gene ID" value="ENSMZEG00005014047.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050938">
        <property type="term" value="P:regulation of xanthophore differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000080">
        <property type="entry name" value="paired box protein Pax-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000035">
        <property type="entry name" value="paired box protein Pax-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000031">
        <property type="entry name" value="Paired box protein Pax-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022106">
        <property type="entry name" value="Pax7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF26">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12360">
        <property type="entry name" value="Pax7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="15">
        <location>
            <begin position="34"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="217"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="14">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="297"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAS9</accession>
    <name>A0A3P9CAS9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAS9"/>
    <dbReference type="Ensembl" id="ENSMZET00005020026.1">
        <property type="protein sequence ID" value="ENSMZEP00005019398.1"/>
        <property type="gene ID" value="ENSMZEG00005014561.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176837"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF8">
        <property type="entry name" value="C-TYPE MANNOSE RECEPTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="145" mass="17071" checksum="831D0A41433C423D" modified="2019-02-13" version="1">MVLQVDYGLFDNKKWRDAHADHINPVFCYSTVVVEEEKTWEEALEYCREHHDDLASVASETEMLLIQKELNKYHTTKHVWIGLRFLSKDWIWVDGQEMDYEAWDEGGKPLCPQAKMKCAALQKTGGRLSSWRAHDCEKRLSFICY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBE4</accession>
    <name>A0A3P9CBE4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAM domain containing 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014262732.1">
        <property type="nucleotide sequence ID" value="XM_014407246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBE4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019437"/>
    <dbReference type="Ensembl" id="ENSMZET00005020065.1">
        <property type="protein sequence ID" value="ENSMZEP00005019437.1"/>
        <property type="gene ID" value="ENSMZEG00005014591.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484352"/>
    <dbReference type="KEGG" id="mze:101484352"/>
    <dbReference type="GeneTree" id="ENSGT00940000156117"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000128">
        <property type="entry name" value="enteropeptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MAM_dom"/>
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    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAM"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MAM_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="49"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="199"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="377"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="546"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="718" mass="80144" checksum="89C828AF68F44180" modified="2019-02-13" version="1">MKEDCSLFFSYILQEFSLYIFKQKAAMLRFYILLTFAVNIQANSQLLPGSCNFESNTCGYTSDADFMSWTLQKDGRFVTVEAAVNEDQEDYIGSGADPQREIIGVLLSPRLEHGEWSCLRLVYQITEPGSLEVLQRTEGNSFDRPLWSSRLPSDSWVVSSIDLQNNTEPYRVVIEGKPGSSKGSSVAIFEIHISPGYCLECDFEESHLCGYNNQWNANVNWYVGGGGVQVLHNAMPNDHTYNNGSGHFMYVDSIYGKTFKEVAKLVSPMTQVPMSGCLSFQYQRSEMGNLFSVFTRDQLGQYQELWRAGLENQNDWTEIPGEWIPVQVDLKAPYSVQVVFEVAFNSPRGGRVALDDISFSSQFCTTDTEPTFDPSIANCDFESGFCLYTQEQAKESPWRRVSVKPNIFRNGDHTTGAGSFLLAHSRLGPRSGYVSRLIGPTLAGNMKYCLTFYFSLRGFNQTDQALAVYLLHANGSQEKIWTQAERSRGIWIAADVTFQTSQSAKVVFVSTCRSFWDCGSVALDDISVSLGDCELVAGLLSSLLPGRCDFEAGLCGYTQDKKSDAADWERRRGATPTSYTGPRGDHTAGLGYYLHLEASPMLPGQNARLMSRTVRGTRGRHCVSFFYHMYGSGTGQLNVRINKYGKEELLWQRSGEQSIAWLKAQVEYQCHSQHQIVFEAIRGSSIRSDIAIDDVILEGGPCPEMGISTTVGTSNEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBN2</accession>
    <name>A0A3P9CBN2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tensin 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBN2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019414"/>
    <dbReference type="Ensembl" id="ENSMZET00005020042.1">
        <property type="protein sequence ID" value="ENSMZEP00005019414.1"/>
        <property type="gene ID" value="ENSMZEG00005014570.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155400"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000002">
        <property type="entry name" value="tensin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF3">
        <property type="entry name" value="TENSIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="3">
        <location>
            <begin position="181"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42061" checksum="FE4BF2B99632576E" modified="2019-02-13" version="1">MSVVQAMEESYEVDLVYITERIISVSFPAGAEEQSYNTNLKEVATMLRSKHGEHYLVLNLSEGQSDLTKLNHKVLEFGWPDHHAPALDKICSMCKAIDMWLNGDTRNVVVLHNKGNRGRTGVVVAAYMHYSNISASADQALDRFAMRRFYEDKALPVGQPSQRRYVRYFNGLLSGHIKINNKPLFLHHVIMHGIPNFESKGGCRPFLKIYQAMQPVYTSGIYNVQGDSNTSICITIEPGLLLKGDILLKCYHKRYRSPTRDVVFRVQFHTCAIHDLGVVFGKSELDETFKDERFPEYGKVEFVFSYGPEKIKGLSHLENGPSVSVDYNTQDPLIRWDSYESFSHRCEEAADADHGMQMTYSDYFGEAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBX0</accession>
    <name>A0A3P9CBX0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Meis homeobox 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/MEIS homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBX0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019783"/>
    <dbReference type="Ensembl" id="ENSMZET00005020415.1">
        <property type="protein sequence ID" value="ENSMZEP00005019783.1"/>
        <property type="gene ID" value="ENSMZEG00005014838.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155643"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003209">
        <property type="term" value="P:cardiac atrium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000004">
        <property type="entry name" value="Meis2 homeobox isoform 2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="265"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="267"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="383" mass="42143" checksum="E3FDB5ED0B7AB5F4" modified="2019-02-13" version="1">LSLQYDELTHYGGAMDGVPGSMYGDPHAPRPLPQLHHLSHGAPPHPTQHYGAHAPHNIMGSSVSDALKRDKDQIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIEERDVCKSDFDDLSGSSTNLADHNPASWRDMDDSHSTPSVGTPGPSSGGHVSQSGDNTSELGDGLDNSLASPGTGDEDDQDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGSGTAYSPDGQPMGGFVLDGQQHMNLRPGPMGSMGMNMGMDGQWHYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CC13</accession>
    <name>A0A3P9CC13_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Synaptosome associated protein 91b</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CC13"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019662"/>
    <dbReference type="Ensembl" id="ENSMZET00005020292.1">
        <property type="protein sequence ID" value="ENSMZEP00005019662.1"/>
        <property type="gene ID" value="ENSMZEG00005014754.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183068"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098894">
        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16985">
        <property type="entry name" value="ANTH_N_AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000001">
        <property type="entry name" value="phosphatidylinositol-binding clathrin assembly protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF28">
        <property type="entry name" value="CLATHRIN COAT ASSEMBLY PROTEIN AP180 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="6">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="220" mass="24874" checksum="0BFB2CB57A4EA64B" modified="2019-02-13" version="1">MSGQTLTDRIAAAQYQLTGSDMARAVCKATTHEVMAPKKKHLEYLVSATNTTNVNIPQMADTLFERSTNASWVVVFKALVTTHHMCVYGNERFIQYLASRTSLFNLSNFIDKTGSHGYDMSTFIRRYGRYLNEKAFAYRQMAFDFTRVKKGADGVMRTMTTEKLLKGMPVLQTQIDTLLEFDVHPKELNNGIINAAFLLLFKDLVKLFASYNDGIINLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCA0</accession>
    <name>A0A3P9CCA0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inactive serine protease 35</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CCA0"/>
    <dbReference type="Ensembl" id="ENSMZET00005020139.1">
        <property type="protein sequence ID" value="ENSMZEP00005019511.1"/>
        <property type="gene ID" value="ENSMZEG00005014648.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000155"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF17">
        <property type="entry name" value="INACTIVE SERINE PROTEASE 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0721">Serine protease homolog</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017935881" description="Inactive serine protease 35" evidence="9">
        <location>
            <begin position="35"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="146"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="490" mass="54675" checksum="992C49578E0E12BF" modified="2019-02-13" version="1">MGVLIYFICSGMALTHLKCVLLCVAALSASGVFGNSESNEVHRWTRQSLPELVATRTALLRTPLFTGKEEEKEELERRAAKMLCGIECQSTLPPVDQTEQERNLGYETLYENGTRTHTDMSLQGINKMSTRPPAHSTGLPRRKRQVYGADGRFVISDSHFITNYPFSAAVRISTGCSGVLISSKHVLTAAHCIHDGRDYLEGARKVRVGLLQLKTTRGSGGRRRGGRRRQGRKGGAEKREKEGEEKLMDGGGEMNSLVGERGRKGVEGRRRRGRKRAEEGTADGGDKKSERRGRRKGLNRVRRSTGATQKPVFRWTRVKQTKIPKGWIHTQNSTNSLSPDYDYALLELKRPVKQKHMELGVAPSTAPLTRIHFSGYDADKNLPDGIGDERVVYRFCSVAKESDDLMYQHCDAQTGATGAGVYIRLRQEAGHTGSKGKWKRRVIGVFSGHHWVKVEGGEQRDFNVAVRITPPKYAQICHWIHGDPSLCKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDE5</accession>
    <name>A0A3P9CDE5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 35 member G1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 20</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with STIM1; stimulated by depletion of intracellular calcium. Interacts with ORAI1. Interacts with the plasma membrane calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1, ATP2A2, KPNB1 and XPO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TMEM20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567571.2">
        <property type="nucleotide sequence ID" value="XM_004567514.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDE5"/>
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            <begin position="118"/>
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            <begin position="362"/>
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        <location>
            <begin position="386"/>
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            <begin position="26"/>
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            <begin position="26"/>
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        <location>
            <begin position="61"/>
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        <source>
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        <source>
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</entry>
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            <fullName evidence="2">Chemokine interleukin-8-like domain-containing protein</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <begin position="20"/>
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        </source>
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        <source>
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        <source>
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    </evidence>
    <sequence length="71" mass="8220" checksum="659285942E95839B" modified="2019-02-13" version="1">MTLSNPCFSVTAKAVNSPEVCCFEFFDKRIPKANIVSIVKTHNQCATPAFIQMKIVHKLEMFSYFWIQLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGM2</accession>
    <name>A0A3P9CGM2_9CICH</name>
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        <recommendedName>
            <fullName evidence="2">ribonuclease H</fullName>
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        </recommendedName>
    </protein>
    <organism evidence="5 6">
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        <name type="common">zebra mbuna</name>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
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                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
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                <person name="Williams L."/>
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                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGM2"/>
    <dbReference type="Ensembl" id="ENSMZET00005022133.1">
        <property type="protein sequence ID" value="ENSMZEP00005021425.1"/>
        <property type="gene ID" value="ENSMZEG00005016088.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064449"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF80">
        <property type="entry name" value="ENVELOPE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="677" mass="74523" checksum="6E4DC5251824A695" modified="2019-02-13" version="1">MLIQYVDDLLLSAPTADICLEATRVVLQHLADTGFKVSKTKLQIARKQVSFLGRMVSQSGISLSPEHRNSILHHPKPLTVKDMLSFLGLTGYSRTYVPDYVGLTSPLRALVNEQGMRNLSAPLSWTTETEQAFIKLKQQLSVASDLAVPDYALPFHLDVSGTGTHINGILFQKKGGERKVLTYVSVMLDNTEKRHPPCTQHVSGLAKIIQKTAHIVMNHPLKILTSHSVVAYVSSQAFTLTSLRQRRLSTILEAPHITYSHEATNNWLLLAEQAADKTASDCIVCMGARPTLRVVPAPVNSACLLHLMNNTKRGHCSYLENHFPKTQRSVSNKPPFFSSDVAVNNFTCINLTGNAVKLGSLNSSWCTEMTVMKPNFRPTARADLWWWCGNNKLYDGFPRDASGLCALITLILPVLVTPVDLSIKVHEVGHPSSSERRSKRSLIPGSAHNPTYIDAVGIPRGVPDEYKLRDQVKAGWASILWMVEINANVDRINYIHFNVQLLANYTRDGFEAVHAQLSATSLMAFQNRVATDFLLAEKGGVCSLFGQECCTYIPNNTAPDGSLTKAITGLTALTVKMKEHSGVDTAMWDSWLNMFGKYKALVASILVSISVFVAILVTCGCCCIPCIRSLFQRLIVTALAPEDKDLARQMPLLAFPPDYVKPVNDTLDLVSGTNVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGR0</accession>
    <name>A0A3P9CGR0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGR0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021483"/>
    <dbReference type="Ensembl" id="ENSMZET00005022192.1">
        <property type="protein sequence ID" value="ENSMZEP00005021483.1"/>
        <property type="gene ID" value="ENSMZEG00005016123.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165675"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000025">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000188">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF177">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1004"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="818"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="371"/>
        </location>
        <ligand>
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        <location>
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        <ligand>
            <name>ATP</name>
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</entry>
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    <accession>A0A3P9CHJ5</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <sequence length="130" mass="15257" checksum="B7D45DD52A23A661" modified="2019-02-13" version="1">MVDKDFAEINALQKVFPESAILLCWYHVLQAVNRWLSKSESGVHGLSNTQKRNEIISFFCKLKACTSVSEDDFKATSAEFCQTFKQYPLVCQYFQKHWEGIGHMWCDYGRRFSHARSETNNVIERYDLLF</sequence>
</entry>
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            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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                <person name="Streelman J.T."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004569183.1">
        <property type="nucleotide sequence ID" value="XM_004569126.1"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A3P9CI87"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021872"/>
    <dbReference type="Ensembl" id="ENSMZET00005022589.1">
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        <property type="gene ID" value="ENSMZEG00005016390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473890"/>
    <dbReference type="KEGG" id="mze:101473890"/>
    <dbReference type="GeneTree" id="ENSGT00940000157821"/>
    <dbReference type="OrthoDB" id="8399014at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23318">
        <property type="entry name" value="beta-trefoil_FGF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000033">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0339">Growth factor</keyword>
    <keyword evidence="8" id="KW-0497">Mitogen</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="208" mass="23314" checksum="3DFAF6D6E25ABA86" modified="2019-02-13" version="1">MAVAQRLLVSMSCEAGTPHWTLTAVVLLGFLLGIVSAYPLPSSRTNATLLEKRWETLFSRSVLGISGEKPELNWESDYLLGIKRVRRLYCNVGIGFHLQILPDGRINGVHNENQYSLIEISTVERGVVSLYGVKSELFVAMNSRGRLYGTTVFHDECKFKESLLANNYNAYESLVYRGSYIALSKHGRVKRGNKATTAMTVTHFLPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLK7</accession>
    <name>A0A3P9CLK7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha/beta hydrolase domain-containing protein 17C</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic density membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the AB hydrolase superfamily. ABHD17 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004568739.1">
        <property type="nucleotide sequence ID" value="XM_004568682.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLK7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022967"/>
    <dbReference type="Ensembl" id="ENSMZET00005023722.1">
        <property type="protein sequence ID" value="ENSMZEP00005022967.1"/>
        <property type="gene ID" value="ENSMZEG00005017197.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474457"/>
    <dbReference type="KEGG" id="mze:101474457"/>
    <dbReference type="CTD" id="58489"/>
    <dbReference type="GeneTree" id="ENSGT00940000159424"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000008">
        <property type="entry name" value="Alpha/beta hydrolase domain-containing protein 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF55">
        <property type="entry name" value="ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="17">
        <location>
            <begin position="97"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="294" mass="32823" checksum="2B9E663E3EE608F6" modified="2019-02-13" version="1">MPEQGPRMNGFSIGELCWLFCCPPCPSRIAAKLAFLPPEPTYSMHTDANGVTSLHLTERADWQYSQRELDAVEVFTTRSSRGNRVACMFVRCAPNSRYTLLFSHGNAVDLGQMCSFYIGLGSRINCNVFSYDYSGYGVSTGKPSEKNLYADIEAAWQMLRNKYGVTPENIILYGQSIGTVPTIDLAARYECAAVILHSPLMSGLRVAFPDTRKTYCFDAFPSIDKVSKVASPVLVIHGTEDEVIDFSHGLAMYERCPRAVEPLWVEGAGHNDIELYAQYLERLKQFISFELSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNI7</accession>
    <name>A0A3P9CNI7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein 469</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN 469"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQ05</accession>
    <name>A0A3P9CQ05_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Pore-forming subunit of a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Voltage-gated sodium (Nav) channels consist of an ion-conducting alpha subunit which is functional on its own associated with regulatory beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Cell membrane</location>
            <topology evidence="1 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005024157"/>
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        <property type="protein sequence ID" value="ENSMZEP00005024157.1"/>
        <property type="gene ID" value="ENSMZEG00005018065.1"/>
    </dbReference>
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        <property type="component" value="LG23"/>
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        <property type="term" value="C:synapse"/>
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        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
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    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
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        <property type="term" value="P:neuronal action potential"/>
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        <property type="term" value="P:regulation of glycolytic process"/>
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        <property type="term" value="P:regulation of locomotor rhythm"/>
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    </dbReference>
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        <property type="term" value="P:regulation of oxidative phosphorylation"/>
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        <property type="term" value="P:swimming behavior"/>
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        <property type="term" value="P:synaptic signaling"/>
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        <property type="entry name" value="IQCD"/>
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        <property type="entry name" value="Na_channel_gate"/>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="EF-hand"/>
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        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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        <property type="entry name" value="IQ_SCN5A_C"/>
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        <property type="entry name" value="Na_trans_assoc"/>
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        <property type="entry name" value="Na_trans_cytopl"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NACHANNEL"/>
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        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 22" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 22" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="16 22" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 22" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9 22" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="121"/>
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    <feature type="transmembrane region" description="Helical" evidence="22">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
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            <begin position="219"/>
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    <feature type="transmembrane region" description="Helical" evidence="22">
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            <begin position="246"/>
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    <feature type="transmembrane region" description="Helical" evidence="22">
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    <feature type="transmembrane region" description="Helical" evidence="22">
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    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="957"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1258"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1289"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1335"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1457"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1538"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1568"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
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    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="125"/>
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    </feature>
    <feature type="domain" description="Voltage-gated Na+ ion channel cytoplasmic" evidence="26">
        <location>
            <begin position="556"/>
            <end position="706"/>
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    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="756"/>
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    </feature>
    <feature type="domain" description="Sodium ion transport-associated" evidence="25">
        <location>
            <begin position="994"/>
            <end position="1212"/>
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    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1217"/>
            <end position="1489"/>
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    </feature>
    <feature type="domain" description="Ion transport" evidence="24">
        <location>
            <begin position="1537"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="domain" description="SCN5A-like C-terminal IQ motif" evidence="27">
        <location>
            <begin position="1904"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="28"/>
            <end position="61"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="465"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1129"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1961"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1970"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1985"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055248"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064899"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU361132"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
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    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF06512"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF11933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2010" mass="227827" checksum="4E9B9C5C1302B7EB" modified="2019-02-13" version="1">MAQLLIPPGPDSFRPFVPESLAAIERRIAEEEAQRPRVERRSDSDDENGPKPNSDVEAGKSLPFIYGDIPPGLVSTPLEDIDPYYSSQKTFIVLNRGKAIFRFNATPALYILSPFNPLRRIAIKVLVILIMFTILTNCAFMTLSNPPDWAKNVEYTFTGIYTFESLIKILARGFCVGKFTFLRDPWNWLDFSVILMAYVTEFVDMGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVRIPLGSNTTLNNTHESNNTLVENITLVENVTFMENITKNSFDWIEYINDERNYYYLPGRRDALLCGNGSGAGVCPEGFSCLKAGRNPDYGYTSFDTFSWAFLSLFRLMTQDYWENLYQQTLRAAGKPYMIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQATIEEAQQKEEEFQAMLEQLKRQQEEAQVAAAAATESGEYSGRGRPTSESSSGTSKLSSKSAKERRNRRKKRKQREEEEERGCRDKFHKSESEDSIKRSSFRFSIDANRLSYEKRCSSPNQSLLSIRGSIFSPRRNSRASLFSFRGRARDMGSENDFADDEHSTFEESDSRRGSLFLPRRLERRCSAVSQTSLGAPRIMLPANGKMHCAVDCNGVVSLVGGTSATTSPVGLLLPEGTTTDTELKKRRSGFHQPSMDYLNEPGGRQRAMSVASILTNTMEELEESRQKCPPCWYRFANTGLIWDCCPAWLKIKEIVSMVVMDPFVDLAITICIVLNTLFMAMEHYPMTEEFDNVLSVGNLVFTGIFTAEMCFKIIALDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQMFGKNYKECVCKISEDCMLPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDEDSEMNNLQIAVGRIQRGIAFVKNAVRQFLQSLCFGRGGKGSGLAEESKPLDELHSNGKGNCISNHTTVEITKDPSGVYMREGNGRPGGLVVGVSVGRDSTGKYPVEDCDYMSFIHNPSLTVTVPIAVGESDFENLNTEDFSSDSSDVEGSKEPLSSSEGSTVDIRPPGDGVDSVELEPEESLDPEACFTEGCVRRFQCCQISEEGDKFKSWWTLRKTCFIIVEHNWFESFIIFMILLSSGALAFEDIYIEQRRTIKTVLEYADKVFTYVFILEMLLKWVAYGFVKYFTNAWCWLDFLIVDVSLVSLVANALGYSELSAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYYYCVNATTDEPFPSEVVNNKSDCLSLNDSARWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDLEEQPKYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKISQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPTNAFQGCVFDFITKQAFDIVIMILICLNMVTMMVETDAQTKEMDHILYWINLVFIVLFTGECVLKMISLRHYYFTIGWNIFDFVVVILSIVGMFLSEVIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNKRDPDCESQLEHPGNSYKGNCGNPSVGIFFFVSYIIICFLIVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWERFDPDATQFVAYSKLSDFADALDPPLRIPKPNMIQLISMDLPMVSGERIHCLDILFAFTKRVLGEGGEMDMLRGQMEDRFMASNPSKVSYEPITTTLRRKQEEMSAIIIQRAFRRYMIRLAMKKASALYKEQLKEGMHDPDKDVMVISKFNENSTSEKMDMTPSTASPPSYNSVTKSDKDKYEKENRERENKAKDLKDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQD5</accession>
    <name>A0A3P9CQD5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQD5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024568"/>
    <dbReference type="Ensembl" id="ENSMZET00005025371.1">
        <property type="protein sequence ID" value="ENSMZEP00005024568.1"/>
        <property type="gene ID" value="ENSMZEG00005018368.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164656"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001935">
        <property type="term" value="P:endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF7">
        <property type="entry name" value="SI:DKEY-228B2.6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="184" mass="21675" checksum="DD9DBB0A4C2FEF88" modified="2019-02-13" version="1">MIVFSIVYCTIKHCTKKYVPKFNGILSFHAFPTHSNLRRQWLVNIRRDHFTITSHTRVCCRHFASDQLIEPTTLDGRRRLIKGAVPTLFEWNGYKVEPPRHSVWERTERRPELVPPDDQEEHSLTRDHDYCSVPEPSALDISASAAEDVETLRKEIQELRVQREFGLQRFAGSDTDIRFYTRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CS52</accession>
    <name>A0A3P9CS52_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome 26S subunit, non-ATPase 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the lid subcomplex of the 19S proteasome regulatory particle complex (also named PA700 complex). The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570357.1">
        <property type="nucleotide sequence ID" value="XM_004570300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CS52"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025185"/>
    <dbReference type="Ensembl" id="ENSMZET00005026004.1">
        <property type="protein sequence ID" value="ENSMZEP00005025185.1"/>
        <property type="gene ID" value="ENSMZEG00005018796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476208"/>
    <dbReference type="KEGG" id="mze:101476208"/>
    <dbReference type="GeneTree" id="ENSGT00530000063301"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
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    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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            <begin position="228"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025185.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="422" mass="47114" checksum="88E20EAED860C5A6" modified="2019-02-13" version="1">MAAAAVAEFQRAQSLLGTDRNASIDILHSIVKRDIQDSDEEAVRVKEQSILELGGLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKAEKRTFLRQALEARLISLYFDTKCYQEALQLGSQLLQELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQAALDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPRAITALKYMLLCKIMLNAPEDVQALISGKLALRYAGRQTDSLKCVAQASKNRSLADFEKALTEYKAELRDDPIISTHLTKLYDNLLEQNLIRVIEPFSRVQIAHISSLIKLSKGDVERKLSQMILDSKFHGILDQGEGVLIVFDEPVVDKTYEAALETIQNMSKVVDSLYNKAKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CU11</accession>
    <name>A0A3P9CU11_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Purinergic receptor P2Y11</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_023008314.1">
        <property type="nucleotide sequence ID" value="XM_023152546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CU11"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025301"/>
    <dbReference type="Ensembl" id="ENSMZET00005026123.1">
        <property type="protein sequence ID" value="ENSMZEP00005025301.1"/>
        <property type="gene ID" value="ENSMZEG00005018887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="111500535"/>
    <dbReference type="KEGG" id="mze:111500535"/>
    <dbReference type="CTD" id="5032"/>
    <dbReference type="GeneTree" id="ENSGT01030000234518"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045031">
        <property type="term" value="F:G protein-coupled ATP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231:SF46">
        <property type="entry name" value="P2Y PURINOCEPTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231">
        <property type="entry name" value="PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="305" mass="34613" checksum="8D6B4E9901BFBF15" modified="2019-02-13" version="1">MLSNFSKCEKFQTGALPVVYGVEFVVALAGNLFALWLLVVKERRNWHTGVVLSCNLAISDLLYVLTLPLLIVYYSKDKHWMFGDAVCKLEKFLFTCNLYVSIFFIMAISVNRCVALACPFFTRSYITPGHAKVTSIVIWVIVGVISSPVLKFASVCSDGSNNKIQCVSFCNKTEHPHYVYKFFLSMFGCLFPFLVTFTSYCVVIWVVWKNVNITPLEKRKVALLVASVLVLYAISFVPYHFFQIYHLHLRLLHPDNTVCWIYDMYQVSKGLATVNMCIHPVLYMAVFDSMRVACCGKSSEDNIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CU60</accession>
    <name>A0A3P9CU60_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ELKS/RAB6-interacting/CAST family member 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="13" key="3">
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        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Cytoskeleton</location>
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        <subcellularLocation>
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            <begin position="19"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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            <dbReference type="ARBA" id="ARBA00034106"/>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS51511"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
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            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CU96</accession>
    <name>A0A3P9CU96_9CICH</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004557248.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMZET00005026777.1">
        <property type="protein sequence ID" value="ENSMZEP00005025940.1"/>
        <property type="gene ID" value="ENSMZEG00005019345.1"/>
    </dbReference>
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        <property type="component" value="LG23"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018016722" evidence="3">
        <location>
            <begin position="25"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
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            <begin position="25"/>
            <end position="95"/>
        </location>
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            <begin position="143"/>
            <end position="244"/>
        </location>
    </feature>
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            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
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            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
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            <end position="177"/>
        </location>
    </feature>
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            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="306" mass="32029" checksum="A3884B1FA9E278B3" modified="2019-02-13" version="1">MMETKLWIALCALLAIYLGSAVHADEHTPTPSSKTTPSTVQTTGTPVLDHESSLSPDAANHSGSSPATNTSSNGTVNVSSSTTTENTRITIIAEPGKDNVTDHTIKTTLAKNENITNTTLSPSQSSPTTAVPINIGTTHVLHTSAGAPVTPTPSLNQNASHHETKAPPATSAPASEPTKPESITNATTTKSNTNSSTASVQKASTSQPTSNTSQSNRQSTQPSIQTSSHTNNPSELNVDGDGTAHNSPGLDPLLAGLVSAFIIAAIIITLLLFLKLRRRGNGPEFRRLQDLPMDDMEDTPLSMYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVC5</accession>
    <name>A0A3P9CVC5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphatidylinositol-4,5-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="4 11">3.1.3.78</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25674"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57795"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Late endosome membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 11">Lysosome membrane</location>
            <topology evidence="3 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.78" evidence="4 11"/>
    <dbReference type="RefSeq" id="XP_004575591.1">
        <property type="nucleotide sequence ID" value="XM_004575534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVC5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026293"/>
    <dbReference type="Ensembl" id="ENSMZET00005027139.1">
        <property type="protein sequence ID" value="ENSMZEP00005026293.1"/>
        <property type="gene ID" value="ENSMZEG00005019603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466447"/>
    <dbReference type="KEGG" id="mze:101466447"/>
    <dbReference type="GeneTree" id="ENSGT00390000003680"/>
    <dbReference type="OrthoDB" id="9939933at2759"/>
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        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019178">
        <property type="entry name" value="PtdIns-P2-Ptase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21014">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21014:SF2">
        <property type="entry name" value="TYPE 1 PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tmemb_55A"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0967">Endosome</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="48"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001261"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012936"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365008"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="251" mass="27504" checksum="41A3A5433A2B070E" modified="2019-02-13" version="1">MADGERSPLLPDQHDGTNGFSPGFAPFPSSVAPGEPPPPYSPQGSPDSSSAPVISCRVCQTSISVEGKTHQHVVKCNICNEATPIKNAPVGKKYVRCPCNCLLICKVTSQKIACPRPYCKRIINLGPVHIGGDSPEPRRQPVGIRVICGHCSNTFLWTEFSARTLARCPHCRKVSSIGWRYPRRRSLLCFLLFLILAVSTAGLLVGTWKPAKSSKGIYVSWVLLLLLTLFTMARTIYWKCLKISEPLSNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CWY2</accession>
    <name>A0A3P9CWY2_9CICH</name>
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        <recommendedName>
            <fullName evidence="7">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CWY2"/>
    <dbReference type="Ensembl" id="ENSMZET00005027451.1">
        <property type="protein sequence ID" value="ENSMZEP00005026594.1"/>
        <property type="gene ID" value="ENSMZEG00005019834.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDCP1"/>
    </dbReference>
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        <property type="entry name" value="CDCP1_CUB_3rd_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056268">
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    </dbReference>
    <dbReference type="InterPro" id="IPR056269">
        <property type="entry name" value="CUB_CDCP1_2nd_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14477">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14477:SF1">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23665">
        <property type="entry name" value="CDCP1_CUB_6"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34623" checksum="BBB3FD99643E70FA" modified="2019-02-13" version="1">MFIPLLTITLCLLPGAQKLTLTAEPGATINIRNNNKVKGCQVCTRSIIKKCSIESLNSFSGSTVSVALECSRPQDVFSIEIVRHISKCLSTDVLRFNRTFTWNLAAAAPKAFQIDFTNTGLKQINPSEKCPDRHTYTLQAFQSTGNVAVGKYCRSGTISSAQVLKMSFNNFCFNFNLFGLLCVCVIALARISLTLPKGTSSSELLSPDYPESFPDDDTMEWYFQVPDKHGVDLQFLNLTQPDCVKKEVAVEYHQKGRVTSVLGLNDTQPLQNQGDFLLTLRNCEMERAPADSPGLTFTLKVSAYPPRSKGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYC3</accession>
    <name>A0A3P9CYC3_9CICH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CYC3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026997"/>
    <dbReference type="Ensembl" id="ENSMZET00005027862.1">
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        <property type="gene ID" value="ENSMZEG00005020140.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155908"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="231" mass="25554" checksum="D4D442CBF98425E9" modified="2019-02-13" version="1">MMSSSLLENPVQAILYLRELTTIVQNQQSLIQTQRARIEELDRRVDELIGENRHLRDVRIQQQHPYHHHHHHHHPDPSCLHHHHHHPQDPPLKTSPGSLPDAASPAQVEAAPAVQSSPTQPMDPGDMQLVPAEPSTISPVESESENGGSCHSCRSLVPMTPTTLCRSLALARKSESETVLHQFCCPAPEHPETETTSSSSGQMLSLEDGTSSGDRQETEGTKREGPSEYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZ43</accession>
    <name>A0A3P9CZ43_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZ43"/>
    <dbReference type="Ensembl" id="ENSMZET00005028123.1">
        <property type="protein sequence ID" value="ENSMZEP00005027252.1"/>
        <property type="gene ID" value="ENSMZEG00005020326.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111912"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025307">
        <property type="entry name" value="FIIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051249">
        <property type="entry name" value="NLRP_Inflammasome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985:SF2">
        <property type="entry name" value="APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13553">
        <property type="entry name" value="FIIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23679">
        <property type="entry name" value="UPA-FIIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51830">
        <property type="entry name" value="FIIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIIND" evidence="7">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CARD" evidence="6">
        <location>
            <begin position="283"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42696" checksum="1574C27A51776ACB" modified="2019-02-13" version="1">ASVSDGSSTFNRFIFYRFRCPGPGVFQCTLTRLVFVMAQEAELLYWNVQWDESLLQQAGKTAAGPLFNITCSEDAVRQLHLPHCETKEALCVDGLLSVAHVFDDGISILKPMRITDTHVIVNVSHLSAFGLIWNFVKKSFKIPEAGQVLLFLRFKDTVPLKINVFLLHERIHLSEVSIEHSGNDATYIETSSDCVLHIGQRYSVHCEPKGLKIQPNILVGFQHAEFWKKLGPNYYPTFEVFLTANLEVVTLIVKDQDGNEAWRRDGKSSTAAAEMTDKLLLIRSEFIERVSAEGLNKIVDKLLERHIIIDVEMESGTCETKSRANKVRCIIDTVRRKGNDACRHLLDVLKEVDPTLFRVIVPNEAKKTSKEAHELWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZ48</accession>
    <name>A0A3P9CZ48_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the sodium channel (TC 1.A.1.10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005027369"/>
    <dbReference type="Ensembl" id="ENSMZET00005028242.1">
        <property type="protein sequence ID" value="ENSMZEP00005027369.1"/>
        <property type="gene ID" value="ENSMZEG00005020400.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167873"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13433">
        <property type="entry name" value="Na_channel_gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000068">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000117">
        <property type="entry name" value="Voltage-gated Ca2+ channel, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001696">
        <property type="entry name" value="Na_channel_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044564">
        <property type="entry name" value="Na_chnl_inactivation_gate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF223">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00170">
        <property type="entry name" value="NACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="365"/>
            <end position="390"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="504"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="545"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="574"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="820"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="850"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="924"/>
            <end position="953"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1010"/>
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            <begin position="1052"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1122"/>
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        <location>
            <begin position="1163"/>
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        <location>
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        <location>
            <begin position="1357"/>
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        <location>
            <begin position="1391"/>
            <end position="1426"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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        <source>
            <dbReference type="RuleBase" id="RU361132"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027369.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1651" mass="190539" checksum="34260A179FB16FBD" modified="2019-02-13" version="1">MASLLPPVGMEVFRCFTAVSKEVVQQRHEAEVKERKAQVRKPDQTCSSPGDWEVPPFHLWCPPPQLLCTPLEDLDPFYQSQKTFMVLSKGNIINRFSADSSCYLLSPFNPLRTIFSLNSHTFFSIFILLAILGFGVLEFKFPVVKYVYMAIFVFEALVKVVARGFCVGRFTFLRDPWNWLDIIIISTLLVSQFVDLGKFAVLMTISLLLKIFTCTGAVFTGLKKTVEALVQSVKRLGCVIILTLFCLSILAMIGLQLFMGTLKNKCVIWSMNTNTTEFDFHIHTTSPENYYYIPGHPDPLVCGNRSDTECCPDGFTCVKAGSNPNFGYTSYDSFFWSLMSLFRLMMHDFWEGLMQLTLRTAGKSYLIVFLFVFFPGCFFLLSLILAVVVMTRAEQEETRDAEAIQREEEFGRIVEVLKRREEEEVSKDSLLPQELGGYAIAPLTIQQAGEGNRNRRMSLSTQFKLCVAEAEEHHRPLCCTCTDAFLKGDCCGCWRWLKQQFHTFITNPFFDLVIIICIIVSTIFTAMEHYPMMEEFMETLVIAELVFRVIFAAEMIIKLVALGLHGYFQVRWHIFDFILVIISLVQLGLADVEGLSLLHSFLPFRVFRLARWWPMLHMFLKIVWASVGNLTLVLFITVFMFSVAGVQLFQSDYKANVCRISHDRQLPRWHMEDFFHTFMLVFRVLCGHCLESLWDCMEVSNDGMCVTFFMIVLIVGKLLVNNKEEYLALSSVSSDQLTLDDNHTNMAAWEAPVAVAEIEFRTPENAEEKETQHVKQILLFLILEQNFMLKVNTDGTGRVWSNFRRACLCIVQHKFFEGSIVFIILLSCAALVFEDIYLGHRPVLQRVLKMADLVFTFVFLVEMLLKWIAFGFKKYFTSFWCWLDFLILDVSLFSLMGNMLGYTSRPLRALRTLRVPSRFKGMRVVLKVLAVTLPSMFSMLLVILVIWLVFSVIGVNLFAGKFSYCYNETSEELFSFYVVNNMAECFSLMDQNFSEVNWKTWTFNFDNVGMGFLSLLIMVSGTSSGWMDIMYAAVDSRQVEDQPRYEINVYMYLYFICFIIIGCFFTLNLFIRVIIDTIHQQRHKIGKHVFVTDQQQKYLSTIKKRFSEKRNKTVPRPQNCCLAWLFDLVTALYFEIFMVVVIFFNMVVLMVETDDQSEEKSLVLNWIHLILVAIFLVEFILKIIALRQHYFRNVLHIVDFVVLTLSIIGLFLADILEKYFVSPSLFSVMRLGRLFTLCGAFPHIRFARRIWMLIMGFVMSLPALFNIGLLFFLIVYTFSIIGMFNFAYVKHEMMIDDMFNFKTFGNSIISMTMITTSSGWDGLLSPIMNTPPDCDLRLPEPGNCANPTVGIVFFSSYILLFCLLVIHLFIVVILELFNTASPEDAEMLSDDHLQMFYETWRRFDPSGSQVIQYSELADFCDGLQDPLRIPKPNTIKLTHLNLPLFPGDQISCLDVLRTITTQVRSPGTGCQHFDMFLKLCLRESCWNYGNQKFLPPPFLPGVSVPASLCFISKLPQSTRHRRRWGRRSSRLVRLKAAFLRPGNDQYFEAARSDYVKHWTSPTMIYPCMVPVAGITTMIPRLRPPRHRRRGINFQNLRTLQRAPISITKPSTSLRSSLANVRSLDNKTFILKDFFTHSDLDLTILWIWITNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D5V7</accession>
    <name>A0A3P9D5V7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_004570062.2">
        <property type="nucleotide sequence ID" value="XM_004570005.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D5V7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029481"/>
    <dbReference type="Ensembl" id="ENSMZET00005030409.1">
        <property type="protein sequence ID" value="ENSMZEP00005029481.1"/>
        <property type="gene ID" value="ENSMZEG00005021992.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101469449"/>
    <dbReference type="GeneTree" id="ENSGT00940000157877"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000770">
        <property type="entry name" value="SRSF protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF24">
        <property type="entry name" value="SRSF PROTEIN KINASE 3-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="77"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="424" mass="47530" checksum="4103F24B4EEE4A37" modified="2019-02-13" version="1">MYWRHLLNRTMQRSPCLPHTEAEQHRVSEGGVSNSFKALGCQEQLDPKDSQVSEDPQEYCYGGYHPIQIGDTFNRRYQVVSKLGWGYFSTVWLCQDLKLGRRVAVKVLKSGAGFTQAGEDELALLRCASGSVGRHPFGQRIVRLLDEFKLVGVNGVHICLVLELLGPDLRCLQLCFGNPGLLQPWIKQILIQVLQGLDYLHSQCKIIHADIKPENILVCLEEQSHKAPAGGSSSSSLQTGKEASSPESNRVNPYSLKEIAVKIADLGSSCWVYKHFCEEIQTRQYRSLEVLLGSEYGPPADIWSVACMAFELITGDSLFEPRASESISLEEDHIGQITELLGKIPAAVALSGKYSAEYFSCRGDLRRVGLLRFWSLYEVLVEKYHFLLEEASGFSDFLLSMLNYHPEKRATAAQCLRHPWLTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7D3</accession>
    <name>A0A3P9D7D3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7D3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030087"/>
    <dbReference type="Ensembl" id="ENSMZET00005031034.1">
        <property type="protein sequence ID" value="ENSMZEP00005030087.1"/>
        <property type="gene ID" value="ENSMZEG00005022434.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159367"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008378">
        <property type="term" value="F:galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF32">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="45"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="193" mass="22376" checksum="AF5C4B679A4816AB" modified="2019-02-13" version="1">IFFSVKSLLSQTFGLLLLLTSLGFVFRDQLLKLVCVLMSNSPLCVLQLGEDTFNRAKLLNVGYTEALKDAEYDCFIFSDVDLIPMDDRNLYHCYDQPRHFAIAMDKFGFRLPYAGYFGGVSGLSKKQFLKINGFPNEYWGWGGEDDDIYNRYVITLNGMKVSRPDVRIGRYRMIKHERDKHNEPNPQRYCIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7M1</accession>
    <name>A0A3P9D7M1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7M1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030172"/>
    <dbReference type="Ensembl" id="ENSMZET00005031121.1">
        <property type="protein sequence ID" value="ENSMZEP00005030172.1"/>
        <property type="gene ID" value="ENSMZEG00005022491.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271828"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000943">
        <property type="entry name" value="Classical MHC class I molecule, alpha-chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF237">
        <property type="entry name" value="MHC CLASS I ANTIGEN TRANSCRIPT VARIANT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="181"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="344" mass="39349" checksum="C0345E1B264DF04E" modified="2019-02-13" version="1">SSSAGPAGYFFTLPLSMKHSLKYFVTGSSGVPNIPEFMGVLVFNGIQAGYCDSNNMTLKPKQDWAKKILQTSPEQKEWYDHMCFKKQPNFFKNMISHLKQFTKSEGVHVLQRIGGCERDENTGELTGLVHFGYNGEDFLEFNLETLTWIALKPEADIIKQEWDADRVRTKHNENFLTQICPEWLKTYVDSAKMSLVQKTPSSPVSCHATGFYPDRAVMFWRKDGEELHDGVDPGEILPNNDETFQMSVDLNVSSFTPEEWSRYDCAFQLSDGEDNIITSLNKTVIRTNWVENITKGEGKSFDLFCLLGLWILVIVVFELLTVCIVTFHWITCVCRLTILHQMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8I7</accession>
    <name>A0A3P9D8I7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8I7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030684"/>
    <dbReference type="Ensembl" id="ENSMZET00005031649.1">
        <property type="protein sequence ID" value="ENSMZEP00005030684.1"/>
        <property type="gene ID" value="ENSMZEG00005022842.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182984"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000037">
        <property type="entry name" value="Serine/threonine-protein kinase tousled-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF20">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOUSLED-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="405"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="715" mass="82256" checksum="28624B0BCAD7DAD0" modified="2019-02-13" version="1">MMEELHSLDPRRQELLEARFTGVGVAKVCQNQNESSNQSLCSVGSLSDKELETPEKKANDQRVRKRKADHFDSQAKAGARGHKISDYFERPCISPSKMNCLIHLSFFLSSKTLDLPILSHMLLVYSQIAVSINVLVPDCYHVQQGSPSSVSSNTEHSSCSLKPPSLHVLHKATQSDLTIEKLTAMENNKNSDLEKKEGRIDDLLRANCDLRRQIDEQQRMLERYKERLNKCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKLLAKRKPPSMAQTPPPSLEQNKRKSKANGAESEALSQAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEGRSIIMQIVNALKYLNEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLVYRKEDRIDVHQLASDPFLMPHIRKSVASSGTSGMAMASTSSSSNSSASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D970</accession>
    <name>A0A3P9D970_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable G-protein coupled receptor 25</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D970"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030657"/>
    <dbReference type="Ensembl" id="ENSMZET00005031622.1">
        <property type="protein sequence ID" value="ENSMZEP00005030657.1"/>
        <property type="gene ID" value="ENSMZEG00005022835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278303"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000248">
        <property type="entry name" value="ATII_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF954">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00241">
        <property type="entry name" value="ANGIOTENSINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="29"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="341" mass="38561" checksum="3D05CA734616DC9F" modified="2019-02-13" version="1">MVRLTTLPQYNEYFLPTIYFLIFFTGFVGNLLVILVVGNKKRGGRLVDTFVVNLALADLVFVLTLPLWAISAMKKNYWNFGQFSNFLCKMSSYMIAVNRFSNIFFLTCMSVDRYLAVVKLMDSRYLRSSLCIRATCLAVWASSLVLGIPSLVYRKVEKDGNFCTEDRSSPFFLGISLVMALLTFIFPVFIIMLCYGTIIMHLNKHCAAAGNPRAEARRKHSLKMVLCIIVAFVVSWLPYNVFKSITVILRLADVETSCEVNSQLKNGLIISCCLAFLNSCVNPAIYFFLDHHFRRRAEMMYKTCLGKSKMLQSFNSSASFTNGYTSESNGTTGGRSQTQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9G0</accession>
    <name>A0A3P9D9G0_9CICH</name>
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        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9G0"/>
    <dbReference type="Ensembl" id="ENSMZET00005031987.1">
        <property type="protein sequence ID" value="ENSMZEP00005030989.1"/>
        <property type="gene ID" value="ENSMZEG00005023101.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234557"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_V-set"/>
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    <dbReference type="InterPro" id="IPR051287">
        <property type="entry name" value="TCR_variable_region"/>
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        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 16"/>
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    <dbReference type="PANTHER" id="PTHR19367">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION"/>
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            <begin position="23"/>
            <end position="131"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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            <dbReference type="ARBA" id="ARBA00023130"/>
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            <dbReference type="ARBA" id="ARBA00023319"/>
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            <dbReference type="Ensembl" id="ENSMZEP00005030989.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="146" mass="16193" checksum="0516EC07D061B22D" modified="2019-02-13" version="1">MIVASPIEKMISNLLNKCRAQKDNVLQAKGEETAAAGGTVTLGCLYNVSITTNNYLFWYKQDGNNSPKFILSRVSGDQGNTAAEFKERFSSTLDSSIRSAPLKIQKLQLSDSAVYYCALQPTVTGNSKTLYKNLWSKDNRILHNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAN7</accession>
    <name>A0A3P9DAN7_9CICH</name>
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            <fullName evidence="7">SAM domain, SH3 domain and nuclear localisation signals 1b</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
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            <taxon>Cichlomorphae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAN7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031424"/>
    <dbReference type="Ensembl" id="ENSMZET00005032443.1">
        <property type="protein sequence ID" value="ENSMZEP00005031424.1"/>
        <property type="gene ID" value="ENSMZEG00005023423.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="CDD" id="cd11822">
        <property type="entry name" value="SH3_SASH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
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        <property type="entry name" value="SAM"/>
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    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
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        <property type="entry name" value="SPIDER"/>
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    <dbReference type="PANTHER" id="PTHR12301:SF4">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN SAMSN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12485">
        <property type="entry name" value="SPIDER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="225"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="353" mass="40175" checksum="5F7B0F92DBB938E3" modified="2019-02-13" version="1">MIRSITDLHLYQNTLTRFERFEALRQHSPLMKPQDNESCLRTREQNGELTTSRVRRTELEHLSQSDRKHIEASPEGTQTIISSRDMQKGEAEKTDADHGRPITKAHHRSSISLESLYSLNSRQSSSSGVTSGSDYSSNRNSLKLEDDLLCTRQFCGRARVHTEYVPSPYDTESLKLKVGDVIDIITKPSMGIWTGMLNGRIGNFKFIYVDILRKENLETQIHRVRHKSTVQEVLKRLSLEEYYTCLQLGGYQTVDDLMRLRENHLMELNVTDPEHRQRLLAAVNSLQQLRSDCQLENEADQKAESSTENMKADVSNCPRDSGCPMPSDSPDSITEEADLHFLSDHALPANVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DB39</accession>
    <name>A0A3P9DB39_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger HIT domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with NUFIP1. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004557495.1">
        <property type="nucleotide sequence ID" value="XM_004557438.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DB39"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031910"/>
    <dbReference type="Ensembl" id="ENSMZET00005032944.1">
        <property type="protein sequence ID" value="ENSMZEP00005031910.1"/>
        <property type="gene ID" value="ENSMZEG00005023807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476546"/>
    <dbReference type="KEGG" id="mze:101476546"/>
    <dbReference type="CTD" id="9326"/>
    <dbReference type="GeneTree" id="ENSGT00390000010822"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048371">
        <property type="entry name" value="ZNHIT3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21373">
        <property type="entry name" value="ZNHIT3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="12">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="145" mass="16393" checksum="AD8B48300C837147" modified="2019-02-13" version="1">MQLCSVCSERTPKYRCPACKIRYCSLGCYKKHKDTCLPVDKPAPSNPETKTAVSTESWSVDDLLHEDDITDKVPLQRLQMLGQSKELKDLLCNPHLRQLLCSIDGAEHKEDAMKSAMQEPLFMEFSDQCLKIVENDAKSSEDANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCT7</accession>
    <name>A0A3P9DCT7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Relaxin-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a B chain and an A chain linked by two disulfide bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024656880.1">
        <property type="nucleotide sequence ID" value="XM_024801112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCT7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032174"/>
    <dbReference type="Ensembl" id="ENSMZET00005033213.1">
        <property type="protein sequence ID" value="ENSMZEP00005032174.1"/>
        <property type="gene ID" value="ENSMZEG00005023964.1"/>
    </dbReference>
    <dbReference type="GeneID" id="112432602"/>
    <dbReference type="KEGG" id="mze:112432602"/>
    <dbReference type="GeneTree" id="ENSGT00940000154396"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04365">
        <property type="entry name" value="IlGF_relaxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051777">
        <property type="entry name" value="Insulin-like_neuro_ligands"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20968">
        <property type="entry name" value="ILGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20968:SF0">
        <property type="entry name" value="RELAXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0372">Hormone</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018121529" description="Relaxin-3" evidence="11">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="12">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="147" mass="16176" checksum="A89F0848E141AD5C" modified="2019-02-13" version="1">MWKAVVLAVCLLVAGVQPMDDPAYGVKLCGREFIRAVIFTCGGSRWRRSLRSLDASEDPFTSPQDELSEGLNHNFAVESLLQRNTDPSSASRDNQEGAFSRSTRSFITEEILEALRKADRKGRDVVVGLSNACCKWGCSKSEISSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCU9</accession>
    <name>A0A3P9DCU9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Essential MCU regulator, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Single-pass membrane protein with aspartate-rich tail 1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SMDT1/EMRE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567940.1">
        <property type="nucleotide sequence ID" value="XM_004567883.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCU9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031982"/>
    <dbReference type="Ensembl" id="ENSMZET00005033016.1">
        <property type="protein sequence ID" value="ENSMZEP00005031982.1"/>
        <property type="gene ID" value="ENSMZEG00005023853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478003"/>
    <dbReference type="KEGG" id="mze:101478003"/>
    <dbReference type="CTD" id="100000862"/>
    <dbReference type="GeneTree" id="ENSGT00390000017489"/>
    <dbReference type="OrthoDB" id="10039145at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018782">
        <property type="entry name" value="MCU_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33904:SF1">
        <property type="entry name" value="ESSENTIAL MCU REGULATOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10161">
        <property type="entry name" value="DDDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="99" mass="10940" checksum="6C5F976E831990CC" modified="2019-02-13" version="1">MAASMLRLPLRLSSRNMGIMTRNTGLKTSHIPRTTQSRTAVSTPSGAILPKPEKTPFGLIRMTLVVVPFLYVGNLISKNFAALLEEHDIFVPEDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDD6</accession>
    <name>A0A3P9DDD6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Synaptojanin-1</fullName>
            <ecNumber evidence="5">3.1.3.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.36"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with ASH/GRB2. Interacts with PACSIN1, PACSIN2 and PACSIN3. Interacts with AMPH, SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain). Interacts with BIN1 and DNM1. Interacts with EPS15.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="5"/>
    <dbReference type="RefSeq" id="XP_024659655.1">
        <property type="nucleotide sequence ID" value="XM_024803887.1"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005032700"/>
    <dbReference type="Ensembl" id="ENSMZET00005033759.1">
        <property type="protein sequence ID" value="ENSMZEP00005032700.1"/>
        <property type="gene ID" value="ENSMZEG00005024358.1"/>
    </dbReference>
    <dbReference type="CTD" id="8867"/>
    <dbReference type="GeneTree" id="ENSGT00940000157964"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000076">
        <property type="entry name" value="Synaptojanin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000003">
        <property type="entry name" value="Synaptojanin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015047">
        <property type="entry name" value="SYNJ1/2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08952">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01165">
        <property type="entry name" value="DUF1866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAC" evidence="18">
        <location>
            <begin position="119"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1034"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1565"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1609"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1046"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1102"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1157"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1206"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1228"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1265"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1335"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1389"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1418"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1437"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1571"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1647" mass="178926" checksum="C36036662671C51F" modified="2019-02-13" version="1">MAFSKGYRIYHKLDPPPYSVIVETRAREECLMFESAAVAVLSAAEKDAIKNTYTKIVDAYGILGVLRLNLGDSMLHSLVVVTGCSSVGKVQDSEVFRVTQTDFISLKNDPGDEERIAEVRKVLNSGHFYFAWSSTGVSMDLSLNAHRRIIEDTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAGHKQAKACIFSRLSSERAGTRFNVRGTNDDGQVANFVETEQVIFLDDKVSSFIQIRGSISLFWEQPGIQVGSHRVKLSRGFEANAPAFERHFTALRRLYGKQVIINLLGSKEGEHMLSKAFQSHLKASEHASAVKMVNFDYHQNVKGGKADKLHSVLKPQLNKFIEECGFFYYSGETGILRTQGGTMRTNCLDCLDRTNSVQAFFALEMLPKQLEQMGLTEKPQLVARFQEVFRTMWSANGDSVSKIYAGTGALDGKAKAGKLKDGARSVTRTIQNNFFDSSKQEAIDILRLGSTLNSDLADKARALLTTSSLYVTEPVLQSASPRVLLGMCQNYHKYTRPKQIRVCIGTWNVNGGKQFRSIAFRNQTLNDWLLDAPKNAGHPEFQDSRTNPIDIFAIGFEEMVELNAGNIVSASTTNQKLWAAELQKNISRDHKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGGVAIRLLFHTTSICFVCSHFAAGQSQVKERNDDYNEITRRLSFPMGRLLYSHDYVFWCGDFNYRISLPNEEVKDLIKQQNWDALTAGDQLLDQKNAGLVFRGFIEGKLDFAPTYKYDLFSEDYDTSEKCRTPAWTDRILWKRRKWNFDKTAQEMNIVAAASSSRDSDDDVEQTWSPGTLKYYGRAELKTSDHRPVVAVIDVDILEVDPEARHQVYKDVIARQGPPDGTILVSLCSSGPDDYFDDALIDELLEKFANFGEVILIRFVEEKMWVTFLEGYSALAALSLSASTVLGKVIDIRLKSPGWIKSLEEEMSVERICGSIPTSASSTLLAEDTDVGDDDYDMEGDVDEEVEEILPQHLQPGAGTGPGSSPLPSPRSSPCPSPTHGEPAAPSRPSRGAQPSRPSQGPPVDFQPGAPTAQGLEPKRPPPPRPNAPPARPAPPQRPPPPSGRGQTAAGAPGPGGASRPNIPPRAGVISVTPQSRPPPPSHPGAPRPIPEVHPGAPHPISDTHPGAPRPVPSAQTKPADLPLGPQPSGAPPAAPPAVKPQVSSPMQPPMQPQPAAPPAQSQLPPPMQPTLPAPLQPQPAPAPKAAGPSAAPAAATPAGPQPSLASPKPPPRSRSSHALPPDAAKSETAPAAQTNGLNGIQGEAQWKPDPFDTLTSDFLPSSSSWHTTQSLTRGSSRRTPTVFSSTTLPSSFSHQSSTLADLQAFDSSSSSSLSTPSPFASTLLPPPPVPSRSRSQETLRASPNPFSADPLPARPSSTNPFTGPLVQQQQRRPLTPDFTFQLSPPTANLQRTVSLTPPLIPTPAQTGAPAAVPTTQLQKTMSLFGPSSSLNPAPASLLPLALNPSPPPTLPMVAPSSLPPAVAPRHQPPGPVAKQAKQWVTFDDDFQPPSKTSQNPVFPSSSLVPQTQMQPSSSVFNLEPEWLSSMPAAIPTLSPPIPNRTATSNPKLPEGPTDNGLFPRDSMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDU9</accession>
    <name>A0A3P9DDU9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Si:ch211-284o19.8</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DDU9"/>
    <dbReference type="Ensembl" id="ENSMZET00005033593.1">
        <property type="protein sequence ID" value="ENSMZEP00005032539.1"/>
        <property type="gene ID" value="ENSMZEG00005024240.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244890"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF94">
        <property type="entry name" value="PROTEIN LIFEGUARD 1 ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="315" mass="35103" checksum="6811F9EFD15C9226" modified="2019-02-13" version="1">KMKAEQSVASDHMIREADCWSKDSANLLMSADSITSKETQHDPGSDVPSASMHSYQEEQPPAYSEAPPVYKPPQISRYESFHDINPQISSETTPLVSSSSFDDEIVRKGFIRKVCTIVTLQLLFTFTVVCVFTFSSVVKEAVQSNIWVYLSSFIVFVVVAIALSCCKSFSQHHPWNIVALFVVTVSMSYMTGTIASFHNTTAVILAMGVTLAISISIIAFSAQTRYDFTYCNSALLILVVDVAMFGIFCTFYYSYIAEVIYGCLGALLFSLYLVIDCQLVMGRMAYSADPEDYINAALRIYLDVVLIFLYILGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEZ9</accession>
    <name>A0A3P9DEZ9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actinin alpha 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012771131.1">
        <property type="nucleotide sequence ID" value="XM_012915677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DEZ9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033058"/>
    <dbReference type="Ensembl" id="ENSMZET00005034153.1">
        <property type="protein sequence ID" value="ENSMZEP00005033058.1"/>
        <property type="gene ID" value="ENSMZEG00005024648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467576"/>
    <dbReference type="GeneTree" id="ENSGT00940000159343"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000005">
        <property type="entry name" value="Actinin alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000002">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000003">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="151"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="805"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="437"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="910" mass="104169" checksum="F0FD4977313141EA" modified="2019-02-13" version="1">MVDYHAANNQSTVGGAQTYMEQENDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPDLIDYDSLRKDDPVTNLNNAFEVAEKHLDIPKMLDAEDIVGTLRPDEKAIMTYVSCFYHAFSGAQKAETAANRICKVLAVNQENEQMMEDYEKLASDLLEWIRRTIPWLENRTQEKTVNDMQVKQEDFRDYRCVHKPPKVQEKCQLEISFNTLQTKLRLSNRPAFMPSEGRMVSDINKAWHNLEGAEKGYEEWILSEIRRLERLEHLAVKFHQKCAIHESWTDGKEAMLTQKDYETCTLSEVKALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDAASVNARCQKICDQWDVLGALTHKRKESLERTEKQLESIDELYLEYAKRAAPFNNWMEGAMEDLQDMFIVHNIEEIQGLITAHEQFKSTLPEANKEREAIQSIQSEVQKIAQSNGIKLSSGNPYTSITPESINSKWEQAMAMVPLRDNALQEELNKQNSNDTLRATFATQANTVGAYIQAKMEEIGRISIEMNGTLEDQLTNLKEYQKSIISYTPEINKLEGYHQHIQEALIFDNQYTSYTMEHLRVGWEQLLTTIARTINEVENQILTRDAKGISQEQLYEYRASFNHFDKTLNGGERGARHDHSGALMAEEFKACLISLGYDVEKDKQGEAEFNRIMGIVDPNGSGAVTFQAFIDFMSTETTDRDTADQVIASFKILAADKNYITADELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHA3</accession>
    <name>A0A3P9DHA3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease A-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the pancreatic ribonuclease family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHA3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033818"/>
    <dbReference type="Ensembl" id="ENSMZET00005035009.1">
        <property type="protein sequence ID" value="ENSMZEP00005033818.1"/>
        <property type="gene ID" value="ENSMZEG00005025290.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287062"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.130.10">
        <property type="entry name" value="Ribonuclease A-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001427">
        <property type="entry name" value="RNaseA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036816">
        <property type="entry name" value="RNaseA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023411">
        <property type="entry name" value="RNaseA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023412">
        <property type="entry name" value="RNaseA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437:SF10">
        <property type="entry name" value="ANGIOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00074">
        <property type="entry name" value="RnaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00092">
        <property type="entry name" value="RNAse_Pc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54076">
        <property type="entry name" value="RNase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00127">
        <property type="entry name" value="RNASE_PANCREATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017854393" description="Ribonuclease A-domain domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease A-domain" evidence="9">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="142" mass="16523" checksum="7754EAFED912BA32" modified="2019-02-13" version="1">MRILFICLLLIASESSTLEETRYGQFRRQHINAKMTAMDCDTVIRRKQIYNVDNSCKDTNTFILDNPSEIKNICVEGKFDETLQMTKSHKMFKVVKCELKKEGARKPRCQYTGNLLTNRYVAVDFKCKGKLPVHYDLTFPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHL5</accession>
    <name>A0A3P9DHL5_9CICH</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHL5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034230"/>
    <dbReference type="Ensembl" id="ENSMZET00005035432.1">
        <property type="protein sequence ID" value="ENSMZEP00005034230.1"/>
        <property type="gene ID" value="ENSMZEG00005025587.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154986"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="109" mass="12597" checksum="6AEB59CD0D549A02" modified="2019-02-13" version="1">MPLSLSLFLRVVSGSRDTTLRVWDVSTGRCEHVLTGHLAAVRCVQYDGRRVVSGGYDYMVKVWDPETEVCLHTLQGHTNRVYSQLLPNTKQKICFLLRTFQKVQLLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJZ2</accession>
    <name>A0A3P9DJZ2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJZ2"/>
    <dbReference type="Ensembl" id="ENSMZET00005035930.1">
        <property type="protein sequence ID" value="ENSMZEP00005034694.1"/>
        <property type="gene ID" value="ENSMZEG00005025939.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244843"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000088">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF151">
        <property type="entry name" value="ICOS LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="88"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="270" mass="30488" checksum="6C9FEC2EBE90AB55" modified="2019-02-13" version="1">MTSEWTRPDLDPRFVFLWRAGQDLIYMKNPSYIGRSSLFTDELKHGNISLKLSKVKPADQGRYRCYIPEKDEEVFIDLVVASGAVSSPVISLANLDKAISGVVLQCESAGWYPEPELLWLDAEGNLLSAGPTETLRGPDDLYTVSSRVTVEKRHSNNITCRVQQRNTNQSREIHIHVPDEYFQLNSSSAAPIIIGVVVSLALSIILILIGVFFIWRRNKTNVRKPHCLRKKQETTKTEPDQEQETLMTQDIEPVSDMTETDKTTKPVGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK58</accession>
    <name>A0A3P9DK58_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor 19 (SC1), like</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Potential transcription factor that may play a role in the regulation of genes involved in cell cycle G1/S transition. May bind to regulatory elements of genes, including the promoter of the transcription factor FOXO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004572704.1">
        <property type="nucleotide sequence ID" value="XM_004572647.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DK58"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034758"/>
    <dbReference type="Ensembl" id="ENSMZET00005035995.1">
        <property type="protein sequence ID" value="ENSMZEP00005034758.1"/>
        <property type="gene ID" value="ENSMZEG00005025983.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487064"/>
    <dbReference type="KEGG" id="mze:101487064"/>
    <dbReference type="CTD" id="558431"/>
    <dbReference type="GeneTree" id="ENSGT00390000015391"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22685">
        <property type="entry name" value="FHA_TCF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15609">
        <property type="entry name" value="PHD_TCF19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042803">
        <property type="entry name" value="TCF19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039095">
        <property type="entry name" value="TCF19_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15464">
        <property type="entry name" value="TRANSCRIPTION FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15464:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="557" mass="61225" checksum="863430729DE71AA6" modified="2019-02-13" version="1">MLAGVQPCFQLLRIGSSAGESARDLYTFRPAQNHSVFRLGRAAELCDVTLDSPSVSRIHAELEAERETGEGVEAQEEEGWRVHIKDRSSHGTWVNEVRLQPGIQWELSDGDTLIFGGQTDPGNPEFYFLFQKVKVRPLDFDAITLPKAGTFSSDLQNRIRTSLDRKVAANLDLSKLSINRATVILNSIGSLSKMKGSAWTFKRSHSHEGTVSDPGTSTSPPLAVGFSSLLPHSTPPSFTSAASLPQTKALPQTSRSRRKSAHTVLLEDDSSDEPRSRGVLAGVVEDGQRARGKKRRRLYKSESEGFSSPPPPQLQPKTHSDIRRPLEAKPFPVGIRTIGSFHGAMTNSRLNEHLFQASFTSKQEAEKVNRVKTVVHGNIAAFRQQKPAHCSPTAARGRRRANSSPVFSPLVVGGENYNLASPSVRIRADERVSVQFNRFHHPTGKRRGRPRKHPLPPRPSLPSPSSSSSSSTSSASSSSSGSSSSSSDEDEDDEEEDDVMVGTVEPCAAPRCRLPQQDTVQWIQCDVCDAWYHIDCLHVDRKKLLMDPNADFHCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNP0</accession>
    <name>A0A3P9DNP0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNP0"/>
    <dbReference type="Ensembl" id="ENSMZET00005037336.1">
        <property type="protein sequence ID" value="ENSMZEP00005036064.1"/>
        <property type="gene ID" value="ENSMZEG00005026908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263473"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER K-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="169" mass="19634" checksum="6A654171AEC01128" modified="2019-02-13" version="1">MTERIIALSIIAYVWMCVLDQLKSLLWSLTAVGRKDLRNLSVPHRGWLTMTFVYIDNLMTWANAQTYCRLHYTDLASVRNMPENQKIDEVVPAGVKVWIGLFRDSWKWTNGSNSSLRYWTIIEPNNLMGHESCVAANFLLNAKWEDWTCDSMKEFVCYIGKPCFRKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DP16</accession>
    <name>A0A3P9DP16_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DP16"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035871"/>
    <dbReference type="Ensembl" id="ENSMZET00005037137.1">
        <property type="protein sequence ID" value="ENSMZEP00005035871.1"/>
        <property type="gene ID" value="ENSMZEG00005026785.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011863"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000011">
        <property type="entry name" value="B-cell receptor-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF15">
        <property type="entry name" value="B-CELL RECEPTOR-ASSOCIATED PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="15">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="16">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="132"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="265" mass="30236" checksum="F0CF2697DCA16FDD" modified="2019-02-13" version="1">MSLQWTAVATFLYAEVFLVLLLCIPFISPKRWNSIFKSRIIKAITLYGNTAFMVAIAILVFLLIDAFREVRKYSVTEKVDLANHPTAIEHIHMKLFRAQRNEYIAGFALLLCLLLRRLATLLSQQASLMASNEAFKKQAEGASNAAKKYMEDNEMLQEKLREAGLELPEAGKKGPGPQEENKTLKEEVKSLKEELEATKKALQKSDNDVRAMKKQSANLTVEYDRLLEEHSKLLVTHTHTHTHTHTHTHTHTHTHTHTKISKTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPV8</accession>
    <name>A0A3P9DPV8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="7">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="7"/>
    <dbReference type="RefSeq" id="XP_004545185.1">
        <property type="nucleotide sequence ID" value="XM_004545128.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DPV8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036171"/>
    <dbReference type="Ensembl" id="ENSMZET00005037445.1">
        <property type="protein sequence ID" value="ENSMZEP00005036171.1"/>
        <property type="gene ID" value="ENSMZEG00005026990.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487718"/>
    <dbReference type="KEGG" id="mze:101487718"/>
    <dbReference type="CTD" id="126789"/>
    <dbReference type="GeneTree" id="ENSGT00950000183160"/>
    <dbReference type="OrthoDB" id="271910at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000011">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000006">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="8">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="8">
        <location>
            <begin position="162"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="300" mass="34154" checksum="36AB2D01E5814E81" modified="2019-02-13" version="1">MHNRARYLIFFQYIGTKYRGAVKVPPHQLGKKGVQDHLEDAIQRLRPVNPVSLSVSSRTDTGVHALSNSAHFDLQRKNDKLPFTEDVLVQALNFHLGTEQIRITRAHRVPHDFHARFRAQSRTYVYRIALGISHHSLLPLTDWDLCWSLRNTELNVDAMHEAASLLLGTHDFSSFRAVNSDLPFKNPVKTMDVISIQQGNSFAYAHFHREIPSWELTFTSKSFLYKQVRRMTGAMVAVGQGLLSVPQLKKILEARDSLAYPQGMAAPAHGLFLTRVDYRDTDLQLSPQLSEELLTSTRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQK4</accession>
    <name>A0A3P9DQK4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox protein Hox-B1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004558972.1">
        <property type="nucleotide sequence ID" value="XM_004558915.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQK4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036411"/>
    <dbReference type="Ensembl" id="ENSMZET00005037690.1">
        <property type="protein sequence ID" value="ENSMZEP00005036411.1"/>
        <property type="gene ID" value="ENSMZEG00005027175.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476262"/>
    <dbReference type="KEGG" id="mze:101476262"/>
    <dbReference type="CTD" id="58046"/>
    <dbReference type="GeneTree" id="ENSGT00940000157315"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="205"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="295" mass="32663" checksum="39B809207E8594CA" modified="2019-02-13" version="1">MTSYQELTAEGENSPLLTGCCRAKEVINQDLGSRSHPELGGRDEEGKVEVEVASGFYSPRLTLCTSSDSPPPPGFEALEGFSTLACPHSSRVPWRCRVQGQGSPGRGYCASNKEKPQRFGSLTEEIQIYPHNIPEIHITVGSSTSPDCKGADTDERSKTFEWMRVKRSQHRAVRTRMTCGFSIVDSGLGVVEAGNRSICADGHPTMNGAPRISYSTKQLTELEKEFHFNKYLTRARRVEVAGALQLSETQVKVWFQNRRMKEKKLQRDGLLSDPRPAAPHSHADTLDTCPFHGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSM5</accession>
    <name>A0A3P9DSM5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">palmitoyl-CoA hydrolase</fullName>
            <ecNumber evidence="7">3.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:84099"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74410"/>
            <dbReference type="ChEBI" id="CHEBI:233601"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="7"/>
    <dbReference type="RefSeq" id="XP_004573627.1">
        <property type="nucleotide sequence ID" value="XM_004573570.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSM5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037242"/>
    <dbReference type="Ensembl" id="ENSMZET00005038545.1">
        <property type="protein sequence ID" value="ENSMZEP00005037242.1"/>
        <property type="gene ID" value="ENSMZEG00005027757.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472327"/>
    <dbReference type="KEGG" id="mze:101472327"/>
    <dbReference type="GeneTree" id="ENSGT00940000155779"/>
    <dbReference type="OrthoDB" id="155976at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098599">
        <property type="term" value="F:palmitoyl hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000037">
        <property type="entry name" value="Lysosomal thioesterase PPT2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF71">
        <property type="entry name" value="ZGC:66024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018083666" description="palmitoyl-CoA hydrolase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="296" mass="33788" checksum="75B3CC4E0306EFDE" modified="2019-02-13" version="1">MKCPRVAAGSRGPMLLLLLLVVAGVCVDSYKPVIIVHGIFDGPQQFQNLSRFIKKVHPGTEVTVIDLYDDLLSLQPLWKQVPDFRQSFNSIMKNAPDGVHLLCFSQGGLICRALLSTTPNHNVHTFISLSSPLAGQYGDTDYLQKVFHKTLKKNVHFICYNKFGQKVSICDYWNDPHQRLSYLRNNIFLPLLNGERPHSDMKAWRENFLQIEKLVLIGGPDDGVITPWQSSHFGFYDSSENVVEMQKQEFYLNDAFGLKTLDQRGDLVTCVHSGVKHTTWHSNFTVFRNCMEKWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTJ6</accession>
    <name>A0A3P9DTJ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTJ6"/>
    <dbReference type="Ensembl" id="ENSMZET00005038902.1">
        <property type="protein sequence ID" value="ENSMZEP00005037593.1"/>
        <property type="gene ID" value="ENSMZEG00005028039.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000174597"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785:SF2">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018139293" description="Sushi domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="7">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="204" mass="23379" checksum="844C912D738D427F" modified="2019-02-13" version="1">MRLFGLSCLFLLWLNPNESLQQNEVTCSHPQALYLDYWGDSGQQQRLGDSVSYTCGSDYRSTDGAPWATCTRDGWKPNPLCQGAQGCGRPPPLSDGDTKTSTKHLYQHNEKVEYICQRYYVMKGGPFKTCNHGEWTGEIRCLPCTVNRDDMNRHNIQFRFSRDDKLYTEHDDEIEFMCTRGRPVGTLGMRQKCEHGVVHLPTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARC4</accession>
    <name>A0A3P9ARC4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sedoheptulokinase</fullName>
            <ecNumber evidence="10">2.7.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbohydrate kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a modulator of macrophage activation through control of glucose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16802"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.14" evidence="10"/>
    <dbReference type="RefSeq" id="XP_014264094.1">
        <property type="nucleotide sequence ID" value="XM_014408608.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARC4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000256"/>
    <dbReference type="Ensembl" id="ENSMZET00005000312.1">
        <property type="protein sequence ID" value="ENSMZEP00005000256.1"/>
        <property type="gene ID" value="ENSMZEG00005000302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470627"/>
    <dbReference type="KEGG" id="mze:101470627"/>
    <dbReference type="CTD" id="23729"/>
    <dbReference type="GeneTree" id="ENSGT01000000214434"/>
    <dbReference type="OrthoDB" id="10264182at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="ASKHA_NBD_FGGY_SHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000111">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000132">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="459" mass="49538" checksum="6041B8A6CC431C59" modified="2019-02-13" version="1">MSNFILGLDVGTSSVKAVLLDRGCRAIAASQSLPTVSDLADDSGIKAKEQDTGRIIDTLDRCIGLLPRDKLQHVCCIGLTGQMHGVLFWKPKSGCVWSNSDSLTAKDTSQLITWQDGRCSNDFLTSLPRPDSHLSVATGFGCATIFWYMKHKPKFLEDFTVAGTIQDYVVSMLCGLDRCVMTPQNAASWGFFNTSSNQWNENILKGAGFPLHLLPKCVPSGSLAGKTCSQWHGIPAGTPVGAALGDFQCSVYSCMSERTDAVLNISTSAQLTYAMPADFKPPDSLQPASSISYFPYFESTYLAVAASLNGGNVLASFVEMLTSWMRELGAELSDSCLYEKLIHCALNQETSNLRVSPTILGERHDPLCLGHVTGISTSNLSLGHVIRALCHGVLDNVTSMMPVEHLQQAGVRRIVGSGSALARNEVLRQEVEKAFPLQVVYGQNADSALGVAMILCDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARX5</accession>
    <name>A0A3P9ARX5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tribbles pseudokinase 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547482.1">
        <property type="nucleotide sequence ID" value="XM_004547425.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARX5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000363"/>
    <dbReference type="Ensembl" id="ENSMZET00005000422.1">
        <property type="protein sequence ID" value="ENSMZEP00005000363.1"/>
        <property type="gene ID" value="ENSMZEG00005000378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479520"/>
    <dbReference type="KEGG" id="mze:101479520"/>
    <dbReference type="CTD" id="57761"/>
    <dbReference type="GeneTree" id="ENSGT00950000182986"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000153">
        <property type="entry name" value="Tribbles homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF14">
        <property type="entry name" value="TRIBBLES HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="353" mass="39960" checksum="8EB4C274043990E9" modified="2019-02-13" version="1">MSASVSTTRSQLCLKRLLDQPQVDSLKCKRARLAPPPTSTGISPCLRPTSPAPTSNSSQSSSRVGSYFLFERCEREETYRAVHVHTQQQYTCQVLPLRGYQERLAAYDRIGKHENICALQDVVIGQNKVYVFLPGHHGDMHAYVRNRKRLNEEEAGLLFAQMLNAVMHCHDHGVVLRDLKLRRFVFIDKYRTRLALLGLDDCVLLHGNNDDDSLTDRHGCPAYVGPELLTNGNGSYSGRAADIWSLGVSLYTMLIGRYPFQDTQPAALFAKIRRGAFSLPDWMSPEAKCLIGCMLRKSPTERLTASELPMHPWLTKPRMPHSNMHKIHHSSHTTLQNKQEDNDQVVPIWTETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AS36</accession>
    <name>A0A3P9AS36_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561561.1">
        <property type="nucleotide sequence ID" value="XM_004561504.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AS36"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000530"/>
    <dbReference type="Ensembl" id="ENSMZET00005000595.1">
        <property type="protein sequence ID" value="ENSMZEP00005000530.1"/>
        <property type="gene ID" value="ENSMZEG00005000498.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476464"/>
    <dbReference type="KEGG" id="mze:101476464"/>
    <dbReference type="GeneTree" id="ENSGT01100000263525"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="10">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="68" mass="7424" checksum="18611F6143673F4C" modified="2019-02-13" version="1">MSGSTNVVAMKKVVQQLRLEAGINRVKVSQAAADLQQFCLQNAQQDPLLTGMSSSNNPFRPQKVCSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASA6</accession>
    <name>A0A3P9ASA6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein SSUH2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASA6"/>
    <dbReference type="Ensembl" id="ENSMZET00005000333.1">
        <property type="protein sequence ID" value="ENSMZEP00005000277.1"/>
        <property type="gene ID" value="ENSMZEG00005000314.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163873"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="380" mass="42800" checksum="7D035FACB356D392" modified="2019-02-13" version="1">MRFWMTLTVTDSVRLISAWLICSRMNSSAMYPPVMAPQANMFVNVPGYEGTVPGGAGFLPPPMPMEPVAPPQPSPENPEWSIPSLSEDEAREAFKKFVSSHICYSEDPVTQGVITSMEPFNTFRYRLETFTESRSTDWAHKPHEGEPADFYTQPAPRPWEVQATHPKHFSDHTEKIRVPYTSSIKECHTCHAAGTEQCKECSGSGKKACPMCNGAAKSDPACTHCNGTGKDRCTKCDGRGEKQCETCKGKCQLLTYIELKVEWKNHVEDHLVEQSCGLKSDKLRSVKGKELFKSSQNLVYPLLGFKPQAVSQASERLIKEHQTKYGKTSRILQQRQAVELIPITQVNYKWKDKSYVYYVYGNERKASADDYPETCCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASZ6</accession>
    <name>A0A3P9ASZ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASZ6"/>
    <dbReference type="Ensembl" id="ENSMZET00005000886.1">
        <property type="protein sequence ID" value="ENSMZEP00005000811.1"/>
        <property type="gene ID" value="ENSMZEG00005000708.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163564"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF337">
        <property type="entry name" value="PROTOCADHERIN 2 ALPHA A 3 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018074586" description="Cadherin domain-containing protein" evidence="10">
        <location>
            <begin position="31"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="123"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="239"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="426" mass="46412" checksum="9CBD809C8AC1F364" modified="2019-02-13" version="1">MGRSVDLGTQCWWVAISFSLMLSCVERVSTQIKYSVPEEVKVGSVVGNVAKDLGLDISSLEKRRFRIVSGVPFLVLQKSLDREKESEHKLILTAIDGGNPPRSGTVNVTVIVLDSNDNHPTFSQEVYYATVRENTDAGVFVIKLNATDLDEGLNGQIEYFFGEELKGNLYEIFNMDKDTGELRINGEIDFEKTDIFKLDVHATDKGQPPMSADCTVIISVLDVNDNKPEIEVTSLSKIVSEDSKPGTVVALISITDQDAGLNGKVICSLSDNIPFDLKPSFQDNMYSLVIKHKLDRESVSHYDVTITATDCGVPPLSTSRTLSIDVSDVNDNAPQFAQNPVELYLVAGSSPGLDSLGRCVFGQDTLLVAYWWWSEGPVAPVSGSLASVSAPQGGCGYNVACHHQCVNVCVNGWMTGCVKRFGALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATF3</accession>
    <name>A0A3P9ATF3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATF3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000687"/>
    <dbReference type="Ensembl" id="ENSMZET00005000760.1">
        <property type="protein sequence ID" value="ENSMZEP00005000687.1"/>
        <property type="gene ID" value="ENSMZEG00005000633.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244855"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="267"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118502" checksum="6444730DF1C644A9" modified="2019-02-13" version="1">MSILRMPLHTVTLTSSFVSGAVRVGVRDQLPIEGIDLILGNDLAGGKVFPATPEVIECPTSDRLCHFPSELGDSTVFPACVVTRAQARRLGGEVDISGMFPDGSEPHDSSVPGVDGGTAKVFSVVSEDLRLAVNREQLIAAQQADDTLSACRAAALQPGAVPGAASYEVDRGVLLRNWAPVGGLGGEVVTQVVVPTEYRPQVLSLAHEHHLSGHLGIKKTYDRVLRYFFWPGLKSDVACYCRSCHVCQVSGKPNQVIPPAPLHPIPAIGEPFEHVIVDCVGPLPKTKAGYQYVLTIMCAATRFPEAIPLRSLRAKAVVKALVQFFSIFGLPKYIQTDQGSNFLSGVFAQVMTELSVKHRVSSAYHPETQGALERFHQTLKAMLRKYCFETESEWDVGLPLLLFAIRETTQESLGFSPAALVFGHTVRGPLRLLQEGWLAQPDQPRPVHNVLDYVSSFRERLHAACELARRSLSGAQEKMKERYDRKTLKRTFLPGERVLVLLPIVGSCFQARFSGPYEIERQVSDTDYLIKTPDRRKKSRVCHVNMLKKYVDRNQSQTNSVSPVVTVGSPSYQPEVDGLREPQGPSSGARLENSKILEDLEAHLLYLGEPHRQDIYNLICGHIVLFSDKPTQTTMLEHDIDVGEHRPIKQHAYRVNPGKRAIMRKEVEYLLENGFAVPSFSPWSSPTLLVPKSDQTPRFCNDYRKVNAITKPDSFPLPRMDDCVDRVGSARFVTKLDLLKGYWQVPLSQRAAEISAFVTPDHFLQYTVMPFGLRNAPATFQRLMNMVLLGVQGCEVYLDDIVVYSLTWLEHMETLREVLVRLKGACLTVNLAKCEFGKAVVTYLGKQVGQGQVRPLMAKVQAVLDFPVPTTRRQLRRFLGMCGYYRGFCKNFATVVIPLTALTSPSCLFLWNSDCQDAFDSAKALLCSAPVLGAPDFTRVFKLEVDASAHGAGAVLLQEDDQGIDHPVCYFSRKFNKHQVNYSTIEKEALALLLALQHFEVYVSSSPAPTAVYTDHNPLVFLSRMRNNNQRLMRWSLLLQDFNIDIHHLRGADNIVADALSRVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATF6</accession>
    <name>A0A3P9ATF6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Butyrophilin subfamily 1 member A1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SKINT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATF6"/>
    <dbReference type="Ensembl" id="ENSMZET00005001052.1">
        <property type="protein sequence ID" value="ENSMZEP00005000974.1"/>
        <property type="gene ID" value="ENSMZEG00005000852.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244843"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042110">
        <property type="term" value="P:T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000088">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF151">
        <property type="entry name" value="ICOS LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="53"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="166"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="359"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="478" mass="54336" checksum="C76465746A22A69D" modified="2019-02-13" version="1">MFCLKDGRCCKMPLGAICVFLFHHFIFFFHLAQFCGGVSQVVGPSEPVVAIVGDDTVLPCHLDPAVNAADMTVEWTRSDLTPKFVHVWRDGVELVNKKNEAYMERTSLPINNLKLGDISLKLSKVKLSDRGSYKCFIPALSGQTSVELVVGVVSSIIITLMRNSADSSKVVLQCESAGWYPEPELLWLDGEGNLLSAGPAETLRGPDDLYTVSSRVTVEKRHSNNITCRVQQRNTNKSRETHIHVPGDLFNPPCSSAGHIIISVVVTVLLILAVVSVVWKYRSKHQGRNTKISTDHSERQPLTEKKREALHLTEDSSDTVDFDMTQENLNTWFKEGEEDKFHSIMVVQFLMSHKCDLENDIYELKLKLLELQKQHDENQSQLVNNIKQIEQNEKTSDKINEEEGIETETNFETMKENLETEIEEKETQRKSVLYGIDVMTEKKIELDDILYKIHTQREKIEKRRNEIQIQFQSGSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUE7</accession>
    <name>A0A3P9AUE7_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
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                <person name="Galibert F."/>
                <person name="Gante H.F."/>
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                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
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                <person name="Nishihara H."/>
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                <person name="Penman D.J."/>
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                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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            <authorList>
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            <authorList>
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    <sequence length="113" mass="12098" checksum="05D714CA1BCFCDF8" modified="2019-02-13" version="1">VESHEKGWTSHKDQLESPESGVRDGEVVVIADILTTRLAGVAIKVLLFVAPDLFTSHQEDQEPEDEDNGKPDSTKPCGVLVSPTEETLQEDPVHGVVSDVGAQGNQLELTALA</sequence>
</entry>
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    <accession>A0A3P9AXN1</accession>
    <name>A0A3P9AXN1_9CICH</name>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
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                <person name="Amemiya C."/>
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                <person name="Streelman J.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nectin family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
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    <dbReference type="PANTHER" id="PTHR23277:SF106">
        <property type="entry name" value="NECTIN-1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
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    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018270973" evidence="12">
        <location>
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            <end position="402"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="364"/>
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    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="16"/>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002197.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="402" mass="43849" checksum="6A5016F6A57ADC97" modified="2019-02-13" version="1">MDGAASFFGSFCHNIPAICDSALLRVLLVIVSLLCADVEALQVIGESVTVEQGGTAILSCYVTGTNDDLTQITWQRKTREKPHNDNFLTILPREGVQFVNGGDDRFKYIGNFNNNNGTLQLSSVALKDEGSYTCIFTFFPSGNQKTEITLNLLVPPFTNIKDNLPTLGTEEVLFATCTAAGSKPPAEVRWLTGALGEKVRTTTNSTQYDNDTTTTVSSLFGVPTREINGHQVQCVISGGSLSTDRSLSFTIQIYFSPTEVNISVISEDSFECVTEAKPNANFIWSRSGQSLLESAVKVDGAKLQLLSLTSDLNGLYQCEASNTYGSKRGQLYVHVASGSCSAAWALLGVLIFLSIVGAAVWYFYKHEDQRHRFALFWQRVPTNESAGDSAAQQEQHQTEQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AY00</accession>
    <name>A0A3P9AY00_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Linkage group 2 C4orf45 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AY00"/>
    <dbReference type="Ensembl" id="ENSMZET00005002674.1">
        <property type="protein sequence ID" value="ENSMZEP00005002561.1"/>
        <property type="gene ID" value="ENSMZEG00005002016.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000170113"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027814">
        <property type="entry name" value="DUF4562"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833">
        <property type="entry name" value="GENE, 17359-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833:SF1">
        <property type="entry name" value="GENE, 17359-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15123">
        <property type="entry name" value="DUF4562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="134" mass="15006" checksum="A7C3BB7B9BAF730F" modified="2019-02-13" version="1">MQNSETTAGQPQYGQRMIFTGPDGIGDYRPRSNYFTRYIGVGATSPEATGDLSYLCRAPPDALPPIPRQSYVGEVGWGWQYNQLLNSGTLLSNMQIKKTDIRASMPFPFAQRAITHVCFVMWIRENISGLHCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AY23</accession>
    <name>A0A3P9AY23_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AY23"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002558"/>
    <dbReference type="Ensembl" id="ENSMZET00005002671.1">
        <property type="protein sequence ID" value="ENSMZEP00005002558.1"/>
        <property type="gene ID" value="ENSMZEG00005002020.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177501"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="81" mass="8737" checksum="CF3D9E7D2E0F2B5F" modified="2019-02-13" version="1">FPASFSPRTSGIVGGTSDATAGSWPWMASLQKNGSHVCGGTLVALDSVLTEVEVCTDDNSHMSQHISQHRRQKLRRGWVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZC6</accession>
    <name>A0A3P9AZC6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZC6"/>
    <dbReference type="Ensembl" id="ENSMZET00005003129.1">
        <property type="protein sequence ID" value="ENSMZEP00005003013.1"/>
        <property type="gene ID" value="ENSMZEG00005002340.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000204763"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF14">
        <property type="entry name" value="BUTYROPHILIN SUBFAMILY 2 MEMBER A2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
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        <location>
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            <end position="176"/>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="183" mass="20916" checksum="D50F9F0910FC2D0F" modified="2019-02-13" version="1">AKLKNITAESGLNVTLPCRAPNNNILISVVEWSRPDLKRDEYVILYRDNQLHPDYQDPSFKGRVDLQDNQMKDGDVSLVLKDVTISDAGTYECRIIQRTGTTRMKRTWLTTDPINIINLSVVPSGEFEFSVCSLKRKLILVCASVITFLSLTPISHLQIHQEDTERTDGRKMDLRNKQNKTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1G1</accession>
    <name>A0A3P9B1G1_9CICH</name>
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        <submittedName>
            <fullName evidence="3">Solute carrier family 43 member 3</fullName>
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        <name type="scientific">Maylandia zebra</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
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                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="470"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
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                <person name="Jaffe D.B."/>
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                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
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                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
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                <person name="Rakotomanga M."/>
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                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254:SF14">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
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        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017981413" evidence="12">
        <location>
            <begin position="18"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="276"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="680" mass="75278" checksum="461C3E38D7636EEB" modified="2019-02-13" version="1">MQAVCWLLCLSLAGASAVVHKDQVAQHAVKLYRSKRAAHGQSWVAGNCKRLVGLLRQKNVVFKKLEAAADAVGKDRSLSETEKHFQVHTLEVLQKELNESEHLVFQALHSLQRALQGDYKDVVNMKESSRQRLEALREAAIKEEQEYVELVAAEKHQQEAVKSALAQNKTLSILDEILEDVRKAADRLEEEIEEHAFDNNKQMKGVNVEAVLRVEDDEENGSKRKNKSRQKEVEDDLGLSMLIDSQNNQYVLTKPRDSTMPRADHHFIKDLVSVVMLSLPCGWICTLAGLPPMFGYIICGVLLGPSGLNSIKSMVQVETLGELGVFFTLFVVGLEFSPERLRKVWKISVQGSCSLSLLMVGAGLLWGQVLHIRPTQTVFISTCLSLSSTPLVSRFLAGGSRGDKEAELDYSSVLLGMLVMQDVQLGLFIAVMPTLIQAQSGELDGCVGLSVVIACVLHVLYLLAQVLVSLAAVLLLCLLFRSFLIGPFYKKLHTESKGNREILVLGMAAFVFFMLTVTEVLDVSMELGCFLAGALLSSQGHMVTAEVMGCIEPIRDFLAIIFFASIGFHVFPTFVLYELTILLALTLTLVIMKFMMAVLVLSAILPPGSRHIQWIVSAGLAQVSEFSFVLGSRARRAGIISREVYLLVLSVTTLSLLLAPLLWKVTTHRWVPRTERRPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3R2</accession>
    <name>A0A3P9B3R2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with anxa5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004549254.1">
        <property type="nucleotide sequence ID" value="XM_004549197.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3R2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004540"/>
    <dbReference type="Ensembl" id="ENSMZET00005004742.1">
        <property type="protein sequence ID" value="ENSMZEP00005004540.1"/>
        <property type="gene ID" value="ENSMZEG00005003524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481531"/>
    <dbReference type="KEGG" id="mze:101481531"/>
    <dbReference type="CTD" id="335888"/>
    <dbReference type="GeneTree" id="ENSGT00940000156206"/>
    <dbReference type="OrthoDB" id="10037309at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007369">
        <property type="term" value="P:gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13195">
        <property type="entry name" value="FERM_C_MYLIP_IDOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17104">
        <property type="entry name" value="FERM_F1_MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16523">
        <property type="entry name" value="RING-HC_MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000019">
        <property type="entry name" value="E3 ubiquitin-protein ligase MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000129">
        <property type="entry name" value="E3 ubiquitin-protein ligase MYLIP isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000164">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000175">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041790">
        <property type="entry name" value="MYLIP_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0306">Gastrulation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FERM" evidence="16">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="481" mass="54618" checksum="689AEA08F886E9A5" modified="2019-02-13" version="1">MLCHVTRPDSVVMEVEVDAKANGEDCLNKVCRKLGIIEVDYFGLQFTGSKGENLWLNLRNRISQQMDNLTPCRLRLRVKFFVEPHLILQEQTRHIFFTHVKEDLHNGHLRMGSEQAEELSALLAQAEFGDYNQNTAQYWYSELCGEEPSPATIDSIISRHKTLEGLSQGSVEYQALQLVSSLEHYGVEWHWARDADGQRMAIGVGPEGIAICKEDFSLVNRISYPIIQIATQSGKSVYLTVTKDTNDSVVLLFKLISNRAASGLYRAITETHAFYRCDTVTNAVMMQYSRDFKGHLASLFLNENINLGKKYVFDIRRTAKEVYDHARRALYNSGVVDLISRSESRDRYSPSRSPSRDGEQDKGLDCGSCQQSRALQERLQKLREALLCMLCCEEEIDAAFCPCGHMVCCQTCANQLQLCPVCRSEVEHVQHVYLPTCTSLLNLTLTDNHQHRSNIPAPIHRDTASPHTCSTTEYEHKLYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B744</accession>
    <name>A0A3P9B744_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B744"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005706"/>
    <dbReference type="Ensembl" id="ENSMZET00005005956.1">
        <property type="protein sequence ID" value="ENSMZEP00005005706.1"/>
        <property type="gene ID" value="ENSMZEG00005004417.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164961"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="90"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="365" mass="40438" checksum="4C8978CD21726070" modified="2019-02-13" version="1">GGALLTSTEKIVGRWKEYFEDLLNPTDTSSGEEAESGDEGCDPPISGGEVTEAVKQLLGGRAPGVDEVRPEFLKALDVVGLSWLTRLCNVAWRSGAVPVDWQTGVVVPIFKKGDRRVCSNYRGITLLSLPGKVYARVLERRVRPLVEPRIQEEQCGFRPGRGTLDQLFVLSRILEGAWEFAQPVYMCFVDLEKAFDRVPRGVLWEVLREYGVSGPLLRAIQSLYNRCRSLVRIAGNKSDSFPVGDGLRQGCPLSPVLFIIFMDRISRRSQVAEGFRFGGLRISSLIFADDVVLLASSGEGLQLALERFAAECNAAGMRISTSKSEAMVLSRKRVECPLRVGDEFLPQVEEFKYLGVLFASDGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BA37</accession>
    <name>A0A3P9BA37_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase 8-like 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BA37"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005062"/>
    <dbReference type="Ensembl" id="ENSMZET00005005286.1">
        <property type="protein sequence ID" value="ENSMZEP00005005062.1"/>
        <property type="gene ID" value="ENSMZEG00005003928.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005007054.1">
        <property type="protein sequence ID" value="ENSMZEP00005006754.1"/>
        <property type="gene ID" value="ENSMZEG00005005207.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182932"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF58">
        <property type="entry name" value="8B (PUTATIVE,_PSEUDO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="227" mass="25780" checksum="52F52B800F459FE8" modified="2019-02-13" version="1">MTPYEQLVIRRYRPADKDTVLTLFSTGTLEHIRPCFYNAMTSPLYLTITSTLCVVGYLLGSVFGAVLFPAAWVGLIYCCCHEVYAYYVRYKLRTDMQDIPGNFLSRPDDCFWVAEAEVGARAQVVGMVAVVAKHSGTEKYGEMFRMIIFPQYRRMGLGFRLTQTAVDFCKERGFSKVVLETSSTQMAAVALYSKVGFNRVQSHIKAQAAHWIISLARVTIIRMEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBH6</accession>
    <name>A0A3P9BBH6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small glutamine-rich tetratricopeptide repeat-containing protein beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-SGT</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homooligomerize.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBH6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007242"/>
    <dbReference type="Ensembl" id="ENSMZET00005007552.1">
        <property type="protein sequence ID" value="ENSMZEP00005007242.1"/>
        <property type="gene ID" value="ENSMZEG00005005575.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158321"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000002">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000103">
        <property type="entry name" value="small glutamine-rich tetratricopeptide repeat-containing protein beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF1">
        <property type="entry name" value="SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="12">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="11">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="302" mass="34350" checksum="C6F0B25857909036" modified="2019-02-13" version="1">MAVEKRLAFSIVQFLRDQTHCGTLNSDEQESLEVAIQCLETTFKISSSDCHLAVPQSLREIFLNALLKNDNLTIPESSPSPEDIERAELLKNEGNNHMKEENYRSAVECYTKAIDLDLRNAVYYCNRAAAHSKLGNYTEATSDCERAIGIDPTYSKAYGRMGLALTAMNKYPEAITYFKKALVLDPENDTYKSNLKIAEQKQKEATSPVTGLGFDMASLINNPAFISMVREPQDWQQALFFLRTEQFVVLFLFLLKRIQLSYLSLRGQQFAQQIQQQNPELIEQLRNHIRSRSFSGSAEEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBS5</accession>
    <name>A0A3P9BBS5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBS5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007342"/>
    <dbReference type="Ensembl" id="ENSMZET00005007652.1">
        <property type="protein sequence ID" value="ENSMZEP00005007342.1"/>
        <property type="gene ID" value="ENSMZEG00005005640.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183142"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.100:FF:000004">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000109">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 14" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="16">
        <location>
            <begin position="60"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="377" mass="41888" checksum="7DB6AAD496BA7906" modified="2019-02-13" version="1">MGRAAARVLLSQTFSPVMAASGKLASFRLPPLPTVGELIKLYNLRAEKQLSQNFLLDLRLTDKIVRQAGSLRDAHVCEVGPGPGGLTRSILNAGAADLLVVEKDTRFIPGLKLLSEAAPGRLRIVHGDILTYRLDRGFPTNISKPWEGDPPNLHIIGNLPFSVSTPLIIKWLENVANRTGPFTFGRTRLTLTFQKEVAERLTASTGSKQRSRLSIMAQYLCTVHNCFTIPGRAFVPKPEVDVGVVHFTPLVQPQIQQPFQLVEKVVRNVFQFRRKHCHKGVEKLFPEARRVELTQEMMQQADVDPILRPTELTIPQFRALADAYARLCAHEPALLTYEFREELRLKHVARKSNTASSPTLTDAPSGVAESSATPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BC64</accession>
    <name>A0A3P9BC64_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Granzyme B(G,H)-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BC64"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007487"/>
    <dbReference type="Ensembl" id="ENSMZET00005007801.1">
        <property type="protein sequence ID" value="ENSMZEP00005007487.1"/>
        <property type="gene ID" value="ENSMZEG00005005717.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144271"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000010">
        <property type="entry name" value="Kallikrein related peptidase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF87">
        <property type="entry name" value="ARGININE ESTERASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018114460" evidence="6">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="250" mass="27844" checksum="A2DE9B65DB94EAC2" modified="2019-02-13" version="1">NLFIVFIILMVLIWYISAVHEIIHGTKAPENSMHYMASVQNKKGEHVCGGFLMTEDFVVSAAHCDGSLTHVVLGNHNLKKGSHQKIKIENKTIHENYQQVGLGNDIMLIKLSEKVKLGHGVEKIKLPQAEINLKENQVCQVAGWGTTKTHGKPVDELRVVDVSVIQRKVCEPQWPGLPANVICAGGYETDKGFCQGDSGGPLVCDGLAVGIVSFNYKENCSYPNKPNIYTDISKYLQWINRIVKSRKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BH49</accession>
    <name>A0A3P9BH49_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
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        <property type="nucleotide sequence ID" value="XM_004539666.4"/>
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        <property type="nucleotide sequence ID" value="XM_024806265.1"/>
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        <property type="protein sequence ID" value="ENSMZEP00005009240.1"/>
        <property type="gene ID" value="ENSMZEG00005006987.1"/>
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    <dbReference type="KEGG" id="mze:101471905"/>
    <dbReference type="CTD" id="6530"/>
    <dbReference type="GeneTree" id="ENSGT00940000158960"/>
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        <property type="component" value="LG1"/>
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        <property type="term" value="C:axon"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:neuronal cell body membrane"/>
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        <property type="term" value="C:presynaptic membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:dopamine:sodium symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:amino acid transport"/>
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        <property type="term" value="P:dopamine uptake involved in synaptic transmission"/>
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        <property type="entry name" value="SNS_sf"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NANEUSMPORT"/>
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    </dbReference>
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
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            <begin position="73"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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            <end position="503"/>
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    </feature>
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        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="81"/>
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        <ligand>
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            <position position="82"/>
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        <ligand>
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        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        <location>
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            <end position="193"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU003732"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="OSCP1"/>
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        <property type="entry name" value="OXIDORED-NITRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR21439:SF0">
        <property type="entry name" value="PROTEIN OSCP1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF10188">
        <property type="entry name" value="Oscp1"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009400.1"/>
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        </source>
    </evidence>
    <sequence length="380" mass="42705" checksum="5E5FE104EA0F07B3" modified="2019-02-13" version="1">MSSRTLPLLFINLGGEMLYILDQRLRAQNIPADKAKKVMNDIITTMFNKKFLEELFKPQELYSKKALRTVFDRLAHASIMRLNQASMDKLYDLMTMAFKYQVLLCPRPKDILLVSFNHMDAIKDFVKDTPSILSQVDETYRQLIEMYTPLSSGEFQLIRQTLLIFFQDMHIRVSIFLKDKVQNSNGRFVLPTSGPVPHGTQVPGLIRMFSCTGEEFTRLKFNNGGNYTTALREGSFDIFGDRVTKLGTNMYSVSRPVETHMSGTSKNSAQHTKVSAAPNPLAKEELNLLARLMGGLEVQKPGNADTGFRISLFATDEEEEEALISRPDELSYGVINIQATKDQQANAELAKIMGEFTESGDQSPSVSNKGDDLLAMMDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BI79</accession>
    <name>A0A3P9BI79_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">T-box transcription factor TBX21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">T-cell-specific T-box transcription factor T-bet</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription factor TBLYM</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BI79"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009620"/>
    <dbReference type="Ensembl" id="ENSMZET00005009979.1">
        <property type="protein sequence ID" value="ENSMZEP00005009620.1"/>
        <property type="gene ID" value="ENSMZEG00005007278.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156994"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021902">
        <property type="term" value="P:commitment of neuronal cell to specific neuron type in forebrain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072676">
        <property type="term" value="P:lymphocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010975">
        <property type="term" value="P:regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000011">
        <property type="entry name" value="T-box transcription factor TBX21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032385">
        <property type="entry name" value="T-box_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001699">
        <property type="entry name" value="TF_T-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018186">
        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF88">
        <property type="entry name" value="T-BOX BRAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16176">
        <property type="entry name" value="T-box_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="T-box" evidence="16">
        <location>
            <begin position="208"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="560"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="662" mass="72036" checksum="EE4CE08B0D5B47A3" modified="2019-02-13" version="1">MQVENCISPASDLSKKFMNVGSGFSSSNGSELSLQDHPIISASDNLERSSPLKKNSREMTNQSEADNFPDSKDASGDVQRGKLSPDLHGVSDIRHNFDGSAGERCIFSPSTQPQSVSAAPSAMFPYPSQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLTNTSPQGYPTAGYPYAQQYGHTYQGGAFYQFSSAQAGLVPGKAQVYLCNRALWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVIGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNTGQMVVLQSLHKYQPRLHVVEVNEDGTEDTNQPGRVQTFTFSETQFIAVTAYQNTDHSSIYTLNISCDIDRLTPSPGDSPRSQIVPGARYAMPSSFLQDQFVSTYAKSRFHPGVGTGPGTERSVPLGNSLLSPQQTEEPSVATPPQRWFVTPANNRLDFAASAYDAADFAGNAATLLSYAAAGVKALPLPTAGCSNRPLGYYADPSGWGGRTPPQYCGVNSKSSSVFSCWPTNTIGGRTGTSYLSEEGDSITTERSPIGGSEETKPKDMTSESSWIETPSSIKSIDSSDSGIFEQAKRRRISPSATPVSETVSPLKSELLTPRECEKNCTKDIGYYSFYPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ07</accession>
    <name>A0A3P9BJ07_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ07"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009868"/>
    <dbReference type="Ensembl" id="ENSMZET00005010230.1">
        <property type="protein sequence ID" value="ENSMZEP00005009868.1"/>
        <property type="gene ID" value="ENSMZEG00005007466.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177007"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051503">
        <property type="entry name" value="ComplSys_Reg/VirEntry_Med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45785:SF2">
        <property type="entry name" value="COMPLEMENT FACTOR H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="369" mass="41706" checksum="DB3040D91C50B775" modified="2019-02-13" version="1">YTCWFSCGLPLTAGAALLLDDLKMCIKYFAFALLWFPGVLHAQSTTQACDAPTLDGGFFAPKQETYSQGTKLSYTCNEGRTLAMKGWWATSTCHNGKWSHQLQCIGKSSTNKRPCSGINNVFESKSNFTESMNACSVPPKIPHAVIVHQDYQEVFAAGSEVQYECEDGYTAEGAHNTKSVCTQGSWTQGPTCRSSNEGDTRLRYTTMHYLSDSLVCFQKYSCVFISVQSCGNFPVIENAVAQQTSRYYLIYRCQRLYRLVGPERVKCISSGTWSNLPECRVNFCAVNTNDNPEYKSVGTVHIENGEEERVECVKPHSWSFEHYSKVRCINGRVEATNCKYYCKLSMFERVSQKSFQCCVAYMLPRFYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ36</accession>
    <name>A0A3P9BJ36_9CICH</name>
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        <submittedName>
            <fullName evidence="11">Uncharacterized LOC112430976</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ36"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009716"/>
    <dbReference type="Ensembl" id="ENSMZET00005010076.1">
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        <property type="gene ID" value="ENSMZEG00005007359.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF111">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07686">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018281098" evidence="9">
        <location>
            <begin position="24"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="213" mass="23686" checksum="CE76BBC046E3D4B2" modified="2019-02-13" version="1">MRNFDSLTVLLVCSLSWIPVSQPVEVQSGKEVTLLCSNFSSSPTQILWFRVTKRAKLTCIASMFEPHEPASFCTGFKNGKFEMSTNLSTVFLKIKQVDLLDSGLYFCGFKIDRSPVIVEATDLVVQGKNDLFICVILGVLTVFLITVIVCLAVKIKKLQKGIFIRQSSEHLHYAAVTFHPKTESPHRPASATEVDSDVIYRALHGTEVSLLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJS1</accession>
    <name>A0A3P9BJS1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJS1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010167"/>
    <dbReference type="Ensembl" id="ENSMZET00005010536.1">
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        <property type="gene ID" value="ENSMZEG00005007686.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176861"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08330">
        <property type="entry name" value="CARD_ASC_NALP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000013">
        <property type="entry name" value="Apoptosis-associated speck-like protein containing a CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033516">
        <property type="entry name" value="CARD8/ASC/NALP1_CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051249">
        <property type="entry name" value="NLRP_Inflammasome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985:SF2">
        <property type="entry name" value="APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="6">
        <location>
            <begin position="65"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="151" mass="17013" checksum="9B4784683D939272" modified="2019-02-13" version="1">MAANFLLLNSDQTELIVLGPEKLRNMVSKQILTLDGITLASSNAVRNLGVISDQDMSFNALAVIFPSGQNHFVDAHDVELIHRVSNIERILEELKEKIIQQEAYDEIRAQQTSQEKMRKLYSGPLKAGDASKEAFYQSLKKHEKMLIDDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLV1</accession>
    <name>A0A3P9BLV1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin thioesterase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C65 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="RefSeq" id="XP_004567151.1">
        <property type="nucleotide sequence ID" value="XM_004567094.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLV1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010909"/>
    <dbReference type="Ensembl" id="ENSMZET00005011287.1">
        <property type="protein sequence ID" value="ENSMZEP00005010909.1"/>
        <property type="gene ID" value="ENSMZEG00005008193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466582"/>
    <dbReference type="KEGG" id="mze:101466582"/>
    <dbReference type="GeneTree" id="ENSGT00390000006979"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000780">
        <property type="term" value="P:negative regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22763">
        <property type="entry name" value="OTUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.20:FF:000001">
        <property type="entry name" value="Ubiquitin thioesterase OTUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016615">
        <property type="entry name" value="Otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF33">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013503">
        <property type="entry name" value="Ubiquitin_thioesterase_Otubain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="88"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="9">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR013503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="279" mass="32051" checksum="942A5B012D93CE5C" modified="2019-02-13" version="1">MSCGGRKPISAAKMAEEQQESSQGEMEGVNCLAYDEAIIAQQDRIQQEIANSNPLVSDRQDLSVLQSEYAEDDTVYQLKIKDLHKKYSYIRKTRPDGNCFYRAFGFAHLESLLDDSKELQRFKAVAAKSKLDLVNEGFTEFTIEDFHNTFMDLIELCEKQPSLQELLNSFNDQNVSDYVVVYLRLLTSGYLQRQHTFFQHFIEGGRTVKEFCQQEVEPMSKESDHIHIIALAQALDVSILVEYMDRGEGGTVNHHVFPEGGDPRIFLLYRPGHYDILYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLX0</accession>
    <name>A0A3P9BLX0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family with sequence similarity 177 member A1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004559364.1">
        <property type="nucleotide sequence ID" value="XM_004559307.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLX0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010930"/>
    <dbReference type="Ensembl" id="ENSMZET00005011308.1">
        <property type="protein sequence ID" value="ENSMZEP00005010930.1"/>
        <property type="gene ID" value="ENSMZEG00005008206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483306"/>
    <dbReference type="KEGG" id="mze:101483306"/>
    <dbReference type="CTD" id="283635"/>
    <dbReference type="GeneTree" id="ENSGT00390000016736"/>
    <dbReference type="OrthoDB" id="45963at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028260">
        <property type="entry name" value="FAM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206">
        <property type="entry name" value="LP10445P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31206:SF5">
        <property type="entry name" value="PROTEIN FAM177A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14774">
        <property type="entry name" value="FAM177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="214" mass="24381" checksum="BABF4ED87684D530" modified="2019-02-13" version="1">MADLSLYLANVNVTLGQTMETEKSTGGEAEFDTVEMGDPVGTPRKVKVPRRTIYFANGETMEEYSTDEEEEEEQTAKKEVISVDPSKLTWGPYFWFQMWRMATSTVSVCDYMGEKLASLFGITTPKYQYAIDEYYRIKKEEEEEEEENRLAEEAEHRFGEQQRGKRGDPTAPRLATVEQPEVSPASFVNISFELEPEPPLSNQDPNRVPSPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BM39</accession>
    <name>A0A3P9BM39_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM-domain binding 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the LDB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539042.1">
        <property type="nucleotide sequence ID" value="XM_004538985.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004539043.1">
        <property type="nucleotide sequence ID" value="XM_004538986.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BM39"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010997"/>
    <dbReference type="Ensembl" id="ENSMZET00005011376.1">
        <property type="protein sequence ID" value="ENSMZEP00005010997.1"/>
        <property type="gene ID" value="ENSMZEG00005008245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479469"/>
    <dbReference type="CTD" id="30576"/>
    <dbReference type="GeneTree" id="ENSGT00390000005639"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030274">
        <property type="term" value="F:LIM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000063">
        <property type="entry name" value="LIM domain-binding protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041363">
        <property type="entry name" value="LID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17916">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51957">
        <property type="entry name" value="LID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LIM interaction" evidence="6">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="412" mass="46640" checksum="E0B5CA89FED9E354" modified="2019-02-13" version="1">MSVGGCACPGCSSKSFKLYSPKEPPNGSTFPPFHPGTMLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIYELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKESFHNNFVSLDCDQCTMVTQNGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDSQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPSRQAPNKRRKRRMSGGSTISGGGGTNNNNNNKKKSPGSGFPLSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGSNSPWNNKAPSSQESKSDNPTSQASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BPV0</accession>
    <name>A0A3P9BPV0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hepatoma-derived growth factor-related protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HDGF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555022.1">
        <property type="nucleotide sequence ID" value="XM_004554965.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BPV0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011960"/>
    <dbReference type="Ensembl" id="ENSMZET00005012369.1">
        <property type="protein sequence ID" value="ENSMZEP00005011960.1"/>
        <property type="gene ID" value="ENSMZEG00005008974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481066"/>
    <dbReference type="KEGG" id="mze:101481066"/>
    <dbReference type="CTD" id="84717"/>
    <dbReference type="GeneTree" id="ENSGT00940000153942"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061628">
        <property type="term" value="F:histone H3K27me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062072">
        <property type="term" value="F:histone H3K9me2/3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20149">
        <property type="entry name" value="PWWP_HDGFL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000017">
        <property type="entry name" value="hepatoma-derived growth factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036218">
        <property type="entry name" value="HIVI-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021567">
        <property type="entry name" value="LEDGF_IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF18">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11467">
        <property type="entry name" value="LEDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140576">
        <property type="entry name" value="HIV integrase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="13">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="574"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="470"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="577"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="608"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="671" mass="74139" checksum="9F4134CD699C46E0" modified="2019-02-13" version="1">MPHNFQPGDLVFAKMKGYPHWPARIEDVADGAVKPPPNKIPIFFFGTHETAFLAPKDLFAYEKYRERYGKPNKRKGFNEGLWEIQNNPHASYSAPPVPASSSDSEAENAGGGSDEEDDEEDAPVPRKAQTGSEVDSDSGSEDRGRGGGGGGGGGGGGGGGMKRKPQAPKRPPPPKKARGSSSDRDEEESGSPSESEPTPSESDSGKNSDQDFTPEKKSGGRGVKKAGGRGKKKKASSDSDSDSGSASEKKVADSDSEDEKPRPALSGSESQSGSKSESESDPPPRKGPQARKKEKPAPKPRARKPKPAPAKRAPSSSSDSESDSEPDRISEWKKRDEERRRELEERRKKEEAEELRRLREREKEEEEKKKKDKDKAKKESDSDSSSSSDEGIDDHPLKKSKKPPPPPIPAPSDSDSPPPAEVKKPPKKLDNQKKAKIKKEKERKERKERELKEKKARRSEERSRARSKPEKLKRKPEKLPEKKVEKKKEPSPGERLQKLHTDIKFALKVDNPDIERCLQALEELEAVPVTSQILHKNAEVIATLKKIRRYKASTAVMEKASDVYNKLKLRFVGKAEVAAKPKTENKEPENDEEKETENTDSTPVNGESEQKKNDTEGEEKPKSPIQDENNVDTASSPNRRSPDSSAEQQTHTYEEEDNSISAETEQPAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQM9</accession>
    <name>A0A3P9BQM9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leucine-rich repeat and fibronectin type-III domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the LRFN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559318.1">
        <property type="nucleotide sequence ID" value="XM_004559261.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004559319.1">
        <property type="nucleotide sequence ID" value="XM_004559262.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012776802.1">
        <property type="nucleotide sequence ID" value="XM_012921348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQM9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012255"/>
    <dbReference type="Ensembl" id="ENSMZET00005012685.1">
        <property type="protein sequence ID" value="ENSMZEP00005012255.1"/>
        <property type="gene ID" value="ENSMZEG00005009212.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471592"/>
    <dbReference type="KEGG" id="mze:101471592"/>
    <dbReference type="GeneTree" id="ENSGT00940000156417"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05764">
        <property type="entry name" value="IgI_SALM5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000235">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000045">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000091">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000019">
        <property type="entry name" value="leucine-rich repeat and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF6">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018001531" description="Leucine-rich repeat and fibronectin type-III domain-containing protein 2" evidence="19">
        <location>
            <begin position="21"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="289"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="413"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="604"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="785" mass="86255" checksum="5A5F92F574914335" modified="2019-02-13" version="1">MDKVVISLLFLGTAFTMVHACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFILKISTLDFANMTGLVDLTLSRNTISDIQPFSFIDLETLRSLHLDSNRLTELGPDDLRGLVNLQHLILNNNQLSRISKVAFDDLLLTLEDLDLSYNNLRTVPWEAIRKMVNLHQMSLDHNLISFIAEGTFTDLDKLARLDLTSNRLQKLPPDPIFARSQSNVVMSTPYAPLLSLSFGGNPLHCNCEVLWLRRLEREDDMETCASPASLKGRYFWSVREEEFVCEPPLITQHTHKLLVLEGQTASLRCKAVGDPMPTVHWVAPDDRLISNSSRATVYENGTLDITVTTSKDYGTFTCIAANAAGESTASIELSIIQLPHLSNGTNRTTQNKSGLSDITSSTKISKGEPKTLPEKVVSVSEVTAVSALVKWSVSKATPKVKMYQLQYNCSEDEVLIYRMIPMTNRAFVLTNLVPGMQYDLCVLAIWDDTATTLTATNIVGCVQFVTTEDYPQCQSIHSGFMGGTMILVIGGIIVATLLVFIIILMVRYKVTSGIQTNKLPTVSNTYSQTNGGMNRFNGAPPQVKSTVVVMREEMVEFKCGSLQSSLSSSSSSSNSLDSQTARGAGDRYSMQSSECTTLPSNKFRRHGPKARPNLDHLLGAFTSLELRGAGRDGAGTSGPSTSSNAMAVAVVPPSDKEPLLGRAESTTMLGRILGLPQEGKPKRSHSFDMGHVGATQSRSSYPRRISNIWTKRSLSVNGMLLQYDDSEDEKPSFESSEWVMESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQS6</accession>
    <name>A0A3P9BQS6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="9">MAD homolog</shortName>
            <shortName evidence="9">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024658615.1">
        <property type="nucleotide sequence ID" value="XM_024802847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQS6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012283"/>
    <dbReference type="Ensembl" id="ENSMZET00005012715.1">
        <property type="protein sequence ID" value="ENSMZEP00005012283.1"/>
        <property type="gene ID" value="ENSMZEG00005009232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470588"/>
    <dbReference type="CTD" id="4086"/>
    <dbReference type="GeneTree" id="ENSGT00940000154391"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061515">
        <property type="term" value="P:myeloid cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10497">
        <property type="entry name" value="MH2_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF23">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="11">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="12">
        <location>
            <begin position="273"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="467" mass="52544" checksum="FCD38657BAC75894" modified="2019-02-13" version="1">MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELERALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKALECCEYPFGSKQKDVCINPYHYKRVDSPVLPPVLVPRNSEFNAKHTMLPRFRNPLQQNEPHMPQNATFPESFGQANTLPFPHSPGNSYPNSPGSGSSVTFPHSPSSSDPGSPFQMPETPPPAYMPPEEQMSQDCPQPMDTNLMAPPLPLESNNRADVQPVAYEEPKHWCSIVYYELNNRVGEAFQASSTSVLVDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAELLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRF4</accession>
    <name>A0A3P9BRF4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carnitine O-acetyltransferase a</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024659136.1">
        <property type="nucleotide sequence ID" value="XM_024803368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRF4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012513"/>
    <dbReference type="Ensembl" id="ENSMZET00005012954.1">
        <property type="protein sequence ID" value="ENSMZEP00005012513.1"/>
        <property type="gene ID" value="ENSMZEG00005009404.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101484090"/>
    <dbReference type="GeneTree" id="ENSGT01150000286917"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019254">
        <property type="term" value="P:carnitine metabolic process, CoA-linked"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000002">
        <property type="entry name" value="Carnitine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF50">
        <property type="entry name" value="CARNITINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="51"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="630" mass="71252" checksum="8CD5FB8568B9F69B" modified="2019-02-13" version="1">MILRFCTRTVVKMGMVKPCALVSSCHLMKPVSRTWVNGRCLTYQQALPTQPVPTLQHTCERYLILLEPFVEVNELKRTKQLVQEFLKPGGVGEKLQKGLEKKALNTDNWLADYMVQTDYLDNRLPVVAYSNISGSFPRMDFRDKQGQIRCAAKVIRAILDFKTMIDNETIPVDYLRGKPLCMNQYSQLLSSCRIPGLEMDSVVFHGKTSYPSRYITLAYNSQFFMVDVYNSDGTPLTVHQLCVQLERICSSSLETSTEPVGILTSLNRDSWSKCYDRLIQDKPNKEALSAIQRSICVVCLDKAMPQVPDDMYSRGNVLQMMHGGGSQWNSANRWFDKSVQFIIGEDGAFGNNVSHSCADGTIGMTLTDYVSASIKKLEIIESPTVPLPTPQKLHFNITADIKKAIEEAKQSIDKIVQDLDFSILSFSHYGKNFLKANKMSPDPFIQMAIQLAYYRVHRQHCASYEAASMRLFRQGRVGEIPSTSSASVAFVMAFNDPNKKNTEKVDLLRKAIEVHKWNTSMEISGQTVFGHFLGLQHQATEKNIPMPDIFTDASFDRVFDYRLATSQVQSKSGCLPCACPYQRKTYDICYTLLKDDMAFVMSAFKTNTENNSEELKKAVEDALLDMRTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BS88</accession>
    <name>A0A3P9BS88_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 7 member 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004544242.2">
        <property type="nucleotide sequence ID" value="XM_004544185.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BS88"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012784"/>
    <dbReference type="Ensembl" id="ENSMZET00005013228.1">
        <property type="protein sequence ID" value="ENSMZEP00005012784.1"/>
        <property type="gene ID" value="ENSMZEG00005009596.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101486080"/>
    <dbReference type="CTD" id="6545"/>
    <dbReference type="GeneTree" id="ENSGT00940000154637"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF4">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="8">
        <location>
            <begin position="562"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="671" mass="73135" checksum="F2A6464DD79B541E" modified="2019-02-13" version="1">MATCPRGCAPAVRLCQKLNRLKTLEDDMMATSLKRCLSTLDLTLMGVGGMVGSGLYVLTGTVAKDTAGPAVIISFVFAGIASLLAAFCYAEFGARIPKTGSAYMFTYVSVGELWAFLIGWNVILENMIGGAAVARAWSGYLDSIFNHAIQNFTETHIMQWNVPFLAHYPDLLAAGILVVASFFISFGVQVSSYLNHIFSTVSMGVIVFILVFGFVLAEPANWSQEQGGFAPYGMSGILAGSATCFYAFVGFDVIASSSEEAKNPQKAVPIATAISLGLAATAYILVSTVLTLMVPWHTLDPNSALADAFFRRGYSWAGIVVAVGSICAMNTVLLCNLFSLPRIVYAMAEDGLFFSIFARVNPITKVPVNAILVFGILMATMALIFDLEALVQFLSIGTLLAYTFVAASVIVLRFQPEKTSSKGTPSTSPIPNNEPSPAPLESQTISEDSEEPKQYESFSDKLQLVERQKQKERRGVGQLKACWEPYLDRLLGDCEPGEVVAFCVLTLIVSSVSLCVVLEFGKKQLQLPLWSFTMLLVIFSLAYILSLAIIWVHEPQRNNKTFQVPLVPLTPGASILFNVFLMMKLSLLTWIRFTVWIAIGLFVYFGYGIWHSKEGIRELQPKDMAARYVVLPSGSLVETVQSVQPDSQLDTSAHHIDSPAASAAEECNRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTE1</accession>
    <name>A0A3P9BTE1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTE1"/>
    <dbReference type="Ensembl" id="ENSMZET00005013624.1">
        <property type="protein sequence ID" value="ENSMZEP00005013174.1"/>
        <property type="gene ID" value="ENSMZEG00005009892.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00630000089884"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000051">
        <property type="term" value="P:negative regulation of non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002040">
        <property type="term" value="P:sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031248">
        <property type="entry name" value="RNF213"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605:SF21">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF213-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22605">
        <property type="entry name" value="RZ-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="290" mass="32999" checksum="D42C9B2593236D5D" modified="2019-02-13" version="1">MLSSPSNCPTHRSSFWTLPEIITVERFSQLVEEKQGQSRISETQLTLCHPERELLPLVLAHCQYTLKKGGETDSSYDLPIIQTQLARRFLAGKPLIKDTSRYLNRHLQDFSMEPLKGSVSSALKTVLRSYTDVCDAVFVMEIGLRFLGKTGGEPQGQLLSYLTDSLQMGPQISSTVGLGQSKLEHSIFTWQLLTCWKSELMLNRKQKLPSEFQEKLSEEQKKDLKAFLAVTDVDTFSLELHEILLIRSTLEIHLEVKDLPPLPELESLPEEIRLGQSADVWRAAVEFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTI4</accession>
    <name>A0A3P9BTI4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555564.1">
        <property type="nucleotide sequence ID" value="XM_004555507.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTI4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013263"/>
    <dbReference type="Ensembl" id="ENSMZET00005013715.1">
        <property type="protein sequence ID" value="ENSMZEP00005013263.1"/>
        <property type="gene ID" value="ENSMZEG00005009972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475575"/>
    <dbReference type="KEGG" id="mze:101475575"/>
    <dbReference type="GeneTree" id="ENSGT00950000183165"/>
    <dbReference type="OrthoDB" id="10274916at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
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        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALPHATUBULIN"/>
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    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
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        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="57"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="256"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="455" mass="50914" checksum="500FD68BC32C15AC" modified="2019-02-13" version="1">MGGLFCLLQPECISIHVGQAGVQIGNTCWELYCLEHGIQPDGQMPSDKPIGGNNHCSSALFSETEAGKYVPRAIFVDLEPTVIDEVRTGTYRQLFHSKQLISGKEDAANNYARGHYTIGREIIDSVLDRIRKLADQCNGLQGFLVFHSFGGGTGSGFTSLLMERISVEFRKKSKLQLAVSPAPHVSTAVVEPYNSILTAHTTLENSDCVFMVDNEAIYDIYRRNLNIERPSYTNINRLISQIVSSITASLRFDGALNVDLTDFQTNLVPYPRIHFSLAAYAPVISAEKAYHEQLSVAEISNECFEPSNQMLKCDTRQGKYMLCCLLYRGNVASRDINSAIRAIKTKRTIQFVDWLPTNFKMGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKKAFVHWYVGEGMEEGEFLEAREDMATLEKDYEEVAGINSFEDDDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTT9</accession>
    <name>A0A3P9BTT9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Type II GnRH receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTT9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013368"/>
    <dbReference type="Ensembl" id="ENSMZET00005013822.1">
        <property type="protein sequence ID" value="ENSMZEP00005013368.1"/>
        <property type="gene ID" value="ENSMZEG00005010048.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278263"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Gonadotropin-releasing hormone II receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001658">
        <property type="entry name" value="GphnRH_fam_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF183">
        <property type="entry name" value="GONADOTROPIN RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00529">
        <property type="entry name" value="GNADOTRPHINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="367" mass="41948" checksum="665473FE79BB129E" modified="2019-02-13" version="1">MAGNWSILRLSLPPTNWEAPSFTRAAQFRVGATFVLFLFAACSNLALLVSVWRGQRLASHLRPLMLSLASADLMMTFVVMPLDAVWNMTVQWYGGDALCKLLCFLKLFAMHASAFILVVISLDRQHAILHPLDALSAHSRNRRMLLLAWTLSILLASPQLFIFRTIRVDSVDFTQCASHGSFSRRWQETVYNMFHFTTLYVVPLLVMSCCYSRILLHIHQQHLRDKAGESPLRRSGTDIIPKARMKTLKMTVVIVLSFVVCWTPYYLLGIWYWFQPDMLRITPEYVHHALFVFGNLNTCCDPIIYGFYTPSFRADLAACCRWVRSDADTSSQYIDRMSTREGPHSREHEPQPSTNNQTNNAVILSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXH8</accession>
    <name>A0A3P9BXH8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tandem C2 domains, nuclear</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540020.1">
        <property type="nucleotide sequence ID" value="XM_004539963.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXH8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014693"/>
    <dbReference type="Ensembl" id="ENSMZET00005015178.1">
        <property type="protein sequence ID" value="ENSMZEP00005014693.1"/>
        <property type="gene ID" value="ENSMZEG00005011063.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478533"/>
    <dbReference type="KEGG" id="mze:101478533"/>
    <dbReference type="CTD" id="123036"/>
    <dbReference type="GeneTree" id="ENSGT00390000009196"/>
    <dbReference type="OrthoDB" id="9936710at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030542">
        <property type="entry name" value="Tac2-N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46887">
        <property type="entry name" value="TANDEM C2 DOMAINS NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46887:SF1">
        <property type="entry name" value="TANDEM C2 DOMAINS NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="311"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="456" mass="51341" checksum="DAE212B2CB5A0633" modified="2019-02-13" version="1">MECIKNCCKNFMKKNEQERETQVIALKMPPNTAAAPGPNVSEDYLLSKMPPDGREVPFVVPTYVQPSYPNLQAEPQSSARCTYAARKAELVSTTPFIYYPESFFHQGHMAEHISPGSSRRDTMKKRSFGPQSPGWNMKLGGQERLSSSMFDLSNPQGHMQRFESLSSASSKMSSMTSSLESVTLSGDERELGKVCVRLNYQEALEQVWITLVQCSDLNLHPDGGEQQMIGFKSIITTPKPIQFKSSVREYCQDVSFMETFVFALHLQLLRCSALVLRLQTHNPKKRTVAECVLSLRHLGSQETEHWLELNPPSKSSVCHSELHLTTCFQPVNGRIQVQVLAAQNLPVSSSPLTQAFFVKVEMTQLEEVTKKKTRVLKASGGQCQWAETFHFHLATLDHAYSLSVKLYSRSSVRRKQYLGQIQLGLNSPIPEAVEQWKDTMAHPEKVVAAWHRLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXW3</accession>
    <name>A0A3P9BXW3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dynein axonemal intermediate chain 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">WD repeat-containing protein 78</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXW3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014828"/>
    <dbReference type="Ensembl" id="ENSMZET00005015316.1">
        <property type="protein sequence ID" value="ENSMZEP00005014828.1"/>
        <property type="gene ID" value="ENSMZEG00005011154.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156209"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF12">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="660" mass="73808" checksum="1582BFB06EF41CEF" modified="2019-02-13" version="1">DEVNNDVTPQPLYQADPGAVQPMLFVDEMSLMQTKWFFQSPHITVTKALSSRSHLQRIFVVFIRVCSYIFLLDVKVKKDTEKEQVTEDMLKDITEVFISETDTFSLLDMPSTFVCVDADEAEATMWVKSRNHQYEEVCRNRVSRDKHVERSVQTLTGTTKNKHVQSNGLMVDGVLSFYKCTVFSDVCMSTATNVTVCDMYEPLSEAEQEETAGICNPVKTDHSEGVTDSKTVFLYLSSVSACGSLKEVEVKALNAETQWKLIMLSDKFQLCLQTVERSILQNSFHPQLAAYRQLPVLGDPECPVKNEMVEQRTGGMDGGPSLQCLWVFSCELSRGRSVSCMTWNRKNPDLLAVGHGKFDSGNQKPGLVSCWSIKNLKWPEHVIHCDSAVTALDFSANSPSQLAVGTHDGSITIHSVHSQDNSPNRHLGPVWQLRWTQQQVSSTGEEKVEALLSVGADGRISKWFFFKDGLDCIDLMKLSVLTALTPGLCFDFHPTDSSIYLTGTWEGLIHQCSCSNSQQFLETYRKHFCPVNCVAWSPFNPDVFLSCSSDWTIQLWKQHHLKPVLGFTSAQKAVYDIKWSPKWPTVFGAVTEGQLEIWDLSSSILDPVIVQPAAPGVRMTSLLFSSQADCVVVGDTDGHVTVYQLKNLSVGEQSQVTLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY52</accession>
    <name>A0A3P9BY52_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">E3 ubiquitin-protein ligase MARCHF2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Membrane-associated RING finger protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Membrane-associated RING-CH protein II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">RING-type E3 ubiquitin transferase MARCHF2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004554926.1">
        <property type="nucleotide sequence ID" value="XM_004554869.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BY52"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014571"/>
    <dbReference type="Ensembl" id="ENSMZET00005015054.1">
        <property type="protein sequence ID" value="ENSMZEP00005014571.1"/>
        <property type="gene ID" value="ENSMZEG00005010963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479905"/>
    <dbReference type="KEGG" id="mze:101479905"/>
    <dbReference type="CTD" id="51257"/>
    <dbReference type="GeneTree" id="ENSGT00940000158995"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16808">
        <property type="entry name" value="RING_CH-C4HC3_MARCH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000119">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="26">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="25">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040156"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042437"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043183"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="253" mass="27995" checksum="41DB0F5FC5A14633" modified="2019-02-13" version="1">MDPVTMTTGGCCHLPGSLCDCASNTGLWKSVEEAGGDGCQALYVTQVTAIDGRLLSSVLKPMSAQSDGPICRICHEGGSSEGLLSPCDCTGTLGTVHKSCLEKWLSSSNTSYCELCHTEFSIERRPRPLTEWLRDPGPRNEKRTLFCDMVCFLFITPLAAISGWLCLRGAQDHLQLRSWLQAVGLIALTIALFTIYVLWTLVSFRYHCQLYSEWRRTNQKVRLLIPEAKESNSSQHSLLSNKLMKKSASESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYM6</accession>
    <name>A0A3P9BYM6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Toll like receptor 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYM6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014967"/>
    <dbReference type="Ensembl" id="ENSMZET00005015455.1">
        <property type="protein sequence ID" value="ENSMZEP00005014967.1"/>
        <property type="gene ID" value="ENSMZEG00005011242.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156323"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042497">
        <property type="term" value="F:triacyl lipopeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF17">
        <property type="entry name" value="TOLL-LIKE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018311226" evidence="15">
        <location>
            <begin position="25"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="16">
        <location>
            <begin position="535"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="672" mass="75415" checksum="236528E491089544" modified="2019-02-13" version="1">IRLLVTHKSIIFLVFVLLVSQCSALTSQQCHHCEQTSCDCSSQNLREVPAAASKLITELDLSLNALETIMKDDFLSYAALRALFVNNNRIKTIHEDAFHPLTHLEKLDLSSNQLETLSSGWFQNLTSLHYLNLLGNKYSTLGQGNLFLPLRSLKTLHFGGPFLQSVSKRDFSGLFGLEELVFEGNHLQVFNRGSLRQIGPISHVTLSLNGVFHRDLAVVRAILLDVVHPNTTVTFTDTQFNKSLQMFPLHVAIERGATGLSFKNVNMSVSACVQLVNIFSGSDLTFFAIEDSHIFKNEEEVRLHHINLTSLDVIVFKNIDINVFYRVPELHFMQNILTVVRRASMINTMLFVIPCQSTIHFSDLEFLDISDNIIGDLTLMEMMCYGIGVLLNLRTLNISKNILSSINSKLFTRLEKLENLDMSRNSFDSMPSTCSWPASLKFLNLSSTSLPEVTSCLPQSLQILDLSRNKLTVFSIELPLLKELYISGNKLGNLPDGHLYVSLAVLSIQDNNLAKFSSKNLHDYQSLRVLEAAGNPYVCSCDFVGFVTNDLMNHKTVVRHDLKSYICDSPDAVRGERVSDVKLSVFECHTALAISLLCLGILVLCVLIAGLCYKFSVVGLNEGDNFVKIRLRKAMNSRTYLESPHDEDHIPAFWQSLRTAMKTSEIDNKDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZN0</accession>
    <name>A0A3P9BZN0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="RefSeq" id="XP_004559681.1">
        <property type="nucleotide sequence ID" value="XM_004559624.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZN0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015364"/>
    <dbReference type="Ensembl" id="ENSMZET00005015861.1">
        <property type="protein sequence ID" value="ENSMZEP00005015364.1"/>
        <property type="gene ID" value="ENSMZEG00005011531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474325"/>
    <dbReference type="KEGG" id="mze:101474325"/>
    <dbReference type="CTD" id="8879"/>
    <dbReference type="GeneTree" id="ENSGT00390000000046"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000247">
        <property type="entry name" value="Sphingosine phosphate lyase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000001">
        <property type="entry name" value="Sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="565" mass="62504" checksum="4CDB671C50B5B03F" modified="2019-02-13" version="1">MDYWSALEVYKEMVLLYLEEGRQQVNSRCAHLEPWQIIGVTVITTVGALWVKGFLFQQESLTSRIKKQCFRLIRKIPFIGGAIQSQLNKALDDMSASLFTLKEGMSYTTELPSKGLSQAKVMEKIKEYDTLNEVKWDKGLVSGAVYWGDESLTNLLVKVYGDFAWSNPLHPDIFPGVRKMEAEVVRMACTLFHGGPNSCGTVTSGGTESILMACKAYRDIAHERGVKHPEILAPVSVHAAFDKAAHYFGMKLVHIPLDKKTMKVDVKAMRRAISKNTAMLVCSAPQFPHGIIDPIEEVAKLAVRYNIPMHVDACLGGFLIVFMAKAGYPLAPFDFRVKGVTSISADTHKYGYAPKGSSVILYSDKKYRQYQYFVAADWQGGIYASPSIAGSRPGGIIAACWATMMYMGENGYVDATKKIVSTAHKIKTEIRKIKGVFVFGDPEVSVVAIGSDDFDIFRLSNALTSKGWNLNTLQYPSSIHICCTVLHTQPGVADHFIRDVKEQVAIIMKNPKEKTTGMGAIYGMAQAIPDRSLVTEISRGFLDCLYSTEVTKSNISHMNGNGKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2A5</accession>
    <name>A0A3P9C2A5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">CSN12-like protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2A5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016247"/>
    <dbReference type="Ensembl" id="ENSMZET00005016764.1">
        <property type="protein sequence ID" value="ENSMZEP00005016247.1"/>
        <property type="gene ID" value="ENSMZEG00005012199.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001101"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000146">
        <property type="entry name" value="PCI domain-containing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="188"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="377" mass="43455" checksum="9470A7B9035A2F14" modified="2019-02-13" version="1">TRPSTTVRAPSVLSCCPSNTRMLPIPLASPEDKCQQVLEPPYDEMVAAHLRCTYAVANHDFVEAYKFQTLVAFQSHKEENWALPVMFAVTLDLRIFANNAEQQLQKKGKGQPSEMLEKAAEQLMSCFRVCASDNRAGIEDSKKWGMMFLSNQLFKIYFKINKLHLCKPLIRAIDSSNLKNDYSPAQKVTYKYYVGRKAMFDSDFKLAEEFLSYAFDHCHRSSQKNKRMILIYLLPVKMLLGHMPTHQLLRKYDLMQFSDVTKAVSEGNLLLLNEALSKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLRTHQLPLEAFLVALRMMKVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPFPPLSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3V3</accession>
    <name>A0A3P9C3V3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="10">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C12 family. BAP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3V3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016724"/>
    <dbReference type="Ensembl" id="ENSMZET00005017258.1">
        <property type="protein sequence ID" value="ENSMZEP00005016724.1"/>
        <property type="gene ID" value="ENSMZEG00005012560.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156388"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904888">
        <property type="term" value="P:cranial skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000002">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF28">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="336"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="637" mass="70991" checksum="814F6BCC02AD2FA0" modified="2019-02-13" version="1">MNKGWLELESDPGVKGVQVEEIYDLQSKCQSPVYGFIFLFKWIEERRSRRKVNTLVDETSVIDEEIVNDMFFAHQLIPNSCATHALLSVLLNCSGVELGTTLSRMKAFTKGFSPESKGYAIGNAPELARAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVSYVPIKDRLFELDGLKAYPIDHGPWGEEEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRMKYESKLEILKRNRQTVLEGLQKMIRLTQPELVHDKKQQGSSSPDESSVTVKKEVDADPVTSQGGEHASSGKAVVPTGGGSQQVTSSNPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRMPGPPQPPYSDDEDDYDEEEEEMTGSASLRSRTGRVATGMESQIALSVLAEKLKKEAQRKDALNTPLSVRTEGRTGGICITSASQPSPTPSNESTDTASEIGSAFNSPLRSPARSQAATRPSSPVASHLSRVLFGEDEMLRLDSRHNRAVRELGPSVSVALLHLQEDGTIYTLPPSGVKGGDEGPSAEELLALLKCVEADIANYEVHLKEEVEKRKKYKIDDQRRTHNYDEFICTFISMLAQEGMLASLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3W9</accession>
    <name>A0A3P9C3W9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucocorticoid modulatory element binding protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004564460.1">
        <property type="nucleotide sequence ID" value="XM_004564403.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3W9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016591"/>
    <dbReference type="Ensembl" id="ENSMZET00005017123.1">
        <property type="protein sequence ID" value="ENSMZEP00005016591.1"/>
        <property type="gene ID" value="ENSMZEG00005012463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479005"/>
    <dbReference type="KEGG" id="mze:101479005"/>
    <dbReference type="CTD" id="10691"/>
    <dbReference type="GeneTree" id="ENSGT00410000025596"/>
    <dbReference type="OrthoDB" id="5792412at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.390.10:FF:000003">
        <property type="entry name" value="glucocorticoid modulatory element-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059099">
        <property type="entry name" value="GMEB1/2/Spe-44_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000770">
        <property type="entry name" value="SAND_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417:SF3">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25892">
        <property type="entry name" value="Spe-44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAND" evidence="11">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="608" mass="65609" checksum="E884584A7F28D7BC" modified="2019-02-13" version="1">MSVMATTDEVTVPMGEVVMVKDDSGEGDPDDPNKTQVILQLQPITTGDESAETDAAVMAVESHSEQTEGDDVEIGCPITCGDCKAVLLVKKFVCPGINVKCVKYEDQLISPKQFVHISGKATLKDWKRAIRMGGVMLRKMMDSGQLDFYQHSTLCTNTCRSTKFDLLINNTRFPPDGTGLTTPTSSQVTGQVILGNGGAAAEDRAKVLSGKLDWSSSSSESADKKGSAEISEDTLNFWKGIADVGLLGEVVTNINTELVELLNSVQQRMDPASLQDTDSCLVEVAVLSNLAQVFDLLDVVKKIVERRKQQTDPSQEQVLSMLTNLEVQLEEQKKQQQVRALLTCPQPAKNKTPTKRPTKRPRLQRPASTTTLLTTPINQQATLQPQQFTVLSPISLSSVGQPFTVAGLPIASLSQSSNTVTLLPAGSQVFTRYMVAGDGKTETITLHPSSGLTLVGTTALQDSSQLGTVMSPMELVQLSQQASGAEVVPIEGQVVDGTMLVQQEVMQGEVEGSQEHTVIEINPTPVEQAVGVMELQLTGESGREGATMVVQSGVEMTMSAETEEETQHQLQEAHTERVQEVQLDASGHLSHVQIVVIGENTQEENKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C415</accession>
    <name>A0A3P9C415_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tumor protein p53 inducible protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540133.1">
        <property type="nucleotide sequence ID" value="XM_004540076.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C415"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016852"/>
    <dbReference type="Ensembl" id="ENSMZET00005017390.1">
        <property type="protein sequence ID" value="ENSMZEP00005016852.1"/>
        <property type="gene ID" value="ENSMZEG00005012652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482644"/>
    <dbReference type="KEGG" id="mze:101482644"/>
    <dbReference type="CTD" id="9540"/>
    <dbReference type="GeneTree" id="ENSGT00940000161217"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="40"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="367" mass="39703" checksum="8E5366F96FBEC24C" modified="2019-02-13" version="1">MHPILQPGRFLLRNTCHTVWSKHYVSVAKMMRAVCVDVPGGPENLLLQSVPRPNPKAGEVLIKVHAAALNRADLLQRRGLYPPPAGESDIIGLEVAGTIHTLGPGVKKQWKPDDRVMALLCGGGYAEYVSVPEELLMPVPSNLTMCQAAAIPEAWLTAFQLLDFVAQVKEGEVVLVHAGGSGVGTAAVQLVRLFRGVPVVTAGSPEKLKLAEKLGAVVGFNYKEESFAQGVHDFTGGKGANVILDCIGGRNWESNVSSLAIDGRWVLYGTMGGRAVEGDLLGKLLSKRGHLLTSLLRSRSLQYKADLVKAFTGRVLPYFSDQPATLRPVIDRTFSLDDIAEAHKHMEANRNMGKIVINVIPQIEQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6H3</accession>
    <name>A0A3P9C6H3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FAM104A</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C6H3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017707"/>
    <dbReference type="Ensembl" id="ENSMZET00005018273.1">
        <property type="protein sequence ID" value="ENSMZEP00005017707.1"/>
        <property type="gene ID" value="ENSMZEG00005013316.1"/>
    </dbReference>
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        <property type="component" value="LG4"/>
    </dbReference>
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        <property type="entry name" value="VCF1/2-like"/>
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    <dbReference type="PANTHER" id="PTHR34763">
        <property type="entry name" value="PROTEIN FAM104A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34763:SF1">
        <property type="entry name" value="PROTEIN FAM104A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15434">
        <property type="entry name" value="FAM104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="119" mass="13021" checksum="9DB167FB98F5CB7F" modified="2019-02-13" version="1">ILAFYLNRKRQHSGGDEENGHLVPQAKRQTRAHPISPEPGRDAWDSEVQSSNSESSSSISSPERAAGSCVSQCAQGPCSPLSVGNSFEPTNPVSYLHINRILKDAHFQSLQNRGHLRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C859</accession>
    <name>A0A3P9C859_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAM domain, SH3 domain and nuclear localisation signals 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C859"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018249"/>
    <dbReference type="Ensembl" id="ENSMZET00005018840.1">
        <property type="protein sequence ID" value="ENSMZEP00005018249.1"/>
        <property type="gene ID" value="ENSMZEG00005013704.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157806"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="CDD" id="cd11822">
        <property type="entry name" value="SH3_SASH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021090">
        <property type="entry name" value="SPIDER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF4">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN SAMSN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12485">
        <property type="entry name" value="SPIDER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="352"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="432"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
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        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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            <dbReference type="PROSITE" id="PS50105"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="547" mass="60991" checksum="F8040DB460E42537" modified="2019-02-13" version="1">MRKTKHRTETRGGKGSHHSGTKKKEKQTSSQSVHANGVATESKAAVRRNPKNSKKAGGKSGKEGTKKANSSRVCSPPGMMSPQMGHHFPEVPYRSDRRPYPGKFSTLPSQENTTPGRCTDMASLPGGATPTHHQRWSNPADSSLAWGTVQHTCRRPLTEYRVYSHDFITAHVKEWEGRQEHRQVVAQDGCLKQDCKPEIPPRVPRSITDVDLSEPNRSTSFGKFEGLRHHSSQAKPKENGTAMVTEECESSDPNNSAGLRKKMKEISLTMRRKMGKKHAKSLSEETGDDTDKEPDAETESSPPAEKNSTQTSNSLESLYSGQSSSSGVTSESNGSGQRDSLRLEEDGSYHGQFCGRARVHTDFVPSPYDTDSLKLKVGDIINIISKPPMGIWTGMLNNKVGNFKFIYVDVLVEKEEEEETPKIRQQKLCKRPRPKTLLELLERLNLEEYASALMLNGYETVESLMHLQEKHLIELNVKDPEHRQKLLTAAEYHYTEGDDVRDAEELKSSHSLQEEDSDCPRDSGCFIPSECSDSKEDTEPVTDAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C884</accession>
    <name>A0A3P9C884_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NIF3-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer. Interacts with COPS2. Interacts with THOC7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574670.2">
        <property type="nucleotide sequence ID" value="XM_004574613.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004574672.2">
        <property type="nucleotide sequence ID" value="XM_004574615.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C884"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018292"/>
    <dbReference type="Ensembl" id="ENSMZET00005018883.1">
        <property type="protein sequence ID" value="ENSMZEP00005018292.1"/>
        <property type="gene ID" value="ENSMZEG00005013736.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101486698"/>
    <dbReference type="CTD" id="60491"/>
    <dbReference type="GeneTree" id="ENSGT00390000003590"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000004">
        <property type="entry name" value="NIF3-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017222">
        <property type="entry name" value="DUF34/NIF3_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037490">
        <property type="entry name" value="UCP037490_NIF3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="424" mass="45673" checksum="6BAF57F2FF6B3177" modified="2019-02-13" version="1">MLTGCRNLAWRFFSLTSRRLWTRQSFKSRAALCSSAFSSVLHSLPSSTHSHHILPSRQSSARLPPSVNFSSVHSSGLMELKEVLQVLEQLAPLSLAESWDNVGLLVEPSKPRPVKTILLTNDLTDAVMEEAVAVSCDLIISYHPPLFRPIKRLVQKDWKQRLAVRAVEVGIAVFSPHTSWDCVKGGVNDWLVGGLGSGQVSVLSQILGAASHSHKLEFTVRSAEELNMIMEELKACDSGTTLQHSGSRPDSSGIHVSVTCCDSALTPSVQALLGHGTPSQSLTIVKLEKPPLLGHGQGRCSVLDQPVTVGAAVQKLKSHLGLSHLRLALGWGQTLESSVYTVAVCAGSGVSVLNGVKADLYVTGEMSHHEVLDAVAKGTSVILSDHSNSERGYLAVFRERLAMRLPDSVTVVLSKADRDPLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8K7</accession>
    <name>A0A3P9C8K7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipase</fullName>
            <ecNumber evidence="19">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with PIP5K1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Lipid-anchor</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="19"/>
    <dbReference type="RefSeq" id="XP_004540225.1">
        <property type="nucleotide sequence ID" value="XM_004540168.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8K7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018615"/>
    <dbReference type="Ensembl" id="ENSMZET00005019215.1">
        <property type="protein sequence ID" value="ENSMZEP00005018615.1"/>
        <property type="gene ID" value="ENSMZEG00005013951.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480431"/>
    <dbReference type="KEGG" id="mze:101480431"/>
    <dbReference type="CTD" id="556641"/>
    <dbReference type="GeneTree" id="ENSGT00940000155015"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032534">
        <property type="term" value="P:regulation of microvillus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000114">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000021">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000005">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000009">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000018">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF57">
        <property type="entry name" value="PHOSPHOLIPASE D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 19" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="23">
        <location>
            <begin position="102"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="21">
        <location>
            <begin position="242"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="22">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="22">
        <location>
            <begin position="873"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="521"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1056" mass="121125" checksum="90885FBB2EC0FCBD" modified="2019-02-13" version="1">MRSKAQTATSNLNLVNSVDSDSRAAQDIHDGIKMADLVESLDTRELDIGEGEDVDYDGNNIGDCRIPFSAVYATVGFKEANAKVYLPTVPITARILEVERFTTAQDRFNASHQRSVNKSLPAVFKIELKHGEFTWVVKRKEKHFMELHRELRTYKTFMRIPLPSRSHTVRRKTVRKSEVREMPSLPRGGGEELVRDEQVSSRKRQLEDYLNKLLRMAMYRKYHHTMEFIDVSQMSFIHDLGPKGLEGMIYKRSGGHRIPGMNCCGQSQACYRWSKRWLVVKDSFLLYMKPDTGAISFVLLVDKEFTIKMDSKDTETKHGVRIDSLSRTLVFKCSSYRHARWWGQSIESFVRNHGKAFLRDHRFGSFAQEQENIPAKWYVNGKTYMEDVADALEEAKEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFVMLYKEVELALGINSGYSKRTLLHLNPNIKVMRHPDHVSSSVYLWAHHEKIVVIDQSVAFVGGIDLAYGRWDDREHRLTDVGSVTRSDESRLRKTGSTNTPSSKGLSSVDGVSQSNGRGTPPSDPADLPKLKGIGRNRMARFSLRTLRHKHTLQHVDSVSSVDSAGSGSVRSLKTGVGELQGNTRFWHGKDYCNFVYKDWIQLEKPFDDFIDRYTTSRMPWHDIASVVHGRAARDVARHFIQRWNFTKIMKPKYRSLSYPFLLPKSHSTTNELRYQVPECVNAKVQVLRSSADWSAGIKYHEESIHNAYIQVIAKSKHYIYIENQFFISCADNRTVYNKIGDAIIERIIRADKERKKYRVYVVTPLLPGFEGDITTGGGNAIQAVMHFNYRTMIRGEYSIISQLKKEMGDQWMNYISFAGLRTHAELAGRLVTELIYVHSKMLIADDNTVIIGSANINDRSMLGKRDSEVAVIVEDSEKVPSVMDGEEYEAGHYALQLRLECFRTILGGHSDTSIDLSDPISDRFYKEVWMTTAGRNATIYEKVFRCLPSSLVRNMSELEQYQSKPGLAQTDLARAQEELRKIRGFLVQFPLDFLSEQNLMPSVGTKEAMVPTEIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9M3</accession>
    <name>A0A3P9C9M3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neurogenic locus notch homolog protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="38 39">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="38 39" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="38" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="38" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Late endosome membrane</location>
            <topology evidence="28">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOTCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004566803.2">
        <property type="nucleotide sequence ID" value="XM_004566746.5"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005018744"/>
    <dbReference type="Ensembl" id="ENSMZET00005019346.1">
        <property type="protein sequence ID" value="ENSMZEP00005018744.1"/>
        <property type="gene ID" value="ENSMZEG00005014036.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101473768"/>
    <dbReference type="CTD" id="794892"/>
    <dbReference type="GeneTree" id="ENSGT00940000157157"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031017">
        <property type="term" value="P:exocrine pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060218">
        <property type="term" value="P:hematopoietic stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF17</accession>
    <name>A0A3P9CF17_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BPTI/Kunitz inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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            <taxon>African cichlids</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A3P9CFQ7</accession>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSMZET00005021666.1">
        <property type="protein sequence ID" value="ENSMZEP00005020977.1"/>
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        <property type="entry name" value="Immunoglobulin kappa constant"/>
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        <property type="entry name" value="Immunoglobulin kappa variable 8-16"/>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="Ig_C1-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHH8</accession>
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        <submittedName>
            <fullName evidence="11">Ankyrin repeat domain 13A</fullName>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004544610.1">
        <property type="nucleotide sequence ID" value="XM_004544553.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHH8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021484"/>
    <dbReference type="Ensembl" id="ENSMZET00005022193.1">
        <property type="protein sequence ID" value="ENSMZEP00005021484.1"/>
        <property type="gene ID" value="ENSMZEG00005016134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482664"/>
    <dbReference type="KEGG" id="mze:101482664"/>
    <dbReference type="CTD" id="88455"/>
    <dbReference type="GeneTree" id="ENSGT00950000182928"/>
    <dbReference type="OrthoDB" id="1585644at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140036">
        <property type="term" value="F:ubiquitin-modified protein reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002091">
        <property type="term" value="P:negative regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000057">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF4">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="10">
        <location>
            <begin position="161"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="600" mass="67818" checksum="A062690E95151E71" modified="2019-02-13" version="1">MSMANISEDIRVKFPLHSAVWENDYRKLEQLLTSTQNDIEAVDPRGRTPLHLAVSLGHLESVRILLRHGGQVTKENANNWTVLQEAVSTGDPEMVQLVLQRRDYLKASTALGGVPELLSKIRVSPDFYMEMKWEFTSWIPLVSRVCPSDVCRIWKSGASLRVDVTLLGFENMTWIRGRRSYIFRGDDSFAELMEVNHDDEVVDIERFNISQEMEDVTLESMQPAEQEVAKRLTTPIVNTYLDTKDIAFERTKSGIWGWRADKTEVVNGFEAKVFSVNNVNVVIRTRTEHLTDEEKARIKSERNILESLLGTVEQHINAQGDLTLEYATANNPTAITPEEYFDPDFDLVKRDIGRPIELSIRTQKFKGTLWMSEDHPLSLVEQVTPIIDLMARTSSHFARLRDFVTLKFPPGFPVKIEIPLFHVLNAKITFGSVNKCSTEEEANTSAAATPTSTGDDEAAAPPPFQVCPSVFEVPASYHRRGGSRHMPVSNNDEELLQYAIHQSLLESRQGTGQEGLWDHVDGDFADVMPINQSDRSIPEGVLVDYRDTSSPPSSASASSPDSDLRLAMELSARAQEEEERMRKQEEEELERILQLSLTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHU2</accession>
    <name>A0A3P9CHU2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FXYD domain-containing ion transport regulator</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FXYD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHU2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021604"/>
    <dbReference type="Ensembl" id="ENSMZET00005022314.1">
        <property type="protein sequence ID" value="ENSMZEP00005021604.1"/>
        <property type="gene ID" value="ENSMZEG00005016217.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176207"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043269">
        <property type="term" value="P:regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20330">
        <property type="entry name" value="FXYD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.780:FF:000009">
        <property type="entry name" value="FXYD domain-containing ion transport regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.780">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000272">
        <property type="entry name" value="Ion-transport_regulator_FXYD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14132:SF14">
        <property type="entry name" value="FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14132">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02038">
        <property type="entry name" value="ATP1G1_PLM_MAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="61" mass="6742" checksum="3047F0B71C5DFC1D" modified="2019-02-13" version="1">MSSPKGADVDLDADFVYDYEKLRIGGLIFAGVIVFLSIILLAGNKIRNCGKSKVRYCWMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CM53</accession>
    <name>A0A3P9CM53_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="15">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_004538331.1">
        <property type="nucleotide sequence ID" value="XM_004538274.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004538332.1">
        <property type="nucleotide sequence ID" value="XM_004538275.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004538333.1">
        <property type="nucleotide sequence ID" value="XM_004538276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CM53"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023121"/>
    <dbReference type="Ensembl" id="ENSMZET00005023873.1">
        <property type="protein sequence ID" value="ENSMZEP00005023114.1"/>
        <property type="gene ID" value="ENSMZEG00005017316.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005023880.1">
        <property type="protein sequence ID" value="ENSMZEP00005023121.1"/>
        <property type="gene ID" value="ENSMZEG00005017316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483509"/>
    <dbReference type="KEGG" id="mze:101483509"/>
    <dbReference type="GeneTree" id="ENSGT00940000165673"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000008">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="PA" evidence="17">
        <location>
            <begin position="666"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="830"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="839"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="857" mass="96166" checksum="339ADE5128C7F439" modified="2019-02-13" version="1">MMQSYMRTTGNKQCWESASASTTGMMWKTLLVVSLFCWGKCQESQNMTPEEKGAIRDQIVEMFDHAYGSYMKYAYPADELMPLSCRGRVRGQEPNRGDIDDSLGKFSLTLIDTLDTLVVLNKLDEFEEAVKKAVSDVRLDNDVVVSVFETNIRVLGGLLGGHVMADLLRQRGERMQWYRDELLHMAKELGHRLLPAFNTTSGLPYPKVNLRYGVLNPLSRTGTESDTCTACAGTMILEFAALSRLSGNSVFEEHARKALDVLWERRQRGSDLVGTVINIHNGEWVRRDSGVGAGIDSYYEYLMKAYILLGDNVFLDRFNVHYSAIMKYISQPPLLLNVHMHNPTVSVRSWMDSLLAFFPGLQVLRGDLKPAIETHEMLYQVTKQHKFLPEAFTTEFRVHWGQHLLRPEFAESTYYLYKATGDPYYLRVGQSIVEKLNAYARVPCGFAAVQDVRTGTHEDRMDSFFLAEMFKYLYLMFSEKSHLPIDMDGYIFTTEAHLLPISLSTTQPPCPGNDTETVRISQEEDLFTHSCPSTETLFPNNPSFAKTIRDGYKYLTGVGRAFHPLPIREIELPLHDNGMEPVEFFKSMGISLTPLNEANMGDTGRLKEHKGVYRVKLVAELSQAPEEEVVVPHVVQLISPPFLGRTVLTAGPAKFGMDLTKQEHGVKGSIVKASPYTACGPIDNAAGLKGHIALALRGDCMFAAKARWLQKAGAIGAIFIDHREGSNSEETPLFQMVGDGDSTEDITLPLVFLFSREGAVLTAALEKHHNVDVLLLPKERQLGRDKMEKHVSMNLKLRLAEEGEMEGGAASGRTLEFVLENDEVLLKDEGVEELREKQQQSCTEDSDRTQPSQIPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CN94</accession>
    <name>A0A3P9CN94_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Four-jointed box kinase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CN94"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023562"/>
    <dbReference type="Ensembl" id="ENSMZET00005024336.1">
        <property type="protein sequence ID" value="ENSMZEP00005023562.1"/>
        <property type="gene ID" value="ENSMZEG00005017634.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016768"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024868">
        <property type="entry name" value="FJX1/FJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13147">
        <property type="entry name" value="FOUR-JOINTED BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13147:SF5">
        <property type="entry name" value="FOUR-JOINTED BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02072">
        <property type="entry name" value="4JOINTEDBOX1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018008337" evidence="2">
        <location>
            <begin position="19"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="427" mass="48738" checksum="7F9D5F107B0B571D" modified="2019-02-13" version="1">MRVLSANLFSLLLLCALASVFYVWSALEDRLERHKRRFSVPGAGSFHQALPVDLSAKTFRALLAVPAAQRLHFGDRLKTRLNLTNQPVSAGNRDYNMNGDNKRSAPREGPVKLSPLEDGIFWNEWLEDTLPAGFTEEYALAWQKKARTYRVVKLEPGCGRISNQLATFADGTKACVRYGINADQVQGETLTYYLARLLGITNLPPLVLSQLDSDSEQWESVRTRIDGLQWNDRAVVSLTQWISNLTGVITPAPLRQESSGLHPALKELWNKTAVELLELMQWTDLIVLDYLTANFDRLVSNLFSLQWDSRVMERDTNNLLKTPRGDLVFIDNEAGLVHGFRVLNMWEKYHNTVLSSVCVFRKRTTQRVAELHTRRDSRQRLLELYRDSEPLSQELGFLSDEHAGVLQDRIDRLYTHIVHCKGKYGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNP7</accession>
    <name>A0A3P9CNP7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V(D)J recombination-activating protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In the RAG complex, rag2 is not the catalytic component but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor of chromatin state that recruits the RAG complex to H3K4me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the RAG complex composed of core components rag1 and rag2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAG2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563472.2">
        <property type="nucleotide sequence ID" value="XM_004563415.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CNP7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023664"/>
    <dbReference type="Ensembl" id="ENSMZET00005024441.1">
        <property type="protein sequence ID" value="ENSMZEP00005023664.1"/>
        <property type="gene ID" value="ENSMZEG00005017702.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101481301"/>
    <dbReference type="CTD" id="5897"/>
    <dbReference type="GeneTree" id="ENSGT00390000012559"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097519">
        <property type="term" value="C:DNA recombinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905347">
        <property type="term" value="C:endodeoxyribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990238">
        <property type="term" value="F:double-stranded DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033152">
        <property type="term" value="P:immunoglobulin V(D)J recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065004">
        <property type="term" value="P:protein-DNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030217">
        <property type="term" value="P:T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000047">
        <property type="entry name" value="V(D)J recombination-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.290">
        <property type="entry name" value="Rag2 PHD finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004321">
        <property type="entry name" value="RAG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025162">
        <property type="entry name" value="RAG2_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10960">
        <property type="entry name" value="V D J RECOMBINATION-ACTIVATING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10960:SF0">
        <property type="entry name" value="V(D)J RECOMBINATION-ACTIVATING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03089">
        <property type="entry name" value="RAG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13341">
        <property type="entry name" value="RAG2_PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Recombination activating protein 2 PHD" evidence="14">
        <location>
            <begin position="417"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="357"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604321-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="533" mass="59680" checksum="0B92E29530B36539" modified="2019-02-13" version="1">MTLQPLTPVNCAGLLQPGCSLLQLDGEVLLFGQKGWPKRSCPTGVFGVRFKHGEMKLRAISFSNDSCYLPPLRCPAVCRLDPYDGLPESYLIHGGRTPNNEISSSLYLLTMDSRGCNRKLTLCCTEKELVAEVPGPRYGHTMSMVQSRGKTACVLFGGRSYMPSGERTTESWNSVVDCPPQVFLFDLEFGCCSAHTLPELSDGQSFHLALAREDCVYFIGGHSLASDSRPPRLFCLHVELLQGSPLLSCETLDNGLSISSAIFTRTGPTHRYIILGGYQSDSQKRMECTTVILDEKGIHFDPVETPKWTPDIIHSRTWFGGSSGEGGILLAVPTEGRPSQQDMHYFYQVNFQTEGETREEDGTLACSQESTDYDDSTPLEDSEELYFGREPHELDGSSDGEGEAYNEEDEEDESQTGYWIKCCLGCQLDPNTWEPYYSTELHRPAMIFCSRGEGGHWVHAKCMELSETLLLKLSQGNKKYFCLDHGGLPYQEMTPPRHIIPLKRITMKAKDKKRPLTIKMSPAKKSFFRRLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPA9</accession>
    <name>A0A3P9CPA9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004569384.1">
        <property type="nucleotide sequence ID" value="XM_004569327.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPA9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023922"/>
    <dbReference type="Ensembl" id="ENSMZET00005024707.1">
        <property type="protein sequence ID" value="ENSMZEP00005023922.1"/>
        <property type="gene ID" value="ENSMZEG00005017902.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480932"/>
    <dbReference type="KEGG" id="mze:101480932"/>
    <dbReference type="CTD" id="51611"/>
    <dbReference type="GeneTree" id="ENSGT00390000010568"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="288" mass="31799" checksum="62E398CFD9D00E19" modified="2019-02-13" version="1">MLYLIGLGLGDATDITVKGLQAVKSCSRVYLEAYTSILTVGKEALEEYYGKQLILADRDLVEQGADQILEDADVTDVAFLVVGDPFGATTHSDLVLRAVNAGIPYKVIHNASVMNAVGCCGLQLYNFGETVSVVFWTETWRPESFYDKICKNRTAGLHTLCLLDIKVKEQSIENMMRGKKIYEPPRFMTVNQAADQLIQVIQRRKEEGEELGMTEDTVCVGVARLGSDEQKIRVGTLNQLVSCDLGAPLHSLVITGRLHPLEVDMLRVNAEPNALENLHMIDSSTYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPN6</accession>
    <name>A0A3P9CPN6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005017961.1"/>
    </dbReference>
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        <property type="component" value="LG7"/>
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        <property type="entry name" value="DUF4675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="185" mass="21040" checksum="F4818226D9F5226B" modified="2019-02-13" version="1">SDNSAPPFFQFDRQAPGRISTSPTLRRMRSTRRPQIDFREPHRMGSTQEEQSSASTGSPISPLSPGHRVDSPLAASPLSDGEADHQPVSSSGQQRSRSHRSKTFDNSITSVEQECHSAHPFLIKDNGFPEDEVQVSFYHVFVNLVFAYLLRKKTIFHNLHTNLFPITTHKFPVIYCRFFFFFGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CS31</accession>
    <name>A0A3P9CS31_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Protein scribble homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
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        <subcellularLocation>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00072775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1652" mass="182711" checksum="5CA7173FF882B058" modified="2019-02-13" version="1">MLKCIPLWRCNRHVESVDKRHCNLQTVPDEIFRYSRSLEELLLDANQLKELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDISRNDISEIPESIKFCRALEIADFSGNPLSRLPDGFTQLRALAHLALNDVSLQMLPNDIGKSLSFLVKLEQLDLGSNELEVLPDTLGALPNLRELWLDRNQLSSLPPELGNLRRLVCLDVSENRLEELPSELNGLLALTDLLLTQNLLEVVPDSIGSLKQLSILKVDQNRLTHLTDSIGECENLTELVLTENLLQSLPRSLGKLKKLTNLNVDRNRLGSVPKELGGCASLNVLSLRDNRLGKLPAELADATELHVLDVAGNRLQNLPFALTNLNLKAMWLAENQSQPMLKFQTEDDERTGEKVLTCYLLPQQPSPSLENLLQNSVDGSWTDSNLNRVSVIQFQEETKAEVDEDDEAAAERRGLQRRATPHPSELKEMKKGIEERRNEAYTSRQDEDQSLDPQGKRLSDLSNQSHDSQVSNSTLSATSHEDRQNVTEASHMENRVDGPSPQDEDDLDEMEVEYIEPTVHFAEEPIIRGGDEDHEEDGEDGERSDEEDKRPMEKRLIRKDTPHYKKHFKITKLPKPEAVAALLQGFSPDALNSSAQAAEDEEDEEEEQSDGTPQHRHRVEEAEDSRHQVNSSQVKGVSFDQVNNLLIEPARIEEEEHTLTIVRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVKVGDKLLEVNGVDLHEAEHHTAVEALRSSGATVSMTVLRERMVEPENAITTTPLRPEDDYFPRERRSSGLAFNLENSPSGPRQRFSTCLIRNDKGLGFSIAGGKGSTAYRTGDTGIYISRIAEGGAAHKDSTLRVGDRVISINGVDMTEARHDQAVALLTGTSPTIALLVERDLNAPGGSPGQTRARAHSPPPPEPSDSPDQDEESLGNHLSRMEDEYPIEEVTLVKSGGPLGLSIVGGSDHASHPFGINEPGVFISKVIPHGLASQCGLRVGDRILEVNSIDLRHATHQEAVRALLANKQEIRMLVRRDPSPPGMQEIMIQKQPGEKLGISIRGGAKGHAGNPFDPTDEGIFISKVSSTGAAARDGRLQVGMRILEVNNHSLLGMTHTEAVRVLRAVGDSLVMLVCDGFDPGKVAAASPGIIANPFATGIVRKNSMESISSIDRDLSPEEMEIIQKESEMVRETSQWEREEMEKVSIGTGPLKLDYKTLAALPTTSLQKVSRVSFTSCLSDFYFSEFEKKKANIHYTSTPTVKDNPSSSTRPGAIQPVGRVRPSNSPATPDGHSPNPFQHGPSPFNSQTSDLYGTRNNFQPKQPSPESPVFGGKHSPEQRSFRDRQKYFEIDVKQQTPEKPKPRVSLVGEDDLKKMREEEGLKFEQRAREYLLDDDDEDEDEEDLAKQVAQMKATGKVLLDGVEYKVEPVSTPSQHCSTPPNYSSGPSSVDGKGDSQRNSLEDSFRLEQRPNSMTGLVPAYPGESAAPIRTAKAERRHQERLRMQSPELAVAPDKDLSPAEKRALEAEKRAMWRAARMKSLEQDALKAQMVIAKSRDGKKRGTLDQLTESPSPAPTPSPTPMEELSPRGLTSPGRLVRFNPEFHPDVTPLPATSALEEMALYSNKRKLRQGRRSLETAVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CTE1</accession>
    <name>A0A3P9CTE1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable ribonuclease ZC3H12C</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573083.2">
        <property type="nucleotide sequence ID" value="XM_004573026.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CTE1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025645"/>
    <dbReference type="Ensembl" id="ENSMZET00005026478.1">
        <property type="protein sequence ID" value="ENSMZEP00005025645.1"/>
        <property type="gene ID" value="ENSMZEG00005019137.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101468963"/>
    <dbReference type="GeneTree" id="ENSGT00940000155107"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18729">
        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040757">
        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF36">
        <property type="entry name" value="RIBONUCLEASE ZC3H12C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18561">
        <property type="entry name" value="Regnase_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="57"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="465"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="598"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="753"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="820"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="623"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="820"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="904" mass="99920" checksum="8ACCF2A4E65992E9" modified="2019-02-13" version="1">MGLKDHLEDGTGHILSPGLDLDYLHVEGAERQAGNLGAGVTVKSSNTAGSRGISSIIHSSSSSSCSNFSEESAISDSEDERLQTGSGSDSKTPHHDQLHLHQREESSVFQPVRLDLAPNTSPGDPPETSLTDPITHCRTKVEFALKLGYPEELVLLVLRKLGPDALINDILGELVKLGTKIEMDQQGGQAVSQSPSSSLSSTSNSSLDSSRLLCRSHLLEDKENLRPVVVDGSNVAMSHGNKEVFSCQGIKLAVDWFLERGHRDITVFVPAWRKEQSRPDALITDQEILRRLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAYESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLENFLRKRPVIPEHRKQPCPYGKKCTYGHKCKFYHPERGSQPQRAVADELRASAKISSVASRGLLEHALMAKSQKNGQSEGMAEAPLIRDTGKKQPNRSLQSSFSELSEDKTQVSSKVEEQRRNSSLSGSCSNNIVAHPAPGGPPSSGHLERWEHPAGSTGCSSGIAGASGPNKAESYYRCSSPVVGYNSVVKAYSGLSLIVPQTPECFFPGELGTSSLASDCSSESSVSSDSFSPDPVLDDSPKCHHHHPHHHHHHHHYSGQYPHQASRVSPSLSQHSPRGYVHPQGLWRQRDFGIEDTPASVASRISPHHVNTASDYIQPQQQLQLLANFPGEPPHPQHPPQTPTTHARSQSFPRGHNMVGSLWPEHGLQDRVCEGSSVHSRRNYSVRTQQPQHQQNWDPNYEPPPKPYYDLFSYKSFPQVHGHSPWGQQVHSSPHGLLIPGLPSLSQQSLPSVPTHKSHMPSATQHAKPTALGRYQDLRERVFVNLCGIFPPDLVRMVMTRNPHVTDAQELAAAILMEKSQHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVH4</accession>
    <name>A0A3P9CVH4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005026385"/>
    <dbReference type="Ensembl" id="ENSMZET00005027238.1">
        <property type="protein sequence ID" value="ENSMZEP00005026385.1"/>
        <property type="gene ID" value="ENSMZEG00005019678.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163043"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000016">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="10">
        <location>
            <begin position="4"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="11">
        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="9">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="10">
        <location>
            <begin position="692"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1289" mass="147438" checksum="567685CF412E9B7E" modified="2019-02-13" version="1">MHLQDMNEIANFKQGSSKGCAVNKLNYPPYIPKILDDLMYSKTLCMDAKQTWGNHYDVHSLYGYSMVLATKKAMDRVFGENRSMMLTRSSFPGVGKYSGHWLGDNAATWNDMKWAIPGMLEFGLFGIPYIGADICGFFDDSPEELCRRWMQVGAFYPFSRNHNAEGYKPQDPASYGADSVLVASSKHYLTIRYTLLPYLYTMFYKAHTTGETVVRPVMHEFYSDSETWTVDRQFLWGKHLLITPVLDPGVDMVWGYVPDALWYDYENLMSLPHTGIHTHTHTHTHTHTHTHTHTHKCAHNFILHNSFILLDYIHWMDLFIYSYVCNFTFVSVYLTSRRNPMGLLIAPDDNGNADGELFWDDGDSRDTIENGNYIHYKFSLKQGVLTMQVTHAGYSDPNNLKFDNITILGIPVPPVSISVTHVGTTNSTTTLEPSNIHHDGDKKVLFLRDLRLTLGETYVLEWEVIRIDCHPEEHADQANCEARGCIWDVSKKWSYAHIHMYYGYTVTSVRERSSGMTLDITRNRKYRSSGRPQSRDIDTLRVEINYHTGEIQWCICIDSTYMLILYKVVIVNEPFGIQVIRKSTGTVIWDSSVPGFTFSDMFIQVSTKLPSQYVYGFGETEHLTYKHDLNYHTWGMFAKDQPPGYKMNCYGVHPFYMGLENTADAHGVLLLNSNAMGYASNKKFLLVLIGRPVLPAYWSLGFQLCRYGYANDKEIADLYKDMRAAAIPYDVQYADIDYMERQLDFVLDSEFKGLPALVDSMRKEGMRFIFILDPAISGNETQPYPAFARGKAADVFIKWPKHISDGIVWGKVWPDYPNVTVDENLDWDTQVQLYRSYTAFPDFFRPETAQWWHQEIKEFYEKTMKFDGLWIDMNEPASFVHGTVDGKCLGDPKLENPPYMPPLESKHLGLNHKTLCMNSEQILSDGTRVRHYDVHNLYGWSHTKPTYDAVLDVTGKRGIVVTRSTYPSSGKWAGHWLGDNNASWDQLYKSIIGMMEFSLFGIPYTGADICGFFNKPDYEMCLRWMQLGAFYPYSRNHNGKGNPRQDPVAWDKPFAEASRDVLNIRYTLLPYLYTLMYEAHTKGNTVIRPLLHEFVDDKSTWEIYKQFLWGPALLISPALDPGVTNVNGYLPNARWYDYHTVNVGVRGQMINMPTPLDHINLHIRGGYILPWQKPENTTYYSRKNPLGLIVPLSDSGTAEGSLFWDDGEGIGNQVTHNGLTAGDRLKLGVVKVWGAGSTKITKVTLTVAGVAHNLTPEHNVDSQVSAFVGCSFLLYTSKHCRFLYLNVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CX07</accession>
    <name>A0A3P9CX07_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SH3 and multiple ankyrin repeat domains 3a</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005026527"/>
    <dbReference type="Ensembl" id="ENSMZET00005027384.1">
        <property type="protein sequence ID" value="ENSMZEP00005026527.1"/>
        <property type="gene ID" value="ENSMZEG00005019780.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153561"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SAM_Shank1_2_3"/>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
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        <property type="entry name" value="SAM"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
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        <property type="entry name" value="SH3_domain"/>
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        <property type="entry name" value="SHANK"/>
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    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF4">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 3"/>
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        <property type="entry name" value="Ank_2"/>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="2" id="KW-0770">Synapse</keyword>
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        <location>
            <begin position="166"/>
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        </location>
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        </location>
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            <begin position="1602"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
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            <dbReference type="PROSITE" id="PS50002"/>
        </source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1665" mass="182383" checksum="DEEC1E214733AB35" modified="2025-10-08" version="2">MMPLNFSPVLKCLKFNVDAPIWLSKQRILCTLNQSLKDVLNYGLFQPAYNGRAGKFLDEERRLREYPFPSIAPVPYLETCLHSTYLDEKQLSKLHTKANLKKFMEYVQQRNIEKVSRFLEKGLDPNFHDPDTGECPLTLAAQLESCAELIKVLKSGGAHLDFRTKDGITALHKAVRSKNHTALITLLDLGASPDYKDSRGLTPLYHSSMVGGDPYCCELLLHDHAQVGCVDENGWQEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHVCALYNQESCARVLLFRGANKEIKNYNSQTAFQVAIIAGNFDLAEIVKVHKASDVVPFRETPSYTNRRRVMPGPLPSPRSLLRSASDNNLNGDHDHIHAQPTREARGRQGHSPVPSLRSLPAFGQQHSSLGEVSEVAPGSVQRDPSPPHHTPPALSGSRGPKRKLYSAVPGRTFIVVKPYTPQGEGEIQLNRGERVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQYDPRLETREDRTKRLFRHYTVGSYDNFTSYSDYIIEEKNAVLQKKENEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVSLIRQGGNRLLMKVVSVTRKPETEEVVRKKAPPPPKRAPSTTLTLRSKSMTAELEELASARRRRGERLDEMLASQESMLRSQPSEADYRAATVKQRPTSRRITPAEISSLFERQGMTLHGGLHPGIERGHIQLPKGMSRTKSFGKEDRLSALVGEHRFPRSSSMTDSLRDHSQPHPIPPPPQTAPPPPPYYLDTGPPPAFCPPPPPSRTQSQGHEPAGRSSFKPSSLDLPYEAAQRQATHIERQKKARSMIILQDSSHLPVEPTEIPRPSAATPPERIKRKGRVIDNPYANVGQFSIGLYTPTKPQRKKSPLVKQLQVEDAQEKASLALAAAHSRESSPSGRHPLTYGHTHTSRRRLEERRKSTVFLSVGTMEGASTTSSDSPSLTQSHSIDERMLTRELGQLPPPALALSPSPSGTTFIHPLTGKPLDPNSPLALALAARERALTSQSQSPTSSPEPRTKQEQLGQGVIFIDTQTKESPHGEGAATSPPFSPKSAKVARIEERKEEKRLEDKKSMLISIMDTSQQKTAGLIMVHATSNGQAVGVDSEQEQTPAPDSREPSKSPSPRAKSPSPSVAQPQTQLQAQSSASPVQEKGLAQGSSEEDVDPYTVTLPPAMLSSSDEETREELRKIGVVPPPDEFANGLLAQAQGAPVSPANAAAVSGKPSDPLEPPPVGESGSAADSGVEEADTRSSSERERDHHLETTSTVSTVSSMSTLSSESGEPADTHTTHTSYADGQTFVLDKPPVPPKPRLKSQIGGSKGPVTFRDPLLKQSSDSELLSQQQAAALAAAAPRYLFQRRSKLWGDPVEPRGPGVGLAKPSVMGELSSRLQQLNKDTRSLGEEPLGASLDPGRKSPVAGARLFSSLGELHTISQRSYGTTYTIRPGSRYPITRRTPSPGSPDRGDPLGRFSGYGLPTSPTTPPQTILKSSSLSLPQEPKEVRFVMRSSSARSRSRSPSPSPSHSPGLGSPLLALRPFHQKPLHLWNKYDVGDWLESINLGEHRAGFQEHEIEGSHLPALTKDDFAELGVTRVGHRMNIERALKQLLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CY42</accession>
    <name>A0A3P9CY42_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chondrolectin</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CY42"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026912"/>
    <dbReference type="Ensembl" id="ENSMZET00005027776.1">
        <property type="protein sequence ID" value="ENSMZEP00005026912.1"/>
        <property type="gene ID" value="ENSMZEG00005020080.1"/>
    </dbReference>
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        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000006">
        <property type="entry name" value="Layilin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051505">
        <property type="entry name" value="C-type_lectin_domain"/>
    </dbReference>
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        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789:SF1">
        <property type="entry name" value="CHONDROLECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14789">
        <property type="entry name" value="CHONDROLECTIN VARIANT CHODLFDELTAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C_TYPE_LECTIN_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018311757" evidence="7">
        <location>
            <begin position="31"/>
            <end position="264"/>
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    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="264" mass="29455" checksum="3DDF5152334EE7B9" modified="2019-02-13" version="1">EIKMTCSRIVIINRLMLGVVVAMGMVQVEAARVVSGQTVCVGGAERPCYKMAYFHDVSSRVAFSEARQACEMDRGALLSIESSTEQRDIEHLLQVRPTPADGDFWIGLTRVEGVDQTQSELSNALTSCPQLYQWTDGSVASFRNWYFDEPSCGGEACVVMYHQPTAPSGLGGAYLYQWNDDRCNMKHNFICKYNPGAISQSPWPELQVRRPATFDLIWAHDLMLRWSGVSAGMLLLYVVIPTIPLLLLILVASATCCFQMLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CY87</accession>
    <name>A0A3P9CY87_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CY87"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026781"/>
    <dbReference type="Ensembl" id="ENSMZET00005027639.1">
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        <property type="gene ID" value="ENSMZEG00005019971.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156149"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF4">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24056">
        <property type="entry name" value="zf-C2H2_ZFHX3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="397"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="579"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="752" mass="83332" checksum="0930104F3683D9E9" modified="2019-02-13" version="1">MLKGAGGTRLGGGEEGMFAPSLSPTGPLSQGVFQCLVCSCFSSDSLESVEQHLNAPRSLPQSEWCSLVAGGCHCRLCGYTTPLRANFSLHCQTDRHRTRYQLAAHLQEGGDRGQEGAALIAKGNPIQLRCNLCDYVTSSLEKLRGHSLSSHHEASVRVYRFLQQYDGEVDGGSWLFHCLLCNHSSSSKLQVLKHSQTPTHQQREGLLQLQPMGGEELAAIFTIRKSPDGVTEKNRVEEGEKKESVPSVKRPSSGCTEMENTILTKRPRTHQQNENHPRISLRDLCHLQIHTSLPSIFFSLPFPLFQTVQCPLCQVKLPYTQLRQHLTHVHSVAQDCVDKLISTVTAPKDVTALLTPPLEDNTTHPSNGRLAPQSPTQIPPSSPPTSPPGDPPPLSDRHGYRFRCSRCSLAFPTQEKLQLHWQYHAMRAATECPLCSRQCRSQEALQRHMQNTHSQLDSTQGQNTLWPPHTILSELGSSSLVKKSSNPTMDRYLDPSRPYKCTTCSESFTQKTILLVHYNSVSHLHRARRALQETGTSVAAPEAPRGPDPRPYRCRLCGVGYSQSSTLDIHLRSVLHQTRARAAQNPTSQTPASTVAVPQSVPTTATQAATTREETLKSLPFTKRPDGMSSSNSSLAGSGLVADAQPILSNPTESPQAKKRVSDLLASRNQLMLIQQQQIAQAQVQAQLQQHTALLQSQVMQSHRTPNRQECETLGQELGLPHRVVQVIVFKYLRLKKKKKRGKIFKMIFDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZC0</accession>
    <name>A0A3P9CZC0_9CICH</name>
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        <submittedName>
            <fullName evidence="2">HHLA1 neighbor of OC90</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_023009563.2">
        <property type="nucleotide sequence ID" value="XM_023153795.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZC0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027322"/>
    <dbReference type="Ensembl" id="ENSMZET00005028194.1">
        <property type="protein sequence ID" value="ENSMZEP00005027322.1"/>
        <property type="gene ID" value="ENSMZEG00005020383.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064699"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037643">
        <property type="entry name" value="HHLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15299">
        <property type="entry name" value="HERV-H LTR-ASSOCIATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15299:SF3">
        <property type="entry name" value="HERV-H LTR-ASSOCIATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="518" mass="56484" checksum="5CA8152D0CB85041" modified="2019-02-13" version="1">MAGSWRFTQHPRFSFIICVSAVLILLLVSQALICRQQEDRHRRDFADSTEIPAEHIDPAAIDLTPLVNTLINSSHSGSRQLFSLLSVTSYSSLALHKLTLLVYNISSVGSIESSVFRRRFCYCVTNETNDLTDFTAILLDVMGNSTSYLHELFKSSSILSVSQRNNSDCIYICVMAGREVPELWDVGSITPLFNQTIVEGPHTANISFRLPVEWHQLPTNLSHISPSGMSSMLTSRVHSTAHASPTAVDEAAASTAKVTTAQPLATAPQPTTVKPQSYTTAETPETIQQPMAPSMTTRAVTTQRGTTPTVASSQSGTIVEKTTLAPITTLKRQTTTTAAPTAAAPTTAAPRLPTTPGRASTFSPAVSLIRTPPSTSTAAPHTTSTVHSTRLPPVRASAGPTVPRRTTGPLVRGTTTPSKPTEKPGCPWRRPELSAESVPGAATTVGAHKLQPCVLELCKFFSQCLCRPFSHKTRMKRYCDDSHLWYEKHTSEVCRRVRRVSFSRNLKQRCLTKMCNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D031</accession>
    <name>A0A3P9D031_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D031"/>
    <dbReference type="Ensembl" id="ENSMZET00005028309.1">
        <property type="protein sequence ID" value="ENSMZEP00005027436.1"/>
        <property type="gene ID" value="ENSMZEG00005020455.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286939"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002281">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001290">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000759">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000540">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000161">
        <property type="entry name" value="Zinc finger protein 366"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000017">
        <property type="entry name" value="zinc finger protein 62 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000771">
        <property type="entry name" value="zinc finger protein 648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="662" mass="73542" checksum="645DE6EEEBBFBF9E" modified="2019-02-13" version="1">MWESRPKPQHIEDISKKQPTPASTDPVVVPLTTMKQPRRRQCIDSGNRSFTCDQCGKSFTRSSSLKVHQLIHTGVKAFSCDQCGKSFNRLGPLKTHQLIHTGIKAFSCDQCGKSFTLSSNLKRHQLIHTGVKAFRCDQCGKSFTLSSNLKVHQLIHAGVKAFSCDQCGKSFNRLDHLKAHQVIHTGAKAFSCDQCGKSFTQKSDLKTHQLIHSGVKEFSCNQCGKSFTQKRYLKRHEVTHAGVKSFVCSQCGKAFTQIGNLKRHEVTHAGVKSFVCGQCGKAFTQIGHLKRHQVIHAGVKSFVCGQCGKGFTQIGHIKTHQLIHAGVKAFSCDQCGKSFTQIGHLKSHQVIHSGVKAFVCGQCGKAFAHSYSLKVHLLTHSGVKPFSCDQCGKSFTLIGHLKTHQVIHSGVKPFVCGQCGKAFAHSYSLKVHEVIHPGAKHFSCDHCGKSFAFNCDQCGKSFNQKRDLKQHELIHSGVKAFVCDQCGKSFTFIGHLKRHQLIHSGVKSFICNQCGKSFTQSCNLKRHQLIHTGVKPFNCQLKAHKRVHTGEKPYKCTYCDKSFSHSNSRILHERTHTEGNYSCDQCDKSFKNLSSYSRHKRSHAVNKQFQCDQCAKTFTSLSALCKHQHDHPGEHPGGKHLNLVREQHHAGQTSSTEGCAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1I1</accession>
    <name>A0A3P9D1I1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1I1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027961"/>
    <dbReference type="Ensembl" id="ENSMZET00005028852.1">
        <property type="protein sequence ID" value="ENSMZEP00005027961.1"/>
        <property type="gene ID" value="ENSMZEG00005020858.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177781"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="409" mass="45579" checksum="478A199C0573FC2A" modified="2019-02-13" version="1">EGEECAQEEVKQALEPVSHKALVAEQRKQVATPLERCHSKLLLHISIFHCFIFALPLMLFPLSFLLLPLLFSKVQARIAFSSYLQRVQQRLLAESRDNTISAWPDNGNDQMELVICFLRKAASNLQQNIKVVLPSRQLPLQDRRRILSHQLGEFIHCYNKETEHMVKKQEISKEERCVNPKVFQEYISAASENDLEEVLTFYTQKNKSATVFLGTKATDGQPSFCLLPEDIRAEVRMVKTQPEVQSSQHRSSFPVTLDCVHNHVQHCSPASLPLHCPPPPPPPQPPSYAQSLAKSHLCHSESISDPPAYTSAHVVTQPPRVLWTAAPTGSNAATTGPSTQVLRRIQSFTSSMAGSAAASSVPSATHIYSQKLSRPTSAGQGNLSCTACWCFKSNSQRCSHLFLFVFLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3R8</accession>
    <name>A0A3P9D3R8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RFX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Regulatory factor X 6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3R8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029280"/>
    <dbReference type="Ensembl" id="ENSMZET00005030200.1">
        <property type="protein sequence ID" value="ENSMZEP00005029280.1"/>
        <property type="gene ID" value="ENSMZEG00005021835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244879"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031018">
        <property type="term" value="P:endocrine pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000211">
        <property type="entry name" value="Regulatory factor X, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF28">
        <property type="entry name" value="DNA-BINDING PROTEIN RFX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="10">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="832" mass="91736" checksum="C02A09901CC724FD" modified="2019-02-13" version="1">LYVFTSEESNETPSSEEDQDLVDLNSDLSIKQSIPSSRKTISQIIKDKKKQTQLTLQWLEENYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGSKLKNEGGFTRKYSLSSKTGTLLPDFPSAQHLLLQGNISREKVDTLIMMYKTHCQCILDNAINVNFEEIQNFLLHFWQGMPDHLLPLLENPVIVDIFCVCDSILYKVLTDVLIPATMQEMPESLLADIRNFAKHWEHWLASSLENLPECLAAKKLPIARRFVSSLKRQTSFLHLAQIARPALFDQAVVTSMVLDIDNVDLSSISSQPLLSVTANGDQDPDIYSEYDSITVFQELKELLRKNATVESFIEWLDSVVEHKVIKPGKQSGRSVKKRAQDFLLRWSFFGARVMHTLTLNNASSFGSFHLIRMLLDEYILLALETQFNNDKEQDLQNLLDKYMKNADASKAAFMASPSSCFLANRSKATAATDQPVKNESLGEHAYMSLSTNQQSLEGKTVIYQGTETSGFTVSGPQMDFSQVSGPLMTPPISPAGLVHRGSVINQGPMAGRPLIPCSSYTETLYHCLPQTTSGYFPPASSQASSLACHLSRTNCSLAPYASAVRPSSAYTSGSDPAHSEQGLDPQVAAQILDSAEGFGFVETGLNLPGGGCQAQTYSVTGPSYYGNSSYLESQRMTSLVDQHVSVISSVSSLRPFPSTYSEVHDPLNILDEPGRKPAGAFYSEAENGADHSLSSSGSAPCMFGLPSQFTSQESLLSQQRVTASSEVQDLVSSLPPINTVFMGTGGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3T5</accession>
    <name>A0A3P9D3T5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cysteinyl leukotriene receptor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3T5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028751"/>
    <dbReference type="Ensembl" id="ENSMZET00005029659.1">
        <property type="protein sequence ID" value="ENSMZEP00005028751.1"/>
        <property type="gene ID" value="ENSMZEG00005021445.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286937"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231:SF52">
        <property type="entry name" value="CYSTEINYL LEUKOTRIENE RECEPTOR 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231">
        <property type="entry name" value="PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="342" mass="38878" checksum="B29741372F91726F" modified="2019-02-13" version="1">MSMTVATNNNTAKSHLACFHEDDAFKYSAYRYTYLLVFPVAFICNIGALAVFFRQSSRRRSASCVIMMNLAISDGSFSLTLPLRLAYYFNEGKWFFPDWMCRLCVFGFYVNLYTSILFLTLLSVLRWLAVAQPLRHRSLATPARTLWICLGVWVFVGGSSVPFLSNGVVHRNNATRCFEPETPRSWSIILVLNYVAVTFGFLIPFLTIIICYSKIIRQLTADSSPSGTNLASKNRTRNRRRSVHLVSMVTVTFLLCFLPYHLVRSLHLHAVCNRWNCNILLALQRGVVVTLCLAASNSMVNPLLYYYSTRTFRENMREAHSSLLSSRGGSIKASSMKRRNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6G4</accession>
    <name>A0A3P9D6G4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cellular repressor of E1A-stimulated genes 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
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                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
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                <person name="Lee A.P."/>
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                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Amemiya C."/>
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                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
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                <person name="Kocher T.D."/>
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                <person name="Venkatesh B."/>
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        <source>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D799</accession>
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                <person name="Harris R.M."/>
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                <person name="Jaffe D.B."/>
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                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D799"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030438"/>
    <dbReference type="Ensembl" id="ENSMZET00005031397.1">
        <property type="protein sequence ID" value="ENSMZEP00005030438.1"/>
        <property type="gene ID" value="ENSMZEG00005022680.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158146"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10493">
        <property type="entry name" value="MH1_SMAD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10499">
        <property type="entry name" value="MH2_SMAD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000004">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000003">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF28">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="9">
        <location>
            <begin position="136"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="10">
        <location>
            <begin position="322"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="488" mass="54429" checksum="2BDDB5F0B484CFD9" modified="2019-02-13" version="1">MFRTKRSGLVRRLWRSRLIPDKEGEDGIGKSGEGCRDDLFSYNPEKIPKTEFRPMTPSGSLVLDIGGVCPVESSDLRVTSDQDGGAACAQEQGSPRSLQDSECRTVTCCLFKDQDHSELRGAETAQGTRGPGSCHFGLRNLGPGESDSPEAQEAMPRTVLEQELKSATYALLKRLKEKALDTLLEAVESRGGMPSDCVMVSRTELRFGGHVASPQLLVCKLYRWSDLQHSAQLKPLYECRSFGAPDSPTVCCNPYHYSRLCGPESPPPPYSRLSPNEEHKPLDLSDSTLSYTETEAASSPNITPGEFSDASMSPDAPKQSHWCNVAYWEHRTRVGRLYTVYEHSVSIFYDLPQGTGFCLGQLNLEHRSSTVQRTRGKIGYGILLSKEPDGVWAYNRSEHPIFVNSPTLDVPNSRTLVVRKVMPGYSIKVFDYERSFLLRHTTEADLLDGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7C4</accession>
    <name>A0A3P9D7C4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanylate cyclase soluble subunit alpha-1</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Soluble guanylate cyclase large subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004549542.1">
        <property type="nucleotide sequence ID" value="XM_004549485.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7C4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030254"/>
    <dbReference type="Ensembl" id="ENSMZET00005031204.1">
        <property type="protein sequence ID" value="ENSMZEP00005030254.1"/>
        <property type="gene ID" value="ENSMZEG00005022547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483862"/>
    <dbReference type="KEGG" id="mze:101483862"/>
    <dbReference type="CTD" id="2982"/>
    <dbReference type="GeneTree" id="ENSGT00940000158285"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090594">
        <property type="term" value="P:inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000002">
        <property type="entry name" value="guanylate cyclase soluble subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000007">
        <property type="entry name" value="Guanylate cyclase soluble subunit alpha-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF4">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="13">
        <location>
            <begin position="490"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="678" mass="75184" checksum="DE257A2A044ACDBE" modified="2019-02-13" version="1">MFCAKLKELKISGECPFSASAKNNELGDFEERSTETADLLPVSKDVHGKTGEGVPRKKTSRAKVNLHTLGDSIRKLACPEFQRLHTALQRMMTLSDHSRDSESLAISCSHHQSCSSEPEHLLEMMNIHSVKTGIPIEALKIALGEEIFNMCYEEDSHILTVVGGALHDFLNSFNVLLKQSSMLPNPDRRDCVNEPSVLCLDKDPGLLTVYFFNPCTTTELFFPGVIKAAARLLYNTTVDVVMDLQHGRDTILQSSPQPSLLYTVVVKDTKNLSPSPLRATSAGTLPTSLFSTIFPFHLILDQDLVLVQVGHGLRKRLIRKDGLRRFSTFQDHFSIVSPQIKCTFQGILTMLNAQFIIRIKHGVATTDNTGKHMDLKGQMIYVSESNAILFLGSPCVDKLEELTGRGLYLSDIPIHNALRDVVLVGEQAKAQDGLKKRLGKAKAALEHAHQALEEEKKKTVDLLFSIFPGTVAQQLWQGETVQAKKFDHVTMLFSDIVGFTAVCSICTPMQVITMLNELYTRFDHQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNGVMTPTGEPIQMRIGLHTGSVLAGVVGVKMPRYCLFGNNVTLANKFESCSQPRKINISPTTHRLLKGRPEFVFVPRSRQELPANFPDDIPGVCYFLEASVKTSKLNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCN9</accession>
    <name>A0A3P9DCN9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipid phosphatase related 5b</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCN9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031917"/>
    <dbReference type="Ensembl" id="ENSMZET00005032951.1">
        <property type="protein sequence ID" value="ENSMZEP00005031917.1"/>
        <property type="gene ID" value="ENSMZEG00005023811.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158610"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03384">
        <property type="entry name" value="PAP2_wunen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF17">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE-RELATED PROTEIN TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="134"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="407" mass="45061" checksum="68FB01EE85C66868" modified="2019-02-13" version="1">SNDLDWIFLFNWTNVVTDADSIMLYFQVVILAATVMLVYYCEFTDTFSPAEQGFICRDPTLTKPDPGPEQNSRMPPIILYSVVSGLPVVLISGVEVVIFLFYYNSNNFYEQEKVVVVGDCCYVNPMVRRTVRFLGVFVFGLFTTDIFVSTGQMVTGSLAPYFLSVCQPNYTALGCQDTAFFVSQSDGCTGDPDDIIRARKTFPCKEAALSVYLAVYLAVMGRLAGPFVSLSLVSLALLTGINRVAEYRNHWSDVIAGQGIGAGVAVFLVTEKPTPPFPQPSPPAFPVEHQGVPRPAERYNLASVSLTCPWAPSRWNMPGTPHLGIPGGILVRCPIHLNWLLSMWRSSSSTLSPSRMAELPTLSLRDRASHPSEEAHFCRLYPRSRSFSHYPQLVTIGEGRDVDRPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DD74</accession>
    <name>A0A3P9DD74_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periphilin-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004546143.1">
        <property type="nucleotide sequence ID" value="XM_004546086.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DD74"/>
    <dbReference type="Ensembl" id="ENSMZET00005033505.1">
        <property type="protein sequence ID" value="ENSMZEP00005032458.1"/>
        <property type="gene ID" value="ENSMZEG00005024176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473893"/>
    <dbReference type="KEGG" id="mze:101473893"/>
    <dbReference type="GeneTree" id="ENSGT00390000016228"/>
    <dbReference type="OrthoDB" id="8933311at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097355">
        <property type="term" value="P:protein localization to heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22896">
        <property type="entry name" value="periphilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057603">
        <property type="entry name" value="Periphilin-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028851">
        <property type="entry name" value="Pphln1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836">
        <property type="entry name" value="PERIPHILIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836:SF4">
        <property type="entry name" value="PERIPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25234">
        <property type="entry name" value="Periphilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Periphilin-1 C-terminal" evidence="2">
        <location>
            <begin position="192"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="276" mass="32640" checksum="5CD39E25F54D0993" modified="2019-02-13" version="1">MDQARPQTTQESKGSVSQRYKEHSDDSTDKRATDNTVSPAKDEKRAIRRVRSPSRPRAWLSTSYKPKFAGRFHKPRFTRDDHAFHKAGFGTQRHHHTSHWAYVHRRDHFHSKLHHIPLKERVRLKEQEKEKYKRRESTEGSSSPKQENTTRPFTSRSSSSRDKDMQFTSNRNQSRERDHKGTKSKERSGERELPSTVSQTAARDRAIQQKRKEIDEVYYQECEMFGFVVKMLIKKDPSLERPIQSSLQQNLRDIGKRCVEAMEKFIEDYDSRELSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDL5</accession>
    <name>A0A3P9DDL5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DDL5"/>
    <dbReference type="Ensembl" id="ENSMZET00005033295.1">
        <property type="protein sequence ID" value="ENSMZEP00005032252.1"/>
        <property type="gene ID" value="ENSMZEG00005024027.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278876"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="29"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="187" mass="21279" checksum="0B148BF86BF2969B" modified="2019-02-13" version="1">IPANNNTLFFLVSFLILTLSLCSVLFPLPDPEIVTVLSGQNVILPCQALRDKGSLRAVAWTKPDLQNKNVYLYRDGRFDPADQNPSFKNRVDLQDRQMKDGDVSLILKDVMINDAGKYECSVIQKKDLSPSTTTITLDLRVINSKVVLLDWPLVCIFLLCFLLLLLFCSYRKFKENSQCSNQPHFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEM4</accession>
    <name>A0A3P9DEM4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Atypical chemokine receptor 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555418.1">
        <property type="nucleotide sequence ID" value="XM_004555361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DEM4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032819"/>
    <dbReference type="Ensembl" id="ENSMZET00005033878.1">
        <property type="protein sequence ID" value="ENSMZEP00005032819.1"/>
        <property type="gene ID" value="ENSMZEG00005024442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486333"/>
    <dbReference type="KEGG" id="mze:101486333"/>
    <dbReference type="GeneTree" id="ENSGT01030000234667"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000035">
        <property type="entry name" value="C-C chemokine receptor type 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005383">
        <property type="entry name" value="ACKR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000355">
        <property type="entry name" value="Chemokine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF910">
        <property type="entry name" value="ATYPICAL CHEMOKINE RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00657">
        <property type="entry name" value="CCCHEMOKINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01558">
        <property type="entry name" value="CHEMOKINER11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="53"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="368" mass="41538" checksum="2459E421ECCADD32" modified="2019-02-13" version="1">MEFSEEDYDYENTTYNFTYDDYPAVCEKGDIRSFAALFLPIMYTVCLVVGLAGNVLVVAVYAYHKRLKTMTDAFLTHLAVADLLLLLTLPFWAADAARGWELGEVVCKIVSACYTVNFTCCMLLLACISLDRYLSLVRAQDRDQRRWLQRAFTRKCCWKVCLAVWVTAFLLGLPDLILSEVRQASDRNICLTIYPSSMARGGKAVLEVVEVLLGFLLPLLVMVTCYWRVGCALRGLPDESRGKKWKALRVLLIVVGVFVMTQLPYNVVKVYRAMDTVYSLVTHCGASKVLDQAAQVTESLAHTHCCLNPILYAFVGSSFKMHMMRVAKKFEAKRRKRGSKTTETNVEEGMEMSFNSHTASQETNSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DES0</accession>
    <name>A0A3P9DES0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DES0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032662"/>
    <dbReference type="Ensembl" id="ENSMZET00005033720.1">
        <property type="protein sequence ID" value="ENSMZEP00005032662.1"/>
        <property type="gene ID" value="ENSMZEG00005024306.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164025"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="143" mass="15438" checksum="B5DBC63F6213CCD3" modified="2019-02-13" version="1">MVSQGIQITGITMAIVGWLLEITACGLPMWKVSAFIGANIVTAQTFWKGLWMDCVVQSTGQMQCKVYDSMLALESDLQAARAMIIIAILVGVFGLILSVAGGKCTNCIKEERSKAKVCICSGVLFIISGFLCLIPVCCCWTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGJ5</accession>
    <name>A0A3P9DGJ5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Odorant receptor, family 6, subfamily AT, member 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGJ5"/>
    <dbReference type="Ensembl" id="ENSMZET00005034375.1">
        <property type="protein sequence ID" value="ENSMZEP00005033251.1"/>
        <property type="gene ID" value="ENSMZEG00005024813.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162014"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000013">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="48"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="302" mass="33877" checksum="FEA6EB62EF531148" modified="2019-02-13" version="1">EVCRSSCIFEGIISSFCLYFVFNLAYPKHLKNTLIFLQKYIVKIDEGEDRPLPITALTDPKLNSPLYFFLCNLSFVDMVYTTTTIPNMLSGLLTDILTISVLGCFLQMYFFIQLTVTGRAILTVMAYDRYVAICNPLQYNSIMTRPVRLLLVAGAWGFGAICTLPVTVIAFERPYCGPNVVKHAWCDPSSVRRLVCSDTSLDNIVSLLFAMVSLVTTSVFILSSYILIGFSISRMVVAQRLKALRTCSAHLTVVSISYVRIIVSVLYSALTPFLNPMIYSLRNKELRESIRRTLNKTAGGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHA2</accession>
    <name>A0A3P9DHA2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dual-specificity kinase</fullName>
            <ecNumber evidence="3">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHA2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033759"/>
    <dbReference type="Ensembl" id="ENSMZET00005034945.1">
        <property type="protein sequence ID" value="ENSMZEP00005033759.1"/>
        <property type="gene ID" value="ENSMZEG00005025241.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160345"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001706">
        <property type="term" value="P:endoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14226">
        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000264">
        <property type="entry name" value="dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF12">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="86"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="363"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="437"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="507"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="550" mass="61772" checksum="50F3B77D2B394F91" modified="2019-02-13" version="1">MTILQRRIPPSFRDPASAPLRKLSVDLIKTYKHINEVYYTKKKRRAQQVPPEDSSTKKERKIYNDGYDDDNYDYIVKNGEKWLDRYEIDSLIGKGSFGQVVKAYDHHEQEWVAIKIIKNKKAFLNQAQIELRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGVPPSHMLDAAPKARKYFDKLSDGLVCPLPDLILRMLDYDPKSRITPFYALQHNFFKKTTDEGTNTSSSTSTSPAMDHSHSASTTSSVSSSGGSSGSSNDNRNYRYSNRYYNSAVTHSDYEMTSPQVPLSLFRHFLDPPHHPHPTYSHHGNGGRGLRQGGQTGIGGGGGPQGSSPQMSDSMDVSFGSASLPLALPIGLSAFRTRTAPTAPGPQAQPPEDYYPASNNNNPTGGGRGRPDSDEGPANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJ28</accession>
    <name>A0A3P9DJ28_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJ28"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034765"/>
    <dbReference type="Ensembl" id="ENSMZET00005036003.1">
        <property type="protein sequence ID" value="ENSMZEP00005034765.1"/>
        <property type="gene ID" value="ENSMZEG00005025989.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157037"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15057">
        <property type="entry name" value="7tmA_D1-like_dopamine_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000929">
        <property type="entry name" value="Dopamine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF123">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00242">
        <property type="entry name" value="DOPAMINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="54"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="366" mass="41134" checksum="5FF50F9D3D77876E" modified="2019-02-13" version="1">METFYNHTRNQRQDQSQHPVVTAAADSPAHGSHLSLRALTGCVLCVLIVSTLLGNALVCAAVIKFRHLRSKVTNAFVISLAVSDLFVAVLVMPWRAVSEVAGVWLFGRFCDTWVAFDIMCSTASILHLCIISMDRYWAISSPFRYERRMTRRFACVMIGVAWTLSVLISFIPVQLNWHRAGAQNATDPGDCNASLNRTYAISSSLISFYIPVLIMVGTYTRIFRIARTQIRRISSLERGCRAVHRRPRASAHEESSLKTSFRRETKVLKTLSRLGAPPCVSDTTFSVFVWFGWANSSLNPVIYAFNADFRKAFSTILGCSRYCATSAVEAVDFSNELVSHHDTTLQKEFVRVTGTPYHFLLMLFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJS1</accession>
    <name>A0A3P9DJS1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized LOC101463896</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004546205.1">
        <property type="nucleotide sequence ID" value="XM_004546148.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJS1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034619"/>
    <dbReference type="Ensembl" id="ENSMZET00005035843.1">
        <property type="protein sequence ID" value="ENSMZEP00005034619.1"/>
        <property type="gene ID" value="ENSMZEG00005025872.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463896"/>
    <dbReference type="KEGG" id="mze:101463896"/>
    <dbReference type="CTD" id="203328"/>
    <dbReference type="GeneTree" id="ENSGT00940000168452"/>
    <dbReference type="OrthoDB" id="9939976at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053067">
        <property type="entry name" value="SUSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46879">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46879:SF1">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="309" mass="33573" checksum="F2C2CCBC7C7066B1" modified="2019-02-13" version="1">MSAATASISDVSRTDTANKNDRNKSGNSKAQCTPMPQPTLGNHQIIQGNGTNVGTVISLQCPGKHKLVGSDMMCVMGPNSTYWTGDSYCQALSPNDFGYRVAVVASFVSSGIILFMSVAFITCCLLDCIKEEERKKEENDSDPWQWEEPTPNQENNMSRYSHKGRNNNNNNTQENPLSPWDTAGPTLCDSIRSCRCHQHYAYCPACTNYGPTPPPAALPGHDYNQPLLLQMPEPDPPQYPGPPLSSCQSTSPGLVQISAGGSGLVWQYEGQQSSLSGANLLTADEAPGRNINSNRNIYPKELSIRIISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMY1</accession>
    <name>A0A3P9DMY1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Plexin-A2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560456.1">
        <property type="nucleotide sequence ID" value="XM_004560399.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004560457.1">
        <property type="nucleotide sequence ID" value="XM_004560400.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004560458.1">
        <property type="nucleotide sequence ID" value="XM_004560401.2"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005035491"/>
    <dbReference type="Ensembl" id="ENSMZET00005036743.1">
        <property type="protein sequence ID" value="ENSMZEP00005035490.1"/>
        <property type="gene ID" value="ENSMZEG00005026519.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005036744.1">
        <property type="protein sequence ID" value="ENSMZEP00005035491.1"/>
        <property type="gene ID" value="ENSMZEG00005026519.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478991"/>
    <dbReference type="KEGG" id="mze:101478991"/>
    <dbReference type="CTD" id="5362"/>
    <dbReference type="GeneTree" id="ENSGT01050000244850"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001763">
        <property type="term" value="P:morphogenesis of a branching structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003403">
        <property type="term" value="P:optic vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035295">
        <property type="term" value="P:tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IPT_plexin_repeat1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IPT_plexin_repeat2"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd01181">
        <property type="entry name" value="IPT_plexin_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12790">
        <property type="entry name" value="RasGAP_plexin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000123">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000006">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000071">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000131">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000339">
        <property type="entry name" value="Plexin A2"/>
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        <property type="entry name" value="Plexin A2"/>
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        <property type="entry name" value="Plexin A2"/>
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    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
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        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
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        <property type="entry name" value="Semap_dom"/>
    </dbReference>
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        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
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        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLEXIN-A2"/>
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        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sema"/>
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        <property type="entry name" value="TIG"/>
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        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
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    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1245"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="19">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1271"/>
            <end position="1298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1901" mass="212107" checksum="1F6F33B9F61EF42C" modified="2019-02-13" version="1">MEGQQAFRRTLSLNPKVGPMAALLGFWLIVIPALSNGQTFTSFHPERRDWVFNHLTVHQTTGALYIGAVNRVYKLSGNLTLLVSHDTGPEDDNKACYPPLIVQPCSEPLVSTNNVNKLLLIDYSQNRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNQTGTMYGVIVPSQGQDGTLFIGTAVDGKQDYFPTISSRKLPRDPESSAMLDYELHTDFVSSLIKIPSDTLALVSHFDIYYVYGFASGSFVYFLTVQPETPENSMSSSGSGSDLFYTSRIVRLCKDDPKFHSYVSLPIGCVKSGVEYRLLQAAYLGKPGRVLAASLNISAHDDVLFTIFSKGQKQFHRPPDDSALCVFTIRDINARIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDSFCGLDINQPLGGSQLVTGHTLYTETRDRMTSVTSYVYNGYCVAFVGTKSGRLKKIRVDGPPHGGVQYETISVIKDGSPVLRDMAFSLDRNYLYVMSERQVTQVPIESCEQYGTCGECLSSGDPHCGWCVLHNICSQRNRCERADEPYRFAASLNQCVKATVYPDSIAVSEPSVHLLVKVSDVPDLSAGITCSFGNLTEVEGQVNGNQILCKSPAAKDVPLIPTDQDWSGVELRLNSKETGQMLISTEVKFYNCSVHQLCLSCVNSAFRCHWCKYRNLCTHDPSSCSFQEGRVNASEDCPQLVRSEEILIPAGEVKPITLKAKNLPQPQSGQRGYECVLHIQGVSHRVTALRFNSSSVQCQNSSYLYEGMKISELPVDFSVVWNGNFIIDNPENIKVHLYKCAAQRDSCGMCLKAERKFQCGWCSGEGRCTLRHHCPPINPYTTRWLNLSSKNVKCTNPRITEVTPVAGPPEGGTRVTIHGTNLGLAFSDMVGNVEVAGVRCTPVEDGYIIAEQIVCEMDMAHADSMPGPVQLCVGECKPELRARSSQLYSFVTPTVTGLSPRRGPESGGTKVTIMGENLGAGSSVNVKFGNQTCEFFGRTKTEIVCYSAPSLSGVGPVQISVSVDRAQIRESLTFEYTEDPTVQRIEPDWSIASGHTPLMVTGTNLDVVQEPRIRVKYAGRESVNVCKVLNTTSMSCFAPSLMAEYHPGLDTVKHADEFGFIFNNVQALLVYNNTNLLYYPNPYFEPLSTTGILEQKPGSPIILKGRNLVPPASGGVKLNYTVLIGETPCSVTVSESQLLCEPPNLTGQYKVMVQVGGLHVSPGAVHIMSDSLLTLPAIVSIAAGGGLLLIIVILVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRAGIPYLDYRTYAMRVLFPGIEDHPVLRELEVSGNGQQNVEKALKLFGQLINNKVFLLTFIRTLEMQRSFSMRDRGNVASLIMTALQGRLEYATDVLKHLLSDLIDRNLESKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNMPYSQRPRAVDMDLEWRQGRMARVVLQDEDITTKIENDWKRLNTLMHYQVSDRCVVALVPKQTSSYNIPSSASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSTLPLAIKYMFDFLDEQADKHGIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYADINRLPAISDQDMNAYLAEQARLHSTEFNMLSALNEIYYYVSKYSEEITAALDQDEQARKQRLAYKVEQLISAMSFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNR4</accession>
    <name>A0A3P9DNR4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox protein Hox-C6a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNR4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036415"/>
    <dbReference type="Ensembl" id="ENSMZET00005037695.1">
        <property type="protein sequence ID" value="ENSMZEP00005036415.1"/>
        <property type="gene ID" value="ENSMZEG00005027180.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159254"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000879">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="140"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="234" mass="27003" checksum="391E1A21038B1FAB" modified="2019-02-13" version="1">MNSYFANPSLSCHLSGGQDVLPNVPLNSTTYDTVRHFSSYGAAVTQNRIYAPFYSPQDNVVFGSGRAQYEYGSNVFLQDKDVLPSCRQTNMGLNTQSHIAQEYSLDQGRAAAQEQKSNIPIYPWMQRMNSHAGVGYGTDRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTVTGTEQTGASQEQERNGAMEEGKDEDKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNY8</accession>
    <name>A0A3P9DNY8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
            <ecNumber evidence="3">3.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nucleoside diphosphate-linked moiety X motif 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP. Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57553"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67592"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="Rhea" id="RHEA-COMP:17276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
            <dbReference type="ChEBI" id="CHEBI:172371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67593"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + FMN + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67588"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="Rhea" id="RHEA-COMP:17275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
            <dbReference type="ChEBI" id="CHEBI:172372"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67589"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNY8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035998"/>
    <dbReference type="Ensembl" id="ENSMZET00005037265.1">
        <property type="protein sequence ID" value="ENSMZEP00005035998.1"/>
        <property type="gene ID" value="ENSMZEG00005026858.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002416"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01405">
        <property type="entry name" value="TETRPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="50"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="198" mass="22825" checksum="CF3BD976B40F618A" modified="2019-02-13" version="1">MSLWFDTLNLFYICGYKMLSSSNKVLSFLESKHTITEELCLCISCFNRKMVLRACGFIIFRRLVGRIPPPGNIEYLLLQTSYGEHHWTPPKGHVDPGEDDLTTALRETKEEAGLGAEHLKVIKGFVQELHYEVRGKPKEVLYWLAELKDPGTAVTLSDEHQDYRWAQLEEACTLARYKDLQDTLRAAHRHLEACQDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPS6</accession>
    <name>A0A3P9DPS6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Splicing factor 3b, subunit 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DPS6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036765"/>
    <dbReference type="Ensembl" id="ENSMZET00005038052.1">
        <property type="protein sequence ID" value="ENSMZEP00005036765.1"/>
        <property type="gene ID" value="ENSMZEG00005027407.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013215"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="75" mass="8811" checksum="EA7B71DEF106B4E2" modified="2019-02-13" version="1">MTDRYNIHSQLEHLQSKYIGTGHADTSKWEWLVNQHRDSYCSYMGHFDLKARVRFNLMEKMLQPCGPPADKPDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQQ8</accession>
    <name>A0A3P9DQQ8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cell division cycle 5-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024660400.1">
        <property type="nucleotide sequence ID" value="XM_024804632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQQ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036608"/>
    <dbReference type="Ensembl" id="ENSMZET00005037892.1">
        <property type="protein sequence ID" value="ENSMZEP00005036608.1"/>
        <property type="gene ID" value="ENSMZEG00005027301.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487762"/>
    <dbReference type="GeneTree" id="ENSGT00550000074922"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000091">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="17">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="16">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="16">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="17">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="202"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="812" mass="92225" checksum="9C2ECE35A7972343" modified="2019-02-13" version="1">MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEYLLDKAAQRDNEEEVGDDPRKLKPGEIDPNPETKPARPDPVDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIDVQKKRKKKRGVDYNAEIPFEKKPAPGFYDTSMEQYDAQEPNFKRLRQQHLDGELRNETEERERKKDKQKIKKKKESDLPSAILQTSGVAEFTKKRSKLVLPAPQISDAELEEVVKLGVASEVARQAAEESESANSASSTLLSEYSVTNTMATGLRTPRTPAAQDRIMQEAQNLMALTNIDTPLKGGLNTPLHESDFSGVTPQRQQIQTPNTVLSTPFRTPGPGQGSDGMTPQVGGAMTPRVGGTPGLTPGRTPLRDKLNINTEEQLADPAYAKHTQRESLQHLRQGLMSLPVPKNDFEIVLPENAEKELEETEAETGFIEDSADVEARKQAQRDAEREKELKLRHTPVQRSLPRPTEVNESVLRPASMEPLSDLQQAEELIKQEMITMLHFDCLHHPSANAANQLQRGKIRGPTSTSNNASHIAYLEKTSYKPISTEEMEQAKLVLAAEMEVVKGGMGHGDLSMEAYSQVWEECYGQVLYLPTQNRYTRANLASKKDRIESLEKKLDVNRGHMTAEARRAAKLEKKLKILLGGFQSRALGLLKQHSELWEQVEQAATELQTFTQLKKQEDTAIPRRQEALREDVERQMEREKELQQRYGELLMERESLLNSAQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRE1</accession>
    <name>A0A3P9DRE1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitotic spindle organizing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRE1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036812"/>
    <dbReference type="Ensembl" id="ENSMZET00005038101.1">
        <property type="protein sequence ID" value="ENSMZEP00005036812.1"/>
        <property type="gene ID" value="ENSMZEG00005027439.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005954"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="83" mass="9086" checksum="A3356E8E57807D21" modified="2019-02-13" version="1">MASAANANLNAVRETMDVLLEISRLLNTGLDMESLSICVRLCEQGINPEALSAVIKELRKASESLKVQTQPPLKLISSHCIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRH2</accession>
    <name>A0A3P9DRH2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inhibitory synaptic factor 2A</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Haplochromini</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3P9DRK2_9CICH</name>
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        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
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        <name type="common">zebra mbuna</name>
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            <taxon>Vertebrata</taxon>
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            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Lara M."/>
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                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
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                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <topology evidence="1 6">Multi-pass membrane protein</topology>
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        <text evidence="2 6">Belongs to the pecanex family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Pecanex_C"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        </source>
    </evidence>
    <sequence length="1622" mass="182504" checksum="3B3137A27FC37554" modified="2019-02-13" version="1">MGSQVVQTLRQGVWASLTGGWYHDPDQNKFNNSCHLYLWIFLLMLPLSLHLALPPTTMALSIYCSSITVFFVLIKLANYRLHLMFDEGEAVVRSSLSDLSKAQEKKSNASDSCLKSSTVPDSVAMTTLARKRPSSVIQVTVKQTETDPGLIGKIPVITFDSPEEEKQDSEEGEEVICSEDDPTPKQHMTTSQSEEFHLCRETTSSESTMLECADPEQKRLSLQITADSTPSPQLTNDNSSSGIDVHSHPDDTDSLEANVDSQGFLRLPQTLGRYGPGGRTHIRGLSMDSGKDAVPERPKPPTSLPTNTLQAIPPTQIPIVSPDPQTDREKDPDYDSLPSQTSQSESSMLQVICRPEATNKEEAYTFHTVHGDRPRKLYAERALNLPLGAELITGNMDLLSTSSNSECQDGLAGGHSDCPFQRRIIPAHRLRPRRTHPEIFQQEEDSLDDSSETSTQEKPARKIYYKLKLFPGKWINILYDRLTLLALLDNQDVLENLVAVFMAFLVSFLGFVLLNHGCFKDFWIFQFCLVIASCHYSLLKSVQPDAASPTHGHNQLVAYSRAAYFCIFCALIWVLEQLLRRKDLPVSSLYGVTIVCYDVLRFLRDLLVFTYCFPITFLVGLFPQINTFTIYLLEQIDMHFFGGTATSLISAVYSILRSLVALSLLYGFCFGALKEPWDEQHTPALFSGFCGLLVVLSYHLSRQSSDPSVLSLIKSKIMPALVESDEEEEDDTNIKDPLPEKLQNSMKEILLSDIIVCSVAYILTFAITASTVFLSLKPFVTIVLYALAGTVGFVTHYLIPQLRKHHPWLWISHPVLKTKEYYQFEPRDAVLMWFERLYVGLLCFEKYVVYPAIVLSALTNDGFALSHRKKLGICDVLLTTVAGLKLLRSSFCNPSFQFLTLLFTLIFFHFDCPRASESFLLDFFIMSIVFHKMRELLLKLHFILVYIAPWQIAWGSAFHAFAQPFAVPSAMLLLQTLLTTVFYTPLAPFLGSAIFISSYPRPIKFWERNYTKRIDNSNSRLVSQVDKETCDDNNLNSIFYEYLTRSLQHSLCGDLMLGRWGNYSAGDCFILASDYLNALVHLIEIGNGLVTFQLRGLEFRTYCQQREVEAITEGVEEDDACCCCEPGHLPHMLSCNAAFNLRWLAWEVMATKYLLEGYSISENNAATMLQVYDLRKLLITYYLKSIIYYLVHSPKLSTWLKDATIQEALQSYTKWHHIERDPQVFSVKIDEDYVHCLQGVTRASFCNVYLEWIQHCAGKMETPVDSDEDSPLVTLSYALSVLGRRSLGTASHNMSNLESFLYGFNTLFKGDFRIATKDEWVFTDLDLLQKVVAPAVRMSLKLHQDHFTCLEETEEASILYEAITNYRSNLVICHESDPAWRKAVLSSRDTLLTLRHMIDDGTDEYKIIMLYKRHLSFKVIKINKECVRGLWAGQQQELIFLRNRNPERGSIQNSKQALRNMVNSSCDQPLGYPVRKDNLTSCNSGMNMEDVDCGAGGSSSLSHNRPSSVTSNSLSQHRARTAHSHRHQVSSSSSTLSLLFGKRSFSSGLVISGLSAAEGGNTTDTQSSSSVNIAIGPSHRSSSRATQWTSEPYESIDASNSNAAVTVKDDTQLSEQGCSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRS5</accession>
    <name>A0A3P9DRS5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Si:ch211-198a12.6</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551783.1">
        <property type="nucleotide sequence ID" value="XM_004551726.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004551785.1">
        <property type="nucleotide sequence ID" value="XM_004551728.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004551786.1">
        <property type="nucleotide sequence ID" value="XM_004551729.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774716.1">
        <property type="nucleotide sequence ID" value="XM_012919262.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRS5"/>
    <dbReference type="Ensembl" id="ENSMZET00005038447.1">
        <property type="protein sequence ID" value="ENSMZEP00005037149.1"/>
        <property type="gene ID" value="ENSMZEG00005027680.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478961"/>
    <dbReference type="KEGG" id="mze:101478961"/>
    <dbReference type="GeneTree" id="ENSGT00950000183169"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002756">
        <property type="entry name" value="Zinc finger protein 1159"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000597">
        <property type="entry name" value="zinc finger protein 236 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000771">
        <property type="entry name" value="zinc finger protein 648"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000585">
        <property type="entry name" value="zinc finger protein 784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF54">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="387"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="551" mass="62092" checksum="7471FAF49BCD11F3" modified="2019-02-13" version="1">MAESETECDTPGLDTLGSECVIAHSHVDLHYGAETEIMTEEKRGLELEIHGSDLKIQGLGTELGAVACVDAIVAETDHDYIKVEHGDMHCFTGAEIKTTGNEALLGEVLLKTESEHVVKVESDHGGELTVESENGVIIHEAHGLQCNECGEIFGSIADLHQHFEIHKDLNPYICVHCGESFAVEASLKQHMKIHMKEKPYVSPGVEMMGKDVIDAFSLKSHQMIHLPDKPHRCSECGKSFAAAITLREHMKMHSEDKPYKCTQCRKSFVRRRHLKKHQEVHAREKPYTCGQCGKGFATSSNLKQHQKTHAAVVLGDKPHRCAQCGKCFAAAATLREHQRIHSGEKPYKCNMCRKSFVRKRHLKKHQQVHAGGKPYTCRHCNKGFNHSSSLSRHHKTHLQNPVFSPPQPGKPMTYGTPPKQRVHQQGEKPYMCHHCDKGFNHSSSLSRHQRVHSEGKSYTCAHCGKRFNHSSSLARHQRVHLENKQQQQQPQPPQAQQQQYTTIPTGKGFPNNTFPKQRILTVEKPYRCSQCGKGFNHSSSLSRHHRIHVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRS9</accession>
    <name>A0A3P9DRS9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol 1,4,5-trisphosphate receptor-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus outer membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ITPRIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551617.2">
        <property type="nucleotide sequence ID" value="XM_004551560.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRS9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036983"/>
    <dbReference type="Ensembl" id="ENSMZET00005038275.1">
        <property type="protein sequence ID" value="ENSMZEP00005036983.1"/>
        <property type="gene ID" value="ENSMZEG00005027565.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101487932"/>
    <dbReference type="CTD" id="85450"/>
    <dbReference type="GeneTree" id="ENSGT01050000244827"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026250">
        <property type="entry name" value="ITPRIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF8">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02107">
        <property type="entry name" value="INOS145TPRIP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="15">
        <location>
            <begin position="391"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="537" mass="61348" checksum="3131C1CC7DFC8E8B" modified="2019-02-13" version="1">MQGAIARLCVVVAAAILNHPSLFPHENTTLPDQDEELIARMREHEARLEMEKAKLEKELSQMDSKQEETSLQEGYSWYFWSTVSFIIFFTIEMCRVDLADGEVRQVEEEEVFSESGSINPRMMVLDKDILSNFCDKCTYTSAHENWRVREFVEGFADDLLESLRSVCNRDTDMEVGDFVGIGSMFESWKFCKPLTCDLIVPFSPPDPHSFQYHLWCSSSSDIPPDMQGSGKIKVTTPGENSGGCLCGSANLGEDMLCLLHGRNDTPKVSLSPDELLCSRDTNCLAKDQVMKWFQISVTKAWGRISHKYDFDVTFRSLDAAGALKIRFPSGKIIIMNIIPVVQLEDTDAYFVSHFPSDVDSFPDPYWPLSVAVYERNLLKHFSKRLPKHSCHLHCLQIVTFLHKKQSGLTGKSALTNYHLKTALLHLLLSKKTITWSIESMQHRVQDLLSFVQRSLQEKRLNHVMFGNTKVPEEVQVPEMIRRAEPINLFRTLVLQRELYAATVRHFQEMLRNAPVLIQEYTPYLSNGGLHHSLDESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS19</accession>
    <name>A0A3P9DS19_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MORN repeat-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with MYO3A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Filopodium tip</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Stereocilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004555878.1">
        <property type="nucleotide sequence ID" value="XM_004555821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS19"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037239"/>
    <dbReference type="Ensembl" id="ENSMZET00005038542.1">
        <property type="protein sequence ID" value="ENSMZEP00005037239.1"/>
        <property type="gene ID" value="ENSMZEG00005027754.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465866"/>
    <dbReference type="CTD" id="118812"/>
    <dbReference type="GeneTree" id="ENSGT00730000111173"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052315">
        <property type="entry name" value="MORN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46614">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46614:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="146" mass="16172" checksum="8056143CEF23F224" modified="2019-02-13" version="1">MTLTRGSFTYASGEEYHGEWKEGRRHGDGQLKFQDGTCYSGQFENGLFHGSGVLLFTDGSRYEGEFAHGKFHGTGVFSRYDGMKFEGEFKDGRVEGYGLLTFPDGTHGVPRNEGLFQNHKLLKREKCPGVVQRAQASASNAHSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSK4</accession>
    <name>A0A3P9DSK4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Attractin like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567563.1">
        <property type="nucleotide sequence ID" value="XM_004567506.1"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005037434"/>
    <dbReference type="Ensembl" id="ENSMZET00005038740.1">
        <property type="protein sequence ID" value="ENSMZEP00005037434.1"/>
        <property type="gene ID" value="ENSMZEG00005027910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477521"/>
    <dbReference type="KEGG" id="mze:101477521"/>
    <dbReference type="GeneTree" id="ENSGT00940000155790"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000860">
        <property type="entry name" value="Attractin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000079">
        <property type="entry name" value="Attractin like 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Attractin like 1"/>
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        <property type="entry name" value="Attractin-like 1"/>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
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        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
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    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
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        <property type="entry name" value="GBD_ATRN"/>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
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        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF2">
        <property type="entry name" value="DISTRACTED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24972">
        <property type="entry name" value="GBD_ATRN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EGF_Lam"/>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
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    </dbReference>
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        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12 14" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1228"/>
            <end position="1252"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="19">
        <location>
            <begin position="745"/>
            <end position="865"/>
        </location>
    </feature>
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        <location>
            <begin position="1012"/>
            <end position="1057"/>
        </location>
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        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
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    <feature type="disulfide bond" evidence="13">
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        </location>
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            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1041"/>
            <end position="1055"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
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        </source>
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        </source>
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    <evidence type="ECO:0000259" key="16">
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            <dbReference type="PROSITE" id="PS01180"/>
        </source>
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        <source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1378" mass="152357" checksum="D307939DDC4F00CC" modified="2019-02-13" version="1">MDPGRNCKPKLFIFGPKLTIHSDLRGISRYLLVYVLFYFVLVTHASPAKACEKNCLSGKCINGSCVCDRGWVGDQCQHCQGRFKLTEPSGYLTDGPINYKYKTKCTWLIEGYPNAVLRLRFNHFATECSWDHMYVYDGDSIYAPLVAVFSGLIVPEIRGNETVPEVETTSGYALLHFFSDAAYNLTGFEIFYSINSCPNNCSGHGKCTPGNSAASRVYCECDKYWKGEACDIPYCRNNCGSPDHGYCDLTGEKLCVCNDSWQGPDCSLTVPSTESFWVLPSVKPFGTSLARASHMAMVQEKVMWVVGGYTFNYSSFQMILNYNLESGIWNTVPINSGPVPRYGHSLAACQDDIYMFGGKLEAGWENVTDELWVFNVPNRTWQRRNPVVGPPAQAQIYAVEGHSAHCVPLDSGETIMLVIFGYSPIYSYISNVQEYNLRSNTWLVPETKGAIPQGGYGHSSTYDSGSGSIYVHGGYKALPANKYGLVDDLYRYDVNTRTWFILRESGFPRYLHSAVLLSGTLLVFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWTLLPKPDLHRDVNRFGHSAVVSNGSMYVFGGFSSVLLNDVLVYRPPSCQAFLAEEGCVKAGPGVRCIWSRGRCLPWEVRMANSSLTPAPFCPPKAVTMDEWCYRFSDCASCTANTKGCQWCDDKKCISAFSNCTSNVKNFTECPVRNEQVCSKLANCKSCSLNLNCQWDQNHSQCHALPAQQCSEGWNQVGDACLRINSSRESYDNAQHYCKNLNGNIASLTTSKQVDFVLEELKKLQQQDKRLSPWVGLRKINVSYWGWEDMSPFTNSSLRWLPGEPSDSGFCAYLEEPQVSGLRANPCTATAHGLICEKATGNQNQSTRPSCKKPCSLHTNCANCTSQAMECMWCGSVQRCVDSTAYVISFPYGQCLEWQTGDCVAQNCSGLRTCSQCLEQPECGWCGDPTSTGKGLCMEGSFRGPMKRLAKQGQQGPSHDMSLEPGICPKDKGYEWAFIQCPACQCNGHSTCVNGSVCEQCRNLTTGPNCETCMPGYHGDPTNGGKCQACKCNGHASVCQVLTGKCFCTTKGIKGDQCQLCDSENRYLGNPLRGTCYYNLLIDYQFTFSLIQEDDNHYTAINFMASPEQQTKNLEMSINASNNFNLNITWSVGSTAGTISGEEVPIVSKTNIKEYRDSFSCEKFTFRSNPNITFYVYVSNFSWPIKIQIAFSQHGGIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLMRERQQMASRPFASVDVSLEARGEVTEVLQPVLDGAPKPVAMEPCSGGKAAVLTVLMRLPSGPSGLPPPGQSGLIVASALIDVSQQKASDFKEKSLAIKNRKALPPAHQGTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSR0</accession>
    <name>A0A3P9DSR0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SKINT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSR0"/>
    <dbReference type="Ensembl" id="ENSMZET00005038472.1">
        <property type="protein sequence ID" value="ENSMZEP00005037171.1"/>
        <property type="gene ID" value="ENSMZEG00005027699.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244843"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042110">
        <property type="term" value="P:T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000088">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF151">
        <property type="entry name" value="ICOS LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018093915" description="Ig-like domain-containing protein" evidence="11">
        <location>
            <begin position="33"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="34"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="153"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="296" mass="32924" checksum="3FD27E10E7FE4CA1" modified="2019-02-13" version="1">MAHQQDGLFPQPLLKAFSVLIFHILLKDVCNGQPQLIGPSQALVARAGDDVILPCHLEPAYDVSTKTLEWTRSSLDPRFVYVSRASQELEKLKNPSFKGRTSLFVDELKYGNISLKISKVKFADTGTYKCFIPDLEKEALVKLVVASDAATSPIISFSGIDKNRGGVVLQCESAGWYPEPELLWLDGEGNLLSAGPTETLRGPDDLYTVSSTVTVEKRHSNNITCRVQQRNTNQSRETHIHVPEDFFEIPSSSSAVIIGLAVSLALCIMLLILSVVFLVRRKRKHLMSKSLINYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DT08</accession>
    <name>A0A3P9DT08_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">H-2 class II histocompatibility antigen, E-S beta chain-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DT08"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037594"/>
    <dbReference type="Ensembl" id="ENSMZET00005038904.1">
        <property type="protein sequence ID" value="ENSMZEP00005037594.1"/>
        <property type="gene ID" value="ENSMZEG00005027279.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183127"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000353">
        <property type="entry name" value="MHC_II_b_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF99">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1 BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00969">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00921">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018204396" evidence="7">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="257" mass="29162" checksum="7CA8C0B797B9BEA5" modified="2019-02-13" version="1">MASSFLCLSLLFISFSTADGFKMFVVSRCDFNSTELKDIEYMRSYYYNKIEVTRFDSNVGEYVGYTDFGVKQAKHFNSIPGQLATLRAQKETYCHNNIGVWYSNPLSKSGECPYVKLHSMTPASSHHPAMLVCSVYDFYPSKIKVSWLRDGQEVTSDVTSTEEMADGDWYYQTHSQLEYTPRSGEKISCKVEHASLEKPLITDWDPSSSMPESERNKLAIGASGLILGLILSLAGFIYYRRKARGQSRTLTHRPVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DT81</accession>
    <name>A0A3P9DT81_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin/ISG15 ligase TRIM25-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DT81"/>
    <dbReference type="Ensembl" id="ENSMZET00005039344.1">
        <property type="protein sequence ID" value="ENSMZEP00005037945.1"/>
        <property type="gene ID" value="ENSMZEG00005028371.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286922"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29235" checksum="76E6B6AECD218B6F" modified="2019-02-13" version="1">MGELDRETISCSICLDLLKDPVTTACGHSYCRNCIKSFWDEEDRKGIHSCPQCRKTFIPRPVLEKNIMFAALVEQLKKTGLQAAPADHCYAGPEDVACDVCTGRKLKAIKSCLVCLASYCEKHLQPHYESQAFKKHTLVKTSVKLQENICSRHDEVMKIFCRTDQQSICYLCTMDEHKGHETVPAAAERTEKQKELEVRRLNIQQRIQEGEKDVKLLQQEVEAINETQISNQRVKSAVHTHVKLQPPPLVSVTLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTM9</accession>
    <name>A0A3P9DTM9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin binding LIM protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTM9"/>
    <dbReference type="Ensembl" id="ENSMZET00005038933.1">
        <property type="protein sequence ID" value="ENSMZEP00005037623.1"/>
        <property type="gene ID" value="ENSMZEG00005028059.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182850"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09327">
        <property type="entry name" value="LIM1_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000055">
        <property type="entry name" value="Actin binding LIM protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000003">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000024">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF18">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="351" mass="38720" checksum="EA9D96F0D72F08F4" modified="2019-02-13" version="1">MLLMDSCHPCPPAGKKVICCFRCGESCRGEVLRVQSSYFHINCFTCKVCGCDLAQSGFFMRNGDYLCPLDFQRRHGTACNSCGEFVEGEVVTVLGKTYHPACFVCAICKQPFPAGNCVTFIGRDCLCQRCMEPVSPSPNATSYSSNCTGCGRDIKNGQALLALGGQWHLGCFKCKTCRKALSGEYISKDGVPYCERDYQIQFGVKCEACQKFITGKLLEAGDRHYHPSCARCSQCDRMFTEGEEMYVQGQFEIQTRSSSESSCSRPGSCTPGSPGRTICAKVDNEIIDYRDLAAIPRVKAIYDIEYPDMISYKSVNDHPSTLDEKGNTQHSQRVQKSPAEVITSNAPTCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUB9</accession>
    <name>A0A3P9AUB9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Linkage group 5 C1orf158 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Microtubule inner protein component of sperm flagellar doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUB9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001294"/>
    <dbReference type="Ensembl" id="ENSMZET00005001384.1">
        <property type="protein sequence ID" value="ENSMZEP00005001294.1"/>
        <property type="gene ID" value="ENSMZEG00005001080.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177901"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054709">
        <property type="entry name" value="CFAP107"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037662">
        <property type="entry name" value="CFAP68/107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31180:SF2">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31180">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22595">
        <property type="entry name" value="CFAP107"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="196" mass="22678" checksum="E847426242B0FA23" modified="2019-02-13" version="1">MNQKANAQDKWAQTGWRIEQKYANKVLLGNWAEERLQVGILSVYDISLYIVIQGLPSKTIFGHHDQPSSHYLVTQYAESYGRNLINALPTLQHRHADNLTQKPERSDQLTSGKFHTTNHHFEIQQSHLPSLTEYRSAYQRQPLSAFCQSRFAKASHMLSSHLYEANRNNKDLDLRQHLILQVPDHYFSLCPPSQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUR6</accession>
    <name>A0A3P9AUR6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cadherin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUR6"/>
    <dbReference type="Ensembl" id="ENSMZET00005001526.1">
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        <property type="gene ID" value="ENSMZEG00005001191.1"/>
    </dbReference>
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            <end position="26"/>
        </location>
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            <end position="122"/>
        </location>
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            <end position="66"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
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</entry>
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            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
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                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_004562924.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AW29"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001901"/>
    <dbReference type="Ensembl" id="ENSMZET00005001996.1">
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        <property type="gene ID" value="ENSMZEG00005001531.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484911"/>
    <dbReference type="KEGG" id="mze:101484911"/>
    <dbReference type="CTD" id="65264"/>
    <dbReference type="GeneTree" id="ENSGT00940000159091"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000046">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="144"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="403" mass="43333" checksum="CBC0086092EC7BF5" modified="2019-02-13" version="1">MADSFGDESSSSALGLDVTTGQGSGASQLPILSNSLSVGMSATGGVHSSSNPTSPPLAVAAQSGLTAVVAPMSAVTATPVSFGNTLTPGSSPPVVAVSPTLHASSPLPGVGLGAAGAGLLSQINATSWDPTLSTDWDNEKASQQCILRIKRDIMSIYKEPPPGMFVVPDPQDMTKIHALITGPFDTPYEGGFFLFLFRCPPDYPIHPPRVKLITTGHNTVRFNPNFYRNGKVCLSILGTWTGPAWSPAQSISSVLISIQSLMTENPYHNEPGFEQERHPGDSKNYNECIRHETMRVAVCDMLEGKVLCPEALLSVMEKSFLEYYDFYEGVCKERLHLQGQNMQDPFGEKRGRFDYQGLLARLGATHRRLREKNLAEDNHNDNDSDSDTSSSGTDPDSQGSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AW96</accession>
    <name>A0A3P9AW96_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VWFD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
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                <person name="Carleton K.L."/>
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                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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        <property type="match status" value="1"/>
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        </source>
    </evidence>
    <sequence length="875" mass="97037" checksum="4DD3263A8C5967C3" modified="2019-02-13" version="1">MSFLMKARLVLFSLLWTGIFAYDSYQDQCEIIPGTMSLPALEKKGDIILGGLFSLHDMVVEPSLSFTSTPPSTQCTRFNFRTFRWMQTMIFAIEEINRKGNLLPNITLGYKIYDSCSTPHQALKAVLELRGTENNSAGNTHQQGVCHESIPAVIGDGGSTQSLVVAHFLGVFHVPQVSYFSSCACLSDKNKFPAFLRTMPSDFFQVDALLQLVKHFGWTWVGVIAGDDDYGRGGANIFVNEVTKLGACVALHEIIPKNRAQSTISSIVSNIQSSGVWVILVFAVEQDAAALFDEVLRMELAGIQWLASEAWSTAAILSTPRKYHHILQGSMGFAIRRADIPGLRDFLLRLNPLSSDASNDPFLAPFWEEVFQCSLGVEAEDQKYNTEGNPPCSGTEELGSIANIYSDVSQLRISYNVYNAVYALAHAIKAMRSCVKGKGPFLQQACPDMDSIKPWQLLHYIKQVKYFNTFGDETKFDGNGDPRAMYDLVNWQLKPNGKMDFVTVGKFDETTAASHHKLQIQEENILWTGNQTKVPLSVCSNVCPPGTRKAIRPNFPICCHDCVVCAAGEINAIECIQCLPEFWSSAEKTACIPKQMEFLSFSDTMGIILMVISLTGIFSTCFVAFIFYCHRSTPIVRANNSELSFLLLLSLTLCFLCSLIFISQPSKLSCLLRHTAFGITFVLCISCILGKTIVVLIAFKATLPGSHVIKWFGPLQQRIIITCCTLVQVIICTVWLVVAPPMPQKLMPRDSPIVILLCDKGSHLAYALVLGYIGLLAFLCLVLAFLARKLPDNFNEARIITFSMIIFCAVWIAFIPAYISSPGKYSTVTEVFAILASSYGLLGCIFAPKCYIILLRPEKNTRKHLMSKTSTSKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B158</accession>
    <name>A0A3P9B158_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="RefSeq" id="XP_004539219.2">
        <property type="nucleotide sequence ID" value="XM_004539162.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004539220.2">
        <property type="nucleotide sequence ID" value="XM_004539163.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004539221.2">
        <property type="nucleotide sequence ID" value="XM_004539164.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004539222.2">
        <property type="nucleotide sequence ID" value="XM_004539165.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012773634.1">
        <property type="nucleotide sequence ID" value="XM_012918180.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012773637.1">
        <property type="nucleotide sequence ID" value="XM_012918183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B158"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003620"/>
    <dbReference type="Ensembl" id="ENSMZET00005003772.1">
        <property type="protein sequence ID" value="ENSMZEP00005003620.1"/>
        <property type="gene ID" value="ENSMZEG00005002804.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005003779.1">
        <property type="protein sequence ID" value="ENSMZEP00005003626.1"/>
        <property type="gene ID" value="ENSMZEG00005002804.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477210"/>
    <dbReference type="CTD" id="197370"/>
    <dbReference type="GeneTree" id="ENSGT00390000009084"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000270">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.220:FF:000001">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0779">Telomere</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="19">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="247" mass="28869" checksum="E338A306BCD924C1" modified="2019-02-13" version="1">MSRQMGESHRRFLQTMMVSGVIDEQAAKALYQYCCETHHTQYAPDKLEDFIDTINSRLQPMFMQIRKGMSENNGLQYYALVNMAETDITRMSSDYADNELELFRKTLDLIVCSENGKASSTDILNSTDSMTTRKMKKSETEHLLSRLVHDKWLSEKRGEYTLSTRCIIEMEPYIRTMYQDHIKVCHICRNIAFQCQICENPTCGIKIHNPCVARYFKGKSEPRCPSCDDFWPHEIPEVKRPHSQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B348</accession>
    <name>A0A3P9B348_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerases I, II, and III subunit RPABC4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-directed RNA polymerase II subunit K</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549235.1">
        <property type="nucleotide sequence ID" value="XM_004549178.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B348"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004187"/>
    <dbReference type="Ensembl" id="ENSMZET00005004361.1">
        <property type="protein sequence ID" value="ENSMZEP00005004187.1"/>
        <property type="gene ID" value="ENSMZEG00005003220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476521"/>
    <dbReference type="KEGG" id="mze:101476521"/>
    <dbReference type="CTD" id="5440"/>
    <dbReference type="GeneTree" id="ENSGT00390000008918"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="58" mass="7002" checksum="239BA3B7B1ECBE4C" modified="2019-02-13" version="1">MDTQKDLQPPKQQPMIYICGECHTENEIKARDPIRCRECGYRIMYKKRTKRLVVFDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3J6</accession>
    <name>A0A3P9B3J6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004570700.1">
        <property type="nucleotide sequence ID" value="XM_004570643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3J6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004466"/>
    <dbReference type="Ensembl" id="ENSMZET00005004668.1">
        <property type="protein sequence ID" value="ENSMZEP00005004466.1"/>
        <property type="gene ID" value="ENSMZEG00005003491.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471452"/>
    <dbReference type="KEGG" id="mze:101471452"/>
    <dbReference type="CTD" id="100151027"/>
    <dbReference type="GeneTree" id="ENSGT00940000153956"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000453">
        <property type="entry name" value="Ankyrin repeat domain 1a (cardiac muscle)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000111">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="312" mass="34564" checksum="1341DB9F169EFC71" modified="2019-02-13" version="1">MGLLSVEELVTGKRSEGIEADDFQGGVYEAAVNQEKRDDLRSHGELGVGGRLSEESDSGSEQEEVSVAALNTDRSGRLKLETVDDLFNILQLRKKRRERKSPVLKKDEPEPETVPETVDEELFLTAVMENKLAVVEKYLSDGGSPDASDNFQRTALHKASFKGHVEVMQRLLEAGAAMEKKDKLEATAVHWACRGGSLPALQLLLDRGAKFTSRDKLHSTPLHVAVRTGHCDCAEHLIHCGADLNAKDRDGDTPMHDAVRINRFKMIKLLMMYGASLNTKNSDGKTPMETLYSWQNGAKSLLCNFSEEKLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B4Q5</accession>
    <name>A0A3P9B4Q5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
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    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004881"/>
    <dbReference type="Ensembl" id="ENSMZET00005005095.1">
        <property type="protein sequence ID" value="ENSMZEP00005004881.1"/>
        <property type="gene ID" value="ENSMZEG00005003727.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157700"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001045">
        <property type="entry name" value="Microtubule-associated serine/threonine kinase 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF150">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-0418">Kinase</keyword>
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    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
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            <end position="607"/>
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    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="19">
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    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="1071"/>
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        </location>
    </feature>
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        <location>
            <begin position="1278"/>
            <end position="1538"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
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            <begin position="26"/>
            <end position="35"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="16">
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            <begin position="36"/>
            <end position="47"/>
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    <evidence type="ECO:0000259" key="18">
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    <evidence type="ECO:0000259" key="19">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B517</accession>
    <name>A0A3P9B517_9CICH</name>
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            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_004561802.2">
        <property type="nucleotide sequence ID" value="XM_004561745.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023008890.2">
        <property type="nucleotide sequence ID" value="XM_023153122.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024659714.1">
        <property type="nucleotide sequence ID" value="XM_024803946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B517"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004991"/>
    <dbReference type="Ensembl" id="ENSMZET00005005214.1">
        <property type="protein sequence ID" value="ENSMZEP00005004991.1"/>
        <property type="gene ID" value="ENSMZEG00005003844.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101466073"/>
    <dbReference type="CTD" id="23305"/>
    <dbReference type="GeneTree" id="ENSGT00940000154508"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF54">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="141"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="722" mass="80489" checksum="782D2F2551EC92EB" modified="2019-02-13" version="1">MLAFVLVSGSLWIILELSSTLMEKMQAQEMMSGLRIPEMDELGQFFRSLPTSTLVGIGALTAVLAYWLATRPRPIKPPCSLLHQSEEVPHEDGGRRSMMGDPSKLLTHYHDDAKTMYEVFQRGLHISGDGPCLGSRLPNQPYKWMSYKEVTARAEHLGSGLLHQGCQPNPNQFIGVFAQNRPEWIISELACYTYSMVVVPLYDTLGQDAIRFIINTADISTVICDKMDKARVLLENVERKETPGLRRVILMDAFDSDLVEQGKGCGVHVQAIKEVEALGRDHYRKPIPPSPDDLSIVCFTSGTTGNPKGVMLTHGNVVADFSGFLKVTDKVIFPNQDDCLISFLPLAHMFERLIESVVYCHGGRIGFYQGDIRLLPDDMKALRPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLNFAAKRKGAEVSSGIIRSDSVWDKIFFSKIQASLGGRLRMIITGAAPTSPTVLGFLRAALGCQVYEAYGQTECTAGCTFTTPGDWTQGHVGAPLPCNLIKLVDVPEKNYFASKGEGEICVKGPNVFKGYLKDPERTAETLDADGWLHTGDIGKWLPNGTLKIVDRKKHIFKLAQGEYISPEKIENIYIRSEPVAQLYVHGDSLQSCLVGIVVPDPETMPEWAKKKGILGTYEDLCKNTELKKGILEDLVRLGKASGLHSFEQVKNIYIHNEMFSIQNGLLTPTLKAKRPELKEFFKAKIDELYNSISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5I8</accession>
    <name>A0A3P9B5I8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5I8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005145"/>
    <dbReference type="Ensembl" id="ENSMZET00005005370.1">
        <property type="protein sequence ID" value="ENSMZEP00005005145.1"/>
        <property type="gene ID" value="ENSMZEG00005003988.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000170012"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018309810" evidence="2">
        <location>
            <begin position="22"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="266" mass="29219" checksum="9319F73670374585" modified="2019-02-13" version="1">MTSFCRNLVALVFLVLPPMHSHFFTNAASASPPITRPQIIHMTDMGSEGQDDYDFNKGEYDTTTASPRMVSFPKMDLEPLLCEYDPCSENQVPCAALSEQIGCLCPGMSGANVPPHPPRIQALVPVSAGSDRGEIQVQCCAPSSVVSEYRIVIEGRDSEVPKFGDASRRGLVRSLEVGTKVCVVAVNNAGSRDPSEFSCKRYECRQSPVLTVMAWIIGGLFALPLLVCMKLMCMDIKKCRNDAFSSPSYCFHTGNNEVSYLFQQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B818</accession>
    <name>A0A3P9B818_9CICH</name>
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        <submittedName>
            <fullName evidence="14">Envoplakin</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the plakin or cytolinker family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563063.2">
        <property type="nucleotide sequence ID" value="XM_004563006.3"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005006048"/>
    <dbReference type="Ensembl" id="ENSMZET00005006323.1">
        <property type="protein sequence ID" value="ENSMZEP00005006048.1"/>
        <property type="gene ID" value="ENSMZEG00005004706.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101470648"/>
    <dbReference type="CTD" id="793139"/>
    <dbReference type="GeneTree" id="ENSGT00940000153578"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Periplakin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000088">
        <property type="entry name" value="Periplakin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.780:FF:000001">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000002">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058847">
        <property type="entry name" value="Plectin_PPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055419">
        <property type="entry name" value="Spectrin_PEPL/EVPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF7">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00681">
        <property type="entry name" value="Plectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26346">
        <property type="entry name" value="Plectin_PPL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23160">
        <property type="entry name" value="Spectrin_1st_PEPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21097">
        <property type="entry name" value="SR_plectin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="391"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1772"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="652"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1011"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1249"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1374"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1464"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1778"/>
            <end position="1801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009109"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006048.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2038" mass="234102" checksum="EDFC5FAB642A5129" modified="2019-02-13" version="1">MSKKQDPSTVKLNKTQAQELAVLISRMQKNADQVEKNILQAEKLLAVDKERKGNNEQLLHKKENADNLAQAEGLLKDLFMDVGGAKKLQHPQAKEIEKDVVNLHYRWAKDCATFREVYESVQDVDLTQKIGWGPLFDERLKQLRAEAYGPKLSDVERQIAAHNLRHQEIKAYQDQLKPSTTLSQEQYAAVKEKYAELFESSERRRNHLASLYEYMQSCSKELIYLSNQQDRILQRDWSDRMVDPPSVRMEYEKFKANGLLAHEQEVNQLQEEGDNLIKMKHPGSPTIKAHRDTVQAEWQAFLNLCLAQEVHLDNIDNYKKFQLDAERLSESLERLSSTLDSKSMENKTNPEILLALEGDEPAVKRNEQRLAALRELSDSVVPLKLRRMQLSKPTTVISLCDWIDEEGAVRRGEKLTLKSSSDNNNWKLQDSSGKTKTLSAACFMIPPPDPEALETVNSLDRQLADLKRRRSALIASLKSPAVEVIQTQKRVAVKSPENPRVAELLSELGKINKALEALEKEILRRARTPLDNRNPTQDLANRLQEHEKSALAVKKLESEKSAIQREVDPILAKKPLGPTASALPPKLSATNKKFDDINALIDLYNKKATASMYLEKEIKNVEGVVSGFEKELAKDGTILDQPNSLQSRNQKLQAMSKDVASKKDELKKLGKELDLTEQACNSLQQNLNEYCPDIRRQEDQVKNLKNRYTRVNSQLQERSALVQQAVNKNQDFQSAVQSLDFFLVNLPDNKIKPTDGVAQITSKENSQKRVVEDIKKKSGDLNRVKDLSRNLQNVLNDYEIKSNTYSAILTDDDGADESEEDVDEEPVSLKRQTSTLSQAIQRTEKDLLNHFAEVSAENNQLLNQLGTTKNIMAMNEEKISQVAVTQQLQLQSQMKDQEQSDSLKKELSEEVNRRLHAENNLDTYRKRFMSLKNRRGVERLEEKEVVQYYRDPKLEMELKSLKSRIEDEELKRSGTKTEIEINNEKIIKLELQLTKVEPKLVTKILTEYEKDPQLDKEAAKLRDEIQRLRLELQTRNTEAVQVKKEITVLAQQKPKIIEKVVKKEVVRLEKDPEMLKAVLLFQSDIAEEEYRCKALNDHIFSTRSQINTLERVIPTIQPKVITKVVSQVRQDPETVEESNKLRMTLEEEKDENVILMKDLTTLQLRYSELENLRPKVEVKEIINEIYRVDPETEVEMIRLRKELQDSSQNRTDTEKEIDTVTKTLVTLRAQKPKVEYKEVTQEVIKEEKSPEVIRELQRLNNQMNRLQVNYDTTIELLTHLRKERDELKAEKTKVETQLVNKEVINYENDPLLEKEADRLRRNLREEIQQRRSLEECLFDLQNQHITLERQKPQEKILTQEVVRLQKDPKQILEHEKLNKKLDDETKTRRKLELEVRQLRALIQDKEIMLAQLDDRQKKIQVESELRQIKARILELENTPPPIEERIIVEEVLKVEKDPQLDKLIGSIHDNLETEGNEINRLEREIRNIKLKLETLQKEKSIEKVVYREVVRVEKDPAVEAEREQLRELVTKERNLRRNQEDNIQSTHLKMTHLQTSRSVTSQEETTLISIRDALQRDKEDLLKQFKTLESQRQSISITFQQQSKLMSERNLTVRQRSLKTSSEIQRLEKEILKEKDKIHEKDKLIIEMLDKIKHEDHSKTREANLSTKITIFDPETGKDLSPYDAYLQGLIDRNQYIKLSELECDWEEITSSGPGGDTIILHDRKSGNQYSVRDALREGRLTQRDVSRYKEGKMPISEFALLVAGERSKPYVPPLMPKSPTKTIPTAPTKPISTSPLSSMSSSLRSSYTNLNTQYSGSLGSLTNLSALPGDEFFPISGIFDTTTESRMSVRSALTRGLIDADTALKLLEAQAATGGIVDLGKKDKLSVHKAAEQGLIDTNQKYKLLNAQKAFTGVEDPVTKQRLAVGQAAQKGFIPQENARRYLEAQYLTGGLVDPTKAGRLTIKEALATGLIDSTTAKDLQDEASHTKELVDPISKGKISYKQAMDLCRKDFSTGLLLLPATSTDVANAPSYSNFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8T5</accession>
    <name>A0A3P9B8T5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8T5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006262"/>
    <dbReference type="Ensembl" id="ENSMZET00005006551.1">
        <property type="protein sequence ID" value="ENSMZEP00005006262.1"/>
        <property type="gene ID" value="ENSMZEG00005004862.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156922"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000116">
        <property type="entry name" value="Transcription factor 20 (AR1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052440">
        <property type="entry name" value="Trans_Reg/Chrom_Remod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14955">
        <property type="entry name" value="RETINOIC ACID INDUCED 1/TRANSCRIPTION FACTOR 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14955:SF8">
        <property type="entry name" value="SI:CH211-165G14.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="116"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="228" mass="25076" checksum="866A7B79356A7F16" modified="2019-02-13" version="1">RGHSYEYKFKQRPLICCLCGQSANAMDLGDLHGPYFPEGYQPSTKKPASTLGLKEDDYSDSDSSSCSMRGRGRKCAAVPAVRALRPGAQLKKRGLIENHRWNISTIGTGSPAAKRVRSDASSANVEDWYSPPMLLLQPCEYWLHEDCGIWSAGVFLVKGKVYGLEEAVKVGQETTCSACNDPGATLGCFFKGCPNKYHYRCALESDCVLIEENFSMKCKKHKVSSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9X9</accession>
    <name>A0A3P9B9X9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Granzyme B(G,H)</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9X9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006718"/>
    <dbReference type="Ensembl" id="ENSMZET00005007018.1">
        <property type="protein sequence ID" value="ENSMZEP00005006718.1"/>
        <property type="gene ID" value="ENSMZEG00005005110.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144271"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF87">
        <property type="entry name" value="ARGININE ESTERASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="99"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="330" mass="36813" checksum="4014CCCF54EA95F2" modified="2019-02-13" version="1">MSFNTHIKQICKTAFFHLRSISKIRNILSQSDAEKLVHAFITSRLDYCNSLLSGCPKTSLKSLQLIQNAAARVLTGTRKREHISPVLASLHWLPHGSDIINGEKAPENSSHYMASVQNKKGQHVCGGFLITEDFVVSAAHCDEYNPTDVVLGNHNLKNDNHQKIKIKNKNIRENYQNIGQGNDIMLLEVSTCSCVQLNERVQTIQLPPAEIHLEENQVCQVAGWGKTKTRGKSVDELRVVDVSVINQRVCEEQWPGLPANVICAGGYKTTKGFCQGDSGGPLLCDGLAVGVVSFNYKENCSYPNKPNIYTDISKYRQWIDGIVKSRKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BA68</accession>
    <name>A0A3P9BA68_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Muscleblind-like splicing regulator 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the muscleblind family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012773128.1">
        <property type="nucleotide sequence ID" value="XM_012917674.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BA68"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006767"/>
    <dbReference type="Ensembl" id="ENSMZET00005007067.1">
        <property type="protein sequence ID" value="ENSMZEP00005006767.1"/>
        <property type="gene ID" value="ENSMZEG00005005200.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470482"/>
    <dbReference type="CTD" id="55796"/>
    <dbReference type="GeneTree" id="ENSGT00950000182897"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000004">
        <property type="entry name" value="Muscleblind like splicing regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000002">
        <property type="entry name" value="Muscleblind-like 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF3">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="349" mass="37987" checksum="F7063C905FD7E2EB" modified="2019-02-13" version="1">MAVSMTMGRDTKWLTLEVCREFQRGTCSRSDAECKFAHPSRSCHVENGRVIACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKAAAAMLAQQMQFMLPGTQLQPITTFPVTPSLATSPSMAFSPYLSHMGPAMGLMPELLPSTPLLVPGSPTGLAAMGNGTSAQKHVRTDKLEVCREFQRGNCTRGENDCRYAHPLEAGMVDCNENSVIVCMDYIKGRCSRDKCKYFHPPAHLQARIKAAQHQAGQNTPSSGLGLPPGAMQPLPKRPVLEKSNGAAATVFNPSMFHYQQALANMQLQQPAFIPTVPMMHGATTSTVSSASTPVTNVPFAESAASNQTPRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAX6</accession>
    <name>A0A3P9BAX6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544150.1">
        <property type="nucleotide sequence ID" value="XM_004544093.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAX6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007037"/>
    <dbReference type="Ensembl" id="ENSMZET00005007344.1">
        <property type="protein sequence ID" value="ENSMZEP00005007037.1"/>
        <property type="gene ID" value="ENSMZEG00005005399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487425"/>
    <dbReference type="CTD" id="51433"/>
    <dbReference type="GeneTree" id="ENSGT00390000018674"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16270">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048968">
        <property type="entry name" value="Apc5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21371">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5 N-terminal" evidence="20">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="19">
        <location>
            <begin position="266"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="19">
        <location>
            <begin position="604"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="771" mass="87011" checksum="6E13E42B8CF947C5" modified="2019-02-13" version="1">MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKISVLALLYEMTASKITLPERRRLNKLILPLQQGPDLTLGQFLKTVEECCPQTAYAVKLRLHEMADGELKDMEYFFSTLPTPFTAFDTEAYKTSVVGLFMRHMLLAYNKLSFSQVYKLYKSLQHYYHSHYAKPMDGQVPALVADDSEMDLTSIEDTVGDRVDKEELDTPLHESELQSDNTPSRGPLSQKQAEYFLARQAYLLKNDENKALKPAALQEELNNMLKFNPDFAEAHYLNYLNSMRVQDIFLSAHSLLHYFDRLILSGNDGKSNGDEGYGRSLRYAALNLASLHCRFGHYQQADLALQEAIRIAQESNDHVCLQHCLSWLYTLEQMKGSDSTVLTEDSVKMAAHFCLPYLASLGIQSLVQQGATQGKTAHKLMDALKDTDILHWKHSLSELIEISLAQTTSIWRMYGKSTMSLQQAQLLLNMSSLEPVNFGVQQNNTEGFAVVLCHLAELHAEQGLYGVVSEIILHLKEQFPPHTQHAKLWMLCDLKIQFERHMNEGKYHLAEPLVTAIAALNQTEGLYRKAQVLKALNRNTEAYHILQQLQARCEKAKCTEMVIRVMLSTAELHWESSGFSTALPVLLQALALARQHHLQSLASETILHLAFTQLMLGVPEQALNVLHEAIEPILAHRAVMDKGRAMLLAARCQMAVAGFKPNRQGQADLCLAASALDTLNEAAAYFSQLNCKERLRDVHYLQAQLHRSLGQILESNKSAMLFRLLDQELQSPAPPVSMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BB16</accession>
    <name>A0A3P9BB16_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Testis expressed 10</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004541435.2">
        <property type="nucleotide sequence ID" value="XM_004541378.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004541436.2">
        <property type="nucleotide sequence ID" value="XM_004541379.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BB16"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007090"/>
    <dbReference type="Ensembl" id="ENSMZET00005007398.1">
        <property type="protein sequence ID" value="ENSMZEP00005007090.1"/>
        <property type="gene ID" value="ENSMZEG00005005459.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481791"/>
    <dbReference type="KEGG" id="mze:101481791"/>
    <dbReference type="CTD" id="54881"/>
    <dbReference type="GeneTree" id="ENSGT00950000182992"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000164">
        <property type="entry name" value="Testis-expressed sequence 10 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057949">
        <property type="entry name" value="TPR_TEX10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25781">
        <property type="entry name" value="TPR_TEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="134"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="TEX10-like TPR repeats" evidence="8">
        <location>
            <begin position="557"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="943" mass="105148" checksum="8CA37978318C1F2E" modified="2019-02-13" version="1">MKAKKKKRQDDFQKVKLKVGKKKPRADNATNTNFRSKGIYLSEQLKRDTSGPTTHKQLGINDLLSQLHHYNANVKHSALLGLKELLSISPSLLEQHLSRLLSEVAAVLTDKDHNVRVAAARVLRYIAQCVPAERVAPFFPLLSAHLSCAMTHIETGIQEDAINVLDVFLEHYPALLAARPAVLLTNFLEMISHRQNSGGAKKASDSKAWTWALSINPNRAVTSQQWRLSVLLRLGRFLQAVVEERPTEESDMSVPTERVFGSSGEGRFTPLHLNWEELTYSKVGVKIYEHSGAKPTPHSTFKLRPEQDPGATVSEGLDSAETVQKFAATLVPLLLEVWVEASTNDSPWNNTEGAHLLTPDAMSVMFQVLSILQLLRKLAPQRENQDALDAWFRKEYLGDFKQHFIKNFPYGSRDTPRHKKKIDLKRSKQTAALPGPTVDPLALNITLCQVMVSLSQKQGVGQEADGDWLTPLSTFVRDTLGSGVKLSYRQLQMLLGTVWKMVLTQRSKTVTEDLLAAVYIYYKQRNLPLQTRSLLLSFYSKLYLQEQGHAHLTRSKVLSRWLASLPVQLSQLGHRNPMLSAQLILSIQAAASRGNKDLLSSLQTHACTLYDPQDGVVVLLPSESQQRMVQLLYFLPKMSQPLLANLSSCCTAGRISAGLAASLIRIIHLRSPLSSWTAGSQEAALQHVDYFSFLFSTLIGFSSEQLASLQEAEDDSVLPPVALSPLSLYPTPLEQFTHHWDIVEEVCHCLETLGSKSQCFDILQTGICNYLTKLEVVSDSMAAGLLRAVSRLLDLSVLPLEPVLRFLSQCCLSLLSLLLTLQQEAPTETNHKREAIWGACVTALSSIPRLLRVVLQSLRVANLNEEELPQLGQILSMLLQHTSLHSQLLANTTLLQEILQHLTRFSRGATREQWLTDLLYCYSVTVAHGSSAHRGNLGLRDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD44</accession>
    <name>A0A3P9BD44_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Plexin-B1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014264162.1">
        <property type="nucleotide sequence ID" value="XM_014408676.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014264163.1">
        <property type="nucleotide sequence ID" value="XM_014408677.1"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005007845"/>
    <dbReference type="Ensembl" id="ENSMZET00005008163.1">
        <property type="protein sequence ID" value="ENSMZEP00005007845.1"/>
        <property type="gene ID" value="ENSMZEG00005005923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475072"/>
    <dbReference type="KEGG" id="mze:101475072"/>
    <dbReference type="CTD" id="570222"/>
    <dbReference type="GeneTree" id="ENSGT01150000286928"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12793">
        <property type="entry name" value="RasGAP_plexin_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000131">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000010">
        <property type="entry name" value="Plexin B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000012">
        <property type="entry name" value="Plexin B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000126">
        <property type="entry name" value="Plexin B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000705">
        <property type="entry name" value="Plexin B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000120">
        <property type="entry name" value="Plexin b1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000203">
        <property type="entry name" value="Plexin B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057533">
        <property type="entry name" value="PSI_Plexin-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF36">
        <property type="entry name" value="PLEXIN-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24317">
        <property type="entry name" value="PSI_Plexin-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1600"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="19">
        <location>
            <begin position="28"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="750"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1386"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1545"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1389"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1546"/>
            <end position="1555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2241" mass="249100" checksum="DD2059C21EA5F317" modified="2019-02-13" version="1">MPLGMVRLSLSAVKTLLSLLLLATGCPLILFPIGTVQGSDSFPSNFYPTFIRNDTLFEHLALHPDPDVGRVYVGARNRLFQLDPFLQPELQDDTGPVTDSRDCLPPVTETNCPQARETSNHNKLLLVNPYSMELITCGSVNQGICQKRSLDSVDQVLFSTERPVDTQYVAANHPNVSTVGLVVRSHPDKQPVLFVGRGYTSSHPPISTRNLAQDPIFSYEETAKLAVAGRLSEYDHNFVASFAHRQHVYFLFYRRDLKSPSREYRTYISRVCLDDQAYYSYVEVPLTCRSRTGKIYNLLQAVQLGVSKEDVGGQGSETLVGVFSTRLASTRPSEESALCVFNLEDVDRRINSTRDFCYTQMGKEAGVEAAYIEYDVKSNCANLPENTLDAYPCGSDHTPSPMASRIPVEVETILDSPSARLTAVAVSSRVGHTIAFLGDSKGNLHKVFLGPNGEVEEYSVTPIQKNAAISSDLILDQKQEHLFIMTHNMLQKRPVAECQQHPDCHSCLLAHDPYCGWCVLEGRCVLQSQCARGSYPGQWLWSFDMEQQCLVVQDLVPSNLSREESKMVSLSIPRLPVLENGESYSCYFQDSHTPATITETGVTCRSPDTSRVPLVFRGQDFVTVTLSLRFGNVTVTARDFTFYDCTAVKQLSGSQPCRGCVLSRWGCNWCVHQHACTHKPTCEEGVIIYNQHFKLPTSSPPTTKAIKVITATTTTTATPTTPPTTPTTATTKTTTTTAAAITIATTKELTTPTLSYTSTSHEPTHPGTTLPPQPPTLPPSTSPGLEVTTREEEESEASETVTHSDWEDAVATQSVTMATAELMPVTVADGLSGDLDPVVPLMIPDSSPPEVVTALPPSERQAAKEALTLAEAPTMVLPGFPPPTLFHMGEPADSEPSLYLDSTQTPTLVPPQDLHTEAGSPTADSEVPLWRKEAENYTEGAVQAENDTATFSAATVLSGDGEVDRMSQSYPPQLLNADSELDYQYDSADGFLPGDEGSYVSWGSSACPCVEKVQGSSLLPVRVERKITLLAHNLHLYQDAELDYECVLVIEGQTVVVDAYVEPDDMNPSSFDITCQLHQYTYSAPVQEYNALVYVKRRDTFHVDTSRDLYVTLYNCSVGRSDCSRCHTADPKYGCAWCGGPRASCLFSNSCSEPVQQTCPAPVIHSVDPLSGLLEGGTMVTISGSNLGQKAEDIVQSVLVADVPCTVISNLYEVSSRIVCMTKASGLKTNHVSVRVNGGEFGLSRQKFSYQNPVVRGVSPERGPKAGGTSLNITGQNLLTGRPADLTITVGDVPCNIVSEVQSDSVQCVTGSSNKTGDHQVTLHYGSIQRHLSSPAYHYTNNPNITRAEPARSFLHGGRLIKLSGSNLDVVQEPRMVVTLSRFQSVGQNKKRKRRRKRSKGEQWKKTLGRSVRMVPDPVCPGDQFCSVKQFVERCEVNSSSLILCRSPMVDSTIWWSRVTVEFLLDNLRFDFSSLNSEPFSYERNPTLQPLNQQDPLKAYRYNPGSFIQLEGEHLDLAITKEEVVVLIGEGVCAVKTLTSNHLYCEPPPQQPAPGPNGKKREGSDNLPEFTVQMGNLNFYLGKVQYDNLSLSTFPLEAQIGVGVGASIVVLIVLIIVLIYRRKSKQALRDYKKVQIQLENLETSVRDRCKKEFTDLMTEMMDMSSDLVGSGIPFLDYRMYAERIFFPGHRESPLRRDLDVQECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLLTVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYAFLRDSAGEPLYMLFRAIKHQVDKGPVDAVTGKAKYTLNDNRLLREDVEYKTLTLNVLVQGGGVNETQPVPSKVLDCDTITQVKEKLLDQVYKGTSFSHRPHAESLDLEWRSGVAGHLILSDEDLTSVVQGSWKRLNTLQHYKVPDGATVALVPRHTKHIHHDNHDYIAGEKTPMLEDADEGGVRLWHLVKASEEPELPKHRRGSLRERERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDEQAAQHGISDSETIHIWKTNSLPLRFWINIVKNPQFIFDIQASDHVDAVLSVIAQTFMDSCTIAEHKLGRDSPINKLLYARDIPRYKQMVERYYADIRQTISASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDTTAQKMQLGYRLQQIAAAVENKVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDI8</accession>
    <name>A0A3P9BDI8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Neuregulin 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the neuregulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDI8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007811"/>
    <dbReference type="Ensembl" id="ENSMZET00005008126.1">
        <property type="protein sequence ID" value="ENSMZEP00005007811.1"/>
        <property type="gene ID" value="ENSMZEG00005005944.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158778"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Neuregulin 2a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="pro-neuregulin-2, membrane-bound isoform"/>
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    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040180">
        <property type="entry name" value="Neuregulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002154">
        <property type="entry name" value="Neuregulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11100">
        <property type="entry name" value="HEREGULIN-NEUREGULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11100:SF20">
        <property type="entry name" value="PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02158">
        <property type="entry name" value="Neuregulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="309"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="446"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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            <dbReference type="ARBA" id="ARBA00023030"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSMZEP00005007811.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="610" mass="67830" checksum="29C4EC2E2C032BD2" modified="2019-02-13" version="1">MNAHSKKHTHYGKKADSDNYIYRLIECLPFISIMQSFLCPSVCWSLVSLWPASAPKLRMISSQSLMEGKKLYLKCEASGNPSPSFRWYKDGHELQKGRDLKIKTNKKNSKVQISRVRVEDSGNYTCVAENSVGQENATSIISVQILTTTTLSPGVSHARHCNDSEKSYCVNGGDCYFIHGINQLSCKCPNDYTGDRCQNSVMANFYKAEELYQRRVLTITGICVALLVVGIVCVVAYCKTKKQRKKMQSHLHQNQNQCVEQPNRMLANGPNHPGPGPEEIPMVDYISKSVPTTECVISHGAEGAGNYAGSRMSTRSHHSTTASHASRHEEHTWSMERTESMNSDCQSGGLSSSVGTSKCSSPACMARRAAHWGCTDASGPGMQYGDSYDSLRDSPHSDRYVSALTTPARLSPVEFHYPPLPPQVPTFQITSPNTSHALSLPPAAAAYHRDDDQPLLYRQPRRPRRPYLTESTGSLPSSPYRLPDDEAYETTQEYASSREPIRSRRRPRRNRLNGHISQRSAGLRDYSSQSFSQSEEEEEDEEEEDGHGESTPFLSMQNMNMDPPLNVPGFRSSSGADTRTHRGLSRPGTRSNGQSRGSQSQRSKADNMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDL7</accession>
    <name>A0A3P9BDL7_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">Small integral membrane protein 15</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547267.1">
        <property type="nucleotide sequence ID" value="XM_004547210.1"/>
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        <property type="component" value="LG12"/>
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    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Smim15"/>
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    <dbReference type="PANTHER" id="PTHR28644">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 15"/>
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        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 15"/>
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        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
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            <begin position="54"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
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                <person name="Nishihara H."/>
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                <person name="Penman D.J."/>
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                <person name="Rakotomanga M."/>
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                <person name="Ribeiro F.J."/>
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                <person name="Sharpe T."/>
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                <person name="Tan F.J."/>
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                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="PubMed" id="25186727"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <sequence length="419" mass="48731" checksum="E312A05193C9AEED" modified="2019-02-13" version="1">MKVAKVIPIYKTGERHHFTNYRPVSILSQFSKILEKLFIKRFDSFVEKYELMTDSQYGFRNNRSTALALIDLMEKITECMDNKRYALGVFLDLKKAFDTVNHEILLKKLEKYGFRGVVLEWLKSYVGNRQQYVQINEYKSNLMDIACGVPQGSVLGPKMFIMYLNDICRVSEILKFVIFADDTNILCAGGELPQVLEMITQELTILKKWFDINKLSLNLDKTKFMLFGNQKKNIEVEICVDNVYLERVNEIKFLGVIIDHKLCWKPHITYVRGKLARGIAVLGKAKHMLDQKALHILYCALLLPYMSYCVEVWGNTYKSNTQTITIIQKRAIRLINNVGYRDHTNALFVKMQAIKFQDLVKLKTAQIMYKVRNKLLPKEICKLFIEREGGYNLRGRWNLKIQSARTTLRTMSISIAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFR5</accession>
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        <recommendedName>
            <fullName evidence="16">Voltage-dependent T-type calcium channel subunit alpha</fullName>
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    </protein>
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        <name type="common">zebra mbuna</name>
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    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="16">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.</text>
    </comment>
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            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
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    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
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    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
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    <dbReference type="PRINTS" id="PR01629">
        <property type="entry name" value="TVDCCALPHA1"/>
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    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3 16" id="KW-0109">Calcium transport</keyword>
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    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0851">Voltage-gated channel</keyword>
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        <location>
            <begin position="1"/>
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            <begin position="112"/>
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            <begin position="252"/>
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            <begin position="280"/>
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            <begin position="691"/>
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            <begin position="721"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="2343"/>
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            <begin position="1806"/>
            <end position="1840"/>
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            <begin position="390"/>
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            <begin position="1109"/>
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            <position position="265"/>
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        <ligand>
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    </evidence>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR602077-1"/>
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            <dbReference type="RuleBase" id="RU003808"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
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    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008755.1"/>
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    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="2455" mass="272400" checksum="C423ECC58907CB9B" modified="2019-02-13" version="1">MLVILLNCVTLGMFHPCEDINCDSERCKILQDFDDFIFAFFAIEMVIKMVALGIFGKKCYLGDTWNRLDFFIVLAGMLEYSLNLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWSGLLRNRCFVEDNFSFPLSLELGKYYHTENDDENPFICSQPRDNGMRDCSSIPKLYEEGGLECTLDIDSYNSTDNTTCVNWNQYYTNCSAGLINPFKGAINFDNICYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIIGSFFMINLCLVVIATQFSETKQRESQLMKEQRVRFMSNASTLASLSEPGSCYDELLKYLVHIIRKGAKQVAHICRLLARRAGLHIAASPPATDIQRSHSQRRRRKTSRQGSVSVHHIMHHHHQHHHHYHLGNGSVRGGGSTRCLDSREAEGGAHNNNGGTLIANTGSGHLAVALPSSVTAATSDMNLAILSSPAADSSSVCSIFNTNSGFAPGFFSLAPAPKSRAIKRNSVPFAAPGPKNYPTLQARALAESRRGSIAASTLTNINLNIPPMPQDRRPSSLVDPLSPTAQLSCQLSARDLSTTSSAMDTAALTLDPESCPYCAKALANESEGGTEGNETPGDSDSDGVYEFTQDLHHRDRRDSRQPKKKHQRLGKTAAKVVHFWRLVCDTFRKIVDSKYFGRGIMIAILINTLSMGIEYHEQPEELTNALEISNIVFTSLFSLEMLLKVLVYGPFGYIKNPYNIFDGIIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFMPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCRFGSERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSPVAALYFIALMTFGNYVLFNLLVAILVEGFQAEEVAKREDLHAQLSLIQLPVVSGGDASKSCSEIDSFARSMEDVNGSKKDLSASAVPANGHVDLKSNLTPPLITHTAATPMPVPKLPVGGESNPGYETRRGSSSSVDPACYEKSPTSVRSSSPYAPWSSGSGRTSRRSSWNSLGRAPSYKRQKRQSGERRSLLSGEGGSSSEDGEGGGEGGGGLMEEDDASLARTDSMSQSQRGPRHRRMESVETRSSMDLPPDALLQVPYRYRSASMHSSRPPSLSHLRPPEHNDCNGKGSPSVLGPTHVSLEENTEDENAEEEVNLGRFARLFRWLEKKQPAWCKQRDTWSLYLFPSESRFRILCNKIITHKMFDHIVLVIIFLNCITIAMERPRIDSKSAERVFLTVSNYIFTAIFVTEMTVKIVSMGFFFGDKAYLRSSWNVLDGMLVMISVIDILVSLISQSETKILGMLRVLRLLRTLRPLRVISRAPGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFICQGEDVRNITNKSDCLQASYKWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNYNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRRHQEAEEAKRREEKRLKRMEKKRRKAQSKPYYSDYSPTRLLIHKMCTSHYLDLFITIVIGLNVITMSMEHYQQPKELDEALKICNYIFTLIFVLESVFKLVAFGFRRFFKDKWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLICDELHPCEGLGRYATFKNFGMAFLLLFRVSTGDNWNGIMKDTLRDCAQDTGTCYNTVVSPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKEEAELEAEMMELEMEAGDIAARSPQLNPLTLGMDRSSSGGSPWRSPRGVDTEQERDGPMDSPTADITRDSVGIRAESPSCTEPQLEFVQRRALFDSVSLVIQGSMEGEMSLMDNLSGSICHYYALPPKPSKHSTDKKIPLAEMDALSLASENSWSLALTDDSTPDDFNPLFLTTLECNAEQLGSGALRDDNLLSVRKPAVGRTHSLPNDSYMFLSPQPVGQTSPTAAHPQGPQHILGTHRAQSGSSGSVRSQPAEFSQQLTVPTDLFRPISPHSHSDSESIPRNPPSRRTHTFSRTLRRQVAVSTDSQEALCTNVGESSEGLVNVASLGLPPSPIPSISSTSPSPYHHHQHPTPQQPALCLVPATPGASPKPSRPSTVHTQHHDQHCLASYSPCPSPPPPIPARPPQQEVSEDREVSLINQVVLAGSDDITAEDSSSSGGNEGYGSYAGCQESRSPCLRQLKRFHSADTQGRNALLPRPRPYSWLDDPRRHSVEVCSPVDSSPQCSTNSTSSGFVSRADSLQIQSHIPAQTSPRRKKKMSPPCISVDPPEGLEPQSGLYPCLGGLGGMGLTGIGMPPPLPNRDTYLRRRAPSSDSKDSFDLAVGEGSGQDGGSPNPNTNSKLLTLPSFSFEKTSSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGK2</accession>
    <name>A0A3P9BGK2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGK2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009040"/>
    <dbReference type="Ensembl" id="ENSMZET00005009389.1">
        <property type="protein sequence ID" value="ENSMZEP00005009040.1"/>
        <property type="gene ID" value="ENSMZEG00005006810.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160421"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000054">
        <property type="entry name" value="Calpain 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000001">
        <property type="entry name" value="Calpain-1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF302">
        <property type="entry name" value="CALPAIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="11">
        <location>
            <begin position="47"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="634" mass="71858" checksum="50D82F3523B6AB9D" modified="2019-02-13" version="1">MPLPGACLNIMEARHKQKGYGSICNPERFCNQDFKNLKQYCLIKGVRYLDDMFPPDGKSIGQGILKPSDLAHVKWLRPAQIAPDAEFVVDGVSRFDFGQGVLGNCWFLASIGALTFQNHIFEQVVPLDQKIKENYCGIFHFRFWRFGRWVDVVIDDKLPTINGRLIFVHSKDPNEFWPALLEKAYAKVCGSYTDMTSGTPSEAMMDFTGGVHMCVQLSDASSDVWGLICRAGKSNTLMGCGTPQGETSANTVLPNGLVQGHAYTVTGVKELISQGKLVKLIRLWNPWGKGEWVGDWSDRSPMWDIVSSQDRQMCLSVADDGEFWMAFEDFCKFYTDLDICGLKPDFIDGKSSAQWKTSVYEGRWVAGTTAGGCINNRDTFWTNPQYRIKVVGENSETNGEKNILVSLMQKPDKRNRRLVQNLHIGFAVYLYKTQSGKFPAMFFNTHLPVARSDKYMNAREVIEFLMLKPGEYLIVPSTFKPNETASFILTIHSREETCCYKPNQLMFQYEEVDAEQLQRLLNENILKGLAFKKSVKLNLNLLAGRRVNIILTRLTLTALVYVCMYIYLSKLLLKSDCVCSSGMKVSDDMLSLMALRYGASSGHMALECFISLMIRLDCMKTENKSHWMYVSMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGK9</accession>
    <name>A0A3P9BGK9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding motif, single stranded interacting protein 2a</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004545008.1">
        <property type="nucleotide sequence ID" value="XM_004544951.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGK9"/>
    <dbReference type="Ensembl" id="ENSMZET00005009376.1">
        <property type="protein sequence ID" value="ENSMZEP00005009027.1"/>
        <property type="gene ID" value="ENSMZEG00005006839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467052"/>
    <dbReference type="KEGG" id="mze:101467052"/>
    <dbReference type="GeneTree" id="ENSGT00940000155250"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12471">
        <property type="entry name" value="RRM1_MSSP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12474">
        <property type="entry name" value="RRM2_MSSP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000012">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000014">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="58"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="137"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="399" mass="43528" checksum="9004AA7B3821FC7C" modified="2019-02-13" version="1">MLLSVSPRAGINPYNGYNSRNSKKQTYVSSGHQMAPPSPNTNSSSNSSGGGGEQLSKTNLYIRGLHPGTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVTTLKSTGVQAQMAKQQEQDPTNLYISNLPVSMDEQELESMLKSFGQVISTRILRDANGTSRGVGFARMESTEKCEAIIQHFNGKFIKTPPGIPVPTEPLLCKFADGGQKKRQNQSKYLQNGRPWARDGDTGGMTLAYDPTALQNGFYSSPYSLAPNRMIAQTSLSPYMHSPVSSYQVHNPSWMHHQSYLMQPAGTVITPTMEHAMSIQPTSMMGPLTQQLSHLSLGSTGTYIPANTTMQGTYIPQYTPVPPSSVPVEENGGQQQQVAMETPTEHTNYSYQHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BH83</accession>
    <name>A0A3P9BH83_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BH83"/>
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    <dbReference type="Ensembl" id="ENSMZET00005009588.1">
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        <property type="gene ID" value="ENSMZEG00005007004.1"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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        <property type="entry name" value="RNaseH_sf"/>
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        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="65"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="263" mass="29801" checksum="8BC30DEF826F5976" modified="2019-02-13" version="1">MPLATSLAIFQSCNITGVPKSTRCAILRDMAKVRKAERRPPLNKTHKLKRQDWAKKYLKTGFSKVLWTDEMRVSLDGPDGWARGWIGKGQRAPVRLRRQQGGGGVLVWAGIIRDELVGPFRVEDGVKLNSQSYCQFLEDTFFKQWYRKKSASFKKNMIFMQDNAPSHASTYSTAWLARKGIKEEKLMTWPPCSPDLNPIENLWSIIKCEIYKEGKQCTSLNSVWEAVVAAARNVDGEQIKTLTESMDGRLLSVLAKKGGYIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BI73</accession>
    <name>A0A3P9BI73_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BI73"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009597"/>
    <dbReference type="Ensembl" id="ENSMZET00005009956.1">
        <property type="protein sequence ID" value="ENSMZEP00005009597.1"/>
        <property type="gene ID" value="ENSMZEG00005007257.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016067"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="201" mass="20842" checksum="64B617D60CC1C28A" modified="2019-02-13" version="1">MAASTRAANAAASNPQGPASVGPSVDSPTLQYSMILEHLIGDKRPVKGLNPAVMGGLPVPPKSDEQKMIERGMESCAFKSLLACVGGFVLGGAFGVFTAGIDTNVGIDPKDPLRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECIIESHRGKSDWKNAVYSGCVTGGAIGFRAGLKAGVLGCGGFAAFSAAIEYYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIR8</accession>
    <name>A0A3P9BIR8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">trypsin</fullName>
            <ecNumber evidence="5">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIR8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009788"/>
    <dbReference type="Ensembl" id="ENSMZET00005010147.1">
        <property type="protein sequence ID" value="ENSMZEP00005009788.1"/>
        <property type="gene ID" value="ENSMZEG00005007409.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144271"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000005">
        <property type="entry name" value="Serine protease 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF87">
        <property type="entry name" value="ARGININE ESTERASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="196" mass="21476" checksum="B935F0A0A870B836" modified="2019-02-13" version="1">ALRNSSGCRGGSMRYMVSVQNNGGHVCGGFLITNNFVVTAAHCFNDFPTHVVLGNHNLKNGQIVEIKNKFVYSSYNTPEKGDDIMLLQLATTNDLHDEIQLPHAEIDLTENEVCQVAGWGKTMNGGKTVGELRVVDVSVINPQVCKNQWPQLPANVICAGGYGTSKGFCQVCILSNVSRFLFDKCTVLNTYYKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BKE9</accession>
    <name>A0A3P9BKE9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="9">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_004556854.1">
        <property type="nucleotide sequence ID" value="XM_004556797.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BKE9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010407"/>
    <dbReference type="Ensembl" id="ENSMZET00005010778.1">
        <property type="protein sequence ID" value="ENSMZEP00005010407.1"/>
        <property type="gene ID" value="ENSMZEG00005007834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472257"/>
    <dbReference type="KEGG" id="mze:101472257"/>
    <dbReference type="CTD" id="794083"/>
    <dbReference type="GeneTree" id="ENSGT01030000234646"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000001">
        <property type="entry name" value="[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF15">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="242"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="409" mass="46511" checksum="E10F780A445BE9F5" modified="2019-02-13" version="1">MKFVRFIMKNAAVASAPQHIEHFSKFSPSPLSMKQFLDFGSINACEKTSFAFLRQELPVRLSNIMKEINLLPDKLLTTPSVKMVQGWYVQSLMELLEFLDKNPDDHKVLGEFVDTLVTIRNRHNDVVPTMAQGVIEYKEAFPQDVATNQNIQYFLDRFYMSRISIRMLINQHTLIFDGTTNPVHPNTIGSIDPHCKVGDVVQDAFGSAKMLCDQYYLCAPDVILQEMNLKKTNHPVTIVYVPSHLYHMLFELFKNAMRATIETHESSRNLPPIKVMVSLGDEDLTIKVSDKGGGVPFRRIENLFSYMYSTAPAPQIGDQKRPPLAGFGYGLPISRLYAKYFQGDLQLYSMEGYGTDAVIYLKALSTDSIERLPVYNKTALKNYKMSQEADDWCVPSKEPLDLSSYKVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLM5</accession>
    <name>A0A3P9BLM5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Complex I-49kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase 49 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme. Interacts with NDUFAF3. Interacts with NDUFAF7. Interacts with CERS2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567153.1">
        <property type="nucleotide sequence ID" value="XM_004567096.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLM5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010839"/>
    <dbReference type="Ensembl" id="ENSMZET00005011216.1">
        <property type="protein sequence ID" value="ENSMZEP00005010839.1"/>
        <property type="gene ID" value="ENSMZEG00005008133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467150"/>
    <dbReference type="KEGG" id="mze:101467150"/>
    <dbReference type="CTD" id="4720"/>
    <dbReference type="GeneTree" id="ENSGT00390000009529"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="13">
        <location>
            <begin position="196"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="466" mass="53002" checksum="F45D764CD0770B3C" modified="2019-02-13" version="1">MAATMLRSLSKLGRPSTKLLLGHNVLSPGCALLQNRQKQWQPDVEWTEQFAGAVMYPTAVNEKWTPPPWNDKDPPAEKEVSNLTINFGPQHPAAHGVLRLVLELSGESVKKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIQAPPRAQWIRVLYGELTRILNHIMAITTHALDIGAMTPFFWMFEEREKMFEFYERVSGARMHAAYVRPGGVHQDLPLGLMDDIYEWCKNFSIRIDEVEEMLTNNRIWKNRTVDIGVVSAEEALNYGFSGVMLRGSGIKWDLRKSQPYDKYDEVEFDVPIGSNGDCYDRYLCRVEEMRQSLRIMHQAMNKMPEGEIKVDDAKVAPPKRSEMKMSMESLIHHFKLYTEGYQVPPGATYTAVEAPKGEFGVYMVSDGSSRPYRCKIKAPGFAHLAGLDKMAKGHMLADVVAIIGTQDIVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BN29</accession>
    <name>A0A3P9BN29_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G protein-coupled receptor 84</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004544963.1">
        <property type="nucleotide sequence ID" value="XM_004544906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BN29"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011021"/>
    <dbReference type="Ensembl" id="ENSMZET00005011402.1">
        <property type="protein sequence ID" value="ENSMZEP00005011021.1"/>
        <property type="gene ID" value="ENSMZEG00005008264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480161"/>
    <dbReference type="KEGG" id="mze:101480161"/>
    <dbReference type="GeneTree" id="ENSGT00940000161671"/>
    <dbReference type="OrthoDB" id="6117944at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001604">
        <property type="term" value="F:urotensin II receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF59">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="40"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="407" mass="45790" checksum="B22157864A5317BD" modified="2019-02-13" version="1">MMNQTNHTEDVFSCYSPSVEIYRYFAVLWGCAVTITGTVGNLMTVLAFVLDPRLRTRFNVLIVNLAVADLLYCTILQPISVDSYLHLRWHSGHLWCRIFGLLLFLSNSVSIITLCLVAVGRYLLVAKRAVFDRVFSNHGLTLLIIFAWALGLVSFGPLWSVYVFVPQVCTCSFHRTEGRPYTTILLFFYFFIGLGFVGAFYLLIYKKVQAASQALLRYRLSRRSSKTKPANSVQGTDDSGVESGIKTCTSDLSSHEISQNMDVKNQNVTCEKSSFSTTSNDTALNSSAAQKPSTDIIEKPPTTTPAKTAHSSHSATSGDDSEFKRVTRMCFTVFLCFVFCFVPFLLLNIADKQNRAPQVLHMFCANLTWLNSCINPVLYAIMNRQFRQAYHVVLSKMTAPFTRLYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNJ4</accession>
    <name>A0A3P9BNJ4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Transferrin receptor protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="15">Stearoylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNJ4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011497"/>
    <dbReference type="Ensembl" id="ENSMZET00005011897.1">
        <property type="protein sequence ID" value="ENSMZEP00005011497.1"/>
        <property type="gene ID" value="ENSMZEG00005008562.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234598"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004998">
        <property type="term" value="F:transferrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033572">
        <property type="term" value="P:transferrin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09848">
        <property type="entry name" value="M28_TfR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02128">
        <property type="entry name" value="PA_TfR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000065">
        <property type="entry name" value="Transferrin receptor 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000002">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000010">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037324">
        <property type="entry name" value="TfR1/2_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF26">
        <property type="entry name" value="TRANSFERRIN RECEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13 15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="16">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="377"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="17">
        <location>
            <begin position="668"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="761" mass="83869" checksum="66F35877926ADD26" modified="2019-02-13" version="1">MDQARSAMSQIFNNEPHSYTRFNLPDNMEGDTSQVEMIQSSDMNEEVGENGDEGHLSHKSNRQPHVAQNFECTTKSLCFMAATIVFTFVIGYLTGYLVHKNKDLNCSCAPSEDDITHKTGAVPFMDWDDVRKLLGDKLNTSNLEIALSNHRAGSPGDEDLGNKVIKKFKEYGMKTWTDEYFVKVQDPPASGYNRIVFKNGSEERPTGFLSYSASGTARGAVLYAHYGQEDDFKQLKNMNINMNNRVMLVRAGRISFAEKVANAAKVNASAVLIYPDPADYPIGNDTSLFGHVHMGSGDPYTPGFPSFNHTQFPPVQSSGLPHILAQTITTGMGTKILRQLGGRTQPNGWEGINRLGDESDVITVEVNNVLTEKRINNVFGVIKGFVDADRYVVIGAQRDAWGPGFAASSVGTSVLVELARSISDMVENDGFKPRRSMVFASWSAGEYGSVGATEWLEGYLSSLSMKAVAYINLDGIVTGQNGFKVAASPLLHSLVQNALKEVNYDKDKSLLSQFGKNNWESAILEPLRMDSAAYPFLAFSGIPSVAFRFHSGSSDYPHFGTNLDTRENLNSVTASQVPQLAVRAGQFAGHIALRLVHDHLLQMDLKKYNQLIRSHVVQINGKVKAVQRLQPQLLPKTLTGQWLVMASGSYNRVSNILTADIQNSDLENVEMCRMINDRIMTVERNFLSPYVSPIDSPFRHILLGSGPHTLKPLSSHLDALKSASPEANAELFRNKLAQATWTIQACANSLAGDIWSLDNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BP19</accession>
    <name>A0A3P9BP19_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004558991.1">
        <property type="nucleotide sequence ID" value="XM_004558934.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BP19"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011664"/>
    <dbReference type="Ensembl" id="ENSMZET00005012070.1">
        <property type="protein sequence ID" value="ENSMZEP00005011664.1"/>
        <property type="gene ID" value="ENSMZEG00005008750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482340"/>
    <dbReference type="KEGG" id="mze:101482340"/>
    <dbReference type="CTD" id="55661"/>
    <dbReference type="GeneTree" id="ENSGT00550000074997"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-dependent RNA helicase DRS1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF22">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="216"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="420"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="677"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00012552"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00047984"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011664.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="756" mass="85653" checksum="EC94E0F1AF65A238" modified="2019-02-13" version="1">MLEQLGLIGTIRDEDPIPDEAETESEQEEEPIVLKKKKKSRGSRDFNCDFEFGERDGPSHDDDWAMADVMKQLKKKRTLTTLDQKIEKIRRKRKAEEKSSQSDAAEASSENHQEEEDVKPPAGETDASDEDEDKDEDEEFGSSDEEILTKSDTLRDKERRGKKRKVAEEAAESFYEDASQYDDQLTFDDMNLSRPILKAITALGFKQPTPIQKACVPVGLLGKDLCACAATGTGKTAAFMLPVLERLVYKPRTSQVTRVLVLVPTRELGIQVHSVARQLAQFTSITTCLAVGGLDLKSQEAALRAGPDILIATPGRLIDHLHNTPSFELTHIEILILDEADRMLDEYFEEQMKEIIRLCSYNRQTMLFSATMTEEVKDLAAVSLKQPVRIFVNSNTDVAPFLRQEFVRIRPHREGDREAVVAALLTRTFQDHVMLFTQTRKQAHRLHILLGLMGLKVGELHGELSQNQRLENLRRFKDEQIDILVATDVAARGLDIDGVKTVINFTMPGTVKHYVHRVGRTARAGRSGRSVSLVGESERKMLKEVVKSAKSTVKARVLPPEVILKFRDLIAKLEKDVEAVMKLEREERELAASEAKLSVAQRRLTDSASSDQSQRVWFQTQQERKQSRMSKALQEFDLAVRGKKKREKFLKDGRKKELTSEERAQFEILKAQMFAERAAKRERRPKRARAMPEDEAPTKAANQKAGKGGKKSVFDKELTNTSSKALKQYRAGPSFADRKRLGVDRKRPGSSRFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BPF8</accession>
    <name>A0A3P9BPF8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Forkhead box P1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
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            <begin position="465"/>
            <end position="538"/>
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            <begin position="1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQ10</accession>
    <name>A0A3P9BQ10_9CICH</name>
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        <submittedName>
            <fullName evidence="16">Interleukin 6 signal transducer</fullName>
        </submittedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
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        <property type="protein sequence ID" value="ENSMZEP00005012028.1"/>
        <property type="gene ID" value="ENSMZEG00005009041.1"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="Interleukin-6 receptor subunit beta"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="IgC2-like_lig-bd"/>
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    <dbReference type="InterPro" id="IPR052672">
        <property type="entry name" value="Type1_Cytokine_Rcpt_Type2"/>
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    <dbReference type="PANTHER" id="PTHR48423">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423:SF1">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06328">
        <property type="entry name" value="Lep_receptor_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01353">
        <property type="entry name" value="HEMATOPO_REC_L_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018039459" evidence="14">
        <location>
            <begin position="21"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="229"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="446"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="536"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="734"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="863"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="894" mass="100443" checksum="C831F533DE87B32E" modified="2019-02-13" version="1">MVSAAVLHLWVLAWLASVLAAEDDYHLVIAPQSPVVQIGSNLTAICMINNTTEVTADDLYWKLSEIIPKEHYIKINSSALNVTVTIRSEKSEWLFCSCKTESHYVVLNRGKFTHGIWLRKGYRPEKPKNLSCIAVQESDTISSNIKCQWEAVGHQTEAVPTNYTLFIRQTGDKIYTASILGPVNKTTVDLNLFPHHMELEIWVVAQNELGKEESEHLIKLANCFVKTKPPSVAVISEAVFPTSLVMSWNSSIDKSYLETIYEIRFCPLGSQKWFYVPLADTSRYIQSFRLQNLQPDTVYVTQVRCKYNNNNKHCGYWSDWSSNVTERTPEDLPKSKPDVWIITSEEGLNKRQIEFICKDPEFSNGRIRRFNITIEKQKDSIRNGTWEIIPVNRSLTDGSSSKKQITPLKTITLDDEESVTVYVTAINSVGASPQAKLIISRKTREPPAVEKTEVQSHNGQLFLSWKPPNRTVSEYVVEWVSDGERNWQRENGKTNYTAIKGDLKQFVQYRISVYPIYGKLVGKPVLERAYFEQGVPSQGPIVNLSGDPGCYTAKLEWDEIPLIKRRGFITNYTIYYRSGTETRGITVPANTTSYTLTSLSRNTKYDIWIKASTIRGSVNGSNHSFTTLKYAPGEIEGIVVGVSLGFLFVVLMTMLLCFCKKDVIKDNFWPQIPNPGDSTIGNWSPDYPLKAEAPRENCLSGISVLNVDVCDAKCVFEEDKASLPLKKDKYLSEEHSSGIGGSSCMSSPRQSVSDSDEGGDMADTTASTIQYSSVVASSGYKGQNPSSLPQQSIFSRSESTQPLLDCEENHDTMVQEGSRQCFLRQPCFTHNAGNENATDSNDFNPLEMEQQEVLDFCPLEEDTEHTAPADCQSDDWIPAPVSSYMPQLGGYRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRI7</accession>
    <name>A0A3P9BRI7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRB2-associated binding protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAB family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRI7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012560"/>
    <dbReference type="Ensembl" id="ENSMZET00005013004.1">
        <property type="protein sequence ID" value="ENSMZEP00005012560.1"/>
        <property type="gene ID" value="ENSMZEG00005009435.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156801"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090504">
        <property type="term" value="P:epiboly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01266">
        <property type="entry name" value="PH_Gab1_Gab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000166">
        <property type="entry name" value="GRB2-associated-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046355">
        <property type="entry name" value="Gab1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960:SF5">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="777" mass="85194" checksum="9FB1F8BACFF161F7" modified="2019-02-13" version="1">MSGGEVVCSGWLRKSPPEKKLRRYAWKKRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRVIDLNLCEQVDAGLTFSKKDLENSYIFDIKTFDRIFYLVADTEDEMNKWVRHICDICGFNPTDDDAAKAAHQSAMGLVVENAPHPGPGVFTNVPAPYQPVSVRHLDSQSSSEEPQDYLWLANCESKKPEPSSSVEHHSLLERDQEYLLLEECESKTVPPQASLAHAECSKSTSSETDLNDNLPSHRTPTSSTSSAKHTSHNGFFPPHQTPVSAPSIYDSPPSRGASLSTDSGFYHLPRSYSQDTVLLPKSASSPPAHPDGADASDLYVFNTPTRKPSVETQMRNISISYDIPPTPGANSTYQVPRTVSNTGVGGSESGGDVVPPPRPPKPSLSSSSGLPPPPAERSPTDTYSVPRSASETDGNYCVPTSAGSKALRSNTIGTVDCSRLRKDFGSQDCYDIPRSFPSDKSCSFDFNESFNTYFKSKGMMPVGSHSTEEVDQNYVPMSANSPSHHHSGSLPEPMHETNYVPMTPGTMEFSSLGKQVPPPAHMGFRSSPKTPPRRPLLSECQPPPVDRNLKPDRKGHSPKIIRAGLERTDSQTVGEFPSRRRKVKPAPLEIKPVPEWDEPSTPVRSPVTRSFARDPSRFPMPTRPPSVHSTASSTDSEDSTEPNYVAMNPNMSTDEAITKLAPPMNADGGSSPVVKPKGDKQVEYLDLDLDSGKSTPPRKMKSNGTGITASDERVDYVVVDQQRTQALKSTREAWSDGRQLTETDTPSKGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRW7</accession>
    <name>A0A3P9BRW7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRW7"/>
    <dbReference type="Ensembl" id="ENSMZET00005013119.1">
        <property type="protein sequence ID" value="ENSMZEP00005012675.1"/>
        <property type="gene ID" value="ENSMZEG00005009331.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163324"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000096">
        <property type="entry name" value="Odorant receptor 131-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052921">
        <property type="entry name" value="GPCR1_Superfamily_Member"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF886">
        <property type="entry name" value="GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="272" mass="31371" checksum="D0982940D2515B53" modified="2019-02-13" version="1">MTLLNNVFLQRPNDRMIIVQILVIIFLCINMFILLFVSDILVILTYYQFTIQVWLCIISTIFVLMYTFVTPVTLTAMTLECYVAICMPLRHGQLCSTRSTMYCILIIHVLSSGPCIIILSMFFASASLKFYKQSIICSVEAFTLYRWQDHVRSAVYQCYFLIMGITIAYSYVQIMKVAKAASGDKKKLTHKGLKTVILHAFQLLLCLIQLWCPFIETAVLQIDLRLFIDVRYSNYIMFSIAPRCLSPLIYGLRDEHFFLVLKSLMPTSSCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BS09</accession>
    <name>A0A3P9BS09_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Opioid growth factor receptor (OGFr) conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BS09"/>
    <dbReference type="Ensembl" id="ENSMZET00005013156.1">
        <property type="protein sequence ID" value="ENSMZEP00005012712.1"/>
        <property type="gene ID" value="ENSMZEG00005009538.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018730"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF1">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="100"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="342" mass="40158" checksum="A0A52492C0180EFC" modified="2019-02-13" version="1">MRTENAVDEGKKLTGPEEEEEEFDSTEYRVHTTDEFYCDYDSTWETDPNEETPPSRIRQTTNYVSKPVPVTSTLIFHVCSQIIYCRHKRSHLSQAHRPKVITEFHEQWYGDYESLEHVQTYNQWLFPLQEPGVNYEASTLTKEEITVNLLAQENLLKSYKLMLDFYGIVLCDEKTGEVRRAKHWEERFDNLNSHTHNSLRITRILKCLGNLGYRHYQAPLVHFFLEETLVNGQLPNIRDSVLSYFMFAVLDKKKCRGLIKYAYLNYEPKDEFVWCPKKIQKLWSMQPKAAKEEAADSLESQEDTVISDSEAQEEENLSADESCNNAEYESREGEETFSHNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSC1</accession>
    <name>A0A3P9BSC1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549412.1">
        <property type="nucleotide sequence ID" value="XM_004549355.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSC1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012822"/>
    <dbReference type="Ensembl" id="ENSMZET00005013267.1">
        <property type="protein sequence ID" value="ENSMZEP00005012822.1"/>
        <property type="gene ID" value="ENSMZEG00005009608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475833"/>
    <dbReference type="KEGG" id="mze:101475833"/>
    <dbReference type="CTD" id="23158"/>
    <dbReference type="GeneTree" id="ENSGT00940000157878"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13351">
        <property type="entry name" value="PH-GRAM1_TCB1D9_TCB1D9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13354">
        <property type="entry name" value="PH-GRAM2_TCB1D9_TCB1D9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000013">
        <property type="entry name" value="Putative TBC1 domain family member 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000008">
        <property type="entry name" value="TBC1 domain family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000119">
        <property type="entry name" value="TBC1 domain family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000041">
        <property type="entry name" value="TBC1 domain family member 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000016">
        <property type="entry name" value="TBC1 domain family, member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036014">
        <property type="entry name" value="TCB1D9/TCB1D9B_PH-GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036017">
        <property type="entry name" value="TCB1D9/TCB1D9B_PH-GRAM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666:SF3">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="510"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="881"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1188"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1280" mass="145879" checksum="76E63247D27FE19B" modified="2019-02-13" version="1">MWVTPEDVLLAGALWITERANPYFILQKRKGHGDGGGGLAGLLVGTLDVVLDSSARMAPYRILYQTPDSLVYWIIAHGTSRKEITEHWEWLEHNLLQTLSIFENENDITTFVKGKVQGIIAEYNKNHDVKEDDDTDKFKEASAKFRKLFGMPEEEKLVNYYSCSYWKGKVPRQGWLYLSINHLCFYSYLLGKEVKMVVRWADITQLEKSATLLLPDVIKVSTRTNEHLFSVFLNINETFKLAEQLANIAMRQLLDNKGFEQDRSLPKLKKKSPKKVSALKRDLDARAKSERYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEESLCSLIIPLREVTIVEKADSSSVLPSPLSISTKNRMTFLFANLKDRDFLVQRLSDFLQQTTSKTYLEKELTSSLNSSDDEVYSQHGSLLSSSPHHSLGSEGERKFNLNDSSVPTATQALMTMYRRNSPEEFNPKLAKEFLKEQAWKNHFTEYGQGVCMYRTEKTKELVLKGIPESMRGELWLLFSGAINEMTTHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELAREYIPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYDGIKVIFQLALSVLHANIHQLLGCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLTDNGEPHPEVDIFKLVRSSYEKFGSIRADVIEQMRFKQRLRVIQTIEDTTKRNVVRTIVTETDFSIDELEELYVLFKAEHLTSCYWGGSSNPTERHDPSLPYLEQYRIDVEQFKGLFNLLFPWANGAHSEPLAVRFFRLLDQNADALINFREFITGLGVLCHGDLTEKLKLLYKMHVLPEMTHEQEEPDSAFEATQYFFEDITPETSVGHDSKCRNEKDDGFVRVTFKTEKVKKLNTPDYRHYLKLWNQEMRPKRENTKDLPKLNQSQFIELCKTLYSMFSEDVAEQELYHATATVTSLLLEMGEVGKLFSSSFRKDHNQEGNSEPSVCMRDVLDPKGTQEVQELGDIFVPAGLENKPSPCEEGKGDEDSEQLPPMQDIKLEDSSPKDTGTSSAMLISDDETKDDTSMSSYSVLSAGSHEMDEKLQCEDIADDTVLVRSDGGSNGERSNRPLGGGPHDRGLPHSTSIDKDWAITFEQFLASVLTEQALVRYFEKPVDVAARITNAKNAKKVGRPLLSTSDYEISLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSV9</accession>
    <name>A0A3P9BSV9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heterogeneous nuclear ribonucleoprotein H1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_014267599.1">
        <property type="nucleotide sequence ID" value="XM_014412113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSV9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013035"/>
    <dbReference type="Ensembl" id="ENSMZET00005013484.1">
        <property type="protein sequence ID" value="ENSMZEP00005013035.1"/>
        <property type="gene ID" value="ENSMZEG00005009791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470951"/>
    <dbReference type="CTD" id="3187"/>
    <dbReference type="GeneTree" id="ENSGT00940000165206"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12729">
        <property type="entry name" value="RRM1_hnRNPH_hnRNPH2_hnRNPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12731">
        <property type="entry name" value="RRM2_hnRNPH_hnRNPH2_hnRNPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12734">
        <property type="entry name" value="RRM3_hnRNPH_hnRNPH2_hnRNPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000071">
        <property type="entry name" value="heterogeneous nuclear ribonucleoprotein H isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000075">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein H1 (H)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000031">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein h3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012996">
        <property type="entry name" value="Znf_CHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08080">
        <property type="entry name" value="zf-RNPHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="253"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="406" mass="44167" checksum="6270DFBAF23D141F" modified="2019-02-13" version="1">MADEGYVVRIRGLPWSCSVDEVQRFFSECKILNNGSGIHFTYTREGRPSGEAFVEFETEEDLKIAVKKDRETMGHRYVEVFKSNNVEMDWVMKHTGPNCPETAGDGLVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDIQGRSTGEAFVQFASQDIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYEPQRKPMGMQRPGPYDRPSGGRGYNMMGRGGSYDRMRRGGYGGGVSDGRYGDGGSSFQSTTGHCVHMRGLPYRATETDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEDAVAAMSKDKANMQHRYVELFLNSTAGGSNGAYSSQMMGGMGSQSSYSGGQLSSGYSGGYSSQGNMGGYSDYSNQGGMGSSYYGGGGGGSRGSMNGLGGGWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTB9</accession>
    <name>A0A3P9BTB9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-terminal asparagine amidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004538969.1">
        <property type="nucleotide sequence ID" value="XM_004538912.4"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005013208"/>
    <dbReference type="Ensembl" id="ENSMZET00005013658.1">
        <property type="protein sequence ID" value="ENSMZEP00005013208.1"/>
        <property type="gene ID" value="ENSMZEG00005009925.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101484909"/>
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    <dbReference type="GeneTree" id="ENSGT00390000016730"/>
    <dbReference type="OrthoDB" id="539995at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NTAN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498">
        <property type="entry name" value="N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N_Asn_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="307" mass="34007" checksum="A4471998805840B5" modified="2019-02-13" version="1">MPLFIQNKPLDRIRSTADLFDKNPHLQEKAKAFRSKPLVDVDPKCLLYVHQREFAATTPADKCVSVIGSDDATTCHLVVLRHTGSGAVCLGHCDGSSTWSEVPLLVKAVTSLSDACKEGRLELHLVGGFNDDSTTSHNLSLDILAAFQVQKEDIHLETCCITEMNDVVVNGTHRPVVYGIGVDVKTGDVYPASFPHKGPAEELRSARTFTGGEMVNIYDSSRGLFQIGPCTWSQNLDIAFWLSQNDDTILKYLSTSPRAEPPHFVQHMKSTIQFLLDHPNSESLFPGGQPQFYHRTETGDWERVVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTQ3</accession>
    <name>A0A3P9BTQ3_9CICH</name>
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        <submittedName>
            <fullName evidence="5">Si:ch73-389b16.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTQ3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013340"/>
    <dbReference type="Ensembl" id="ENSMZET00005013794.1">
        <property type="protein sequence ID" value="ENSMZEP00005013340.1"/>
        <property type="gene ID" value="ENSMZEG00005010027.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153190"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875:SF8">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="131" mass="15387" checksum="708DDDA6CED6C142" modified="2019-02-13" version="1">MSKCHSELTQKEREMLKIRRDSDTKAAELVKMERMLQQTKNLLDKKTESGSKSLGYQENMEDLEEKVRSSRRYRRNSLHHTQMLESQMKTVKGELVGTLDHLQELRNVLRRSQQKAEERKAAMEKLAAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWM2</accession>
    <name>A0A3P9BWM2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SEC63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
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                <person name="Aken B."/>
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                <person name="Amemiya C."/>
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                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWM2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014368"/>
    <dbReference type="Ensembl" id="ENSMZET00005014848.1">
        <property type="protein sequence ID" value="ENSMZEP00005014368.1"/>
        <property type="gene ID" value="ENSMZEG00005010822.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176296"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000388">
        <property type="term" value="P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000048">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF5">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SEC63" evidence="8">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="153" mass="17292" checksum="7052921BE56F13BF" modified="2019-02-13" version="1">MEMEDEDRSALLQLSDAQMADVARFCNRYPNIELSYEVAEKDSVKSGSPVLVQVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDPKSNSLISIKRLTLQQKAKVKLDFVAPAMGIHNYTLYFMSDAYMGCDQEYKFSIDVKEADSDGDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BX12</accession>
    <name>A0A3P9BX12_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cathepsin B</fullName>
            <ecNumber evidence="3">3.4.22.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.</text>
            <dbReference type="EC" id="3.4.22.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_024657706.1">
        <property type="nucleotide sequence ID" value="XM_024801938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BX12"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014429"/>
    <dbReference type="Ensembl" id="ENSMZET00005014909.1">
        <property type="protein sequence ID" value="ENSMZEP00005014429.1"/>
        <property type="gene ID" value="ENSMZEG00005010856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475690"/>
    <dbReference type="KEGG" id="mze:101475690"/>
    <dbReference type="CTD" id="406645"/>
    <dbReference type="GeneTree" id="ENSGT00940000158680"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060026">
        <property type="term" value="P:convergent extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090504">
        <property type="term" value="P:epiboly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031101">
        <property type="term" value="P:fin regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018713120" description="Cathepsin B" evidence="11">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="12">
        <location>
            <begin position="79"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="330" mass="36254" checksum="450B15E7C7DAD318" modified="2019-02-13" version="1">MWHAAFLLLAASLSVSLARPHLHPLSSEMVNHINKLNTTWKAGHNFHNVDYSYVRKLCGTMLKGPKLPVMVQYAGDLKLPKEFDARQQWPNCPTLKEVRDQGSCGSCWAFGAAEAISDRVCIHSNGKVNVEISSEDLLTCCDSCGMGCNGGYPSAAWDFWANEGLVSGGLYDSHIGCRPYTIAPCEHHVNGSRPPCTGEGGDTPECVRQCESGYTPSYTQDKHYGKTSYSVPSDEQQIQYEIYKNGPVEGAFTVYDDFVLYKTGVYQHVSGSAVGGHAIKILGWGEENGTPYWLCANSWNTDWGDNGYFKFLRGSDHCGIESEIVAGIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXR4</accession>
    <name>A0A3P9BXR4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Fibronectin type III and SPRY domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="11">May be involved in microtubule organization and stabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomerization is required for binding to microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
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            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004554924.1">
        <property type="nucleotide sequence ID" value="XM_004554867.4"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9BXR4"/>
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        <property type="protein sequence ID" value="ENSMZEP00005014637.1"/>
        <property type="gene ID" value="ENSMZEG00005011009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479349"/>
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        <property type="component" value="LG23"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Immunoglobulins"/>
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    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
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        <property type="entry name" value="fn3"/>
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        <property type="entry name" value="BUTYPHLNCDUF"/>
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    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
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        <location>
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            <end position="268"/>
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            <end position="331"/>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014637.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="493" mass="55473" checksum="FE9F0BC65546CBBF" modified="2019-02-13" version="1">MGDQKESLRKITHTLAMKNEEISNFICTLKQSLDNLEANSNRVQEDLESECSSLHAVLDEMKENMLTRIKQERASRTYELQSQLSACSKALESSEELLEMANQTLCSSETDGFTQAAKDIKDSVTMAPAFRLSLKAKASDNMSHLMVDFSQEREMLQGLKFLPVPATPEIQVSECQVCDNTVTVVWSLPEPDSKIDHYILEHRRTNHEGPPRIREDYPWMVVEGIREMEHTLTGLRFDTRYLTFRVRACNKAVAGEFSEPVTLETHAFTFKLDAASAHQNLKVEDLSVEWDSSGGKIQDIRKDKNRTNSPMHSPARSALMSPKRAPTARPGRDRFTAESYTVLADTVIDAGQQYWEVRFDKESKAFAVGVALRSLGRFDQLGKSSASWCIHLNNWLQQSLTAKHNNKARTLDCPIPNSIGVYINYDEGILSFYNAKTKQLMHTFKTKFQQPVIPAFMVWNGSFSVVTGLQVPSVVQSGQRKNSGTSSSNASLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYC9</accession>
    <name>A0A3P9BYC9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Atonal bHLH transcription factor 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004559701.1">
        <property type="nucleotide sequence ID" value="XM_004559644.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYC9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014975"/>
    <dbReference type="Ensembl" id="ENSMZET00005015463.1">
        <property type="protein sequence ID" value="ENSMZEP00005014975.1"/>
        <property type="gene ID" value="ENSMZEG00005011258.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479167"/>
    <dbReference type="KEGG" id="mze:101479167"/>
    <dbReference type="CTD" id="220202"/>
    <dbReference type="GeneTree" id="ENSGT00940000161556"/>
    <dbReference type="OrthoDB" id="6161578at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043473">
        <property type="term" value="P:pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036269">
        <property type="term" value="P:swimming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000025">
        <property type="entry name" value="protein atonal homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF162">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="143" mass="16622" checksum="0E414418C91E750F" modified="2019-02-13" version="1">MKARRPSCTDSGSESSELDSKSPEKYETATRRRMAANARERKRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIVALNRILTDARRHTGSHRQWLDLQFDCVQPENYSCLMRYDSATGQEYIHSSLSYQFDGHEVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZ24</accession>
    <name>A0A3P9BZ24_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein ZFMSA12A</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014265058.1">
        <property type="nucleotide sequence ID" value="XM_014409572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZ24"/>
    <dbReference type="Ensembl" id="ENSMZET00005015717.1">
        <property type="protein sequence ID" value="ENSMZEP00005015225.1"/>
        <property type="gene ID" value="ENSMZEG00005011430.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105941242"/>
    <dbReference type="GeneTree" id="ENSGT01150000286944"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11657">
        <property type="entry name" value="TIN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029400">
        <property type="entry name" value="TINF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14973">
        <property type="entry name" value="TINF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="671" mass="75840" checksum="7B3C6D993A9944CB" modified="2019-02-13" version="1">MARTEGPLPPSSLRLLVPPLRVMSAVMWKVVHLKIVKQYGKVEEFVSLVSEAIPDILTSHQVTLLTVGLRAKMILQMLNSEDLGGIKTHLGCLLQTRSRQVYPEGNPLEANIVTFVQRLLDDSEGREHFLKNVFPVAYGPDFDTALEKLLCDFFSKLEELLPVPDFKQAALWISDTPAEVEEYMHCVTEADDIKVLLRTRPRNSEMAKIDSSVPSPSEQRLFSSLSLPVSLIDNSAKDVESNAPTFENQRVSEAAAFQEPRDGDMWDTRWPHEEESHSAEQEAGGKDTDSIPDTHVVEECGDQATTTRQAPSSSAESHVVSSSVIGPLRQRVAQKCTQCGKCFIYKYELLEHQRLHTGENPYKCSQCGKAFRRSSDLSSHRRTQCRKAAYICIKCGKSFQSMQEKCRHQCVHSIHKFDCPYCGKSFKKMYLLAKHKLTHNQNRIFTCRQCGEVYPGISELRSHQKIHPPQLSNQCQQCGKFFSSAACLTAHQLRHTQQRTQICTRCGKAFKSKHDLNLHMRSHTGERPFQCTYCEKRFSVSGNLNVHVRIHTGEKPYLCSDCGKAFISAGELQIHRRTHTGEKPYKCSVCGRGFTRASKVTLHMRVHTGERPYECSECGKGFSRGSELKKHTMNHAGVRPYACQLCAKTYTCLSHLKRHLKSHSVVQSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C1C2</accession>
    <name>A0A3P9C1C2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Nucleobindin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NUCB2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleobindin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C1C2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016033"/>
    <dbReference type="Ensembl" id="ENSMZET00005016546.1">
        <property type="protein sequence ID" value="ENSMZEP00005016033.1"/>
        <property type="gene ID" value="ENSMZEG00005012040.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001927"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000045">
        <property type="entry name" value="Nucleobindin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057576">
        <property type="entry name" value="NUCB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF23">
        <property type="entry name" value="NUCLEOBINDIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25434">
        <property type="entry name" value="NUCB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018242392" evidence="18">
        <location>
            <begin position="31"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="404" mass="48470" checksum="A279B8AA04FBECB9" modified="2019-02-13" version="1">MYALPDQMVRSKALARCGLVLLSLWLCIQSVPISVDKTKEKAKEEELGPPESDTGLHYDRYLREVIEYLEKDPHFREKLKNANMDDIKQGKLSKELNFVQHNFRTKLDELKREEMNRLRMLIKAKHDIKEGNVDHQALLKQFEHLNHKNPHTFEVDDLDRLIKSATNDLENFDKDRHDEFKQYEMMKEHERRQRLKNLNEEDRKKEEEHYEEMKKKHASHPKVNHPGSEDQLKEVWQEADGLDPEDFDPKTFFKMHDSNGDGFFDESELEALFTKELEKVYNPENEEDDMVEMEEERLRMREHVMNEVDTNKDRLVSLSEFMAATKKEEFYEKDEWETLDQNPLYTEEELREFEQQLANEENDINKKSAELQKEREELERKQEELDAQKLGLKQVNYLSTIHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C1C3</accession>
    <name>A0A3P9C1C3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MOCOS</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C1C3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015676"/>
    <dbReference type="Ensembl" id="ENSMZET00005016181.1">
        <property type="protein sequence ID" value="ENSMZEP00005015676.1"/>
        <property type="gene ID" value="ENSMZEG00005011771.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157051"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="1"/>
            <end position="18"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="775" mass="85659" checksum="B73F31211799BE12" modified="2019-02-13" version="1">MLSKALIMGQQLLQLVLCWNKLVKTFSYRVLQHFNTTPEEYSVIFTSGCTAALKLVAESFPWRSHTESQAGSHFCYLTDSHTSVVGMRGLTSSRGVVTQPVSPQELENRAKDEAQVEDVICQTPHLFCYPAQSNFSGRKYPLSHVKGIQARRLYPACAHQGRWFVLLDAASYVSCSPLSLQDCPADFIPISFYKIFGFPTGLGALLVRNDAADILKKTYFGGGTAAAYLSGEDYYVQAANISDRFEDGTVSFLDIIGLNHAFEALYRITGGMHNIQQHTFGLARYTYMLLSSLCHGNGRPVAHIYTEGQFDSPITQGAVLNFNLMDSNGQIIGYSQVDRMANLYNIHVRTGCFCNTGACQSFLGITSQRVKRNLQAGHVCGDNIDIVDGQPTGSVRVSFGYMSTFEDCQKFLNFVAECFVEKPVRVDQERLQELKRAAAASEDSNESPSIKITNGEVYKGDEKKPTEASLKGFQLRDSNSHGVAYTLTNIYIYPIKSCGAYEVHDWPVGPLGLLYDRGWMVVNGNGVCLSQKREPRLCLIRPQVHIRSNKLLLQAPGMETISVPLENNNHSHTRVCHSKVCGDRVETVDSGDEAASWLSDFLGQPCRLIKQRPDFTREMKKRPSEAATSTSLSLVNEAQYLMISRASVELIQNLMSSRQDDSEGDQLLDTQSVISRFRANLVIAGVEPFEEDNWSHLVIGSTQFMIAGHCGRCHMVGIDQDTGSKTKEPLMSLSAYRSGKVTFGVYLTHQLTEGSTAAANVLSVGSLIQPKPNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C280</accession>
    <name>A0A3P9C280_9CICH</name>
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        <submittedName>
            <fullName evidence="5">Proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)</fullName>
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    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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            <taxon>Haplochromini</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_004539427.5"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMZET00005016507.1">
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        <property type="gene ID" value="ENSMZEG00005012014.1"/>
    </dbReference>
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        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="Peptidase_S1_coag_factors"/>
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        <property type="entry name" value="COAGULATION FACTOR"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278:SF38">
        <property type="entry name" value="TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 4"/>
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    </dbReference>
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        <property type="entry name" value="GLABLOOD"/>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
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            <begin position="64"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50998"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="223" mass="25172" checksum="14B12E67AEE89347" modified="2019-02-13" version="1">MSRDCQCAGALMAMLLHLFVLFQFFTCGDLAFVGQLPSENEESQNQVFVDEGHANSFLGRHLLFNRFDFEMFVPGNLERECIEEVCNYEEAREVFENIPDTERFWKEYTADKGGRSSRVDVVALLVGLIAGGVAIVIFGIVVWFLCQRRWKGNLSHESSIRVRQRRSNASLIMRRLEEVSLHPVPPSDDPPGLPSYEQAIARNGPHDAPPPPYPGSRTGSTRQ</sequence>
</entry>
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    <accession>A0A3P9C3U4</accession>
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        <submittedName>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004538779.2">
        <property type="nucleotide sequence ID" value="XM_004538722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3U4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016714"/>
    <dbReference type="Ensembl" id="ENSMZET00005017248.1">
        <property type="protein sequence ID" value="ENSMZEP00005016714.1"/>
        <property type="gene ID" value="ENSMZEG00005012559.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101483811"/>
    <dbReference type="GeneTree" id="ENSGT00940000163886"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01213">
        <property type="entry name" value="PTB_tensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033929">
        <property type="entry name" value="Tensin_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051484">
        <property type="entry name" value="Tensin_PTEN_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734">
        <property type="entry name" value="TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45734:SF6">
        <property type="entry name" value="TENSIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="310"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="575" mass="62568" checksum="9ACEA8E9A4302382" modified="2019-02-13" version="1">MMPTFKGLAHTIPSHVLRVGQTICLEPSQETVTHHDDPDLGISLENLNQLILELDPTFEPIECSKSPTCLSPPADASCSDEDFSEVVLIPRGCSTISSPTVVPSVSPSIPIPTHNGLRCSPQGTLVFSSSPTSSLPPLPFGSAPRRNPSPKNDFCQGSLRLSHSNRNSTASLLSTSTCSDTSYILGSNLSLTGEDADFPESMLSGSFSDNSRMKPCNNRQSLEKPLKTKRGHLQEVNSRRAQNGPVSGSLTDIPVLLVNGAPQQDLHSPEPQIELLQRNPVSKPTYSSSQARFNGSQPSMKFVMDTSKFWFRPHISRAEAEALVKDKEAGTFVVRDSTSYRGSFGLAMKVDQTPTSFTAAAYPGESSSDLIRHFLIESSAKGVRIKGSSQEPYFGSLSALVYQHTISAYALPCRLCLYCHDLRSAEERAKERAPSEDDNKIASNFVYLNAIPTEMLTGPCAVQRAVSSTLEKAPGSFTPTIVNMKVSLKGVTLTDINRKLFFRRHYPAHMLSYGGEDPDNRVWTRGSSFGARLFGFVAKGIEAGMENVCHVFAEYDTLQPCSEVIKVIQAAVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4Q4</accession>
    <name>A0A3P9C4Q4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ileal sodium/bile acid cotransporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Apical sodium-dependent bile acid transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ileal Na(+)/bile acid cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ileal sodium-dependent bile acid transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Na(+)-dependent ileal bile acid transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 10 member 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="33 34">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71911"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29747"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71935"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29746"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>tauro-beta-muricholate(out) + 2 Na(+)(out) = tauro-beta-muricholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72179"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:133064"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tauroallocholate(out) + 2 Na(+)(out) = tauroallocholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:51840"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:191406"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>taurochenodeoxycholate(out) + 2 Na(+)(out) = taurochenodeoxycholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71923"/>
            <dbReference type="ChEBI" id="CHEBI:9407"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>taurocholate(out) + 2 Na(+)(out) = taurocholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71875"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:36257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>taurodeoxycholate(out) + 2 Na(+)(out) = taurodeoxycholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72087"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:36261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>tauronorcholate(out) + 2 Na(+)(out) = tauronorcholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71915"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:191405"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>tauroursodeoxycholate(out) + 2 Na(+)(out) = tauroursodeoxycholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71927"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:132028"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4Q4"/>
    <dbReference type="Ensembl" id="ENSMZET00005017817.1">
        <property type="protein sequence ID" value="ENSMZEP00005017270.1"/>
        <property type="gene ID" value="ENSMZEG00005012959.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182808"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008508">
        <property type="term" value="F:bile acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000010">
        <property type="entry name" value="Solute carrier family 10 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00841">
        <property type="entry name" value="bass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF19">
        <property type="entry name" value="ILEAL SODIUM_BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0915">Sodium</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="7 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 32" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00046038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="375" mass="40540" checksum="245808C5D1D3E90F" modified="2019-02-13" version="1">MSTLKPTTMLPAICDNAATACSGTDCLVPPSNFNAILGVVMSTVLTIMLAMVMFAMGCRVEAAKLWGHIKKPWGIIIGFLCQFGIMPFTAFALSLAFGVQAVQAVVIIIMGCCPGGSISNIICYWLEGDMDLSLSMTACSSLLALGMMPLCLLIYTSVWTSSDTIKIPYDSIGITLAALIIPIGVGMYVKHRWPEMAKKILKVGSIVGLVLIVIIAVIGGVLYQSSWTIAPSLWIIGTIYPFIGLSLGFFLARFVGQPWYRCRTIALETGIQNVQLCSTIVQLSFSPEELETMLAFPLIYSIFQLVSALVFVGCFQLYKRFCGGSSTNSDATYLEGQNADVEEQKHCPQENGGFEGDESNNTDVKDKSTDKSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8D4</accession>
    <name>A0A3P9C8D4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Docking protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOK family. Type A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538720.3">
        <property type="nucleotide sequence ID" value="XM_004538663.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8D4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018171"/>
    <dbReference type="Ensembl" id="ENSMZET00005018760.1">
        <property type="protein sequence ID" value="ENSMZEP00005018171.1"/>
        <property type="gene ID" value="ENSMZEG00005013649.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101468029"/>
    <dbReference type="CTD" id="559168"/>
    <dbReference type="GeneTree" id="ENSGT00940000155980"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01203">
        <property type="entry name" value="PTB_DOK1_DOK2_DOK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037751">
        <property type="entry name" value="Dok1/2/3_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF46">
        <property type="entry name" value="DOCKING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="4">
        <location>
            <begin position="144"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="483" mass="53069" checksum="8F94692CFDA5FCAB" modified="2019-02-13" version="1">MDAQTKSGKVYLQPHKPGKKWKPVWLSLTPPSSSGVGRLEIQDMGGGDLATGVRKHGDRRVKVVRLSELISVLRLPPNAEACPMENMWAFCVETQDRTMVFAALRDDCADWVDKLCQSTFQKGGRPRSNQPQMEENQIYVSVEEASEFWVAIQRTEAATRCGLQGAYWLQVGREALLLKETQKKKVVHEWAYELLRRYGNDKLTLTIEAGRRCDSGPGAFIFETPQAEKIFALIQSTIKLKTSSTNQNPEGEKVAVTNIQAHSPLPKVPDMTNMAAILENKLRTEESREESAHAREDHPPPITLMPLPLVPAGSSAGNHGDQSEAIYANPTDCIRPVTKPPPVRATYIDPASVLPLKPPCAAPHPPPCADDPDSVYSEVYDKVGHHQNTDNFLQKKEETKVSAEGDAVYAQPGRRSEVSLKSEAKADPFAHLYAHVCKKAPSSSPSSSNDSTPSSSSPIANRSTTKASDCPLDDVIYENLGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8H8</accession>
    <name>A0A3P9C8H8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8H8"/>
    <dbReference type="Ensembl" id="ENSMZET00005018801.1">
        <property type="protein sequence ID" value="ENSMZEP00005018211.1"/>
        <property type="gene ID" value="ENSMZEG00005013676.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167101"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00098">
        <property type="entry name" value="IgC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
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    </dbReference>
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        <property type="entry name" value="IGc1"/>
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    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="51"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="187" mass="20924" checksum="89895AC10B757652" modified="2019-02-13" version="1">TTAEGILEASGCFLETEEMVAEIPRNKQIIEYVLIMILNYRSSDKLGMSSPTLSVPHQWVVLDTKTQLKCHADGFYPPPVSFSWTRAGEVIQPPYQVEVELTPDGYYRAVGNLTFYPSHEDQNVTFGCKVSHSGNYQELDFQLSITRESLRVTVSILVALMPHGLSVFLTVLLILHPLSLHNVTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8X0</accession>
    <name>A0A3P9C8X0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="11">HIBADH</shortName>
            <ecNumber evidence="11">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004541542.1">
        <property type="nucleotide sequence ID" value="XM_004541485.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8X0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018718"/>
    <dbReference type="Ensembl" id="ENSMZET00005019319.1">
        <property type="protein sequence ID" value="ENSMZEP00005018718.1"/>
        <property type="gene ID" value="ENSMZEG00005014049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485952"/>
    <dbReference type="KEGG" id="mze:101485952"/>
    <dbReference type="CTD" id="394135"/>
    <dbReference type="GeneTree" id="ENSGT00940000155255"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000119">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF82">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="12">
        <location>
            <begin position="34"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="13">
        <location>
            <begin position="196"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="329" mass="34744" checksum="6CE0F7D64B939283" modified="2019-02-13" version="1">MAAVLRGSRYLVGRCCKHVDFVFVSTRSMASKTQVGFVGLGNMGNPMAKNLLKHGYPVIATDVFPESCKEVQELGAQIVDNPAEVAEKADRIITMLPSSPNVIDVYTGPNGILKKVKKGSLLIDSSTIDPAVSKEMAADAEKMGAVFMDAPVSGGVGAASSGKLTFMVGGAEEEFTAAKELLSCMGANVIYCGQVGTGQAAKICNNMLLAIGMIGTSETMNLGIRLGLDPKLLAQILNMSSGRCWSSDTYNPVPGVMEGVPSGNNYQGGFGTQLMAKDLGLAQNTATNTKTPVPLGSLAHQVYRMMCARGYGNKDFSSVFQFLREEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9H3</accession>
    <name>A0A3P9C9H3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9H3"/>
    <dbReference type="Ensembl" id="ENSMZET00005019535.1">
        <property type="protein sequence ID" value="ENSMZEP00005018928.1"/>
        <property type="gene ID" value="ENSMZEG00005014203.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182912"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF27">
        <property type="entry name" value="SI:CH211-193K19.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="119" mass="13336" checksum="E5B82D181AFAEB51" modified="2019-02-13" version="1">GRRSHLKQLFLFLKDGADAVFVEEALAEEVMKIYLLQNQDRSGEPTDVGIVIEGVTVLGKLGNLSKACCYLLGLCYALDLKYPKNFKCTFEAFQKVFMELDPGNLSVKVQRLKNDLCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9U9</accession>
    <name>A0A3P9C9U9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9U9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018676"/>
    <dbReference type="Ensembl" id="ENSMZET00005019277.1">
        <property type="protein sequence ID" value="ENSMZEP00005018676.1"/>
        <property type="gene ID" value="ENSMZEG00005014019.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167611"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="143" mass="16373" checksum="A50840B137E3DB0A" modified="2019-02-13" version="1">QQKEEEEKRNEMEPTRRRESVCRSLFGPVDHSQLRRDLKLKLKEIIEQDRRRWNFNFECETPLPGRFQWEEAARPKDAAHRSGGDRPSDGEDGAGTDQENCSNITNKRKSPTEGSPNRQPVSKTIVGVSALKNFKRPSGLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAJ9</accession>
    <name>A0A3P9CAJ9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcineurin B homologous protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Tescalcin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the calcineurin regulatory subunit family. CHP subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAJ9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019315"/>
    <dbReference type="Ensembl" id="ENSMZET00005019939.1">
        <property type="protein sequence ID" value="ENSMZEP00005019315.1"/>
        <property type="gene ID" value="ENSMZEG00005014485.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155845"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052490">
        <property type="entry name" value="CHP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46823">
        <property type="entry name" value="CALCINEURIN B HOMOLOGOUS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="226" mass="26452" checksum="AC12FE520287AF9F" modified="2019-02-13" version="1">MYNYKHYCKNLHKYIHIVDVCFFTVSQEQIKNLYQRFQQLSGNHEKISRDDLERIPALNNNPIRKQIITAFFDKRNQHQNDVGSLDEIGFEQFLMVMSHFRPVNSTATEEEKVTVRKQKLRFLFNMHDTDNDGIITLDEYRTVVEELLSQSGAIETEVARSIADAAMLEVASTNVHSPHSRPRMISMKESHLSILNRFRWINIFSMMSIRFLDMNSATMRCGKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBT9</accession>
    <name>A0A3P9CBT9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger BED domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBT9"/>
    <dbReference type="Ensembl" id="ENSMZET00005020102.1">
        <property type="protein sequence ID" value="ENSMZEP00005019474.1"/>
        <property type="gene ID" value="ENSMZEG00005014626.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158431"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1070">
        <property type="entry name" value="Zinc finger, BED domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="11">
        <location>
            <begin position="496"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="630" mass="71395" checksum="A43A7D98292CDA48" modified="2019-02-13" version="1">MDEGGLLGGKFLFKKLPDGLLDKTRVRCTICKAEFKYHRSSSSLAYHLRAKHPTESTSTGPRQSTLQEYGACGRITKNVREKVTNSLVVWIAKNCRPVSIVEDDGLREVIRAASGDECYNLPSRGTIVSRLHTLYGDQRAQQSSKLVQVRNVALTGDHWTSVNNDNYLGVMAHFIDNDWTMQSFALTVSKTEERHYAEACADHFLNVANEWKIKDKVTTLGTDSARNMVAAARLLPFEHMPCMAHILQRTVTVSLNDSAFERALAKCRKIVGHFKHSPANAQELKAQQAAHGHQTEPLVQDVPTRWNSTLEMIKRIQRNKFGLTTILTQQNSKVTMLTDQELDRLQKLEELLEPCRYVTELLGGERYVSCSMVLPALCHLFRIMEPSDDDPVYVLRFKKIFTTDLAQRRDSSNLTWLKIATALDPRFKDLKCLSKDERREVWASVHDLLMSETDAHQPSAQTTEEPSPKKSKMSICLLGSPDSDTEEEEDAIDCCLNLYKAEPKIDIGECPLQWWLKREGAHARLAPIARKYLSTPATTVPCERLFSLSGHIIQKKRASLSSDNVNRIVCLSNWLSSAILDTTFVFSIGRGPCDTSNLLVMSQEKQWCAWFQHNFILSRVIYKLLFVHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCY3</accession>
    <name>A0A3P9CCY3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleolar transcription factor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004575500.2">
        <property type="nucleotide sequence ID" value="XM_004575443.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CCY3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019869"/>
    <dbReference type="Ensembl" id="ENSMZET00005020513.1">
        <property type="protein sequence ID" value="ENSMZEP00005019869.1"/>
        <property type="gene ID" value="ENSMZEG00005014921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463832"/>
    <dbReference type="KEGG" id="mze:101463832"/>
    <dbReference type="GeneTree" id="ENSGT00940000167603"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22001">
        <property type="entry name" value="HMG-box_UBF1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051762">
        <property type="entry name" value="UBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318:SF2">
        <property type="entry name" value="NUCLEOLAR TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="303"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="202"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="303"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="450" mass="53383" checksum="D037142283FB8BA5" modified="2019-02-13" version="1">MSLAGKNAEESGWCKKNLQKLLAAMKANILDDKKELSYTHGERTLDWEKVAFPPFSPEECKQKWKEVIQKMRKVRNLTELIVEAESVLSDPLNNAKLHPEYPKRPMPVNTWYYKEVFSKIKKKNPGMSCAGLMKIASKEFSLLPDKKKAFYLEKYRNAYKEFTNKRVELREKYGKSLQKSKRKKVVPESTSESEEDFEGLPVKPPISGYNLFCKELIGSMSVPTRAYIKEWSQRWRNLSEKERKAYNTRSKELKMRYESEMHTYLMSLDEEKRNKVLRKTKISFPTKRKIFKRKTKEKIPGEPKMPSMSVNVAFCQDQMKILKEKIPNAKDRFAAANKKWHELSIKDKSRYQLKVNEKLRKYSIELQEWFKTLTPDEQNEYQKQNPRKLKYLEDTLPKYSDKDELFLKQPSDSEDEIIESSSDDEDDNILDFDEDDDEEEEEDDIMFDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDA4</accession>
    <name>A0A3P9CDA4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat and death domain containing 1B</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDA4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020117"/>
    <dbReference type="Ensembl" id="ENSMZET00005020764.1">
        <property type="protein sequence ID" value="ENSMZEP00005020117.1"/>
        <property type="gene ID" value="ENSMZEG00005015079.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154170"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052457">
        <property type="entry name" value="Ankyrin-DD_containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24125">
        <property type="entry name" value="ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24125:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="376"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="461" mass="51528" checksum="2C7ABDCF577DA96E" modified="2019-02-13" version="1">MTDLGKGLNANVKNVQNRTALHFAVACTNKEAVKLLLQRRVKVDQKDKYGVAPIHLAAWFGSLDILKLLVQAGAEQKAENEEGLNILHCAAINNHTEIVDYIVNDLQMKELDKDDLSGHRAFALAAEHGCVKMLQVLMEPYNMATMKPNKVCTRTYLCDFSLKVKHSLIGDTPLHLAADHGQEECAQVLLEAGCDPNILTVAKCSALHTVAEKGDAALVQVLLQYNAQADFQNQDLETPLHLAVKNSHIPVIYYLLEAGCNINATDKRSQTAMHIAAETAKAEVVEMLLKAGPDITVKDRQGKTALGVAARADEVNIVDMIIKAERYYDQKKANPELNEIVRTEHALTFKFDRRSENKELYSMAWRLAYKLLKPGDWKRLATHWDFTQDQVSAIEEQWTGQHSYQEHGNRMLLIWLHGEELALKAPAKDLYQGLICTGNTKTADKIRLEAEQVSSKRCTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CES0</accession>
    <name>A0A3P9CES0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cystinosin, lysosomal cystine transporter</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004565017.1">
        <property type="nucleotide sequence ID" value="XM_004564960.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004565018.1">
        <property type="nucleotide sequence ID" value="XM_004564961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CES0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020755"/>
    <dbReference type="Ensembl" id="ENSMZET00005021437.1">
        <property type="protein sequence ID" value="ENSMZEP00005020755.1"/>
        <property type="gene ID" value="ENSMZEG00005015570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476768"/>
    <dbReference type="KEGG" id="mze:101476768"/>
    <dbReference type="CTD" id="1497"/>
    <dbReference type="GeneTree" id="ENSGT00390000005338"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000022">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018253938" evidence="12">
        <location>
            <begin position="28"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="381" mass="43216" checksum="5131B967DBD379A5" modified="2019-02-13" version="1">MTGQGLGKRCLPAQLLVFWMLTNMSESRLSLFAPQAVTLEEYSKNAVVITSSSPLNQSAVIHLNVTHSSKINYSSIITVPEEVMMPVQATAVSFNVTAHDVGQVTTYLVTNSTELNSVPVRIRFIVVHSNVLSIISEVIGWIYFLAWSVSFYPQAFENWRRKSVVGLNFDFLALNLTGFIAYSVFNIGLFWIPSIKEEFLKRNPNGINPVTANDVFFSLHAVLLCLVYFSQATVYERGGQRVSRTALVLLLIGWMFALISLFVAVAKTITWLDYLYYFSYIKLAVTLIKYVPQAYMNYKRQSTEGWSIGNVLLDFTGGFFSILQMILQSYNNDEWKLVFGDPTKFGLGLFSIVFDILFITQHYVLYRRSSQYEPLVNQQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF43</accession>
    <name>A0A3P9CF43_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CF43"/>
    <dbReference type="Ensembl" id="ENSMZET00005021594.1">
        <property type="protein sequence ID" value="ENSMZEP00005020908.1"/>
        <property type="gene ID" value="ENSMZEG00005015696.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000182013"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="73" mass="7858" checksum="3CF5765E4E720B2F" modified="2019-02-13" version="1">ITRDASFNARDALISPSANRLTLARASRVASASDAMSSVALSRKGKNGKRKTPGWKKLIWACAVNISAMWPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGP9</accession>
    <name>A0A3P9CGP9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Binds calmodulin. Interacts with NDUFAF3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDUFAF4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004566266.1">
        <property type="nucleotide sequence ID" value="XM_004566209.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGP9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021204"/>
    <dbReference type="Ensembl" id="ENSMZET00005021902.1">
        <property type="protein sequence ID" value="ENSMZEP00005021204.1"/>
        <property type="gene ID" value="ENSMZEG00005015921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475604"/>
    <dbReference type="KEGG" id="mze:101475604"/>
    <dbReference type="CTD" id="29078"/>
    <dbReference type="GeneTree" id="ENSGT00390000001627"/>
    <dbReference type="OrthoDB" id="2434756at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338:SF4">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338">
        <property type="entry name" value="UPF0240 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06784">
        <property type="entry name" value="UPF0240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="177" mass="19731" checksum="D1D38C71A4FF68AB" modified="2019-02-13" version="1">MGARVTRVFRNYNLENRVHRELSKDKPRAAPRHSVKLPPTASSPQEVDSLNQNNAPLLDHLRSVYVESRDPAPAAAEVSKDVTAGREQRRLLKFSVPASPLGLVELTDVPIGKLTIAEALKAVGSHQHQPQTWSPEKIAQEYSLDLKETKALLDFFVPFKVEIIPPKTKKTKQIKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGZ6</accession>
    <name>A0A3P9CGZ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable D-lactate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in D-lactate, but not L-lactate catabolic process.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGZ6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021131"/>
    <dbReference type="Ensembl" id="ENSMZET00005021828.1">
        <property type="protein sequence ID" value="ENSMZEP00005021131.1"/>
        <property type="gene ID" value="ENSMZEG00005015846.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158705"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="probable D-lactate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="72"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="503" mass="54597" checksum="51AF6D2804B97A0D" modified="2019-02-13" version="1">MVLKALEISKSIMLSTCRLTQKALHFLCKSHISKHCGVGDSVLSAFRSICGEDGVSLGEAVREQHGKDESVHRCRPPDVVVFPRCVEEVSALAKVCHKHRLPIIPFGTGTGLEGGVGAMKGGVCFSLRNMEQVLDLHPEDFDVTVEPGVTRKTLNAYLRDTGLWFPVDPGADASLCGMAATSASGTNAVRYGTMRENVINLEVVLADGSVVHTAGKGRRPRKTSAGYNLTNLFVGSEGTLGIITKTTLRLYGIPEAMVSAVCSFPSVQAAVDSTVQTLQAGVPIARIEFLDDVMIDACNRFSSLSYPVTPTLFLEFHGSEQSLEEQVSVCVSTEDITQSNGGSDFQWARDTETRNRLWKARHDAWYAALALRPGCKAYSTDVCVPLSRLPQIIVETKEDLIENRLTGPIAGHVGDGNFHCLMVVDPNDPEEMHRVHLFTERLARRALAMDGTCTGEHGVGLGKRALLCEEMGPVGIQVMQSLKDALDPNNLMNPGKILQREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHJ8</accession>
    <name>A0A3P9CHJ8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CUGBP Elav-like family member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHJ8"/>
    <dbReference type="Ensembl" id="ENSMZET00005022035.1">
        <property type="protein sequence ID" value="ENSMZEP00005021331.1"/>
        <property type="gene ID" value="ENSMZEG00005016013.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154716"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12632">
        <property type="entry name" value="RRM1_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12635">
        <property type="entry name" value="RRM2_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12639">
        <property type="entry name" value="RRM3_CELF3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000060">
        <property type="entry name" value="CUGBP Elav-like family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000007">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000010">
        <property type="entry name" value="CUGBP Elav-like family member 4 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034648">
        <property type="entry name" value="CELF3/4/5/6_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CI49</accession>
    <name>A0A3P9CI49_9CICH</name>
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        <submittedName>
            <fullName evidence="9">SRY-box transcription factor 7</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Cichliformes</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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    </dbReference>
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    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
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            <end position="111"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CIV7</accession>
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        <submittedName>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Haplochromini</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
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                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="gene ID" value="ENSMZEG00005016676.1"/>
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    <dbReference type="OrthoDB" id="191139at2759"/>
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        <property type="component" value="LG1"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF72">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
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    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="286" mass="31322" checksum="954BCF78A4C2B038" modified="2019-02-13" version="1">MMKGKTVIVTGANSGIGKATAAGIVKLQGRVIMACRDLDKAEEAARDIQQGTGAESTQLVVKQLDLASLTSVRAFCEDIIKEEPRLDVLINNAGIYQCPYTRTEDGFEMQFGVNHLGHFLLTHLLLDLLKRSAPSRIVVVSSKLYKHGYINFEDLSSEKSYDKAFAYSRSKLANLLFTCELARRLEGSGVTANAVTPGIVRTNLGRHVHIAVFVRPLFDLLSRSLFRSPEEGAQTSVYVASSPDVDNVQGKCFADCQPQVLLDKATDQELAAKLWDISEVMVGIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJA3</accession>
    <name>A0A3P9CJA3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deleted in malignant brain tumors 1 protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJA3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022370"/>
    <dbReference type="Ensembl" id="ENSMZET00005023115.1">
        <property type="protein sequence ID" value="ENSMZEP00005022370.1"/>
        <property type="gene ID" value="ENSMZEG00005016762.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163723"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
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    </dbReference>
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        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
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        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
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        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF59">
        <property type="entry name" value="CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018231951" evidence="6">
        <location>
            <begin position="22"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="7">
        <location>
            <begin position="378"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="742" mass="81869" checksum="69BD8EB043C0A82F" modified="2019-02-13" version="1">MEAGVFLLLLFPLLGIGSTLSFYGDSISFMAPEKEMDGTFKVTFYHRQNGKSNCQDQSSFSCDSGVCAGFNESSVLQTDQDSTGQGRWCQSEGHTTATILTNNASLSLRNSGCCWVSNVEGKTQWTTYAELDLGTRSDTHTVNSCPVTTTVSSLRVPQNCFSRIRILAHDPDGDEVKCRFATPGPTNFALDETTCILTSTGDIETGIHVFELMLEDFSTNNITLTYSDGTSVFREASGMNSPPLCKVKLQFSIEVLLPIPNCEAGHVQPIFLYRTPSHGDILHATVGQTFQLNAEAEARHASIHDFQVSGPQNMTKVFKDDLLGKAEVTLSWTPQLSDLYRYVPVCFTAETNDTQSEMRCVVVLVTQASTTQGKATVHCSANKMTVALDKASMPGIDENFLKLSDPSCSLTSNSTHIMGAMSFSTCGTKIEDKGDYIIFKNAINSFELANEVITRRKTVKIGFSCQFPKAISISNYYNLHNADYIFTESNFGSFGYTFEIFYNSSFTNRVEASAYPVQVKLLETIFMGIQASSELPNVMLFVESCKATPDNNPENSLSYYIIRNGCVEDETVTIYPSNKTAFNFGLQAFKFTGNYDQVYITCSVILCEPESPFSRCAQGCLKDPSRRRRRGLSGETGRHYITQGPLQFVGQPFPDTAENSQDVLMERSGTLPEVSPPPASPGTKSSEEGWEMRKIFSSNISTAVFASAFLVSVVLLGIMARYYRKNGRAEDRKVLIASEWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJB0</accession>
    <name>A0A3P9CJB0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 8 member B1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_023011165.1">
        <property type="nucleotide sequence ID" value="XM_023155397.2"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005022237"/>
    <dbReference type="Ensembl" id="ENSMZET00005022980.1">
        <property type="protein sequence ID" value="ENSMZEP00005022237.1"/>
        <property type="gene ID" value="ENSMZEG00005016679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472889"/>
    <dbReference type="GeneTree" id="ENSGT00940000157433"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099093">
        <property type="term" value="P:calcium export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
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    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="390"/>
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            <begin position="101"/>
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        <location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="584" mass="64551" checksum="0B6AC2146F8315E5" modified="2019-02-13" version="1">MFCGIFLPLFVVLPCGWQLTSGSELLRNESGVRVGMAGRWSENNNNDECDLVMNYSVADRCAFVKKTPDCSMEDGFINYLEVAFCLLPPNLTPLTISFCIIWLFFLFIILGLTASKFFCPNLSAISSSLRLTHNVAGVTFLALGNGAPDIFSAIAAFSHPHTAGLAVGALFGAGIFVTTVVAGSVALVKPFAVASRPFLRDVIFYMVAVFWTFLILYRGTVTLGETLGYLGLYVLYVVIVIISAFIYNRQKYSDNTSVQNVTHVPDFHSSDSSDDDVPCLTGRSIHQEYESEYRPLLPYSESTSQILLSSLNPVDNRRWRRKSWKWKVLKVFKTPLEVLLLLCIPVVDPDKEDRNWRRPLNCLHLITAPLVCVLVFQSGAYGNYMIQGQFPLWLLFLLLGLFVSAIVFCSTSNDCPPRYHSFFALLGFVVSAVLISAAASEVVSLLHMLGVVLRLSNTVLGLTLLAWGNSIGDCFSDITIARQGYPRMAISACFGGIIFNMLFGVGLGCLVQMLQTHADVQVEPEGLLTWILAGSLGLSLVLSFVIVPLCRFHLGRAYGIFLLIFYVIFLIIALLTEFGKIRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQ43</accession>
    <name>A0A3P9CQ43_9CICH</name>
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        <submittedName>
            <fullName evidence="3">INO80 complex subunit E</fullName>
        </submittedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004550860.4"/>
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    </dbReference>
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        <property type="gene ID" value="ENSMZEG00005018301.1"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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            <begin position="10"/>
            <end position="57"/>
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    </feature>
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    </feature>
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        </location>
    </feature>
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            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24237"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="236" mass="26264" checksum="D821962A0E4E4E1E" modified="2019-02-13" version="1">MNGQADVEVDYKRKYKNLKRKLKFLVYEQECFQEELRRAQRKLLKVSRDKSFLLDRLLQYERVDEDSSDSEATVSSENSEGEGPREREREREGAKKRKSSPGACLPSSSSPHLSLLSRPGVNSLQSSGSGAYLNAMPFPPEYLAPPAERMKKERKTKTAKNKKETTGKVVTSMAANYPSGPAAPPTASGHFSWVPRQMFSGDAAEEEGESDGDSDRGDEDRGEGDEAELVIDIPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CS04</accession>
    <name>A0A3P9CS04_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/potassium/calcium exchanger 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CS04"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025135"/>
    <dbReference type="Ensembl" id="ENSMZET00005025953.1">
        <property type="protein sequence ID" value="ENSMZEP00005025135.1"/>
        <property type="gene ID" value="ENSMZEG00005018761.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234532"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000037">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000005">
        <property type="entry name" value="sodium/potassium/calcium exchanger 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF42">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="331"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="498" mass="54952" checksum="C089C94584D22D8E" modified="2019-02-13" version="1">AVYMFYALALVCDDYFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGIFAVQTIRLSRWPLLRDSVYYTLSISALIVVRSTLRLNSYIVRFLGRRKKNSTTLRNGAANNTELDDGCDATAVLLKKANHHRKTSVLMVDELLSAYPHQLSFSEAGMRIMITSHFSPRTRLTMASRMLITERQRLINTRTLTNGDSEVPVKGGSRWGIENGLSGAERGVGVRRDDREAGNETDNEDNENNENDEEEEEEEGEGPYVPFQCPAGGFNKLKWLLAWPLALLLFFTIPNSSTPRWENWFMLSFVASTLWIASFSYIMVWMVTVIGFTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILVGLGLPWALKTLAINYGSDIKLNSKGLIFSVGLLLASVFMTVLGVHLNNWTLNKRLGFMCLILYSIFVCFSCLIEYNIFTFVNLPTCRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSM3</accession>
    <name>A0A3P9CSM3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ELL associated factor 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024661291.1">
        <property type="nucleotide sequence ID" value="XM_024805523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSM3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025079"/>
    <dbReference type="Ensembl" id="ENSMZET00005025896.1">
        <property type="protein sequence ID" value="ENSMZEP00005025079.1"/>
        <property type="gene ID" value="ENSMZEG00005018727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486665"/>
    <dbReference type="KEGG" id="mze:101486665"/>
    <dbReference type="CTD" id="55840"/>
    <dbReference type="GeneTree" id="ENSGT00390000017724"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070016">
        <property type="term" value="F:armadillo repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042074">
        <property type="term" value="P:cell migration involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060028">
        <property type="term" value="P:convergent extension involved in axis elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060029">
        <property type="term" value="P:convergent extension involved in organogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001714">
        <property type="term" value="P:endodermal cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007501">
        <property type="term" value="P:mesodermal cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014812">
        <property type="term" value="P:muscle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031016">
        <property type="term" value="P:pancreas development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030111">
        <property type="term" value="P:regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF7">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="259" mass="28089" checksum="9C7D2EC23AC37285" modified="2019-02-13" version="1">MNGTAYSNFDNQEHVLKLGETFEKHPKSAYHTVRYDFKPASIDTSCEGELEVGKGEQVTITLPNLEGSSAPVTVFKGSKRPYMKECILIVNHDTGEYRLEKLNSNIAVKKTRAEGSSKIHSRLEQQTSRLGQQMRSNNSSSNKTPASTKSSPPKEKTSPASPMDDIERELMAEARVMDQMSSSDSSSDSNSSSSSSSDDSSSSSDSEDERTSAAPSVNHSMPIITSTDSNSHHHESGGGLMNTLKNDLQLSESGSESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CU34</accession>
    <name>A0A3P9CU34_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trinucleotide repeat containing adaptor 6B</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with GGCX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Sarcoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CREC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553337.1">
        <property type="nucleotide sequence ID" value="XM_004553280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CWS2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026788"/>
    <dbReference type="Ensembl" id="ENSMZET00005027649.1">
        <property type="protein sequence ID" value="ENSMZEP00005026788.1"/>
        <property type="gene ID" value="ENSMZEG00005019980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466729"/>
    <dbReference type="KEGG" id="mze:101466729"/>
    <dbReference type="CTD" id="394057"/>
    <dbReference type="GeneTree" id="ENSGT01010000222360"/>
    <dbReference type="OrthoDB" id="293868at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0033018">
        <property type="term" value="C:sarcoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000090">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000109">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000110">
        <property type="entry name" value="calumenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF87">
        <property type="entry name" value="CALUMENIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017935503" evidence="19">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="315" mass="37283" checksum="E53C4729CA09BC2E" modified="2019-02-13" version="1">MELRPLIMCFALCVVYATSKPTDKKDRVHHDEPLSSREHDDTENFDYDHEAFLGQEEAKTFDQLTPEESKERLGMLVERIDEDKDGYVTVEEMKKWIKHAQKRWIYDDVDRQWKSHDLNGDNVVSWEEYKNATYGYILDDPDPEDGFSYRQMMARDERRFKMADQDNDMKANKEEFTAFLHPEEYDHMKDIVVLETMEDIDKNGDGLIDLDEYIGDMYNQEGDTSEPEWVKTEREQFTEFRDKNKDGKMDKEETRDWILPSDYDHAEAEAKHLVYESDADKDGHLTKAEIVDKYDLFVGSQATDFGEALTRHDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D0L8</accession>
    <name>A0A3P9D0L8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005028133"/>
    <dbReference type="Ensembl" id="ENSMZET00005029029.1">
        <property type="protein sequence ID" value="ENSMZEP00005028133.1"/>
        <property type="gene ID" value="ENSMZEG00005020983.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074802"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01460">
        <property type="entry name" value="vWA_midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000764">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000919">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000956">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000028">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="4736"/>
            <end position="4936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="3898"/>
            <end position="3918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4040"/>
            <end position="4638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="3898"/>
            <end position="3913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4055"/>
            <end position="4093"/>
        </location>
    </feature>
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        <location>
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</entry>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="115" mass="13092" checksum="778059A5B3267755" modified="2019-02-13" version="1">MLNVKEQRIYQATKPQYSLDTESGVLELTVLGACQCAFDTEPCPCSRTAAASRKQLVQLQQETGSDLWICPFLNSFGKINPCIRLKTLQRTKDKGLDLPNFQQHFLAHRLHLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3R6</accession>
    <name>A0A3P9D3R6_9CICH</name>
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        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
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            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3R6"/>
    <dbReference type="Ensembl" id="ENSMZET00005029759.1">
        <property type="protein sequence ID" value="ENSMZEP00005028847.1"/>
        <property type="gene ID" value="ENSMZEG00005021525.1"/>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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        <property type="entry name" value="C-type_lectin-like"/>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
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        <property type="entry name" value="CTDL_fold"/>
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    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER K-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
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        <property type="entry name" value="CLECT"/>
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        <property type="entry name" value="C-type lectin-like"/>
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    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="134"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="237"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="353" mass="42248" checksum="D0EC68B71303A429" modified="2019-02-13" version="1">MSDVKHFNSGCLLCFVSTCYLYEYHFIREDKTWEEAQKYCRENYADLASVFDMADMARLHESKEYEGKAWIGLFSNPGKENRMWHWSLPGVNYTEHETRWGASEPDDQNQNENCVKTRGNWTHARCDQMMPFICYDGENMWIIAQNYCRDHYTDLASGLDQVDGQEFKILKKSQDLWIGLFRDTWRWSDGSNFSFRHWDMESFNDGQNKKKCASTLLNRSRKWSSDECNKKKYFFCYGDKLILINENKTWEEALDYCRLYHTDLVSITNPHQQRWVERRAKNASSPYIWVGLRYTCVMDLWFWISDKLVCYENWADNGKIEECGRCAAMERGGRYQWVSQREHEKYNFICSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4I6</accession>
    <name>A0A3P9D4I6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LHFPL tetraspan subfamily member 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4I6"/>
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    <dbReference type="Ensembl" id="ENSMZET00005030411.1">
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        <property type="gene ID" value="ENSMZEG00005021993.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050811">
        <property type="term" value="F:GABA receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097112">
        <property type="term" value="P:gamma-aminobutyric acid receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF14">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="217" mass="24002" checksum="9E38CD523E2B819C" modified="2019-02-13" version="1">MLPSQEASKIYHDNYMRNSRAIGVLWAIFTICFAIVNVVVFIQPYWIGDSVNTPQAGYFGLFHYCVGTGPSPSRELTCVGSFSDFSSIPSGAFKAASVFVLLSMVLILSCIACMALFFFCNTSTVYKTCAWMQLLCGVCLVLGCMIFPDGWDAEVIRDMCGEQTGKYSLGDCSVRWAYMLAIMGILDALILSFLAFVLGNRQTDFYLDDLQTDNKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D560</accession>
    <name>A0A3P9D560_9CICH</name>
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        <recommendedName>
            <fullName evidence="3 12">Histone deacetylase</fullName>
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        </recommendedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 12"/>
    <dbReference type="RefSeq" id="XP_004575008.1">
        <property type="nucleotide sequence ID" value="XM_004574951.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D560"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029347"/>
    <dbReference type="Ensembl" id="ENSMZET00005030268.1">
        <property type="protein sequence ID" value="ENSMZEP00005029347.1"/>
        <property type="gene ID" value="ENSMZEG00005021888.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475151"/>
    <dbReference type="KEGG" id="mze:101475151"/>
    <dbReference type="GeneTree" id="ENSGT00940000159065"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11681">
        <property type="entry name" value="HDAC_classIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDAC4/5/7/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364:SF13">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364">
        <property type="entry name" value="HISTONE DEACETYLASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037911">
        <property type="entry name" value="HDAC_II_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="17">
        <location>
            <begin position="598"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="70"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="144"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="434"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="727"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Contributes to catalysis" evidence="15">
        <location>
            <position position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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            <dbReference type="ARBA" id="ARBA00022853"/>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
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    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029347.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109160" checksum="141BF148DE28B7DF" modified="2019-02-13" version="1">MFTRQTDGIGTSGNIVKTDRQDSVLPTVADSSVAVAVSRTSLLFPMDLRVGERGMRPGSDTVLLTPLHPPLHLSPFSPQPRSSFSQQQLHQQIRFNMEQRRREHEHHEKQQELQQLKHKDKSQQSAVASSLVKQKLQEVILKKQKKAELERTNANSLTAPPVQYRKLGPDPSIPTLVSSSTQPPHEGPEGTPLRRAASEPNLKVKNKLKKHLNTRKSPLTRKDSAPPTVKHRVPDTLDSSPSSSSTPVSGCSSPNDSLPNENGLLPSAGGLSHEAQKLLLRDGTLANFTIQSPSTLPTITLGLPANSRTEGELSSLKVSRVPVVTAGGSSVFLPLSREDQAGQMNPHLPVIILEPSGLVRTPLLTVQGLDSVPLQFAQPLDHLSAGGAQSHKPLSRARSEPLPQSPHALHTHLLQQQHNTQLLERLKQQTHLGKLMSKSSEKPRLHQIPSEDMDSEDGGGTSPTEPAYHSRGRSESLREVEPSASKTQEEQMNLQHALILNQSLLWEQQKQLQQLHRQMETLAVPVLRGGGGAVGGLGVHRPVFRTQSSPASTSLTLPEKTLSLPAQDTSSKPRFTTGLVYDSQMLKHQCTCGDNSSHPEHAGRIQSIWSRLQERGLKGQCESIRGRKATLEELQSVHTERHVLLYGTNPLNRLKLDNRKLAGILSQRMFVMLPCGGVGVDNDTIWNESHTSTASRLAAGSVVELAFRVAKGELKNGFAVVRPPGHHADPSNPMGFCYFNSVAIAAKQLQHKLSVSKILIVDWDVHHGNGTEEVFYNDPSVLYISLHRYDDGNFFPGSGSPAEVGSGAGEGFNVNVAWTGGLDPPMGDAEYLAAFRSVVMPIAQEFSPDVVLVSAGFDAAEGNPAPLGGYKVSAKCFGFLTRQLMSLAGGRLVLALEGGHDLTAICDASEACVSSLLGIQEPLPEDVLLQKPNANAVRSLQTVIQIQSQYWQSVKAYSGSVGLSYMAAQSRDCEETDAVKALASLSVGVLSSKSLPDEPMEHDSDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D5L8</accession>
    <name>A0A3P9D5L8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Collagen, type XII, alpha 1b</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D5L8"/>
    <dbReference type="Ensembl" id="ENSMZET00005030803.1">
        <property type="protein sequence ID" value="ENSMZEP00005029863.1"/>
        <property type="gene ID" value="ENSMZEG00005022277.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154923"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01482">
        <property type="entry name" value="vWA_collagen_alphaI-XII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000234">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000001">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF17">
        <property type="entry name" value="COLLAGEN ALPHA-1(XII) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="116"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="307"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52581" checksum="80BDB531250CC509" modified="2019-02-13" version="1">SVYKEQVMSVYLSDTFKNRKSSKQVTWTPALGKLLNYRLKYVPHNGGKEVVQKIPAKATCTIMKNLKPATTYNITVLPIYKRSEGKAKQGVGTTRIVGVVSSLVLDTQCKTTAKADIMLLVDGSWSIGRKNFKTIRNFIARLVSVFDIGPDRVQIGLAQYSGDPKTEWHLNTHHTKESLLNAVANLPYKGGNTMTGMALNHILQYNFKPNVGLRPDSHKISILITDGKSQDEVIVISQNLRDSGIELYAIGVKNADEYELRSIASDPDDIHMYNVYDFQFLVDITDELSVNLCNSVKGSGREGAISAPTNLVTSEVTQSSFRATWTPPNGTVEKYDVTYMMTAGEHGGTVFNGSVSTVVLENLNPLTEYVISVYAVVGKQSSEPLRGTETTRECFLFCFSAAGCMDIPPPAGEVVVGGDRPPNLGGPEVSPERWRLIPNLTYRHRHTGTHRHKHPFPPSCSHMHSLHTQPTWRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6W7</accession>
    <name>A0A3P9D6W7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">trypsin</fullName>
            <ecNumber evidence="8">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_004560427.1">
        <property type="nucleotide sequence ID" value="XM_004560370.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6W7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029907"/>
    <dbReference type="Ensembl" id="ENSMZET00005030848.1">
        <property type="protein sequence ID" value="ENSMZEP00005029907.1"/>
        <property type="gene ID" value="ENSMZEG00005022312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471893"/>
    <dbReference type="KEGG" id="mze:101471893"/>
    <dbReference type="GeneTree" id="ENSGT01050000244971"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF58">
        <property type="entry name" value="SI:DKEY-33M11.8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018228003" description="trypsin" evidence="10">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="27"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="252" mass="28210" checksum="0AF242855BA82CDF" modified="2019-02-13" version="1">MAAVAITTVLLLLSFSVNSQKENTGRIIGGQEVEPYSIKYQASLQTEVGDHYCGATLVHPEWVVSAAHCWRPSNFMRVVLCEHSLIKTEGFEQIFNVSKIYVHNYNFRTYENDIMLIKLSRPAQLNAYVQPVLIPDEGTPPFSGTCIVSGWGVTQVYSYTLSPVLRAVDVREIPYCTWYYWGRIKPGMLCAGSPYGGKDSCQGDSGGPLVCNGYFEGIVSWGIGCGNKYYPGVYTRVRSYIQWINWVIDNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D845</accession>
    <name>A0A3P9D845_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Bromodomain containing 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004556341.1">
        <property type="nucleotide sequence ID" value="XM_004556284.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D845"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030292"/>
    <dbReference type="Ensembl" id="ENSMZET00005031245.1">
        <property type="protein sequence ID" value="ENSMZEP00005030292.1"/>
        <property type="gene ID" value="ENSMZEG00005022580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482734"/>
    <dbReference type="KEGG" id="mze:101482734"/>
    <dbReference type="GeneTree" id="ENSGT00940000157236"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15572">
        <property type="entry name" value="PHD_BRPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000008">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF17">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="269"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="578"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="14">
        <location>
            <begin position="1046"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="753"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="514"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1176" mass="133293" checksum="184DEB1FED2DBB53" modified="2019-02-13" version="1">MKKKSRNQRPAVIKRETSPIKPSPNRETLTYAQAQRMVELEVDGRVHRLSIYDKLDVITDDDPTAQEIMECNSNKENNEKPQQVLVRSVRLKNNQQKKNAALTTSHGGSATHSSASGLLEPKVRTVEYNLPVVPKRPATYYKYTERTPEELDEEVEYDMDEEDYAWMEIINEKRKSEGISQVSHNLFEFLMDRFEKESFLATQGQSDLQSLVDEDAVCCICMDGDGADSNVILFCDSCNIAVHQECYGVPYIPEGQWLCRHCLQCPTRPAECVFCPNRGGALKKTDDDRWGHVACALWVPEVGFSDTVFIEPIDGVRNIPPARWKLTCYLCKEKGVGACIQCDKINCYTAFHVSCAQKAGLCMKMEPVKEVTASGATTFSVKKTAYCCSHTPEGCDRRPLNIYEEPHPKNGAFHKRAEKKGKAKGWQKKKNKRADPEPETEPETPTSSGPSITASSFDTILNQVSVQRKRSFVEGVLSYWVLKRQSRNNVPLIRRLQANPQPPKAKKTDHMESNQALKEQLKEWHRLRHDLERARLLLELIRKREKLKREEMKLQQSVLEVQLTPFNILLRAVLSQLQEKDQYSIFAQPVSIKEVPDYLDIIKNPIDFSTMRKRIDAHFYRSLEEFEADFDLIISNCMTYNSKDTFFYKAAQRMQDHGGAILRRARREAERIGFDFPSGLHLPEVPKLQPTPPFTWEDVDRLLTPTYRQKTPLEDQLKELLEKLDLSIAMKHSPSRSKRLKLLKKTITEVRSEISLKNSLPPQPSTPDPSPSPAESEDQPLRELLADPSIPQEDKSLPPPPLETLTLPSQILPMDLDPTPVKLTKPLDQSPTEFEDVTNTSTSVPSDTPNGHIPESLLPKSDLYVERYNRRTNVLFRKSKSASPQKLPRTQEVSSGSPPPLGAKTFLSVVIPRLETLLLPKKRKRSSSADGEDDEESPIKRLGTGMANGFVVEEEGVVSQSPRLLEPRRRCASESSISSSGSILCDTRTVILSKSGKGRPATARRSTVDDKSTLMTCIENGEFIKAAKISSEVWKPTAASPFVLEPLKLVWAKCSGYPSFPALIMDPRSRRTMCRHSGVELPQPPLDVLRAGERMQFRSAEKLFLVHFFDSRRSWQWLPKSKMAPFGVNKMLDRMKLMEARSSSVRKSVRLAFDRAMNHLDRARELKPNTGLGVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9M1</accession>
    <name>A0A3P9D9M1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29990"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>K(+)(in) + L-glutamate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-glutamate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9M1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031054"/>
    <dbReference type="Ensembl" id="ENSMZET00005032056.1">
        <property type="protein sequence ID" value="ENSMZEP00005031054.1"/>
        <property type="gene ID" value="ENSMZEG00005023153.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155464"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070779">
        <property type="term" value="P:D-aspartate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140009">
        <property type="term" value="P:L-aspartate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098712">
        <property type="term" value="P:L-glutamate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF24">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00713">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 17" id="KW-0769">Symport</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="434" mass="47838" checksum="2ABDE83C19934487" modified="2019-02-13" version="1">MTISNSEPDTMDSAYRMQRIRESIHIRTMKAKRKVEEISKEDVQAFLKKNSFVLFTVGAVIVGIVLGFALRPYKMTYREVKYFSFPGELLMRMLQMLVLPLLISSLITGMAALDSKASGKMGMRAVIYYMTTTIIAVFIGIIIVLIIHPGKGSKDEFGKQQTIEQVSPADAFLDLIRYAPIGILFLIAGKIVEMDDLTQMGGQLGMYTITVIIGLMIHAVLILPTLYFVITRQNPFIFIAGLLQALVTALGTSSSSATLPVTFKCLEENNRIDKRITRFVLPVGATINMDGTALYEALAAIFIAQVNNMEMNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSIGAGIVEFLSRHELRSKDVEMGNSVLEEKERKKPYKLISQDSDFENDKRGHSESNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9Y8</accession>
    <name>A0A3P9D9Y8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Speckle type BTB/POZ protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552475.1">
        <property type="nucleotide sequence ID" value="XM_004552418.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004552476.1">
        <property type="nucleotide sequence ID" value="XM_004552419.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004552477.1">
        <property type="nucleotide sequence ID" value="XM_004552420.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774819.1">
        <property type="nucleotide sequence ID" value="XM_012919365.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9Y8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030946"/>
    <dbReference type="Ensembl" id="ENSMZET00005031938.1">
        <property type="protein sequence ID" value="ENSMZEP00005030946.1"/>
        <property type="gene ID" value="ENSMZEG00005023062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487846"/>
    <dbReference type="KEGG" id="mze:101487846"/>
    <dbReference type="CTD" id="8405"/>
    <dbReference type="GeneTree" id="ENSGT00940000154376"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18518">
        <property type="entry name" value="BACK_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18279">
        <property type="entry name" value="BTB_POZ_SPOP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03774">
        <property type="entry name" value="MATH_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034089">
        <property type="entry name" value="SPOP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="377" mass="42459" checksum="77DAC5A8B3E0EC5E" modified="2019-02-13" version="1">MLAMSRVPSPPPPAEMSSSPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVRVPDCRLAEELGDLWASSRFTDCSLCVAGQKFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPDVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCTNLSVENAAEILILADLHSADQLKTQAVDFINYHAADVMETSGWKSMVISHPHLVAEAYHSLASAQCPFLGPPRKRLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAH5</accession>
    <name>A0A3P9DAH5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized LOC101463575</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
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                <person name="Tan F.J."/>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004564405.1">
        <property type="nucleotide sequence ID" value="XM_004564348.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAH5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031705"/>
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        <property type="protein sequence ID" value="ENSMZEP00005031705.1"/>
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        <property type="component" value="LG6"/>
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        <property type="term" value="F:ciliary neurotrophic factor receptor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:ciliary neurotrophic factor-mediated signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="4_helix_cytokine-like_core"/>
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        <property type="entry name" value="Ciliary_neurotrophic_fac_CNTF"/>
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        <property type="entry name" value="CILIARY NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CILIARY NEUROTROPHIC FACTOR"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="200" mass="22401" checksum="94628581207A097F" modified="2019-02-13" version="1">MAGRSTRGINGSNGSRTAPARAAALADLLHYECSTLLELFRKKENFTEDVTDRRLVSVPPPSSQLDTRDKLWRIHSALLQCQKLLEKAVAKEEEELGGGKKGKYENKRKLVKERLPLLILSTGELLKAAEGTTSLTPSVEGLEVNVPTGLLDLKLWVYRVYKEVNYWSKTAANTLKELPSVIVKEGARTTRARNRRSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAU9</accession>
    <name>A0A3P9DAU9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 1, regulatory subunit 3B</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAU9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031266"/>
    <dbReference type="Ensembl" id="ENSMZET00005032277.1">
        <property type="protein sequence ID" value="ENSMZEP00005031266.1"/>
        <property type="gene ID" value="ENSMZEG00005023310.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159475"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM21_dom"/>
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        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF13">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="1">
        <location>
            <begin position="136"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="296" mass="34377" checksum="79BFCF34E881CE35" modified="2019-02-13" version="1">SSTPLKLQHFYKPILVYLFHSTIRFCPCHSPPCFFHHLHMKTKALRMRLLPIFYRNISFSYRCQTKNGTKTKKRVTFADHKGLALTRVKMFSPFSDPIDIPMNIQEQLSSALSLKAEDDRLVLGFAQPASDYLLFRQRLEENLICLEHCLLKEKAFAGTVKVRNVSFEKSVKVRVTFDSWKSHTDVDCVYMKDSYPSLHHDTFSFEVSVSGELKPHERIEFAVCYQVDGCEHWDSNQGNNYSITWSSMRRGHQQAWSRPSCDYGVHFDRYGSPTCSHGIFPDWPGYAGYENIGPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DB80</accession>
    <name>A0A3P9DB80_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat domain-containing protein SOWAHB</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SOWAH family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DB80"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031391"/>
    <dbReference type="Ensembl" id="ENSMZET00005032406.1">
        <property type="protein sequence ID" value="ENSMZEP00005031391.1"/>
        <property type="gene ID" value="ENSMZEG00005023397.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183003"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058889">
        <property type="entry name" value="WHD_SOWAHA-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN SOWAHB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25877">
        <property type="entry name" value="WHD_SOWAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SOWAHA-C winged helix-turn-helix" evidence="6">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="366" mass="41247" checksum="4693F29F22A87AC1" modified="2019-02-13" version="1">MSDVSEESLLDYFYSAGGDSGRVKNADILRTFKPFIGHSDLQLRAKYREEFKLIIDRIAVVKSENGEKYLILKKKYRNLVQEREAKHLRPDGDRQRHLSPARTTTTSVQWEVTDAPTSTHHEKEEQDVPMSCGEADATAEVNLKSAHYSLLIVKRKGADPVHHSPRPPPAIQIHEAPEQSNAEDELDRDSGSKVTLDPLEKEWIYSAAGARVPDLSQLLRQDRALANKKVTALHWAAKHGNEEMATLVVNAGGDVNIKSVSGYTPLHIAALHGHRHILDLLVGTYGAKENLRDYSGHLACHYLNIKEAEEFQVTQARERNKNRKLASLFHSKKKWGSAEELAPIEEERTASHQLALPAFRPRKFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEY5</accession>
    <name>A0A3P9DEY5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Deoxyribonuclease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Zymogen granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the DNase I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014262690.2">
        <property type="nucleotide sequence ID" value="XM_014407204.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024655885.1">
        <property type="nucleotide sequence ID" value="XM_024800117.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024656927.1">
        <property type="nucleotide sequence ID" value="XM_024801159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DEY5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033238"/>
    <dbReference type="Ensembl" id="ENSMZET00005034362.1">
        <property type="protein sequence ID" value="ENSMZEP00005033238.1"/>
        <property type="gene ID" value="ENSMZEG00005024807.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005034379.1">
        <property type="protein sequence ID" value="ENSMZEP00005033255.1"/>
        <property type="gene ID" value="ENSMZEG00005024815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477007"/>
    <dbReference type="GeneID" id="112431505"/>
    <dbReference type="GeneTree" id="ENSGT00950000182846"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042588">
        <property type="term" value="C:zymogen granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10282">
        <property type="entry name" value="DNase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000035">
        <property type="entry name" value="Deoxyribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018057">
        <property type="entry name" value="Deoxyribonuclease-1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016202">
        <property type="entry name" value="DNase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033125">
        <property type="entry name" value="DNASE_I_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371">
        <property type="entry name" value="DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371:SF29">
        <property type="entry name" value="DEOXYRIBONUCLEASE-1-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000988">
        <property type="entry name" value="DNase_I_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00130">
        <property type="entry name" value="DNASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00476">
        <property type="entry name" value="DNaseIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00919">
        <property type="entry name" value="DNASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00918">
        <property type="entry name" value="DNASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044597220" description="Deoxyribonuclease" evidence="20">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="21">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Essential for enzymatic activity" evidence="19">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000988-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000988-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="278" mass="31344" checksum="9619782BB12E884F" modified="2019-02-13" version="1">MHLVGTLGLFLTLLHLSNSLLLGAFNIKSFGDTKASNTTLMNIITKIVQRYDVILIQEVRDSDLSATQKLMEYVNKDSPQYKYIVSEPLGASTYKERYLFLYREALVSVAKSYTYDDGPEETGQDAFSREPFVVMFSSKHTAVRDFTLIPQHTSPESAVRELNALYDVVADVRARWNNDDIVLLGDFNAGCSYVSGSDWQQIRIFTDKTFHWLITDAADTTVSQTVCPYDRIVVTADMMRGVVKESAKVYNYMTDLNLKQDLALAVSDHFPVEVKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFN0</accession>
    <name>A0A3P9DFN0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFN0"/>
    <dbReference type="Ensembl" id="ENSMZET00005034409.1">
        <property type="protein sequence ID" value="ENSMZEP00005033283.1"/>
        <property type="gene ID" value="ENSMZEG00005024842.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286915"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16040">
        <property type="entry name" value="SPRY_PRY_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029495">
        <property type="entry name" value="NACHT-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14484">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01288">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="58"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="781"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="109847" checksum="9D4C11D841F4721C" modified="2025-10-08" version="2">MNQIYTELYITEGGTAEVNDKHEVRQIETASRKSDRPETTIRQENIFKASPGRDEPIRTVLTKGVAGIGKTVLTQKYTLDWAEDKANQDIQFIFPFTFRELNVLKEEKFSLVELVHHFFTETKEAGICSFEDFQVVFIFDGLDECRLPLDFHKTKILTDPRKCTSVDVLLINLIRGKLLPSTRLWITTRPAAANQIPHKYVGMVTEVRGFTDPQKEEYFRKRFRDEEQASRIISHIKTSRSLHIMCHIPVFCWITATVLEDELKTKEGGQLPKTLTEMYIHFLVVQAKVKKVKYDGGAETDPHWSPESRKMMESLGKLAFDQLQKGNLIFYESDLTECGIDIRAASVYSGVFTQIFKEERGLYQDKVFCFIHLSVQEFLAALHVHLTFINSGLHLLEEQQTTSDESEIEEYAETDLYMTAVDKALQSPNGHLDLFLRFLLGLSLQTNQTLLRGLLIQTGKSSQTNQETVQYIKKKLSENLSAEKSINLFHCLNELNDRSLVEEIQQSLRSGSLSTDKLSPAQWSALVFILLSSEKDLDVFDLKKYSASEEALLRLLPVVKASNKALLSSCSLSEKGCKDLLSVISSQSCSLRELDLSTKRLNDLAVKILSAAVQSPHAKLNILRSARFVFCFLLFVCFVFLLHPDYTLTTVFVHVFIFRLNVCELLEKNCEALSSMLSSQSSTLTELDLSIKNVQDSGVKLLSAGLQSLNCKLNSLRLSGCCLIAEKGCTSLASALSSNPSHLRELDLSYNHPGASGMKLLSAGLKDPGWRLDTLRYGENDHGSITAAGLCLFSPSDSCQLTIDTNTVDTELQLSDNNRKVTHVKKVQSYPDHPDRFDVCEQLLCRNGLTGRCYWEVEWRGRVDISVSYRSIRRKGHSDDCLFGWNDQSWSLWCYNGAPRSVLHNNRETSISSSSSSSVSNRAAVYVDCPAGTLSFYRVSSDTLIHLHTFNTTFTQTLYPGFRLWSPGASVTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DKQ2</accession>
    <name>A0A3P9DKQ2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DKQ2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034938"/>
    <dbReference type="Ensembl" id="ENSMZET00005036183.1">
        <property type="protein sequence ID" value="ENSMZEP00005034938.1"/>
        <property type="gene ID" value="ENSMZEG00005026121.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155961"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="332" mass="37948" checksum="D5B7A2C32569F764" modified="2019-02-13" version="1">MELTASHSIPLSDGNSIPLIGLGTYTPKGTAYESVKIAIETGYRHIDGALIYYNEHEVGQAIRDKITDGTVKREDIFYCGKVCKAYFLVRPTLEKTLTTLQLDYVDLYIIGLPMAFKVCTHFNVDYIVYYCAFLCLSQALEACKDAGLVKSLGVSNFNKRQLELILNNRKYKYSNLGNVECHPYFTQQNWLEYCRQNGIVIVGYSPLGTSRDPSWYDDLLVSIAKKYNKTTAQVCLRFNVQRGVVVIPRAQPCSHKENFEIFDFSLSDADMKATHRNWKQVDVIAHKRASGHLFTNRCRPSARQLQLIQLERHFSLKKPPHLCQFSHRLANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DKW1</accession>
    <name>A0A3P9DKW1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DKW1"/>
    <dbReference type="Ensembl" id="ENSMZET00005036046.1">
        <property type="protein sequence ID" value="ENSMZEP00005034806.1"/>
        <property type="gene ID" value="ENSMZEG00005026022.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244823"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001594">
        <property type="term" value="F:trace-amine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15055">
        <property type="entry name" value="7tmA_TAARs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000318">
        <property type="entry name" value="Trace amine associated receptor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF381">
        <property type="entry name" value="TRACE AMINE ASSOCIATED RECEPTOR 19P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="329" mass="36843" checksum="40062ED36108E0B3" modified="2019-02-13" version="1">MSKSQKVLSVHLDVAFSLGETFHHSSNFSLKMIKTVFLLPRANVLLTVNLIIFVSSCRQLHTPTNILLLSLAVSDFLVGLLLMPGEILRNTACWFLGDLTCSMYNYMSLIVTSTSVGDMVLISIDRYVAICDPLHYPTRITDRRVKLCVCLCWLCSVFYSSLFVKDDLTQPGKHNSCYGECTIDVDLITGTIDLLLTFFVPVTVIVVLYLRVFVVAVSQARAMRSHVTVAALQLSVTLTTKKSELKAARTLGVLVVVFLLCFCPYYCVTLARDDLLNSSSVSFLLYLFYFNSCLNPLIYALLYPWFRKAVKLIISLHILQPGSCEISIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DML0</accession>
    <name>A0A3P9DML0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004560490.1">
        <property type="nucleotide sequence ID" value="XM_004560433.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DML0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035437"/>
    <dbReference type="Ensembl" id="ENSMZET00005036688.1">
        <property type="protein sequence ID" value="ENSMZEP00005035437.1"/>
        <property type="gene ID" value="ENSMZEG00005026479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487681"/>
    <dbReference type="KEGG" id="mze:101487681"/>
    <dbReference type="CTD" id="121355"/>
    <dbReference type="GeneTree" id="ENSGT00940000164745"/>
    <dbReference type="OrthoDB" id="10069248at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051591">
        <property type="entry name" value="UPF0224_FAM112_RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402:SF5">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="5">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CHHC U11-48K-type" evidence="5">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="196" mass="22141" checksum="B3E1FBAC1AE6B391" modified="2019-02-13" version="1">MSFERNGSLSCKFQLQMASNFVIGSTSSPCRTSSAEPAQLVEEYDGKGNTDPEKLLQCPFDKNHKIRSSRFPYHIIKCRKNHPKLARELKTCPFNARHLVPKHELAHHTETCEDRVPVDMEEDGSSSSNGPCNWHVPVSTWVNPNMTEDWDQEADNTAPPFVWGETKTIGPKQETRPTNNLGPTFRSPSDIPWSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DN49</accession>
    <name>A0A3P9DN49_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tuftelin</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_024654198.1">
        <property type="nucleotide sequence ID" value="XM_024798430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DN49"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035556"/>
    <dbReference type="Ensembl" id="ENSMZET00005036813.1">
        <property type="protein sequence ID" value="ENSMZEP00005035556.1"/>
        <property type="gene ID" value="ENSMZEG00005026566.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476708"/>
    <dbReference type="KEGG" id="mze:101476708"/>
    <dbReference type="CTD" id="100005886"/>
    <dbReference type="GeneTree" id="ENSGT00950000183065"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051375">
        <property type="entry name" value="Tuftelin_GRINL1A/MYZAP/CCD68"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171">
        <property type="entry name" value="GDOWN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23171:SF17">
        <property type="entry name" value="TUFTELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="416" mass="47492" checksum="57F22464F922B852" modified="2019-02-13" version="1">MGSFWKKIRQGAGHKMPWSRRSATKYLSDGGGINFSEMSGGVTRAVEKGEEDDETKDRCRQLRLSLQRRDQTGNTSQQHNSKESTIEFAPPQKPEGQEDEVEVRPHIEVEVIKFYLGKNPPEESVKMLTDEVSQIQEVRYCLKTLRQQMAARQNGNNNQRPANGFRVKAPTSQPGVINANGVHTDAYVGDNQEESARLREVTKRLYAQLKEMEKQHQEEIDILQAESNEYQAQLAEQTERLQKAEEQSAERGQQVEELQKLLGNMEIENGILKDKMAAGEAELLQLKAGGEEAGEKEQRCAELEKEVAVLKEKIHHLDDMLMSQQRKVRHMIEQLQNSRTVLQERDRAIRDLEEKVAFLEAENKEMHDHMEYYLAGQDLPPSSTENKPEVVYSKPLTPTTQSSKALPFIKVIEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ17</accession>
    <name>A0A3P9DQ17_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="11">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58433"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:43485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="13">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ17"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036231"/>
    <dbReference type="Ensembl" id="ENSMZET00005037505.1">
        <property type="protein sequence ID" value="ENSMZEP00005036231.1"/>
        <property type="gene ID" value="ENSMZEG00005027030.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159326"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120548">
        <property type="term" value="F:phosphatidylinositol phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000105">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF10">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 14" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 11 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="17">
        <location>
            <begin position="545"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="661"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="817"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1055"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="927"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="964"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1228" mass="137589" checksum="A1B840E68F274D89" modified="2019-02-13" version="1">MNKKRYFLDPPEIKDYLVKGERFTKWSEDSTKTVPVTMKMDPKGFFVYWINQSKETTFLDVATIRDTRTGKYAKLPKHPKVRNVFNLDFPDSNHLAKTLTIVSGPDTVNLTYHNFFASKEKVTQNWADDILAITYNAARNNACRQVFLDKIYVRLSLQTNKDGKIPVKHIYKMFPADKKRVESALAAAQLPKGKYDTIKPDVFTETAFRSFMTHLCPRPEIYEIFTSYSTKPTMTKENFTKFLNEKQRDSRLNEELFPRLRQDQIKALIDKYEPLSNNSNRGLISPEGLLFYLMGPETSVVMQDSLAKSQDMTQPIPHYFVKSSHNTYLTAGQFSGVSSPEMYRQCLLAGCRCLELDCWKGKPPDEEPIITHGFTMTTEILFKDVIEAIAESAFKTSQYPVILSFENHVDSVKQQEKMANYCKTIFGDALLTEPLDKYPLKPGQQIPSPSELLGKILIKNKKGSHEKPAQNKKTAAAAADQTAAAATNAQAPNVSLTLFLCVSPEPEATVEENEEQEDTEEQDEEKMKTSDEGTAGQEVTAYEAMSSIVNYIQPNKFISFENARKKNKSYAISSFVETKGEAMIAKSAVEFVEYNKRQMSRIYPKGTRMDSSNYNPQPFWNVGCQMVALNYQTMDFPMQLNMALFEFNGRTGYLLKHDVMRRNDKKFDPFCDRIDTVVASTLTIKIYSGQFLADKNVKTGVEVEVIGLPGDPKKKYRTKWSTTPNAINPVWNEEPFVFEKILLPELASLRIVVHEENGKFVGHRIIPLDAIQSGFHHICLRSESNMPLTLPALFVYIEVKDYIPAAFADFTDALFNPTKGTEKTTKPPKQSSSDYVSPYELPLGAQPPADQAKESEAPAAEKAASEPTPPADATDQSPPAAGAEEAKKEEESKAETPQILDEAPADAAPDTGSSRSETLPEASPSPEETKASPEPEAAPEAKEEPSTESCTNPEPTSDKKEEASAAAEPAEAPSAAAVPSPTVATTESAGSGDSSQPQTEPSTVTTEELTQHKSYQKVIKRQEKEIKELEKKYQKKGEDLIQKYSDSFKALKKKVSVKKKEGGDNTPESNGKTERVQELKEKMTSEIKTLFAEQYDQMKKKKEQCATERLAKLLEMAMEKHAIELKTLESVFHLQHVFCFVVLLQSSDYSPQQEALMKKQAATLEEIKTLTNQLNQEALKEHDQKTRSLAREVREAVNVCVGAHFPELVDEVDKSGGGVGFYGDVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQW0</accession>
    <name>A0A3P9DQW0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sprouty-related, EVH1 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQW0"/>
    <dbReference type="Ensembl" id="ENSMZET00005037943.1">
        <property type="protein sequence ID" value="ENSMZEP00005036658.1"/>
        <property type="gene ID" value="ENSMZEG00005027339.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156841"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10574">
        <property type="entry name" value="EVH1_SPRED-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000052">
        <property type="entry name" value="Sprouty-related, EVH1 domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023337">
        <property type="entry name" value="KBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041937">
        <property type="entry name" value="SPRE_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF11">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51488">
        <property type="entry name" value="KBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="KBD" evidence="10">
        <location>
            <begin position="216"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="462" mass="51367" checksum="B3C814C0C3761416" modified="2019-02-13" version="1">SFTPTHPPSLTSSLSFYVCRYLFIDSYIVRVKAVVMTRDDSSGGWLNQDGGALSRVGVCRLLPTELAPVLGSTSSQFFIRGERMRDNQVILDCPLRKDLVYTIATPTFHHWKVEDRRCGLSFQSPADARAFDRGVRKAIDDLAEGSTTSSTALQNEGELGDDDVFTNTTDSSSNSSQKLETSLQPLESSPLPQRHKCPLGFRHDPYRLSDHYYLDQPLSRIPRHVTFEDEEIVRINPREHRSWLTGYEDYRHTTVRDKFINMDDPEPNVHFDKTEAQKHDYTYPLAPALSPSDSDPSLGPLNSKGQNVSYRQQFPSVVSSQPRSLLPSSSSSTNGGKGQKDDRMERAQCEHCGEAFYLSSNRRGRCQDAPDPVRMCIRRVSCMWLADTMLYHCMSDPEGDYSDACSCDGGEGSGGGCLGTRWLALFGLSLVAPCLCLYPPLHACHQVGLACGCCGGRHKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DR43</accession>
    <name>A0A3P9DR43_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sine oculis homeobox homolog 1a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sine oculis homeobox homolog 1b</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570143.1">
        <property type="nucleotide sequence ID" value="XM_004570086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DR43"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036712"/>
    <dbReference type="Ensembl" id="ENSMZET00005037998.1">
        <property type="protein sequence ID" value="ENSMZEP00005036712.1"/>
        <property type="gene ID" value="ENSMZEG00005027370.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464766"/>
    <dbReference type="KEGG" id="mze:101464766"/>
    <dbReference type="CTD" id="83415"/>
    <dbReference type="GeneTree" id="ENSGT00940000158292"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048793">
        <property type="term" value="P:pronephros development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014857">
        <property type="term" value="P:regulation of skeletal muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000063">
        <property type="entry name" value="SIX homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="122"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="167"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="290" mass="32515" checksum="5F3AA0CCCF0FA5EB" modified="2019-02-13" version="1">MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSILREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENNENSNGNSHNPLTSSINGNKTILGSSDDDKTPSGTPDHTSPSPAQLLGANPGLPSLHGLAPPPGPSAIPVPSGPDSMHHHHSLHHDTILNPMSSNLVDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DU13</accession>
    <name>A0A3P9DU13_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DU13"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037737"/>
    <dbReference type="Ensembl" id="ENSMZET00005039056.1">
        <property type="protein sequence ID" value="ENSMZEP00005037737.1"/>
        <property type="gene ID" value="ENSMZEG00005028135.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017288"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="295"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="528"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="608" mass="68729" checksum="B48B1D462ADDA291" modified="2019-02-13" version="1">VASAASVFDDEDTFKILIATDIHLGYLEKDAIRGNDTYTTLDEILQCAKQNEVDFILLGGDLFHDNKPSRQCLHKCLTMLRKYCMGDSPVRFEILSDQKVNFNTTQFPWVNYQDENLNISIPVFSIHGNHDDPTGAEGLCALDLLSASGLVNHFGHSHSVEKIEISPILIQKGITKLALYGLGSIPDERLYRMFVNKQVSMLRPKEDQDGWFNLFTIHQNRSKHGPTNYIPEQFLDDFLDLVVWGHEHECLIKPTLNEQQLFYVSQPGSSVATSLSPGEATKKKIGLLRVKGRKMKLQEIPLKTVRQFFIEDVVLADHQDCFTPDTPHVTKKVEDYCFAKVTEMLDEAERERLGCRLTPEKPLIRLRVDYSGGFEAFNTSRFSQKFVDRVANPKDIIHFIRRREQKEIKDESSIDYGKLFKPTAVEGLRVEDLVKQYFEAAEQKVQLSLLTEQGMGKAIQEFVDKDEKEAIEELITYQLQKTQLHLQSRGVTTEQDIDAEVRLFRDSKKNTAEEEKDIQEAMNRAKAHRLERGDGDFADQDVSDVNMDSDEGSVPVAAPTRGRGRGSRGRGGRGRGRGATASEPKPAGRGRSQKSSTTSQSILQGRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DUJ5</accession>
    <name>A0A3P9DUJ5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Laminin, alpha 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DUJ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037947"/>
    <dbReference type="Ensembl" id="ENSMZET00005039346.1">
        <property type="protein sequence ID" value="ENSMZEP00005037947.1"/>
        <property type="gene ID" value="ENSMZEG00005028372.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157124"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000106">
        <property type="entry name" value="Heparan sulfate proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000033">
        <property type="entry name" value="Laminin subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000209">
        <property type="entry name" value="Laminin subunit alpha 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000094">
        <property type="entry name" value="Laminin subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000188">
        <property type="entry name" value="Laminin subunit gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF444">
        <property type="entry name" value="BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="12">
        <location>
            <begin position="336"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="11">
        <location>
            <begin position="564"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="79180" checksum="D54BF7EF2A78E4F6" modified="2019-02-13" version="1">CMQCECNDHAAECDINGVCVGCTHNTTGPHCDQCLLGFYGDATEGTTDDCQLCPCPLTKPSNRFSPTCVLDASGQVLCDQSDQPNDKLITQHNTWVCVFRCASGFYGNPQVVECGCDVNGALSSQCNVTTGQCICRENVTGRTCDHCKSGFYGLQSGHGCMPCGCNKSGSLFESCDKEGQCQCVEGVTGHKCDRCSRGYYGFHDKGCIACGCDMAGTEETFCNATLGCVPAKTLEIVCARSHQISDGPSQKLNMWADFPSSVASSAALLPFVLYVCVFFQPGVSGRRCEECVSGWFGLSAENLDGCLQCFCSGLSQDCEEQGGLTRVYLAYSSTLPFLSLVSQSNLQGTVSGVYRQGSEMLLDTRQLNTSGLTGPLYWRLPAQFEGNQLLSYGGLLSYTVTFHAEDGSGLSNQEPQVLMRGGTLRKLAIYTDMVAPSNGVTTQHDIRLTEHKWKYFNSVSQRSVSHADFMSVLSNIEYIIIKASYGTRLQQSRYLISNITMEMAVEVEKSEVGNVARLIESCVCPPGYTGLSCQDCDVGYFRQPQSELSPQSKKSMFVRPCVRCRCNNHSEKCDAETGQCQDCKHHTSGQSCEKCASGYYGSVKGSIGDCSPCACPLLNNSFSPTCILEGAAGDFRCTACQPGYEGRYCERCSVGYYGNPSVPGGVCSQCSCSAWGSLHLLCDVLTGECECKDGVKGQSCNECEKRSIFQEGECVCDDTNTILILVFIRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARV1</accession>
    <name>A0A3P9ARV1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar MIF4G domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SGD1 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in targeting PPP1CA to the nucleolus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546881.1">
        <property type="nucleotide sequence ID" value="XM_004546824.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARV1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000440"/>
    <dbReference type="Ensembl" id="ENSMZET00005000501.1">
        <property type="protein sequence ID" value="ENSMZEP00005000440.1"/>
        <property type="gene ID" value="ENSMZEG00005000384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469351"/>
    <dbReference type="KEGG" id="mze:101469351"/>
    <dbReference type="CTD" id="64434"/>
    <dbReference type="GeneTree" id="ENSGT00940000153458"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000032">
        <property type="entry name" value="Nucleolar MIF4G domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="9">
        <location>
            <begin position="630"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="837" mass="95058" checksum="07525AE74EDCCA5A" modified="2019-02-13" version="1">MKGNWKHKGKTKNKKKGNAVLQKYREAVDVFLKSKGGSEEAESDQRLRFVKKKSRKELRKEKRKMKKAKMKSHYEGKNTVSLPPSDEGNPKKGADKHQQPHTQKKKMEKTKKEGSKSHPSEPKDKSDKSETPPPSKKGKQVNKLQETRKLALMEANEQEDREIKKLERCLGLNKRKNKKSLPQSFVADGLDYILGVLDSGSSAVGLYEDDDVDMETAKENFKKLDDSQGSGEDPESEGEMASEGSDDDIDDDGEDEDDDMSNEEEADEDEEMEDDQEGLNDSGGPDSEDEKEGETEEETDAPDTKTETVTSTSGKYLPPHLRNMGDDKRKAELEKLKRNVKGLMNRLSEPNMSSICGQLEELYMSSSRKDMNDTLTELLLAACVTPTLMPDRLLMEHILLVSILHHAVGLEVGAHFLETVVRKFDEHYKNPSGGKECDNLIAIVAHLYNFQVVHSVLIFDILKLLVGTFTEKDIELVLFVLRNVGFALRKDDPLALKELISEAQRKASDMGSKFQDQTRVRFMLETMMALKNNDMRKIPGYDPEPVERLRKLQRSLIHRSAGGSDMKLRVSLDSLLAAEQVGRWWIVGSSWSGAPMISKQEDTTTKQTPAQGQFSAKVLELARKQRMNTDVRRNIFCVLMTSEDYLDAFEKLLRMGLKDKQEREIVHVLMDCCLQEKNFNAFYVILGEKFCSHDRRFQMTFQFSLWDKFRELPNLSSSTFNNLVQLVTCFLQRKCLSLSILKVIEFGELDKPTVRFLRQVLTKLLKETEPEELASIFGRISGIPKLGMLREGLKLFIDHFLLKSILSQGAPEKAALLSERAQLATKAMEAKETKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AS27</accession>
    <name>A0A3P9AS27_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TERF1-interacting nuclear factor 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AS27"/>
    <dbReference type="Ensembl" id="ENSMZET00005000478.1">
        <property type="protein sequence ID" value="ENSMZEP00005000418.1"/>
        <property type="gene ID" value="ENSMZEG00005000397.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000248721"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7153" checksum="21352229DBAD0E7A" modified="2019-02-13" version="1">SPTPAVPNPRASDRYVSRLSRDLEHFERVIGFLETTYRLLPRLIPAIKHMKIMFGLKTMVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASL1</accession>
    <name>A0A3P9ASL1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane protein 93</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557474.1">
        <property type="nucleotide sequence ID" value="XM_004557417.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASL1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000367"/>
    <dbReference type="Ensembl" id="ENSMZET00005000426.1">
        <property type="protein sequence ID" value="ENSMZEP00005000367.1"/>
        <property type="gene ID" value="ENSMZEG00005000375.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470929"/>
    <dbReference type="KEGG" id="mze:101470929"/>
    <dbReference type="CTD" id="83460"/>
    <dbReference type="GeneTree" id="ENSGT00390000003917"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="110" mass="12104" checksum="05140F8D2655EB84" modified="2019-02-13" version="1">MAGVGAKREGPQFISEVAVRGNAAVLDYCRTSVSALSGATAGILGLTGLYGFIFYFLSSFLLSLLLILKAGRRWNKFFKSRRLLFTGGLVGGLFTYVLFWTFLYGMVHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATF1</accession>
    <name>A0A3P9ATF1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Syntaxin-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATF1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001000"/>
    <dbReference type="Ensembl" id="ENSMZET00005001077.1">
        <property type="protein sequence ID" value="ENSMZEP00005001000.1"/>
        <property type="gene ID" value="ENSMZEG00005000834.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234627"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:SNAP receptor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:exocytic insertion of neurotransmitter receptor to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Syntaxin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF34">
        <property type="entry name" value="SYNTAXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="189"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="281" mass="31703" checksum="823F021AC3E7B37E" modified="2019-02-13" version="1">MKDRLAQLKEKSDAGGDDIEVPVESEAFMDDFFAQIEDIRSSIDKIDESVTEIKKLYSTILSAPTSDQKTQDDVEALTNEIKKSANNARNKLKSIERQLESNADERASADLRIRKSQHAILAKKFVEVMTKYNEAQVDFRDKSKGRIARQLEITGKTTTDEELDEMLEGGNSAVFTAGIMDSKINQQALNEIEARHKDIMRLESSIKELHDMFVDIAMLVENQGGMIDRIESNMDQSVGFVERAVADTKKAAKYQQEARRVSAERREGLWQCVSALGQCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATL1</accession>
    <name>A0A3P9ATL1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TRAF-type zinc finger domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544702.2">
        <property type="nucleotide sequence ID" value="XM_004544645.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012772820.2">
        <property type="nucleotide sequence ID" value="XM_012917366.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012772821.2">
        <property type="nucleotide sequence ID" value="XM_012917367.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012772822.2">
        <property type="nucleotide sequence ID" value="XM_012917368.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATL1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000742"/>
    <dbReference type="Ensembl" id="ENSMZET00005000815.1">
        <property type="protein sequence ID" value="ENSMZEP00005000742.1"/>
        <property type="gene ID" value="ENSMZEG00005000674.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101481123"/>
    <dbReference type="CTD" id="10906"/>
    <dbReference type="GeneTree" id="ENSGT00530000063869"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051986">
        <property type="entry name" value="Innate_Immune_Apopt_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049439">
        <property type="entry name" value="TRAFD1-XIAF1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16295:SF19">
        <property type="entry name" value="TRAF-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16295">
        <property type="entry name" value="TRAF-TYPE ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21366">
        <property type="entry name" value="TRAFD1-XIAF1_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="565" mass="63030" checksum="10009057C40938A7" modified="2019-02-13" version="1">MADENTQFCGNCKHDIPEANFTTHEIHCRRNISLCDVCQEPVPRSDLQDHKQQEHTQITCKCGLKIEKNNLDAHQSSECSQRLVPCQYCELELVFSQSKDHEDYCGTRTEPCPYCKCNVMLREQATHPALCGSLTPPQERNNSRMGRSPGDPQSGAWLEAHSIRNPLRSQERGPKNNNVSAAEQQVFPRPSVYNTSRGFRPLGDWRNISPQNPFSSLLGQSDFLHSRSGSTWAHTEHTLDDDSSGLDYMLALSLQTEGDTGARGVEGNVWSGIWDHKIGKSNTSLSNNNYPDFTVESSTSAVQDHDQKDAMLPCEFCEELFPEDDLILHQTGCSPASAFASFSKQPSSPPKDDRTSSSTSGLMHSLPDTLASNIPTFPRSVSPASYSPPASPLEGDVVIPCEFCGVALEEAVVFHHQDKCDMRPQSAHPLNNVTKASIKKPLSPGREAFGLPSPEFQRRIRHQADFLDEDFAFDRETPSGQNQRGWQKSCIGQPNQRKASNFDVSLKNRPQQGGEEEGTHFSFCDTDKNASLKGLHYPENKEGRGNRRNQVSKLPKKQNEEQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATR8</accession>
    <name>A0A3P9ATR8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATR8"/>
    <dbReference type="Ensembl" id="ENSMZET00005001153.1">
        <property type="protein sequence ID" value="ENSMZEP00005001066.1"/>
        <property type="gene ID" value="ENSMZEG00005000919.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183089"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000075">
        <property type="entry name" value="Histone H1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="6">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="125" mass="12903" checksum="BA4A2622E6E77931" modified="2019-02-13" version="1">GVQIVLDSRPILCCCHWSSSVGELIVKAVAASKERNGLSVAALKKALAAGGYDVDKNKARVKTAIKSLVAKGTLVQTKGTRTSGSFKMNKATESKAKKPAAAKAKKPAAAAKKSPKKAATCIRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AW18</accession>
    <name>A0A3P9AW18_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G protein-coupled receptor 156</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551438.1">
        <property type="nucleotide sequence ID" value="XM_004551381.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AW18"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001905"/>
    <dbReference type="Ensembl" id="ENSMZET00005002000.1">
        <property type="protein sequence ID" value="ENSMZEP00005001905.1"/>
        <property type="gene ID" value="ENSMZEG00005001501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464311"/>
    <dbReference type="KEGG" id="mze:101464311"/>
    <dbReference type="CTD" id="165829"/>
    <dbReference type="GeneTree" id="ENSGT00940000159755"/>
    <dbReference type="OrthoDB" id="411630at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035677">
        <property type="term" value="P:posterior lateral line neuromast hair cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15292">
        <property type="entry name" value="7tmC_GPR156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041946">
        <property type="entry name" value="GPR156_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="61"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="579"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="814" mass="89574" checksum="656FF9B3FAA62D1E" modified="2019-02-13" version="1">MVDGLVPIMEPELNCSSQCESPFCFIQSGVSRQDSLDVLQRLCSLSTMAAELPRRSLSSVLIAVVWTLLSCGILLAFCFLLFTLRFKNNRIVKMSSPNLNALTLCGSVLTYSSGFLFAVEESGASIAVLQTRMWMLCVGSTLVFGPILGKTWRLYRVFTQRVPDKRVIIRDIQLMGMVALLILVDMLILTAWNLTDPIRCSRSVGAVVKVMERDVSYSLSQLVSCSSLYSNLWIIIVAVQKGCLLLYGTYLAGLTSNVSHPPVNQSPTIITCVTLVTCSSAVATPVSIFLQTWPNVVYSTVAGAIFICTLATNCMLFVPQLTQWRQFEEDQNNPSQMAKYFSSPSKSQPSVYSQDEIFYLLGENSSMKKLLNEKNAVIDSLQEQVNNAKDKLLRLMSASQHPEDQDMDSSATNLNSSSTQTTELQSEGPSTCSQSQKDTKSTLSPSALSPHLTAAHGSLSAVTPSSAPSSISNYSAPISVSSPLPTKIPACETQNNASALKRDASLPFMGLLRTPEETVQFVTSLQYRRGLNPSMAETFGSYSGLNLQVGPNTKPAGFVSSEQLQEILQELSVDAITETTLRSPDQAPRIPSQQKLTRDSTLSPLSPRTPCSLPSPALFRYPSISPYTMRKRRRPFHSSRGGLAPPCFYTGSEVPGCARARDTCALPSPEDITVDDNCISHHNSDLEEGKEEDTKVREVVRTCQRCVSRLPRCSVVHCEEQNRKAPEDVGAGGDNEQHRRHIRDSCGYSDSDSSSSTDYCYYHRPYCDSCLQRGSLLYSDSSSDSSDSEYDDYLSLYRSPRPVVFKEDLKPTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWL8</accession>
    <name>A0A3P9AWL8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription factor IIIB 90 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">B-related factor 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1. Interacts with MAF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554750.1">
        <property type="nucleotide sequence ID" value="XM_004554693.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004554751.1">
        <property type="nucleotide sequence ID" value="XM_004554694.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWL8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002100"/>
    <dbReference type="Ensembl" id="ENSMZET00005002200.1">
        <property type="protein sequence ID" value="ENSMZEP00005002100.1"/>
        <property type="gene ID" value="ENSMZEG00005001620.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484253"/>
    <dbReference type="KEGG" id="mze:101484253"/>
    <dbReference type="GeneTree" id="ENSGT00390000010349"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030223">
        <property type="term" value="P:neutrophil differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000012">
        <property type="entry name" value="Putative transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.650:FF:000001">
        <property type="entry name" value="transcription factor IIIB 90 kDa subunit isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="18">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="695" mass="76901" checksum="F4BF8C3CA55444B8" modified="2019-02-13" version="1">MSSKVCKNCGSSDIDVDHARGDAVCMGCGSVLEDNIIVSEVEFVETGGGGSLAVGQFVSAEDGARHPSFGDGHFSGMGKASRAQTLQRAKQHINIVGNQLQMNQHHMDTALNFYKMALIKHLTRGRKASHVIAACIYMVCRTEGTPHMLLDLSDILQVNVYVLGRTFLVLARELCINAPAIDPCLYIPRFAQMLEFGDKTREVSMTALRLVQRMKRDWMHTGRRPSGLCGAALLVAARLHDFRRTVKEIVNIVKVCESTLRKRLTEFEDTPTSQLTIEEFMKVDLDQECDPPCYTAGLKKKKAQQLEIEIKKKMDDVEGEIQEYQEEIDAELESSRPKLRGVYAAYAKGDLENDDKNNILSMSSKLVDDEEPEDEDELRAVAKHFGKDLNELTLEALIKLEQKRPEDEEGNQEQEDDGDFPQRKAPSLAFLLGSMPSSATLGLSESISSCVTDEKENDGAADSGELDLSGINDSEIELYLLSDKEVKIKTALWMAENSTYLKEQKEKEAKIAKEKALGIYKERKPRGPNRKHAPIRANTADEAIEKMLEQKRISSKINYDVLKDLNVKPCASPARNAESPKKERPAAKLAGRNRRPAQTQLSLSTPLSTLGKRLQPFISGQPNKKLATEQIGSSNPLPLPVEAPASGVVVESGPVVYDDVPGDEEEDEEDETCVSALEMLGSNDYGCDGDYDDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXM2</accession>
    <name>A0A3P9AXM2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein 653</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">67 kDa zinc finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Zinc finger protein Zip67</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with NR5A1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562942.1">
        <property type="nucleotide sequence ID" value="XM_004562885.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXM2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002384"/>
    <dbReference type="Ensembl" id="ENSMZET00005002493.1">
        <property type="protein sequence ID" value="ENSMZEP00005002384.1"/>
        <property type="gene ID" value="ENSMZEG00005001900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465022"/>
    <dbReference type="KEGG" id="mze:101465022"/>
    <dbReference type="CTD" id="115950"/>
    <dbReference type="GeneTree" id="ENSGT00940000160257"/>
    <dbReference type="OrthoDB" id="8685330at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000183">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZFP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000651">
        <property type="entry name" value="Putative zinc finger protein 653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000685">
        <property type="entry name" value="Zinc finger protein 653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="535"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="652" mass="73485" checksum="DF4E0E7BF18C4B27" modified="2019-02-13" version="1">MAKMAHQLAEVEAPLDTNQAGEQGKGVLRRCRGRPRLTDSDRAQRRLESRKKYDVRRVYLGESHKLWSDLRRRTGLSDAGLAEYLILLNSTYGEKYQQKYCGKKIAPEVSAKQKRGRKQCVSSLQSLVCWYQQHSHSCPHEPQLRALETQSNFSTTAVWQCEGNHSFVQYLFSPLGEASDSEHEEGVNRDSDGECAVKTDVSVAKNIVSRKRRKEAHRQLKDVGLNVDVSEEHQEAVSQVEEVVVPTPEASVLASSKDAPLTGQPIWEVEMVRQQGSLTAAFHSVPTEEEEETEDLRQGKDGGEEERLTEEEVRTVRHDYECVMTASLADELDKSDEDLVLSQSLSGSVRLSAQTELSVPPTMQVQEQSELFEPQTLQTVVTGCEIPDQRTALEGSQLIIITGPSYEALASEGIQLNMGGGNVEEVTCTVIGGVTYNQVCTADSKIRTAEDEDSMTGMTDKQLLQPSVDTLELGSDRQLQRSLSRSKRSRRGPVIEADGMLKMFHCPYEGCSQVYVAISSFQNHVNLVHRKGRTKVCPHPGCGKKFYLSNHLHRHMIIHSGVRDFICETCGKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTPEAHYNFTCEFCDKRFEKLDSVKFHKLKSHPDKQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZX1</accession>
    <name>A0A3P9AZX1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PR/SET domain 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZX1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003218"/>
    <dbReference type="Ensembl" id="ENSMZET00005003347.1">
        <property type="protein sequence ID" value="ENSMZEP00005003218.1"/>
        <property type="gene ID" value="ENSMZEG00005002489.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159837"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057456">
        <property type="entry name" value="Znf_C17orf113"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF11">
        <property type="entry name" value="PR_SET DOMAIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25431">
        <property type="entry name" value="zf-C17orf113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="127"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1116" mass="126990" checksum="9364490C0D5F3569" modified="2019-02-13" version="1">MFEQYRYIENIPSSPQTSFRLVLRSQAHPVFSFFKFILKNAHFPLSFTPVTGTMPQRSSLRHTLVVQLKFLLFSLIIRKRFQEMSFFCEECQDYFQKECPSHGPPLFVRDTHAAPGTANRAALTVPSGLEVFSEGDEVDVRCVDAIYPKGALFGPYEGELVSKDRSSGFFSWIIVDVHNTYQSIDGSDETKANWMRYVRTSLEESDRNLTAFQHGKNIYFRVCRALAAGEKLRVWYSDDYIRRLHCVSQESIDRNLDTGEELKNGFLSGPGKDFKSPCLQSALQGKLSKQPSEESDGQPPAKRKKIDLIFKHVLEASLEDSGKFRFRSGQTSEYKVPALVSGFDSSESGFGVPNLKVEEKEEENQSTEKPSTSFCPNCVKLKRRILELEEELSRLRGEQGDPLTPTQVVLDEDEQDVDSADESIAADLVISPEDSSKLSSAGGRRIRRFKQEWLKKFWFLRYSPTLNEMWCHVCRQYTVQSSRTSAFIIGSKQFKIHTIKLHSQSNLHKKCLQLYKLRMHPEKTEEMCKNMMLLFNAAYHLALEGRPFSDLRSLAELLKKCELKVVDQYMNEGDCQILIHHIARAVKEDLAEKMRLSPFLSVIMDAQNDDLFSDMVAVYVQFVTNEGSPNTEFLSLQRLTMANVDGYLQVMDRAFGVLGLRFQDLLVVGLGVDGTNISSGMRANLYIAVQKTFPWILCLPIMIHRPHLEVLDAISGKELSCLEDLENNLKQLLSFYRYSPRMMAELRSTAPTLSEETEFLGDIRAIRWIIGEPNVLNALIKDYLEVVAHLKEISSQTQRADAAAIALTLLQFLMDYQSVKLIYFLLDIIAILSRLAFTFQGEYLLVSQVEAKIEEAIQEIGQLVDCPGEYLQEFEENFRESFNGVALKNLRVAESKFQSIREKICNRSQSILSQRLDLQSCSFAKACKVLDLSTWPSNHEDLQAYGDEEIKIIFNHLESIPTAAQEVSQTEARGSLVVEWKDLKADYYSMNGFKEVIGHICRYKQRFPLLNRIVQVVRVLPSSTACCDKGRGSLQKMCKNNRSRLTLEQMNDLLTVAVNGPPIANFDGKRALDSWFEEKSGSSYSLSAEVLNRMSAADQKCVLHSVDVNAEFYPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B109</accession>
    <name>A0A3P9B109_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-like protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004566119.1">
        <property type="nucleotide sequence ID" value="XM_004566062.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B109"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003402"/>
    <dbReference type="Ensembl" id="ENSMZET00005003534.1">
        <property type="protein sequence ID" value="ENSMZEP00005003402.1"/>
        <property type="gene ID" value="ENSMZEG00005002607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482371"/>
    <dbReference type="KEGG" id="mze:101482371"/>
    <dbReference type="CTD" id="285282"/>
    <dbReference type="GeneTree" id="ENSGT00390000007467"/>
    <dbReference type="OrthoDB" id="5914890at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04102">
        <property type="entry name" value="RabL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000525">
        <property type="entry name" value="rab-like protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="236" mass="26508" checksum="47B803356F0D585B" modified="2019-02-13" version="1">MCSAGSRVCRKLTRCFGGGVGKSSLVHLLCQNQVLGNPSWTVGCSVDVRVQDYKEGTPEEKTFYIELWDVGGSVGNASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEALNKDSSPTGVIISNGDYDREQFAENPVPLLLIGTKFDQIPENKRSEVLTRTAFLSEDFNAEEINLDCTNPRYLAAGTSNAVKLSRFFDKVIEKRYFTRDPSQMTGFTDRKRFNFKSLHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1W5</accession>
    <name>A0A3P9B1W5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 family 4 subfamily F member 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of aromatic C18 estrogens from C19 androgens.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>androst-4-ene-3,17-dione + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = estrone + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:38195"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16422"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>testosterone + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 17beta-estradiol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:38191"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17347"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B1W5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003905"/>
    <dbReference type="Ensembl" id="ENSMZET00005004066.1">
        <property type="protein sequence ID" value="ENSMZEP00005003905.1"/>
        <property type="gene ID" value="ENSMZEG00005002870.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155021"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000005">
        <property type="entry name" value="cytochrome P450 4F22 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF210">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4 SUBFAMILY F MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="6 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="549" mass="63392" checksum="4D2EC66D034E8EE3" modified="2019-02-13" version="1">LGLLDANFSLLMMTLLHTVLALVLSWTGLSSVLYIFSTGLFTVVALWTARLLLRHAWYTHKLSCFSKPQTRSWLLGHLGKMQSTEEGLQRVDDLVQTYKHSCCWFLGPFYHLVRLFHPDYVKPLLMAPVLIEHRKYRKELFLQTLFFLSGNSVLISNGEVWSRKRRLLTPAFHFDILKSYIAVFNSSAKTMHDKWCRLVAEGKTNLEMFDHVTLMTLDSLLKCAFSYDSNCQQSSSEYVSAIVELSDLIIERREKNILHHWDWIYWKTRQGERFKQALNTVHRFTRDVVEKRRTLLNQQRETEAQSEIAPTAQKRKDFVDILLLTKDEDGQGLTDEEMQAEANTFMFAGHDTTASAICWTLYNLARHEHYQEKCRQEVMDLIEGRDGQEIQWEDLSNLPFTTMCIKESLRLHSPVQAVTRSYTQDMVLPGNRTVPAGTICLVSIYGTHHNPTVWTNPHEYDPQRFDPSNKKSQTSHAFIPFSSGPRNCIGQKFAMVELRVVVALTLLRFRLTPGVNPELGSSRVRRLPQLVLRAEGGLWLQLEPLNTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2M8</accession>
    <name>A0A3P9B2M8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Urotensin 2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urotensin-2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2M8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004134"/>
    <dbReference type="Ensembl" id="ENSMZET00005004305.1">
        <property type="protein sequence ID" value="ENSMZEP00005004134.1"/>
        <property type="gene ID" value="ENSMZEG00005003190.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234774"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001483">
        <property type="entry name" value="Urotensin_II"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00984">
        <property type="entry name" value="UROTENSIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018093493" description="Urotensin 2B" evidence="6">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10049" checksum="8300F44CD52222D0" modified="2019-02-13" version="1">MDRVTAVSYCLGLLSLFLLLNVDGRSLFNPGECAKQHILFELECQMHATLRVLREDLELERKITANMVEGKSITRKRGEPCFWKYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3S5</accession>
    <name>A0A3P9B3S5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="5"/>
    <dbReference type="RefSeq" id="XP_014268634.1">
        <property type="nucleotide sequence ID" value="XM_014413148.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3S5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004541"/>
    <dbReference type="Ensembl" id="ENSMZET00005004743.1">
        <property type="protein sequence ID" value="ENSMZEP00005004541.1"/>
        <property type="gene ID" value="ENSMZEG00005003509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481161"/>
    <dbReference type="KEGG" id="mze:101481161"/>
    <dbReference type="CTD" id="4249"/>
    <dbReference type="GeneTree" id="ENSGT00940000153470"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070658">
        <property type="term" value="P:neuromast hair cell differentiation involved in neuromast regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027833">
        <property type="entry name" value="MGT5A-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15027">
        <property type="entry name" value="MGT5A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MGT5A-like N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="17">
        <location>
            <begin position="172"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF15027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="741" mass="84436" checksum="ADAE03C4864D4ECC" modified="2019-02-13" version="1">MATPFLWKLSSQKLGFFLVSFGFIWGMMLLHFTIQQRASHENSAVLRQQILDLSKRYIKALAEENQSVMDGPYVGTMTAYDLKKTLAVLLDNIMMRLGKLESKVENIYNGTGPNLSNGTSTITPSAPNSEKVNVADLLNGAQEKCELPPLDGFPHCEGKLKWMKEMWRSDGCYANYGVDGSTCSFFIYLSEVENWCPRLPWRAKTLNEEMDQRGQAEIRTSFEELYRMMSQREEFRWMMLRIKRMAEPWVSAIRSLAAKQNLGKRRKKKILVHLGLLTKESGFKIAENAFSGGPLGELVQWSDLITTLYLLGHNIRISASLNELKEIMRKVMGNKSSCPTQGDKVVELIYIDIVGLTQFKKTLGPSWVHYQCMLRVLDSFGTEPEFNHAHYAQSKGHKTPWGKWNLNPQQFNTMFPHTPDNSFLGFVVEQHLNASDIKHIDDVKRQNQSLVYGKVDNFWKDKKKYLDIIHSYMEVHGTVHGTSTVHLPGYVKNHGILSGRDLQFLLRETKLFVGLSFPYEGPAPLEAIANGCAFLNPKFNPSKSSKNTDFFKGKPTLRELTSQHPYAEVYIGRPHVWTVDIENSAEVERAIRSILSQKIEPYLPYEFTCEGMLQRVNAFIENQDFCHGQVMWPPLSALQVKLAEPGHSCKQVCQEEQLICEPSFFQHLNKDKDLARFGMDCQTVESSADTVVPAYSETRHHCIFQSDLLLFSCAGAHSTLQRICPCRDYMKGQVALCKDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3Y7</accession>
    <name>A0A3P9B3Y7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase, Mg2+/Mn2+ dependent, 1J</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004547645.1">
        <property type="nucleotide sequence ID" value="XM_004547588.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3Y7"/>
    <dbReference type="Ensembl" id="ENSMZET00005004820.1">
        <property type="protein sequence ID" value="ENSMZEP00005004615.1"/>
        <property type="gene ID" value="ENSMZEG00005003559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471645"/>
    <dbReference type="KEGG" id="mze:101471645"/>
    <dbReference type="CTD" id="333926"/>
    <dbReference type="GeneTree" id="ENSGT00940000166858"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF849">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="496" mass="54936" checksum="3626FF4596256680" modified="2019-02-13" version="1">MMISKVKNAMSNLVGGMMPHGHHHHNHHSGGQTCGTDSLPPRFPYGRPDFLDLTPELLQYSTEHASRPVLTLKRGSRLPWQTGYAEVINAGKSMLNEDQASCEKVFVKKPSGKHRNSTLLDQNGDGTGIPLHFWGVFDGHAGSGAAIMASKLLHHLIRDRLGEICHLLENPSSAPPICLAKNGSPYQAEAKKGGAQEPEDPDAVSDASVRFYMEKVVSLESLVMGVIETAFKQMDDLIEKEKSSYAISGGCCALAAIHLMGKLYVANAGDSRAIIIRNNEVIPMTNEFTPESERQRLQYLGFLRPELLGNEFTHIEFPRRIQHSELGKKMLYRDHSMTGWAYKTIVEDDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVYNSNIYIKPFLSCVPEVKVYNLDEHKHGPDDVLVMGTDGLWDVTTDKEVADAITAYLSCCDPSDPMRYTLAAQDLLMRSRGVLKERGWRLPNDRLGSGDDITVFVIPLAGHESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B406</accession>
    <name>A0A3P9B406_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucokinase regulator</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
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                <person name="Streelman J.T."/>
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            <taxon>Vertebrata</taxon>
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            <taxon>Ovalentaria</taxon>
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            <taxon>Cichliformes</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
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                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
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                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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            <authorList>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
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        <property type="match status" value="5"/>
    </dbReference>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="608" mass="65886" checksum="1834A2A13DF35727" modified="2019-02-13" version="1">MDGITYGRTLLLCTLLLWVFQVVSSGNVNVVVKPKVEVLKEENASLPCTVTPLTTGTIVEWYIDLGTRTRIAFCQGKEKKVDPGTPLTDRIKIGEDFTLTISSVKPSDELNFTCQVTDPAGSPDGTTSLKVFSAPEHPKLTTSQAITAGIPSSSEVGTCETKNGFPLPRIVWFRDAKPLPEVKDKQEKTYMVAKQVKETSGLITVTSSLYMQPMKEDKDSEFYCTVEYSMPGNKIETMDSNRIKINLNYPSDKIYFSLFNTSQPVKEGDTVTMKCETDGNPQPPFEFTKNGEEAQGKDGLLILKSVKRSDAAQYKCTALDFEIDFTLEKTIALTVDYIDPVKVTPAVSKVVMLGDKAAWQCRIKASRNHTVQWKKGSEVLSQNGTLSIQNVSYQNAGEYVCVGAVPSVPGLMSQASVNLTVKGKPVIDPPAPVKVGKEGDKVTLMCVAYGVPTPNFTWQPSGGEQSITVKGNKWVSTLTLKTTADMINGGVTCEVENEHGKDITVFPLSLEQVGSSAEVLLSGNPVLTSAGQGGSSAVVIAVVVCVLLLLLLVGLLYCLSKNNKLSCSKKDPKEVNSGMTNSSVVVELKTDKLNEEDGLLNKKNATEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5I2</accession>
    <name>A0A3P9B5I2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014264057.1">
        <property type="nucleotide sequence ID" value="XM_014408571.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014264058.1">
        <property type="nucleotide sequence ID" value="XM_014408572.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5I2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005164"/>
    <dbReference type="Ensembl" id="ENSMZET00005005389.1">
        <property type="protein sequence ID" value="ENSMZEP00005005164.1"/>
        <property type="gene ID" value="ENSMZEG00005003973.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481069"/>
    <dbReference type="KEGG" id="mze:101481069"/>
    <dbReference type="CTD" id="118980"/>
    <dbReference type="GeneTree" id="ENSGT01030000234641"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF14">
        <property type="entry name" value="SIDEROFLEXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="320" mass="35366" checksum="1F21627D195DEA23" modified="2019-02-13" version="1">MALSSFDIDAPRWDQSTFMGRLKHFFNITDCRTALLPDSRLDEAKALVESCRAGSIPPGTTAEQLYYAKKLYDSAFHPDTGDRMNLIGRMSFQVPGGMAITGFMLQFYRTVPAVVFWQWVNQSFNALVNYTNRNAASPITPKQIGVAYVTATSTALATAVGLNLYTKKAPPLVARWVPFVAVAAANCVNIPMMRQQEILNGIAVTDENGNKLGHSTKAAVKGIAQVVISRVTMAAPGMIVLPIIMQRLEKYKFMQRITFLHGPIQVMLVGGFLIFMVPAACSLFPQRCSMAVSKLEPELRDSIRSQYGDSIRHVYFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6B0</accession>
    <name>A0A3P9B6B0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Occludin b</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012771145.1">
        <property type="nucleotide sequence ID" value="XM_012915691.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6B0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005433"/>
    <dbReference type="Ensembl" id="ENSMZET00005005663.1">
        <property type="protein sequence ID" value="ENSMZEP00005005433.1"/>
        <property type="gene ID" value="ENSMZEG00005004210.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467281"/>
    <dbReference type="KEGG" id="mze:101467281"/>
    <dbReference type="CTD" id="494075"/>
    <dbReference type="GeneTree" id="ENSGT00730000110989"/>
    <dbReference type="OrthoDB" id="8867927at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070830">
        <property type="term" value="P:bicellular tight junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF34">
        <property type="entry name" value="OCCLUDIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="6 11 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="15">
        <location>
            <begin position="42"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="OCEL" evidence="16">
        <location>
            <begin position="362"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="469" mass="52692" checksum="5971BD637046EDD7" modified="2019-02-13" version="1">MPSNKHSNHSGKKRHRHSEVMSNPAFSYYSGNKVLHFYRWNSPPGVMKIMCIIIIIMCVAVFACVASTLAWDYEMSLMGGGTGLMPGSYGSGYGTGYGGTYGGSYGGSYGGGYGGSYSGYGGTKMDPRSGKGFIIAISAITFIAVLIIFIMVVSRQGTARSSKFYLASIIICAILAFLMIIATIVYLVAINPTAQSTGSMYYNQVVQMCAQFQNQVQPQGLLLNQYLYHYCVVEPQEAIAVVMGFLVFVALIILLVFAVKTRQQIRRWGPERILWEEVKVVNVGHHNSVGEWVTNVSGDPEVFVNDHNDKVGASRDYLDQLDYNKPLYLPGDSDISSYVGGLQPRLRDYDTGVESGDDLEEEDFSVLFPPILDEQERLAYKQEFDRDHQEYKNLQAELDGINQDLADLDRELDRHSDGSPEFMDALSDYNRLKDFKKSSEYQIKKKRCKYLRSKLSHIKRKISEYDRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B733</accession>
    <name>A0A3P9B733_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B733"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005713"/>
    <dbReference type="Ensembl" id="ENSMZET00005005963.1">
        <property type="protein sequence ID" value="ENSMZEP00005005713.1"/>
        <property type="gene ID" value="ENSMZEG00005004426.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000203802"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029286">
        <property type="entry name" value="AUNIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14526">
        <property type="entry name" value="AURORA KINASE A AND NINEIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14526:SF2">
        <property type="entry name" value="AURORA KINASE A AND NINEIN-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15334">
        <property type="entry name" value="AIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018250567" evidence="2">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="211" mass="24141" checksum="EB70AAD08B212AB9" modified="2019-02-13" version="1">MLICSLCLLLFTHCVLFYIFQKRRSRPISKLLNPFCEGAGYSLAVALNFTQTKTEMPKTKQSSISAFFTAHRRGKHLKVCRKPVSNHKWTQPKTASPRKQTGQLWEKAAKEESSAFQIKRTKPISSPLKRRMPQQRSRELDEDSLATLFTQDSEGFRVIAHRGLHTRSPLKDQSNVSMGVVSAYKSLPEEEEEDEEMLFTQDSQGNVVIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B956</accession>
    <name>A0A3P9B956_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutamyl-tRNA synthetase</fullName>
            <ecNumber evidence="3">6.1.1.15</ecNumber>
            <ecNumber evidence="4">6.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="3"/>
    <dbReference type="EC" id="6.1.1.17" evidence="4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006443"/>
    <dbReference type="Ensembl" id="ENSMZET00005006738.1">
        <property type="protein sequence ID" value="ENSMZEP00005006443.1"/>
        <property type="gene ID" value="ENSMZEG00005004950.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074815"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10309">
        <property type="entry name" value="GST_C_GluProRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00936">
        <property type="entry name" value="WEPRS_RNA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000006">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
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        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
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        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
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        <property type="entry name" value="S15/NS1, RNA-binding"/>
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        <property type="entry name" value="Glu_tRNA_synth_type2"/>
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        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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        <property type="entry name" value="Anticodon-bd"/>
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        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
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        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
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    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
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        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
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    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
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    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
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    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
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    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
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    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
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    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
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    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
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    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
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    </dbReference>
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        <property type="entry name" value="WHEP-TRS"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
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        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Class II aaRS ABD-related"/>
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        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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        <property type="entry name" value="GST C-terminal domain-like"/>
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        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
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    </dbReference>
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        <property type="entry name" value="WHEP_TRS_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018096129" description="Glutamyl-tRNA synthetase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="1387"/>
        </location>
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            <begin position="724"/>
            <end position="780"/>
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        <location>
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            <end position="872"/>
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            <begin position="696"/>
            <end position="722"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
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        <location>
            <begin position="867"/>
            <end position="928"/>
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            <begin position="696"/>
            <end position="708"/>
        </location>
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        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="778"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="877"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048351"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="16">
        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006443.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1387" mass="154732" checksum="62561C73BBE3D4D5" modified="2019-02-13" version="1">LKTLCCLVCLAGALLTAEHVKSSVQVSVEEGKDTRLHISDSVQFSDDNSICRYLARVAPALGLYGSNMMEQTEVDHWLEFSARSLCNQPDLTVALAELDKALSLRTFLVGHALTLADLSVWAALKDHGEWPKQGKSFSHVSRWFFFLSSQVPFTAVGNKYTSKKLEGKKADVGKFVELPGAEMGKVVVRFPPEASGYLHIGHAKAALLNQHYQVTFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLQIRPDQFTYTSDHFPTIMKFAEKLLAEGKAYIDNTPPEQMKQEREQRVESTCRNNSVEQNMKMWSEMKAGTEYGQTCCMRAKIDMNSNNGCMRDPTLYRCKNAAHPRTGNTYNIYPTYDFACPIVDSLEGVTHALRTTEYHDRDEQFYWIINALGLRKPYVWEYARLNLNNTVLSKRKLTWFVDQGYVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGGSRSVVNMEWDKIWAFNKKVIDPVAPRYTALSSSYVVPVSVPEATEEMKEIAKHPKNAEVGMKEVWYGPRVLIEGADAETFTEGETVTFINWGNLIITKINKGADGKVLSMKASLNLDNKDYKKTTKITWLAETNNSLPVPAICVNYQPLISKAVITKDDNFKDYINKHSKLEEKMLGDPCLKNLKKGDIIQLQRRGFYICDQPYEPLSPNSCKESPCVLIYIPDGHTKEMPTAGSKEKSKTQASDNTAPKTSVPAPAADLFSSIVAQGEAVRLLKAAKAPKDEVDKAVKQLLSLKAEYKQNTGKDYKPGLQAPATPAQTQTQASSASTQSNSSLQAQELFSQVSQQGDLVRKLKSEKAPKVRTYRVVLNTTKIDQVDEAVKTLLDLKSKYKTLTGQDYKPVAAAGGTGGEDKNRKEKENKSEKQGGGGGGKKGKGDKGGQSKESSGGAGGAGEGQGPKKQTRLGLEAKKEENLADWYSQVITKAEMIEYYDVSGCYVLRPWAFSIWESIKDFFDKEIKKLGVENCYFPMFVSQAALEKEKSHIADFAPEVAWVTRSGKTELAEPIACSLLFFKFLWQEGHTAFATKEEAAEEVLQILDLYARVYEELMAIPVVKGRKTEKEKFAGGDYTTTVEAFISASGRAIQGATSHHLGQNFSKMFEIVFEDPKRPGEKQLAFQNSWGITTRTIGVLAMVHGDNMGLVLPPRVACLQVVIIPCGITATLPEQEKEVLLAQCTKYLKRLQEAGIRVKSDLRDNYSPGWKFNHWELKGVPIRLEVGPKDMQQKQCVAVRRDSGAKVTIPEAEVEKNLLNMLEDIQNSLFKKASDDLKSHMVAADTMEQFQKELDQGKIVQIPFCGGIECEDWIKKITAKDQDLEPGAPSMGAKSLCIPFTPLKTLQPGQKCVSGKEPAQYYTLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9T5</accession>
    <name>A0A3P9B9T5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Toll-like receptor 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9T5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006673"/>
    <dbReference type="Ensembl" id="ENSMZET00005006972.1">
        <property type="protein sequence ID" value="ENSMZEP00005006673.1"/>
        <property type="gene ID" value="ENSMZEG00005005140.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159678"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Toll-like receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017241">
        <property type="entry name" value="Toll-like_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037595">
        <property type="entry name" value="Toll-like_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="736" mass="83170" checksum="81A69C67354D2F4F" modified="2019-02-13" version="1">MYLIHTFFEIPFSVMVTLWGRCTSQHMSRKHSQIKTLRISLRNRMMWTVGLQAVAICVFLQVPGCFPSCLIKGSIAYCGFQNLRSVPPLPPDITHLYLEMNHISEINSTSLSGLEELQVLDLGRQHAQLVIRNHAFSRQKHLRRLSLDFNVGLQLEQQAFDGLASLQILNLDYCSLKESILRDKYLEPLLSLQTLSLFGNDIKRLQPSPFFVNMTHLKDLNLKLNKIDKICESDLAAFQGKTFTVLNLNSVYLREMSSGKFDWNKCGNPFRDLTFQTLDLSSNGFGVGQCTQFFKAIEGTKISHLKMSGHMGRGFSFNNLPDPDRSTFEGLHNSSVLSLDLSKSRIFALQQGVFSSLKEVTIIDISQNKVNQIHRNAFEGLQDHLKVLNLSHNLLGEIYSYTFASLTNLQVLDLSHNHIGALGYQSFSRLPNLKLLYLTGNSLRDLGFPAPLPSLDFLLLNDNKLAPSSVRSISQFASNLMHLDLQDNRLTDLEDVSTILTGLKRLRHLFYGGNRIRSCSFSRRVSLNNLTVLDLHSSSLQSVWAQGKCLNLFDNFGHVAGLNLSFNALQSLPQGVFKGLTSVREMDLSYNALTYIQPDVFPTSLKALYLSNNFIASPNPATFRSLSFLDLRMNRFHCNADLKSFLTWLNETNVTLLSPVEELRCEFPASVYNQLKKSRNLFLLTSYSRGQPQLSQYSLTSMMLFSTVRPRLKTHQQVFSVLGFLCSNAAIRCLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9U7</accession>
    <name>A0A3P9B9U7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Si:ch211-107m4.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004545654.1">
        <property type="nucleotide sequence ID" value="XM_004545597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9U7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006688"/>
    <dbReference type="Ensembl" id="ENSMZET00005006987.1">
        <property type="protein sequence ID" value="ENSMZEP00005006688.1"/>
        <property type="gene ID" value="ENSMZEG00005005136.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469157"/>
    <dbReference type="KEGG" id="mze:101469157"/>
    <dbReference type="GeneTree" id="ENSGT00940000160376"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12884">
        <property type="entry name" value="SPRY_hnRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035778">
        <property type="entry name" value="SPRY_hnRNP_U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381:SF66">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="7">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="158"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="616" mass="68951" checksum="C82BE30A2EBDBC7B" modified="2019-02-13" version="1">MKLADIKKLKVAELRSRLKELGLDSRGLKAELVERLWSAAEGEPSGGDGEEETLKLHDSSPILLVQTEPADVRPPSSEIGATARHEVDRGYTDMATQTVAEPSPAAPQPDSEAAAAAGVTACPAEGGEQGHAEGPVEEDMGRGRSFYEFKEEIRYKRAKSPQPPAERSEAEEQDEDKVRLDKYGSHLHFEVSPDGSSGQPRFWAQFPLLWSGCRLTHGVQQGRVGFEVRLERKLLTAQPDDHEVREPYGLRVGWSVAVSSLLLGEDELSFCYDGRGKKVSDRKEENFGEPFSEGDIIGCYASFSSDGAVELSFHKNGRFVGVAFSTDTSVLRGRALFPHVLCKSCSFKLLLDPAAQPWYPGPPGFTPLATLPPGQRVCSTSAPTSRAQCEVVLMVGLPASGKSVWARNYMKQHPEKQHRLLGTEELLACMISGGQRDSRLQQASHGLTEIIKMAAQTPGNYILDQCNILFSALRHKLRLFTGFRRRVVVVFPSGDEWKRRLSQHQMRDGEHIPETALLKLQVSCSLPEQQDDLLEELQYVELPQEKALKLLQEYKDEARRLLPPVPKHEKTRRLYRKRPHPHGPPSSHRTWSQPPRYWSVPYQDQGYYYSAYQNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9Z1</accession>
    <name>A0A3P9B9Z1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9Z1"/>
    <dbReference type="Ensembl" id="ENSMZET00005006986.1">
        <property type="protein sequence ID" value="ENSMZEP00005006687.1"/>
        <property type="gene ID" value="ENSMZEG00005005156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286986"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="387" mass="43697" checksum="6225BFD7C9605526" modified="2019-02-13" version="1">MACNDFAKFFTEKIQKIRQAIGTSTADPGYVLCPPKSCLNTMKQFQPINSKDLEDILGKLNSSSCCLDVLPTSFFKKVSKTLESDLLQIVNFSLLSGVFPESLKTAVIKPILKKDNLDKTQMNNYRPISNLPFLSKIIEKAVSQQLSYFLKQNNCYDAFQSGFRQNHSTETALTKVFNDICLNTDSGKMSVLVLLDLSAAFDTVDHNILLKRLENWTGLSGTVLNWFKTYVENRKYFVSIGNFTSEQTSITCGVPQGSILGPLLFNIYMLPLAQIINNNKINYHSYADDTQIYITMSPGDRGPVQALGKCIEEINDWLCHNFLQLNKNKTEVIVFGAKEKRLQVTRELQSIHLKTTNQARNLGVVMDADLNLEKHIKTITKSAYYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BB75</accession>
    <name>A0A3P9BB75_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP glucuronosyltransferase 5 family, polypeptide D1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BB75"/>
    <dbReference type="Ensembl" id="ENSMZET00005007453.1">
        <property type="protein sequence ID" value="ENSMZEP00005007143.1"/>
        <property type="gene ID" value="ENSMZEG00005005497.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166282"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF32">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018173614" description="UDP glucuronosyltransferase 5 family, polypeptide D1" evidence="4">
        <location>
            <begin position="26"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43736" checksum="AFEAF9FC009B9174" modified="2019-02-13" version="1">MSGLSIPLILTLLCFLLLSPPPCSSSNILVVPVDGSHWINMKLILEQLHSRGHNITVLRSAKSWYIPNNSSIYTSINISTVVDESDINYYNKMLQDVMECRTYPTFIRTLCQQYLITSVLDQGHKIWAISVATIIEDTVFIQKLQDTKFDLMLTDPGMTIGMLLATYLELPIVFNVRWINTGEGHFTIAPSPISYVPVSASELHDQMDFLERIKNMLHYLYNVIEQHLIINPAYSDLLQRHFPPGADLLSLQRRADIWLFRADFVFEFPRPTIPNVVYIGGFHCKKAQPLPAELEAFMQSSGDHGVVFISLGTFISALPRKVTEAIAAAFAELPQKVIWHFVEGALHKLNSAAKPTNALRENKQPFQHIRYIDRKHRYDNEIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBQ3</accession>
    <name>A0A3P9BBQ3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 285</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004571495.1">
        <property type="nucleotide sequence ID" value="XM_004571438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBQ3"/>
    <dbReference type="Ensembl" id="ENSMZET00005007630.1">
        <property type="protein sequence ID" value="ENSMZEP00005007320.1"/>
        <property type="gene ID" value="ENSMZEG00005005628.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478572"/>
    <dbReference type="KEGG" id="mze:101478572"/>
    <dbReference type="GeneTree" id="ENSGT01150000286953"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF152">
        <property type="entry name" value="SI:DKEY-210J14.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="328" mass="36928" checksum="596D286F9F89B182" modified="2019-02-13" version="1">MTKLELLNVFLNDRLTAAAEDIFRAVKDTVVEYQSEILRSKEENERLKRLLNVAVQRLLLQSGEEHRLTALTEPHSQAQEDGQLCASECGRSAGSHVKDEQRNAQSHCSHQLSNSEEGNCRSVEPLRLNAPPAQTASLPPLTSPEVKTETDGEDSRKQQCCNSLPAAANAAQSDSRATAAKTHRTVRNEQQVKGLLRSNGKQSAHILQIKNVKSLKASSSRPHHPSQSIQRWHSCNECGKGFNFACQLEVHMRWHTKEKPYSCAVCRKSFTTVSMLKRHHRIHTGEKPFRCHVCGKCFNQSAHLNTHFRLHTRERAGWSRAPHCKLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDR8</accession>
    <name>A0A3P9BDR8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane bound O-acyltransferase domain containing 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDR8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008018"/>
    <dbReference type="Ensembl" id="ENSMZET00005008339.1">
        <property type="protein sequence ID" value="ENSMZEP00005008018.1"/>
        <property type="gene ID" value="ENSMZEG00005006092.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234564"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF7">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="517" mass="58732" checksum="7F6118DF5C3F93CA" modified="2019-02-13" version="1">MFSKFRQNTGCGYPCGCTAISKSQGPVAITVPSGLKFIFVNEQHLTSTTGYLEKSSQARLWNLSSDTGNRGSVVIKEVKHRLSPTTQEMYSLHFLVQSGLSYSVMVFAGLENMHKYCFIVTLGYLILCQITRVYVFDYGMYSADFTGPMMVITQKITSMAFEIHDGLTKREGQLTPGQKYFAISRMPSLLEYLSYNCNFMGILAGPTCSYNDYKAFIEGTCYQPRHQENANGKENGKYKQTEPSPKNDVISKLCTCAISLAVYLSLYKLLPVERSIDDDFVNSTPFHLQVVYLYLAMLALRPKYYFVWTLADAINNAAGFGFNGYNKDGSPRWDLISNLRILDIEFATSFKLFLDNWNIQTALWLKRVCYERCPINPTAATFLLSAMWHGVYPGYYLTFLTGIGMTMAARAVRHNIRPYFLVSDSYKGIYDVITWAWTQVAISYTVAPFVLLAVGPSLKFYRTWYFGLHLLCLLVVLALPVKSKRRQAKEQQDDLQKDNQTDHNSTDNNCNQKEKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BE21</accession>
    <name>A0A3P9BE21_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized LOC101472601</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSMZEG00005006191.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT01030000234567"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:binding of sperm to zona pellucida"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11576:SF18">
        <property type="entry name" value="ZONA PELLUCIDA PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11576">
        <property type="entry name" value="ZONA PELLUCIDA SPERM-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zona_pellucida"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZP_2"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="86"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="433"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="641" mass="70472" checksum="4353E00C5E80A3A5" modified="2019-02-13" version="1">MMGTTQISLCVFLGCVIAVQSVLYHNGRFTQDVVGVYENRVPFSFGRNFDFTPQGTIFSSWRSWTPDFHRLAGLSPFLNVPRVQVYCDASTLTVLVDKSVSGLKLTGEEIQLGNGCFSNGELANEFVFTYGFGECGTTPMVEDDLEVFTNTLFLNLRRISPTWWETPSAVHVFCVAKRLNKIPKFSDTALPENDDISIKAMSPSWTSAAESNIYKRGQLVNLQVLAKTRINQEAFIQSCFVSVFPEPRAKPRQTVIFNKGCVTPLGSSTTRVTFVASNSADAVNFVLNTSYLISELYIHCSVLISGQGVTPGSKSCNYNVIESRWEELSGDLEACECCSSRCKGKNLPGDAKAVVSTGPFVIVDEDGERTLPSIAEEESANVPNSMQSALPDLADVIVSSVPRSKFNAGPEGVVAVSQDPATRLTLWLPEQVPPQSDSNDITKLHSSTTNQEPHPNPTNEIKGQSFSSVSPSTMNLPTIVNGWKSPPHPAVPEDFKRKSRSGRSGNFDSKEEPVNFSLPAEISVKYLMLVERPNSAELDNTAAVEESQSEKWLQNEIKDPNHDDLPQMLTDGAMMPEGTDEIPPITRSKLSFSKAADGSQTLSYEEEAVVHKTSPVERKQLKLKGLHSTFLNLLRRMKNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEN1</accession>
    <name>A0A3P9BEN1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tumor protein p53 inducible protein 13</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004567069.2">
        <property type="nucleotide sequence ID" value="XM_004567012.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_004567013.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEN1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008348"/>
    <dbReference type="Ensembl" id="ENSMZET00005008681.1">
        <property type="protein sequence ID" value="ENSMZEP00005008348.1"/>
        <property type="gene ID" value="ENSMZEG00005006375.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000008202"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179:SF1">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018016716" evidence="3">
        <location>
            <begin position="26"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="598" mass="66622" checksum="6CF764B9E8177630" modified="2019-02-13" version="1">MPREATSAPLTVTVLAVLWVSVGRCHVFGSLGQGCDNGKLSLERDLPADAVYWDCAASAWPEFTQRLPSIDTAYNPEPARQICMDKSISYYHRIPNSGAYRPIGAESGEYLYCPPQRWLNNLQRGAAVLLYHPCAPPRERQILSDLARSCLQSYILTPHPQLNKHMPVAFVSWGRTLELSTAASLDLCDWLEVNHRDQTSRKESDGVTQMRKYALLLTWSAELHQLEQTTKMKDSLRQCCERTIYSLLSGATEAELEHSVKTERSKQTKVGSKTRQMRAALKVVDSNESNNTMANVSRTVPQRSGDGQNNSSTLGSSADQRKPFDLSSSREAPQVPTQASKPRLTAPLALNISETEAQKGLRKLNHSPVSAHGVSSKRTFTDRPEALILKETDSIKHNTKVDKSKEKIFDSSDGNMEDNEVVDVKERELEHTQIQCAPGSHQKSESTGSDFVPKPQSEAQAQQHPQTASHSQPISRDCNSCAPGEHCDCVKASGSEAQAAAAVVYRELQRTPRTDEAAWAAAALGFLLVLLTLSVLHTRLYRHWRITPSLYWHNPSDDYDSVADVIRRRLRIAKRRQKRGRRQECVLLPSSSSSDECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGA6</accession>
    <name>A0A3P9BGA6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Sortilin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Cell membrane</location>
            <topology evidence="21">Single-pass type I membrane protein</topology>
            <orientation evidence="21">Extracellular side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Golgi apparatus</location>
            <location evidence="23">Golgi stack membrane</location>
            <topology evidence="23">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Nucleus membrane</location>
            <topology evidence="22">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the VPS10-related sortilin family. SORT1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554310.1">
        <property type="nucleotide sequence ID" value="XM_004554253.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGA6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008954"/>
    <dbReference type="Ensembl" id="ENSMZET00005009298.1">
        <property type="protein sequence ID" value="ENSMZEP00005008954.1"/>
        <property type="gene ID" value="ENSMZEG00005006789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483207"/>
    <dbReference type="KEGG" id="mze:101483207"/>
    <dbReference type="CTD" id="799153"/>
    <dbReference type="GeneTree" id="ENSGT01030000234563"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000802">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF44">
        <property type="entry name" value="SORTILIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 28" id="KW-0732">Signal</keyword>
    <keyword evidence="6 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 27" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018104834" description="Sortilin" evidence="28">
        <location>
            <begin position="20"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="29">
        <location>
            <begin position="122"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="797"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00060431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00061605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00068731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="823" mass="91426" checksum="9175F937881A34EB" modified="2019-02-13" version="1">MGLLLRGILLLSACTFTAGVDFQLGSKPLGQSGFVRRSNTEGKAAKIVKRSLPAWLAPSPNHKIKRRSTEEDDSCKALQGYVTKLDANTHDFEFHDLSGSVSLAWVGDGTGVILALTTFQVPFFMVKLGQSKLYRSEDYGKSFQDVTGLINNTFIRSEFGIAISPNNSGKVILTAEVSGDLKTRIFVSEDFGKSFTDRNLPFNPLTQITYNPENSSVLVVLSNDYELWLSEDFGVNWKNIHRMVCLVKWGRKNTIYFTASLNGSCSDRGMLELRRTTNYGKTIKTVASKIYSFGLGGRFLFASVMTGKGTLRTIHVSVDQGDSWNIAQLPPVGHEQFYSILAANDEMVFMHVDEPGDTGFGTIYVSDDRGTVYSKSLERHLYTTTGGDTDFTNVTSLRGVFITSVLAEDNSVQSVVSFDQGGEWVPLQKPANSKCDATAKDPDKCSLHIHAAYSTSQKLNIPMLPLTEPNAVGLIIAHGSVGDAISVMRPDVYVSDDGGYTWIKALDGPHHYAILDSGGLLVAVEHSVTNPVNKIKFSTDEGQCWNEYNFTKDPIFFTGLASEPGARSMNVSIWGYRDSYLSQYWTSFTIDFKELLTRTCGDYDYVQWLAHSDDISDPNDGCLLGYKEKFLRLRKDSVCWNGRDYIVNTQPTPCLCTLDDFMCDFGYYRKENSSECVEQPDLRDKVLEFCLQGKEEQLQTSGYRKIPGDKCEGGEVHMRKEIDLSKRCVSDLVGPELLVDNKASKSVPVVITVVIVLILSIPVGVVFVKKYVCGGRFLVHRYSVLQQHVEANAADGIDEPLETNHTQNGKIEFHDDSDEDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJL0</accession>
    <name>A0A3P9BJL0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJL0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010139"/>
    <dbReference type="Ensembl" id="ENSMZET00005010507.1">
        <property type="protein sequence ID" value="ENSMZEP00005010139.1"/>
        <property type="gene ID" value="ENSMZEG00005007647.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155570"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:microtubule binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:microtubule depolymerization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:microtubule-based movement"/>
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    </dbReference>
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        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF24">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="187"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="616"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="662" mass="75652" checksum="7A8EAA41928A7DA1" modified="2019-02-13" version="1">AMAGMFGKIFVGIYVEIKRSDGRIHQAMVTSLHEDNESVTVEWIENGDTKGKEIDLESVFALNPDVAPDEEIPQSPEAPVPPSNVAKTSKVPKVCFSTPDIINQSLLFATVLLVFSARRKSNCVKEVEKLQEKREKRRLQQQELREKRAQEVDVNLPNYEIMCMIRDFRASLDYRPLTTNDLIEEHRICVCVRARPLNKKELSTKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDENSTNEMVYSRWLRPFLRGEWRLFDFDLRSLVLTMGGDFSGKNQDCSKGIYALSARDVFLMLKKPNYKKLDLQVFATFFEIYSGKVFDLLNRKAKLRVLEDGKQQVQVVGLQEREVKCTEDVLKLIEVGNSCRTSGQTSANAHSSRSHAVFQIILRRRGKMHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVDPAAAMMESHQGGHITQLEVLEAQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQLVEMEEQVLEDHRAVFQESIRCLEDEKVLLEMTEEVDYDVESYATQLEQILDQKIDILTELRDKVKSFRCTLQEEEQASKQITPKRPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BK57</accession>
    <name>A0A3P9BK57_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BUD31 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BK57"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010031"/>
    <dbReference type="Ensembl" id="ENSMZET00005010397.1">
        <property type="protein sequence ID" value="ENSMZEP00005010031.1"/>
        <property type="gene ID" value="ENSMZEG00005007593.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014300"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="103" mass="11931" checksum="50A953740124EA13" modified="2019-02-13" version="1">MPKVKRSRKPPPDGWELIEPTLDELDQKMREELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BKL0</accession>
    <name>A0A3P9BKL0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein 33</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004559321.4"/>
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        <property type="component" value="LG19"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="492" mass="55137" checksum="DE9262108E6DAFE3" modified="2019-02-13" version="1">MALCGGVGAMALPSELIVHIFSFLSDRDKLRASAVCSRWRECLFYPALWTELKLRIGGGGCSSSDETPKLEFLMRKFGSFVRDLQLELAPVEGNLSHQNSDPSSARVDQPPGPDSDPQHKERWRDAVATYLDQVLCVFTSIRNNRNLQKLSLYGDTFILQQEGLLDSSHLHVIHQGDKKINEIQQLFMEVLSNSRQLRWLSCSFMLGLVTSCSLSCLSNPSAETLQHLSLLDHQLGPLVSPSELDRLSNLHSLALDFTDFTSELCGLLASPRRTPLHRLSLLLNGATLEFKSLEGTATEDNWKALVRVSANLRVYVMALEVDSSELLRVLKPSLPLERLHLDSYSMPVTDATLELISQQYNKTLTHFLLLRDGPDFPDLSINRNEDPLVLLTWRCTQLAVLVIHGYTVWSHNLVAISRLRGSSLRVLTVSEESIDFDPDQSVCVEGDPVHNLVKEVSLGLGRVWQPCLDSSVFLSEPTQHFHHELRAFSMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLT2</accession>
    <name>A0A3P9BLT2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLT2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010878"/>
    <dbReference type="Ensembl" id="ENSMZET00005011256.1">
        <property type="protein sequence ID" value="ENSMZEP00005010878.1"/>
        <property type="gene ID" value="ENSMZEG00005008163.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234522"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026523">
        <property type="entry name" value="PNMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048270">
        <property type="entry name" value="PNMA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23095:SF51">
        <property type="entry name" value="PARANEOPLASTIC ANTIGEN MA1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14893">
        <property type="entry name" value="PNMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="465" mass="52165" checksum="83F9ECCE6F317F60" modified="2019-02-13" version="1">IPSTLIQIQKNNPNRAFVLHDVPSDFDLSDIEETAQSVKAFGRVKVRDRLRDTQTGNNLVLCECRQDIQPDRIPPHVQPLNGGPVWKISLLTESVRSADDFSAKLKKLMVEEGKTIYDVSALLSTETPQENSPESILRAVGDLLAKTMRPTSENTASRRLRIFSGHSSTPAGEESLDSWVEQARLMIEECDCSEREKRRRVVESLKGPALEIIQAVWRDNPDASPESYVEALESAFGSLESGEDLYLAFRSLGQQRGEKLSDFLRRLERSLTKVVQRGGLPSHRVDRARIDQLIRGATQSEIMLLQLRLRERKEEPPAFLKLLSEIREEEDHARLRSELKELTSKRSDAELMLKQTKKVAEAGAENELTVMAVSQGSTQTDSTKRDGRARRSKVNRPYAAKDSESYFCYRCGENGHIATRCMAPENTAKVIQRLLGALRRSKEGKGATGGASEPTQVAQNQRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BR40</accession>
    <name>A0A3P9BR40_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">La ribonucleoprotein 1, translational regulator</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LARP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561838.1">
        <property type="nucleotide sequence ID" value="XM_004561781.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BR40"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012420"/>
    <dbReference type="Ensembl" id="ENSMZET00005012859.1">
        <property type="protein sequence ID" value="ENSMZEP00005012420.1"/>
        <property type="gene ID" value="ENSMZEG00005009345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475877"/>
    <dbReference type="KEGG" id="mze:101475877"/>
    <dbReference type="CTD" id="23367"/>
    <dbReference type="GeneTree" id="ENSGT00940000159577"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08034">
        <property type="entry name" value="LARP_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000131">
        <property type="entry name" value="la-related protein 1B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF51">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="387"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1063"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125924" checksum="AB8BFDD0B7BDD177" modified="2019-02-13" version="1">MATQVEALLPGNPLAQAKEHGKVIRSEPKEEASGRGDGDKRQTGVADQGSGGGGSSSPGQGGTTGSEEQTSKRATEESKGGCDSEDKLSEEGVKGGGGNKKDFTEAPPPKVNPWTRKMNAVTVVSVNGQAHHESTGPAKVVRAGNPPKARRGGKVGDFGDTNSWPTPGEIATKDMQIEAVTRTVSCPPTVRQVRDSWKFTGTKKTMVKKESKEKRESNEESKENVKAKSDDSGEEKNGDDDSQKNGPKKKGNKQKWVPLMIEVKSEGPRERSASRNNSRQNENPRLPPNARNDLRDWHSQKYEREWRDDHDEVSSVKSEGAPFRGGFRGRGRGRGRGRGRGRGAGRGHYDYHYSYKSYDVKDGPYGQKFSNSVTYYYDNMSSNDLYSVDQDLLKDYIKRQIEYYFSLDNLERDFFLRRKMDQEGFLPIGLIASFHRVQALTTDVNIILDALKDSKEVEIIDMKIRRKVDPEKWPLPGLNMPNMPHTHTDFSQLINCPEFVPRQMAEEPRGLPRASTPMQQQTKAEPDVSNLKTMPKGLSASLPDLDSESWIEVKKRPRPSPARPKVSSEKSSSLHHQQQKEKDESIRSPVPQPGSSPSAATSGNKDGAEQDEPEELDFMFDEEMEQMDGRRNTFTDWSDEETDGEIDDHDVNKILIVTQTPPYLRKHPGGDRTGHHTSRAKLTSELAKVINDGLFYYEQDLWDDTYEPEYATIKQEVENFKKVHLISREQFDCLTPEPPVDPNQEVPPGPPRPQQIPTDALANKLFGAPEPSSIARSLPTTVPDSPNYRSARTPRTPRTPHRKDPTMTPRFYPVVKESRPVDAKTPRKRKTRHSSNPPLEFHVGWVMDSREHRSRTASVSSNASPSEGTPALGNIGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNRKMYEEFRQLVVEDGKEGYRYGLECLFRYYSYGLEKKFRPDIFKDFQEETMKDYEAGQLYGLEKFWAFLKYSKAKNLEIEPKLQECLSKFKRLEDFRIDPPMEEGSRRRHSSSGDGRRRHPSQPSSRPHSQASSGPTHATTTQVPTAKDDAKPTSHKAPAPTADPASNAKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BS30</accession>
    <name>A0A3P9BS30_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
            <ecNumber evidence="10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine. Can dephosphorylate MAPK1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10685"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with MAPK14; this interaction does not lead to catalytic activation of DUSP2 and dephosphrylation of MAPK14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EC" id="3.1.3.48" evidence="10"/>
    <dbReference type="RefSeq" id="XP_004547119.1">
        <property type="nucleotide sequence ID" value="XM_004547062.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BS30"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012441"/>
    <dbReference type="Ensembl" id="ENSMZET00005012880.1">
        <property type="protein sequence ID" value="ENSMZEP00005012441.1"/>
        <property type="gene ID" value="ENSMZEG00005009360.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484664"/>
    <dbReference type="KEGG" id="mze:101484664"/>
    <dbReference type="CTD" id="1844"/>
    <dbReference type="GeneTree" id="ENSGT00940000161605"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031103">
        <property type="term" value="P:axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001706">
        <property type="term" value="P:endoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000034">
        <property type="entry name" value="Dual specificity phosphatase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000015">
        <property type="entry name" value="Dual specificity phosphatase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF109">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000939">
        <property type="entry name" value="MAPK_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="171"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="314" mass="34880" checksum="5DD7AAB540125122" modified="2019-02-13" version="1">MNPINEPLEITGNELVHILRTPREQYTSAGCVVLDCRPFLDFSLAHICESRNVNWNAMLRRRSKSSVVALEWLIPDKTLRARLQSGEFSPVVVVDERSSSMAELKAESVSQMLLTALQNEVHTQICFLQGGFGAFSEAYPELCYTSTINHCAVEPEPKVTGRRTPAYDQDGPVELLPFLFLGSAIHSSRRETLAAAGITAVLNVSSTCPNFYEGEFQYLRLTVEDTLAADIRACFSAAIAFIDSVKQSGGRVLVHCQAGISRSATICLAYLMHTQRVRLDEAFDFVKQRRHVISPNLAFMGQLLQFETDVLCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BS87</accession>
    <name>A0A3P9BS87_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BS87"/>
    <dbReference type="Ensembl" id="ENSMZET00005013239.1">
        <property type="protein sequence ID" value="ENSMZEP00005012795.1"/>
        <property type="gene ID" value="ENSMZEG00005009606.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044904"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="218"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="763"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1038" mass="118937" checksum="6A7507DAE9EED327" modified="2019-02-13" version="1">MRKSQLRLENNSMDQMIQEREQKIQELQQSVKTSRSKAEEALSYSRKVMTALVQHIKTEFTRLSEAIETKQEINETEAESFIDELQAEITHMKKKKLQFHEASLIRDPFSFLENVLPLTYNKPQLQDWSAVTVTSDQFMIQETLDQLETKVREEVSMLCNINFRCGKQQRTSNVSKYKDIISRSDLISSGPPAVYQLRAKKQKFGTRMTVGEKKQDKPNRTILLVGETGAGKSTLINALLNYTMGVKWEDEVWFTIVEEKKKKTQTEGQTESQTEGQTESQTEGQTESQTEGQTESQTEGQTESQTEGQTESQTEGQTESQTSDVMVYEIFGFEDETLPYSLTIIDTPGYGDTRGTEHDDIISYRLLDLFGSDDGVHEIHAVGLVMKASDNRLSDRLLYVFDSVMSLFGKNLEKNIVALITHSDGRRPKNPLQALEDWNIKCAKKGKNQPVYFLFNNCQLEDEEEEFLTLNFERSERGVREFTAFLKESTPVQPEATPEVLKERIRLTACIQNLQERIRFTEVKQREMKQTREALQKNEVVTPCVVFKHKEPIRAETCGPGLKAAVSCTVCEENCHYPGCTVPLNHCEVFRDGLCTSCTNKCPASVHVKGKRRYVTRIRRGQKNEPPAEDKDVYLLGKEMNRLTAEKEKWFNESYQHVVRLEQIALKADSVSTVVHLDFLIEKMKQKGDTEKVQKLEEMRRREDKRSKGAQRISLISSPHEDIISDSFLIRSGPPAVYQLRPKKEMIGTLTRITVGEKNLIKTNRTILLVGETGTGKSTLINALLNYTMGVKWEDEVWFTMVEEKKKRGQTGGQTESQTSDVIVYEIFGFEDETLPYSLTIIDTPGYGNTRGIEHDDIISHRLLDLFQSEDGVHEVHAVCLVVKASDNRVSDRLKYIFDSVMSLFGKNLEKNIIALITHSDGRIPENPLKALEVAEIKCAKNEKNQPVYFLFNNSQYESRTEENKSSKLSWELTQENMNQLTDFMGNSNPQKLMKTAEVLNERIRLKACIQNLKERIELGELKQTEIRQKREALKKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVJ8</accession>
    <name>A0A3P9BVJ8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Immunoglobulin heavy variable 6-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVJ8"/>
    <dbReference type="Ensembl" id="ENSMZET00005014128.1">
        <property type="protein sequence ID" value="ENSMZEP00005013661.1"/>
        <property type="gene ID" value="ENSMZEG00005010286.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286938"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:003074">
        <property type="entry name" value="Immunoglobulin heavy variable 11-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="101" mass="11532" checksum="54303FCBFCF49E9E" modified="2019-02-13" version="1">GQTLIESKPVIKRPGESHRLTCTGSGFTFSSYPMNWVRQAPGKGLEWIAFVHTRSSHFFYSQSVQGRFTISRDDSSSKVYLQMNNLKTEDTAVYYCARQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BX69</accession>
    <name>A0A3P9BX69_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">N-acylethanolamine-hydrolyzing acid amidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
            <ecNumber evidence="16">3.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Acylsphingosine deacylase NAAA</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N-dodecanoylethanolamine + H2O = dodecanoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:45456"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:85263"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:45457"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:41291"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:72956"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41292"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N-hexadecanoylethanolamine + H2O = ethanolamine + hexadecanoate</text>
            <dbReference type="Rhea" id="RHEA:45064"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:45065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate</text>
            <dbReference type="Rhea" id="RHEA:38891"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38892"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N-tetradecanoylethanolamine + H2O = tetradecanoate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:45452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:85262"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:45453"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>an N-(long-chain fatty acyl)ethanolamine + H2O = a long-chain fatty acid + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:17505"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15897"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="3.5.1.60"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:17506"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:20857"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer of an alpha and a beta subunit, produced by autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 26">Belongs to the acid ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EC" id="3.5.1.60" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BX69"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014231"/>
    <dbReference type="Ensembl" id="ENSMZET00005014707.1">
        <property type="protein sequence ID" value="ENSMZEP00005014231.1"/>
        <property type="gene ID" value="ENSMZEG00005010716.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063548"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047412">
        <property type="term" value="F:N-(long-chain-acyl)ethanolamine deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01903">
        <property type="entry name" value="Ntn_AC_NAAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.10:FF:000003">
        <property type="entry name" value="N-acylethanolamine-hydrolyzing acid amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016699">
        <property type="entry name" value="Acid_ceramidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF4">
        <property type="entry name" value="N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017632">
        <property type="entry name" value="Acid_ceramidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 26" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10 26" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 28" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018203236" description="N-acylethanolamine-hydrolyzing acid amidase" evidence="28">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="30">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="29">
        <location>
            <begin position="115"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="27">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRNR" id="PIRNR017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR017632-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="353" mass="39492" checksum="F82EADF0B021408B" modified="2019-02-13" version="1">MERTTLLLLLGLAVSCRAQFAPPTVNISLDEDPAVRWMPLAKVFDIDYVNKAAVEVIDSTIPKWLHHAVKPIVMALEKYVPQPYAGEIRGLASHLGGTLSDVILLNFAYEVSAFCTSIVAQDTKGHVYHGRNLDYPHPVLKNLTFNAVFLKNGKEVYRGTSFAGYVGLWTGQSPNKFTVSGDQRGTEHWYNWWKNIVSAFLYKRSPVSWLVRETLEEAEDFQDAVMRLSKVPIITGVYYIVGGVRAGEGVVITRDREGPADIWPLETAKGGWFRVETNFDHWLPPPAKDHRREAANKALNATGQAHINMNTLYQVLSLNPVCNGITIYTTVMSAAAPEKYITLLRLQDCNKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY95</accession>
    <name>A0A3P9BY95_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BY95"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014837"/>
    <dbReference type="Ensembl" id="ENSMZET00005015325.1">
        <property type="protein sequence ID" value="ENSMZEP00005014837.1"/>
        <property type="gene ID" value="ENSMZEG00005011169.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159677"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000066">
        <property type="entry name" value="UDP-glucuronosyltransferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF161">
        <property type="entry name" value="UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018079465" description="glucuronosyltransferase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="581" mass="65724" checksum="800423245F1D4A4B" modified="2019-02-13" version="1">MRTAGVFVFLLLNVVMEITGAVDNTKGSSSEKSSPKNKLKTEEAELPHTKPASFSLFLGKLLVVPMDGSHWIGLKAIAQEMGRRGHRVTVVMPETTMRMGPGKHYETLTYPVPYDKAYIDSVMSTHKDIMKKSSQPFMEKIKKRFTQFQAISYIPHITAEKLLFNASLISHLSQQDFDAVLTDPMFPMGSLVARKLGELLCTQVICLLVHLHIFSPIITQSLPGLPTVNLLRGIPCYLDMKSAGCPSPPSYVPRYFTGYTDKMSFKERFINTLVALVEPLFCKLLYWRFDQIARDFLGENVGVAEVLSDSDIWLLRNDFTLDFPRPLMPNIVLVGGINCNVKHPLPPDLDSWVSGEHGFVVFTLGSMVSDLPEEITSVFLEAFRQIPQKVIWRYTGKVPDNVPENVKMMKWVPQNDLLAHPGARAFITHAGSHGLFEGLCHAVPMLMVPLNGDQPDNAARMASRGVGIVLNILDINTETLLKGLKEVINDSRYKENVKKLSDLHNDRPSDPLELSVYWTEFVMRHKGAKHLKSTLHELYWFQYFSLDVIVLLTTVVLVFVMLTAKCMKLCFRKVRRKWKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYF7</accession>
    <name>A0A3P9BYF7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYF7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014897"/>
    <dbReference type="Ensembl" id="ENSMZET00005015385.1">
        <property type="protein sequence ID" value="ENSMZEP00005014897.1"/>
        <property type="gene ID" value="ENSMZEG00005011202.1"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045211">
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        <property type="term" value="F:ionotropic glutamate receptor binding"/>
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    </dbReference>
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        <property type="term" value="F:synaptic receptor adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PDZ_SHANK1_3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 and multiple ankyrin repeat domains protein 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_6"/>
    </dbReference>
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        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="SHANK"/>
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        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
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        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
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        <location>
            <begin position="13"/>
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    </feature>
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            <begin position="137"/>
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            <begin position="145"/>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYK4</accession>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="25"/>
            <end position="56"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="56" mass="6154" checksum="4D725A693AE2A1C0" modified="2019-02-13" version="1">MKTFSVAVAVAVVLTFICVQQSSAVPVTEEQELEEPMSMDYPAAAHEQILVDSWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZ31</accession>
    <name>A0A3P9BZ31_9CICH</name>
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        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Alcazar R."/>
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                <person name="Berlin A."/>
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                <person name="D'Cotta H."/>
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                <person name="Haerty W."/>
                <person name="Harris R.M."/>
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                <person name="Penman D.J."/>
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                <person name="Rakotomanga M."/>
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                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
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                <person name="Young S."/>
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                <person name="Okada N."/>
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                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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                <person name="Streelman J.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
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    <dbReference type="AlphaFoldDB" id="A0A3P9BZ31"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Si:ch211-153b23.4"/>
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    </dbReference>
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        <property type="entry name" value="DHBP synthase"/>
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    </dbReference>
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        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
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        <property type="entry name" value="Sua5-like_dom"/>
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        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF17">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZM0</accession>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="Conte M.A."/>
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                <person name="Gnerre S."/>
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                <person name="Venkatesh B."/>
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                <person name="Streelman J.T."/>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
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                <person name="Ponting C.P."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030292">
        <property type="term" value="F:protein tyrosine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18500">
        <property type="entry name" value="BACK_IBtk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18301">
        <property type="entry name" value="BTB1_POZ_IBtk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18302">
        <property type="entry name" value="BTB2_POZ_IBtk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000105">
        <property type="entry name" value="inhibitor of Bruton tyrosine kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.30:FF:000011">
        <property type="entry name" value="inhibitor of Bruton tyrosine kinase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="249"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="558"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="775"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1129"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1166"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1343" mass="146698" checksum="BBBAA97787BD4AC5" modified="2019-02-13" version="1">MNQAPLDCTPKCRSQQHADQVVAALTSGSEGQLRAFLTSHCHNAATLRDAFGRTALHLAASLGKKALLEWLLEIKSADLMLKDKESGWTALHRSAFYGQIHCLISLVKHGGLLSTQDKEGLSVLDLTMKDRPSHVLFRNTDPTEVYTWGNNTNFSLGHGNQESRQHPELVDVFARTGVYIKQVVLCKFHSVFLSQKGQVFTCGHGQGGRLGHGDEQTYLVPGMVEGLMSHHCSQVAAAKDHTVVLTEEGYVYTFGLNTFHQLGLVPPPASAFVPKQVFSKMLKGRTVIGVAAGRFHTVLWTREAVYTMGLNGGQLGYLLDPNGEKCVTAPRQVSALHHKDVAISMAAASDGATVVVTEKGDVYLLADYQCKKMASRQLNIRKVLVSGGSLDHRVAPQILNEGGAEKVVILALDTAGRVFCWRSTGSSVRQCRWAYARQVFMADIALSKNSMMFVTQDGEGFSGVWAGEYKKYGEKKEGSVEVCGHSDVGTLYERIRLEKLPYVHRAVSITMDSKGRNFGVLQADPKTSLYEVPSISPSSFSQHFGSLLDEADEMDSIHDVTLQAGDRTFPAHKYILSMRSEFFRKQFMSEHCGVDEELDKEVRKSEDAVGCDLLILEKIPPDMMEYALHFIYTDSCELLVHGARPRVSGVITVPNQDSEEGRLISSLQDLGLSGRSALEVYRSLPPAAKGNSDKAKGKGSKPGKKGKGSKGDKAGANEGGANPVKTLQGVAKKLGLGSLSARLDGVKYENGKINVTNKKTGNKPKFYQKKCSYLCDVTLKSEDGKEFSCHKSVLCARLEYFNSMLGNPWIEATSCSALEMPTSSEILQVILEYIYTDESPTIKESLNVEFFCNVLVVADQLLITRLKEMCEVVITENLTLKNAAELLEFAIMYNAEQLKLSCLQFIVLNMAALLESKALDILSDEVLVELSAAYRKMIPAMQKRVITPYPGAPDLSMYEDEDLDSTFSPKPEADLDHSCREILLKKAKMKAKKKPRRRSDSSGGYTLSDIIQSPPAAVVSPCLVKSGKVNSTESLQELLTSDSEGSYMGVGSPRDMQSPVFHERAEDEKTFSQRLKTPPSTPTSIKNCLPTPPNSAPQTIPKVLPCPARAPPVLDLRTIMDMEANSLQTLGATPKSPGSVSTSIKHSPLSTKLSQKQRKMLAMANKEASAESTASKPTPTATPSKSSGKAWVTAVQSPPSSCSFRALLEEEENHLIRAGQTGTQRGQSTLGSPIVAAPAARRVTFKCAEGSESERPAGPWVLGAVGSPPLSSLVTFASIVEEEKQQEAALIRSREKPLALIQIEERAIQDLLFHYKAHDNPDELIVVERSSRGPIAVPTWNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C378</accession>
    <name>A0A3P9C378_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Regulator of microtubule dynamics protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Protein FAM82A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Protein FAM82C</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RMDN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564785.1">
        <property type="nucleotide sequence ID" value="XM_004564728.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C378"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016710"/>
    <dbReference type="Ensembl" id="ENSMZET00005017243.1">
        <property type="protein sequence ID" value="ENSMZEP00005016710.1"/>
        <property type="gene ID" value="ENSMZEG00005012547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466286"/>
    <dbReference type="KEGG" id="mze:101466286"/>
    <dbReference type="CTD" id="55177"/>
    <dbReference type="GeneTree" id="ENSGT00950000182992"/>
    <dbReference type="OrthoDB" id="512473at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF18">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="138"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="484" mass="54138" checksum="678087C0BA706CC4" modified="2019-02-13" version="1">MSVPLGRNGLVGLAVGATAGLGLIAFLVYRQISRRRSQSLVLETRPAARLFIGEDGGALLGDTLDAQEMEAQQQALAAVEAVVQGLSPEQQLELRNQLDQVLNCVASLRSEVAELRGGLQDIAWQIIQDVKKGVEDSQRVRRRRHAVHRERADSSSSTYFTASQGMASTCGETSEGGYSTAYAESDYTDRDTDREEGEQEPEQESEDEDRSCATVLTLRQDVSQEEELEERGLEDEEEEELMSEVPSGELALLLAQSDILHTGDASLKAEGFRLLMDNRAEYGDSREFLWRLARAYRDMYDSTEDKQEKKTYAQQGRDEAELALKKNGLNAECHKWFAMLAGLTSQHESMHSKLKSSCILKEHLDRALALRDDDPMCFYLLGRWCYQVATLDWLEKKAAAAHYQSTPTSTLHDALESFLKAEELSPGISKTVRLYIAKCHKELGNISEATNWAELALKMPRNTENDQETCELEAELQDLTARNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3G2</accession>
    <name>A0A3P9C3G2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM domain only 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004564541.1">
        <property type="nucleotide sequence ID" value="XM_004564484.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3G2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016667"/>
    <dbReference type="Ensembl" id="ENSMZET00005017201.1">
        <property type="protein sequence ID" value="ENSMZEP00005016667.1"/>
        <property type="gene ID" value="ENSMZEG00005012518.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477132"/>
    <dbReference type="KEGG" id="mze:101477132"/>
    <dbReference type="GeneTree" id="ENSGT00940000153908"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09388">
        <property type="entry name" value="LIM1_LMO1_LMO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09389">
        <property type="entry name" value="LIM2_LMO1_LMO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000016">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF2">
        <property type="entry name" value="RHOMBOTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="155" mass="17794" checksum="23E57922284B17BD" modified="2019-02-13" version="1">MVLDKEESVSLVSLQSREKPRGCAGCNGKIRDRFMLQALDRYWHEDCLKCACCDCRLGRLGSTLYTRANLILCRRDYLRLFGVTGNCAACSKLIPAFEMVMRARDNVYHLDCFACQLCRQRFCVGDKFFLKNNMILCQLDYEGGHLNGSTERQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3N4</accession>
    <name>A0A3P9C3N4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3N4"/>
    <dbReference type="Ensembl" id="ENSMZET00005017413.1">
        <property type="protein sequence ID" value="ENSMZEP00005016873.1"/>
        <property type="gene ID" value="ENSMZEG00005012676.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286952"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001927">
        <property type="entry name" value="Zinc finger protein 1184"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="308" mass="33981" checksum="CAF805640CA6E231" modified="2019-02-13" version="1">YSQLNDEQGGTTREEEKWTECSCRHICELCEKSYTQAGHLKTHQIIHSGVKACAECGKSFTQAGHLKTHQITHSGVKPYICDLCGNSFTQAGSLKTHKFIHSGVKPFRCDLCGKSFTHLGSLKTHQLIHSGVKAYSCDLCGKSFSQPGHLKTHQLIHSGVKAHSCDLCGKAFTRSSHLRSHQVTHSGIKPYSCDICGKNFKGYLKTHKLIHSGVKAYNCELCGKSFTYPRSLKTHKLIHSGVKPYSCELCGKSFTQAESLKTHKLIHSGIKAYSCELCGKSFTQAGSLKTHRIIHSARLTENGSELTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3U7</accession>
    <name>A0A3P9C3U7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Formyl peptide receptor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the chemokine-like receptor (CMKLR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3U7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016792"/>
    <dbReference type="Ensembl" id="ENSMZET00005017328.1">
        <property type="protein sequence ID" value="ENSMZEP00005016792.1"/>
        <property type="gene ID" value="ENSMZEG00005012619.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230438"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004875">
        <property type="term" value="F:complement receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000826">
        <property type="entry name" value="Formyl_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225:SF68">
        <property type="entry name" value="C3A ANAPHYLATOXIN CHEMOTACTIC RECEPTOR-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24225">
        <property type="entry name" value="CHEMOTACTIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00526">
        <property type="entry name" value="FMETLEUPHER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="53"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="318" mass="36071" checksum="01F715DF4A9833B3" modified="2019-02-13" version="1">LLFNYEEYIKVTNSNSTSNSCIHISTTTPEIRKSLITVSIIFHFLIFLLGVLGNGLVIWVTGLKMKKTVNTVWYLNLAVADFIFVAFLPLNVINLALDFHWPFGNFMCKLNTMVLILNMFASVYILVVISADRCVSVVWPVWAQNNRNVRKALFVTLESPNILRQFRYPPIIIARFLVLFAVPFSIIVSCNAVIIHHLRRNHTLARKSGRPFKIIVAIIITFFLCWSPIYIMDLIVLAKEMDTSSGVIGIPLATNLAFLNSCLNPLLYVFVGKDFKKEVCKSILAAMETAFQEEEKRSQSYTKSRYINPSDSEENGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3X0</accession>
    <name>A0A3P9C3X0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3X0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016744"/>
    <dbReference type="Ensembl" id="ENSMZET00005017280.1">
        <property type="protein sequence ID" value="ENSMZEP00005016744.1"/>
        <property type="gene ID" value="ENSMZEG00005012583.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160597"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="154" mass="17320" checksum="AAC24E3E4BD05AAC" modified="2019-02-13" version="1">MMEIPPRASALVCIQTYRKNQRFILVLFHSNGNANTNLSLLTDRVFAADETTSQLYNGIAKPLVVSTVEGYNGTIFAYGQTSSGKTFTMMGTSRTPGVIPQAVEDVFQSIKNFPKKEFLLRVSYMEIYNETVTDLLVDSWKRKPLEVREQINVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4G1</accession>
    <name>A0A3P9C4G1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nonsense-mediated mRNA decay factor SMG9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMG9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004541635.2">
        <property type="nucleotide sequence ID" value="XM_004541578.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004541636.2">
        <property type="nucleotide sequence ID" value="XM_004541579.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4G1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016924"/>
    <dbReference type="Ensembl" id="ENSMZET00005017464.1">
        <property type="protein sequence ID" value="ENSMZEP00005016924.1"/>
        <property type="gene ID" value="ENSMZEG00005012695.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003568"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001272">
        <property type="entry name" value="SMG9 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039177">
        <property type="entry name" value="SMG9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14270:SF0">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR SMG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="507" mass="56601" checksum="A2CA92367CFFB7D7" modified="2019-02-13" version="1">MSESGHSQPGMYGQGRRRRRRRGDRDVGPPGQNLSGPSRDRDYQPRERRDGSEDPPGPLIQKTPIILAKPPGERAKPSQNTPVSGTPVLEKPIMLMKARDDGVKPGTPTESAAQSSGPPSKIEREGQRPTQPVYQIQNRGMSASASSSALDPMVGQSKLLPPEKMKHSIKLVDDQMNWCDSAMEYLRDQTDMLVVGVIGLQGTGKSTIMSLLSANTPEEDQRSFVFRPQTQEIKERGGNQSTGIDFFITQERVIFLDTQPMLSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLNLYRFLQTAEMLKPSTPSASHDSTGSSGSDDGAEYYPHIVFLQNKARRDDFCPRNLKNMHMVVNKLMAHSHLKYKGTLSMLDCNVFPGLGQDYLTTEVNMFLLPVQENDGEDNLTKAGSGTYPLFSLLPGYRGHPAFSTMVSKLCSQTPAMPRCQLSHTILTEKNWFHYAARIWDGVKKSSALSEYSRLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4J9</accession>
    <name>A0A3P9C4J9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urokinase plasminogen activator surface receptor-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_014267561.2">
        <property type="nucleotide sequence ID" value="XM_014412075.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4J9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016964"/>
    <dbReference type="Ensembl" id="ENSMZET00005017504.1">
        <property type="protein sequence ID" value="ENSMZEP00005016964.1"/>
        <property type="gene ID" value="ENSMZEG00005012740.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:106676113"/>
    <dbReference type="GeneTree" id="ENSGT00940000163304"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050918">
        <property type="entry name" value="CNF-like_PLA2_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914">
        <property type="entry name" value="LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914:SF26">
        <property type="entry name" value="PHOSPHOLIPASE A2 INHIBITOR CNF-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018338146" evidence="3">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="4">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="4">
        <location>
            <begin position="114"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="207" mass="21360" checksum="8C7B1FD756630628" modified="2019-02-13" version="1">MQNLVLILGIVLLPRACALKCYECIPDLSGSCAQTTKECPSNTQCGSVRVTSYAGGSKLVDIKAKSCAAAEECVQASINFGVSQTLLTSKCCTSDLCNSQDAPEGSISSPNGKKCFQCDGNDCTKTLNCNGDEDHCISTRVTSGGQKVTVKGCASKVVCSSTQSAQIAGIIGTEISCCQGDLCNSAISTTAGLLLFVTPLISLVLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6F7</accession>
    <name>A0A3P9C6F7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch like family member 17</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C6F7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017639"/>
    <dbReference type="Ensembl" id="ENSMZET00005018205.1">
        <property type="protein sequence ID" value="ENSMZEP00005017639.1"/>
        <property type="gene ID" value="ENSMZEG00005013244.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157635"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18456">
        <property type="entry name" value="BACK_KLHL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18246">
        <property type="entry name" value="BTB_POZ_KLHL17_actinfilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000029">
        <property type="entry name" value="Kelch-like family member 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF475">
        <property type="entry name" value="KELCH-LIKE PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="99"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="615" mass="67744" checksum="0F3DA87A57E3E90E" modified="2019-02-13" version="1">MGTVPCSGVPQGSCSVESNPRPSGHGPTTLPTELSLPPPPPFFFFFYKLKPTTATSGTMMEGGMQLLNRDGHSISHNSKRHYHDSFVSMNRMRQRGLLCDIVLHVSNKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLIQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDNLNVPSEEEVYRAVLSWVKHDIDGRRQHVPWLMKCVRLPLLRRDFLMSNVDTELLVRHHSECKDLLIEALKYHLMPEQRGVLSNSRTRPRRCEGASPVLFAVGGGSLFAIHGDCEAYDTRTDRWHMVASMSTRRARVGVAAIGNRLYAVGGCAFIYIRVALFSYDGTSDLATVESYDPITNSWQPEVSMGTRRSCLGVAVLHDGSLYAVGGYDSSSHLATVEKYDPQSNTWTAIANMLSRRSSAGVAVLDGMLYVAGGNDGTSCLNSVERFNPKTNTWEGVAAMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRSNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7M3</accession>
    <name>A0A3P9C7M3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Striatin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26. Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538715.1">
        <property type="nucleotide sequence ID" value="XM_004538658.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7M3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018268"/>
    <dbReference type="Ensembl" id="ENSMZET00005018859.1">
        <property type="protein sequence ID" value="ENSMZEP00005018268.1"/>
        <property type="gene ID" value="ENSMZEG00005013705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466655"/>
    <dbReference type="KEGG" id="mze:101466655"/>
    <dbReference type="CTD" id="6801"/>
    <dbReference type="GeneTree" id="ENSGT00950000183095"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070016">
        <property type="term" value="F:armadillo repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000001">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000079">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000211">
        <property type="entry name" value="striatin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000616">
        <property type="entry name" value="Striatin-3 isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF2">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="17">
        <location>
            <begin position="44"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="571"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="706"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="784" mass="86015" checksum="6F952979C358785F" modified="2019-02-13" version="1">MDEQAGPGVFFNTSGSSGLPGAGNVKAPQPGDGGGEAARAQYSIPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERRGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGEIRPPSYDSDDDNEAPSPPNSSHQLSWKQGRQLLRQYLQEVGYTDTILDVKSQRVRALLGLAGDTGDKPSDKKTEPMVNGTEPSSLKDSGMVSKPDVSDSATVLEAFKFIESAAAEFSDEDEDEDSEGRDKTILDLAAMVRKKHSSTPSSTTSDLSDDLDTEEALKGFDFLASPDELDGSPESRSGDDSGEWEKEEQSPLGEMAWDVDQGLIAQLKEQYRKERKGKKGVKRPNRSKLQDMLANLRDAEDLPSMQPAVTPPSRSSVPRLNEHEVGRPDDEAMTFLPSSGKSFILGRVDEAVSNELGLGELAGLTVANEAEGLMYDIANNKDALRKTWNPKFTLRSHFDSVRSLAFHPVEPVLVTASEDHTLKLWNLQKTAPAKKCAALDVEPIYTFRAHSGAVLCVTMSSSGEQCFSGGVDGTIQSWNTPNPNIDPYDSYEPSVLRGALCGHTDAVWGVVYSSAHRRLLSCSADGTVRLWSAADTSPSLAVFNERGELGVPTSVDLVSSEPAHMVTSFDTGHIGLFNMETQQLVLKLESAGPPEAPCKINKVLSHPTLPITITAQEDRHIQFFDNNTGKLIHAMVAHLDAVTSLAVDPNGLYLMSGSHDCSIRLWNMESKTCIQEFTAHRKKFEESIHDVAFHPTKCYIGSAGADALAKVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBP7</accession>
    <name>A0A3P9CBP7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012772701.1">
        <property type="nucleotide sequence ID" value="XM_012917247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBP7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019537"/>
    <dbReference type="Ensembl" id="ENSMZET00005020166.1">
        <property type="protein sequence ID" value="ENSMZEP00005019537.1"/>
        <property type="gene ID" value="ENSMZEG00005014667.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:105940769"/>
    <dbReference type="GeneTree" id="ENSGT00940000166014"/>
    <dbReference type="OrthoDB" id="8391568at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF2">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="197"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="681" mass="76968" checksum="FB33E4BD7B1CFAA0" modified="2019-02-13" version="1">MATARKGRELFTILETSADTESTAACDSQDSPLNLSADVKWFEIPYRKPDSDEEDELREEEEEEDGGGEGENGFTSTAAAAAAETADAASFIAGGGCNIILVTGSNGLKHDEEEYAEDCYYSTSTNCSDTTSNDSDIDFSDLEEEEERRSFFSFEDDLDEDCTSPDFWGEPDQVISIEPFSAVSGPQHSLGDDADTRDYFRILFPDSLFEHMVEQTNNYALYRQRRSGKSDPHWHPTDVREMKAYVGLNILMGINQLPDTGMYWASDIFIGNAGFKKTMTARRFEKLTQYLQLCDRESEPVRGERGYDGLFKIRPLLDVVENTMWDAYVPNRCLTIDKCAIVTKGRFSPTQYMSSKPLRKGLTVWMLCDSRSGYCHRAKIYVGRPSEDEAAACLGYRVVTSLVRGLEGQYHHLFMDSFFTSVPLLQRLLRDGQYACGPTQPGRKGYPEVLRPRNVGKLSQGEFYQCQRGNLVATVTRDAKVVSCLSTNSAPGIVGISPGRQQHEADRDGENDSIDSSGLSFGVPRPLPLLLYQENMRGVDLCDQLRECYQVGRPCKKWWRYFLWFYVNLCIVNAYIILRESRGGAPPAGFNGKQFTQRHFRVRLAQQLIGDYQGARGMERAARKRHADSPIEYGHRLERMSERSRRCRNCTNKGLRHESVFGCKICNVHLCRGGCFSEFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBT6</accession>
    <name>A0A3P9CBT6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tensin 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBT6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019469"/>
    <dbReference type="Ensembl" id="ENSMZET00005020097.1">
        <property type="protein sequence ID" value="ENSMZEP00005019469.1"/>
        <property type="gene ID" value="ENSMZEG00005014600.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155400"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
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            <end position="974"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCI2</accession>
    <name>A0A3P9CCI2_9CICH</name>
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        <recommendedName>
            <fullName evidence="6">Transcription factor SOX</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="High mobility group box domain"/>
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        <property type="entry name" value="SOX-12/11/4"/>
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    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF323">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOX-12/11/4a"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
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            <end position="118"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="376" mass="42238" checksum="366A90CFECD824DF" modified="2019-02-13" version="1">MGLHKEPTEARLTAGYREAAAPERSRTVGACAGSPSPQKPERRKTASGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKWLGKRWKMLTDNEKVPFIREAERLRLQHMADYPNYKYRPKKKPRTEGRSAGQYQERNDTPSHKTPAAAKKFPRAGKSVGGAVKAGSLPPQDQQTDSRHQRKPQDRDNPHQQLDPRCQQLNSRYQLKHQQPDPEYQLLNPRYQLSARQTDHRLRYVPSAITLSKRDYTDSEEEDNDDSSSSSSEEEEEEELFTRHSTPVHPASLSPASPSRSVCTSASSCCGEDLDDLPVEPSASGSLSLSLVDKDLDACGCTEGGSLGSHFEFPDYCTPELSEMIAADWSAPETLSLPNKHVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCN3</accession>
    <name>A0A3P9CCN3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">D(4) dopamine receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004565003.1">
        <property type="nucleotide sequence ID" value="XM_004564946.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CCN3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020065"/>
    <dbReference type="Ensembl" id="ENSMZET00005020712.1">
        <property type="protein sequence ID" value="ENSMZEP00005020065.1"/>
        <property type="gene ID" value="ENSMZEG00005015059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473075"/>
    <dbReference type="KEGG" id="mze:101473075"/>
    <dbReference type="CTD" id="503566"/>
    <dbReference type="GeneTree" id="ENSGT00940000160974"/>
    <dbReference type="OrthoDB" id="10010417at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007195">
        <property type="term" value="P:adenylate cyclase-inhibiting dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071875">
        <property type="term" value="P:adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051481">
        <property type="term" value="P:negative regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051967">
        <property type="term" value="P:negative regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060158">
        <property type="term" value="P:phospholipase C-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014059">
        <property type="term" value="P:regulation of dopamine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15308">
        <property type="entry name" value="7tmA_D4_dopamine_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000066">
        <property type="entry name" value="Dopamine receptor D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002185">
        <property type="entry name" value="Dopamine_D4_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000929">
        <property type="entry name" value="Dopamine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF145">
        <property type="entry name" value="DOPAMINE RECEPTOR D4 RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00569">
        <property type="entry name" value="DOPAMINED4R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00242">
        <property type="entry name" value="DOPAMINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="36"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="414" mass="45391" checksum="6D6CBFB633522A91" modified="2019-02-13" version="1">MDNVTPGALPGEPDLKEYNYLALVLGVPLILVIILGNVLVCLSVLTERSLKTATNYFIISLAVADLLLAVLVLPLYVYSEFLGGIWTLSTYICDALMTMDVMLCTASILNLCAISVDRYIAVVVPLKYNRNQFSVRQLALITATWVLSLGVASPVIFGLNQVPDRDPSVCKLEDDRFVVYSSVCSFFVPCPVMLFLYYWMFRGLRRWSGRSRSQAGRAGRQVFSLQLSSALRRAKATTAGSQEKVVYTAPPGLSPTSPSTVSMATPSVTPVMEEHQDGIAVVADSDPMTTQMDSLSDGDPTDRREGGSRRENGLKGSAAKKKGRRQSKTSRVSGRERKAMKVLPVVVGVFLACWTPFFVVHVTKVLCQSCNIGPTLISVVTWLGYVNSAVNPIIYTAFNAEFRNVFHKLLCCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CD44</accession>
    <name>A0A3P9CD44_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi-associated plant pathogenesis-related protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glioma pathogenesis-related protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homodimer. Interacts with CAV1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004541467.1">
        <property type="nucleotide sequence ID" value="XM_004541410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CD44"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020230"/>
    <dbReference type="Ensembl" id="ENSMZET00005020882.1">
        <property type="protein sequence ID" value="ENSMZEP00005020230.1"/>
        <property type="gene ID" value="ENSMZEG00005015177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465037"/>
    <dbReference type="KEGG" id="mze:101465037"/>
    <dbReference type="CTD" id="449805"/>
    <dbReference type="GeneTree" id="ENSGT00390000020276"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000015">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="11">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="156" mass="17201" checksum="F5D95E17270EBFC4" modified="2019-02-13" version="1">MGKSASKQFAEEVLRCHNDYRMKHQAPPLKLSSKLSKEAARYAESLASTRILKHSVESSRGSCGENLAWASYDQTGKDVADRWYDEVKQYNFNRPGFSSGTGHFTAMVWKSTKQLGVGKAIASDGSSFVVARYYPAGNITNQGHFENNVLPAKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CER8</accession>
    <name>A0A3P9CER8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">iodotyrosine deiodinase</fullName>
            <ecNumber evidence="3">1.21.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:57506"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59898"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:27459"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + chloride + NADP(+) = 3-chloro-L-tyrosine + NADPH</text>
            <dbReference type="Rhea" id="RHEA:70343"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:189422"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:70345"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH</text>
            <dbReference type="Rhea" id="RHEA:70347"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:189423"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:70349"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH</text>
            <dbReference type="Rhea" id="RHEA:27453"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59898"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:27455"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.21.1.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004542009.1">
        <property type="nucleotide sequence ID" value="XM_004541952.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CER8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020534"/>
    <dbReference type="Ensembl" id="ENSMZET00005021200.1">
        <property type="protein sequence ID" value="ENSMZEP00005020534.1"/>
        <property type="gene ID" value="ENSMZEG00005015400.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464367"/>
    <dbReference type="KEGG" id="mze:101464367"/>
    <dbReference type="CTD" id="389434"/>
    <dbReference type="GeneTree" id="ENSGT00390000004348"/>
    <dbReference type="OrthoDB" id="41362at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140616">
        <property type="term" value="F:iodotyrosine deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02144">
        <property type="entry name" value="iodotyrosine_dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000004">
        <property type="entry name" value="Iodotyrosine deiodinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017976144" description="iodotyrosine deiodinase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="13">
        <location>
            <begin position="111"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="301" mass="34053" checksum="7C2F9EC90F0250C7" modified="2019-02-13" version="1">MAFLSVFTPVLAVVLCLVIGFVLVKSWDTETTSTSPGKSKGATKGEKRPWVDQDLQDDTEITAKEDDGDADDDWGDSTEEENLTQLPYSPQRYPEETMLQRSKEFYTLMNQRRSVRFISPEPVPREVIDNVIHTAGTAPSGAHTEPWTFIVVSDPDIKHQIRLIVEEEEEMNYRQRMGEKWVQDLAKLRTNWIKEYLDVAPYLILIFKQTYGILPNGKKKTHYYNEISVSISCGILLAALQNAGLVTVTSTPLNCGPKLRLLLKRPANEKLLMLLPVGYPASDATVPDLKRKHLDDILVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGI4</accession>
    <name>A0A3P9CGI4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatase and actin regulator 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Binds PPP1CA and actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell projection</location>
            <location evidence="10">Lamellipodium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560018.2">
        <property type="nucleotide sequence ID" value="XM_004559961.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGI4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020971"/>
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        <property type="protein sequence ID" value="ENSMZEP00005020971.1"/>
        <property type="gene ID" value="ENSMZEG00005015719.1"/>
    </dbReference>
    <dbReference type="CTD" id="393643"/>
    <dbReference type="GeneTree" id="ENSGT00940000157582"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061386">
        <property type="term" value="P:closure of optic fissure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048484">
        <property type="term" value="P:enteric nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001045">
        <property type="term" value="P:negative regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF4">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="9">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="9">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="9">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="583"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="450"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="653"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="882" mass="98299" checksum="308F370A01B19894" modified="2019-02-13" version="1">MACCFKSHHHTSWTLSTPLQDDEAEQHHSTMVGEGGSTGDSTPPPKRKGKFSTLGKIFKPWKWRKKKSSEKFKETSEELERQMSTRRTRQELIEQGVLKEVPDSDGEAQNVKQSYVKNGHTLPVGGGGVISGVRSPCNQGQLPSDSDFRMNPAWLAQPDDRRGRCSPSDGDRRGALGSRGTGLHDDGRRSAGIGARAQGEGEWKSNMAWQGHIHGQMEESRHGGRLHPDDGQKRPGLQKAPSEDGRRSRPAEGDWKPTLPRHASAEEGRARRESDSHFAPDLDTLREPLPPKQVIMPPKWLVSSTPEPGSECPPRTPSNHPTSQFSSPSGVTSKPVRSVSSACSNTQQSSAAALTPTSQPAKQPPLPPPKPVNRGNAAMLVSALQGGENAQLPLYWSCWKRECDYDVYLSLPVYLCRRAGGLRSGDFTQATGGASLVPAKPSPPMPPKRTTPVTKRNTEDSASSHPIIPSPLSLEEHSSLPLGFQLPPPPPSPPLPTHIPPSPPRQHIQTHHLHHQHSYPHPLPQPIPMLFDPPSPTNESPQRPAPVPLHIMIQRALSSPGPAQPHPDGSQRAHTLLFETPLEYQGGGRPLPVSIQPLKLSEDDYSEEEEEEEDDEEEEEYDGEIPQPELEPRSRRCLVGDAGICVIPRGNGNDDDEEEDEEDEDEEGEHDMHGEDSDSDGPVPHKDEDSDEDEEDEPPMSALASRVKRKDTLALKLSSRPSAPDRDRFTQERSSRDDHPPGQTGLTWQSREQWEAIRTQIGTALTRRLSQRPTAEELEQRNILQPKNQADRQAEVREIKRRLTRKLSQRPTVAELQARKILRFHEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNDYKSTEMEVHEESRIYTRFHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHM7</accession>
    <name>A0A3P9CHM7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHM7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021356"/>
    <dbReference type="Ensembl" id="ENSMZET00005022061.1">
        <property type="protein sequence ID" value="ENSMZEP00005021356.1"/>
        <property type="gene ID" value="ENSMZEG00005015853.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155899"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000006">
        <property type="entry name" value="Dual specificity protein phosphatase CDC14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="162"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="235"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="391" mass="44815" checksum="EEA34FFDDC816555" modified="2019-02-13" version="1">ATLRVKPKNTANTHFFSTDEEFIYESFYADFGPLNLAMLYRYCWKLNKKLKSFTMSRKSLVHYTSYDQKKRANAAVLIGAYAVMYLKRSPEDAYRTLIAGNIIFEQDMSFNAHIKQICKTAFFHLRNISKALQHGFLDFERFSAEEYEHYEVTDSDTTRSLIETYDVTQLLLTLSPGYPLHTPEAYFSYFCQNDITTVVRLNRTLYDGRRFEDAGFEHHDLFFLDGTTPSDLIVRRFLHVCESTDGAVAVHCKAGLGRTGTLIGCYLMKHFRFTAAEAIAWIRVCRPGSIIGPQQNFLEEKQHSLWVQGDVHRSKQKLVQQRLSKQEAVSSLLSSMDDLSINTVLCKSYSLDEVSGNNCKEVSLTQGDELRALKGKRPPRSASSCSRYQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJI3</accession>
    <name>A0A3P9CJI3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SH3 domain-binding glutamic acid-rich-like protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Could act as a modulator of glutaredoxin biological activity. May play a role in cytoskeleton organization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564431.1">
        <property type="nucleotide sequence ID" value="XM_004564374.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJI3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022473"/>
    <dbReference type="Ensembl" id="ENSMZET00005023220.1">
        <property type="protein sequence ID" value="ENSMZEP00005022473.1"/>
        <property type="gene ID" value="ENSMZEG00005016840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471033"/>
    <dbReference type="KEGG" id="mze:101471033"/>
    <dbReference type="CTD" id="83442"/>
    <dbReference type="GeneTree" id="ENSGT00940000157260"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03030">
        <property type="entry name" value="GRX_SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF3">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="92" mass="10407" checksum="576DDBB56A671786" modified="2019-02-13" version="1">MGIKLYYTTVTASRTVKSQQAEVIRILESKSIQYELIDISVGGELRDEMRSKVGDPTAVPPQLFNEHQYCGNYEMFSEAVEADTVEQFLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKP0</accession>
    <name>A0A3P9CKP0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 35 member E1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TPT transporter family. SLC35E subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574435.1">
        <property type="nucleotide sequence ID" value="XM_004574378.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKP0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022619"/>
    <dbReference type="Ensembl" id="ENSMZET00005023368.1">
        <property type="protein sequence ID" value="ENSMZEP00005022619.1"/>
        <property type="gene ID" value="ENSMZEG00005016929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469378"/>
    <dbReference type="KEGG" id="mze:101469378"/>
    <dbReference type="CTD" id="79939"/>
    <dbReference type="GeneTree" id="ENSGT00940000159007"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="9">
        <location>
            <begin position="14"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="383" mass="42905" checksum="E9DAF9F872AE8216" modified="2019-02-13" version="1">MAAVQRTPVREGIRIVSLCVCWYTVSSGGNVVNKIILNGFPYPVTVSLFHIISIVVFLPPLLRAWGVPKTELPSRYYWWYILPLAFGKYFASVSAHFSIWKVPVSYAHTVKATMPIWVVLLSRIIMREKQTTKVYVSLIPIIGGVLLATVTELSFNMTGLISALAATLCFSLQNIFSKKVLRDTRVHHLRLLNILGFNAVIFMLPTWVLVDLSVFLVNGDLTDVSGSMSTIILLLISGFCNFAQNVIAFSILNIVSPLSYAVANATKRIMVISISLLMLRNPVSLTNVLGMMTAIVGVFLYNKAKYDANKEKKLLPGSKQDLMSFDNPALEKIQANGSVPFPHSPEQQQQQQQHSWNHVLTDHFQYSQQTYTTNYSSNHQYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CL83</accession>
    <name>A0A3P9CL83_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Extracellular matrix protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_024658167.1">
        <property type="nucleotide sequence ID" value="XM_024802399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CL83"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022809"/>
    <dbReference type="Ensembl" id="ENSMZET00005023561.1">
        <property type="protein sequence ID" value="ENSMZEP00005022809.1"/>
        <property type="gene ID" value="ENSMZEG00005017079.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159941"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070052">
        <property type="term" value="F:collagen V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000772">
        <property type="entry name" value="Extracellular matrix protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000130">
        <property type="entry name" value="extracellular matrix protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000284">
        <property type="entry name" value="extracellular matrix protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043184">
        <property type="entry name" value="ECM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46544:SF1">
        <property type="entry name" value="EXTRACELLULAR MATRIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46544">
        <property type="entry name" value="EXTRACELLULAR MATRIX PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018335180" evidence="4">
        <location>
            <begin position="24"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="98"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="872" mass="102226" checksum="812CA33141154661" modified="2019-02-13" version="1">MRWWLVVASLWLLVALTIPDAEARNRPRNQNGEILRVRRRRKDGQGFGRARTRPLKIRLVPGPSIPVVPVEGNALLLQPYKNIQEQHATYNVIPGKQGQCVYQGLTMFDQAVWSPKPCVTCLCTGGRVVCDESTCPEIHCHFPFTPAGECCPVCMEPEPDLSLDISGDSPVPNDPSDVVTPLTQEEIQKILWREAEQHREEEERVKKKEEARRKRRKQRKEQEEKQRKIAEEMRKQEEEALRLQEEKELEEWSRQVDEEQKRRQEEEEDRRQKEEAEREARERERKLEEERKKQEEMLREELLDLVEKEKERHEEENERYEEEIERHEEENERREEEIERREEEIERREEEIERREEEIERCEEEIERYEEEIERYEEEIERREEENERREEENERREEENERYEEEIERREEENERREEEKEEQEEEVWLRGDVFQMLPKEPEEPEEPDLLPAPIPRPPVATEEEQVETKETEEGEDREIIVVNRGGLPPGCDISDVTATCEDAKLTHFPPLAIPELKSLSLEGNSISRIPADAFNGIPNLEWINLKKNKLTSAGIDAKAFKGLKKLTRLYLDGNLLDVVPSDLPPTLQELKINENRLRGIDENSFQDLSSLVILELEGNLLSEGNVDPLAFAPLIQLSYLRLGRNHFRTVPQGLPKSLLELYLENNLIEEISETVFNQTSNLNIVSLRHNKLEETRIAPLAWINHRNLESIDLSYNKLYMVPSYLPRSLVHLVLLGNNIERIPGYVFAHMQPGLEYLYLSYNKLDGEGTEPESFFGAYHSLVELCLDHNQLVVVPSGINEMTNLHFLRLDNNMIRSIPDEAICDPNRSGDSTLVAVRLENNYIDPQKISPMAFSCVRSASSVVLKPQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMT4</accession>
    <name>A0A3P9CMT4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
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                <person name="Tan F.J."/>
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                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
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                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
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                <person name="Streelman J.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
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    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="110" mass="12067" checksum="F11F3AB43BAEB174" modified="2025-10-08" version="2">MSLTPSSTRKGPTSSSLMIPVAPCDQAVTEGQDVVMSVKARGQPKPMVYWLKDRVSVKTAGHFTVREMEDGTSEMRIGSAQRSDAGLYACRIINEYGSKQAECRLEVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3P9CN56_9CICH</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CN56"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023783"/>
    <dbReference type="Ensembl" id="ENSMZET00005024564.1">
        <property type="protein sequence ID" value="ENSMZEP00005023783.1"/>
        <property type="gene ID" value="ENSMZEG00005017789.1"/>
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    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
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        <property type="entry name" value="ENVELOPE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
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            <end position="25"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="513" mass="56514" checksum="D2C6DDD5A545F1CB" modified="2019-02-13" version="1">HTPSRKTTHTTRPSYNQRVTGQSQPPGKIIMGNKRGHKHRCLAWPRWKAHSTARGQTDSNGRGTWSGACGTCTNDEELSRLVAPLSKRHDKIHDTNKMSKDDLFQILTGISGATNNWLLLAEQAADKTASDCIVCMGARPTLRVVPAPVNSACLLHLMNNTKRGHCSYLENHFPKTQRSVSNKPPFFSSDVAVNNFTCINLTGNAVKLGSLNSSWCTEMTVMKPNFRPTARADLWWWCGNNKLYDGFPRDASGLCALITLILPVLVTPVDLSIKVHEVGLPSSSERRSKRSLIPGSAHNPTYIDAVGIPCGVPDEYKLRDQVKAGWASILWMVEINANVDRINYIHFNVQLLANYTRDGFEAVHAQLSATSLMAFQNRVATDFLLAERGGVCSLFGQECCTYIPNNTAPDGSLTKAITGLTALTVKMKEHSGVDTAMWDSWLNMFGKYKALVASILVSISVFVAILVTCGCCCIPCIRSLFQRLIVTALTPEDKDLARQMPLLANVHEEITQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPL0</accession>
    <name>A0A3P9CPL0_9CICH</name>
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        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
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                <person name="Galibert F."/>
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                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPL0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023974"/>
    <dbReference type="Ensembl" id="ENSMZET00005024761.1">
        <property type="protein sequence ID" value="ENSMZEP00005023974.1"/>
        <property type="gene ID" value="ENSMZEG00005017937.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11422:SF6">
        <property type="entry name" value="HEMICENTIN-1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11422">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="203" mass="22251" checksum="6E346B25885250E2" modified="2019-02-13" version="1">LHYIRTFLFSVLGSAELAQRSVVRQTNLEISSVRETDAGRFTCLADGTRREHTLSVFSVSVSVTPSADLLLGSEATLQCDVKGVIEGCEVKWRSPKVDSPEWSPTAQLKPVTSSHNGTWQCIITCGSNQLSEHLTITVQGNTQILEMKTPVFHCDQKKNKHVFSFPEPPPTTSTTTASLCSSKDSPKTTFAIVCSVLLSYFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQS1</accession>
    <name>A0A3P9CQS1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil-helix-coiled-coil-helix domain containing 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004572091.1">
        <property type="nucleotide sequence ID" value="XM_004572034.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQS1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024690"/>
    <dbReference type="Ensembl" id="ENSMZET00005025498.1">
        <property type="protein sequence ID" value="ENSMZEP00005024690.1"/>
        <property type="gene ID" value="ENSMZEG00005018448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470496"/>
    <dbReference type="KEGG" id="mze:101470496"/>
    <dbReference type="CTD" id="118487"/>
    <dbReference type="GeneTree" id="ENSGT00390000007683"/>
    <dbReference type="OrthoDB" id="5825849at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CHCH"/>
    </dbReference>
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        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033620">
        <property type="entry name" value="Ribosomal_mS37_met"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="2">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="122" mass="13453" checksum="CBFC1F29BCFFB0B9" modified="2019-02-13" version="1">MATQGGIVFQEKVSRLLRGQNGKPVLKPNRALVLKDAVANRKPKKGEASCITEMSVLMACWKQNNFVDTLCSNEINSFYMCVEKAQADAKNKAGQSNIQGGRLPPKQATALLKRYPNLCKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRA2</accession>
    <name>A0A3P9CRA2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ladybird homeobox 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004572117.1">
        <property type="nucleotide sequence ID" value="XM_004572060.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CRA2"/>
    <dbReference type="Ensembl" id="ENSMZET00005025370.1">
        <property type="protein sequence ID" value="ENSMZEP00005024567.1"/>
        <property type="gene ID" value="ENSMZEG00005018367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477635"/>
    <dbReference type="KEGG" id="mze:101477635"/>
    <dbReference type="CTD" id="564103"/>
    <dbReference type="GeneTree" id="ENSGT00940000164611"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000098">
        <property type="entry name" value="Transcription factor LBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051892">
        <property type="entry name" value="LBX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336">
        <property type="entry name" value="TRANSCRIPTION FACTOR LBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR LBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="274" mass="30065" checksum="9AE6EFA6DCD23EFE" modified="2019-02-13" version="1">MTSKGDSKRPAVLEGSSRSPLDQLQPPVNTNKPLTPFSIDDILNKPSVKRSYFLSGEKLPSACHGVSSRVLLSQTSPLCALEELASKTFEGLEVSVLQAAEGRDGLTLFGQRNTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQMAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAKAAGAVAFEKLSKLAELEKSAAAAGGMGEGTISGPGQTEQHQISSRFHTTDTLDPLHLLPPSPASTGDYRLTTKCCLDDEDEIDVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSM7</accession>
    <name>A0A3P9CSM7_9CICH</name>
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        <submittedName>
            <fullName evidence="6">DENN domain containing 1B</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004553820.2">
        <property type="nucleotide sequence ID" value="XM_004553763.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSM7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025084"/>
    <dbReference type="Ensembl" id="ENSMZET00005025902.1">
        <property type="protein sequence ID" value="ENSMZEP00005025084.1"/>
        <property type="gene ID" value="ENSMZEG00005018728.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155446"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.200:FF:000003">
        <property type="entry name" value="DENN domain containing 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000001">
        <property type="entry name" value="Putative DENN domain-containing protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF24">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="13"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="713"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="641"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="870" mass="95889" checksum="F93E5C8D5EAFD4D6" modified="2019-02-13" version="1">MDSRIKENPERTFDLVVQVACPTSENEDPTVLWSFPQDHTDQEVLQTIPKFCFPFDVERVSQSQVGQNFTFVLTDIDSKQRFGFCRLTQGCRVCICLLSYLPWFEIYYKLLNTLADYLSKQQKNDLNDVLNSLYDLPVPKPFTPVNLSVNEQLYIATGQVLRDRRSKEPHSYFIAPDINGLPTIPESRNLTEYFVAVDINNMLQLYASMLHERRIIITSSKLSTLTACVHGAAALLFPMYWQHIFIPVLPPHLLDYCCAPMPYFVGVHLSLLERVRSRSLEDVVILNVDTNTLESPFDDLHNLPSDVVSSLKSKLKKQSTATGSGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVSHRSSTMKNFLSMAVNLQLFKQFIDGRLAKLNAGRGFTDVFEEEITEGGFCGSNSRSYQQWMHTVKRGGALFNTAVSKAKVHAKKGIRDFRGILKARDDEEEGIVVYPGSPTSTKSLSPRRLQKMRRHNFSKSPMSMGPRELGYGLDDEELDNASKVSSEDSGDVPSYNEDSDDSYSLDLDIDSSQSGQMNLLEEILDSLTTTTMDQGRLSAAKSLDFFLSVDDLDYKAPTKPTPCSESRPADESSCSGGGDQGGWNTGQDDTVVHGKHLPPSPRRQPTKSSLKMSKKSAAVPAAPAASPPAQSADVSVPNPHQSDPDPLPTAWKPGDCFSYSPTLSHRVAPLRSSPTLAQTYSSSASASDPSCSPAPGVRARTISDPQSGSEPQQAKNQTASTYVLRRKVMSKETTRQYQQKALQRQESKEGMGSPSRTSHSAVQVPWEKEMSKEGLLGLGLCLGQGKGSGAPAAQDQGLLEEIDSTCCLGAVLHTSLQLSQVNNSHHQVQGKAADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUH8</accession>
    <name>A0A3P9CUH8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intraflagellar transport protein 88 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Tetratricopeptide repeat protein 10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Positively regulates primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT20, IFT22, IFT25, IFT27, IFT52, TRAF3IP1, IFT74, IFT80 and IFT81. Interacts with IFT172. Interacts with IFT57. Interacts with IFT46. Interacts with IFT70B. Interacts with C2CD3. Interacts with ENTR1 (via N-terminus). Interacts with LRRC56. Interacts with DZIP1. Interacts with CCDC38. Interacts with CCDC146. Interacts with CFAP53.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUH8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026025"/>
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        <property type="protein sequence ID" value="ENSMZEP00005026025.1"/>
        <property type="gene ID" value="ENSMZEG00005019395.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015473"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:non-motile cilium"/>
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        <property type="term" value="F:kinesin binding"/>
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        <property type="term" value="P:inner ear receptor cell stereocilium organization"/>
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        <property type="term" value="P:regulation of cilium assembly"/>
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        <property type="entry name" value="Intraflagellar transport 88 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000135">
        <property type="entry name" value="intraflagellar transport protein 88 homolog isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
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    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="464"/>
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        </location>
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    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="498"/>
            <end position="531"/>
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    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="532"/>
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    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="704"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004230"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="805" mass="91187" checksum="B19B7F1AE1DDD3B3" modified="2019-02-13" version="1">MEHVHLAVEEDDLYSGYNDYNPTFDSEELENDVGFQQAVRTSHGRRPPMTAKFPGTPIGPRSLASSFGARLHMASSMGRPMTGAVQDGSARPMTAVKAAGYTSSLSRGSAFDPLGQSRGPAPALEAKNEDTPEEKIKILEKKVNDLIEESCMAQSMGALQVALEKAKEAGRKERALVRQREQSGSADHINLDLTYSVLLNLANQYTNNEMYPEALNSYQIIVKNKMFSNAGRLKVNMANIYFKQKNYPKAIKFYRMALDQITNAHKEMRIKIMQNIGVVFICMGQYTDAITSFEHIMSESPNIKTGFNLILCYYAIGDRERMKKAFQKLISVPLGIDDEDKYIPSNEDTSSNMVIEAIKNDKLHQMERDLKTLAEKYIMTAAKLIAPAIETLFATGFDWFVTAVFFFASKDFNAVETLKAFEKKDSRVKSAAATNLSFLYFLEKDYDQADRYADLAMNADRYNPAALINKGNTVFVKQDYEKAAEFYKEALRNDSSCTEGLYNLGLTYQRLNRLEEALDCFLKLHAILRNSSQVMYQLASLYELLENPEQAIEWLMQVISVTPTDAQALAKLGELHDGEGDKSQAFQYYYESFRYFPSNIHVIEWLGAYYIETQFCEKAIQYFERATLIQPTQVKWQLMVASCYRRSGNSQKALETYKEIHRKFPENVECLRFLVRLCTDMQLKEAQDYATKLKKVEKMKEIREQRIKSGREGSARSRREGRESSAGSADSGRSSSSTKGERLSAKMRSLPGSNEPYEASSPKELDASYVDPLGPQMDRPKTGVKKRVEDDDFADEELGDDLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVK3</accession>
    <name>A0A3P9CVK3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease P/MRP 40 subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004572443.1"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005026109"/>
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        <property type="protein sequence ID" value="ENSMZEP00005026109.1"/>
        <property type="gene ID" value="ENSMZEG00005019475.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101481437"/>
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        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="350" mass="39298" checksum="2624E59A638C96D8" modified="2019-02-13" version="1">MTSSELDRTPRTLLVSESSSFLDPKNRISAQVQQLHFNHQVSVLLPECSSAPSHLDSVLNNFSSFYLIRKLPVYELLDRHFLETAVYHGAVFGLSYRTRIDEDTCVALMPNGHLTLSLDKDSFEILGFEGKPSRFKHRTATRFVVSVDLTDSSMAPGRRSYLRLLTGLKSRLQLQTDFLLSHHPGGGASLQPLLSRCDWSQHRPEVNCSVLTDLSCPAPRSCDPHSFLEWLGAVDAGISCENSSSSFLSSFVCPEPNTIHRHALSVSVSGMLLPHDIHRLLQELRRYVEQPRLASWVSMTVRGFADSPVSWSNHEHGFLRGGENFYTLMMFHDHTYQLHLATGAHDVCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CWK6</accession>
    <name>A0A3P9CWK6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WAP four-disulfide core domain 2</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CWK6"/>
    <dbReference type="Ensembl" id="ENSMZET00005027580.1">
        <property type="protein sequence ID" value="ENSMZEP00005026723.1"/>
        <property type="gene ID" value="ENSMZEG00005019928.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165527"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Elafin-like_sf"/>
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        <property type="entry name" value="WAP_dom"/>
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    <dbReference type="InterPro" id="IPR050514">
        <property type="entry name" value="WAP_four-disulfide_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441:SF95">
        <property type="entry name" value="PERLWAPIN ISOFORM X1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19441">
        <property type="entry name" value="WHEY ACDIC PROTEIN WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00003">
        <property type="entry name" value="4DISULPHCORE"/>
    </dbReference>
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        <property type="entry name" value="WAP"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018225861" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="2">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="124" mass="13456" checksum="214D19313F29A5B0" modified="2019-02-13" version="1">MDKHWWTICALVLAFCALAHFDTVLSASACCKITVKPGVCPRRRLGYGRCAEFCSNDSDCPDKEKCCSNGCGHECMAPYVVKPGGCPLPETTPMCAEYCYHDGQCPGDQKCCRTTCGHACSEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYL0</accession>
    <name>A0A3P9CYL0_9CICH</name>
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        <submittedName>
            <fullName evidence="7">AF4/FMR2 family member 1</fullName>
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    </protein>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AF4 family.</text>
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        <property type="gene ID" value="ENSMZEG00005020442.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AF4/FMR2_CHD"/>
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        <property type="entry name" value="AF4_int"/>
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    <dbReference type="PANTHER" id="PTHR10528">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10528:SF6">
        <property type="entry name" value="AF4_FMR2 FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05110">
        <property type="entry name" value="AF-4"/>
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    <dbReference type="Pfam" id="PF18875">
        <property type="entry name" value="AF4_int"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="1127"/>
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            <end position="577"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="683"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="1005"/>
            <end position="1040"/>
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            <end position="32"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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    </feature>
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        </location>
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    </feature>
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        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1135" mass="124372" checksum="ECA6EC32102B9CD3" modified="2019-02-13" version="1">MTSQPSAHDGERHLLRLRAWQQRVQEASQTQEPKPENVPLFGEPYKTNKGDELSNRIQRMLGNYEDVDTPSPLSIEMIPTPAYANLSQSDQGQLNTDKSTKPPIQNQVLSMSTQSQKEPSSNSLHPMRGVTTTSPTHHGHSSTFSKPPLNHSQGSQLNHSAHHQQQQKKNEVFSDLRDRASLYHEMSDQSDDVKPLPFLHSSDHNHMDTDTKDTVDEYQGSTDHASESSSNVDVSILKIKQSPKDVSLPEANKTNALPSQTFPLLLSSKQPSVVMTQKPTAYVRPMDGQDQLVTESPELKPSPEPYAPLPELIGKSDLGKTKKAPQFLETKTDEAQCVEDILREMAHAWPPLLKTICTPSTDEPPKSPFLAKEAKHASSCPGQRNHDSSPPESSHPSQQMSSSSFEGAHSSGVESMSSSESESSSGSDSESENSTVEPPQPPAGTSIKTAADAPAVSHEDWQLGNWIRSSQPNSGSESQSAVLVPENTSHKEQQFTQDFKHSSVQVVDSTGESQPQLSSHHTDSTAVSQQSSESSQDNCCLQSRQKSLSANVNSSKKFSKSVKGGCPDRTDAATPVKCEEAVTAQTKYPCFTDRPKVKTKVGHCKKSKEGSNGKRDIKRTKLSSQHFPNSCPAQSPVQPAPPVSISCSKSNTETISQTGTKMPHKTTHKHLKKPGRIAKASLDLERTPRSLMVKIELSLLSRVPQTSGIHQGIPSTAKKSAPVTDPDKVGGGTSATHSHTKTSRKSKPQNAEVDNKGLPRKKQKLENKNASLTKVSVKLKCSSSLAEAQQRKKAKKDCQHPEPSEDAAKKSKLHKSQVKTQESSKKTEKKKVSHKHKKSNGKSTEHPKSETNKSPKVSFAVTSSSQPLSEAVANRSLLKFEEKQHPVKHYIKEAKRLKHKADAESDKLSKAFNYLDAAMFFVESGIAMEKDPQTLLSSYTMFAETVELLKFVLKLKNSVDLSAPPPEKDFLVLCLKCQSLLQMAMFRHKHKAALKYSKTLTEHFSSSAQATHNPQTSRVGDNLSTCLPSPATTSGPSSNHSASGLVVGSTVAVPQAIEQMTFTYVNITSLFLSAHDIWEQAEELARKGSGMLAELDTVMGPLNLSSDMTSMVRYTRQGVYWLRLDSQKYRCGCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1K9</accession>
    <name>A0A3P9D1K9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ajuba LIM protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012771512.1">
        <property type="nucleotide sequence ID" value="XM_012916058.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012771513.1">
        <property type="nucleotide sequence ID" value="XM_012916059.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1K9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028087"/>
    <dbReference type="Ensembl" id="ENSMZET00005028982.1">
        <property type="protein sequence ID" value="ENSMZEP00005028087.1"/>
        <property type="gene ID" value="ENSMZEG00005020956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486787"/>
    <dbReference type="KEGG" id="mze:101486787"/>
    <dbReference type="CTD" id="84962"/>
    <dbReference type="GeneTree" id="ENSGT00940000160978"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09352">
        <property type="entry name" value="LIM1_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09355">
        <property type="entry name" value="LIM2_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09438">
        <property type="entry name" value="LIM3_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000037">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047245">
        <property type="entry name" value="Ajuba-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047247">
        <property type="entry name" value="Ajuba-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047248">
        <property type="entry name" value="Ajuba-like_LIM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF8">
        <property type="entry name" value="AJUBA LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="527"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="592"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="653"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="731" mass="77025" checksum="C3F7BEE7EB67269C" modified="2019-02-13" version="1">MDRPISKLLEKLKLTDSGSVKFNVSKKKHDSSSNSNNSNANTGVPVGGSGGGGSVLPLAPSSAAASPARPGQFPLASATTSDPCVPASGRGGGGGTGGAGGMGLTSSQLLTTPSTSSTVGTIPPDVEQPPHPSTLAPLRRPSSQQRASCYLGEGVDSHLRRESGLSPECDPMGAFGSKVSLNQRRYSLELQQLVQRQQLLSQPPPLSVPPPYPAASGYGSAPRGGGGGLAEPGYLSEPERHKRLSLQETLFYKRLSTGNDLWESTRPASLSHPPHRPSDMSGGGVGGGGLFYPPGPTLSPCSSFSFQESVLVSPRSSFASSTASGGGGGSPMGSRCSSNRTSGISLGYDLRYSASGGLPTQQQSPSVPTGGSATGYGVPGRAGVTSVEAWTQYLEAGIRSGVYDSRHSYPPAVGSPAATCYQTAPDWWEEQQAGIRGKDPGTMGERARYSDLPGTRYQEELTRLLLRDAALEGDGLLEGLMLKEQALSLTPHAKSGVTPAGGLAKPQEEPGALPGREATENRQEFFGTCVKCGKGVYGADNACQALENLYHTRCFTCVSCGRTLRNKDFYNVNGSVYCKEDYMFSGFQAAAEKCSVCGHLILEQILQALGNSYHPGCFRCVVCSKALDGVPFTVDQHSKIYCVADYNKTFAPKCAACLQPILPTEGSEDILRVVSMNKDYHFECYHCEECGKQLSDKPGSQCFPLDSHLLCHSCHVNRVCATHNVPPHNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2R2</accession>
    <name>A0A3P9D2R2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D2R2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028391"/>
    <dbReference type="Ensembl" id="ENSMZET00005029295.1">
        <property type="protein sequence ID" value="ENSMZEP00005028391.1"/>
        <property type="gene ID" value="ENSMZEG00005021168.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159445"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000014">
        <property type="entry name" value="adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF6">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="133"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="391" mass="43737" checksum="8A3D7BF1F8B53B8F" modified="2019-02-13" version="1">MVGIGTSVSHVIIISVYVPVTRPETPDLAVQLVANAVLFACVNAVGVFHLYRTEKDLRISNQKREEFSAIRSQKEIKKYQQEQLLLSVLPRYIAVELKTEVISRLSNPKSDDENKSTSNNFHSLYVRQHRDVSILYADIVGFTKLASTCTPEELVAVLNKLFGRFDDIAKRNGCLRIKILGDCYYCVSGLPDPIPTHAKNCVKMGLDMCTAISNLREATGVQINMRVGVHTGNVLCGVIGLQKWQYDVWSDDVTLANHMESGGLPGRVHITEETLQHLDGAYEVEDGDGGSRDHLLKGRKTYLVIDPKKPHRPPRRHGLPSHLTPGENRQRASLRMSQYLQSWKSVNPFEGLSNPEARRPKKSTTERPVSQDDCLVIDNSVRGSLDTLDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D459</accession>
    <name>A0A3P9D459_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GRAM domain containing 1C</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004546769.1">
        <property type="nucleotide sequence ID" value="XM_004546712.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023011249.1">
        <property type="nucleotide sequence ID" value="XM_023155481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D459"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029420"/>
    <dbReference type="Ensembl" id="ENSMZET00005030348.1">
        <property type="protein sequence ID" value="ENSMZEP00005029420.1"/>
        <property type="gene ID" value="ENSMZEG00005021950.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464768"/>
    <dbReference type="KEGG" id="mze:101464768"/>
    <dbReference type="CTD" id="54762"/>
    <dbReference type="GeneTree" id="ENSGT00940000158013"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF1">
        <property type="entry name" value="PROTEIN ASTER-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="321"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="657" mass="75436" checksum="5511F18A9AA9037D" modified="2019-02-13" version="1">MDQVSNRSGVGSDDITDDTSLPDLRWSSDEDSSDVQTQCLAAPQPPVPTYKQRLEEFKKLFKELPETERLLVDYPCALQRDILLQGRIYLSVNWVCFYSNVFRGTKITLTLKNITNMTREKTARFIPNAIQICTSTDKFFFTSFSAREKSYREFSRMWENTLLGKSLTSHELWQTVRQHYGFDLGLSYEEMDSSPIIAESNMQTSLTARPGGDDGPGRLERPPFLRIPEVENGPLDTSTPQGEEMPSPIGSQSSSNLEDFRNTPSQRRSPAPQLDRLVPERVSKRSSLSLDLNANENGMSEESGSESEEEVEDRVGLSQVSGRQYLNRVFHIGAKHMFGILFTDSTFMRRFMDARKITNITSTAWQKDSSGNMKRSLNYTITINNPLIGKFSTATEYQTLYKESRDGQYYLINSEVYTHDVPYHDYFYTQTRYYIMSNSKRKCRLRVYTDVKYKKQPWGLVKSFITKNSWSGIEENFRHLEAELLEEEAEMNQGGGEAGKMGGLRRRRRTYSRTLAEHSKPKKQYRHHAEQHREGNMGPVDMKGPYRWNVTTIVAGMSVVLLILTMLNLGLFFKLWAMEDVAQRMYLTTKHRLRERSEASLAAEYGSKLGAALRSPEELRLLKNVLQDSINLLEQLRTSLVMLQQNFATANHTAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D471</accession>
    <name>A0A3P9D471_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D471"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029149"/>
    <dbReference type="Ensembl" id="ENSMZET00005030067.1">
        <property type="protein sequence ID" value="ENSMZEP00005029149.1"/>
        <property type="gene ID" value="ENSMZEG00005021723.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164100"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF170">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="28"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="320" mass="36584" checksum="7BC66519B06ABD20" modified="2019-02-13" version="1">MLVKPRLIKLKGNPSQKTESFDNPNHSPDALRIVMIGKTGCGKSATGNTILGQKCFYSKTCMKSVTEVCKKAKGVVDGHPVAVVDTPGLYDTTLSNHEVKQELVKCISLLSPGPHAFLLVVQIGRFTKEEKDTVELIKEFFGKKSEDFIIVIFTRGDDLQDQTIESYMEEVSDDFVKKLIDDCGGRYHVFNNRDQNNHSQVAELLDKVQTMVKKNGGSCYTTEMFQEAEAAIQKEMKRILKEKEADMEKEMEELQRKRDEEIQAKKKQIDQERAEKEELHILDKNQLMFLSLILMITLSPKIILIQYGTMNKYYCWEISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D593</accession>
    <name>A0A3P9D593_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D593"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029743"/>
    <dbReference type="Ensembl" id="ENSMZET00005030678.1">
        <property type="protein sequence ID" value="ENSMZEP00005029743.1"/>
        <property type="gene ID" value="ENSMZEG00005022184.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006705"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045698">
        <property type="entry name" value="Rab3GAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19533">
        <property type="entry name" value="Rab3-GAP_cat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="12">
        <location>
            <begin position="297"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP catalytic subunit C-terminal" evidence="13">
        <location>
            <begin position="450"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP catalytic subunit C-terminal" evidence="13">
        <location>
            <begin position="529"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="631" mass="70406" checksum="9D26D4A968CE9F65" modified="2019-02-13" version="1">RYTDKDNTVPGLERQLQFEAHVLLTFGVCVNDPMENVSETLLYCLLCLSPNSDLDPLQAPHWSVRVRTAENPQCLLGQIKCLFFLIVLCVGLLLPPCGSLTRTDVAPLLLVTNSFSFLVTVEPVTLSSSKCIKFGVLLFDFMLVFSLVVEAFPPAEVSPSDSLTYRLALCVCLVNYYYGGLRARWENNHLICGLAGGAPDLRCCLLHQKFQMLNCCIERKKARDESHKVPEGKEKEHRVLGACQKSRQGPECATSASSSTREMSQGKSWDSWSDSEEEFFECLSDQGETEATQAEGRAEGRLHPYNNMTLLNSAEPLYVHRSESLPHCANTSYAVIYSKYTHCSFINHLQSLCLCPQAANPGCVLEDFVRWYSPRDYVEEEVVDEKVNTMVMGTLSPRMKIPGNMWVEAWETARVTPARRQKRLFDDTKEAEKVLHYMAMQKPADLARHLLPCILHATILKEEESAEDIPSVQKTIQQATVQASKLLQSPNQDYKKLEVILVSSGFTCSYLSVLFCGNIVTFSTLCVVSRFVSSLLEEPEVVVTGAGQGLAGSIIHGLFISAQRVTLTLPPCPSHVLVPDFPPPAGREILLRTCVPRPAAYSKALPQRLFCVLMREEFRLTGAFSTDTSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D683</accession>
    <name>A0A3P9D683_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012777080.1">
        <property type="nucleotide sequence ID" value="XM_012921626.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D683"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029849"/>
    <dbReference type="Ensembl" id="ENSMZET00005030789.1">
        <property type="protein sequence ID" value="ENSMZEP00005029849.1"/>
        <property type="gene ID" value="ENSMZEG00005022265.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476646"/>
    <dbReference type="CTD" id="26191"/>
    <dbReference type="GeneTree" id="ENSGT00940000167346"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050868">
        <property type="term" value="P:negative regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047170">
        <property type="entry name" value="PTN12/18/22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983">
        <property type="entry name" value="TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="208"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="741"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="777"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="834" mass="93665" checksum="C1BE81405A308660" modified="2019-02-13" version="1">MDQQVRILRSFLDDLERQEAAAEETPNGIAGEFVRLKSQSTKYRTDKTYPSKTAEKQENIKKNRYKDILPFDHTRVKLTLVTSKNDTDYINASFLKGVSNSRAYIATQGPLPHTVVDFLRMLWEYKIEVVVMACREFEMGKKKCEVYWPQKHEEPFVCEPFKVYCDSEESKGDYLTRTLRLTYHNSSRTLKQLHYVNWPDHGVPDSIPPILDMLHEMRSYQAHDDVPICIHCSAGCGRTGALCVIDYTWNLLKKQMITSDFSIYNLVQSMRTQRPSLVQTKEQYDLVYRTIKLLFQRYLQSVDEQTFQNEVSEIFIPGEESGFLPQFQHLLDEERAFLPQYNSPLASSENLLFLNAKDMHKDQQQWPLFQTSPESVPQDLNEVPWMVHANQRIPSAEEELVAESDSVPSLIRQPSPDLAAAICSMVEDPYFDTGLSSPSSDGGHTGAAEETTEWTFSPLFSAPSLFLNDHTLEANSPASDTGEVCTSGEDPPPLPERTPESYMLAVDTEVSDPFERLLVIPHDAAADALPEISGSPPSPAPPLPERTPESFELAIDQAPVEQKLEVIPAVAPAVNLNVIGMSSEWFGNSNLGATTFQNERKSFERSKSLKVKMTFTGPVNDPDLSSNCTYSPSVEPLSPPQPAKAERSLTPPLPERTRQSFILATEEILEPTAIFPQPLEIAHPSTRVGISSEWDGTSQPKNFHDAVMSRSKSVRPKSSRQEPPTVVQPIAPPTVFVAEGGSAQAEHCDVNRRASLNNEKSENKSDKNSEKAMSRTKSLRFFKHKQRPKTAPPMPPTQPGASSQPCSVFSVFKFGFGNRFGKPKGPRKYPDTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D708</accession>
    <name>A0A3P9D708_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Sodium/potassium/calcium exchanger 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Na(+)/K(+)/Ca(2+)-exchange protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Retinal rod Na-Ca+K exchanger</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Solute carrier family 24 member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D708"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030353"/>
    <dbReference type="Ensembl" id="ENSMZET00005031306.1">
        <property type="protein sequence ID" value="ENSMZEP00005030353.1"/>
        <property type="gene ID" value="ENSMZEG00005022618.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234532"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060292">
        <property type="term" value="P:long-term synaptic depression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060291">
        <property type="term" value="P:long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000002">
        <property type="entry name" value="Sodium/potassium/calcium exchanger 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000004">
        <property type="entry name" value="Sodium/potassium/calcium exchanger 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF36">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0769">Symport</keyword>
    <keyword evidence="9 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="26">
        <location>
            <begin position="137"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="26">
        <location>
            <begin position="528"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="401"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="402"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040585"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042297"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045976"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="689" mass="76956" checksum="833FB919080A961F" modified="2019-02-13" version="1">TPTRSPPTIRLSRVLFLLSGVFLCTLYQLTISTRLYEPLAMPQIIQRNTMYDVHNATTTSVSTTSTTTESPLLPTTNRTLVHCIYVAPELPETPTPAPPTTTVPPAFPGEAPHMKGDYPEDIFSIEDRRRGWVTLHIIGMMYMFVSLAIVCDEFFVPALGVITNKLAISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILHLTWWPLFRDVSFYILGLIFLIIFFLDNVIMWWESMMLVACYTVYVIFMKFNVQIERAFKTQLHKHKSIVKVIAVEEPDKVRSPIKEFIKDNAPPAPEDKNLTSYHDLSRLFPQLKPSLQRGGSSASLHNSTMRNTIFQLMIHTLDPIGNGEYYLIVVNTLLSKLFGIPFTDGGEKTEQSKESEPTPAAEEEKKEQPEDKKVLSNHEDVPAKDDGSGESDDSESDEEDSDDESDESSEDEDDDEDKDEEEEEKDDEPLSLEWPDTRRKQATYLFLLPIVFPLWLTVPDVRNPKSRKFFVVTFLGSILWIAIFSYLMVWWAHQVGETIGISEEIMGLTMLAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLYSAIHSFGPVAVSSNGLFCAIVLLFLMLLFVIISIASCNWKMNKVLGFTMFLLYFIFLVLSVMLEDRIIICPVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7H0</accession>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
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                <person name="Gnerre S."/>
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                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
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                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
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                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
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                <person name="Renn S.C.P."/>
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                <person name="Ron M."/>
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                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <authorList>
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    <sequence length="70" mass="7757" checksum="C93853F145DCC6E4" modified="2019-02-13" version="1">MDELHAPGDTMEVDFNDNMSTSALNMDNMDWLDLTLSVPAEEGHSLDVSVPVGVFSSDFLDSSELHLNWD</sequence>
</entry>
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                <person name="Malinsky M."/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="PB1-like"/>
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        <property type="entry name" value="PB1_dom"/>
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        <property type="entry name" value="PB1_MEKK2/3"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Pkinase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    <dbReference type="PROSITE" id="PS50011">
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
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        <location>
            <begin position="44"/>
            <end position="123"/>
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    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="353"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="224"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="617" mass="69531" checksum="B6A1D51FDF1CE3BE" modified="2019-02-13" version="1">MNERQALHSIMKDLVALQMTRRQPVLSHDSGKPKTPAQANRQDDVRIKFEFSGERRILVFGRPVQFEEIQQKVKTVFGQQLDLHYMNNELSIPLRGQDDLDKAIDLLDRSSNMKSIRILLLTQEHSNASSPSHHVPCKQVRIKSSHSTGDVSTVYQSSEPRGRHLSTGSQNTGRSSPPPGYVPERQQRIARQGSYTSINSEGEFIPETSDQCVLDPWSSAENSISGSCQSLDSNSDSPSLRKSRMHRAKSYPDNRQECSDRENHVYDRVAGKGGTFPRRYLVSLPYKDNSEGRRTFPRIRRPQGNLFTLVPSRRSLNGSEESLGSWQQVDAQGRLRPQDRSVPHKSPSAPVTWRRGKLLGQGAFGQVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPLLPSHTSDQARDFIRSIFVEAKHRPSAEELLRHPFSQILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCT6</accession>
    <name>A0A3P9DCT6_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Si:ch211-243a20.3</fullName>
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        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCT6"/>
    <dbReference type="Ensembl" id="ENSMZET00005033001.1">
        <property type="protein sequence ID" value="ENSMZEP00005031967.1"/>
        <property type="gene ID" value="ENSMZEG00005023842.1"/>
    </dbReference>
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        <property type="component" value="LG6"/>
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        <property type="entry name" value="HEME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SI:CH211-243A20.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018064307" evidence="1">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="190" mass="21466" checksum="885638957DB68C9B" modified="2019-02-13" version="1">MGPHSLLMALMVVATATGAYAAEEENEVDYGYWNYREGAESVNVASVRSVTRVLDAWGKRIFSEIKTLLHSQPSTLLPDYSRVRPLSESVNDLFREVSLLHRRIAELSHRLATLEPFLRRYGYQGEDGEDEEEEAEGRRAHSLKGKVASLARYTPRSAVSVSPPRGSRVVRRRRVRVLKNRGVKLVKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DD89</accession>
    <name>A0A3P9DD89_9CICH</name>
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        <submittedName>
            <fullName evidence="9">Arylsulfatase family member J</fullName>
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        <name type="common">zebra mbuna</name>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004575833.2"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005032473"/>
    <dbReference type="Ensembl" id="ENSMZET00005033525.1">
        <property type="protein sequence ID" value="ENSMZEP00005032473.1"/>
        <property type="gene ID" value="ENSMZEG00005024189.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159954"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000002">
        <property type="entry name" value="Arylsulfatase family member J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arylsulfatase family, member J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF69">
        <property type="entry name" value="ARYLSULFATASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018263971" evidence="7">
        <location>
            <begin position="22"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="566" mass="65072" checksum="169542A2D9B11606" modified="2019-02-13" version="1">MFILWVPLSLFFGCIISQTWSVQMSWENWNAELHNQGNEFGKSSSQPHIIFILVDDQGFRDVGYHGSEIKTPTLDRLAAEGVKLENYYVQPLCSPSRSQLMTGRYQIHTGLQHSVIRAAQPNCLPLENITLPQKLKNAGYSTHMVGKWHLGFYKRGCLPTQRGFDTFFGSLLGSGDYYSHYKCQGPSMCGYDLYEGEEAAWEQDRGLYSTVMFTQKAVSILANHNPRKQPLFLYLAYQAVHSPLQVPARYLERYKGIPNPYRRKYAAMVSCLDEAIHNLTLALKHYGYYDNTVIVYSSDNGGQPLAGGSNWPLRGSKATYWEGGIKAVGFVHSPLLMNKGTKCRSLIHITDWFPTLVTLGEGTLDEDLNLDGYDVWETISEGRPSPRHDILHNIDPIYIKAKNGSWKAGYGLWNTAIQAALRVGHWKLLTGVPGYSDWVPPQTFLNQRLTTRLHNERVRWDRGKSIWLFNITADPYERVDLSQRYPHIVKKMLMRLAQYNKTAVPVCYPTKDLRSNPQYNGGVWGPWHKDMREQQEEDEMYNNLFTNHLSKKRWEKKSKNTKLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFE5</accession>
    <name>A0A3P9DFE5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFE5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033203"/>
    <dbReference type="Ensembl" id="ENSMZET00005034326.1">
        <property type="protein sequence ID" value="ENSMZEP00005033203.1"/>
        <property type="gene ID" value="ENSMZEG00005024783.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164025"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01385">
        <property type="entry name" value="CLAUDIN14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="200" mass="21793" checksum="0F3922D1660FAD68" modified="2019-02-13" version="1">MLSELLGLVLAIIGFLGSIITCVLPMWRVTAFIGTNIVTAQAIHEGLWMSCVVQSTSQKQCKVYDSKLALSQDLQAARALIIIAILLGFFGILFAVVGYRCSNCIMHQRQNSNVTIASAVIVIIAGVLLLIPVTWTAHAMIKDFYNPLWSASQKRELGSSLYIGWGSAGLLFLGGGLLCSSRPRMNDTDCEVRYSNHRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFT4</accession>
    <name>A0A3P9DFT4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine and arginine rich splicing factor 7a</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012771134.1">
        <property type="nucleotide sequence ID" value="XM_012915680.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFT4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033032"/>
    <dbReference type="Ensembl" id="ENSMZET00005034123.1">
        <property type="protein sequence ID" value="ENSMZEP00005033032.1"/>
        <property type="gene ID" value="ENSMZEG00005024627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466619"/>
    <dbReference type="CTD" id="402972"/>
    <dbReference type="GeneTree" id="ENSGT00910000144115"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12646">
        <property type="entry name" value="RRM_SRSF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000126">
        <property type="entry name" value="Serine and arginine-rich-splicing factor 7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000078">
        <property type="entry name" value="serine/arginine-rich splicing factor 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034651">
        <property type="entry name" value="SRSF7_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF3">
        <property type="entry name" value="SPLICING FACTOR, ARGININE_SERINE-RICH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="254" mass="28858" checksum="CDB4D642A6126910" modified="2019-02-13" version="1">MSYYSSSRSSSRATDCKVYVGDLGNGAAKGELERAFSYYGPLRSVWVARNPPGFAFVEFEDPRDAEDAVKGMDGKILCGSRVRVEMSTGLSRKGRGRPSRRQFDPNDRCYQCGDRGHYAYDCYRFSKRGRRSRSRSRSRSRSRSRSRGRRYRSRSRSRSRSRSRRRSPSYSRRRSRSGSPARSKSRTPARSRSRSRSRSGSAPRGRSVSRSRSRSQSANHKRNSVWWELSTALTPQLIPGPGSASWRCVRPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGQ1</accession>
    <name>A0A3P9DGQ1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ankyrin repeat domain-containing protein 13C</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein retention in ER lumen"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
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    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="10">
        <location>
            <begin position="236"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGR2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Keratin_B2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="177" mass="19149" checksum="0992EB4B475413C0" modified="2019-02-13" version="1">EVSSSLNPSKEVRLHPRLVRLHPRLVQLSCLHPRLAQPSCLHPRLAQPSCLHPRLAQPSCLHPRLAQPSCLHPRLVQPSCLLPRLVQPSCLHPRLVQPSCLHPHSTACSALSCRGCPNYESSPVYCSDKHQGTCSCPQPQCPYLGCSVVACCSGGSSAGTSPQSPESVLCTPCRPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJ93</accession>
    <name>A0A3P9DJ93_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 65</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJ93"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034262"/>
    <dbReference type="Ensembl" id="ENSMZET00005035465.1">
        <property type="protein sequence ID" value="ENSMZEP00005034262.1"/>
        <property type="gene ID" value="ENSMZEG00005025612.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017802"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003231">
        <property type="term" value="P:cardiac ventricle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903779">
        <property type="term" value="P:regulation of cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="244" mass="26735" checksum="5E56C3D06ECB7C50" modified="2019-02-13" version="1">MLPCLRRVLRPAFSLRAGTGLTGAALKTHQTPALASPVQLASETPLSVVVQRCHLGTHPLKEPMEPLNSPRGAKEFIYSLHPSERTCLLRELHRFESIAIAQGQLEIAPPTAAQLRYVLLHNALPFVGFGFLDNCIMIVAVSVCFMRHALLALYSLSLWRLAGYVEALASRLGMQIPDLSPKQADMWQTRVSSHTGKAIGVGIGCILGMFPLLFFKDEDEKKEGQTEVKEQTQSPPAPAESSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJW0</accession>
    <name>A0A3P9DJW0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJW0"/>
    <dbReference type="Ensembl" id="ENSMZET00005035657.1">
        <property type="protein sequence ID" value="ENSMZEP00005034446.1"/>
        <property type="gene ID" value="ENSMZEG00005025739.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151352"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042289">
        <property type="term" value="F:MHC class II protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035723">
        <property type="term" value="P:interleukin-15-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042110">
        <property type="term" value="P:T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11422:SF5">
        <property type="entry name" value="DIVERSE IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1.1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11422">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="225" mass="25269" checksum="19FAF7729F1F148B" modified="2019-02-13" version="1">MFSGVNSGDLPLSFTVRDGDKVTLPCETLINNHHNCDTTVWLFTDSRGTPAVELVYLGQIKEQKSDRLSVTAECSLVIKKVTAEDVGRYTCRQFRGNPGKQQGPDAVVYLSEQYNTDQVTLNCSVWTYERCKHKLKWIHDSGGLNRDYSNLKTLQSSCSAAVTFIKSSYSLLSHISNSDFKCSVTTEENKEQLCTFRPQSSGKKPGEIRLRKLLSTDVRKELLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLD1</accession>
    <name>A0A3P9DLD1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome b5 reductase 4</fullName>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flavohemoprotein b5/b5R</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">cb5/cb5R</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_014266996.1">
        <property type="nucleotide sequence ID" value="XM_014411510.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLD1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035565"/>
    <dbReference type="Ensembl" id="ENSMZET00005036822.1">
        <property type="protein sequence ID" value="ENSMZEP00005035565.1"/>
        <property type="gene ID" value="ENSMZEG00005026574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471248"/>
    <dbReference type="CTD" id="51167"/>
    <dbReference type="GeneTree" id="ENSGT00940000155536"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000063">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000021">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000019">
        <property type="entry name" value="cytochrome b5 reductase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="57"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="19">
        <location>
            <begin position="165"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="273"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="518" mass="57662" checksum="51C395FAF64C402E" modified="2019-02-13" version="1">MLNVPTQSFPAPSSQQRVSPSGQSGRNKVALKPGHSLMDWIRFAKSGKDLTGLRGRLIEVTEEELRKHNRREDCWTCIRGMVYNVSAYMDYHPGGEEELMKAAGVDGTELFDQVHRWVNYESMLKECLVGRMSTKAATAVRAILPPPPVTGLASPTSVAPLPDKDSRPRYDWFQTDGTVHLVVYTRRKIPSSGCTTVDLKAGVLRLEVLLGKMSYMIHLRLSDEVEENVAVHTAFSVGKIQVSIRKGAHGKWASLGQPLESHNTFVRQKDRALFYRDCVLVSKTEVNHNTYLFRLQLPAGTVMHVPVGKHVCLKALVQDVEVVRPYTPVEHIFPAASKNGSQESDLYLMIKVYPGGAFTPHLSSLSVGDRVAVSGPEGTFSLRPLRDVTNLYLIAAGTGFTPMARLIRAALEDIETIGNTKLLFFNRREEDILWRFELDELAANNGRFQVEHVLSEPSERWTGRKGPVNEPILTELLSRPDGSKCYVCVCGPAAFTELTLGLLKHQGFSEQELHAFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMD0</accession>
    <name>A0A3P9DMD0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma</fullName>
            <ecNumber evidence="14">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="14"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035574"/>
    <dbReference type="Ensembl" id="ENSMZET00005036831.1">
        <property type="protein sequence ID" value="ENSMZEP00005035574.1"/>
        <property type="gene ID" value="ENSMZEG00005026576.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158901"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13362">
        <property type="entry name" value="PH_PLC_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08592">
        <property type="entry name" value="PI-PLCc_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09932">
        <property type="entry name" value="SH2_C-SH2_PLC_gamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10341">
        <property type="entry name" value="SH2_N-SH2_PLC_gamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11970">
        <property type="entry name" value="SH3_PLCgamma1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000155">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000051">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000004">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000009">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000011">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056586">
        <property type="entry name" value="EF-hand_PLCG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016279">
        <property type="entry name" value="PLC-gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035023">
        <property type="entry name" value="PLC-gamma_C-SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035024">
        <property type="entry name" value="PLC-gamma_N-SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057061">
        <property type="entry name" value="PLCG_EF-hand_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035724">
        <property type="entry name" value="PLCgamma1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF173">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23329">
        <property type="entry name" value="EF_HAND_1_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23583">
        <property type="entry name" value="EF_HAND_2_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000952">
        <property type="entry name" value="PLC-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 14 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 14 17" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="10 14 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11 14" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="20">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="553"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="18">
        <location>
            <begin position="671"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="794"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="22">
        <location>
            <begin position="957"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="1075"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1321" mass="152816" checksum="B3D36668AD1F0699" modified="2019-02-13" version="1">MAGTSGFFSNGPVPWMDNATEMNNLYRDLELGTVLTLFYSKKSQRPERRTFQVKLETRTIIWTRGTDKIEGEIDIREIKEIRSGQKSRDFDRYVEDSAARLDQAHCFVILYGTEFRLKSLSLAATSDEEMTMWVQGLTSLVTDTLKSPTPLQIERWLRKQFYAVDRNREDRISCKDLKSMLSQVNYRVPNMRFLREKLPDSEMRNGDVSFSQFAQLYRSLMFDAQKNVSAVFLCIHRYTFSIRFIDRPEQRISLEDFKSFLLESQKEMWATDNNKVQEFMFGYLKDPLREVEQPYFQQDEFLTYLFSKENTIWDSSLDQVCPENMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPEGMPVIYHGHTLTTKIKFSDVLTTIKEHAFVTSEYPIILSIEDHCSIVQQRNMATHFKKVFGDMLLTKAVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVSTTTPYSENDISNSIKNGILYLEDPINHEWYPHFFVLTSSKIYYSEETSSNPGNDDEEEHREVSYGMDQHVTEKWFHGKLGAGRDGRQIAERLLSEYCLETGAPDGSFLVRESETFVGDYTLSFWRSGRVQHCRIHSRQEAGSPKFYLTDNLVFDTLFALITHYQQVALRCNEFEMKLTEPVPQTNAHESKEWYHANLSRSHAENMLMRVPRDGAFLVRKRAEPNSFAISFRAEGKIKHCRVQQEGQTVVLGTSEFDSLVDLISYYEKHPLYRKMKLRYPINEDTLEKIGTAEPDYGSLYEGRNPGFYVEANQMPTFKCTVRAMYEYKAQRDDELSFTKNAIISNVEKQEGGWWKGDCGGKKQMWFPANYVEEISPSAAEPDRTEMTENSPLGDMLRGSLDVSACQINVRTEGKGSRPYVFTLTQNTPVRIGIPLDIAANTQEELKEWVFKIREVTLTSEAKIEEGKMMERRKKIALELSDLVIYCRPVPFDEEKIGTERACFRDMSSFPETKAEKYVNKIKGKKFLQYNRLQLSRIYPRGQRLDSSNYDPLPMWLCGSQLVALNFQTGDKPMQMNQALFMLNGRSGYVLQPPIMRDDNFDPFDRQTLRGVEQVSLEIEVLGSRHLPKHGRGIVCPLIEIEVCGAEYDSAKQKTDSEADNGLNPTWPRKTFQFTVCNSAFAFLRFVVYEIDMFNDQNFLAQATFPIHGLKTGYRSVPLTNSYNEDLELASLLVHMDITRGRVSSTMFSVRERFGELSSAMAYRGREGSFESRYQSPIDDFRVSQETLLDMDAQNRRCVCVWCVSLCGVRCLSRVFWTCRRLQTLSCLCLHFRIPRRTRVENRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ08</accession>
    <name>A0A3P9DQ08_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 53 member B</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551566.1">
        <property type="nucleotide sequence ID" value="XM_004551509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ08"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036840"/>
    <dbReference type="Ensembl" id="ENSMZET00005038129.1">
        <property type="protein sequence ID" value="ENSMZEP00005036840.1"/>
        <property type="gene ID" value="ENSMZEG00005027454.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474576"/>
    <dbReference type="KEGG" id="mze:101474576"/>
    <dbReference type="GeneTree" id="ENSGT00530000063371"/>
    <dbReference type="OrthoDB" id="9934966at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029356">
        <property type="entry name" value="FAM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28567">
        <property type="entry name" value="PROTEIN FAM53A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28567:SF1">
        <property type="entry name" value="PROTEIN FAM53B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15242">
        <property type="entry name" value="FAM53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="435" mass="47795" checksum="26226481DC5590A4" modified="2019-02-13" version="1">MVIVFSQTLEKKKAANDVTSKSIERRLCEVPTMSRGTTLLSRGTVEADRWLDMGRSCAIQQRAPCQSGTPLWDVTPDHNSHCAKEPGSTTAITSLIRDLSLCNSTHAVSATAHYTTTATSQTPTAPPSKRQCRSLSLSEEFTGFRSSWRPQGSRVWTTVEKRRCHSGGSVRGGGSHFPTMQRSSSFSLPSHSSITFDGIQDLPFFNQPLPLHPQFTASPVSPTSLATHHHHSQNHVFLRPLSLSHEQISLPEHQREEASETSSSDSTPELGRRASQRARGKGCLSRSRSQPCVLNEKKVGMKRRRPEDAQEQRPSLDLTKMTQTLQSLSCPGFSSSDNCQSVLSPPTLDLIDQPDSDFTGVSELGLESWQEVIGDDEEADSSYEDSDSACSVDSRPGSPVGIEDGKRTLWKGDCGTQRDIFQLGGELDLEQIERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ35</accession>
    <name>A0A3P9DQ35_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HLA class II histocompatibility antigen, DR alpha chain-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MHC class II family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024656450.1">
        <property type="nucleotide sequence ID" value="XM_024800682.1"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005036569"/>
    <dbReference type="Ensembl" id="ENSMZET00005037853.1">
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        <property type="gene ID" value="ENSMZEG00005027282.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000161847"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
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    <dbReference type="GO" id="GO:0042613">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
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        <property type="entry name" value="MHC/Immunoglobulin"/>
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        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
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        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001003">
        <property type="entry name" value="MHC_II_a_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF86">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00993">
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    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00920">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018138128" evidence="9">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007394"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="239" mass="26162" checksum="089A5BA9C2F97776" modified="2019-02-13" version="1">MKMKELLLFLSCVLCVSADALHSDITVTGCSDSDGEKMYGLDGEEVAYADFNKKEMIDPQPPFIDRITYQEGTYEYAVADQQICRENMKLFGKGMKDFPPEQDAPSAVMIYTRDEVEFGEKNTLICHVTGFYPAPVNVSWTKNGQKVTGSSINTPYPNKDGTFKQTSRLQFTPQLGDIYSCAVQHLALTEPLTKIYEVEASARSDPGVGPSVFCGVGLTLGLLGVAAGTFFLVKGNECS</sequence>
</entry>
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        <submittedName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Cichlomorphae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005027405.1"/>
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    <dbReference type="GeneID" id="101482424"/>
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    <dbReference type="CTD" id="26575"/>
    <dbReference type="GeneTree" id="ENSGT00940000155393"/>
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        <property type="component" value="LG13"/>
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        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
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        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
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        <property type="entry name" value="RGS_sf"/>
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    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
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    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF196">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RGSPROTEIN"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="83"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="209" mass="24449" checksum="A003BE27B9C67B90" modified="2019-02-13" version="1">MPRSVSGVEMRKRQAAHIEAPPQAPGQPRPNTCCLCWCGCCKCLWNEDRMERSERQTCTKMDSIEATEEQRPSLEEVLSWARSFEMMLRSLEGREVFRQFLRSEYSEDNLLFWLACEELKKETDPTAVDEKARIIYEDYVSILSPKEVSLDSRVREGINQSLAEPSNLMYEEAQLQIYTLMHRDSFPRFLNSSVYRDLLASRRRTCLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRF4</accession>
    <name>A0A3P9DRF4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S1 RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
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            <taxon>Neopterygii</taxon>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
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                <person name="Haerty W."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
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                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
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                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichliformes</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the WAPL family.</text>
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        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="591"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1174" mass="128708" checksum="BBDC3019AE2B09CA" modified="2019-02-13" version="1">MTSRFGKTYNRKGGEANSKFEEVFSNKKPTLTTKWGETTYKAQLGAKRPLLKPDVSEVPKRPRLEDSDSEEDPFGFDSDEESKTVTSHNVSQAKVAEGEVMKTTTVQSTGTAAVVTYAQSSACSTATFTSKQKTEEKVGKNNQPWYKSESQSSQKPAWGTSLSSTVLSDDQNFSQRSTSSSPNIDTSVKLFTDVPGGSRDFQSSSSCDGLLSDEMKGAEVEPSAEAPPEPVDNIPPSPFTLRASNCKKYQRPGRPDKSSSELAESNSNKSTDGASAQDKPNSALSAGASSTAASAKTAAKPVGRGGGRVRDYTVLHPSCLSVCNVTIQDSMERSIDELVSLAPPADLGEAGQMKKKSDTPPPKPTRFRPTQTKTKKTKTETKLEFFGFEDKEDQEGEEGSEAGKSSYKIKYFGFDDLSESDSDDESSQAKEKKARKAAAALAALSSSVDSPHTSDSQDSHASSNTADAFDFSDDSSPGGTEGQKARSGKPSDKSKDVGSGLKKIFSGPKKSPAKAVYNARHWNQHEPEEMPVPPVSRSQTAPAILSSSSKDSNSHKDDGLFKAPPPPPKVIKSETIPTRLNQDIVTALKCRKEDKELYTVVQHVKHFNDVVEFGENQEFTDDFEYLETGLKSSQPLNTRCLSIISLATRCAMPSFRMHLRARGKVAQVFKMLNDAPQHPNLALCTAALMYILSRDRLNMDLDRACLELMIKLLELDQDYSGHQDQLTAKEMAKVKEKIRKLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKGGCWILMCSKPCCTVHMCIPMQRFCLSRFVIATCRVCCIATVKECVDNLSQEDDKENLVASLWGAERCLRVLESVTVQNPENQSYLIAYKDSQLIVSSARALRYCEDMIQRYSRALNNTSLSSSAAALPHCSFTNVGKAVEDCMRAVIGVLLNLTHDNEWGSTKTGEQDQLIVTALNCVLQVPRYIPQEQRFDVRVLGLGLLINLVEYSSRNRHCLVDMEYNVDDTCLEDSLMQPADPTQSDTLAESAETQADTADKPKSCGALAALVKLFLERERAAILAEAKTDDLISEAPKPALDQSGEWQETSGEIQWVASETNDSQPEKKEEEDEELDLNKALQHAGKHMEDSIVASYTALLLGCLCQGSQVKTGADLYILFCPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DT62</accession>
    <name>A0A3P9DT62_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DT62"/>
    <dbReference type="Ensembl" id="ENSMZET00005039322.1">
        <property type="protein sequence ID" value="ENSMZEP00005037925.1"/>
        <property type="gene ID" value="ENSMZEG00005028350.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01070000253760"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029495">
        <property type="entry name" value="NACHT-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14484">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01288">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="49"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="524" mass="59937" checksum="C6DE7B549F6E159C" modified="2019-02-13" version="1">CERVTEGSDATGSRTLLNRIYTELYITEGQSEEVHTQHEVRQLETRPIRVVLTNGVAGVGKTFSVQKFTLDWAEGLENQHVSVVVLLSFRELNLIRDEQYSLLELLHVFHPTLQKVTAEKLAVSQLLFIFDGLDESRLSLDFTNRKLLSDVTQKSSVSQLLTNLIHGNLLPSALVWITSRPAAANQIPPTCVDRLTEVRGFTDAQKEEYFRRKFSDEELSSRIISHMKTSRSLHIMCSIPVFCWITATVLEHMLTTEQRGELPKTLTDMYSHFLLQCGLDVTEASVYSGVCTEIFKRDCVIFQKPVYCFVHLSIQEFLAAVYMFHCFTSRKTKVLRDFLDIWNDITSLHEFLSKSMLRSLQSKNGHLDLFVRFLHGLCLESNQRLLEGLLGQTENSPGTIQRVINNLKKMNSVKISPDRSINIFHCLMEMNDLSVHQEIQEFLKSENRSKRLSEIHCSALAFMLQMSEEVLDELDLQKYNTSEDGRLRLIPAVRNCGARFHNELTRNSEDHQGVLLSLCGGHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AQX7</accession>
    <name>A0A3P9AQX7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Translocon-associated protein subunit alpha</fullName>
            <shortName evidence="11">TRAP-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Signal sequence receptor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 11">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRAP-alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545107.1">
        <property type="nucleotide sequence ID" value="XM_004545050.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AQX7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000084"/>
    <dbReference type="Ensembl" id="ENSMZET00005000119.1">
        <property type="protein sequence ID" value="ENSMZEP00005000084.1"/>
        <property type="gene ID" value="ENSMZEG00005000138.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466691"/>
    <dbReference type="KEGG" id="mze:101466691"/>
    <dbReference type="GeneTree" id="ENSGT00400000022103"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF1">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018100740" description="Translocon-associated protein subunit alpha" evidence="13">
        <location>
            <begin position="29"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="286" mass="31782" checksum="A14454C35420D7BE" modified="2019-02-13" version="1">MFNFTSKLLLLFLLAFPCGLISVGHVYADSDSAEDIVEDSDAAVDEEEDDEDVLVEEDQMQTSEGHEDDSDEAADKLLASHPDADTTIIFTTGEEFPANEIVRFLVGFSNKGSQEFTVQSLEASFRYPQDFQFFIQNFTALPLNTVVKPQAQASFEYSFIPAQPMAGRPFGLVILLNYQDTEGSVFQTAVYNQTVTITEREEGLDGETMFMYVFLAGLVSLLLFGMYQVLDSRTKKRLSVKIEKGTAGINDVDISWIPQETLNAMNKASPKASPRKRTKRAAGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AR94</accession>
    <name>A0A3P9AR94_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AR94"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000180"/>
    <dbReference type="Ensembl" id="ENSMZET00005000226.1">
        <property type="protein sequence ID" value="ENSMZEP00005000180.1"/>
        <property type="gene ID" value="ENSMZEG00005000184.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160817"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000013">
        <property type="entry name" value="Period circadian protein homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057310">
        <property type="entry name" value="PER1-3_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048814">
        <property type="entry name" value="Per1-3_PAS-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF13">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23170">
        <property type="entry name" value="bHLH_PER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21353">
        <property type="entry name" value="Per3-like_PAS-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Period circadian protein homolog PER 1-3 bHLH-like" evidence="5">
        <location>
            <begin position="75"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Period circadian protein homolog 1-3 PAS-A" evidence="4">
        <location>
            <begin position="153"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42210" checksum="548A749EACC1D094" modified="2019-02-13" version="1">MPGGDSGLHGEEPALLSATANGGEVEQELSGKQNGRETSKHLGGEESGVSVTVRNTYLFMLFLCICSSEHAEAGKGQDHREVMNAVAEMKKRLPSDKRSRSKASTVEALHYALNCVKQVQGNLTKYRRRRNATVCTLEELERVTSEHTLKNTDSFVVVFSLASGRVLYASEQAPSILCCKRKFLESAKFVELLFHQDVNVFYSHTAQPHLPPWSNSHTAGVLFDCAQVKSFFCRIRGGKDREGEMRYNPFRITPYQLKVQGSGSSGEEEEPCCLALAERIISGYEAHLYHNTLPGCVFLEVDDRAVPLLGYLPQDLIGTSLLTSMHRKVLKHAGQPPFEHSPVRLHCQNGDYITLDTSWSSFITHGAEGGLHHRAHKVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARL7</accession>
    <name>A0A3P9ARL7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein SSUH2 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARL7"/>
    <dbReference type="Ensembl" id="ENSMZET00005000319.1">
        <property type="protein sequence ID" value="ENSMZEP00005000263.1"/>
        <property type="gene ID" value="ENSMZEG00005000208.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163873"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="360" mass="39977" checksum="109DE46920023076" modified="2019-02-13" version="1">HGNPPAASTFYTMYPPVMAPQANMFGNVPGYEGTVPGGGGFLPPPMPTEPVAPPQPAPENPEWSIPSLSEDEARKAFKEFVSSHCCYSDAPVTQGVITSMEPFNTFRYRLETFTESRSTEWAQKPYEGEPADFYTQPAPQPWEVQATPPNLFSDHKVKIRVPFTSSVKECNTCHATGVEQCTECNGCGKKACWVCDGTGVKLDAACSHCNGTGKESCSKCNGRGKKECQTCKGKRQLLTYIELKKHLQDHVVEHNSGLKTDKLCSVNGKELFKNSQNLVYPLFGFPNPGVSQASDRLIKEHQTKYGQTSRILQQRQTVELIPITRVNYEWKDNTHAYYVYGNEHKVNADDYPATCCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARP6</accession>
    <name>A0A3P9ARP6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:50708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57444"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:90680"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:50709"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:48888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57466"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:90850"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:19057"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:131871"/>
            <dbReference type="ChEBI" id="CHEBI:134019"/>
            <dbReference type="EC" id="1.11.1.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19058"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Has a tendency to form higher mass oligomers. Interacts with FUNDC1; this interaction promotes GPX4 recruitment into mitochondria through TOM/TIM complex where it is degraded by mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARP6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000293"/>
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        <property type="protein sequence ID" value="ENSMZEP00005000293.1"/>
        <property type="gene ID" value="ENSMZEG00005000197.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phospholipid-hydroperoxide glutathione peroxidase activity"/>
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    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:response to oxidative stress"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000111">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF134">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035814"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="168" mass="18788" checksum="28E5647EFCE51D86" modified="2019-02-13" version="1">VQCAQVGDWHSAKSIYEFSAKDIDGDEVSLEKYGYVCIIVNVASKGKTRVNYTQLAGMHASYAEKGLRILGFPCNQFGGQEPGTEAEIKEFAKGYNAEFDLFSKIEVNGDNAHPLWKWMKAQPKGKGTLGNIKWNFTKFLINREGQVVKRYGPTDDPSVVEKDLPTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARR4</accession>
    <name>A0A3P9ARR4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DnaJ homolog subfamily C member 25</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DNAJC25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538609.1">
        <property type="nucleotide sequence ID" value="XM_004538552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARR4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000400"/>
    <dbReference type="Ensembl" id="ENSMZET00005000459.1">
        <property type="protein sequence ID" value="ENSMZEP00005000400.1"/>
        <property type="gene ID" value="ENSMZEG00005000381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482057"/>
    <dbReference type="KEGG" id="mze:101482057"/>
    <dbReference type="CTD" id="548645"/>
    <dbReference type="GeneTree" id="ENSGT00390000013355"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000036">
        <property type="entry name" value="dnaJ homolog subfamily C member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044632">
        <property type="entry name" value="DNAJC25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASX6</accession>
    <name>A0A3P9ASX6_9CICH</name>
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        <submittedName>
            <fullName evidence="11">Methionyl aminopeptidase 2b</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
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    <dbReference type="Ensembl" id="ENSMZET00005000801.1">
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        <property type="gene ID" value="ENSMZEG00005000627.1"/>
    </dbReference>
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        <property type="component" value="LG17"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pept_M24"/>
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        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
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        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="10">
        <location>
            <begin position="137"/>
            <end position="280"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
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        </location>
    </feature>
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            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
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            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000728.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUH5</accession>
    <name>A0A3P9AUH5_9CICH</name>
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        <submittedName>
            <fullName evidence="13">Purinergic receptor P2Y13</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
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                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUH5"/>
    <dbReference type="Ensembl" id="ENSMZET00005001450.1">
        <property type="protein sequence ID" value="ENSMZEP00005001360.1"/>
        <property type="gene ID" value="ENSMZEG00005001141.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01110000267167"/>
    <dbReference type="Proteomes" id="UP000265160">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
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        <property type="entry name" value="7tm_1"/>
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        <property type="entry name" value="P2Y13PRNCPTR"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="59"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001360.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="351" mass="39703" checksum="201A98EB10775160" modified="2019-02-13" version="1">MDLLQYPKHFNISGLPKKCGKTPRLLLCRFTLRCKVRKQQQKKNSITITRLKFAQQQVVADLLMTLTIPLKILTDAGVGSWQLRAFHCRYSAVLFYITMYISILLLGLISLDRYLKIVRPFGKCALQRVRVGQILSAAVWVVMLSLALPNVILSDKPPRPSGNRLKCTSMKSPAGLLWHEGFNYFCQVIFWGTLALMVVCYTFISKKVYESYKASKSRSRGASRKTKAKVFVVVGVFFICFAPFHFVRVPYTLTQTRSATSDCKAQNAVYFAKETTLWLSATNVCLDPLIYVFLCKVFRRRLTAALCIKSLQKGFDSATSTQLEISQIAYSKRLSHNGTSEASEQCTLGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYC1</accession>
    <name>A0A3P9AYC1_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">Cadherin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYC1"/>
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        <property type="protein sequence ID" value="ENSMZEP00005002658.1"/>
        <property type="gene ID" value="ENSMZEG00005002095.1"/>
    </dbReference>
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        <property type="component" value="LG2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_N"/>
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        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
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    </feature>
    <feature type="chain" id="PRO_5018125230" description="Cadherin N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin N-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08266"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002658.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="61" mass="7248" checksum="5B356E26F6231739" modified="2019-02-13" version="1">MTKRIGYRDWRWQAFWWHHFFLLWSTIDAQTRYSIPEELKQGSVVGNLAKDLGLRGGAKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZK9</accession>
    <name>A0A3P9AZK9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAYSVFN motif domain containing 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
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                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004550550.1">
        <property type="nucleotide sequence ID" value="XM_004550493.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZK9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003103"/>
    <dbReference type="Ensembl" id="ENSMZET00005003231.1">
        <property type="protein sequence ID" value="ENSMZEP00005003103.1"/>
        <property type="gene ID" value="ENSMZEG00005002413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473697"/>
    <dbReference type="KEGG" id="mze:101473697"/>
    <dbReference type="CTD" id="55776"/>
    <dbReference type="GeneTree" id="ENSGT00390000004313"/>
    <dbReference type="OrthoDB" id="71310at2759"/>
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        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039159">
        <property type="entry name" value="SAYSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019387">
        <property type="entry name" value="SAYSvFN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527:SF0">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10260">
        <property type="entry name" value="SAYSvFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SAYSvFN" evidence="3">
        <location>
            <begin position="97"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="175" mass="19402" checksum="BC17A5B1CDE07D0E" modified="2019-02-13" version="1">MEQKLAEFRARRQAEKAAQKSETTGSQSRGETAADTAAQCDKTPTADSLQPEDRARNNQTATDGSQSSDRGDWLLDSALGKWLASRQFVISNITLLKVLLWLVLLGLFAELEFGLPFFVISLFYWLYEGLRSPAPRKPGELSAYSVFNPDCQPLLGALTAEQLEGEMGYRPLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2H3</accession>
    <name>A0A3P9B2H3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Family with sequence similarity 174 member C</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM174 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2H3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004101"/>
    <dbReference type="Ensembl" id="ENSMZET00005004271.1">
        <property type="protein sequence ID" value="ENSMZEP00005004101.1"/>
        <property type="gene ID" value="ENSMZEG00005003176.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064649"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009565">
        <property type="entry name" value="FAM174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607:SF2">
        <property type="entry name" value="PROTEIN FAM174C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06679">
        <property type="entry name" value="DUF1180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018249740" evidence="9">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="136" mass="15303" checksum="15A192549E970684" modified="2019-02-13" version="1">MTFYRSLSAVLVSVCWVLLSVAEEVKNSTETRRTAATNSSRVNAINGTSKGPLNTFNVDSSMIQRALYVLVGITIIGVLYFLIRAVRLKKPTHRKKYGLLSNEDDAVEMDAVDSDEDDTLYKSRSLRRSEVNRQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3S4</accession>
    <name>A0A3P9B3S4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004571195.1">
        <property type="nucleotide sequence ID" value="XM_004571138.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3S4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004422"/>
    <dbReference type="Ensembl" id="ENSMZET00005004624.1">
        <property type="protein sequence ID" value="ENSMZEP00005004422.1"/>
        <property type="gene ID" value="ENSMZEG00005003462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469262"/>
    <dbReference type="KEGG" id="mze:101469262"/>
    <dbReference type="GeneTree" id="ENSGT00390000016307"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01518">
        <property type="entry name" value="RHOD_YceA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000022">
        <property type="entry name" value="Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057944">
        <property type="entry name" value="TSTD2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF6">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23949">
        <property type="entry name" value="TSTD2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="274"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00069711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="463" mass="52762" checksum="F7923B6060EE5898" modified="2019-02-13" version="1">MAADDTPCSEFINWEVDSSICNGFKQEKQLSAPQRRYYSFCRRKSFAAFVASKKDGSHEEGSPLWCCCGQTFIEHAAIHKHVARVHNAEIQQLAQDEYEHLFSQLEEEPEATQVNEHSGETVDVSVWIPDISHISEEQLKNGPGRVLLYYHYCCVEEPHVICAWQKALCEKLHLTGKVRVATEGINGTVGGTNLATDIYIEAMRSHPLFEMDEEDFKTSDGGAECFTELKVGVYKEIVPMGVDPDLISYELAGVHLEPDEFHKEVEALLTKGDSCNDTVLLDCRNYYESKIGQFTQCLAPNIRKFSYFPDYVDQNLELFRDKKVLMYCTGGIRCERGSAYLRSKDVCKEVYQLKGGIHKYLERFPEGFYRGKLFVFDERYAISSNSDIISDCRYCGHPWDQYKLCSTQYCCQLVLSCPSCRQDGHTACCPTCQTKGQAQSEETSHHKEECECTDVRPRIPQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B458</accession>
    <name>A0A3P9B458_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Platelet-activating factor receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with ARRB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
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                <person name="Mwaiko S."/>
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                <person name="Penman D.J."/>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="626"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="817"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="741"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111391" checksum="5419AF4BC2FCCE5F" modified="2019-02-13" version="1">MAATSSLQSKGLGLVLVEFGYEYEGRDGALVTIKPNERYILLAKTNNHWWQVQEDRSSKPFYIPAKYVKELPLELPSPLDFADPPSPELVLPVVAPIPVAVPVLIPKPLEESRTKPSDDMTIRLTPDAVKRHHKNENRMSTFGVPLDFQDVAPRLPGAPAGPAEPGSTANNRTANSADGKKPPHLSGYVEDARDAGKPRVPSFSPADPLSVPRPQAQPIRVETPVIPPHSSLHNMSSSPAGRPDGHESPIEPDEEELAEEEANVEESVEESDEEGRDSGKGEDSHHIYESIQDLNLDLEALVGARASPAAQVEPATPEAAPAPPPTQDQSLPDPLSPIYANIPSLKKLAPPQGPSGSSLSSPPPTDHSLSTSDHSPSSSTSLGMTSPNCPVSAQDRLQGHTEQDSGRQPGTNHMNNSRNPPPVPVRDLDRSKGKEGGQLTSISPASSQGSGGWEKVFDEVSGRPYYFNRSTRTTSWNLPEPSSPSPPPGSATHRKHEGGPPPLPEEDYPVGDHKDNNANFRTHPQQSLGLIPRAHLDLKDPQIPSVPQSLMGNGVCEDGASLQARKLRVSMGEDTCSHGHRRNFSDHTDMISRHASPDSPQLSNRCRLKRNLSNQSTGSSSQHGHLLEKAGILNKTKVAENGKKIRKNWSQSWTVLHGGILTFHKDPRPAGNASKASQIVPEYTVELRGASVSWACKDKSSKKNVLELKTRQGCEYLMQYDKESIISDWLKVIQDTIGQLVPDGAHRPDQEHLSDSEDDGSSDKEDKDRRSILSRIPSGADTEQTRVRSKLRRFLQRRPTLQSVKERGYIRDNVFGCHLDTLCHREHSTIPKFVEKCIRTVERRGLDVDGIYRVSGNLAVIQKLRHKADHEEHLDLEDGQWEEIHVITGALKLFLRELPEPLFPFSVFEKFIAAIQVPDYSLRVSYMKDLVQTLPLPNHNTMELLFRHLRKVIEHKDSNRMSVQSIAIVFGPTLLRPETESANMTIHMVFQSQIVELLLNEFPTVFSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B562</accession>
    <name>A0A3P9B562_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol polyphosphate-5-phosphatase Ka</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B562"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005036"/>
    <dbReference type="Ensembl" id="ENSMZET00005005260.1">
        <property type="protein sequence ID" value="ENSMZEP00005005036.1"/>
        <property type="gene ID" value="ENSMZEG00005003900.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156538"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016312">
        <property type="term" value="F:inositol bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09094">
        <property type="entry name" value="INPP5c_INPP5J-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000066">
        <property type="entry name" value="Inositol polyphosphate-5-phosphatase Kb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000003">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041611">
        <property type="entry name" value="SKICH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF117">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17751">
        <property type="entry name" value="SKICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="491" mass="57071" checksum="2639E49F7E499092" modified="2019-02-13" version="1">MEDSEEPLESHQLYLGEKEEESFRLHMVTWNVATADPPDDVTTLLHLNSPKSPDLYVIGLQEVYSGPLRFVSDAVFDDPWSYLLMSLLAPQKYIKVSSIRMQGLLLLFFSKLEHVPFIRDVQATYTRTGLFGYWGNKGGVSIRLSFYGHTLCFLNCHLAAHMNYASERVDEFEYIMDMQSFDCKRAPAIVDHRLVFWFGDLNFRIQDHGMHFVRTCIDKQNYSLLWSKDQLIMMKQKEQVLQEFEEGPLDFQPTYKFDRSSDTYDTRLYNTWFGFNAKKRKPAWTDRILWRLRPKALPPDEENENKVGLDAKKLKQLEEDMEYPLKIRQDVYTSMMEYSISDHKPVIGIFTLELRKMYETPLVRLRAEGDWSADIDAMVVYSPLQPFPSSTWDWIGLYKVGFSSVSDYITYTWVKDDEVAFNEEVIQVYVSKEEIPVQGGDCVLCYYCNALKCIIGISEPFQVQASKVAIEEGMLPERINGLDKAVSGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5D7</accession>
    <name>A0A3P9B5D7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Solute carrier family 22 member 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5D7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005090"/>
    <dbReference type="Ensembl" id="ENSMZET00005005314.1">
        <property type="protein sequence ID" value="ENSMZEP00005005090.1"/>
        <property type="gene ID" value="ENSMZEG00005003953.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167667"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19076" checksum="84D0E0FFCADF04AD" modified="2019-02-13" version="1">MKDFGEVTNTVKIRDYDTITAFLGSWGPFQLRIFLALAISILPNGFIGGYIVFIGAIPSHECYIPENYNISEMWKNVTIPLETVSGNAKRSSCSRLNLDVVRNYSQNNIIPNVDVNVSEIPWESCIDGWLHSKSIYQSTIVTEWDLVCENAYKLPLTSSIYYVGVLLGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5S5</accession>
    <name>A0A3P9B5S5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Si:dkeyp-113d7.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014265813.1">
        <property type="nucleotide sequence ID" value="XM_014410327.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5S5"/>
    <dbReference type="Ensembl" id="ENSMZET00005005457.1">
        <property type="protein sequence ID" value="ENSMZEP00005005230.1"/>
        <property type="gene ID" value="ENSMZEG00005004065.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469575"/>
    <dbReference type="KEGG" id="mze:101469575"/>
    <dbReference type="GeneTree" id="ENSGT01150000286936"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002281">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF151">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="529" mass="57813" checksum="1C404C1390142241" modified="2019-02-13" version="1">MTDLESECLSLGLPPECGSPPLPLDSSLQVDCGAGPVGSTPTPTLALLSSDCPTPTLSSLAAEIAEPLVMLPCVKSEPEDCDLEPIRTVDLSEIQPLSTAELGQDQIKMEISGLDYIKSEHHGNHHLGPFHHSDVTELDYKLHYEPSSVFDYISQVTDTLEYIKSDHHVDLQCYYTTDLSALKSEYPETNAMSAHLQHNGLESIHMAELRTELNKLRPDSLHLDSIGKPDAEFGGGALYELQPTHVGKSSTEAMMAAGRAGGSLVVTTKTQSPTVRKPRNMQGEKPFSCTQCGKNFSTLGNLKTHQRIHTGERPYTCSQCGKSFGQAGNLKRHQLIHTGQKPYVCAHCPKGFTKADDLRSHQRLHTGERPFICTTCGKSFSQSKELKAHHLSHTGERPYCCQHCGKSFTKETSYRNHVQIHTGEKPFTCSQCGKTFSNSGVLKTHEKIHTGERPFGCTQCGKSFGRLGHLKAHQQIHTGERPYACPQCGKTFSQSGHLKAHEQIHKRERADTASTSSDGGSSAVGSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6B7</accession>
    <name>A0A3P9B6B7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/arginine-rich splicing factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Splicing component, 35 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Splicing factor SC35</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Splicing factor, arginine/serine-rich 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004556705.1">
        <property type="nucleotide sequence ID" value="XM_004556648.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004556706.1">
        <property type="nucleotide sequence ID" value="XM_004556649.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004556707.1">
        <property type="nucleotide sequence ID" value="XM_004556650.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6B7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005430"/>
    <dbReference type="Ensembl" id="ENSMZET00005005660.1">
        <property type="protein sequence ID" value="ENSMZEP00005005430.1"/>
        <property type="gene ID" value="ENSMZEG00005004205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484067"/>
    <dbReference type="KEGG" id="mze:101484067"/>
    <dbReference type="CTD" id="406691"/>
    <dbReference type="GeneTree" id="ENSGT00940000154883"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12311">
        <property type="entry name" value="RRM_SRSF2_SRSF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000504">
        <property type="entry name" value="Serine/arginine-rich splicing factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051106">
        <property type="entry name" value="RNA-bind/splicing_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028">
        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN RZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028:SF4">
        <property type="entry name" value="SC35-LIKE SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="111"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="225" mass="26181" checksum="7D27A41E57AFC589" modified="2019-02-13" version="1">MSYGRPPPDVEGMTSLKVDNLTYRTSPETLRRVFEKYGRVGDVYIPRDRYTKESRGFAFVRFLDKRDAEDAMDAMDGALLDGRELRVQMARYGRPPDSMYSRRGPPPRRYGYGRRSRSRSASPRRRRRSHSRSRSRSRSRSRSRHHYSRSRSRSYSRSRSKSKSKSRTPRRSKSKSPSRSRSRSRSKSRSRTPASNRGSRSKSKSRSRSKSKSRPKSPEDTGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCG5</accession>
    <name>A0A3P9BCG5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized LOC101486581</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004571095.1">
        <property type="nucleotide sequence ID" value="XM_004571038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCG5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007582"/>
    <dbReference type="Ensembl" id="ENSMZET00005007898.1">
        <property type="protein sequence ID" value="ENSMZEP00005007582.1"/>
        <property type="gene ID" value="ENSMZEG00005005763.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486581"/>
    <dbReference type="KEGG" id="mze:101486581"/>
    <dbReference type="GeneTree" id="ENSGT00940000162676"/>
    <dbReference type="OrthoDB" id="8386779at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF127">
        <property type="entry name" value="NITR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018102545" evidence="9">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="146"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="348" mass="38900" checksum="FF91B3EE72F25F4F" modified="2019-02-13" version="1">MVSSVFVFRLLCLFLGKMVQMTESQMFSSVHQESRFISAQVGGNLTLKCFHDGDRSARLYWFKQNLGQKPKIISHFFKYNVNNSFSEELKNNPRFTLDTQDGKYHLTIKDLQVSDSASYYCVYYLYTLTFLENIIISVKGSGVNIKAVVQQSASETIQPGGSVTLNCTVHTGTCDGEHSVYWFKDSGESHPGLIYTHLGRNDQCDNKPSTQTHTCVYSLPMSNLSVSHAGTYYCAVTSCGHILFGNGTKLEPKGTFNSQGLVYFLSGALTFSSILSVLLGYLLYKTNKRNRHQSTESQARFSGPATSSEGYQHADSLHYAALSIKIPKRSRTQRNNTDDECVYSAINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCQ1</accession>
    <name>A0A3P9BCQ1_9CICH</name>
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        <recommendedName>
            <fullName evidence="10">Protein piccolo</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aczonin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="9">Presynaptic active zone</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ENSMZEP00005007668.1"/>
        <property type="gene ID" value="ENSMZEG00005005817.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:GABA-ergic synapse"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein localization to synapse"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ_RIM-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Piccolo presynaptic cytomatrix protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Piccolo presynaptic cytomatrix protein"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="C2 domain"/>
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        <property type="entry name" value="C2_dom"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
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    <dbReference type="InterPro" id="IPR052098">
        <property type="entry name" value="Presynaptic_Scaffold_Bsn/Pclo"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="PICCOLO/BASSOON"/>
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        <property type="entry name" value="PROTEIN PICCOLO ISOFORM X1"/>
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    <dbReference type="Pfam" id="PF00168">
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            <location evidence="1">Nucleus</location>
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        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
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        <location>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGT2</accession>
    <name>A0A3P9BGT2_9CICH</name>
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        <submittedName>
            <fullName evidence="3">Chromosome 1 open reading frame 52</fullName>
        </submittedName>
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        <name type="scientific">Maylandia zebra</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the UPF0690 family.</text>
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        <property type="entry name" value="DUF4660"/>
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        <property type="entry name" value="UPF0690 PROTEIN C1ORF52"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UPF0690 PROTEIN C1ORF52"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="220" mass="24569" checksum="A713EC23067BA589" modified="2019-02-13" version="1">MTEEKKTGSLGFFSSYDDLSDSSNDSDSDDQGGSRKKKAGTEAEGSARSSLPGTKRDAGGAPLPKPDELFRSVSKPAFLYNPLNKQIDWDSLTVKAPEEAAREFKPWKTNAVPPPESYTAEPEKKKGPPPGMDMAIKWSNVYEDNGEDAPQAYTGKARFLPEEEQPSDSDEESEKPGLSAKKRRVETFQQKEKRKRDFGQATSDKNFVEEEKRILRQKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIB3</accession>
    <name>A0A3P9BIB3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="2">1.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004566863.1">
        <property type="nucleotide sequence ID" value="XM_004566806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIB3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009637"/>
    <dbReference type="Ensembl" id="ENSMZET00005009996.1">
        <property type="protein sequence ID" value="ENSMZEP00005009637.1"/>
        <property type="gene ID" value="ENSMZEG00005007295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465132"/>
    <dbReference type="KEGG" id="mze:101465132"/>
    <dbReference type="GeneTree" id="ENSGT00920000149172"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08250">
        <property type="entry name" value="Mgc45594_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="70"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="404" mass="42766" checksum="F023725CAF6BE5BD" modified="2019-02-13" version="1">MSRALLARNGRRALPLIYGGRRGTDTLSGVHLAARRFIVDMSYSAHFMDFKGSSIASSMKKLVVTKLSPNFREAVSTQTVAVPTPGDADLLVRNRFVGINASDINYSAGRYDPSVKPPFDAGFEGIGEVVGLGLSASSRYTVGDTVAYFGSGAFAEYTVVPAKEAVPVPAVKPEFLTLLVSGATAYIALKRLGDLAKGETVLVTAAAGGTGQFAVQFAKQAGCHVIGTCSTNEKAGFLKSIGCDRPINYTAEDLAKTLRKEYPQGIDVVYESVGGSVLELAVNSLANKGRLIVIGFISGYQSASGIPPFKGGTLPVKLLQKSASIRGFFLPHFLGDYREALSSMIQMFAKGKLVCEVDCGDLAEEGKFVGLDAVFRAVDYMYAGRNLGKVVVEVAPPSVSNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ46</accession>
    <name>A0A3P9BJ46_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ankyrin repeat domain-containing protein 16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with AARS; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004575308.1">
        <property type="nucleotide sequence ID" value="XM_004575251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ46"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009908"/>
    <dbReference type="Ensembl" id="ENSMZET00005010273.1">
        <property type="protein sequence ID" value="ENSMZEP00005009908.1"/>
        <property type="gene ID" value="ENSMZEG00005007496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482033"/>
    <dbReference type="KEGG" id="mze:101482033"/>
    <dbReference type="CTD" id="54522"/>
    <dbReference type="GeneTree" id="ENSGT00940000153969"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000336">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="371" mass="40759" checksum="A825CB02CCD50475" modified="2019-02-13" version="1">MHENTSKLLVKLTQDGQLAALEKHITLGGSTAAQTVSGKHFGKSGDTLLHYAARHGHLDIVKYLIKRVGLDVEVYNNDYKRPLHEAASMSHKDCVSYLLQEGAKVDSLKKADWTPLMMACTRRNLDVIQELLCHGADPALRNKDGWNSFHIACREGDPVVIQHLLLVAPDVWRTESRTRRTPLHTAAMHGCEEVVKVLLDRCGYMPDSTDSCGVTPFMDAIRNGHISVARLLLDEHQASAAAADILGAQPVHQVAVTGQDEALRFLVKDLNVEVNQRATSIQLTALHYAAKEGHTSTINTLVELGADPHARDKKGRTALHMACIGQHADAARTLLQLGLKDSEDASGTTARQLARKPHVVQVFERDLAHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJA6</accession>
    <name>A0A3P9BJA6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJA6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009987"/>
    <dbReference type="Ensembl" id="ENSMZET00005010353.1">
        <property type="protein sequence ID" value="ENSMZEP00005009987.1"/>
        <property type="gene ID" value="ENSMZEG00005007565.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164472"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="317" mass="35520" checksum="138F9F3D93AD0493" modified="2019-02-13" version="1">FCHLTLCVQDIARTKFRIKFRLTDTIFSYPLHPYPITSASHRAPACPVETLFLFSQVAVAIKVNKSNPEILQQAKLEIFILEQLRRLDPDAANIVKWNGFFLDRERVCLKFELLDQCLWDYIGDPNNRCLPISEVRPILGQLTNALSHLGSLGIVHADLKPGNIMVVNRYESPVKVRLIDFGLACPASAVMPGDRVGTVGYSAPEVMLGLPYNEACDMWSLGLVAVELGTGLDYRDEVNRLTEWCSVNNLQLNTTKTKELILDFRKGRADPAPLYIHGSCVERVHSMRFLGVQISDDLSWTANTTAVVKRPSSVSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJM6</accession>
    <name>A0A3P9BJM6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorting nexin 13</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJM6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010117"/>
    <dbReference type="Ensembl" id="ENSMZET00005010485.1">
        <property type="protein sequence ID" value="ENSMZEP00005010117.1"/>
        <property type="gene ID" value="ENSMZEG00005007619.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182856"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010667">
        <property type="term" value="P:negative regulation of cardiac muscle cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001237">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06873">
        <property type="entry name" value="PX_SNX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08719">
        <property type="entry name" value="RGS_SNX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000014">
        <property type="entry name" value="Sorting nexin 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037437">
        <property type="entry name" value="SNX13_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037896">
        <property type="entry name" value="SNX13_RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="97"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="373"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="559"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="954" mass="110874" checksum="5E38305C0D1FD75A" modified="2019-02-13" version="1">MFAEASLSIWGWGGLGVVLFLVTFGPFAIFYLAFYIFCFIGGGFAVTLLYGKINSEKHLEKCEHSYLPPTQIGILKTLDEMKLEMKPIKIDRRLTGSSFIDEPLQQVIQFALRDYIQYWYYTLSEDESFLLEIRQTLQNALVQFSTRSKEVDWQPYFTTRLVDDFATHLRVFRKAQDRLGDREDKLRDITDDLMESFFEAEVEMERKICRDVVCTSHKDEEGFLRDLCELLLYLLLPPGDFHNKNMRYFLREVLARGVLLPLINQLSDPDYINQFVIWMIRDNSCNYEAFMNILKLTDKPAELEAVRDKVLEELQFLRSLDTAGDDINVIKNQINSLLFVKKVCETRIQRLQSGKEVDAFKLAANFGKLCVIPLDHILVHNIALQFFMDFMQAAGAQAELFFWLTVEGYRVTAQQQLEAMQSWQKDGKKQPSDTKGLLKAAALGVYEQYLSDKASPRVQVDEASLTRLGEKLRKDDPTPEIFDEIQRKVYDMMLRDERYYPSFKQSPLYVRMLAELDMLKEPSYRGSDDGDGESFNGSPTGSINLSLDDLPNSCHDESMHLHAFISDTGVCNDHGKTYALYTITVVRRNQDGSEDAWKTYRRYSDFHDFHMRITEQFENLASILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLNPEMVKACPTLIPYVYDFLENKAYSKGKGEFARKIDTFVNPLRSSMRNVSNAVKAFPDSLAEGVTKVSDNMGRMSEKLGQDIKQSILKVPPILPKSEIDPEHCRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKEKNQWLRRNIKNLLQQLIRATYGDTINRKIVDHVDYLTSPEQVADYVKRFRDSYWPNGILAETPPRRDKNIRMRTRVAAKTSLLGIMPDELKHIIGADTTRKGILRVFDMFQYQPMNRRLVYVFLEGFLETMFPQYKFPELFVKLHSRSPRIHRYNQKLKSTSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJS3</accession>
    <name>A0A3P9BJS3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Distal membrane arm assembly complex 1</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004547994.1">
        <property type="nucleotide sequence ID" value="XM_004547937.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJS3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010158"/>
    <dbReference type="Ensembl" id="ENSMZET00005010527.1">
        <property type="protein sequence ID" value="ENSMZEP00005010158.1"/>
        <property type="gene ID" value="ENSMZEG00005007684.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101466704"/>
    <dbReference type="CTD" id="90871"/>
    <dbReference type="GeneTree" id="ENSGT00940000174023"/>
    <dbReference type="OrthoDB" id="6340866at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053117">
        <property type="entry name" value="DMAC_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36469">
        <property type="entry name" value="DISTAL MEMBRANE-ARM ASSEMBLY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36469:SF1">
        <property type="entry name" value="DISTAL MEMBRANE-ARM ASSEMBLY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="91" mass="9367" checksum="E249C1AAB195E76E" modified="2019-02-13" version="1">MSTGLEPPTGGADAPVSKPSQMFKSCWSCRLISGGGLILSGAYVFHAARKVMRQGGPTSMGTVAQITFAASLAAWGIVVITDPVGKAQRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BT31</accession>
    <name>A0A3P9BT31_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FIIND domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BT31"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013115"/>
    <dbReference type="Ensembl" id="ENSMZET00005013564.1">
        <property type="protein sequence ID" value="ENSMZEP00005013115.1"/>
        <property type="gene ID" value="ENSMZEG00005009852.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263761"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025307">
        <property type="entry name" value="FIIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051249">
        <property type="entry name" value="NLRP_Inflammasome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985:SF2">
        <property type="entry name" value="APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13553">
        <property type="entry name" value="FIIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51830">
        <property type="entry name" value="FIIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIIND" evidence="5">
        <location>
            <begin position="53"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="234" mass="26966" checksum="8877CF69F5B693CF" modified="2019-02-13" version="1">TRKRSFKESPFSVIQNAVYVWMKQLRCQKYPKQFSFGFIPRGNSLFCIRFTRLLSVFPFTLLFLHECVFNSCFSLQSAAGHFECRVSGLRWVCKGKTSFQYQFRSWEGHMERMESRQYMPAGPLMDVTVTAGKLNEVHLPHWIYDIPDILDTFAVLHIDDCGDVVEKVSEVTPTHVKLTEPIFSPRAVLMKLGIPVKIGCNVLIYQTNTAFLTLHVYLIPRDPGLQQVITCFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVB1</accession>
    <name>A0A3P9BVB1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane protein 120Aa</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMEM120 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014264723.1">
        <property type="nucleotide sequence ID" value="XM_014409237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVB1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013576"/>
    <dbReference type="Ensembl" id="ENSMZET00005014035.1">
        <property type="protein sequence ID" value="ENSMZEP00005013576.1"/>
        <property type="gene ID" value="ENSMZEG00005010196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472119"/>
    <dbReference type="KEGG" id="mze:101472119"/>
    <dbReference type="CTD" id="100005623"/>
    <dbReference type="GeneTree" id="ENSGT00390000007848"/>
    <dbReference type="OrthoDB" id="2015098at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012926">
        <property type="entry name" value="TMEM120A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433:SF1">
        <property type="entry name" value="ION CHANNEL TACAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21433">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07851">
        <property type="entry name" value="TMEM120A-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="352" mass="41915" checksum="3BA7FDB962A03893" modified="2019-02-13" version="1">MPEGKMLFSPGGLSECLREWEDLDKDYQQIQDTHRLYKQKLEDVTKLQDSCSNAIARQRKKLKELTVSLEECKSNSSTAKLSPEEEDAIAEIEDSIKDRAHTFFEMEAFLPKRNGLYLNLVLGNVNITLLNKQSKFAYKDEYEKFKLVLTVILFVFSFTCRFLLSYRVLDALFNFLLVWYYCTLTIRESILISNGSRIKGWWVFHHYVSTFLSGVMLTWPEGALYQMFRNQFLSYCLYQSFIQFLQYYYQSGCLYRLRALGERHNMDLTVEGFQSWMWRGLTFLLPFLFFYHFWQLYNSITLFRMFQLPECKEWQVFMCGCSYLVLFMGNVFTTLAVVYQKYMNNQDKSKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVR2</accession>
    <name>A0A3P9BVR2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hyaluronidase</fullName>
            <ecNumber evidence="6">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVR2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014043"/>
    <dbReference type="Ensembl" id="ENSMZET00005014515.1">
        <property type="protein sequence ID" value="ENSMZEP00005014043.1"/>
        <property type="gene ID" value="ENSMZEG00005010410.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230364"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000065">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF20">
        <property type="entry name" value="HYALURONIDASE PH-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="744" mass="82635" checksum="0FBD2684BCFD7446" modified="2019-02-13" version="1">MVSVAQSSRRCVLLLLFRTRSIFPISFFTLALAALTAPKTVALPAADINKSILILPATISTLSVEKSYSVSQSYSTFSSPARTPQTLSKLPIKTDSNAKSSTSETSVQLINPAPHRDVANSPITSKNIHPFGKEVSPSPYSGHCRHTFFYPVQPLKQISWLPSNPCKHLNLSHKATAPFSHKHSQSPHTKSCLYPLSTGKVHLQLAKTSKTQSPLPPASLSPLSNSTSPQSALKKRLAPLSVSPLSAALTFKTTLPALSKTSPLLPYNTTSSPPEATTPRLAPAHLPHTVGPLFEHQPFIVTWNIPDLVCKRYNISLDTSAFKGVATPAKVPGQFLSLFYTDRLGLYPHIDLKSRKEFYGGIPQRANLKASLEKARADINYYIPSMTNRGLAVIDWEEWRPLWDRNWGTKRIYQTLSVAHVMQANLSLSVQQATVKAKQQFQEAARNLMSGMLALGRAMRPNYLWGFYLFPNCYNYGWKDQHYTGQCSKEVRRQNDELLWLWESSTALYPSVYLQVADNPKAALMVRNRVQEALRVSALPGWSATAPVFVYMRPVFVDDNKRFLSQGDLISTVGESVAVGASGAVLWGASGDYDDQLSCEALSFYLTSTLNPYITNVTTAAQLCSDFLCRGNGRCVRKNYKSSHYLHLNPESFRVVNTQKRYFVLGSPSLADLKSLSRRFNCQCYKGLKCTPRTYKELAKALMFSVKRGQYQNSPTLRKVGLDDTEQASTAKDKVNKNFNAADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BW55</accession>
    <name>A0A3P9BW55_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exosome complex component MTR3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exosome component 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">mRNA transport regulator 3 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Non-catalytic component of the RNA exosome complex which has 3'-&gt;5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the RNA exosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564646.1">
        <property type="nucleotide sequence ID" value="XM_004564589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BW55"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014235"/>
    <dbReference type="Ensembl" id="ENSMZET00005014711.1">
        <property type="protein sequence ID" value="ENSMZEP00005014235.1"/>
        <property type="gene ID" value="ENSMZEG00005010720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479853"/>
    <dbReference type="KEGG" id="mze:101479853"/>
    <dbReference type="CTD" id="118460"/>
    <dbReference type="GeneTree" id="ENSGT00940000153348"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000035">
        <property type="entry name" value="Exosome complex component MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="14">
        <location>
            <begin position="45"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="274" mass="29905" checksum="9217D481BEA1BF82" modified="2019-02-13" version="1">MPTDTKRVRGPEVSQSPSLFSCDPAAVLPSKGPRADGRRRDQVDVRPVFVRCGLVSQAKGSAYLEAGNTKLMCCVYGPRETDRKDETNMKCGRLTTDMRFAPFSCPERGSWIQGSQDKDFSLMLHESLQPAICLHKYPRSQIEVNVMVLENSGSVLAHAVTCASLALADAGIEMYDLVLGCSMRQDGTSYVVDPSYMEENCWNSVSCENQGGLTVAFLPSLNQISGLQSDGEMTEETLTAGVRTCIEGCYKLYPVIQHALTKAVRKAAPSQSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWF6</accession>
    <name>A0A3P9BWF6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573760.1">
        <property type="nucleotide sequence ID" value="XM_004573703.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWF6"/>
    <dbReference type="Ensembl" id="ENSMZET00005014695.1">
        <property type="protein sequence ID" value="ENSMZEP00005014219.1"/>
        <property type="gene ID" value="ENSMZEG00005010704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484228"/>
    <dbReference type="KEGG" id="mze:101484228"/>
    <dbReference type="CTD" id="555229"/>
    <dbReference type="GeneTree" id="ENSGT00940000163157"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF233">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="698" mass="78562" checksum="B7AB915A04B27E7A" modified="2019-02-13" version="1">MTEKPPLDGSEGRTWMEEGRSQTQLTAVDGPDEAATDDGDRPAWDSKIQYVLAQVGFSVGLGNVWRFPYLCHQNGGGAFMLLYVFLLVVVGVPLFFMELAAGQSIRQGSIGVWKHISPKLGGIGYSSCMVCFYVALYYNVIIAWSLFYMGNSFQYPLPWEKCPTNVTSNDTVKECAGSSPTSYFWFRKALNITNSIEESGEFNPIMTGCLLAAWAIVALAMIKGIKSSAKVMYFSSIFPYVVLFIFLIRGLLLDGALEGITYMFYPKLEIWGNVQVWRQAATQVFFALGLGYGSVIAYSSYNPVHNNCHRDALMVSCINFMTSVLASLVVFIVLGFRAKNIALRCVAENLSVLNLLASSGSNQHWWPWFNMTDVSTVTLAEYREWYHLYSSMVGPKITDCSLEQEMNKGVEGTGLAFIAFTEVMAFFPASPFWSALFFLMLLNLGLSTMFGTMQGILTPLMDNFSLLGHHRTLLTVSSCALGFIIGLLFTQRSGNYFVTMFDDYSATLPLVIVVIFETISVAWVYGTDRFLDDIEIMLKWRPPVVYKYLWKYVCLLAMVSLLAASLLRMVFKGPTYTAWNQSTASEMTLEYPGWALAMIIMLIVFASLPVPVSYIYSLVKNRWVRSTPSQVEVGQEMRRELYTKCSSTEQPDSHFQPVHFREDEVHPRPAFLSVGNEHYRLLSQEEDEEEEEEQDTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWY7</accession>
    <name>A0A3P9BWY7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWY7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014493"/>
    <dbReference type="Ensembl" id="ENSMZET00005014976.1">
        <property type="protein sequence ID" value="ENSMZEP00005014493.1"/>
        <property type="gene ID" value="ENSMZEG00005010906.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163309"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="124" mass="13643" checksum="31835C97916A3063" modified="2019-02-13" version="1">MAQSTLDSMPGASTGTVVVTEPLNFWGGKRVKPRQEKNAEPVFEPATGRVLCQMVPCGAEEVDEAIQSAYAAYQKWSKMAGMERARVMLEAARIMRVRRPSCCVTTTSRPGNCLVQCLCNINWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BX60</accession>
    <name>A0A3P9BX60_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ADP-ribosylation factor-like 8Bb</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004571996.1">
        <property type="nucleotide sequence ID" value="XM_004571939.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BX60"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014221"/>
    <dbReference type="Ensembl" id="ENSMZET00005014697.1">
        <property type="protein sequence ID" value="ENSMZEP00005014221.1"/>
        <property type="gene ID" value="ENSMZEG00005010708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468561"/>
    <dbReference type="KEGG" id="mze:101468561"/>
    <dbReference type="CTD" id="562445"/>
    <dbReference type="GeneTree" id="ENSGT00940000154861"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000247">
        <property type="entry name" value="ADP-ribosylation factor-like GTPase 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="35"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="198"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="450" mass="49720" checksum="D6467AAF3EC452D3" modified="2019-02-13" version="1">AVKGPNFSQSFIYCCMGWAVCDCFLSTATSSTFVDSCNFEEENICGMIQGSGDAKWEQLASVAGGPETDFTNLGQCKGKGYFMHFSTASALPGERAFLESRWLYPKSGAQCLQFFLYNSGADDDVLNIWVREYDKANPNGKMKLFHSISGGVMGSWELHNINLNVTQKARVVFEGVRGMNPSKGGFSLDDINLSSTKCPHHIWHIRGINELLATTPAGKRMSSPRFMSPTGYTFQVGVYLNGQSSNPGYMAIYFHLTSGPNDDNLKWPCPWHQATMTLMDQQSDIRQHMNMNRMITTDPAKMSSDGTEFFWDNPKIVGSKITESDGSYYYRGPGFGTSSFITHDRLRSRYFIKGDDAFFLFSLEGEEAADQAAPQGAVNNTTVVIAIAGSVAGLMLVVSMLIVGKAWRTNKMKRQQEGVIIHNISGFVEVSTTKTESAHLQLLLCPFCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0M0</accession>
    <name>A0A3P9C0M0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0M0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015778"/>
    <dbReference type="Ensembl" id="ENSMZET00005016286.1">
        <property type="protein sequence ID" value="ENSMZEP00005015778.1"/>
        <property type="gene ID" value="ENSMZEG00005011840.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00880000138014"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF502">
        <property type="entry name" value="LYSOSOMAL PROTECTIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017849424" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="479" mass="54112" checksum="A395D4D59FC24758" modified="2019-02-13" version="1">MFLLPICYQMQLLLLSCYFLSAWLGVEAAPAADEITYLPGLQKQPSFKQYSGYLSVADGKHLHYWFVESQNKPSSDPLVLWLNGGPGCSSLDGLLTEHGPFLIQSDGATLEYNPYAWNKITNMLYLESPVGVGFSYSDDQKYATNDTEVSMNNYLALKEFFRLFPEYSKNELFLTGESYGGIYIPTLAERVMEDASLNLQGIAVGNGMSSYEMNDNSLVYFAYYHGLLGSHLWAVLQTYCCSNGKCNFYDNPNQNCMDSVGEVQTIVYSSGLNIYNLYASCPGGVPVERGQLVIRDLGNSFIHHQWNRLWILAALLPSVRLDPPCTNSTPSNLYLNNPLVRKALHISPKALDWVICSSEVNRNYGRLYMDVRKQYLKLLGALKYRILVYNGDVDMACNFMGDEWFVESLQQQVQVQRRPWIYEDVDGQQVGGFVKEFDNIVFLTVKVNATIIILTDCVMSCFGAGFCFKSAVFFHHRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C216</accession>
    <name>A0A3P9C216_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apoptotic chromatin condensation inducer in the nucleus</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005016162"/>
    <dbReference type="Ensembl" id="ENSMZET00005016677.1">
        <property type="protein sequence ID" value="ENSMZEP00005016162.1"/>
        <property type="gene ID" value="ENSMZEG00005012139.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00710000106790"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000147">
        <property type="entry name" value="Apoptotic chromatin condensation inducer in the nucleus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1484"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1551"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <begin position="1592"/>
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            <begin position="1629"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1643"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016162.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="1652" mass="187166" checksum="B6ABAAB2C05D422A" modified="2019-02-13" version="1">MADLEDVTLDGRPLQSLRVADLKAALEERGLSKSGQKNTLIKRLKGALMLENLQRTSTAHIGLQPNSQIGEEMSQNSFIKQYLAKQQELLRQRLEREAREAYDTNEQEEHAEVNNSTPCPPPAQDVTPALPEQHKPAGTSGEEGLLGAVNEGQANRNQEADMSSPPASGSVPMRVPAAEQRPERGSASSEVPGDSDDDDSEDGDEDGDDDDWDSSARRRNFREPARGPTTRERSAASRQPQQQHIPSLLSPQLRQPTPPPSPPPELSFPLPDTPKQSPPSPDVPQARRSPSSSSSGSSSGGSRSSSPEPQRSGHAERRPGPLTLLARKMESEGAFSGGGWHGTDGEADRQESNSSSATSFPGRGPPESLVSATTHTSNTAEHVPFPIMPGTNQGVTGAHSAHIQVPVSTLEPTVPDERVREMESDLERQEKLRKRRQERTAAEERERALALEREREQALERERFEQQQALEKEEREKALQKEKELALEKERQEREQALAKEREEQMRALELERQAELQRLKLLEQERLQREREEREKREREEMERAALERERERLERERALEAERIEREEALERERLEKEKALEQERIEREKALEQERIEREKALELERLEREKALELERREREKALELERLEREKALELERRERERVEREKALERERIEREKALERERVEKERAERRAALEQERIEKERKEKLERALQQEELERARKEMERALEQEREKALEHERLENEKAVQKEKEERERKLELEKDKTGVAEKESESHLSPSKCGLEAGLTPLPTPHPLSTGPAINSSAEAGDREQIRAPEPQSEGQAAECSATISTTSLSPHSSFKKFRFVMDRAQPSSTSMVIKRPRTFSDSPQPRTSPVTYPTTVGKGQSEGHRPSVKQEDSELRTNQQVAAAPPGSVRIQSEEDTAVITEMGPKEERATRLVLEDKEQAASGKTEQVAKESIKKVKEADESKGLSSSVSGAEQRGRDSKKERIRTRQRSSSDSSSSESDSGSSSSQSSGSSSSSQEKKNSTSRVTKEETSKRDSSTQHMAAQHEDVRKSSKTSTCKRETSAEKANTTADGDSHNVAQFSKAPTGEEKHGKRTDSEEEEEKDKQRQMKETTMADPEKFQETSEEKSKAFSARKISLSSSKSSPGTSSAEGEQESGTVAGRKRRWGSSTAVTAKKPSISITTDSLKSLIPDIRPCLGQEAVVDLHPEEAVLSGADDEDRERSDQDLQIRRTVTQVVHSESQENGQREAKRSRQEEAEEDDLQVDQERTKAHEEQMDTSIPVAVETHSPTHTSHDVEINTVTPSDTLIRRSISQQKTSVSITIDDPVRTAKQPSPPRGKVSTIVHICNLVRPFTLGQLKELLSRTGSLMEEGFWIDKIKSHCYVTYSSVEEAVATRAALHGVKWPQSNPKVLTVDFCQQDELDFHKGLGAGDKPGAEEHGPGSGRGRTSGLPSLLPERDQWAEREREMERRERARAEREWDRDKVREFGKHGEEKEGGPRRSRSRERRRKERGKSKEKKEKIAEDPPAKLLDDLFRKTKAAPCIYWLPLTDEQFAQREAARAERAKEREKRRKEQEEEEKKREEERKERVKTGGGTTERSEGEKDKDRERDRGRDRDRERERERENDKRRDGYRRPGGSGAGGGRRSRSRSEPRERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4Y0</accession>
    <name>A0A3P9C4Y0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4Y0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017104"/>
    <dbReference type="Ensembl" id="ENSMZET00005017650.1">
        <property type="protein sequence ID" value="ENSMZEP00005017104.1"/>
        <property type="gene ID" value="ENSMZEG00005012850.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164039"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03117">
        <property type="entry name" value="alpha_CA_IV_XV_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.200.10:FF:000003">
        <property type="entry name" value="Carbonic anhydrase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041874">
        <property type="entry name" value="CA4/CA15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF200">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017994196" description="carbonic anhydrase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="314" mass="34359" checksum="1F7D53E180DB056B" modified="2019-02-13" version="1">MEWFKVVAFVVCVLPTAHCASDSIAWCYHLPSCNDTTWPRISPQYCSGSRQSPINIVSASATPNDKLTEFTFFKYDNTSAMTSIENTGDTVKVTLKSGVKISGGDLSEQYDSLQFHLHWGNGSSVPGAEHTVDGKRYPMELHIVNSKSSYNGNTNLAVKDSTGLSALGFFIEVMSGNSTGQPDSWHNLASYLPNITEKGQNVSIAAGFSLDDLLVGVDRTKYYRYLGSLTTPACQEAVVWTVFKEPIKVSKDLIDLFSTTLHFNDSSSPIMINVYRSLQPAQKVWTQSIKASASTTCFSLSLLLLSLVLGSSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C545</accession>
    <name>A0A3P9C545_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Potassium voltage-gated channel, KQT-like subfamily, member 5b</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C545"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017026"/>
    <dbReference type="Ensembl" id="ENSMZET00005017570.1">
        <property type="protein sequence ID" value="ENSMZEP00005017026.1"/>
        <property type="gene ID" value="ENSMZEG00005012772.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155933"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000017">
        <property type="entry name" value="potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000016">
        <property type="entry name" value="Putative potassium voltage-gated channel subfamily KQT member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF8">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="109"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="17">
        <location>
            <begin position="429"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="17">
        <location>
            <begin position="586"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="385"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="683"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="921"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="988"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="715"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="988"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1043" mass="113492" checksum="22B6EF1DA5647476" modified="2019-02-13" version="1">MPRNHSGDEGGTGLWMRTSPGHRTEGYGLKDVESGGKMMNNAGDGLLSAPGAAGAAGSDNARGKQGARLSLLGKPLLYSTQSGRRNVRYRRLQNYLYNVLERPRAWAFIYHAFVFVLVFSCLVLSVFSTIPAHQEFSSYCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDIIVLIASVAVVSAGSQGNIFATSVLRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLVLIFSSFLVYLVENKFNNEFATYADALWWGTITLTTIGYGDKTPKTWTGRMLSAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAYLIQCVWRSYAADENSVSIATWKPHLKALHTCSPTKKEQGESTTSQKLSFKERVRMASPRGQSIKNRQTSSVNDRRSPVADAGTEGTSPAKVQKSWSFNDRTRFRPSLRLKSQSRSTTDDSNITAEDGFDEKGCHCDISVEDLQPSVKSVIRAVRIMKFHVAKKKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRLDMIVGPQPLSSRAKAFSSPSLSVYYSQGRKNSTQGVDQILGKGQIPLDKKIRDKLLSDGDILEDMSMLGRVCKVERQVQSIESKLDSLLDIYRQVLRKGSSSALTLSSLPLFELEQTSDYHSSVFSKDMSCSTQVSSSGAPPTSGFVTRSSTSSHLSQGGLHLILGPPNELNLNLNAPSSTPPSGLASSSFSPSPLPHHHHHRHHHHPQAQATTPESGTDEAMGSSPPILTPNSVSSSGDRGVRDGGFPLLARLPPPPPPSRSHGPGTLVRTASIEVSPDIEDFCGGLGTQMEDSVVGKGLGLGLNRLGQQLQGNSNSRLSTKEEGSWRRQMSLELEPLVPPALGCSSGSNEMDRGLGKSMSVQDLKQVAPTHHGHSLSSPSPSTSSDSPIGFHSCSQDPGGGGGGTGRRSGGGWGEEDLFISDRDIETQGLDFLSQGSAETPTYSSELLRTGGRAGAGTQGSNRSLASGHASLPSTGSNELLNMPHVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C5C3</accession>
    <name>A0A3P9C5C3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloproteinase inhibitor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tissue inhibitor of metalloproteinases 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559483.1">
        <property type="nucleotide sequence ID" value="XM_004559426.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C5C3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017480"/>
    <dbReference type="Ensembl" id="ENSMZET00005018037.1">
        <property type="protein sequence ID" value="ENSMZEP00005017480.1"/>
        <property type="gene ID" value="ENSMZEG00005013156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467613"/>
    <dbReference type="KEGG" id="mze:101467613"/>
    <dbReference type="CTD" id="406650"/>
    <dbReference type="GeneTree" id="ENSGT00940000158348"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
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        <property type="term" value="C:extracellular matrix"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protease binding"/>
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        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
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        <property type="term" value="P:response to cytokine"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:response to hormone"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NTR_TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.370.10:FF:000001">
        <property type="entry name" value="Metalloproteinase inhibitor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.370.10">
        <property type="entry name" value="Tissue inhibitor of metalloproteinase-1. Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
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        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027465">
        <property type="entry name" value="TIMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030490">
        <property type="entry name" value="TIMP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF24">
        <property type="entry name" value="METALLOPROTEINASE INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00288">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="5" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="6" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018111754" description="Metalloproteinase inhibitor 2" evidence="15">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="16">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="site" description="Involved in metalloproteinase-binding" evidence="13">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="site" description="Involved in metalloproteinase-binding" evidence="13">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="159"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022608"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023215"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="220" mass="24936" checksum="C2C3ED75BF2403AD" modified="2019-02-13" version="1">MTWTMKRCFVTLAILCLWRVQQLAEACSCSPRHPQQVFCNSDVVIRAKVVGKQEVDVGNDVYGDSIKRLKYDIKQIKMFKGPSNAIDAFYTARSSAMCGVSLETDGRKEYLITGMLEADGTMHVTLCGLFEPWDNLTTTQKMGLTERYQMGCECRITSCSSIPCMINSPSECLWLDWLMEKTENGRQAKHYACIKRSDNSCAWYRGSAAPKKDFMDIEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C5K6</accession>
    <name>A0A3P9C5K6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transducin-like enhancer protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C5K6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017181"/>
    <dbReference type="Ensembl" id="ENSMZET00005017727.1">
        <property type="protein sequence ID" value="ENSMZEP00005017181.1"/>
        <property type="gene ID" value="ENSMZEG00005012901.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234519"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000001">
        <property type="entry name" value="transducin-like enhancer protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF31">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="14">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="542"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="584"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="159"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="742" mass="80289" checksum="3B1B664C9269D65F" modified="2019-02-13" version="1">MIRDLSKMYPPARHPVPHQPGQPFKFTVTESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMVRQLTSCVAISILLAEIVKRLNAICAQVIPFLSQEQQQLQAQHLSHGHAIPVPLTPHPAGLQPPLPPGASTASLLALSSALSHQLPLKDERKHHDNNSEHTRGESSSVSPSANFRTGEKHRSSSDYSSDSKKQKTDDKELTSTRYESDGEKSDDNLVVDVSNEDPVSPRGSPAHSPRENGLDKSRLLKKDPPLSPSSIASSSSTPSSKSKDINMNEKSTTPVSKSSTPTSRSEAPTPSSASTTGLRSAPSKSSGVEALTPGLRTPLAVPCSYPGPFGMVPHPGMNGELSGTGAAYTGLHNISPQMSAVAAAAVAAYGRTQVVGFDPHHHIRVPGLPPNLSGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLTHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKTPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLATPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLNNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLRFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISIDDKYIVTGSGDKKATVYEVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C624</accession>
    <name>A0A3P9C624_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop. Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus.</text>
    </comment>
    <comment type="function">
        <text evidence="13">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with NOL8; the interaction is RNA-dependent. Interacts with PRC2 complex components EZH2, SUZ2 and JARID2; these interactions prevent deposition of the repressive H3K27me3 mark onto rDNA in pluripotent cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C624"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017552"/>
    <dbReference type="Ensembl" id="ENSMZET00005018116.1">
        <property type="protein sequence ID" value="ENSMZEP00005017552.1"/>
        <property type="gene ID" value="ENSMZEG00005013189.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00680000100037"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="150"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="339"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="611" mass="69115" checksum="654BA653EAB2BA8B" modified="2019-02-13" version="1">MADLQMKLLRKKIQKRNEKDRERKLQKKKREDEVTGEDGEEGEDGEFCFVGASVNVHVLIEAVKKSKTAKEEENGEEDTEEEEVADDNGDAAADKPQEEEEDEPELPCGLTGAFEDTSFASLASIVSENTLKGVKGMGFEHMTEIQHKSIRPLLEGRDVLAAAKTGSGKTLAFLIPCIELIYKLKFMPRNGTGVIILSPTRELAMQTYGVLKELMTHHVHTYGLIMGGSNRSAEAQKLANGVNIVVATPGRLLDHLQNTSGFMYKNLQCLIIDEADRILEVGFEEELKQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKEPLYVGVDDNKDKATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKLMVFFSSCMSVKFHYELLNYIDLPVMAIHGKQKQTKRTTTFFQFCNADSGILLCTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGIDGRGHALLILRPEELGFLRFLKQAKVPLSEFEFSWSKISDIQSQLEKLIEKNYYLHKSAQEAYKSYVRAYDSHSLKQIYNINTLNLPMVALSFGFKVPPYVDLNVHSSKGAKLQKRGGGGGFGYQKSKNVQKSKIFKHVNKGKSDRRQFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C671</accession>
    <name>A0A3P9C671_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acidic leucine-rich nuclear phosphoprotein 32 family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Multifunctional protein that is involved in the regulation of many processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C671"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017554"/>
    <dbReference type="Ensembl" id="ENSMZET00005018118.1">
        <property type="protein sequence ID" value="ENSMZEP00005017554.1"/>
        <property type="gene ID" value="ENSMZEG00005012845.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182907"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000003">
        <property type="entry name" value="Acidic leucine-rich nuclear phosphoprotein 32 family member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF1">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="251" mass="28851" checksum="ADC409171891BD81" modified="2019-02-13" version="1">MDMKKRIHLELRNRTPSDVKELVLDNCRSNEGKIEGLTDEFEELEFLSTINVGLTTVAHLPKLNKLKKLELSDNRISGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKELGTLKSLDLFNCEVTNLNEYRDNVFKLLPQLTYLDGYDKDDKEAPDSDAEVYAEGLDDDEEDEDVDDEEYDEDAAPGDEEEEEGEDEEEENEEEEEEDLSGEEEEEDDLNDREVDDEDDEEERGQKRKRDLDEEGEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6R3</accession>
    <name>A0A3P9C6R3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Carboxypeptidase A1</fullName>
            <ecNumber evidence="15">3.4.17.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.</text>
            <dbReference type="EC" id="3.4.17.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.1" evidence="15"/>
    <dbReference type="RefSeq" id="XP_004556376.1">
        <property type="nucleotide sequence ID" value="XM_004556319.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C6R3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017792"/>
    <dbReference type="Ensembl" id="ENSMZET00005018375.1">
        <property type="protein sequence ID" value="ENSMZEP00005017792.1"/>
        <property type="gene ID" value="ENSMZEG00005013375.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466908"/>
    <dbReference type="KEGG" id="mze:101466908"/>
    <dbReference type="GeneTree" id="ENSGT00940000158082"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03870">
        <property type="entry name" value="M14_CPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000132">
        <property type="entry name" value="Carboxypeptidase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000001">
        <property type="entry name" value="Carboxypeptidase A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034248">
        <property type="entry name" value="CPA_M14_CPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF94">
        <property type="entry name" value="CARBOXYPEPTIDASE A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018024660" description="Carboxypeptidase A1" evidence="18">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="19">
        <location>
            <begin position="128"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="425" mass="48089" checksum="B3B16D3C1926FA79" modified="2019-02-13" version="1">MLATMRKLLAFAVLFVAVLGKETFNGHQVLRLVPKSDGHLSLIKDLHNMIEQELDIWREVSDVGFPVDIRVPVHQLKMVKRYLKAYDIQFSTMIKDLQVLLDEEQKAMESALAHVPEPRNTDNFDFSSYHNLSEIYSFQDMLVAENPNLVSKIVIGQSYEDRPLNVLKFSTGGTNRPAIWIDTGIHSREWVTQASGLWFAQKIVTDFGRDPKLTAVLNQMDIFLEIVTNPDGYAFTHTNSRMWRKTRKPNPGSLCVGVDPNRNWKAGFGGPGSSGNPCSQTYRGPRAQSESEVNSIVRFVNSHNIKAFISIHSYSQLLMFPYGYTRTPIKDYTELDNLAQKAVTDLASLYGTSYKFGSIINAIYQAGGGSIDWAYNQGIKYSYTFELRDTGRYGFLLPASEIIPTAQETWLALMTIMDHTLKNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C950</accession>
    <name>A0A3P9C950_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NOP9 nucleolar protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004565394.2">
        <property type="nucleotide sequence ID" value="XM_004565337.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C950"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018803"/>
    <dbReference type="Ensembl" id="ENSMZET00005019407.1">
        <property type="protein sequence ID" value="ENSMZEP00005018803.1"/>
        <property type="gene ID" value="ENSMZEG00005014104.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101483729"/>
    <dbReference type="CTD" id="161424"/>
    <dbReference type="GeneTree" id="ENSGT00390000004964"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="613" mass="68099" checksum="DC1B2611159C93E5" modified="2019-02-13" version="1">MLSKAEDKKPQKGGGKKRRHPGEDGGGERKRRESPKGEKGQGGKKRLDALSVGYFRRVGERLSEGFEDDEEREMFVENVLTEAKGKAALVATDRTGSITLQRLLPLSSPQQVGEVLAELGGESGSEFKAVSCDRCGGHVVESAVRQMSRWMESSEKESSPPTEEEGEESCGLLEAQVLSFSQVVRDNAAEFIRHVHGSHVVRTLLHVLGGCLGPPRTETRPGGKERSIPPQLTDFEIPTSFWYELKDLTETLMENINLSVTDAVASAVFQTMLTVCHRKRPKLCKQLLRRIMEYLTSRSAAPGVSPLLVFLKDQASSRLIETIIQLSHKPLLRGLYKNHLKGQLVDLALHPIANFPIQRLTAASAKYKLFLRIFDELFQGVEAILAAGHMGVIVQLAESCAESEERQDEMMQCLLNAFHCAEPGSRHVACLPLFMSLLTYEVYYHSDTAEGNISTEIPLTSICYHGSRLVQALAKFKERSLLLSSLRTLSPSDLLSMATDPAGSHVLQALITTSSDKGRGKILKRLEGQYVQMACSRLGSRVLEAVWNSSSVGQRQSMAQELVPSESQLRADQFARHVWAKFALSHFAHRRAHWQEIQTGESKKRKLFSDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C958</accession>
    <name>A0A3P9C958_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">GPI inositol-deacylase that catalyzes the remove of the acyl chain linked to the 2-OH position of inositol ring from the GPI-anchored protein (GPI-AP) in the endoplasmic reticulum. Initiates the post-attachment remodeling phase of GPI-AP biogenesis and participates in endoplasmic reticulum (ER)-to-Golgi transport of GPI-anchored protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C958"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018637"/>
    <dbReference type="Ensembl" id="ENSMZET00005019237.1">
        <property type="protein sequence ID" value="ENSMZEP00005018637.1"/>
        <property type="gene ID" value="ENSMZEG00005013978.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016484"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24660">
        <property type="entry name" value="PGAP1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="118"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="12">
        <location>
            <begin position="551"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="823" mass="92654" checksum="892E17D4E64174F2" modified="2019-02-13" version="1">MKLAAVAFYGLAAGLLAVGLRELLTGFEENRCSMTYMFEYPEYRRVALPRRVARLYPAYGLYLYGEGVYAQETRALKLTGAPVLFLPGNAGSYKQGKSAKLIMVQCLHLNYHERLLSRRFLHESIKAILRLYKTPPQSVVLVGHSMGGVVARIIITQASPHLAPVLALDPYLLGKSWSNLLSSTRMSQFVRRGGYRDYQVRSGLTSCRSPGPDKLSLVYDLLLKSFNSAVFLWCKELVLATVRAFFDLIDPETRQFTENSEKKLAVLNHHFIKHPVRLPGETQETPVSISDLPDAWSEVNTLRLAYSTPKEGQPKFFLFALSSRRKAYSHFYCRSNNLVSYYLFVFAADLSKGTELLPPYKSLSHQLGRSQTNKPPFFKELVKVVCLSALQFTVECEWQREESQTLSVAVPHVLSFGLTSSDVTVNSSGLLHTIELQHFHQVYQAFRINVASQCKVQKGECVLLDQEAHVLMLLPSVYRIKVPWFREDSLTTVSVPSVTEISGMLHTSRPDNTSGALLQLHTAPNCQYKVSIRTSLPRVLGQILRFCGHMVPVYTAVTLLLACGGQVSSILKSRRAADMSQMVGKGLQPHKVNLPVYILHIALSCSCFQEVWSMLFLPSMDTLPPTFLDVAFHEEETPGEEWVHLLSPLLYIFGAAVAYWGSALLRLVIRLISLVLAPLHRPSVSRDCGTLRLRTQLLITLCLTVMGGTSCGALSIFASFLFHLYRVNIDLIKLFIILLKQRHPLLSECALQEVRDDLQLHLCLSALFTLPVMLSGPSLIHWIRNLRYVFHPAESDPCWPYIVPLIFVYMLLINCNTLKLSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C963</accession>
    <name>A0A3P9C963_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LRRFIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C963"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018642"/>
    <dbReference type="Ensembl" id="ENSMZET00005019242.1">
        <property type="protein sequence ID" value="ENSMZEP00005018642.1"/>
        <property type="gene ID" value="ENSMZEG00005013996.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063564"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019139">
        <property type="entry name" value="LRRFIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212">
        <property type="entry name" value="LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212:SF5">
        <property type="entry name" value="LEUCINE-RICH REPEAT FLIGHTLESS-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="151" mass="17811" checksum="3C9277C614854E5D" modified="2019-02-13" version="1">MHQPQPPPYHLSGSSHPWYVILFSFLRWNKVVVIIKQLQICCDSFFFFFFFFFFNLKHVQISELKFKLVKAEQEATALEQNVTRLEGQVTRYKSAAENAEKIEDDLKAEKRKLQRELRSALDKIEELESNNSHLSKRLEKMKSSRGMAQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9Y1</accession>
    <name>A0A3P9C9Y1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phospholipase A and acyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9Y1"/>
    <dbReference type="Ensembl" id="ENSMZET00005019708.1">
        <property type="protein sequence ID" value="ENSMZEP00005019095.1"/>
        <property type="gene ID" value="ENSMZEG00005014325.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156634"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="F:N-acyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
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        <property type="entry name" value="H-rev107_PLA/AT"/>
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        <property type="entry name" value="LRAT_dom"/>
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        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
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    </dbReference>
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        <property type="entry name" value="HYPOTHETICAL LOC794087"/>
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        <property type="entry name" value="LRAT"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="5">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="155" mass="18163" checksum="85A098D540CB2F4E" modified="2019-02-13" version="1">LGLGNTCFIRPELFPGDIVEYPRNKYFSHFGVYYGERDGVPYVAHLTCRDSDTKLLLYGRALRSEVKLDPLELLGKKYKVNNMLDDTHPPRDFHGVVKPAIEDMMGREVTFDILFHNSEHQATLFRYGVKKSEQIDEIYEYIMPAWKKLFKEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CA14</accession>
    <name>A0A3P9CA14_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tripartite motif-containing protein 16</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CA14"/>
    <dbReference type="Ensembl" id="ENSMZET00005019490.1">
        <property type="protein sequence ID" value="ENSMZEP00005018884.1"/>
        <property type="gene ID" value="ENSMZEG00005014164.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286950"/>
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        <property type="component" value="LG7"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19802">
        <property type="entry name" value="Bbox1_TRIM8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16543">
        <property type="entry name" value="RING-HC_TRIM77_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16040">
        <property type="entry name" value="SPRY_PRY_SNTX"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
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        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="302"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="490" mass="56264" checksum="A0A1B8C9FA0F8180" modified="2019-02-13" version="1">MAQQGIQLDQDKLCCSICLDLLKDPVTIPCGHNYCMNCIKCCWDRGDLREIPCCPQCRQAFIPRPALVKNTMLAELVEELKKSGLQAPPADHCDAGSEDVACDFCIGEKMKAVKSCLQCLVFYCEQHLQPHYESPAFKKHKLVDPSQMRIICPRHNEVMKIFCRTDQQCICYLCSMDEHKGHCTVSAEAERKERQKALGASHEKLQQRLQEREEAKRVFQQEVEAINHSADKAVRCSETIFTELIKTIEKRRSDVTQQIRLQQKTEVSRVKELQEKLQQEISELRRRNTELEQLFHTEDHTQFLCTYTSLSHIMSEVDVLLPQPDPKTRATFLQYSCQLTLDQTAVQLAVDLYANKPESHAFTNRFQVLSRETLTGRCYWEVEWSGGGVTVAVTYRDISRKQQEESEFGHNDKSWALQCVDQRCFFKHNKRKTPISVCRPSRVGVYLDHRAGILSFYRVSGTMTLLHRVQTTFTQPLCAGLGLDMGSTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAN0</accession>
    <name>A0A3P9CAN0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonucleoside-diphosphate reductase subunit M2</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ribonucleotide reductase small chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribonucleotide reductase small subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004561165.1">
        <property type="nucleotide sequence ID" value="XM_004561108.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAN0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019064"/>
    <dbReference type="Ensembl" id="ENSMZET00005019677.1">
        <property type="protein sequence ID" value="ENSMZEP00005019064.1"/>
        <property type="gene ID" value="ENSMZEG00005014295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469208"/>
    <dbReference type="KEGG" id="mze:101469208"/>
    <dbReference type="GeneTree" id="ENSGT00390000013305"/>
    <dbReference type="OrthoDB" id="8389495at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF20">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="385" mass="44381" checksum="BF3261B88CAD392A" modified="2019-02-13" version="1">MLTARSPLSVKNEQTLSGQLDKMSLDKENTPPGPNSSRILASQTARRIFDAAAPKVKKSSSSQEEEPLLKDNPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDLQHWDAMKDEERYFISHVLAFFAASDGIVNENLVERFMQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETLPCVKKKADWALNWIGNKNATYGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVNKPPKETVISIIKNAVEIEQEFLTDALPVKLIGMNCDMMKRYIEFVADRLLLELGFSKIYRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMATPTDNTFRLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBG4</accession>
    <name>A0A3P9CBG4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 13">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="10 13">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="10 13"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBG4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019339"/>
    <dbReference type="Ensembl" id="ENSMZET00005019965.1">
        <property type="protein sequence ID" value="ENSMZEP00005019339.1"/>
        <property type="gene ID" value="ENSMZEG00005014510.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063646"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 13" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="648" mass="71122" checksum="F432DB1E06DC14D2" modified="2019-02-13" version="1">MLVRTARLFPFIISHHLHPSRTHSAGHGFRWSAAAASRGVRFMETEVPASNPPAASAEDSADGTGQSATISTGDQEKMPSVGLLPGETVVKEGKAAILFPSANEVFYNPVQEFNRDLTCAVITEFARELLAQRGVKVVVPGEQERVVVSLSEETNEAEAQTEEKNGSEEPAVTAAAGERCERGLRVLEGLAASGLRSVRFALEVPGLQSVTANDFSAKAAALIARNAQYNGVSHLLQASCRDASMLMYDMRAKKDRYDVIDLDPYGSPASFLDAAVQSVSEGGLLCITCTDMAVMAGNSGETCYSKYGSVSIKAKYCHEMALRIILHSLDQRAGVYQRYIQPLLSVSVDFYIRVFVRVFTGQATVKNSASKQALVYNCVGCGAFHLQRMGRRTSNGKHMKYSAATGPPVGPECEHCGQRHQLGGPIWAESIHDLEFVQKVLSAVLGNPCRFGTSKRIEGVLSMVTEELEDVPLYYTVDNLSSTMHCNTPSLLQFRSALLHAGHRVSLSHACKNAIKTDAPPAAIWDIMRCWVNFTGEKEKLFFVILNTACFTVREDANPQSRKRHLTRFQENPQAFWGPKARAKAGGGISADLQDKRKKFQNKRKNQITDSSQLKTFPCKKFKQGTCTHGDECCYFHDSEQTNEQKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CC66</accession>
    <name>A0A3P9CC66_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Paired box protein Pax-9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CC66"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019717"/>
    <dbReference type="Ensembl" id="ENSMZET00005020348.1">
        <property type="protein sequence ID" value="ENSMZEP00005019717.1"/>
        <property type="gene ID" value="ENSMZEG00005014778.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159896"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048593">
        <property type="term" value="P:camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030902">
        <property type="term" value="P:hindbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045658">
        <property type="term" value="P:regulation of neutrophil differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000084">
        <property type="entry name" value="paired box protein Pax-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF13">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="10">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="342" mass="37416" checksum="F3E39481EA453A96" modified="2019-02-13" version="1">MLTETQINYQHILNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKFNLPSVSSISRILRNKIGNLSQQSQYESGKQAPHPPPQPTLPYNHLYSYPTSKVPTPPGMPTLPGHMAMHRIWPSSHSVTDILGIRSITEQQISDSPSFPSTKLEEWSAINRTNFLPASSPLVNGVDKAHLEPEAKYTQMPNGLPTVNSYVTAPSIPPYHPPTQVSPYMGYSATTSAYVTGPTWQPASGNALSPHSCDIATPLAFKRMSANRDAIHPVAASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDS3</accession>
    <name>A0A3P9CDS3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDS3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020189"/>
    <dbReference type="Ensembl" id="ENSMZET00005020841.1">
        <property type="protein sequence ID" value="ENSMZEP00005020189.1"/>
        <property type="gene ID" value="ENSMZEG00005015149.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164656"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001935">
        <property type="term" value="P:endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF7">
        <property type="entry name" value="SI:DKEY-228B2.6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="216" mass="25493" checksum="96671237A5929099" modified="2019-02-13" version="1">LPTWVTKFNGILSFHGFPTHSDLRRQWLVNIRRDHFTITSHTRLCCRHFASDQLIEPTTLDGRRRLIKGAVPTLFEWNGYKVEPPRRSVWERTERRPELVRLTRDHDYCSVPEPSALDISASAAEDLFKDVETLRKEIQELRVQREFGLQRFAVTCNNKIIHEIHSSLKDLFFFLLCFHCSFFQTQVSWHIYVKKEIVCLSSGCIVHICIHVYCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF79</accession>
    <name>A0A3P9CF79_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Katanin p60 ATPase-containing subunit A1</fullName>
            <shortName evidence="11">Katanin p60 subunit A1</shortName>
            <ecNumber evidence="11">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">p60 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KATNA1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
            <location evidence="1 11">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Microtubule organizing center</location>
            <location evidence="11">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004566301.1">
        <property type="nucleotide sequence ID" value="XM_004566244.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004566302.1">
        <property type="nucleotide sequence ID" value="XM_004566245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CF79"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020689"/>
    <dbReference type="Ensembl" id="ENSMZET00005021370.1">
        <property type="protein sequence ID" value="ENSMZEP00005020689.1"/>
        <property type="gene ID" value="ENSMZEG00005015520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484367"/>
    <dbReference type="KEGG" id="mze:101484367"/>
    <dbReference type="CTD" id="11104"/>
    <dbReference type="GeneTree" id="ENSGT00940000156638"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21748">
        <property type="entry name" value="Kp60-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19522">
        <property type="entry name" value="RecA-like_KTNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000025">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000003">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000159">
        <property type="entry name" value="Katanin p60 ATPase-containing subunit A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03023">
        <property type="entry name" value="Katanin_p60_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028596">
        <property type="entry name" value="KATNA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048611">
        <property type="entry name" value="KATNA1_MIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048612">
        <property type="entry name" value="KTNA1_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF71">
        <property type="entry name" value="KATANIN P60 ATPASE-CONTAINING SUBUNIT A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21126">
        <property type="entry name" value="KATNA1_MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="238"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="80"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="488" mass="55622" checksum="15F2FA740A244C8B" modified="2019-02-13" version="1">MSLREISENLKLAREYALLGNYSSASVLYHGLLEQIKKYVYTLRDSSFQQRWQQLWQEIIEENQQVQDIMSTLGNFQLDTAPVKPSNHDDFETRPLHVEQRHSPCPVRRPTNPYKDSKPANNRLSVAVKAQQRHLPRGANGDRSRPSKGKEKKEPKEAAGKAKDDKNKSDVQEKEAKRFDGAGYDKDLVEALERDIISQNPNIKWDDIADLEDAKKLLKEAVVLPMWMPAFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECRTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSMCSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSTKGRVELLKINLRELELASDVDLDKIAEQMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNISRDEMHMPTTMEDFESALRKVSKSVSAADLEKYEKWIEEFGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF88</accession>
    <name>A0A3P9CF88_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
            <ecNumber evidence="11">3.1.3.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Protein-tyrosine phosphatase mitochondrial 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:75163"/>
            <dbReference type="ChEBI" id="CHEBI:78907"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:42305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42584"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82605"/>
            <dbReference type="ChEBI" id="CHEBI:82606"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:42585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65221"/>
            <dbReference type="ChEBI" id="CHEBI:78911"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:42309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:33752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78930"/>
            <dbReference type="ChEBI" id="CHEBI:78931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42321"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Interacts with STYXL1; the interaction inhibits PTPMT1 catalytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004566405.2">
        <property type="nucleotide sequence ID" value="XM_004566348.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CF88"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020940"/>
    <dbReference type="Ensembl" id="ENSMZET00005021627.1">
        <property type="protein sequence ID" value="ENSMZEP00005020940.1"/>
        <property type="gene ID" value="ENSMZEG00005015728.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101466005"/>
    <dbReference type="CTD" id="114971"/>
    <dbReference type="GeneTree" id="ENSGT00390000014065"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14524">
        <property type="entry name" value="PTPMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000060">
        <property type="entry name" value="Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042165">
        <property type="entry name" value="PTPMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044596">
        <property type="entry name" value="PTPMT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712:SF1">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018273328" description="Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1" evidence="23">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="24">
        <location>
            <begin position="28"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="25">
        <location>
            <begin position="100"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00055472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="182" mass="20722" checksum="C7FFAAA0B2825F4A" modified="2019-02-13" version="1">MSGVLARLLFYPTLAYNVVMEKVSSRRWFDRVDETVILGALPFRSMTKQLVETENVRGVITMNEEYETKYFCNSAQEWQAAGVEQLRLSTVDLTGVPSMENLHRGVEFALQHKEQGTSVYVHCKAGRSRSATLAAAYLIQLHCWTPDEACQKLASVRPHILVRSAQLEMLRKYYQQICAQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGN6</accession>
    <name>A0A3P9CGN6_9CICH</name>
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        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGN6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021458"/>
    <dbReference type="Ensembl" id="ENSMZET00005022167.1">
        <property type="protein sequence ID" value="ENSMZEP00005021458.1"/>
        <property type="gene ID" value="ENSMZEG00005016114.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157212"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008356">
        <property type="entry name" value="Tyr_Pase_KIM-con"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198:SF2">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01778">
        <property type="entry name" value="KIMPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="123"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="273"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="296"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="363" mass="40488" checksum="F40C647F8039C371" modified="2019-02-13" version="1">PTPVPIIGSNNHTPPPSVTPVTSNNELKPCPSPFRMKPAAGLQERGSNVSLVLDMSALGTVEPLNVAVVTPREAVAREYLLSAGRPLTRQQLRDIVNNTHRLHAEFAQEIPMNFIDPKELDIPNHGTKNRYKTILPPHSRVILKSKSSNDLLSTYINANYIRGYLGDDKAYIATQGPMVNTVNDFWQMAWQEESPVIVMITKLKEKNECVLYWPEKRGIYGKVEVLVNSIRECEHYTTRSLTLKCGNQTRSVQHYWYTSWPDHKTPVSALPLLQLMTDVETDRRAATNVGPVIVHCAGIGRTGCFIATTMGCRQLQLEGVVDVLGITCQLRADGGMIQTGEQYEFVHHALSLYEARLCAETGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGU3</accession>
    <name>A0A3P9CGU3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ral guanine nucleotide dissociation stimulator-like 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004568611.1">
        <property type="nucleotide sequence ID" value="XM_004568554.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004568612.1">
        <property type="nucleotide sequence ID" value="XM_004568555.2"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005021513"/>
    <dbReference type="Ensembl" id="ENSMZET00005022223.1">
        <property type="protein sequence ID" value="ENSMZEP00005021513.1"/>
        <property type="gene ID" value="ENSMZEG00005016157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463702"/>
    <dbReference type="KEGG" id="mze:101463702"/>
    <dbReference type="CTD" id="5863"/>
    <dbReference type="GeneTree" id="ENSGT00940000167370"/>
    <dbReference type="OrthoDB" id="26687at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17211">
        <property type="entry name" value="RA_RGL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF350">
        <property type="entry name" value="RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="102"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="261"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="625"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="743" mass="83037" checksum="C77605811BA76486" modified="2019-02-13" version="1">MLPRNIRTGGYNLPGVESDNVPLIGFRPLSPDRGTISGHSGRRAADAEVQSSQAEPSPMKTTWYCPLDLPTVVEEEEDGVIYTVTVKQHHGGPNSPMSTVSKSQCVKAGTEEKLVLHLLHSFCMGDSSFITIFLSTYRSFTTTGRVLDILSDRLENPPGDSERSQIRQSFNKAVCTVFSTWLSEYPEDFKSLGDPSRLLRLAPLLPHDSSSAADLRARFLRIAEELSEKALLPDTHKDQTSFTSPPPDASKFEPTSILGFSGALIAEQLTMIETELFVRLVPYHCLGSLWSQRDKKGREGVCWSVRATVRQFNKLANAVLASCLWPTKLRSQQRARLLEKWISVAEACRARKNFSSLYAIVSALKSNPIHRLRKTWQDTDREALRKYEELSEIFSDKDNYSQTRELLKEEGTSKFANLENRLNNRYLNKSNAQGTVPYLGIFLTDLTMLDTAVKDRLDNGYINFDKRRREFEVLAQIRLLQSSCKNCVFTADEAFVQWYNSVPTLREEESYRLSNEIEAPGDPSPRGHAPAVVITQCPDLSTSRTSLAGDSDSFFDFHSPVNNLLSKLTKHMRSPSVSCLDVDTSPPTNESNPATLTPTTPTKSHRRSASCGNNPPGNIQGSGADMRIIRIRMDLEDGNLYRSILVTSNDKTPTVISSALEKHNQDPKQASRYELIQLLPEGKELVIPATGNVFYAMTSSSVDFLLRRKDGNSPFGSHPISTETSATFPRIKAKGRRLVRNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CI45</accession>
    <name>A0A3P9CI45_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WW domain-containing adapter protein with coiled-coil</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004572320.1">
        <property type="nucleotide sequence ID" value="XM_004572263.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CI45"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021827"/>
    <dbReference type="Ensembl" id="ENSMZET00005022542.1">
        <property type="protein sequence ID" value="ENSMZEP00005021827.1"/>
        <property type="gene ID" value="ENSMZEG00005016365.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482307"/>
    <dbReference type="CTD" id="323904"/>
    <dbReference type="GeneTree" id="ENSGT00440000037780"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000020">
        <property type="entry name" value="WW domain-containing adapter protein with coiled-coil isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038867">
        <property type="entry name" value="WAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15911:SF6">
        <property type="entry name" value="WW DOMAIN-CONTAINING ADAPTER PROTEIN WITH COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="543" mass="59124" checksum="4C48F81DA68A8058" modified="2019-02-13" version="1">MVMYARKQPRLGDGCDRRDSQPYQTLKYSSKSHPGGDHRHDKMRDSSDVTPPCKMLRRSDSPENKHIDSTGHSRAKGVHTHRARDRDGGTSYSPQENSHNHSSLHSSNSHSNPSKTSDTPYEPGDDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEATKTAVVNSFPKDRDYRREAMQASAAPGFTGPKSAQVEKPAAALATQSQSSSGSGSLNPSSGPPGSSASTVPVSPVLQSPAPPLLQDPTLLRQLLPALQTALQLNNASVDMAKINEVLTAAVTQASLQSMLHKILTAGPSAFNITTILSQAAQLSNQAQQSNQSPMSLTSDASSPRSYVSPRISTPQTNAGPLKPLLSTQPVITQPKVSTPSAKQASHPQPTSQQPLSSDKQHSYDATTSSPRTLQRQGSQRSPSPGPNHVASSSSNASNSASAPPAPSAARPSCSFTPTLAAHFNENLIKHVQGWPAEHAEKQASRLREEAHTMGSICMSENCTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJ82</accession>
    <name>A0A3P9CJ82_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyroglutamyl-peptidase I</fullName>
            <ecNumber evidence="10">3.4.19.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="10"/>
    <dbReference type="RefSeq" id="XP_004564848.1">
        <property type="nucleotide sequence ID" value="XM_004564791.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJ82"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021896"/>
    <dbReference type="Ensembl" id="ENSMZET00005022613.1">
        <property type="protein sequence ID" value="ENSMZEP00005021896.1"/>
        <property type="gene ID" value="ENSMZEG00005016414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482568"/>
    <dbReference type="KEGG" id="mze:101482568"/>
    <dbReference type="GeneTree" id="ENSGT00390000015368"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.20:FF:000002">
        <property type="entry name" value="Pyroglutamyl-peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="210" mass="23058" checksum="C46FF365C22C7837" modified="2019-02-13" version="1">MDNSKRAVVVTGFGPFGEHTVNASWVAVQELKKLGLGSDVNLHVHEVPVEYQQVQSLVPSLWKQYHPRLVVHVGVSGMATTVTLEKCGRNHGYKGLDNSSFCPDSQCCVVGGPDCINSIIDMESVCKRVNASGLGVAVSVSRDAGRYLCDFTYYTSLYLSHGRSAFIHVPPLGKPYSKEDLGRALQAVIQEMLELMDQAEGKIHCQQHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CM19</accession>
    <name>A0A3P9CM19_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Cholinergic receptor nicotinic alpha 2 subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CM19"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023383"/>
    <dbReference type="Ensembl" id="ENSMZET00005024149.1">
        <property type="protein sequence ID" value="ENSMZEP00005023383.1"/>
        <property type="gene ID" value="ENSMZEG00005017497.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158299"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000014">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="22">
        <location>
            <begin position="16"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="23">
        <location>
            <begin position="229"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="488" mass="56487" checksum="D07575E0B87C135D" modified="2019-02-13" version="1">RTRLLLSEDWDRVHTEDELFRSLFRGYSKWTRPAKNVTDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWTDYKLRWSPSDFNNVTSIRVPSELIWVPDIVLYNNADGEFAVTHMTKAQLFYTGRIRWVPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYDRAKIDLEPFENTVDLKGYWESGEWAIVNAVGTYNTKKYDCCHEIYPDITYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSSETHTMPRWVRRLFLSVVPRWLCMKRPHHGLRPASDKLLPLQTPDEINHWDFHGYSNMEHLERFGSPSCLSARSLGYTLLPQTRSTVSLEWDTPVECGSTQNQWDSSLSPAVISALEGVTYIAEHLRAEDADFSVKEDWKYVAMVVDRIFLWMFIIVCLLGTVGLFLPPWLSGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CN91</accession>
    <name>A0A3P9CN91_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THAP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CN91"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023509"/>
    <dbReference type="Ensembl" id="ENSMZET00005024282.1">
        <property type="protein sequence ID" value="ENSMZEP00005023509.1"/>
        <property type="gene ID" value="ENSMZEG00005017591.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175632"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001935">
        <property type="term" value="P:endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF7">
        <property type="entry name" value="SI:DKEY-228B2.6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="190" mass="21919" checksum="1B0CC35BBF21C8B5" modified="2019-02-13" version="1">LPTIHCCVPLCSASAKFNGILSFHAFPTHSDLRRQWLLNIRRDHFTITSHTRVCCRHFASDQLIETERRPELVPPDDQEEHSLTRDHDYCSVPEPSALDISASAAEDLSKDVETLRKEIQELRVQREFGLQRFAALASDVTHLPKPRGSHSGPAELMPLRRRALLTCSFLYFVSHFQSYRQAFQMQKLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQN8</accession>
    <name>A0A3P9CQN8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LYR motif containing 5a</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553956.1">
        <property type="nucleotide sequence ID" value="XM_004553899.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004553957.1">
        <property type="nucleotide sequence ID" value="XM_004553900.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQN8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024116"/>
    <dbReference type="Ensembl" id="ENSMZET00005024907.1">
        <property type="protein sequence ID" value="ENSMZEP00005024116.1"/>
        <property type="gene ID" value="ENSMZEG00005018039.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464233"/>
    <dbReference type="KEGG" id="mze:101464233"/>
    <dbReference type="CTD" id="553589"/>
    <dbReference type="GeneTree" id="ENSGT00390000001810"/>
    <dbReference type="OrthoDB" id="8390896at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="85" mass="10284" checksum="415F1A47FD30E156" modified="2019-02-13" version="1">MSNPLKTEVIRLYKNLLYLGREYPQGAAYFKQRLKSAFMKHKDVTDPEKIKQLVARGDHVIKELEALYFLRKYRAMKKRYYEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRY8</accession>
    <name>A0A3P9CRY8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6</fullName>
            <ecNumber evidence="26">2.3.2.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">BIR repeat-containing ubiquitin-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Baculoviral IAP repeat-containing protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Ubiquitin-conjugating BIR domain enzyme apollon</fullName>
        </alternativeName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the BIRC6 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.24" evidence="26"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025120"/>
    <dbReference type="Ensembl" id="ENSMZET00005025938.1">
        <property type="protein sequence ID" value="ENSMZEP00005025120.1"/>
        <property type="gene ID" value="ENSMZEG00005018738.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156126"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000014">
        <property type="entry name" value="Baculoviral IAP repeat-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000001">
        <property type="entry name" value="baculoviral IAP repeat-containing protein 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022103">
        <property type="entry name" value="BIRC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12356">
        <property type="entry name" value="BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="24" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="32" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="23" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-0967">Endosome</keyword>
    <keyword evidence="21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0789">Thiol protease inhibitor</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0853">WD repeat</keyword>
    <keyword evidence="19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UBC core" evidence="34">
        <location>
            <begin position="4541"/>
            <end position="4708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="429"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="743"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="828"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1015"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="3557"/>
            <end position="3586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="3644"/>
            <end position="3663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="3862"/>
            <end position="3882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="3897"/>
            <end position="3926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="4422"/>
            <end position="4442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="4783"/>
            <end position="4825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="32">
        <location>
            <begin position="1572"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="33">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="33">
        <location>
            <begin position="757"/>
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        </location>
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            <begin position="831"/>
            <end position="840"/>
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            <begin position="841"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022753"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50127"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="4825" mass="525151" checksum="D794217EEEE1E258" modified="2019-02-13" version="1">[encoded data, 4825 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CS48</accession>
    <name>A0A3P9CS48_9CICH</name>
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        <submittedName>
            <fullName evidence="13">Secretin receptor</fullName>
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    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    <dbReference type="PANTHER" id="PTHR45620:SF13">
        <property type="entry name" value="SECRETIN RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="81"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="365" mass="42511" checksum="CA03A6C6EE4206E7" modified="2019-02-13" version="1">DATNAGWWDHVNCWPHAAVGDVVSQPCPGFLHTTGQVFRNCTELGWTDPYPPHDIACEYGFNESLPLEVHSSQRYFLFVRIMYSVGYSVSLVFLITAVAILSLLRRLHCTRNFIHVQLFLSFIFRAVLIFIRDAVLFSNEDSFHCHIYTVSCKFATVLSNYCIMANYSWLLAEGYYLYKLVSASLFSQRKHLSWYIILGWGSPVIIMSGWSFAKYLHEDEGCWEMRRSEWIWWILRLPVLLFIIVNLLFFLCILKILVAKLRTQDMPGNEFNHYRKLAKSSFLLVSLFGLHYILFAFLPHKVRANFSPVQNEIQRRWRRWKMKHRVQLEHRRKCGSMSQSGGSERGPTNITLLFKSASTPESGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSY6</accession>
    <name>A0A3P9CSY6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Angiopoietin like 5</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
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                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
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                <person name="Harris R.M."/>
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                <person name="Hourlier T."/>
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                <person name="Jaffe D.B."/>
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                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
    <sequence length="361" mass="40483" checksum="0FC1821AF3D22016" modified="2019-02-13" version="1">MRFLPHCSSTDQWSTHCYVLCLFLLINCFGAASPLYAPPAPTGLLSAFSATQTSSVVGGKQKAVTFNRLVVNIGRDFNPDTGHFRCRIPGAYYFSFSVGKFPKKMLSVILVKNGEEVQAIAYDDFRKKGRKVQSQSLMIGLKKMDIVWLRLQPSPQYALYSNAGPYITFSGYLVYPDAMATSYISNHLSTPALPYPNCPPQVRGQREQPRSAFSVARTSTLMGHSSWTQEKPPITFDVEYVNIGGHFNKTSGRFTCHFPGVYFFAFTVGKHPRRAVSVKLMTGKGEVQAMVFDDDTSKRREMQSQSLLLSLSRGDSVWLYSQQDERFAVYSNQGRYTTFSGFMVYPDTETPATSQEDRGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUT6</accession>
    <name>A0A3P9CUT6_9CICH</name>
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        <recommendedName>
            <fullName evidence="6 15">E3 ubiquitin-protein ligase listerin</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 15"/>
    <dbReference type="RefSeq" id="XP_004550073.1">
        <property type="nucleotide sequence ID" value="XM_004550016.3"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005025829"/>
    <dbReference type="Ensembl" id="ENSMZET00005026663.1">
        <property type="protein sequence ID" value="ENSMZEP00005025829.1"/>
        <property type="gene ID" value="ENSMZEG00005019271.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471659"/>
    <dbReference type="KEGG" id="mze:101471659"/>
    <dbReference type="CTD" id="26046"/>
    <dbReference type="GeneTree" id="ENSGT00390000016055"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001251">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056241">
        <property type="entry name" value="LTN1_HEAT_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24618">
        <property type="entry name" value="LTN1_E3_ligase_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1717"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1768" mass="197652" checksum="D47D1101AFD851AE" modified="2019-02-13" version="1">MGGKNKQRTKGNVRPSSSGRAAEVLTREGGVIPAFVGFGSTVASELSYVPAVHGAEDIDNLVDADFRLVLRKLSKRDVVTRLKAVQDFGSMCQERDADVVKGILPYWPRIYCKISVDHDRRIREATQQAFEQLVLKVRRSLAPFLKSLMGHWILSQCDTHTPAASAAFQAFQAAFSPAKQPEAISFCKDEILNVLQDVLLKETADTLSDSQSLTEEEREAKYVRMLTSSLLGVKRLLSLLLQDDRAALETGLAHLVNSGKFWKYGKHKIPQVRGAFFEMVCALCEFTPGLVHAEAARLCPAVLLSIDDTDPVVLPPVWEAVLHVVSTIHDCWTHVNAKKGFLPKLWALLKEGGKGMAKALHPNLMPLLSKLPPEVTDPKMDFFTMFFTTFAQGLSSERAVTSPSESAAIVTSFVECLRYCVLQNAEDVDDQGKIRSMLNSQQLLPLLENALRNPSLQNGPLFLSVTEMLISWEKRVGLQREGEASDSKDVFQRLLTDFWEELGLLCVSYVDNEEADPQALEGIATLLHVMRYPERVNKKQTQKKKSVRLCFSKPEENEKTGVEGDGAEKLAQAVSELVNEKAFGSLQTQHFEDVVCQLAQLCLVHVNEKNSERHLVFLSHLMRSFHTPRVFSTLAELDDKMTKDEKQRDEGIMKNPAVQFLLERVVVWLAEKGRTDTEHLVEMVFSSLHCCSGQETNRILNHITTMGLSWGIILQIIQRACTDPETLKSCSDWLKGSVLGEQLLGLTEELCKVGSSSCDSISSTSGHSWTLISLVLSQHHNNESLIGEVYMEKILEKLHATLSETKSLSDKGNMEPLISFICDVASTFFSSVQDCLLLVSAEELLLTVFQLTAQDQAHTHLSDSLLHKMRKVCVAGVQSLVQHCEYEVKEGGFLHSAAVWVRKQLLATPLDMKGIQVLVLAVQSVVESIISVCDQASSIIIQFFTLLMPSQTEWTRIRRALPPQWIKSPLLSSRLRDVCEKPSMDMWKFRELNKLPAHLCACALLGKVAHSAAFTHGGQSEAESPSLQQNLTYTVSELLYALQWCKELNYSPTMVSTYHNMLTDWGLSEGLNGQVPMKPLQETLYTRSVTEGGLWSLTLENYIHSNSLEGAAVRKLYGSANSLFPVSQSKLNTLQVLCPSMSNEDRESLVALATAGLVNWQEDENVYGCLAVLLCCLNASTQVEDKVVQAILATVMEWRNSREDWFLFSCDLSKATSEQLNLSVEIMRFLSWLVTRCPAILGGSQWDFLLCSMLAWLETASENVGSLWNPWVQLFVCENAGLIVKLNEFFTTLSSSNIADKLPPELAGEWTDFFVEGIYNLLLPLPVSITEAFAEPDDPVFPLAVLQSVGVALTHVPVQQLTQNSLPPRFIADQKTNLPEPLQTLLNTFCPLLLFKARPLQIAVYHILEKVMPQLPECDGEGDNNKSDDDRDEPCLSPPASLMAILSTCEELCDNILSGIQVGEFAVVQPLSVEYSCILGYLLSWKLLLTFFKSSSSHLRANYAQYLKRSCSLNKLLLHVFKLMPENPAYPGQEAEARETKTFFTESLNLAVDKCDSVEWELPHLACSVYYSTVQDLPAMVRLWWNSQEKRVSAAVEKFTIKYISPVLSAQEISSVHTSTQMFDSMTVKARSAAREVIATYSVDDIFIELVIQLPQNYPLGSIAVESGRRVGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGIEDCMICFSVIHGSNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CV00</accession>
    <name>A0A3P9CV00_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AVL9 homolog (S. cerevisiase)</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551851.1">
        <property type="nucleotide sequence ID" value="XM_004551794.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CV00"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026205"/>
    <dbReference type="Ensembl" id="ENSMZET00005027050.1">
        <property type="protein sequence ID" value="ENSMZEP00005026205.1"/>
        <property type="gene ID" value="ENSMZEG00005019540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473521"/>
    <dbReference type="KEGG" id="mze:101473521"/>
    <dbReference type="CTD" id="23080"/>
    <dbReference type="GeneTree" id="ENSGT00390000010255"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="14"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="629" mass="69198" checksum="845B980CBE99526C" modified="2019-02-13" version="1">MEPQGRDEGKGPVLHIVVVGFHHKKGCQVEFSYPPLMPDEGHDSNLLPEEWKYLPFLALPDGAHNYQEDTVYFHLPPLSGDTKCVYGVSCYRQIEAKALKVRQADVTRETVQKSVCVLSRVPLYGLLQAKLQLITHAYFEEKDFSQISILKELYDHMNSSLRGSALDGSQVYLGMSPRDLILHFRHKALIIFKLILLEKKVLFYVSPVNRLVGALMTVLSLFPGMIEHGLVDSSHYRPKSSVSEDQSLVESVSGAEEFVSVSVTDIDSSALDLGVETAQPATESSGNSSEGDNHHLKPPSRISPESSESEWETLDPSVLDEGGPQEAPSETEPELPETFDSKPGTPITVQPQAVTGQGGVTQGLVSGLEEDQYGLPLAIFTKGYLCLPYMALQQHHLLSDVTVRGFVAGATNILFRQQRHLSDAIVEVEEARIQIQDPELRKMLSLTTADLRFADYLVKHVTENRDDVFLDGTGWEGGDEWIRAQFTLYLHSLLSSALQQDSERLLADYGAPFVTAWKITHNYRVWYSNKHPGMTAVTPGHPFQGQYSVADVKLRLSHSVQNSERGKKIGNAMMTTSRSVVQTGKAVGQSVGGALTSAKTAMSTWFSTLAQPAPASTPACPEPATAVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVY9</accession>
    <name>A0A3P9CVY9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI domain-containing protein 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014268852.2">
        <property type="nucleotide sequence ID" value="XM_014413366.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014268854.2">
        <property type="nucleotide sequence ID" value="XM_014413368.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVY9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026498"/>
    <dbReference type="Ensembl" id="ENSMZET00005027355.1">
        <property type="protein sequence ID" value="ENSMZEP00005026498.1"/>
        <property type="gene ID" value="ENSMZEG00005019768.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473017"/>
    <dbReference type="KEGG" id="mze:101473017"/>
    <dbReference type="GeneTree" id="ENSGT00950000182810"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="210" mass="24060" checksum="420A222478975637" modified="2019-02-13" version="1">MVKYFCSSTDIRSTWDHVVSAFWQRYPNPFSTHVLTEDVVYREVTADHRLLSRRLLMKTNRLPRWAERLFPAGMSRSVYIIEDSIVDPVNKSLTTYTWNLNHTTLMSVEERCVFQGSVEHPATTQLKREAWISSSIYGFSKPIQEFGLARFKSNQVKAMKGLEYALSNLQGEAPQRLLRDTVKDASEKAKEAAKTLASAAAVPQKPRQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CX89</accession>
    <name>A0A3P9CX89_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT LRR and PYD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CX89"/>
    <dbReference type="Ensembl" id="ENSMZET00005027823.1">
        <property type="protein sequence ID" value="ENSMZEP00005026958.1"/>
        <property type="gene ID" value="ENSMZEG00005020111.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287022"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9032" checksum="77CF976CF4A2AFAB" modified="2019-02-13" version="1">MNLCSFFRLDSCSLSEISCAALASALKSNPSHLKELDLTDNKLKDADMRQLCDLVEKPNCGLKTLRSVDGLSVPMLLYIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CY60</accession>
    <name>A0A3P9CY60_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554159.1">
        <property type="nucleotide sequence ID" value="XM_004554102.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004554161.1">
        <property type="nucleotide sequence ID" value="XM_004554104.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CY60"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027273"/>
    <dbReference type="Ensembl" id="ENSMZET00005028145.1">
        <property type="protein sequence ID" value="ENSMZEP00005027273.1"/>
        <property type="gene ID" value="ENSMZEG00005020344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469661"/>
    <dbReference type="KEGG" id="mze:101469661"/>
    <dbReference type="CTD" id="11079"/>
    <dbReference type="GeneTree" id="ENSGT00510000047137"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="195" mass="22673" checksum="6500EDCCA3C1CE4A" modified="2019-02-13" version="1">MSEGDSAGESIHGKTSVVAAFFTRVGQVYQSWLDKSTPFYAMRWAGTLLLTLVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLLEEDEGPSLPTKQNEEFRPFIRRLPEFKFWHSATKGIVIAMICTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMVKYRYLPFTHGKRTYKGKEDTGKAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZ11</accession>
    <name>A0A3P9CZ11_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Cholinergic receptor, nicotinic, delta (muscle)</fullName>
        </submittedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014268561.2">
        <property type="nucleotide sequence ID" value="XM_014413075.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZ11"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027605"/>
    <dbReference type="Ensembl" id="ENSMZET00005028483.1">
        <property type="protein sequence ID" value="ENSMZEP00005027605.1"/>
        <property type="gene ID" value="ENSMZEG00005020586.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474111"/>
    <dbReference type="KEGG" id="mze:101474111"/>
    <dbReference type="CTD" id="1144"/>
    <dbReference type="GeneTree" id="ENSGT00940000159794"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000010">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000012">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 19" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022261086" evidence="19">
        <location>
            <begin position="24"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="27"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="256"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02931"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02932"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027605.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="522" mass="60375" checksum="AE4C1968C7698CB4" modified="2019-02-13" version="1">MELQRAALATLFLLTLLSSECNGRNEEERVIEYVFKEMGYNKELRPVEKQQDVVDVNLALTLSNLISLKEVDETLLTNVWLEITWTDYRLTWNSTEFGGIEILRLPPSMVWLPEIVLENNNDAQFEVAYYSNVLVYENGFCYWLPPAIFRSSCSINVRYFPFDWQNCTLKFTSLTYNAKEIRMLLKEEYAGEVANYTVEWVVIDPASFTENGEWEIVHRPAKRNIYKHIPMDSNKHQDITFYLIIKRKPLFYIVNIIIPCVLISFLACLVYYLPADSGEKMTLSISVLLAQSVFLLLISQRLPETSMSVPLIVKYLMFIMVLVTVVVLNCVVVLNLHFRTPSTHVMTEWTKRFFLERLPRLLLMSHPAEAEPAWDGALPRRSSSVGYIAKADEYYTVKSRSELMFEKQSERHGFTTRVTHAALVKPQDDGGVTDQLYSEMKPAVDGANYIIKHMRNKNEYNEEKDNWSGIARTVDRLCLFLITPVMIFGTIIIFLMGACNSPPRLPFEGDPHDYMENHARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2T1</accession>
    <name>A0A3P9D2T1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plac8 onzin related protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562802.1">
        <property type="nucleotide sequence ID" value="XM_004562745.2"/>
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    <dbReference type="Ensembl" id="ENSMZET00005029836.1">
        <property type="protein sequence ID" value="ENSMZEP00005028920.1"/>
        <property type="gene ID" value="ENSMZEG00005021578.1"/>
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    <dbReference type="KEGG" id="mze:101474157"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
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    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="132" mass="14994" checksum="F7C1FBB3C4102723" modified="2019-02-13" version="1">MAFQHSTTQVVVTTTAMSQQSGQWSTGICDCCSDMNSCCFGYWCFPCMQCDTASKHGWCCAMPLLDFCCVVSCLLRNSVRERYNIPGSCCDDCCKIFWCYHCVWCQMHRELKIRENQYPAASTVVTTQVIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2U6</accession>
    <name>A0A3P9D2U6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Endoplasmic reticulum oxidoreductase 1 beta</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D2U6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028903"/>
    <dbReference type="Ensembl" id="ENSMZET00005029816.1">
        <property type="protein sequence ID" value="ENSMZEP00005028903.1"/>
        <property type="gene ID" value="ENSMZEG00005021555.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007753"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF2">
        <property type="entry name" value="ERO1-LIKE PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017963847" evidence="17">
        <location>
            <begin position="23"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="16">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="437" mass="50844" checksum="C0B0ED0F26D3CC04" modified="2019-02-13" version="1">MEEHHHLILICPALLQLTGVLDDCFCDVESIDIFNNLKIYPRIRKLTERDYFRYYRVNLKRPCPFWPDDGHCSIKDCHVEPCPEVSHVIKNPSCVQYSQAANTMSDVVECQQAKELGAINSTLSNQSKEAFADWARHDDAQDHFCELDDETSPDAEYVDLLLNPERYTGYKGPSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDQREGFYTWLEGLCLEKRVFYRLISGLHSSINIHLCAEYLLDEGWGRSVWGPNVQEFRQRFDMAETKGEGTRRLKNLYFLYLIELRALYKVAPYFERAIVNLYTGNAQEDGETKDLLLHIFNEIKAFPMHFDEKSMFAGHKLEAKTLKCIRLHAPRHVSVICRLGPQTEGLGTALKILFSEKEIKNLPEHSPSKGFQLTRQEIVALMNGFGRLSTSIYQLHHFRQLWKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3P5</accession>
    <name>A0A3P9D3P5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3P5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029198"/>
    <dbReference type="Ensembl" id="ENSMZET00005030116.1">
        <property type="protein sequence ID" value="ENSMZEP00005029198.1"/>
        <property type="gene ID" value="ENSMZEG00005021769.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005213"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="126" mass="13703" checksum="DD6C0D861C4EBAC2" modified="2019-02-13" version="1">MKRHVAKTSTASLGRFQDRLPKENPAKKGKKRKFEPLIGNFSNEKQKQLELLKVMDTKKPKLDITKAVNKQMRQEDREEAAAKHKKAAGKKGRKGGSMGGKARGKGGKGKAAGGGGGKRRGKPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3Q1</accession>
    <name>A0A3P9D3Q1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3Q1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028716"/>
    <dbReference type="Ensembl" id="ENSMZET00005029624.1">
        <property type="protein sequence ID" value="ENSMZEP00005028716.1"/>
        <property type="gene ID" value="ENSMZEG00005021414.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163251"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="106"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="524" mass="58918" checksum="DD3EA219C0C1E9DC" modified="2019-02-13" version="1">MRDYEGSIAFLGIWGWYQVKVIFFLCTLSFPAGYNILSVIFLLAIPPHQCYIPAHSNLSQDWIQASIPIQVRTSGRSSCSRYEMHMMQNLSALGIKPNLAQIHNDSEFGASAGVMLSNLKQEECKDGWIYSTEHYKLTVVTEFNLVCDNKWKQPMSSLIYFLGSLCGCFLSGQISDRFGRKPVLFSSIFILSVFNIALSFAQSWAVFNVLFFMVGMGQVSICIVLLVLGSELLVDVPRVLFSSLALSFFYSAGMVAFPGTAYIVRNWRYLSVLMALPGLACFPLWWLVPESSRWLVSKGRFKEAELLLRFAALENGVEFPSDLFRSAKVRASDLILVQRVSGYLGLLRNTTTRSITLVVWFLWFSLNVSYFGLSFNMTTLYGNPFLNYALLSLMDIPAHLVSWFSAKYFPRRVSFIVFSLLGALLKVLLLPSEYHNITLTLVLIGKFGVLASEGILHLLTGELSPTVIRNTMLSSAALFSRVGSSITPYILQLAVFYEFLPWLTVTSFGKTLPDTIDQMQVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D498</accession>
    <name>A0A3P9D498_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D498"/>
    <dbReference type="Ensembl" id="ENSMZET00005030092.1">
        <property type="protein sequence ID" value="ENSMZEP00005029174.1"/>
        <property type="gene ID" value="ENSMZEG00005021746.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177152"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029383">
        <property type="entry name" value="ARL6IP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28640">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28640:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15062">
        <property type="entry name" value="ARL6IP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="103" mass="11639" checksum="A83985D301A84526" modified="2019-02-13" version="1">LDIMSLPSAAWFLCALIYPILKELRAERVTGEDGTEEKMLGFWSLLVLSVLVGCICCVFSWMLTYLDSFQPGMDFPTLYHMGKSPVVIHQSCSNKPKVQEHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D5M6</accession>
    <name>A0A3P9D5M6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cilia and flagella associated protein 61</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D5M6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029975"/>
    <dbReference type="Ensembl" id="ENSMZET00005030918.1">
        <property type="protein sequence ID" value="ENSMZEP00005029975.1"/>
        <property type="gene ID" value="ENSMZEG00005022350.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004987"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038884">
        <property type="entry name" value="CFAP61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056299">
        <property type="entry name" value="CFAP61_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032151">
        <property type="entry name" value="CFAP61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21178:SF8">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23150">
        <property type="entry name" value="CFAP61_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16092">
        <property type="entry name" value="CFAP61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cilia- and flagella-associated protein 61 N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="466"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP61 dimerisation" evidence="4">
        <location>
            <begin position="831"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115716" checksum="CD3BFFCEE4D34734" modified="2019-02-13" version="1">MQTVTSDSAREETVTVRRSESADAEEIDGLISPSAQAVFGRVNVIHLLEKANLAVTLTNEKGDILGHASFFDHPIGDLVDQTQWEAFMQEHFSVGQCTPFNTLFLHLFVARPNFTTASVKEIMRYDKKKSVSIFPFFRVEDHNDIIPLFDEQTNLLSISHQPFFLAALIEAEEHHTAVCEMNTVVLYSLKSVCVCCHTSQQEEAEISEKSNTFCIQIFDQNFCVITVPNLSTEFPLLQNFIRVPSIPTSLPQHELYIFHRDGIRSLSVRPAVALDRSAVSALVKDLSLNESLLQDLDRYYETGCDQVSQQTLLLTHLQSDSQRLCDIEYIRAHYNIESFIYFSHHGYDEHAQILHFVLKTTVQHFSKNFFKEVLRQARKSCLYLRIYPPYHTGRENKLLKNSCVHHLHYVLNCAVPVCPRRQIIYPLEELGINAPSRRLTEDQAPFALSLVSRKLTMEPKVTINTRIVLVGASDTGLAFLEVLCSCPHLRFNSLTLISTHGFPGDYNREDAGFLSTSHAYSSRDLAQIPVRSFIRVVTGKLVGIRRKSKYVLLSSGEKVPYDHLILCTGLQYRVPCPTGVDVSQPVTNSQLHSTHSRYTGPVPSNLFTLNDLHDCMAARRWLCANFLELEDNAIVYGNNIDIYTTVETLLSLGIRGSRIHLVLLPPVPGVSSFLDSSVEKAAAMAMENAMVQIHRNCVLAQFNNGKQPDPLTSASFTTDAEPLHLQCGVFINLSNKGVDYDAFNSFNKSFLVFDGRLVINSSFRTTNSSIWAAGPLTKFSRRYYIDEWTHANFNSKEVGQDLAAMMLPLFDPTVEPAEAPPPETDRLVLLYKQAKIQGGKLPGGYHYLHVTKPSPTDLTGPKLQDRAIVTGQPERGDYFCLHLDCYELVETLTCLSLKPLPVSNYLSLYMKHQQLLGQLLSCYQQGLIPDLYSFFTQSSCLAVFHDRFSDLEQELQQTLKLKVGAPLLISYITLIAEILLSTCVSLQDLCPPDQLKDEDSRAALRSSAVKYLSYNRNLLPMFACPGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D601</accession>
    <name>A0A3P9D601_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Natriuretic peptide A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the natriuretic peptide family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D601"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029587"/>
    <dbReference type="Ensembl" id="ENSMZET00005030521.1">
        <property type="protein sequence ID" value="ENSMZEP00005029587.1"/>
        <property type="gene ID" value="ENSMZEG00005022067.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000169392"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051427">
        <property type="term" value="F:hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006182">
        <property type="term" value="P:cGMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000663">
        <property type="entry name" value="Natr_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030480">
        <property type="entry name" value="Natr_peptide_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050787">
        <property type="entry name" value="Natriuretic_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002408">
        <property type="entry name" value="Natriuretic_peptide_brain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14066">
        <property type="entry name" value="ATRIAL NATRIURETIC FACTOR PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14066:SF10">
        <property type="entry name" value="NATRIURETIC PEPTIDES B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00212">
        <property type="entry name" value="ANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00712">
        <property type="entry name" value="BNATPEPTIDE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00710">
        <property type="entry name" value="NATPEPTIDES"/>
    </dbReference>
    <dbReference type="SMART" id="SM00183">
        <property type="entry name" value="NAT_PEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00263">
        <property type="entry name" value="NATRIURETIC_PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0838">Vasoactive</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017967244" description="Natriuretic peptide A" evidence="9">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15525" checksum="2E41B00BFC0DBF56" modified="2019-02-13" version="1">MRTEVLWGVLALLCQQTLVSSHILGRPSSANDLAQLKSLLERFEETLDEVVQKEDLEAYYEDMNQEPKSSQASQGWDQEGNQEPLISEKAQPLTEGKTVNQRSRLQDLLMATRKRTSGCFGARIDRIGNASGLGCNSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6D2</accession>
    <name>A0A3P9D6D2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease, RNase K a</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase K family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574384.1">
        <property type="nucleotide sequence ID" value="XM_004574327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6D2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029899"/>
    <dbReference type="Ensembl" id="ENSMZET00005030840.1">
        <property type="protein sequence ID" value="ENSMZEP00005029899.1"/>
        <property type="gene ID" value="ENSMZEG00005022305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480293"/>
    <dbReference type="KEGG" id="mze:101480293"/>
    <dbReference type="CTD" id="751692"/>
    <dbReference type="GeneTree" id="ENSGT00390000009664"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="100" mass="11119" checksum="A922AD3FCA041D3F" modified="2019-02-13" version="1">MRGLICGPKLAACGIVLSMWGVVMLALLGIFFTTNSAVLIEDVPLTDEDTFKDLDPPHRAYDVYQKVGYNCFIAAAMYVVCGLFSCCQMKLNKKKEYLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D942</accession>
    <name>A0A3P9D942_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="15">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54256"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:13840"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:138021"/>
            <dbReference type="EC" id="1.14.11.79"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-histidyl-[ribosomal protein uL15] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54024"/>
            <dbReference type="Rhea" id="RHEA-COMP:13760"/>
            <dbReference type="Rhea" id="RHEA-COMP:13761"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:138021"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="15">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ROX family. MINA53 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="15"/>
    <dbReference type="RefSeq" id="XP_004574342.1">
        <property type="nucleotide sequence ID" value="XM_004574285.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004574343.1">
        <property type="nucleotide sequence ID" value="XM_004574286.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004574344.1">
        <property type="nucleotide sequence ID" value="XM_004574287.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D942"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030869"/>
    <dbReference type="Ensembl" id="ENSMZET00005031849.1">
        <property type="protein sequence ID" value="ENSMZEP00005030869.1"/>
        <property type="gene ID" value="ENSMZEG00005022994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469377"/>
    <dbReference type="KEGG" id="mze:101469377"/>
    <dbReference type="CTD" id="84864"/>
    <dbReference type="GeneTree" id="ENSGT00390000000083"/>
    <dbReference type="OrthoDB" id="425950at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032453">
        <property type="term" value="F:histone H3K4 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036139">
        <property type="term" value="F:peptidyl-histidine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1500">
        <property type="entry name" value="JmjC domain-containing ribosomal oxygenase (ROX), dimer domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="NO66-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046799">
        <property type="entry name" value="ROXA-like_wH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="MINA53 MYC INDUCED NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096:SF7">
        <property type="entry name" value="RIBOSOMAL OXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20514">
        <property type="entry name" value="WHD_ROXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="141"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="470" mass="53345" checksum="E2B49D8E51B101AD" modified="2019-02-13" version="1">MPKKSKTPSVKRRIADQEQPAVKRSKEEQSDTSPLCFQSPATLFESLIQPMGTDRFFSEYWEKKPLHLQRSDPGTASYYQSLFQLCDLQSLCSQGLEYYRDINVVRCVNGKKKLLNKEGRVKHSVLNKIMSQNKATVQYHQPQRFKDELWRIQEKLECFFGALVGSNIYITPEESQGLPPHYDDVEVFILQLQGQKHWRLYNPTVPLAAEYSVQSEDSIGIPTHDIILKAGDLLYFPRGTIHQARTPAGVNCSIHLTLSTYQRMSWGDLLLDVFPSLLCGRSRREVSLREGMARRLLLSSSAGLHTNQRLAASLRALADEMETGAQDLGFTHMKRDFIMNRLPPYCQQQLSSPSGKSPALEDTVILTFKDHVVITVEPRPQSTDDATELVVFVLHSLKNQREGHMMGDSCDDQEERSISTGLQFPLSYLQALGQLQLAEQLVVAQLQLPTQEDKLNLALALWSENLLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DBI8</accession>
    <name>A0A3P9DBI8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arfaptin-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004573988.1">
        <property type="nucleotide sequence ID" value="XM_004573931.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DBI8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031898"/>
    <dbReference type="Ensembl" id="ENSMZET00005032932.1">
        <property type="protein sequence ID" value="ENSMZEP00005031898.1"/>
        <property type="gene ID" value="ENSMZEG00005023797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465544"/>
    <dbReference type="KEGG" id="mze:101465544"/>
    <dbReference type="GeneTree" id="ENSGT00950000183040"/>
    <dbReference type="OrthoDB" id="9994780at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07660">
        <property type="entry name" value="BAR_Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF4">
        <property type="entry name" value="ARFAPTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="3">
        <location>
            <begin position="110"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="330" mass="36975" checksum="8CACB6D70DB49B81" modified="2019-02-13" version="1">MAVVEQRGSVTVASAVTEEEIPPKEANGNGSHASNDVTAPTAETTPDVPEEQKQSKGFSLTPEIPQGVVIQGNNSNPASEKFRRVRNWSITKYKYTRQALSEKLGRGSRTVDLDLEPRLELLKDDRQRYENMTSLAQTLASQLSQLTVTQKNLGDAFTELSVKTPTLHLEFGINADAQRFLSKSGETLTEAINAFTSDMNTLVNKTIEDTMINAKQYETVRIEYDAFRVDLEELNMGPRDAVTVPKLEQAQKDFQTQREKYEKLRDDLSVKVKLLEGNKVKVLRNQLWMLHGAFAAHSLSCQNFLEKNIQEAGEHLNNVSTDVPSFLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DC37</accession>
    <name>A0A3P9DC37_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DC37"/>
    <dbReference type="Ensembl" id="ENSMZET00005033298.1">
        <property type="protein sequence ID" value="ENSMZEP00005032255.1"/>
        <property type="gene ID" value="ENSMZEG00005024029.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183052"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001155">
        <property type="entry name" value="Zinc finger 30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000149">
        <property type="entry name" value="Zinc finger protein 569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000290">
        <property type="entry name" value="Zinc finger protein 697 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="378" mass="43158" checksum="51EEB17781AB22B5" modified="2019-02-13" version="1">IKEEQEELCSSQEGEQLGLKQETEQKLSSEQLLSHSSPETESQEDKTGHDQRVDDTPASDSQSKTETKTNVLTCDNCGKMFNSESDLTTHRRVHTRKKSCKKSHPCSTCGKELVSKSALEAHIRTHTGEKPFSCSTCGKSFCRKSALKTHTRTHTGEKPYSCSTCNKTFGQNWTLQAHVRTHTGEKPYSCSTCNKTFTQNSTLRSHVRTHTGEKPYSCRTCGKRFSEKSNMEIHTRTHTGEKPYSCSTCNKTFTQNSTLHKRRHTGERPHSCNTCGKRFFQKSHLSDHVKIHSDEKPHLCRTCGKRFKLNSTLQRHVRIHTGEKPHLCRTCGKRFKLNSSLQRHVRIHTGEKPYSCSSCGKRYRRLDHVKIHMKIHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFB7</accession>
    <name>A0A3P9DFB7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Growth hormone secretagogue receptor type 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GH-releasing peptide receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ghrelin receptor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFB7"/>
    <dbReference type="Ensembl" id="ENSMZET00005034281.1">
        <property type="protein sequence ID" value="ENSMZEP00005033173.1"/>
        <property type="gene ID" value="ENSMZEG00005024115.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271823"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001616">
        <property type="term" value="F:growth hormone secretagogue receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003905">
        <property type="entry name" value="GHS-R/MTLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF7">
        <property type="entry name" value="GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01417">
        <property type="entry name" value="GHSRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="58"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="382" mass="42633" checksum="39EBE5AC6E45056D" modified="2019-02-13" version="1">MDVDGGRSCGEKNCGLTSGFPEDCSNQECHWEEPMFGLIELVCVTVIYIPLMLFGLLGNILTILVVWLRPHMRTSTYLYLSSMAVSDLLILLLLPLDLYKLWRPRPWPLGDLACKLTMFLSECCTFCTILHITFLSLERYLAVCWPITAKTVVTRRRTRAIIGCLWLSAAVSAAPVLVMVGVEDGGGLDGSSNEGRGGETDKRECRCTHFAISSGLLSAMMILSNLYFLVPLCILGVVYSLIGRTLWLRPKSSRRDQSHRNTVKMLGVIVLAFVLCWLPFHVGRTIFSLSLEKMSPYPLLLTHLYFNLVSSVLFYLSAAVNPLLYNLMSARYRHAVRSLIREHHSLIPAGLTAAGVSLLFLPGDSSRLIVLTQHKTIHNSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGC9</accession>
    <name>A0A3P9DGC9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein FAM111A</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGC9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033775"/>
    <dbReference type="Ensembl" id="ENSMZET00005034961.1">
        <property type="protein sequence ID" value="ENSMZEP00005033775.1"/>
        <property type="gene ID" value="ENSMZEG00005025254.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005182"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14389:SF3">
        <property type="entry name" value="PROTEIN FAM111A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14389">
        <property type="entry name" value="SI:CH1073-475A24.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="641" mass="72800" checksum="E160CA2E3BBC2BA9" modified="2019-02-13" version="1">MASRSEVPRDTEDEEPHLTHSFEWSYRKNIYTHTCNQAQTIEDCLKKSPKFKAAAEKQDGKELVIVRSGKAIASHFPCRVIKNERLTLKFVKAVEKPKKPVSVSGYPCKKRQSNKLVIFHVIARGGKNVVRILKNPDLRKDMQEITVYAYEGEKVKQALRRDGRFLNTMFKKNCVLFNISTEVETEMCSFVDDLDDETFKIKLLDKSDPPESQPGSLDDVYVLQSESQAVDSGGYEELSQQTNTVKSETDNTIGKKTDLCGNMAPGNQLSDSKKLQVNLSAWFNILVKGKKAQVPKLSRIQNIFRQEFGNSAKRCQDVKTMRKLMKLSHSVCQVRINGKPQGSGFLVFSRFVLTNAHVIKDFCNDNGRLHERVTVTFSYESLEQNDGLIDVEEVVGIEYIPEVSGTDWALLKLNADQTLPDGLLTHSGFICHSGGISIIGHPGESVKKIDVCLVVSQENRSQVAERHWKDNQDCVQLLKDSFFKNVADDVQQRKHLLTYESCLYFGSSGSPVFNEDGDVVAMHSGGYAYPGVMGQNQSVIEFGYPFSDIIEHIIIQMVKREKFDVLKEYLSCKCTRQQNFLVDVKKLVESRNLTRFKNVVNSSVAVDDESLKAFFEFFSRREQPEPMDINRVHRRLTADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHZ6</accession>
    <name>A0A3P9DHZ6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Neurotensin receptor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHZ6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034355"/>
    <dbReference type="Ensembl" id="ENSMZET00005035561.1">
        <property type="protein sequence ID" value="ENSMZEP00005034355.1"/>
        <property type="gene ID" value="ENSMZEG00005025679.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271823"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016492">
        <property type="term" value="F:G protein-coupled neurotensin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003984">
        <property type="entry name" value="NT_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF9">
        <property type="entry name" value="NEUROTENSIN RECEPTOR TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01479">
        <property type="entry name" value="NEUROTENSINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="71"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="371" mass="41597" checksum="3D081B1A99DD0E86" modified="2019-02-13" version="1">MDLNFTLSGSDLIGFGSLAQKLFANNSLPPFDNSTVGPTSNEEELEVNTNVYAKVIVTIIYLALFAIGSLGNSITIYTLITRKTLQNLQSTVHYHLASLAVSDLLILILSMPIELYNFIWFHYPWVFGDAVCRGYYFLRDSCSYATALNIASLSVERYMAICHPFKAKSIMSRSRTKKLISAMWLASFALATPMPFIMGQRMRNGEMICTTVVSPVTVKTVLQVNAFLSFVIPMVAISVLNGVIANQLLRMFREAEQDNRVCMIGANPTMLNFTVESNRAQSLRHGVLVLRKKYILCWVFLRMELMLVSHFRSWEMVVPRNFKVFTVDTGLSDMVRGSRVEGCLLKSTVISTVLRSTSRSTSCRYADSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK52</accession>
    <name>A0A3P9DK52_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DK52"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034536"/>
    <dbReference type="Ensembl" id="ENSMZET00005035748.1">
        <property type="protein sequence ID" value="ENSMZEP00005034536.1"/>
        <property type="gene ID" value="ENSMZEG00005025800.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155834"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000061">
        <property type="entry name" value="Putative cyclin-dependent kinase 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF128">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="113"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="466" mass="53573" checksum="2DD64BDCAB9E552B" modified="2019-02-13" version="1">NININKYIHNNSSCTNIVHENLKMGSDGESDQASGTSSDEVQSPTGVCLRNRVHRRISMEDLNKRLSLPADIRIPDGYLEKLQLSSPPFDQPLSRRSRRASLSEIGFGKLETYIKLDKLGEGTYATVFKGRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKIFLFQILRGLSYCHKRKVLHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFYEMAAGRPLFPGSTVEDELHLIFRLLGTPTEENWPGISSIEEFKSYSFPKYKPQPIINHAPRLDSEGIELLLSFLRYESKKRISADEAMKHSYFRQLGMRVHTLPESVSIFTLKEVQLQRDPGYRNSSYPESGRWRIQMFNQLGFFRSFNEEMKSWSQLHFQVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMS6</accession>
    <name>A0A3P9DMS6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tumor protein p53 inducible nuclear protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Nuclear body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMS6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035598"/>
    <dbReference type="Ensembl" id="ENSMZET00005036856.1">
        <property type="protein sequence ID" value="ENSMZEP00005035598.1"/>
        <property type="gene ID" value="ENSMZEG00005026594.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063829"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029431">
        <property type="entry name" value="TP53INP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671:SF2">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE NUCLEAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14839">
        <property type="entry name" value="DOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="282" mass="30239" checksum="6443C32D16E03B2A" modified="2019-02-13" version="1">MCSEESDCMMQVDDESGIPLIAQSFPENNLSNRQDARTRTECPAPVPHPPHKRRRTHKGRPQGAVALVDPVSCPSPSPSDMGATTPVTLPRRVRLSTPSSTPSMSPGSGSECGGSGCSSRAGSERGCMDESWFVTPPPCFTAEGATAEASPMEDLLIEHPSMSVYVSPSNLSMVSNSNLSAVAEESMVSLGGSVRAAEPASVPATHGTMPTRVSRGAAAQAGALAKVTQVARVQRSKARVERRHLGRNRIQRQNRTREQIPRHAAHSRNTFLHQPSKRNFCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMT1</accession>
    <name>A0A3P9DMT1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vasopressin V2 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">AVPR V2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Antidiuretic hormone receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Renal-type arginine vasopressin receptor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS. Interacts with TMEM147.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cell membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMT1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035744"/>
    <dbReference type="Ensembl" id="ENSMZET00005037007.1">
        <property type="protein sequence ID" value="ENSMZEP00005035744.1"/>
        <property type="gene ID" value="ENSMZEG00005026693.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244882"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045907">
        <property type="term" value="P:positive regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001992">
        <property type="term" value="P:regulation of systemic arterial blood pressure by vasopressin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000190">
        <property type="entry name" value="Vasopressin V2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001817">
        <property type="entry name" value="Vasoprsn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF20">
        <property type="entry name" value="VASOPRESSIN V2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00896">
        <property type="entry name" value="VASOPRESSINR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 18" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10 18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="54"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU046427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="375" mass="41423" checksum="F4CF0AF8448E3436" modified="2019-02-13" version="1">MSVSVITDTYTSIDRPAVSETPTGANATERERDALLAVAEVVVLAVIFVMALLGNGLVLVVLLRRRRHHNPLHQFMLNLCVADLVVALFQVLPQLVWDAKGRFPGPDFLCRLVKYLQVLGMFASSYIIVAMTVDRHYAICCPLQAHRSGATKRWNSFIVLAWVLSLLLSLPQVFIFSRSELAPGVYECWGNFAESWGLKAYVTWMTLAIFILPVLIITICQVEQREPEDKIVTGMFLSSSSAQLQAGVPPGPTTPSAACSPHPTKLPPVRGGEVTAAMSKTVRMTLVIVLVYSLCWAPFFSVQLWAAWDPDPPQNGVAFTLLMLLASLNSCTNPWIYSAFSSSVSPELRLLLHCRPHTRRRASETNDSTITHTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DN62</accession>
    <name>A0A3P9DN62_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bryoporin-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nematocyst</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004575476.2">
        <property type="nucleotide sequence ID" value="XM_004575419.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024656020.1">
        <property type="nucleotide sequence ID" value="XM_024800252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DN62"/>
    <dbReference type="Ensembl" id="ENSMZET00005036986.1">
        <property type="protein sequence ID" value="ENSMZEP00005035723.1"/>
        <property type="gene ID" value="ENSMZEG00005026685.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005036987.1">
        <property type="protein sequence ID" value="ENSMZEP00005035724.1"/>
        <property type="gene ID" value="ENSMZEG00005026685.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101481355"/>
    <dbReference type="KEGG" id="mze:112431588"/>
    <dbReference type="GeneTree" id="ENSGT00940000165500"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042151">
        <property type="term" value="C:nematocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051715">
        <property type="term" value="P:cytolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046931">
        <property type="term" value="P:pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050677">
        <property type="entry name" value="Actinoporin_PFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009104">
        <property type="entry name" value="Anemon_actinoporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40388:SF2">
        <property type="entry name" value="ACTINOPORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40388">
        <property type="entry name" value="BRYOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06369">
        <property type="entry name" value="Anemone_cytotox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0166">Nematocyst</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="4" id="KW-1053">Target membrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="161" mass="17555" checksum="839246A2A7810B33" modified="2019-02-13" version="1">MGARQSVIHITNKTEGYTLQNPSLHLVSGLCQIPLPTKLGPSECGSALFSKTGGTARGSVGVFTYDLYDTAADRADKKIAVLFSVPFDYGLYSNWCAVGVFDGETNSDSALYHKMYRTPERGFVRGKADGYDLTHTDFNVTIKSSMTNFSVATLKVEVHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNJ6</accession>
    <name>A0A3P9DNJ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNJ6"/>
    <dbReference type="Ensembl" id="ENSMZET00005036969.1">
        <property type="protein sequence ID" value="ENSMZEP00005035706.1"/>
        <property type="gene ID" value="ENSMZEG00005026654.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286922"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="82" mass="9243" checksum="E76FE648E8A25519" modified="2019-02-13" version="1">MAQKGVQLDRETFSCSICLDLLKDPVTTACGHSYCRNCIKSFWDEEDRKGIHSCPQCRKTFTTRPVLEKNTMLAALVEQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNR3</accession>
    <name>A0A3P9DNR3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MRG/MORF4L binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573291.1">
        <property type="nucleotide sequence ID" value="XM_004573234.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNR3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035923"/>
    <dbReference type="Ensembl" id="ENSMZET00005037189.1">
        <property type="protein sequence ID" value="ENSMZEP00005035923.1"/>
        <property type="gene ID" value="ENSMZEG00005026816.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478669"/>
    <dbReference type="KEGG" id="mze:101478669"/>
    <dbReference type="CTD" id="55257"/>
    <dbReference type="GeneTree" id="ENSGT00390000007823"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="220" mass="24034" checksum="CD143D99369B2840" modified="2019-02-13" version="1">MGEADVTLNQTDEKPPDSALAPGEDSVVWSHEVEVCLFHAMIGHKPVGVNRHFHMICIRDKFSQNIGRQVSSSVIWDHLGTMYDMQALHESEILPFPNNEKSFSLPDDIIQEVKEGKLGSEEESKEEFRMEREPPATHEEGSNSSVKMSERTSSIRDKERERDKEKGGSDGGLSSAATGGGGGSGSGGKEAEKRKRSRAAEKLLSSSNPASPGGAKRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNZ3</accession>
    <name>A0A3P9DNZ3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNZ3"/>
    <dbReference type="Ensembl" id="ENSMZET00005037213.1">
        <property type="protein sequence ID" value="ENSMZEP00005035947.1"/>
        <property type="gene ID" value="ENSMZEG00005026826.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244838"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF137">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="214" mass="24514" checksum="98EB1BC46373D0FC" modified="2019-02-13" version="1">MPAAEPAGCPGRARVMFDSSWSGSPAEPRSRLLPQPLNTQTKIPSEAGGKPQVSQSRVEVRISKIRVHTHVALDHICSYVNSLFLPLLYFCGSQVAGALWRYFISKGIEYLDTVFFILRKKFNQVTFLHVYHHCSMFTLWWIGIKWVAGGQSFFGAHMNAMIHVLMYLYYGLASCGPKIQKYLWWKKYLTIIQMHNSYSLFGAQIQFHVTIVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPA2</accession>
    <name>A0A3P9DPA2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15 20">Postsynaptic cell membrane</location>
            <topology evidence="15 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Presynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DPA2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036108"/>
    <dbReference type="Ensembl" id="ENSMZET00005037382.1">
        <property type="protein sequence ID" value="ENSMZEP00005036108.1"/>
        <property type="gene ID" value="ENSMZEG00005026945.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158852"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000072">
        <property type="entry name" value="glutamate receptor ionotropic, kainate 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 20" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
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        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="23">
        <location>
            <begin position="134"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="661"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
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        <location>
            <position position="360"/>
        </location>
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        <location>
            <begin position="442"/>
            <end position="496"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU367118"/>
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            <dbReference type="SMART" id="SM00918"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="687" mass="77215" checksum="E6A435C049A87E53" modified="2019-02-13" version="1">NTWTESCPSLSSALMFDAVHVVVSAVRELNRSQEIGVKPLSCTSPLIWQHGTSLMNYLRMVEYDGLTGHIEFNSKGQRTNYTLKILEKHPAGHKEIGIWYSNNTLAMNSTSLDLNASETLANKSLVVTTILENPYVMRKSNYQEYQGNDQYEGFCVDMLRELADILKFSFKIKLVDDGLYGAPEPNGSWTGMVGELINRKADLAVAGFTITSEREKVIDFSKPFMTLGISILYRVHLGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRERRDILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEAPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSKYAFLMESTMNEYYRSLNCNLTQIGGLLDTKGYGIGMPLGSPYRDEITLGILQLQESNRLEILKRRWWEGGQCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAIMEFVWSTRRTAETDEVSVCQEMLTEFRNAVSCKKNSRSRRRRPLTSTGGGVLRHPSRLTLAGPRPIRLIREMRLSNGKLYSGAGCPDLGPGPQRLLEDPLVAPPAPPRSFLQACSHVRICQECRRIQSLRPAALTPPPPGASPPPRPDPEADVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQX4</accession>
    <name>A0A3P9DQX4_9CICH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name type="scientific">Maylandia zebra</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSMZEG00005027458.1"/>
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    <sequence length="188" mass="18866" checksum="09E33A302F165AAD" modified="2019-02-13" version="1">MGVQVPTGSLLVTAYRGLEPGARLGHFGCGVPSASGSVTLAQLAAGGQLPGLTPSLLPGLQQLPGLTPSLLPRLKQLPGLTPSLLPGLKQLPGLTPSLLPGLKQLPGLTPSLLPGLQQLPGLTPSLLPGLQQLPGLTPSLLPGLKQLPGLTPSLLPGLQQLPGLTPSLLPGLKQLPGLTPSLGSSFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS67</accession>
    <name>A0A3P9DS67_9CICH</name>
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        <recommendedName>
            <fullName evidence="9">Leucine zipper putative tumor suppressor 2 homolog</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytoskeleton</location>
            <location evidence="9">Microtubule organizing center</location>
            <location evidence="9">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the LZTS2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS67"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037123"/>
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        <property type="protein sequence ID" value="ENSMZEP00005037123.1"/>
        <property type="gene ID" value="ENSMZEG00005027659.1"/>
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    <dbReference type="Ensembl" id="ENSMZET00005038420.1">
        <property type="protein sequence ID" value="ENSMZEP00005037124.1"/>
        <property type="gene ID" value="ENSMZEG00005027659.1"/>
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        <property type="component" value="LG13"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042074">
        <property type="term" value="P:cell migration involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060026">
        <property type="term" value="P:convergent extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051168">
        <property type="term" value="P:nuclear export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051255">
        <property type="term" value="P:spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03026">
        <property type="entry name" value="LZTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045329">
        <property type="entry name" value="LZTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028597">
        <property type="entry name" value="LZTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2 HOMOLOG-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19354:SF4">
        <property type="entry name" value="ZIPPER PUTATIVE TUMOR SUPPRESSOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06818">
        <property type="entry name" value="Fez1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="787" mass="85895" checksum="15D08C01C1A976C3" modified="2019-02-13" version="1">MALVQALPLTVSDHPNPGLDIQQCRPLSSHSPSGPCSGPCGHCTSDTAMGSVSSLISGRTYQERHCRAASEFNTKPRRSTPATSCFRLQDNTLRSGSSLEQLLVISNRTEPQAQVLPPPLPTKKQPRPGNSAGTGGGVTVAGTVGGVGGSTNGNFGYVSKEVVVGDWNDNLVLTAASPCSDSEDQKDNRTLNGNIGGPPPKLIPVSGQLEKNMEKVLIRPTAFKPVVPKNRHSVQYLSPRPGASTLSEASLNLLLPHGGSSSASGTSGNGGSSSSNSEGKCNSYTGGRNARSSQSCSMSDSGRNSLSSLPTHSSTGYSLAPSEGSSAGSGSGGQLEPVSGISRNTSGGGGSHGHSNSDSGRSSSSKSTGSGSLSGRGQPLSDSGSCGHSPPPVEGYEAVVRELEEKLRERDLELQQLRENLDENEAAICQVYEEKQRRCEREMEELRQSCATKMKQASQKAQRAQQVLQLQVFQLQQEKKKLQEDFSSLLQDRETLERRCATIQREQTQLGPRLEETKWEVCQKSGEISLLKQQLKEIQSELSQKAGDIVVLKAQLREARSELQASQIRSQEAQTALRTRSLELEVCENELQRRKSEAELLREKVSRLEEETARLRDALTGHSGPALPGNVAMKGQCMSLTLQQGRAVAGRGGPSPSVYRNGEETHLVWGGESDEAKAQRQNAETVLGLRQQVDRLKAELMYERRTGEEQLSRFDEERRVWQEEKEKVIHYQKQLQQNYIQMYRRNRDLERVMRELSLELENRDMEDYEVRSGSNDIHFEEITATEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DT71</accession>
    <name>A0A3P9DT71_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-hydroxymethyl-dCMP + H2O + H(+) = 5-hydroxymethyl-dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:77175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57962"/>
            <dbReference type="ChEBI" id="CHEBI:90409"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77176"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dCMP + H2O + H(+) = dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22925"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DT71"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037447"/>
    <dbReference type="Ensembl" id="ENSMZET00005038753.1">
        <property type="protein sequence ID" value="ENSMZEP00005037447.1"/>
        <property type="gene ID" value="ENSMZEG00005027923.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153676"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000021">
        <property type="entry name" value="Deoxycytidylate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="209" mass="22887" checksum="C77D2547680CCB84" modified="2019-02-13" version="1">MHHPGETKKTDFLVDTDYFMAVAVLSAQRSKDPNTQVGACLVNQDNKIVGTGHNCMPNDCEGKLPWNREGAKLDTKYIYVCHAELNAIVNASANADVKGCTMYVTLFPCNECAKLIIQAGLKEVVYLCDKYHARPETIASKKMLDRAGIPYSGWEVLSNIVFILDSIRLSDTTLRESSSIPTTLLALRISLLSLLASATLSLLPQHATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DU16</accession>
    <name>A0A3P9DU16_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glucosaminyl (N-acetyl) transferase family member 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DU16"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006604"/>
    <dbReference type="Ensembl" id="ENSMZET00005006902.1">
        <property type="protein sequence ID" value="ENSMZEP00005006604.1"/>
        <property type="gene ID" value="ENSMZEG00005005090.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005039068.1">
        <property type="protein sequence ID" value="ENSMZEP00005037748.1"/>
        <property type="gene ID" value="ENSMZEG00005028145.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160402"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF178">
        <property type="entry name" value="BETA-1,3-GALACTOSYL-O-GLYCOSYL-GLYCOPROTEIN BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="403" mass="46231" checksum="7F7B1FBA99685C77" modified="2019-02-13" version="1">MRQLEGTKCSFLVCLGISIIIFSFIYLRTRTPPELKPPPSSSCKPFSTVCKTFLPGMKKGVNWYSCDCQVSLAHHLPSFIVTIHKELELFVRLLRAIYMPQNVYCIHVDAKAPREYREAVQKLVSCFPNTFLSSHSETVTYAGFSRLQADLNCMKDLAKSKTDWKKVVNLCGQDFPVKSNLELVQYMQSQQWRDKNMTPGVKQPMSMMYRTQRQYKEIVGSHVAPKGLGLRKRPPPHNLQLYFGTAYYVLTRPFVDFVLKSPIAHDFLDWSRDTFSPDEHYWVTLNHIKEAPGSRIDGGWEGAIRAIKWRDQEGSAHSGCKGHYIRDICIYGVEDLPWIISMDSMFANKFESNTFPEALDCLEQWHRNKVINQATVPIEPSWLLAIHSNYSNSSSYFNSSAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DUE6</accession>
    <name>A0A3P9DUE6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DUE6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037887"/>
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        <property type="gene ID" value="ENSMZEG00005028302.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="121" mass="12552" checksum="FC33BDA9F23A739F" modified="2019-02-13" version="1">MLQIIILHKIEETLTCLLILQLMCYVELTLTFSQIYTNSALLGPSTTSALPGPSTNSALPGPSTNSALPGPSTTSALPGPSTTSALPGPSTNSALSPGAVNAKKLCQVRRCSTVKNLKNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K2CJ74</accession>
    <name>A0A0K2CJ74_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">COX3</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="16 17"/>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2015" name="Mitochondrial DNA" volume="1-2" first="0" last="0">
            <title>The complete mitochondrial genome of the Metriaclima zebra.</title>
            <authorList>
                <person name="Chen X."/>
                <person name="Song X.L."/>
                <person name="Chen L.Y."/>
                <person name="Li Y."/>
            </authorList>
            <dbReference type="PubMed" id="26273916"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Hoefler B.C."/>
                <person name="Straight P.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:11437"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KT221043">
        <property type="protein sequence ID" value="AKZ87024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KT166981">
        <property type="protein sequence ID" value="AKZ87037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009166320.1">
        <property type="nucleotide sequence ID" value="NC_027944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K2CJ74"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000008"/>
    <dbReference type="Ensembl" id="ENSMZET00005000024.1">
        <property type="protein sequence ID" value="ENSMZEP00005000008.1"/>
        <property type="gene ID" value="ENSMZEG00005000024.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:26037622"/>
    <dbReference type="GeneTree" id="ENSGT00390000013064"/>
    <dbReference type="OrthoDB" id="10050457at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01665">
        <property type="entry name" value="Cyt_c_Oxidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000048">
        <property type="entry name" value="Cytochrome c oxidase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.80:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="entry name" value="Cytochrome c oxidase, subunit III, four-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033945">
        <property type="entry name" value="Cyt_c_oxase_su3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403:SF7">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="Cytochrome c oxidase subunit III-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Heme-copper oxidase subunit III family profile" evidence="14">
        <location>
            <begin position="4"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AKZ87024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AKZ87037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="261" mass="29750" checksum="95B8D3924A169DD5" modified="2015-11-11" version="1">MAHQVHAYHMVDPSPWPLTGAVGALLLTSGLAIWMHFHNMTLLALGLILLLLTMYQWWRDIVREGTFQGHHTPPVQKGLRYGMILFITSEVFFFLGFFWAFYHSSLAPTPELGGCWPPTGITPLDPFEVPLLNTAVLLASGVTVTWAHHSIMEGHRKEAIQSLTLTILLGFYFTFLQAMEYYEAPFTIADGVYGSTFFVATGFHGLHVIIGSTFLAICLLRQVLYHFTSEHHFGFEAAAWYWHFVDVVWLFLYISIYWWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AR95</accession>
    <name>A0A3P9AR95_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 503</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Elbow/Noc family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561323.1">
        <property type="nucleotide sequence ID" value="XM_004561266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AR95"/>
    <dbReference type="Ensembl" id="ENSMZET00005000148.1">
        <property type="protein sequence ID" value="ENSMZEP00005000108.1"/>
        <property type="gene ID" value="ENSMZEG00005000157.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463964"/>
    <dbReference type="KEGG" id="mze:101463964"/>
    <dbReference type="GeneTree" id="ENSGT00390000014618"/>
    <dbReference type="OrthoDB" id="10054079at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048596">
        <property type="term" value="P:embryonic camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030902">
        <property type="term" value="P:hindbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000129">
        <property type="entry name" value="Zinc finger protein 503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051520">
        <property type="entry name" value="Elbow/Noc_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022129">
        <property type="entry name" value="Tscrpt_rep_NocA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522">
        <property type="entry name" value="ZINC-FINGER PROTEIN NOLZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12402">
        <property type="entry name" value="nlz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="564" mass="58048" checksum="E729CB392CFA286F" modified="2019-02-13" version="1">MITSPTVSVLRNSTNLAWESGSSGEKGAVKISQLSVHNSVSPADPTRQASRLPIKVLKMLTARAGHILHPEYLQPLPSTPVSPIELDAKKSPLALLAQTCSQIGKPDPPSSSKLSSVTSNGSSDKEAKSGPLKMSDIGADDKSSFKPYSKSSEKKDSSSSLSGDKNSFRVPSATCQPFTPRTGSPGSCTSVSPLPSEGKAGDKEEKKESDSNKSTMTESNGSHGISGITSDGNQQQENTSGSKAVTSDSISVTSSSSSVLGSGLVAPVSPYKPGHTVFPLPPAGISYPGSLAGAYAGYPQPFLPHGMTLDPTKSSSQLLSAQFAAASSLGCSKAGTSPLAGASPPSLMSASLCRDPYCLSYHCTSHLSGAASANCAHDSAAAAAAASALKSGYPLMYPTHPLHGVHSTTPSFSGHPLYPYGFMLPNDPLPHVCNWVSANGPCDKRFSSSEELLSHLRTHTAFAGTEKLISGYPGSSSLANAAAAAAMACHMHMPPNGSPSSPSTLALRGPHHPLGLSSRYHPYSKSPLPTPGAPVPVPAATGPYYSPYALYGQRLTTASALGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARJ5</accession>
    <name>A0A3P9ARJ5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARJ5"/>
    <dbReference type="Ensembl" id="ENSMZET00005000279.1">
        <property type="protein sequence ID" value="ENSMZEP00005000223.1"/>
        <property type="gene ID" value="ENSMZEG00005000236.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01080000257344"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001230">
        <property type="entry name" value="Immunoglobulin kappa variable 8-16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="123"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="241" mass="26408" checksum="0F45A1B2AE995F0D" modified="2019-02-13" version="1">MKLLYVFVSVSSESRGQITVTQPGAVSSAVGGTVNIKCRTSQNVNVWNNNHYLHWYQQKDGGVPKLLVYWSINRYSGIPARFTGSGSNSDFTLTISGVQAEDAAVYYCKREALVGHTHDCSLPLLQLLTRGRQHGQGGGDSTHSVSSAVGGSVSIKCRTSQNVYVSSNYHHLAWYQQKDGDVPKLLIRRAHERISGIPARFTGSGSNSDFTLTISGVQAEDAAVYYCQSFHYPNSQHVFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATK5</accession>
    <name>A0A3P9ATK5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="28">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="34 35">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="28">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="28"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATK5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000938"/>
    <dbReference type="Ensembl" id="ENSMZET00005001016.1">
        <property type="protein sequence ID" value="ENSMZEP00005000938.1"/>
        <property type="gene ID" value="ENSMZEG00005000780.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155181"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048403">
        <property type="term" value="F:brain-derived neurotrophic factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060175">
        <property type="term" value="F:brain-derived neurotrophic factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990416">
        <property type="term" value="P:cellular response to brain-derived neurotrophic factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099551">
        <property type="term" value="P:trans-synaptic signaling by neuropeptide, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000239">
        <property type="entry name" value="BDNF/NT-3 growth factors receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000034">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000033">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020777">
        <property type="entry name" value="NTRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020455">
        <property type="entry name" value="NTRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF575">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01939">
        <property type="entry name" value="NTKRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01941">
        <property type="entry name" value="NTKRECEPTOR2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 25 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="22" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11 25 27" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 28" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20 28" id="KW-0675">Receptor</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 31" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 28 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="18" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="31">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018161213" description="Tyrosine-protein kinase receptor" evidence="31">
        <location>
            <begin position="29"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="33">
        <location>
            <begin position="185"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="32">
        <location>
            <begin position="469"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="24">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="475"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25 27">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with SHC1" evidence="26">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with PLCG1" evidence="26">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="756" mass="85384" checksum="E5E84DD14A9AB4C3" modified="2019-02-13" version="1">MDSSAGEYGMARVGLFLVLMGLWRFSDACPASCTCSISRIVCIDSVPGIEDFPVLTLDDMENITEYIANQNRLFDLSDSSLRHYINLRNTVTKTRLTSISPDAFFNNTRLQYNLRDNNLSTLSWRTFQNFNITYLLSGNPLDCVCENLWIKLRLQEETDSPELTCTDDRGVAQDFATFRPPDCVPTVEVTPRNVTQMEGSNVKAICSASGSPAPEIVWNLDELWTHYELTLSGLSPDDNGRAIVCSAENMVGQTEASLQLNILAPTILTLLSPERDHHWCIPFTVTGNPKPELRWYHNNKPLQEQDYIRTMIHVTTENQQHGCLQLVNPTHIHNGEYKLVAENKYGRDEKNISAQFLHPPNINHTVYVVVGIAGVALIGCVLMMIILKYGRNSKFGIKSSSVISNDDDSASPLHHVSNGNNTPSSSEMGPDAVIIGMTKIPVIENPQYFRNSGSMLKSNTVQHIKRHNIVLKRELGEGAFGKVFLAECYNLTPDQEKIHVAVKFQTLKEASESGRADFYREAELLTNLQHEHIVTFYGVCVESDPLIMVFEYMKHGDLNKFLSHGPDAVLMADGQHSILVELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSSDYYRVGGHTMLPIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPYMRLNIKEIHSTLQSLAKASPVYLDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AW11</accession>
    <name>A0A3P9AW11_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Elongation of very long chain fatty acids protein 6</fullName>
            <ecNumber evidence="19">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">3-keto acyl-CoA synthase ELOVL6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">ELOVL fatty acid elongase 6</fullName>
            <shortName evidence="19">ELOVL FA elongase 6</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Very long chain 3-ketoacyl-CoA synthase 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Very long chain 3-oxoacyl-CoA synthase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ELOVL6</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:39675"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:61540"/>
            <dbReference type="ChEBI" id="CHEBI:76555"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:39676"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(9Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-eicosenoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:74011"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:36512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36503"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:74012"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:36504"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:36523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:74034"/>
            <dbReference type="ChEBI" id="CHEBI:74054"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:36524"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:60140"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:62543"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60141"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexadecanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctadecanoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:35315"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:71407"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:35316"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:39167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:39168"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="19">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Endoplasmic reticulum membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="19">N-Glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ELO family. ELOVL6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="19"/>
    <dbReference type="RefSeq" id="XP_004553671.1">
        <property type="nucleotide sequence ID" value="XM_004553614.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AW11"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001617"/>
    <dbReference type="Ensembl" id="ENSMZET00005001709.1">
        <property type="protein sequence ID" value="ENSMZEP00005001617.1"/>
        <property type="gene ID" value="ENSMZEG00005001323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486796"/>
    <dbReference type="KEGG" id="mze:101486796"/>
    <dbReference type="CTD" id="79071"/>
    <dbReference type="GeneTree" id="ENSGT01050000244965"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035338">
        <property type="term" value="P:long-chain fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03206">
        <property type="entry name" value="VLCF_elongase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033675">
        <property type="entry name" value="ELOVL6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF125">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 19 20" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 19 20" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 19 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 19 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19 20">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="269" mass="31598" checksum="9514A643DD45CC9C" modified="2019-02-13" version="1">MSVLALQEYEFERQFNEDEAIRWMQENWKKSFLFSALYAACILGGRHVMKQREKFELRKPLVLWSLTLAVFSIFGAIRTGSYMMYILMTKGLKQSVCDQSFYNGPVSKFWAYAFVLSKAPELGDTLFIVLRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYLVHAVMYSYYALRAAGFKLSRKFAMFITLTQITQMLMGCVVNYLVYSWMQQGQECPSHMQNIVWSSLMYLSYFVLFVQFFFEAYIGKSKSSAMAATKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AW85</accession>
    <name>A0A3P9AW85_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat and SOCS box protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AW85"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001956"/>
    <dbReference type="Ensembl" id="ENSMZET00005002054.1">
        <property type="protein sequence ID" value="ENSMZEP00005001956.1"/>
        <property type="gene ID" value="ENSMZEG00005001586.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165522"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000016">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF18">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="7">
        <location>
            <begin position="260"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="309" mass="33257" checksum="BB58802CCA327AA4" modified="2019-02-13" version="1">MLPAPCGATEVSRKRGAEPGLLPRHVSERKRACWGILTSQGSWADRSPLHEAASQGRLLALRTLLAQGYHANIVTIDHVTPLHEACLSGHVACVRALLNAGANVNAATIDGVTPLYNCCTSGSVGCVELLLQSGAHTRAHHTHFPSALHEACKRGNSHCVEALLSHGADPDYEVSHLGSPLYVSCLHRHTACSKVLLHRGADVSVGRGCDSPLHAAVRQDSADQVSLLLDYGANTNFRDGNNQRPVELAPPGGKTHQLLLAFEASPRSLCQLCRLQIRNLIGRSRLNLLPVLPLPGLLTHYLDYRSNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AY50</accession>
    <name>A0A3P9AY50_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004575161.1">
        <property type="nucleotide sequence ID" value="XM_004575104.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AY50"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002611"/>
    <dbReference type="Ensembl" id="ENSMZET00005002724.1">
        <property type="protein sequence ID" value="ENSMZEP00005002611.1"/>
        <property type="gene ID" value="ENSMZEG00005002070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464886"/>
    <dbReference type="CTD" id="100534737"/>
    <dbReference type="GeneTree" id="ENSGT00940000155692"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF23">
        <property type="entry name" value="ANOCTAMIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="880"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="11">
        <location>
            <begin position="118"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="10">
        <location>
            <begin position="338"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="971" mass="113212" checksum="CFA588BCC510D009" modified="2019-02-13" version="1">MHRLTGKTGEDSLIEMSPTDSFSDDVNGYHHHASSSTGSPEQGRSEFALTPDVRVESCESLNNSLASLAPSDHSDSPQFAPQTIEQINALTGFSRKRALFLKFRSRIDKQKYSKDSVFFRDGVRRIDFVLSYIDDKDDQRKQERRRVYESNLQKVGLELETEDKTESEDGKTYFVKIHAPWEVLATYADVLKIKVPFKVNDIPDNSEIPMNWLSTPFRLPGHIMNPEPDYFTAPFNKSKSDFFLIEDKETFFPPSTRNRIVYYILARCPYFKDECGDRDKKGIKRLLNNGTYTAAFPLHDSRYWTKSKDPNCESERFSLYKYWAKFFCFFKEQPLNLVRKYYGEKIGIYFAWLGFYTEMLFFAAVVGTICFVYGFLTYDDNEWSKEICSEEIGGNIVMCPLCDQKCTYWRLNITCNSSWQSHLFDNVATVFFAIFMGIWVTLFLEFWKRRQARLEYEWDLVDFEEEQQQLQLRPEYETKCTNRKLNRITQEMEPYLPITSKCARICLSGATVLLWISLIIACIIGVIAYRLAVYASFASIMKNNTATNLDVVAPYVTPQLATSVTASCINFVIIMILNLLYERVAIKITDMEIPKTHVEYENKLTVKMFLFQFVNYYSSCFYVAFFKGKFVGYPGNYTYMFGSSKLRNEECEPGGCLIELTTQLVIVMTGKQVWGNIQEALVPWLMNWWGSRKARSHPESLYSRWEQDYDLQGFGQLGLFYEYLEMVIQFGFITLFVASFPLAPLLALINNIIEVRVDAWKLTTQFRRPVAAKAHSIGAWEEILGGMAVLSVVTNAFIVAFTSDMIPRLVYMYAYRTHDELNMKGYINNSLSVFNISQFSQEERPEEYPSWFNSSITTCRYRDYRYPPDDKKRYEHNMQFWHILAAKLAFIIIMEHVVFMVKFFVAWMIPDVPSDVRARVKRERYLVQEYLHNYEVEKLKIQLSQNSNSDCTCTPMIYPSLSKHEVLSECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYX2</accession>
    <name>A0A3P9AYX2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome activator complex subunit 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYX2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002804"/>
    <dbReference type="Ensembl" id="ENSMZET00005002920.1">
        <property type="protein sequence ID" value="ENSMZEP00005002804.1"/>
        <property type="gene ID" value="ENSMZEG00005002201.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011433"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990111">
        <property type="term" value="C:spermatoproteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="2">
        <location>
            <begin position="234"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="320" mass="36572" checksum="7A98DBC0D0B4FA0F" modified="2019-02-13" version="1">MIDVALPHTRPTTSPHVAEFITRVLERLKPLTAEPEIHNHVHEENTQETDERTQAVKLLKTVLKWLMTSAGRTFTTPVQQQLQLLPLLFKIAPVEIDESYDEMKQDARTCLSLMSQGLLYPEHIPLVLAALEEMAGSRSWHARFSVLTYLQIMVFYNLFTLLSVPAEVLRIRKLVMQLLLDEQLEVRDMACTTLSGLLQCQFFPLDSSLQTQLQTLSQTSLPKARGELASTDLVRRHAGVLGLSACILSSPYDVPDWMPQILMDLSSHLNDPQPIEMTVKKTLSEFRRTHHDNWQEHRQCFTDDQLLVLTDLLVSPCYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZU8</accession>
    <name>A0A3P9AZU8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tropomodulin 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tropomodulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_023007995.1">
        <property type="nucleotide sequence ID" value="XM_023152227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZU8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003193"/>
    <dbReference type="Ensembl" id="ENSMZET00005003321.1">
        <property type="protein sequence ID" value="ENSMZEP00005003193.1"/>
        <property type="gene ID" value="ENSMZEG00005002464.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483315"/>
    <dbReference type="GeneTree" id="ENSGT00940000158695"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005865">
        <property type="term" value="C:striated muscle thin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000006">
        <property type="entry name" value="Tropomodulin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF8">
        <property type="entry name" value="TROPOMODULIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="377" mass="42432" checksum="5E64694543D43457" modified="2019-02-13" version="1">MALLRKEMEKYRDIDEDELLKKLSEEELQRLEDELEELDPDNALLPAGMRQKDQTKKAPTGTFQRDNLLAHLEKQAKEHPDKEDLVPYTGEKRGKAWVPKTRVDPIIESVTLEPELEEALSSATDAELCDIAAILGMHTLMSNQQYYEALASSTIVNKQGLNSVIQCTQYKPVPDEEPNSTDVEETLLRVKRNDPDLVEVNLNNIKNIPIPTLKAYAEALMKNTVVERFSIVGTRSNDPVAFALAEMLKVNTMLKSLNVESNFITGTGILALIESLQNNTTLLELKIDNQSQPLGNKVEMEIANMLEKNTTLLKFGYHFTQQGPRLRGSNAMMNNNDLARVVRSETDGSFTLTLSVPELERAFGKKFKSKTNKKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1I4</accession>
    <name>A0A3P9B1I4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Si:ch211-106h11.3</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562994.1">
        <property type="nucleotide sequence ID" value="XM_004562937.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B1I4"/>
    <dbReference type="Ensembl" id="ENSMZET00005003909.1">
        <property type="protein sequence ID" value="ENSMZEP00005003756.1"/>
        <property type="gene ID" value="ENSMZEG00005002911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477981"/>
    <dbReference type="KEGG" id="mze:101477981"/>
    <dbReference type="GeneTree" id="ENSGT00940000165172"/>
    <dbReference type="OrthoDB" id="365605at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000015">
        <property type="entry name" value="CYR61 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050941">
        <property type="entry name" value="CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012395">
        <property type="entry name" value="IGFBP_CNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017891">
        <property type="entry name" value="Insulin_GF-bd_Cys-rich_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043973">
        <property type="entry name" value="TSP1_CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348">
        <property type="entry name" value="CONNECTIVE TISSUE GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348:SF20">
        <property type="entry name" value="PROTEIN CYR61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19035">
        <property type="entry name" value="TSP1_CCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036495">
        <property type="entry name" value="IGFBP_rP_CNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00222">
        <property type="entry name" value="IGFBP_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018056340" evidence="7">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="94"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="8">
        <location>
            <begin position="301"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="397" mass="43849" checksum="3314150075F09DFF" modified="2019-02-13" version="1">MGTLLLFAALQVVTVASVTAECPVVCECPAVPPSCPPGVSSVPDGCGCCKVCAAQLNQDCHEGRPCDHHKGLECNYGNDVGRTHGICRAKAEGRSCEYSGRIYQNGENFRAGCKHQCTCIDGAVGCVPLCPSHVPLASPSCPAPQLVKVPGQCCLSIDCHKGTTVVPPVYRRPQPPAFPPYPPFIPYPVYPYPKPFPKPYRKFYTYKHKKEKDTLGNELVEAVRKWGKPRGNKHLAAWKQTSDECVVQTTSWSECSRSCGMGVSSRVTNDNAQCKMIKETRLCNIRPCSSMSIPVKKGRKCSRTHKAPEPHRLSYAGCRSTRLYRPNYCGVCRDGRCCSPRRTRTANVTFACPDGERFSRSVMFIQSCKCSDECNHLNEAVMPPQLWLYGDTHKFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B4Q1</accession>
    <name>A0A3P9B4Q1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tumor protein D52</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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                <person name="Malinsky M."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
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                <person name="Azzouzi N."/>
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    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF4">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="167"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="3">
        <location>
            <begin position="263"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="317" mass="36896" checksum="4DB901FA406E6093" modified="2019-02-13" version="1">MFFCHSCTLVRMSAHQTYVKLSEEKLIPKSDILSLLKTYNCYHEGKNFQLRTREEDGEFVLEGLLNIYWGLCRPIRLQMYDDNERFRFSRFTVAKQVSAESNNNSLDRETGPAGGDVGGQDEDDSPQLLRTRSDASFMRVQRRSKTHTARDLQRLRTHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTGQVLNLLLHKFRVENKAEEFVLYMVHESGERTRLRVGEYPLVTRVLYGPCEKISKIFITEADLGEEVTYDVAQYIKFEIPVLDSFVEKLKEEEEREIIKLTKKYSALKSMILHQLEDRAHTDDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B896</accession>
    <name>A0A3P9B896_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Apolipoprotein B</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="protein sequence ID" value="ENSMZEP00005006119.1"/>
        <property type="gene ID" value="ENSMZEG00005004759.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
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        <property type="term" value="C:low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034359">
        <property type="term" value="C:mature chylomicron"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:very-low-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006642">
        <property type="term" value="P:triglyceride mobilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.80.10">
        <property type="entry name" value="Lipovitellin-phosvitin complex, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052418">
        <property type="entry name" value="Apolipoprotein_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009454">
        <property type="entry name" value="Lipid_transpt_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015255">
        <property type="entry name" value="Vitellinogen_open_b-sht"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13769">
        <property type="entry name" value="APOLIPOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13769:SF6">
        <property type="entry name" value="APOLIPOPROTEIN B-100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06448">
        <property type="entry name" value="DUF1081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09172">
        <property type="entry name" value="Vit_open_b-sht"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01169">
        <property type="entry name" value="DUF1943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018299553" evidence="8">
        <location>
            <begin position="22"/>
            <end position="4368"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="9">
        <location>
            <begin position="37"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="4368" mass="487758" checksum="E9D491411D3B06E6" modified="2019-02-13" version="1">[encoded data, 4368 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8R5</accession>
    <name>A0A3P9B8R5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Angiopoietin-like 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004572825.2">
        <property type="nucleotide sequence ID" value="XM_004572768.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8R5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006275"/>
    <dbReference type="Ensembl" id="ENSMZET00005006564.1">
        <property type="protein sequence ID" value="ENSMZEP00005006275.1"/>
        <property type="gene ID" value="ENSMZEG00005004870.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101471072"/>
    <dbReference type="CTD" id="10218"/>
    <dbReference type="GeneTree" id="ENSGT00940000157064"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:fibrinogen complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:blood coagulation, common pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
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    </dbReference>
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        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
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        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018282966" evidence="5">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="6">
        <location>
            <begin position="117"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="342" mass="39580" checksum="37A6E404F3BD9702" modified="2019-02-13" version="1">MAKIYLSIVVLEVALLLLAETWAQNLKKRQALPKPSKGQCCDEVRSLKVQVANLTSLFEELSRKQETDMKKLVKQILDLDQQSRQQDVRVTEAESKYSEINNRVEIMQLQTAQSAPKTSSEAIYDCASLYSKNYKISGEYKLPKDEFLGTPEFTLFCDMETNGGGWTVIQRRSVGLTSFNRDWKQYKQGFGSIRGDFWLGNDNIFRLTRQPSTLRIDMEDWEGEKRYAEYGFFTVSNELNSYKLFLANYSGNAGDSLRYHNNTNFSTMNKDNDKCLDDCAARRKGGYWYNCCTDSNLNGVYYRYGNHIKNQDKNQDGITWYGWHGPTYSLKKVEMKVRPVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8S8</accession>
    <name>A0A3P9B8S8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36139"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:72745"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:36140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52112"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:90718"/>
            <dbReference type="ChEBI" id="CHEBI:136408"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:52113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52116"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:136409"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:52117"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:52108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65341"/>
            <dbReference type="ChEBI" id="CHEBI:136407"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:52109"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_004563663.1">
        <property type="nucleotide sequence ID" value="XM_004563606.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004563664.1">
        <property type="nucleotide sequence ID" value="XM_004563607.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004563665.1">
        <property type="nucleotide sequence ID" value="XM_004563608.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014264082.1">
        <property type="nucleotide sequence ID" value="XM_014408596.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8S8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006290"/>
    <dbReference type="Ensembl" id="ENSMZET00005006578.1">
        <property type="protein sequence ID" value="ENSMZEP00005006290.1"/>
        <property type="gene ID" value="ENSMZEG00005004849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487205"/>
    <dbReference type="KEGG" id="mze:101487205"/>
    <dbReference type="GeneTree" id="ENSGT00940000154508"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05927">
        <property type="entry name" value="LC-FACS_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF28">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="15">
        <location>
            <begin position="111"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="16">
        <location>
            <begin position="566"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="693" mass="76698" checksum="99D13580D0203E5E" modified="2019-02-13" version="1">MEEFIQNLPDLDVSCYVRNMSTPVLVSIGAVVAATTYYLATRSRPLPQVCDLQMQSVEVQGGDLARRSVLLTTDSPLTHIYDDATTLYEFFLRGARVSSNGPCVGSRKPKQPYEWISYREVIEQAENLGSAFLHKGNSKTADSHIGIFSQNRPEWTISELACYTYSLVSVPLYDTLGTEAISYIIDKASISTIVCDVMDKVNLVLDCINNTKHSVRTIVLMESPNTSLIEQGQQAGIHILSLQEMMAIGKANHQEPLPPQPKDMAVICFTSGTTGKPKGAMLTHGNIVSNCSAVIKITGTTCPVLPNDIHLSYLPLAHMFERVVQGVMLIHGARIGYFQGDIRRLSDDMKVLKPTVFPVVPRLLNRMYDKIFGLANSPWKRWLLEFAFKRKHSEIMKGIIRKDSIWDKLIFNKVQASLGGCVRLMITGAAPISPVVLTFLRAALGCQFYEGYGQTECTAGCTVTMPGDCTAGHVGAPLPCNIVKLVDVPEMNYLAENGEGEVCVKGANVFQGYLNDPERTAETIDADGWVHTGDIGKWLPNGTLKIVDRKKHIFKLAQGEYIAPEKIENIYMRSDAVAQVFVHGDSLQACLVAVVVPDPDFLSDWTRRTLGLQGSYLELCGRAEVKAAILEDMLRLGKAGGLKSFEQVKAICIHTELFSIENDLLTPTMKAKRNELRQYFRSQIDELYAGIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9P8</accession>
    <name>A0A3P9B9P8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial fission factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the Tango11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570582.1">
        <property type="nucleotide sequence ID" value="XM_004570525.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9P8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006605"/>
    <dbReference type="Ensembl" id="ENSMZET00005006903.1">
        <property type="protein sequence ID" value="ENSMZEP00005006605.1"/>
        <property type="gene ID" value="ENSMZEG00005005094.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485256"/>
    <dbReference type="KEGG" id="mze:101485256"/>
    <dbReference type="GeneTree" id="ENSGT00390000009776"/>
    <dbReference type="OrthoDB" id="5986838at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090314">
        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039433">
        <property type="entry name" value="Mff-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008518">
        <property type="entry name" value="Mff/Tango-11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501:SF17">
        <property type="entry name" value="MITOCHONDRIAL FISSION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16501">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05644">
        <property type="entry name" value="Miff"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mff-like" evidence="12">
        <location>
            <begin position="13"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="288" mass="32304" checksum="B702652516C45F2A" modified="2019-02-13" version="1">MSGATFNTPSAEVAEMNRIHFELEYTEGISQRMRIPETLKVAPESQAGSIPLQQPLPTHTALMQVPERIVVAGDEGDPRFACPRDLDLIQSIPPVDLLNMKAPPRVLTLTEQPLDSLETDQTVNSQRNPSQAASFHGRPRRERSASENVSGRHSSQISRGDVSVTPSPSAPPVRLCPPLCSPEDANINLFTAAGLLSYIQSTTRRAYQQVLEVLDDSHRRTHLDLALDLNPDESGLVDASSLRRQIVKLNRRLQLLEEENKERSKREVILYSATVAFWLINTWIWFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAD8</accession>
    <name>A0A3P9BAD8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TRIO and F-actin binding protein b</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004563096.1">
        <property type="nucleotide sequence ID" value="XM_004563039.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAD8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006873"/>
    <dbReference type="Ensembl" id="ENSMZET00005007175.1">
        <property type="protein sequence ID" value="ENSMZEP00005006873.1"/>
        <property type="gene ID" value="ENSMZEG00005005290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479177"/>
    <dbReference type="KEGG" id="mze:101479177"/>
    <dbReference type="CTD" id="790927"/>
    <dbReference type="GeneTree" id="ENSGT00940000157340"/>
    <dbReference type="OrthoDB" id="9942268at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13275">
        <property type="entry name" value="PH_M-RIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000133">
        <property type="entry name" value="myosin phosphatase Rho-interacting protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039597">
        <property type="entry name" value="M-RIP_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF10">
        <property type="entry name" value="TRIO AND F-ACTIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="295"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="539" mass="61754" checksum="675809DDAB439D92" modified="2019-02-13" version="1">MTPDLLNFKKGWMSKLDERGEWKKHWFVLTDAGLKYYRDSTAEEKDDLDGEIDLKSCVNVSEFDVEKNYGFQIQTREAAFMLSAMTAGIRRNWIEVLKKCIRPSSSPDITQLPDSDKENSHDRVLLSSRRPTSRHGEAQSEVPASTPSSHRRFDYVELSPVPASSSLRLASQREAGEGQGREHSQRQEEKNTSSQWDAVLSRKGTGSNQKLRMEEEIEKKWTEFEQMPLKEMSSLPSVGSRASGQTANEALQREVASLRQQVEQLQRKGGEGGGGGVRGGCGPEAPCSRSLLAMERAHRQALEELQKQHDRQVKELEAQKDRLLLQEAQDTARVMEALKKKHKEELEREVEKVKRLSSGAVDSQTLRALHQAEAQASQRELAGLSERYSQKCLELNRAEQNNAEREREISRKERDMEQLRKENQDLKARLTEEMKRIQSAIRDHGSEDKNRMPCELEVLLRMKDNEIQYLQKEISCLRNELQFLNMEKQLACKRYGELQEELSGMKGRNEREIQSLKEHLKLAMAALQEGQKLGNSLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCS3</accession>
    <name>A0A3P9BCS3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid droplet-regulating VLDL assembly factor AUP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ancient ubiquitous protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AUP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563244.1">
        <property type="nucleotide sequence ID" value="XM_004563187.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCS3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007688"/>
    <dbReference type="Ensembl" id="ENSMZET00005008006.1">
        <property type="protein sequence ID" value="ENSMZEP00005007688.1"/>
        <property type="gene ID" value="ENSMZEG00005005874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469020"/>
    <dbReference type="KEGG" id="mze:101469020"/>
    <dbReference type="CTD" id="550"/>
    <dbReference type="GeneTree" id="ENSGT00390000016110"/>
    <dbReference type="OrthoDB" id="1854593at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14420">
        <property type="entry name" value="CUE_AUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000049">
        <property type="entry name" value="ancient ubiquitous protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048056">
        <property type="entry name" value="AUP1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486">
        <property type="entry name" value="ANCIENT UBIQUITOUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486:SF96">
        <property type="entry name" value="LIPID DROPLET-REGULATING VLDL ASSEMBLY FACTOR AUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="10">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="411" mass="45923" checksum="90F017A34BBBE3D8" modified="2019-02-13" version="1">METRGIEDMFDFRRFPKDAVVLLLLLIYFPVGISLMFIRIFIGVHVFLVSCALPESFIRRFVVRVMCSVLGMHVRQKNPRSRDKNTKLYICNHVTEFDHNIINLLTPCSTPQLDGSTGFVCWARGFMEIHAGSGAIGESLQSYCSAEGTTPLLLFPEEDTTNGRAGLLKFSSWPFSLTESIQPVALRVTRPLISLSTPESSWLTELLWTFFVPWTVYHVSWLPTVSRQDGESTQEFANKVQELLAAELGLVATKITKADKAEHIKRTRHIVPQTTTSVTPGSIGLGFMSLGTDDRRIAKMAQQVKDVLPHVPLNVITKDLAKTNCVDTTITNLLENKEETSMEAAGISTFGPSKISSYSSGPASTLKPAAKTFGKSPTDRHLSLQERKEALYNFARRRYIEKHGLEQEDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDD7</accession>
    <name>A0A3P9BDD7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Complement C3-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005007771"/>
    <dbReference type="Ensembl" id="ENSMZET00005008089.1">
        <property type="protein sequence ID" value="ENSMZEP00005007771.1"/>
        <property type="gene ID" value="ENSMZEG00005004963.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154063"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="complement C3 isoform X1"/>
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        <property type="entry name" value="Complement component C3"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.91.20">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000020">
        <property type="entry name" value="Anaphylatoxin/fibulin"/>
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    <dbReference type="InterPro" id="IPR018081">
        <property type="entry name" value="Anaphylatoxin_comp_syst"/>
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    <dbReference type="InterPro" id="IPR041425">
        <property type="entry name" value="C3/4/5_MG1"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
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    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
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    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
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    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
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    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
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    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
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    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
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    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF81">
        <property type="entry name" value="COMPLEMENT C3"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01821">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17790">
        <property type="entry name" value="MG1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
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    <dbReference type="SMART" id="SM00104">
        <property type="entry name" value="ANATO"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47686">
        <property type="entry name" value="Anaphylotoxins (complement system)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01178">
        <property type="entry name" value="ANAPHYLATOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018155512" evidence="5">
        <location>
            <begin position="24"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphylatoxin-like" evidence="6">
        <location>
            <begin position="676"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="1488"/>
            <end position="1637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1640" mass="185505" checksum="294F0374F47D717F" modified="2019-02-13" version="1">MYRSQLLLLDFVGFFCFISLASGSPMEVMSAPNLLRVGTEENIFVEIQDNAGEKNVNVNIIVRNFPRKDIMLASTTVTLTKENKFQGIGKIMIPAERFSNDPNIKQYVHLQGEFGTQTLEKIVLISLQYGYIFIQTDKTIYTPSTTVFYRIFAMRPNMEPVDKNYQPGTDTSVVVDINPDGIILESKLVLVVSGIYYGSYFLPEIVSTGTWKVVSKFNTNLKQTFEAEFEVKEYVLPSFEVKLTSQVPFFYVDSDELTINIKATYLFGKKVDGTAFVVFGVLVGNTKNGIPSSLQRVEINEGEGTVKLKREHIAQTFPNINDLEGNFIFAAVSVLTESGSEMVEAELRGIQIVKSPYTINFKKTPKYFKPGMSFDVTIQVLNPDNTPAKDIPVVVNPGEVKGHTADNGMAKLSINTLNCRLATTAVENILPARQRSATMIVTPHTSRNYIHIGLETAEVKLGQNLKFSLNLNRNEEYDITYLILSRGQLVKHDRFRAERQILISHNVLITKEMLPSFRIIAYYHVNTEVVSDSVQVDIQHSCVGDLKLEEKEKKHNNYKPRGKFELKVTGDPGATVGLVAVDKGVYVINNKHRLTQKKIWEIIAAYDTGCTPGGGKDSMNVFYDAGLLFVASTTSGTPHRTDLKCPATSRRKRSTTLIDLRTSLISKYQDKEQIECCLDGMKDVPVPYICERRRDYIVGGPGCAEAFLHCCKEMEKVHVDRKVEALKLARIFKNSFSSYKNYDISVRTSFPESWLWINFTLPNCTQNIKNCRTTYEKNDIPLPDSITAWHFTGISMSRTHGICVNDDLEILVQKTFFIDLRLPYSAVRGEQLEIKAILHNYEEELIRVRVDLKEETNLCSAAHKRGKYRQEVTVGSGTTRAVAFTIIPMKEGLFPIEIKAAVRDGGSDGIRKMLRVVNPLTSYLSLRLDGKQVEIIKSAIPETDMVPDTAARTQIFLSGREQMSTLLENAISGKSMGTLIKQPGGCGEQNMASMTLPVIATMYLDKTNQWEFVGFEKRNEALQHITTGYTTELTYRKQDGSFAVFPYKDGSTWLTAYVAKVFAMAYYLIRVDEDVICDAIKFLILNTQQPDGMFKEVGYVYSQSMRSDLLGTDSDASMTAFCLIAMQESREICRSSVNSLQNSINKAVAYLEKRLPSLINPYSVAMTSYALANENKLNKEILFKFISSDRTHWNVRGERYYTLEATAYALLALIKAEAYEEATPIVRWLGKYQQGEGGYGSTQATIMVYQASSEYWINAKEPEYNVDVDILLPGRTMTDKYSFSKANRFTTRTSKFPAINKDIQVNATGNGEAVLKIMSLYYALPKVLEKDCELFNLSVQIVPEKLDEDEKIYKLTIEVLFKEERNASMSIIDVGLPTGFTFNKNDLDALSKSHSRIISRYESNTDLSERGSLIIYLNKVRSSVQPEIITFRIHSTMEASFLQPTAVSVYEYNNKKPCVKFYHPERKNATLLSLCSGRKECVCAEENCSFQRKNEVGNEDRIAKACEVAKDGSIDFVYKVRVEELEPYWSTDFYRVQILEVIKEGNTDVGPEGQPRIFISSQHCRKAQGLTASKTYLIMGTSKDIYKDDEKRIYQYVLGERTWIEYWPTTAECQTREYHSTCVGIQDLVQVYKLHGCPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDV4</accession>
    <name>A0A3P9BDV4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell surface A33 antigen</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDV4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007936"/>
    <dbReference type="Ensembl" id="ENSMZET00005008256.1">
        <property type="protein sequence ID" value="ENSMZEP00005007936.1"/>
        <property type="gene ID" value="ENSMZEG00005006050.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160248"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042474">
        <property type="entry name" value="A33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44969">
        <property type="entry name" value="CELL SURFACE A33 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44969:SF1">
        <property type="entry name" value="CELL SURFACE A33 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018011549" evidence="2">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="133"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="259" mass="28404" checksum="1E521D5171EE3D08" modified="2019-02-13" version="1">MNNTDLFDFVFMSMTVLTGVGAIDVTMPQSQYEFARGDNITLPCSFKSAININTAEAVTPIITYYYPIKKTSITPPYKGRVSLDVDVLNGKANLKLSSISLADNKEFECHVQIPDDEDGNQAASARLVVLVAPSTPVCKIQRTAQYGQDITLTCASAGGSPMPTYSWKRYCEHNQPVPQDPQITDKDGILSLYNISKDTSGFYICTSQNKLRAATCNLTLSLMPPSVNAITTGGIIGRVLAYLIFLIIIIIIFFFCQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEM7</accession>
    <name>A0A3P9BEM7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protein Mpv17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein Mpv17</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004568451.1">
        <property type="nucleotide sequence ID" value="XM_004568394.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEM7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008226"/>
    <dbReference type="Ensembl" id="ENSMZET00005008553.1">
        <property type="protein sequence ID" value="ENSMZEP00005008226.1"/>
        <property type="gene ID" value="ENSMZEG00005006257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466209"/>
    <dbReference type="KEGG" id="mze:101466209"/>
    <dbReference type="CTD" id="4358"/>
    <dbReference type="GeneTree" id="ENSGT00940000160891"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050935">
        <property type="term" value="P:iridophore differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901858">
        <property type="term" value="P:regulation of mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048742">
        <property type="term" value="P:regulation of skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090207">
        <property type="term" value="P:regulation of triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="177" mass="19865" checksum="C158CDFF57EAE095" modified="2019-02-13" version="1">MAGLWRGYQVLMTKYPWTVQIVTAGSLVGVGDVISQQLIERRGLANHNVQRTAKMMSIGFFFVGPVIGSWYKVLDRLVVGGTKSAAMKKMLVDQLCFAPCFLGAFLCISGALNGLTVEENVTKLRRDYTDALISNYYLWPPVQIANFYFIPLHHRLAVVQVVAVAWNSYLTWKANKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BG85</accession>
    <name>A0A3P9BG85_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BG85"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008898"/>
    <dbReference type="Ensembl" id="ENSMZET00005009241.1">
        <property type="protein sequence ID" value="ENSMZEP00005008898.1"/>
        <property type="gene ID" value="ENSMZEG00005006733.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175713"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF111">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018244043" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="180" mass="19989" checksum="1DE335E668469FF9" modified="2019-02-13" version="1">MRSFILITALSLCSLSWISTSEFQTVEVQHGDEVTLQCSNISAYPTQTDWFRVVNKTKPSCVSSMYGSDSEASFCHGFRNRNFNMSSNVSFVFLQIKRVDLSDAGLYFCGLYIKSSLVPVVFATLAVFFVMAVIGLAVKINVDSVDLNSAVLRLHPQTPRSRRPAKETRVETHVVYAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BI30</accession>
    <name>A0A3P9BI30_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BI30"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009552"/>
    <dbReference type="Ensembl" id="ENSMZET00005009912.1">
        <property type="protein sequence ID" value="ENSMZEP00005009552.1"/>
        <property type="gene ID" value="ENSMZEG00005007231.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271821"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015095">
        <property type="entry name" value="AlkB_hom8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09004">
        <property type="entry name" value="ALKBH8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="513"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="924" mass="105215" checksum="7BBC6EAF0C886A62" modified="2019-02-13" version="1">MEFIHSHKIPEEVARRPGAHWITIPAGGRRRRRRERRRKRGCRAGVLTRLRRKPFKPPLPSLYLSNVRSLANKMDELRLQITTDNHIKNSCILLITESWLHQSIPDSAIELAGYTAQRQDRTNNSGKRKGGGICIYVNNSWCTNTVIIDRHCSPDIEYLTVKCRPIYLPREFTVVVITTVYIPPDANTKVALALLHTNINNKLNKYPDAVHIIAGDFNQVDLKTAIPNFHQHVKCATRGANTLDKVYSNIKKGYRARPLPHLGQSDHLSLLLIPAYAPIRKTASTITKTITTWPEGASQQLQDCFDRTNWNIFQHQDLEMFTNSVLCYIKHCIDTVTVDKQIRVYTNQKPWMTREVQQLLKERNSAFRSGSRESYSRARANLKKGIKKAKADYRKKIENHLESKNSRLVWQGVQQLTNYKSKSGMAEGDPALAEELNIFFTRFEVTAPYASEEQLHHTAHSSSTIITLEEHEVRCTLRAVNPRKAAGPDGVPGRVLRDCADQLAYIFTRIFNQSLEQSNVPPCLKTSTIIPLPKKSHISSLNDYRPVALTPVVMKCFEKLVRYHITAALPSSLDPHQFAYRANRSTEDAIATALNVALTHLERQGSYVRMLFVDYSSAFNTILPYKLDAKLKDLGLPHSTCKWINSFLTDRRQRVRVGCYTSPALNLSTGSPQGCVLSPLLYSLYTHDCTPAIVKFADDTTVVGLISGGDESAYRDEVERLSSWCKDNNLLLNTKKTKELIIDYRRHKTEIQPLIISDDCVERVADFRFLGVSIEGNLSWSVNTSELLKKTQQRLYFLRVLRKNNITQRLLVSFYRASIESILTYCIGIWYASCTVAQRKALQGVINAAQRTIGCPLLKLKDLHSSRCLKRAHNIIKDTSHPGHSMFELLPSGKRYRTTYTRTNRLKHSFYPIAISCLNATKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJI9</accession>
    <name>A0A3P9BJI9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB/POZ domain-containing protein KCTD9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544171.1">
        <property type="nucleotide sequence ID" value="XM_004544114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJI9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010068"/>
    <dbReference type="Ensembl" id="ENSMZET00005010434.1">
        <property type="protein sequence ID" value="ENSMZEP00005010068.1"/>
        <property type="gene ID" value="ENSMZEG00005007601.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468158"/>
    <dbReference type="KEGG" id="mze:101468158"/>
    <dbReference type="CTD" id="541442"/>
    <dbReference type="GeneTree" id="ENSGT00940000154314"/>
    <dbReference type="OrthoDB" id="9989223at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18368">
        <property type="entry name" value="BTB_POZ_KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17073">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000044">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.80:FF:000002">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 9a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021789">
        <property type="entry name" value="KHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11834">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51490">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="KHA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="91"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="389" mass="42629" checksum="833EC9889A698108" modified="2019-02-13" version="1">MRRVTLFVNGTCKNGKVVAVYGTLSDLLSVASNKLGIKASCLYNGKGGLIDDIALIRDDDVLYVSEGDPFIDPQNEAKITSDPLAAHTDWLTLNIGGRLFTTTRSTLVSKEPESMLAHMFREKDVWGNKQDEHGAYLIDRSPEYFEPILNYLRHGQLIINEGINIRGVLEEARFFGIEQLAEQLEVAIKNSQPPEDHSPISRKEFVRFLLATPTKSELRCQGLNFSGADLSRLDLRYINFKMANLSRCNLTHANLCCSNLERADLSGANLDGANLQGVKMLCSNAEGASLKGCNFEDPSGLKANLEGANLKGVDMEGSQMTGINLRVATLKNAKLKNCNLRGATLAGTDLENCDLSGCDLQEANLRGSNVKGAIFEEMLTPLHMSQSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLH9</accession>
    <name>A0A3P9BLH9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase mitochondrial F1 complex assembly factor 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with ATP5F1B; involved in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). Interacts with FMC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562372.1">
        <property type="nucleotide sequence ID" value="XM_004562315.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLH9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010775"/>
    <dbReference type="Ensembl" id="ENSMZET00005011152.1">
        <property type="protein sequence ID" value="ENSMZEP00005010775.1"/>
        <property type="gene ID" value="ENSMZEG00005008102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475881"/>
    <dbReference type="CTD" id="91647"/>
    <dbReference type="GeneTree" id="ENSGT00390000009492"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3580.10:FF:000001">
        <property type="entry name" value="ATP synthase mitochondrial F1 complex assembly factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2180.10:FF:000001">
        <property type="entry name" value="ATP synthase mitochondrial F1 complex assembly factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="277" mass="32023" checksum="5252486A9C1D49C7" modified="2019-02-13" version="1">MRTFRTQTSRSKVCPRNRYYECVARYSAATAERKRFYQDVSISQSEGGLYEINLDQRKLKTPGGKLFTVPNEALAIAVATEWDTQRDTLKFYTMHLTTLCNTALDNPTQRSKEQMITAALKFLETDTICYRVDEPHGLVELQRNEWDPVLQWIEKRYNVTIGSSASILGPEIPEATKDTLRQHLKSHNFWSLTGLEYVITQLKSIVLSLGMIDRHLSVEQAVLLSRLEEEYQIRRWGNVEWAHDYDMYELRARTAAGALFVHLTSESSTVKHKLLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLQ0</accession>
    <name>A0A3P9BLQ0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prominin 1 b</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLQ0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010855"/>
    <dbReference type="Ensembl" id="ENSMZET00005011232.1">
        <property type="protein sequence ID" value="ENSMZEP00005010855.1"/>
        <property type="gene ID" value="ENSMZEG00005008121.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063586"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071914">
        <property type="term" value="C:prominosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF8">
        <property type="entry name" value="PROMININ-1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018046339" evidence="9">
        <location>
            <begin position="19"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="888" mass="98715" checksum="3B1E4BC98829DBDF" modified="2019-02-13" version="1">MLWTRWLVLLLCWGATGSEEQADERGAVPAEVRSDSRRERSPPPVEPLDFGFVPAAVYDTHAYYEPGSMGILFHMVHAFLYIIQPNPFPKDLIVKVIQQNMGGIKIEEWRKPENVVLLLQWIQYESGFLICATFGVVFVVLIPVIAMCFCMCRCCDNCGGEMHQRQRKNADCHRGFYTASLVATTIFIIVGVLIALAANHNISSQVKSTRRLINTNMRDLKTFANNTPAQVDYLTAQYTTAKNKVLSDLDNIGPLLGGRIHIQLEKSVIPSLDTALRMAGAKVESAIKAMRETKEALENVSSSLEVLQDGVGKLQASLSGERASLSNTLSDPACTNGAVSHTCNTIRSTLSQLGINADFSKIPDVNHALANVNTVLKTDLSNIVQKGYASFNDTPRLVKEQTKNIVAALPRVKGMLDKIGAEIIGFSKMFPVEASLANFTIFLNERHKAIESYYPQIDQMDFYRWIACVAVLCMVVLVMAFNILGLLCGNCGYDKQASPTTRGCLSNTGGNLLMAGVGFSFIFAWVLMVIVTTLFVVGGNVEKLICEPLANRQLFKIIDTPFLVHPEKRNFLPGMLFQNPNIDLTLGGMYRECYDNNGLYHALQLETMFNINSFLNRTVYNRDLAKVFDSVQVDLQGITLLEQAGRDNLINFANSGIGQIDFQVYLTEVNKGVTLIDLLSFCSDLEGQADQLPRGALENALRGHASSIRFIHREQVVPLEQAMKYVRARSTLHQSVKQLQKTSNDLPVKVTNVLSAIDAAEYLIAHNASHVVKQETKAYVQGLVGYFKQYTEWVKNSLTTEVAQCKPISNIVDSMEIVGCSFIIDSLNTFWFGLGSCCILLIPSIIFSVKLAKYYRRMDTEDVFEDSPYSDTLTRFPRASAPPSYSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BP87</accession>
    <name>A0A3P9BP87_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine N-acyltransferase-like protein</fullName>
            <ecNumber evidence="1">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BP87"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011753"/>
    <dbReference type="Ensembl" id="ENSMZET00005012159.1">
        <property type="protein sequence ID" value="ENSMZEP00005011753.1"/>
        <property type="gene ID" value="ENSMZEG00005008815.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183133"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047961">
        <property type="term" value="F:glycine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010313">
        <property type="entry name" value="Glycine_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015938">
        <property type="entry name" value="Glycine_N-acyltransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298:SF17">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298">
        <property type="entry name" value="L-COA N-ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06021">
        <property type="entry name" value="Gly_acyl_tr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="128"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="269" mass="31169" checksum="78C7E0F56A18BE11" modified="2019-02-13" version="1">MKVLSRDELQVAEGVLLKHLPKSYKVYGFLYGINRNKPTTLEVVVDAWPDFKVIICRPDPENKRASIFMKKVTYYSTDEQSLRKMLTDENAVDWSTYFMIGGLDVSHAPVLKQVSCDRRVKYKTDILVHLLYLQDTNYLHMPAINRYNLKSICHMKYFGGDEKGYRKIENLISNFPSCCITDSQGQPVSWILVCDYCALGMLYTLPEHRGKGYAKIVISTLAKKLHAEGYPVFCYIEEDNVLSYKLFKNMGFIEDPSYRAAWLEFNFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSB1</accession>
    <name>A0A3P9BSB1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Spastin</fullName>
            <ecNumber evidence="10">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SPAST</name>
        <name evidence="10" type="synonym">SPG4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer. The homohexamer is stabilized by ATP-binding. The homohexamer may adopt a ring conformation through which microtubules pass prior to being severed. Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Microtubule organizing center</location>
            <location evidence="10">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <text evidence="10">Forms an intramembrane hairpin-like structure in the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AAA ATPase family. Spastin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSB1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012521"/>
    <dbReference type="Ensembl" id="ENSMZET00005012965.1">
        <property type="protein sequence ID" value="ENSMZEP00005012521.1"/>
        <property type="gene ID" value="ENSMZEG00005009373.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156258"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:cytokinetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0031117">
        <property type="term" value="P:positive regulation of microtubule depolymerization"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02679">
        <property type="entry name" value="MIT_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19524">
        <property type="entry name" value="RecA-like_spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000036">
        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spastin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
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    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017179">
        <property type="entry name" value="Spastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF86">
        <property type="entry name" value="SPASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="10">
        <location>
            <begin position="36"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="MIT" evidence="13">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="276"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="284"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="519" mass="57533" checksum="B688BC8A558C255D" modified="2019-02-13" version="1">MDKSSTYKLNKIGDKIPPCLTPLLTPKGAEILLPHLTCISARVMSTKTNASKPKDSAEVIKNIHKQAFEYISKALKIDEDDTGEKKEAVQWYKKGISELERGIAIELTGQGEQYDRAKRLQDKMVTNLTMAKDRLTLLGELALIIFIKVMYAEKACRRSSNSTRRCFHHHQTLHSSTFLMCNAFWDNLIPAKTTARVGKTQNGRPAAVKQPPKRDMKNFKNVDSKLANLIMNEIVESGATVSFDDIAGQDLAKQALQEIVILPALRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSVIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGVQSGKDDRVLVMGATNRPQELDEAILRRFAKRVYVTLPDEKTRFTLLKNLLGKHGSPLSQNELSCLAKVTAGYSGSDLTALARDAALGPIRELGPDQVRNMAAAEVRNIKKKDFEDSLKRIKPTVSPATLNMYTKWNKDFGDTSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSU5</accession>
    <name>A0A3P9BSU5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553799.1">
        <property type="nucleotide sequence ID" value="XM_004553742.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSU5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013028"/>
    <dbReference type="Ensembl" id="ENSMZET00005013469.1">
        <property type="protein sequence ID" value="ENSMZEP00005013020.1"/>
        <property type="gene ID" value="ENSMZEG00005009784.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005013477.1">
        <property type="protein sequence ID" value="ENSMZEP00005013028.1"/>
        <property type="gene ID" value="ENSMZEG00005009784.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476149"/>
    <dbReference type="KEGG" id="mze:101476149"/>
    <dbReference type="CTD" id="51650"/>
    <dbReference type="GeneTree" id="ENSGT00390000011401"/>
    <dbReference type="OrthoDB" id="5980584at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="106" mass="12483" checksum="A8553342824F73BB" modified="2019-02-13" version="1">MAGLSSYALRMARLSSQIFGEVVHPTDPKSMKVVQLFQEPPTAKRKEVYDWYPHHKIYYAVTQKLRFMGLFRDEHEDFKEEMRRLRKLRGKGTPKKGEGKRAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSY6</accession>
    <name>A0A3P9BSY6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSY6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013065"/>
    <dbReference type="Ensembl" id="ENSMZET00005013514.1">
        <property type="protein sequence ID" value="ENSMZEP00005013065.1"/>
        <property type="gene ID" value="ENSMZEG00005009817.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009571"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF96">
        <property type="entry name" value="GRANZYME A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017962092" description="Peptidase S1 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="36"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="259" mass="28673" checksum="1525C5D2D26182D4" modified="2019-02-13" version="1">MKAKSSVVSRCGGIALFTLLSLLVSGCASGDIEKRIVGGVSCNEDRQYHVQIDSVQGGMTCGGALINTRWVITASHCREWCLKLVIPPKNLEQNIDPKQQFTFKDGDQPHDIMLIKLNEDVNPKLPTIRLPPAEGCQKPNMNDPVQIGGWGFKTFLEIEISLIMLYLISSETSNPKNLKCAMTEIVQCGENDKPDSKYFSDESTTMCAHKPGVESSVEYNSILHGIIVSNPVDKCANPIVMLNICRYRQWIADTMLNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTH0</accession>
    <name>A0A3P9BTH0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTH0"/>
    <dbReference type="Ensembl" id="ENSMZET00005013649.1">
        <property type="protein sequence ID" value="ENSMZEP00005013199.1"/>
        <property type="gene ID" value="ENSMZEG00005009915.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282517"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:003074">
        <property type="entry name" value="Immunoglobulin heavy variable 11-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="93" mass="10703" checksum="68402924D89C626C" modified="2019-02-13" version="1">PAVKRPGESHRLTCTTSGFNFGGYSMHWIRQAPGKGLEWIAYIQYNSAYIYYSQSVQGRFTISRDNSKQQVYLQMNSLKTEDSAVYYCARDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVL4</accession>
    <name>A0A3P9BVL4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GIPC PDZ domain containing family, member 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GIPC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559592.1">
        <property type="nucleotide sequence ID" value="XM_004559535.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004559593.1">
        <property type="nucleotide sequence ID" value="XM_004559536.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVL4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013676"/>
    <dbReference type="Ensembl" id="ENSMZET00005014143.1">
        <property type="protein sequence ID" value="ENSMZEP00005013676.1"/>
        <property type="gene ID" value="ENSMZEG00005010292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472667"/>
    <dbReference type="KEGG" id="mze:101472667"/>
    <dbReference type="CTD" id="10755"/>
    <dbReference type="GeneTree" id="ENSGT00390000003420"/>
    <dbReference type="OrthoDB" id="6509831at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048844">
        <property type="term" value="P:artery morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001946">
        <property type="term" value="P:lymphangiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002040">
        <property type="term" value="P:sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21180">
        <property type="entry name" value="GH2_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000097">
        <property type="entry name" value="PDZ domain-containing protein GIPC1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055349">
        <property type="entry name" value="GH2_GIPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056814">
        <property type="entry name" value="GIPC1-3_GH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017379">
        <property type="entry name" value="GIPC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259:SF4">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN GIPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12259">
        <property type="entry name" value="RGS-GAIP INTERACTING PROTEIN GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25083">
        <property type="entry name" value="GIPC1_GH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25082">
        <property type="entry name" value="GIPC1_GH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038083">
        <property type="entry name" value="UCP038083_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="337" mass="36585" checksum="92D5B8C467F13BC0" modified="2019-02-13" version="1">MPLGLGRRKKASPLVENEEAEPIRAGLNVPGMEGIDGGVVGLGEGATSEGLPPPPNSMRPRLIFHTQLAHGSPTGRIEGFSNVRELYAKIGEAFGIPPSEVMFCTLNTHKVDMDKLLGGQIGLEDFIFAHIKGQRKEIEVFKGEDALGLTITDNGAGYAFIKRIREGSIIHQIQVINVGDMIESINGHRLIGCRHYEVAKMLKELPKGKEFTIKLVEPLKAFDMISQRSGGSRSASGVQLGTGRGTLRLRSKGPATVEELPSAFEEKAIEKVDDLLESYMGIRDSELAATMVELGKDKKNPDEFAEALDETLGDFAFPDEFVFDVWGAIGDAKVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVN3</accession>
    <name>A0A3P9BVN3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ddb1 and cul4 associated factor 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004539989.1">
        <property type="nucleotide sequence ID" value="XM_004539932.5"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005014045"/>
    <dbReference type="Ensembl" id="ENSMZET00005014517.1">
        <property type="protein sequence ID" value="ENSMZEP00005014045.1"/>
        <property type="gene ID" value="ENSMZEG00005010598.1"/>
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    <dbReference type="KEGG" id="mze:101470056"/>
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    <dbReference type="GeneTree" id="ENSGT00950000182900"/>
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        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF43">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
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    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="614"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="453"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
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        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="801" mass="88106" checksum="87CE3C0E03B07A6D" modified="2019-02-13" version="1">MKELKGCAMRSSLGFLSRRELTGQPLLKEEFQRRRLAGCTSLYKKDMLGHFGCVNAIEFSNNGGEWLVSGGDDRRVLLWHMEKAIHGRSKPVKLKGEHLSNIFCLAFDSTNKKVFSGGNDEQVILHDVERRETLNVFLHIDAVYSLSVSPVNDNVFASSSDDGRVLIWDTREPPHGEPFCLASYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPRSSLLRYGGSMSLQSAMSVRFNSTGTQLLALRRRLPPVLYELHSRLPSFQFDNQGYFNSCTMKSCCFAGDKDQYILSGSDDFNLYMWKIPKDPEAGGPGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKVIKVWSPYQQPDSLGDLEGRVEDKSRSLYTHEEYITLVLNSGSGLSHDYVSQSIQEDPRMMAFFDSLVRREIEGWSSDSDTDLSEEAIMQLHARGRRSTRTTPTAPTAASAAGHHSNSDNSSSSSSLAGPDASGAEEQAGDEGEERPRRRSRHQRHQSGFLVNEDSDSSEFWLDPMPRPRSPSPRDNSTISSPTSSPSLPAGASSSSTSTSSSSSDDEERRSAVRRRNVMRRRRMHVVSRAGDRPESVQALFSAIDSCSYPSISIDDLSSSSSGEEQNALEIKPRTGGATEEEKCLSPSDFVCLSPVMSPESQENEEGSDRTELERHPAASPQSLDGCRTEGRAATEPVLDSSDSGEACGSSPAVDRTSQSRCTLGVNGQHRTVAPMGEYTTEGPHVASDPEEETGVPPEDKWPQREKVPALSALKRTHVGSDEAESASSPSEKKLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVP0</accession>
    <name>A0A3P9BVP0_9CICH</name>
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        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559767.1">
        <property type="nucleotide sequence ID" value="XM_004559710.1"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005013701"/>
    <dbReference type="Ensembl" id="ENSMZET00005014169.1">
        <property type="protein sequence ID" value="ENSMZEP00005013701.1"/>
        <property type="gene ID" value="ENSMZEG00005010319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470635"/>
    <dbReference type="KEGG" id="mze:101470635"/>
    <dbReference type="CTD" id="51069"/>
    <dbReference type="GeneTree" id="ENSGT00940000153244"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="39S ribosomal protein L2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="39S ribosomal protein L2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF73">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="11">
        <location>
            <begin position="77"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="10">
        <location>
            <begin position="170"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="298" mass="32770" checksum="B517D29E703A0ACC" modified="2019-02-13" version="1">MALSCLTRALRSLTLSQPALVSSQAAAWSKLGAQVPSSAVIQCRGFLTTASLEQNRVRWKQREKYTIRPIGMKKTGGRDHTGRIRTHGIGGGHKQRYRWVDFHRLRYEANREGQPFEEKVVEVRYDPCRSADIALVAGGERKRWIIATENMQAGDIIKTSGVIGRMAVSANEGDAYPLGALPVGTLVNNLELRPGKGSEYIRAAGTSGVLLRKVNGTAIVQLPSKQQVQVLETCMVTVGRISNVDHNKRIIGKAGRNRWLGIRPSSGLWQRKGGWAGRKIKPLPPMKVYINLPSVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BW60</accession>
    <name>A0A3P9BW60_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein polybromo-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005014240"/>
    <dbReference type="Ensembl" id="ENSMZET00005014716.1">
        <property type="protein sequence ID" value="ENSMZEP00005014240.1"/>
        <property type="gene ID" value="ENSMZEG00005010710.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003017"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05524">
        <property type="entry name" value="Bromo_polybromo_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05517">
        <property type="entry name" value="Bromo_polybromo_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05520">
        <property type="entry name" value="Bromo_polybromo_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05518">
        <property type="entry name" value="Bromo_polybromo_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05515">
        <property type="entry name" value="Bromo_polybromo_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05526">
        <property type="entry name" value="Bromo_polybromo_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21984">
        <property type="entry name" value="HMG-box_PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000009">
        <property type="entry name" value="Protein polybromo-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000011">
        <property type="entry name" value="Protein polybromo-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000013">
        <property type="entry name" value="Protein polybromo-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000006">
        <property type="entry name" value="protein polybromo-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000010">
        <property type="entry name" value="protein polybromo-1 isoform X3"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.30.30.490:FF:000002">
        <property type="entry name" value="protein polybromo-1 isoform X3"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.30.30.490:FF:000003">
        <property type="entry name" value="protein polybromo-1 isoform X3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037968">
        <property type="entry name" value="PBRM1_BD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
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    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="203"/>
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        <location>
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            <begin position="495"/>
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    </feature>
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        <location>
            <begin position="632"/>
            <end position="702"/>
        </location>
    </feature>
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        <location>
            <begin position="912"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="15">
        <location>
            <begin position="1106"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="1326"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="11">
        <location>
            <begin position="1326"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="445"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00069785"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
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        <source>
            <dbReference type="PROSITE" id="PS51038"/>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1547" mass="179249" checksum="E2208AF67CC10C3D" modified="2019-02-13" version="1">MALKRRRATSPSSSVSGGDFDDSQASSLVPSFGRKRRRTSNIPTVDPIAVCHELYNTIRDYKDDQGRMLCELFIRAPKRRNQPDYYHVVSQPIDMMKIQQKLKMEEYDDVEQLTSDFQLLFNNAKTYYKSDSPEYRAACKLWDLYLRTKNEFVQRGEYDEDDEDGYDAQDNPGGSTEDESAPTCLKEVLEQLLDAVVSYTEPTGRLVSELFQKLPSKMQYPDYYAIIKEPIDLKIIAQKIQLGHYRSVNAMAKDIDLLVKNAKTYNEPGSQVFKVRVHLKARYRLLLVFLHKRTFVSDRLSAITMALQYESDEEGILSGSVHYDEGESEAESMTSNMDMSNPIFQLYEAVRGARNSQGQLISEPFLQLPSRKDYPDYYHQISQPICLHQIKNKMKNNEYESVEHIDSDLTLMFENAKRYNVPHSSIYKRALKLQHIQQMKRKELLQRDDDDGDSMLSSATSDTSSTKRKSHKKNTKKNRMKALFAAVNEAREAGTGRRLCDLFMVKPSKKDYPDYYKVILEPMDLRTIEHNIRSDKYLTEDSMLEDMKLMFRNARHYNEEGSQVYNDADVLEKIMKDKRKELGPATDDDDMMSPKLKIRKNSITLKKSKYLTPLQQKLHELYEAVKNYTDKRGRRLSTIFLRLPSRAELPDYYIAIKKPVDMEKIRSHMLANKYQDVDALVEDLVLMFNNACTYNEPESLIYRDALLLHRVLLETRRDLEGGEDAHVPDVPRLIQELIRSLFVSVLGHQDDEGRCYSDSLAEIPAVDPANPEKPSLNFEIIRNNVDRGHYKRLDVFQDHMFEVLEKARRLNRTDSEIFEDAVELQQFFIRIRDELCKNGEILMSPALSYTSKHLHSDVEKEKKEKLPKEFEEDKIKREEEKIEAEKREDPVGGSWQSGLQRTYSQDCSFKDSMYHVGDYVYVEPAEPNLQPHIIYIERLWQDNTGEKWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKAPVSKIMGKCVVMFVKEYFKLHPEGFRAEDVYVCESRYSAKSKSFKKIKMWTMPLSSVRFVPREVPLPVVRVASIFAQKQEEKPPEISRCQQNDLCLQEREDVPLDVTNGEPGCQYYEQLCYNNLWLKVADFVYIASHGLVPHRVGRIEKMWMRDGAGYFFGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCIIGKCVVSSFKDYLSCRPTEVPEENVLLCESRYIESEKQMKKFKGLKRFSLSGKVLEDEIYYFRKLIVPQKEPSPLLDRKIEELEAKFADMTDEELEDLGDDDGELGDQTLPQMQSSMSSDMDIMPYTPPQSTPKSIKGLSKKEGSKRKINMSGYILFSSEMRAVIKAQHPDFSFGELSRLVGTEWRNLDSSRKAEYEGRMGAYRSAMMPLQGHVEGMVSMTGIPPHHMGVPVFPQHLLRVMPGFPGIPYFGKSMGLVGPGQQAPPPYPGQAQMGQPALQQPSTPVFVSPPAKNQRVLHSEAYLRYIEGLTAESSTVSKWDQALSEQESRLPSHWLKSKGAHKTMADALWRLRDLMLRDTLNIRQMHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXH5</accession>
    <name>A0A3P9BXH5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ciliogenesis-associated TTC17-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in primary ciliogenesis by modulating actin polymerization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CATIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXH5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014604"/>
    <dbReference type="Ensembl" id="ENSMZET00005015087.1">
        <property type="protein sequence ID" value="ENSMZEP00005014604.1"/>
        <property type="gene ID" value="ENSMZEG00005010978.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154101"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22973">
        <property type="entry name" value="DD_CATIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048777">
        <property type="entry name" value="CATIP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047501">
        <property type="entry name" value="DD_CATIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505:SF3">
        <property type="entry name" value="CILIOGENESIS-ASSOCIATED TTC17-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21772">
        <property type="entry name" value="CATIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliogenesis-associated TTC17-interacting protein N-terminal" evidence="13">
        <location>
            <begin position="40"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="362" mass="40593" checksum="BC3900DF38C2BC0A" modified="2019-02-13" version="1">MEATLGEQTAVGFSAGTEGPEQYLNLSTLALPSVSLRFSEPAELQKCVFADSLVTVSEGGRELGEFSVTVEFARREQPCMMLHAQSHGAIDDCPCGTAVTAYLTTDLDVLEEDHHEYVKWCPQRVGVKICDPKRDLSECVCVCVQEVTEESMSYPMSVLRGLVTEGSSLLLMRLIALRRKMPENMTFVSLDPGLHIINTSFVSLYACLDQRQLEVGGELLDVFGVERIIQSMEGSPSTWQCYFLDDGHLVTRVQVGSPVTMRLLELPSKGLIETFYTTIPCRPVMCNRRLILDFHYSTDHLKLKADHSSYLRQHPEIRALISDFLQLLLLRKPDDVFLFAREYFTPFASNHPADADQEAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXU6</accession>
    <name>A0A3P9BXU6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentraxin 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561420.1">
        <property type="nucleotide sequence ID" value="XM_004561363.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXU6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014724"/>
    <dbReference type="Ensembl" id="ENSMZET00005015209.1">
        <property type="protein sequence ID" value="ENSMZEP00005014724.1"/>
        <property type="gene ID" value="ENSMZEG00005011083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464059"/>
    <dbReference type="KEGG" id="mze:101464059"/>
    <dbReference type="CTD" id="101887125"/>
    <dbReference type="GeneTree" id="ENSGT01100000263515"/>
    <dbReference type="OrthoDB" id="10009351at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001849">
        <property type="term" value="F:complement component C1q complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042837">
        <property type="entry name" value="PTX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058832">
        <property type="entry name" value="PTX3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46943">
        <property type="entry name" value="PENTRAXIN-RELATED PROTEIN PTX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46943:SF1">
        <property type="entry name" value="PENTRAXIN-RELATED PROTEIN PTX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26206">
        <property type="entry name" value="PTX3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018279124" evidence="2">
        <location>
            <begin position="18"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="3">
        <location>
            <begin position="242"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="457" mass="49972" checksum="A2F9B7DC2DFB78E1" modified="2019-02-13" version="1">MFLRFLRAASLLSMCLCLPSDYEDAIEFNYGPSYYNEIAEEETPAPTPTSAPCRSSELTKWDKMFSMLENSQMRENMLLQYADDIIKVEMGSLRSEMLRFVAQYGGSCGAAVENAGRRMEIQLNSRLRETLELLKLRHRDSPAAAAGNSNQLETMLQELLSAAQTQASRLSKLETSCFSSPGGMNTKAGFHPLRGGEQGHHEQEVTTTEATLEMVLAALQEVKVEMEEALRSSRQRFLPAGCEMALLFPMRSSRIYTSIIPDVPVSLSSFTVCMWFKPTSIANKTVLFTYGNRRNPYEIQLLLKRNAALFTIGGEAHLVEARGVVNPGRWTHLCGAWSSEQGLASLWADGVKVASTPGVAEGHVLPDGGSLQLGQERNGCCPPSLSSGSSVAGFEAGFDSKLAFAGKMTGVNMWDKVLSEDKISQLSLREGHGCEQSGNIVAWGVTEMVPHGGAQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0X9</accession>
    <name>A0A3P9C0X9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004565425.1">
        <property type="nucleotide sequence ID" value="XM_004565368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0X9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015895"/>
    <dbReference type="Ensembl" id="ENSMZET00005016406.1">
        <property type="protein sequence ID" value="ENSMZEP00005015895.1"/>
        <property type="gene ID" value="ENSMZEG00005011930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468255"/>
    <dbReference type="KEGG" id="mze:101468255"/>
    <dbReference type="CTD" id="8893"/>
    <dbReference type="GeneTree" id="ENSGT00510000047568"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000033">
        <property type="entry name" value="Eukaryotic translation initiation factor 2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000022">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000100">
        <property type="entry name" value="translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="529"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="708" mass="80175" checksum="33E926202FBBD5FB" modified="2019-02-13" version="1">MASKGGKQSRSASGLSCRKGAGDQEEEEQPLQAVLVADSFNRRFFPVTKDQPRALLPLGNVAMIDYTLEFLTSTGVQETFVFCCWMASKIKAHLQKSKWCRPSSPNTVHIITSDLYRSLGDVLRDVDAKSLVRSDFILVYGDVVSNIDISQALQEHRHRRKMDKNISVMTMIFKESSPGHRSRCEEDDVIVAVDSKSQQILHYQKTQGLKKLQFPMNIFHSGSEEFEIRHDLLDSHISICSPQVAELFTDNFDYQTRDDFVRGLLVNEEILGNQIHVHVTQDGYGVRVSNLLMYDSVSSDLVRRWVYPLTPEANFTDQEGHSCTYSRHNVYRASGVSLGHGSQMEENVLIGCDTSIGANCYISNSVIGDNCIIGDNVVLDHAYIWNHVHIASNVEIIQSVICNKAEVKEGVTLKKQCVLAYDVVIGPNISLPEGTVVSMHHPEEEEEDDDEFLSDDAEVGQRSDKTKQKVFNPAEVGAEGKGYIWKASSLDDTEEEELSQCLWGLVLNPDPESDSEDSDTDDPDDPVIPSPEMDDVKVFHMEVLGTLQRGLEENISCDNLVLEINSLKYAYNISLKEVMQILTRVVLEYPFQQQGTHLTPSQYVTLLLPLLKKWAPVFKNYVKRAQDHLDCLSAFEEHFLEQESHWAAMVKVLMNMYELEILEEEMILRWFSQGATSDKSRQLRKNQGLQKFIQWLEEAEESSEEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C193</accession>
    <name>A0A3P9C193_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C193"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015646"/>
    <dbReference type="Ensembl" id="ENSMZET00005016149.1">
        <property type="protein sequence ID" value="ENSMZEP00005015646.1"/>
        <property type="gene ID" value="ENSMZEG00005011738.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155493"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF41">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018221845" description="Transmembrane 9 superfamily member" evidence="8">
        <location>
            <begin position="45"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="605" mass="69833" checksum="8432B62AE8A93400" modified="2019-02-13" version="1">MRLLRHMRTRASLKIASVIQPGRRWKVVAAVVFALVCSLSPVDADEHDHTYTDKEEVVLWMNTVGPYHNRQETYKYFSLPFCAGSQKTISHYHETLGEALQGVELEFSGLQIKFKEEVMQSTYCEIELDKAKRDAFVYAIKNHYWYQMYIDDLPIWGIVGEADENGEEHYLWTYKKLEIGFNGNRIVDVNLTSEGKVRLVPNTRIPMSYSVKWKKSDVKFEDRFDKYLDPSFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKEEEMDDMDRDLGDEYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFSVSLIVIIVAMVEDLYTERGSMLSTAIFVYAATSPVNGYFGGSLYAKQGGRRWIKQMFIGAFMIPAMVCGTAFFINFIAIYYHASRAIPFGTMVAVCCICFFVILPLNLVGTILGRNLSGQPNFPCRVNAVPRPIPEKKWFMEPAVIVCLGGILPFGSIFIEMYFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFLLNAEDYRWQWTSFLSAASTAVYVYMYSFYYYFFKTKMYGLFQTSFYFGYMAVFSTALGIMCGAVGYMGTSAFVRKIYTNVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2L8</accession>
    <name>A0A3P9C2L8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Si:dkey-122a22.2</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2L8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016505"/>
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        <property type="gene ID" value="ENSMZEG00005012373.1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="397" mass="44763" checksum="A494A1315DE6A562" modified="2019-02-13" version="1">MNQFLSAFHYFVQREEEPNPLNKTALFTALFVCLRLTYGLSNEYFTFKRIIGKRPSQAEVKGSVSYSSVLVNIGKCLLVIILVPPFLNYASLQREAQMLLPKDGQIVDVGLGQKMHLLCKGRGKPVGNKLPAGLDCSVCTYDRMGLGFSKRLMQNETTGTEKVWDMSTTGRMVDDLHRLLGAAEIVGPFILVGSELGALNSRFYTHIHDVQVSDLVLIDPIPEDIFEEDKWKEYWYGKVVPSFQAKQFSAATGLSRMLIILGAIEPTVKGENVSEEVIQRQKYLQSNPAHQSAAVDEHYFLNESAAQVRDITKFKPLSSRTSVSVLTGDSFDMQMPEHLNRVSAFTLQKRFLEDSYPSANHIHIKGADRRMIYKKPSAISQHLRKLVNQRQAKQQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4F5</accession>
    <name>A0A3P9C4F5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ileal sodium/bile acid cotransporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Apical sodium-dependent bile acid transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Ileal Na(+)/bile acid cotransporter</fullName>
        </alternativeName>
        <alternativeName>
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        </alternativeName>
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            <fullName evidence="19">Na(+)-dependent ileal bile acid transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 10 member 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="32 33">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
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            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71911"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29747"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71935"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29746"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>tauro-beta-muricholate(out) + 2 Na(+)(out) = tauro-beta-muricholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72179"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:133064"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tauroallocholate(out) + 2 Na(+)(out) = tauroallocholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:51840"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:191406"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>taurochenodeoxycholate(out) + 2 Na(+)(out) = taurochenodeoxycholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71923"/>
            <dbReference type="ChEBI" id="CHEBI:9407"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>taurocholate(out) + 2 Na(+)(out) = taurocholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71875"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:36257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>taurodeoxycholate(out) + 2 Na(+)(out) = taurodeoxycholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72087"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:36261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>tauronorcholate(out) + 2 Na(+)(out) = tauronorcholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71915"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:191405"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>tauroursodeoxycholate(out) + 2 Na(+)(out) = tauroursodeoxycholate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71927"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:132028"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4F5"/>
    <dbReference type="Ensembl" id="ENSMZET00005017709.1">
        <property type="protein sequence ID" value="ENSMZEP00005017163.1"/>
        <property type="gene ID" value="ENSMZEG00005012894.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182808"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008508">
        <property type="term" value="F:bile acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000010">
        <property type="entry name" value="Solute carrier family 10 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00841">
        <property type="entry name" value="bass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF19">
        <property type="entry name" value="ILEAL SODIUM_BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0915">Sodium</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="7 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 31" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00046038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="319" mass="34322" checksum="265FBF0221DFD05E" modified="2019-02-13" version="1">MSTLKPTTMLPAICDNAATACSGTDCLVPPSNFNAILGVVMSTVLTIMLAMVMFAMGCTPWGIIIGFLCQFGIMPFTAFALSLAFGVQAVQAVVIIIMGCCPGGSNSNIICYWLDGDMDLSLSMTACSSLLALGMMPLCLLIYTSVWTSSDTIKIPYDSIGITLAALIIPIGVGMYVKHRWPEMAKKILKVGSIVGLVLIIIIAVIGGVLYQSSWTIAPSLWIIGTIYPFIGLSLGFFLARFVGQPWYRCRTIALETGIQNAQLCSTIVQLSFTPEELEKMFAFPLIYSIFQLVSALIFVGGKTLKQTTHTLAIFSCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6M6</accession>
    <name>A0A3P9C6M6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P2Y purinoceptor 14-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C6M6"/>
    <dbReference type="Ensembl" id="ENSMZET00005018507.1">
        <property type="protein sequence ID" value="ENSMZEP00005017923.1"/>
        <property type="gene ID" value="ENSMZEG00005013478.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01110000267167"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045028">
        <property type="term" value="F:G protein-coupled purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14982">
        <property type="entry name" value="7tmA_purinoceptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24233:SF11">
        <property type="entry name" value="P2Y PURINOCEPTOR 14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24233">
        <property type="entry name" value="P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="40"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="336" mass="38261" checksum="A36F690FED53EC24" modified="2019-02-13" version="1">MADSTNGTSSFNQTCDPVVPSLNPFFVLVYSLVFLVGLLHNGFILKFYIGQAQQQESNSLMVYLKNLTAADFLLCLSLPLRIAHYDRKSFIIQKVYCSFGASAFYMNMYASIIFIYLLSPLSSLFRYLKIVHPSGTHVLQSVRTAHIISMVTWVCLLAPSVTYSILFFITQKPLTFTPSQCWPLFSASISLFFKILHTICAIIFLLVFISLVFFYHGISRRVLQAQQRQLASSNAEKLVKSRRNMLVLVSIFCVCFVPYNLVRLPVTFLWTSCSAGRLLFYLEEVATMVSVFNICLDPLVYFFLCKSFWDQMSQTNTESQSTEEKLSIIKSSKSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7H7</accession>
    <name>A0A3P9C7H7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Collagenase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Matrix metalloproteinase-13</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="21">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004543978.2">
        <property type="nucleotide sequence ID" value="XM_004543921.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7H7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018052"/>
    <dbReference type="Ensembl" id="ENSMZET00005018640.1">
        <property type="protein sequence ID" value="ENSMZEP00005018052.1"/>
        <property type="gene ID" value="ENSMZEG00005013568.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101486079"/>
    <dbReference type="CTD" id="100329766"/>
    <dbReference type="GeneTree" id="ENSGT00940000160903"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000007">
        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000002">
        <property type="entry name" value="Matrix metallopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF165">
        <property type="entry name" value="COLLAGENASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0177">Collagen degradation</keyword>
    <keyword evidence="16 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 24" id="KW-0732">Signal</keyword>
    <keyword evidence="11 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017949988" description="Collagenase 3" evidence="24">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="25">
        <location>
            <begin position="109"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="23">
        <location>
            <begin position="334"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="23">
        <location>
            <begin position="381"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="21">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="282"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="473" mass="54558" checksum="E50891A6BE60F267" modified="2019-02-13" version="1">MGLLWIPVLGSLMLVEILWTLPIDKDQQRLEDVELAEDYLKRFYSLNLGDHRPPVRSVRSASTMEEKIQEMQNFFGLKETGNMDPHTLNVMKEARCGVPDVDNFAFYPNRPKWKNHIITYTIARYTPDMKKEDVEKSVRSALKMWSDATPLKFIKINHRKADIVFSFSRRTHGDFFPFDGPGGVLAHAFMPGMGMGGDVHFDEDETWTAGTQGYSLLSVAAHELGHSLGLTHSRDPSAIMYPNYRHQSNAKYSLSNDDVRGIQTLYGRPNKKMETQVASKKCDPTFPQLFDAVTLIENEICFFKNRHMWMRTTRTTYWNRLTQGHITTYLPSISSQIDAAYDIPAKGVAYIFTGHKYWVVEQLKMKSRAGSIYEYGFSSRVRRVDAAVHVSEYGKTMFFVGEFYYRYDEHNRRMDPGFPRLIRNDWSGVPRRVDAAFKLQGSIFLLCGTKSYQYDFRQKQVVNVIPGKSWLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7X7</accession>
    <name>A0A3P9C7X7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004569074.1">
        <property type="nucleotide sequence ID" value="XM_004569017.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7X7"/>
    <dbReference type="Ensembl" id="ENSMZET00005018604.1">
        <property type="protein sequence ID" value="ENSMZEP00005018016.1"/>
        <property type="gene ID" value="ENSMZEG00005013535.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468855"/>
    <dbReference type="KEGG" id="mze:101468855"/>
    <dbReference type="CTD" id="798421"/>
    <dbReference type="GeneTree" id="ENSGT00950000183060"/>
    <dbReference type="OrthoDB" id="187568at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07912">
        <property type="entry name" value="Tweety_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF4">
        <property type="entry name" value="PROTEIN TWEETY HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="492"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="554" mass="61335" checksum="22280E412B637F5F" modified="2019-02-13" version="1">MAAVVNYSPPWWVNLLHRLPHFNIEFQTVSSDFRPEDSEYQKSVLLLGAVALLCLGLDLIFLLFYSFWLCCRRRKSDESSHSHMHSQQPSADCCCTAWCVIIATLVCSAGIAVGFYGNGESSDGATRLAYSFRHANRTVSGVEKLVSDSALALNQTVEENLVQLETAFQDQTDYVSIVQKLQGQLDELVRLMVDVPFWSNTEISLEDLARKTEAFDFYRWLGYLGLLLFDVLICLLVLFGLIRNSRGTLIGVCLLGVLTLIISWGSLGLELAVAASASDFCVSPDTYITRVTKENDVINQDILQYYLTCSSGQINPFQQRLSGSHKALVEMQDDVAELLRSAARDFASTKGNLEQIQSVLNSTEVGLHQLTALVDCRSLHMDYVQALTGLCYDGVEGLIYLVLFSFVTALMFSSIVCSVPHTWPGKRMDEEDGEDESGASRGGVHDNLYRVHMPSLYSCGSSYGSEASLPATAHTVSNAPVTEYMSQNANFQNPRCENTPLIGRESPPPSYTSSMRAKYLATNRPDQNRRSVPNDQLDPASRPHPAARPQSSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8D7</accession>
    <name>A0A3P9C8D7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Procollagen C-endopeptidase enhancer a</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557386.2">
        <property type="nucleotide sequence ID" value="XM_004557329.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8D7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018342"/>
    <dbReference type="Ensembl" id="ENSMZET00005018934.1">
        <property type="protein sequence ID" value="ENSMZEP00005018342.1"/>
        <property type="gene ID" value="ENSMZEG00005013775.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101474320"/>
    <dbReference type="CTD" id="563867"/>
    <dbReference type="GeneTree" id="ENSGT00940000159264"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03576">
        <property type="entry name" value="NTR_PCOLCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035814">
        <property type="entry name" value="NTR_PCOLCE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF48">
        <property type="entry name" value="PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018195892" evidence="9">
        <location>
            <begin position="24"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="10">
        <location>
            <begin position="157"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="11">
        <location>
            <begin position="347"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="281"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="466" mass="51417" checksum="17D05C98FA9AE110" modified="2019-02-13" version="1">MKPMSHIWGLSLVLSLSLGWTKAQQTNFTRPVFYCGGDMVAESGFVGSEGFPSFYKPNSKCAWRITVPEGNVITLSFRIFDLEADSQCRYDYLDVYNGHSNLVQKLGRFCGTFRPGALISTTNMMMLEMVTDDETQSRGFLAYFSAVKPYVSDEQFCGGRMTKAQGEIKTPNWPDKKYEPGTSCSWLITVEPNMVIHVNFDKFALEDDTYCRFDYVAFFNGGERDDSRLIGKYCGDQVPEPIVTSGNVLLVQFVSDLSVTSDGFLAHFTSIARGSQIPTVNSGQTTRYSPPVPSVKPAHPSTPIETTTKYVPAPVPRSTPSPKPVKPTRDRNAKPNGKRPVPQNPLCAKACKRNGTIKTSLCASEFVLTGKVTSVAPRPRGAIQITVSLIKAYKAGRLTITQVGETMSVKLMSQCKKCPLFRKGVNYIIMGQVNEQGQGTLEPGAFTALYKAPHHKLLMNISQQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8G0</accession>
    <name>A0A3P9C8G0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="10">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Directly interacts with POMP. Interacts with ABCB1 and TAP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004565403.2">
        <property type="nucleotide sequence ID" value="XM_004565346.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8G0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018565"/>
    <dbReference type="Ensembl" id="ENSMZET00005019165.1">
        <property type="protein sequence ID" value="ENSMZEP00005018565.1"/>
        <property type="gene ID" value="ENSMZEG00005013801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485859"/>
    <dbReference type="KEGG" id="mze:101485859"/>
    <dbReference type="CTD" id="5693"/>
    <dbReference type="GeneTree" id="ENSGT00940000157841"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000030">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF11">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="281" mass="30615" checksum="69D06CDE3EBB54E5" modified="2019-02-13" version="1">MLLVHHTFSKMALASVLSGDSADFSFDSSQSFAFGGGPGPRGLGLEGTPEDSLSFSVKNPLCVGDDDGVERKIEFLHGTTTLAFKFQHGVIVAVDSRATAGSYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMVCGWDKRGPGLYYVDSEGNRVCGDLFAVGSGSMYAYGVMDSGVRHDLTVEEACELGRRAIYQATYRDAYSGGQVNLYHVHSEGWTRISQDDVLVLHHQYKDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9G7</accession>
    <name>A0A3P9C9G7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dynein cytoplasmic 2 heavy chain 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9G7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018742"/>
    <dbReference type="Ensembl" id="ENSMZET00005019344.1">
        <property type="protein sequence ID" value="ENSMZEP00005018742.1"/>
        <property type="gene ID" value="ENSMZEG00005014054.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154620"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000006">
        <property type="entry name" value="cytoplasmic dynein 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000006">
        <property type="entry name" value="Dynein cytoplasmic 2 heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF22">
        <property type="entry name" value="DYNEIN CYTOPLASMIC 2 HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="2">
        <location>
            <begin position="108"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="3">
        <location>
            <begin position="262"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57616" checksum="1A33955D81709AEB" modified="2019-02-13" version="1">MGQGQADVALATLRECSRNGDWLCLKNLHLVTAWLPLLEKELNVLRPKAGFRLWLTAEVHPRFPPILLQSSLKITYEDPPGLKKNLLRTYESWTPEQISKGGILARAQSLFCLGWFHAVCQERRNYIPQGWTKFYEFSLSDLRAGFEIIDRLFEGGKQFQWEFVHGLLENAIYGGRIDNPSDLRILRSYLEQFFSARLLSSSHSAGQRKSRGGFFPPQISLPNSCAILDYRRVIENLPEDDRPAFFGLPANIARSSQRIVSSQVISQLRILSRSVATGSKFDRELWSNGLSPILNLWKKLNQGSTLIHQKVDPPTESQKSPVLSFISLEQFNAIRLVQSIHQSLAALSKVIRGTQLLTPEVQKLATALLNQECPLTWQNKWEGPEEPMQYLRAVVTRALAIQSWVEHANRQALLSDILDLSELFHPDTFLNALRQETARTMSCSMDSLVFVSSWRSPIAQAKLQVKIGGLQLEGCSFDGVHLCENQHDSPSVSAVPTCYMAWVPQVCMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9Y6</accession>
    <name>A0A3P9C9Y6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9Y6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019098"/>
    <dbReference type="Ensembl" id="ENSMZET00005019712.1">
        <property type="protein sequence ID" value="ENSMZEP00005019098.1"/>
        <property type="gene ID" value="ENSMZEG00005014326.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244838"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF145">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="268" mass="31646" checksum="0879F9D7AB892BFE" modified="2019-02-13" version="1">QDFQALTVWQKVQLFYHGILEKGDKRTDNWLLVYSPVPISCVFLCYLIIIWVGSKLMARRQPVNLRPVLIVYNFAMVCLSAYMFYEFTTSSWLAGYSLLCQPVDYSDSPLAMRMARVCWWFYFSKVIELCDTIFFILRKKNSQLTFLHVYHHATMIFNWWAGVKYVAGGQSFLIGLINSLVHIVMYMYYGLAAVGPSMTKYLWWKRYLTTLQLLQFFIVTIHTSYNLFADCDFPDYMNITVLAYSLSLIILFSNFYYRSYLVKKNKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAF7</accession>
    <name>A0A3P9CAF7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calmodulin regulated spectrin-associated protein 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The CKK domain binds microtubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CAMSAP1 family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005018886"/>
    <dbReference type="Ensembl" id="ENSMZET00005019492.1">
        <property type="protein sequence ID" value="ENSMZEP00005018886.1"/>
        <property type="gene ID" value="ENSMZEG00005014145.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182975"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036449">
        <property type="term" value="C:microtubule minus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000070">
        <property type="entry name" value="Calmodulin regulated spectrin-associated protein 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.360:FF:000001">
        <property type="entry name" value="Calmodulin-regulated spectrin-associated protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.360">
        <property type="entry name" value="CKK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031372">
        <property type="entry name" value="CAMSAP_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058042">
        <property type="entry name" value="CAMSAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038209">
        <property type="entry name" value="CKK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF3">
        <property type="entry name" value="CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17095">
        <property type="entry name" value="CAMSAP_CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08683">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25532">
        <property type="entry name" value="CH_CAMSAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="215"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CKK" evidence="10">
        <location>
            <begin position="1408"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="882"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1240"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="830"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1167"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1187"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1198"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1241"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1307"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1327"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1545" mass="171648" checksum="48C0F30C85BB4A29" modified="2019-02-13" version="1">IERQFGRATARTVELAGVAEGTMDVVPLEMYDSARAKIAANLRWLFAKAYGIDHIPEDLRDPFYTDQYDQEHIKPPVIRLLLSCELYCRVCALILKTEQAVSLQSHMSVIQALSRKGIYVVESDDTPVTEGDLACMPIKMSAHMPMIDALMMAYTVEMISIEKVVASVKRFSTFSASKELPFDLEDAMVFWINKVNMKMREIAEREHKVKHHPLESPSHQKVRYRREHASGRQLPFFPLLEDLMRDVCDGAALLTVVHYYCSDLMKLEDICLKEVPSIADSLYNIQLLREFANEYLNKSFYLTTEDMLYSPPVLKHNVMVFIAELFWWFETVKPEFVQPRDLQEFKDRKYYTIAHPKSARPSVPISNATKRSFLASPGMADNQSSPEVCNRYFLHPEDSDPLKGGPTFSPSHPLLPLRQRQQKQQGDDDYLYCAYSTDFTAEVILMISFCRPVSTMGPYLLHSATDSDADIASGDSVSLARSISKDSLASNVINVTPKHQTSVHQPSRPPVRRVNGHSLLTNVNTEDEEETLVTVAKSDGPAISKRVEGTQSAAVIGSKPSTDSKLTPDSFYLEPLMPAVLKTAKEKSVCLNKEEESGEVSRSAGRGSLRRENGSTSAVRRKAPSNLNQTFPPPAEEGLSDEPVQSQASLRLSSSVEPSSRDPAEGFYLHSDSEELKPGNGQDGDLGDLDEEEEDLDEAATTKETLWPRKAFNEEEEESAKLQEDMNVKEHEDKDINGGSGRSSPCLSTHSQASSMASGSVRMTSFAERKAQQQRFGSNHDLRSSASSSQRTTPDGSECSGPLASSWRIKRDQSPSSPLGGSSRTGSGGANVLASELVQLRMQLEEKRRAIEHQKKKMEVLSARQRQKLGKAAFLHIVKKGGGRSDTLPNPLKADISKDELNGEKGPSSKDDMCVDTMRGEKEVDETTPSGALEAEKKGNGGSFYLDEDLDLNECSRSIELLNEAIGSIQQQMMQLSLQQEMLMKQNVQSPPGAAPPPAQTSDKNGDSKTGAGFHFVEHLSGTSTAPTRKPPKLSSGRSARSKPSELKMAKEQSRQTTRTLTPTQSGSETLPHPKHSAGGRSPRTEQPDSPRNPTVVETVDKPGSGHVRSATFRLHDEANIRLPTRVDLTSLAPPEVPFDECLSSNTRESELNSSDGSGKENIPSDEAQRNKTHLIEVDLSELKAPEEEEEEEEEGGVEDKTTERDDGEQKSVLGFFFKDEQKAEDELAKKRAAFLLKQQKKAEEARLRKQQLEAESELKRDEARRKAEEDRLRKEEEKTRRELIKQEYLRRKQQEMFEEQGLVKPKTPKPKQKHRPKSVLREESSSDNFSKCSSTADKLSNAQSGSNLSLASAATNEADSVNSGGAGSQRCDSVESFPGSRNSRAAERDWDNGSTASSITSMAEYTGPKLFKEPSAKSNKPIIHNAISHCCLAGKVNEPQKNQILEELEKCESNHLMILFRDGGCQFRALYSYFPDTEEIQKLTGTGPKSISKKMIDKLYKYSSDRKQFTVIPAKTVSVSVDALTIHNHLWQAKRSAVPKKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CC41</accession>
    <name>A0A3P9CC41_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Twinfilin actin binding protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012773968.1">
        <property type="nucleotide sequence ID" value="XM_012918514.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CC41"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019584"/>
    <dbReference type="Ensembl" id="ENSMZET00005020213.1">
        <property type="protein sequence ID" value="ENSMZEP00005019584.1"/>
        <property type="gene ID" value="ENSMZEG00005014694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105940869"/>
    <dbReference type="KEGG" id="mze:105940869"/>
    <dbReference type="CTD" id="11344"/>
    <dbReference type="GeneTree" id="ENSGT00530000063868"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000012">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF9">
        <property type="entry name" value="TWINFILIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="180"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="352" mass="40642" checksum="FE9605F36402080E" modified="2019-02-13" version="1">MFLALVVTPELRQFLARARGGTVRLIKVRIQDEQLVLGAYREPEKSWDQDYDRFLLPLLDDQEPCYILYRLDSQNALGYEWVFISWSPDQSPVKQKMLYAATRATVKKEFGGGHIKYELFGTTEEDICLLGYQHHVSSCSAPAPLTLAEQELQRIKITEGRVKQVTTEISVESKHQTLQGLAFPLQDAAKRALQQLAQKRINYVQLRLDVEKETIELVHSNPTETRDLPCRVPRDTPRYHFFLYKHSHEGDYLESVVFIYSMPGYSCSIKERMLYSSCKSRLLEEVEKDYHLEIAKKLEIDDGDELTADFLYDEVHPKQHTHKQAFAKPRGPAGKRGHKRLIKGTEEAVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CC48</accession>
    <name>A0A3P9CC48_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lysosomal enzyme trafficking factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 251</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LYSET family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CC48"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019870"/>
    <dbReference type="Ensembl" id="ENSMZET00005020514.1">
        <property type="protein sequence ID" value="ENSMZEP00005019870.1"/>
        <property type="gene ID" value="ENSMZEG00005014923.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007473"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028024">
        <property type="entry name" value="LYSET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31925:SF1">
        <property type="entry name" value="LYSOSOMAL ENZYME TRAFFICKING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31925">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15190">
        <property type="entry name" value="TMEM251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="114" mass="12964" checksum="EB9E86724C70CFD4" modified="2019-02-13" version="1">MMNFRQRMGWVGVAFYLLLSVMAAYYIFEVHSFSLERVQRAGTSPSAPPPAITVHGSLLPVWMWALIFLLPYLQLFLFLFSCTRADPRAVGYCVLPVCIALLYSRRHAAKLANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCW1</accession>
    <name>A0A3P9CCW1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AZ1 forms a heterodimer with H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004576020.1">
        <property type="nucleotide sequence ID" value="XM_004575963.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CCW1"/>
    <dbReference type="SMR" id="A0A3P9CCW1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020118"/>
    <dbReference type="Ensembl" id="ENSMZET00005020765.1">
        <property type="protein sequence ID" value="ENSMZEP00005020118.1"/>
        <property type="gene ID" value="ENSMZEG00005015094.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475850"/>
    <dbReference type="KEGG" id="mze:101475850"/>
    <dbReference type="GeneTree" id="ENSGT00900000140979"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="128" mass="13597" checksum="36EA88817EE2CA40" modified="2019-02-13" version="1">MAGGKAGKDSGKTKTKAISRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDL1</accession>
    <name>A0A3P9CDL1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Slit homolog 2 protein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDL1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020380"/>
    <dbReference type="Ensembl" id="ENSMZET00005021032.1">
        <property type="protein sequence ID" value="ENSMZEP00005020380.1"/>
        <property type="gene ID" value="ENSMZEG00005015281.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166908"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031102">
        <property type="term" value="P:neuron projection regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051071">
        <property type="entry name" value="LRR-bact_E3_ubiq_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47114">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47114:SF3">
        <property type="entry name" value="LEUCINE-RICH ALPHA-2-GLYCOPROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018129508" evidence="6">
        <location>
            <begin position="27"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="7">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="459" mass="50265" checksum="977B17D676F356EE" modified="2019-02-13" version="1">MSICLELSATCGVLLALCICPLACLAVSPCPTGCCCPGFLVLCESLGLRSLPRLVPLSTSALSVARNQLCNVDHQLWPFSGLQELSLSHNLLARFPRGLPPSLESLQLQENRITYITSGVLRQLGNLTHLDLEDNRIRAIQPGALQGLHKLQVLMLKGNRLTSLPMSLPPSLTHLDLSENCISALDLPSLSALVNLQVLKINSNCLRSVPESAFDSLPRLRSVDLTNNLWVCECDILYLYRWLLSGRLKMATDIVCTEPDHLAHRLLLNLSVVAICPRVLKPNDRTHERDLSSAQARMLTAQPAEKISKLTTNGLLSEALNSNQDSSKTRVLHYSLETLTYEECLSLNNSQSVSPFHLKTTTSLPEEEQRCRDNITARYPQSNVTLAEGTQFLLSTHRDALVPTLVPQLFTQQASAAIVSLLVVLCVLVALVMLAVLLVLKKVLVRQQRVAPADSGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDV5</accession>
    <name>A0A3P9CDV5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized LOC101470953</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDV5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020430"/>
    <dbReference type="Ensembl" id="ENSMZET00005021086.1">
        <property type="protein sequence ID" value="ENSMZEP00005020430.1"/>
        <property type="gene ID" value="ENSMZEG00005015323.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155751"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="486" mass="54168" checksum="CEA4D0C331ED7C24" modified="2019-02-13" version="1">MEEPAVQQEKIEGSWEGGHDEGKADWKNECSLSSLLKHSCLLCWSSPRDADIMETDERILAKTAEIRELESAVAVENLELQEQRSDRKELEETLVKLEKHKEKLIQQIKGTRQLCYEESQQILSLQAEEAQKESQVEEYERELSRARWRLRKLREEVKQAKRKVEEAGERNSPLQDSIRQSYEEILQEEHTLYSLSGGAVTPESHLDESTSLADTTEDNLPSLRPWGRSQSLPAYADLIMGGSGSPFCNNLVGTREEDDSGTSSPKMDRSDIEDGLEEGDLNAEGENERDQEEFTMNPNPLSQLDFYQANPFARYDLFNEDLFLKTDSSDGFGSDPFKGSDPFAADILFPLTNTATGESTGNAGDEADTSLSCVENKASTGTQCFESEFPDEDSDIEISYSREDLDTIAMEDDSHGFKPIQSSSEELGPEPIRGWRSQGQYSVESDPNGYELDLGAVSPPSDIEEHSLVSLAGEAITQSSAGLEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDZ5</accession>
    <name>A0A3P9CDZ5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-processing factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PRP6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">U5 snRNP-associated 102 kDa protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDZ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020362"/>
    <dbReference type="Ensembl" id="ENSMZET00005021014.1">
        <property type="protein sequence ID" value="ENSMZEP00005020362.1"/>
        <property type="gene ID" value="ENSMZEG00005015261.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075016"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000054">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000058">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:003529">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="13" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="16">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="938" mass="106266" checksum="E1BF50AA61FF21D7" modified="2019-02-13" version="1">MPLASPLMGKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKNQDDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERRELREKEEIEKYRMERPKIQQQFSDLKRKLAEVSEEEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFSKHLQSGENHTSVDPLQGLGGLNTPYPGSMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTYGGDISDIKKARLLLKSVRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKAVVAQAVRHLPQSVRIYIRAAELETDVRAKKRVLRKALENVSKSVRLWKTAVELEEPEDARIMLSRAVECCPTSVELWLALARLETYENARRVLNKARENIPTDRHIWITAAKLEEANGNTQMVEKIIDRAITSLRANGVEINREQWIQDAEECDKASSVATCQAVIRAVIGIGIEEEDRKHTWMEDAESCVAHGALECARAIYAHALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRAVAHCPKAEVLWLMGAKSKWLAEDVPAARSILALAFQANPNSEEIWLAAVKLESENNEYERARRLLAKARSSAPTARVFMKSVKLEWVLGNIEAAQELCTEALKHYEDFPKLWMMRGQIEEQCENMDKAREAYNQGLKKCPHSVPLWLLLSHLEERVGQLTRARAILEKARLKNPQTAELWLESVRLEYRAGLKNIANTLMAKALQECPNSGVYPVAEAVFLEARPQRKTKSVDALKKCEHDPHVLLAVAKLFWSERKITKSREWFLRTVKIEPDLGDAWAFFYKFELQHGTEEQQEEVRKRCENAEPHHGELWCAESKHVLNWQKKTGEILAQVASKIKNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEF0</accession>
    <name>A0A3P9CEF0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transmembrane protein 106B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TMEM106B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the TMEM106 family.</text>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="87"/>
            <end position="108"/>
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        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
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        <location>
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            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
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        </location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3P9CEH5_9CICH</name>
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        <name type="common">zebra mbuna</name>
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            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEH5"/>
    <dbReference type="Ensembl" id="ENSMZET00005021335.1">
        <property type="protein sequence ID" value="ENSMZEP00005020655.1"/>
        <property type="gene ID" value="ENSMZEG00005015497.1"/>
    </dbReference>
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        <property type="component" value="LG23"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="FNDC_type_III_4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14470">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14470:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="201" mass="22492" checksum="6EDF1E513610B3DA" modified="2019-02-13" version="1">YLKKEPINELQVMLVCLHISVPAPPVNVSVTQLRAHSAMVTWNVPQGDTVIGYAISQQRQDGLMQRSIREVNTSSRWCVLWDLDEDTHYSVQVQSVGPHGDSPPSRAVHFRTLERTDHYPAGPAMEGLGMTPQLETGELLIITTVLLLWAAVIALFCRQYDIIKDNDSNGTKEKAKRPLVRATSSYYNLHRASSSISIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF38</accession>
    <name>A0A3P9CF38_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SH3-domain binding protein 4a</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CF38"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020903"/>
    <dbReference type="Ensembl" id="ENSMZET00005021589.1">
        <property type="protein sequence ID" value="ENSMZEP00005020903.1"/>
        <property type="gene ID" value="ENSMZEG00005015690.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013151"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000008">
        <property type="entry name" value="SH3 domain-binding protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056183">
        <property type="entry name" value="DEATH_SH3BP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056181">
        <property type="entry name" value="SH3BP4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056182">
        <property type="entry name" value="UPA_SH3BP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15603:SF3">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15603">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24094">
        <property type="entry name" value="DEATH_SH3BP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23637">
        <property type="entry name" value="SH3BP4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23640">
        <property type="entry name" value="UPA_SH3BP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="13">
        <location>
            <begin position="275"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="613"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="919" mass="102888" checksum="01795871DB63EAC0" modified="2019-02-13" version="1">MAAHRIIRVTNNNHILPRCKSEGTLIDLSEGVSGASLSDVKVPSPSALRLDTSASYGAAQEVVAIKDYCPSSFTTLKFSKGDRLYVLDTSGGEWWYAHNNTEMGYIPAAYVQPVSFRNSSLSDSGMIDSAGEGYEDGLKESGGLGEWTAVSLRPSPIYNNSHFSANPFICPLDQNCKEADVRHSITPNLHRDNPFFRSKRSHSLSELSVLQAQSNATLPSSGFFTGLKAPSPEQFQSREDFRTAWLNHRKLARSCHDLDSLGQSPGWGQTQPVETNIVCRLDCNGGVVQLPDTHISVHIPEGHVSHGDHQQISLKALLDPPLELNNDHCSTISPVVELKLSNMETKSFITLEMKVSVTVKRESCHTAEVVCVRSDFKEGPYTPIPNAYIYKDTVQVQLDSLEPCIYVAVVVQSQYLSHNTTVWDHVQKKVTLGVYGPKHIHPSFKTVVAMFGHDCAPKTLLVNEVGRQSSSTPPAALQLWGKHQFVLGYPQDLKVGLYSNMSNYQVKASEGAGMIRGFQVKLGKVSRLLYMITSHNPSSISDFTLRVQVKDALDCILTQFCVQTPQPPPKTGARITGQRRFLKKKEVDKIVLSPLAVTSKYPKFQERCITNLKFGKLIKTVIRQHKSTYLLEYKKGDVIALLSEEKIKLRGQLRTKEWYIGYYQGKVGLVHAKNVLVLGKVKPIYWCGPDLTTTMLLEQILKPCKFLTYIYATVRTVLMENVGSWGAFVDALGYGNLPLNYFCRTELDNEPEKVASVLEKLKEECTNMENKERKSFQRELMMALLKMDCQGLVARLVLDFVLLTTAVEVASRWRELAEKLARVSKQQMEAYEAPHRDKNGLLDNESMWKPAYDFLLTWAAHVGDSYRDVIQELHLGLDKMRNPITKRWKHLTGTLILVNCLDTLRSAAFCPTGYGDFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF99</accession>
    <name>A0A3P9CF99_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Collagen, type V, alpha 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CF99"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020536"/>
    <dbReference type="Ensembl" id="ENSMZET00005021202.1">
        <property type="protein sequence ID" value="ENSMZEP00005020536.1"/>
        <property type="gene ID" value="ENSMZEG00005015382.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000168325"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000001">
        <property type="entry name" value="Collagen alpha-1 type I chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COLLAGEN ALPHA"/>
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    <dbReference type="PANTHER" id="PTHR24023:SF958">
        <property type="entry name" value="COLLAGEN ALPHA-1(I) CHAIN"/>
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        <property type="entry name" value="NC1_FIB"/>
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            <dbReference type="ARBA" id="ARBA00023278"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50184"/>
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            <dbReference type="PROSITE" id="PS51461"/>
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            <dbReference type="Ensembl" id="ENSMZEP00005020536.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="1168" mass="116055" checksum="73445904680EE11F" modified="2019-02-13" version="1">KCVFSNEKKEENCKVNGEVYHHNDIWKPEPCRVCVCDNGVTVCDEIQCEVLSNCEKAVTPAGECCPVCDNFASASRMIGETDLPASRREMVTLFSTFWVPLINLCKLQGFPGPPGFDGEPGIPGNPGEPGPPGHPSHPGGNLVTQMASGFSEKSGPSAMLTGSRVMHNRLPFQGEAGPRGLPGPSGPPVRSVPKNVTFNFPAQGPAGGQGIPGEAGDPGLMVHSFLHLGLTLMLLYMLKTPGFKGEAGLKGERGDHGAPGPLGPMGEDGKRGPRGDAGSIGPPGSPGETGPPGNRGFPGADGLPGPKGAQGERGLPGSSGAKGLSGDPGRNGESGLTGARGLTGLIGAQGAEGKQGPVGSAGDDGKQGPAGSTGNRGPAGPMGLPGPKGFLGDAGKAGEAGSPGAPGQRGPNGKDGERGAAGPPGPAGPAGKRGEQGSQGIGEVGATGPRGERGSPGERGETGPNGLQGPKGSPGAPGPDGLKGSHGPKGAAGEPGGPGLQGIPGERGIPGSSGPKGDAGLPGPIGPAGSSGPNGVKVSIKAVFQPRNVFGSTGEPGPTGAAGFPGPPGPDGQPGVKGETGETGLKGEAGSPGPQGVAGKPGEQVRFTFMFVFQGAVGADGPIGAPGKQGPPGIRGENGGQGRQGEHGPPGPPGGSGEKGESGEDGPPGPDGPPGPAGAAGQRGIVGQPGVRGERGLLGLPGPAGQPGKAGAPGPQGSTGPPGGIGLPGATGPRGDPGPEGIVGAEGPPGKDGLVGERGDRGNPGPEGLAGGPGSPGTEGPVGITGSPGQMGVNGERGPPGPQGQPGIRGKVGPQGPQGDKGAAGEPGERGQKGHRGFTGLQVLMYSFVGPRGPPGVVGPPGKEGNIGHPGAMGPPGSRGSSGDIGAQGPPGEPGPPGPPGSPGPPTSLSEDLFAGLVDYEAQGIPEFNKDEALPNKNSATLRADTGIHATLKSLSGNLQNFRSPDGSKRNPAKTCQDIKNCYPQKSSGQYWIDPNQGSVKDAIRVFCNMETGETCISANPPNIPRKAWWSKSRPNDNKPICCSYDEQPNAVAVQLKLLQLLSKESHQNVTYHCRNSVAYNDENSGDLKKALVLRAFNGQELRAQGSNRLRYTVIEDGCSKSNGAWGRTVIEYRTQTSTRLPIMDLAPMDIGQADQEFGLDIGPVCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CG20</accession>
    <name>A0A3P9CG20_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CG20"/>
    <dbReference type="Ensembl" id="ENSMZET00005021944.1">
        <property type="protein sequence ID" value="ENSMZEP00005021243.1"/>
        <property type="gene ID" value="ENSMZEG00005015947.1"/>
    </dbReference>
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        <property type="component" value="LG8"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
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        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20058" checksum="33ADBA4A98CFE6E4" modified="2019-02-13" version="1">QRLSGVALITIGVLQYSTYSDIGTFTGSNLSKIAIVLIAVGVIIAFVSLLGHIGAFFNSSSMVALSLSLQFKCCGADSYADWSQSVGWEKHDAVPDSCCVVKSEGCGQDKEKAHKKGCLWAISVFLLKNLVWVGAVCIALGVTEVSFCNFPLLTFNCEAKCSHCKSKCHITVRNDHFKCQSSTLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJQ7</accession>
    <name>A0A3P9CJQ7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJQ7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022061"/>
    <dbReference type="Ensembl" id="ENSMZET00005022795.1">
        <property type="protein sequence ID" value="ENSMZEP00005022061.1"/>
        <property type="gene ID" value="ENSMZEG00005016443.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182879"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF301">
        <property type="entry name" value="CYP2J25 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="594" mass="65082" checksum="62A6BB131E184611" modified="2019-02-13" version="1">MSGWVSDATSLGTPQALQGLEAYLHPPPLPLPVADSLRCRCVGVLCVWGWASGYTPAHSLAAACWGLGPGARSGPFGGGVPPASRPRARSLRRSWGPAELTGASLQLPLTSAPRLLGEPSSGTLLSSYWDSGVAAPLLVFHGLLCSGGLWMSGVLISSIPASHPGGRGCGPPTLPSRSLHGETFGMQYGNVFSLRLFGGRIVVVNGYKSVKEALVQKGEDLIDRPVIPIFELAENRGGVGLVMSNGYPWKQQRKFALHTLRNFGLGKKTLDLSIQQECQYLIEAFADNQGKPFNTQSLINNAVSNIICCLVFGNRFDYTDKEFQSILQKFNKIMHLQGSLSVQLIEFVKVKVNEHKENIDPSSPRDYIDAFLIEMGEVKSGFDLQNLCFCALDLFGAGTETTTTTLHWGLLYMIYYPDIQGRVQAEIDAVIGSSRQPSMSDREKMPYTDAVVHEIQRMANIIPLNLAHMTSKDTTLDNYAIPKGTIIITLLHSVLCDESMWETPHTFNPQHFLDQDGKFRKREAFMPFAAGKRVCLGEQLARMELFLFFTSLLQRFSFTAPAGEQPSLEFKLGVARAPNLIASVLYHDKAINGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CK12</accession>
    <name>A0A3P9CK12_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">SOSS complex subunit C</fullName>
            <shortName evidence="6">SOSS-C</shortName>
            <shortName evidence="6">SSB-interacting protein 1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 6">Sensor of single-strand DNA complex subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5 6">Sensor of ssDNA subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4 6">Single-stranded DNA-binding protein-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SOSS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SOSS-C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CK12"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022161"/>
    <dbReference type="Ensembl" id="ENSMZET00005022903.1">
        <property type="protein sequence ID" value="ENSMZEP00005022161.1"/>
        <property type="gene ID" value="ENSMZEG00005016622.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006366"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031821">
        <property type="entry name" value="SOSSC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31526">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31526:SF2">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15925">
        <property type="entry name" value="SOSSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="73" mass="7942" checksum="ED8E430E1C3B09F1" modified="2019-02-13" version="1">MQSQSMNTPGASISLARPSVKDFRDNAEQQHIAAQQKAALQHAHAHSSGFFITQDSSFGNLILPVLPRLEPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLY1</accession>
    <name>A0A3P9CLY1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homo- and heterotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLY1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022836"/>
    <dbReference type="Ensembl" id="ENSMZET00005023588.1">
        <property type="protein sequence ID" value="ENSMZEP00005022836.1"/>
        <property type="gene ID" value="ENSMZEG00005017086.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155002"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00764">
        <property type="entry name" value="Eukaryotic_PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000001">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000003">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000043">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase, platelet type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000064">
        <property type="entry name" value="Phosphofructokinase, platelet b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000086">
        <property type="entry name" value="Phosphofructokinase, platelet b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041914">
        <property type="entry name" value="PFK_vert-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF5">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, PLATELET TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="21"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="406"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="406"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="301"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="532"/>
            <end position="536"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="577"/>
            <end position="579"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="665"/>
            <end position="668"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="790" mass="86485" checksum="BCD748EA1B74FEB2" modified="2019-02-13" version="1">MAQPDSKKIFFENLSGAGKAIAVLTSGGDAQGMNGAVRAVVRMGLYVGAKVYFIHEGYQGMVDGGDNIKEATWESVSSMLQLGGTVIGSARCKEFRTHEGRLKAAHNLVQHGITNLCVIGGDGSLTGANLFKEEWSGLLNELVEQGLIEADAVQKYSALHIVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSGLACGADWVLIPEMPPEDGWEEKMCQKLSANRAGMKRLNIIIVAEGAIDRNNKPITTEYVKNLVVKCLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVLALLETTANTPACVVSLCGNTSVRVPLMECVQMTQEVQKAMDQKRFEEAVKLRGRSFENNLKTYKLLAHRKPESELPTSNFNVAVLNVGAPAAGMNAAVRSAVRVGISEGHKMFAVSDGFEGFYKGQIKEVKWGDVGGWTGQGGSLLGTKRTLPAKHVEKIAEQMRKHNINALLIIGGFEAFESLLQLYEARASYEEFCIPMCMLPATISNNVPGTDLSIGADTALNAIVETCDRIKQSASGTKRRVFIIETMGGYCGYLATVGGLASGADAAYIYEEPFDIKELQANVEHLTEKMKTSIQRGLVLRNENCNENYTTDFIYQLYSEEGRGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMQWVSKKLVETFRQGAGRVFANTEDSCCLLGMRRRTLVFQPVVQLKDETDFVHRIPKEQWWLKLRPLMKILAKYKTSYDVSDSGQLEHVVHNRPKDSDASVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMI2</accession>
    <name>A0A3P9CMI2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SREK1IP1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Possible splicing regulator involved in the control of cellular survival.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562050.1">
        <property type="nucleotide sequence ID" value="XM_004561993.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMI2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023282"/>
    <dbReference type="Ensembl" id="ENSMZET00005024043.1">
        <property type="protein sequence ID" value="ENSMZEP00005023282.1"/>
        <property type="gene ID" value="ENSMZEG00005017431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464065"/>
    <dbReference type="KEGG" id="mze:101464065"/>
    <dbReference type="CTD" id="285672"/>
    <dbReference type="GeneTree" id="ENSGT00510000047710"/>
    <dbReference type="OrthoDB" id="5596742at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437:SF1">
        <property type="entry name" value="PROTEIN SREK1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437">
        <property type="entry name" value="SREK1IP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="175" mass="20246" checksum="E1BBF8ED3EB824B6" modified="2019-02-13" version="1">MAVPGPNKDNIRAGCKKCGYPGHLTFECRNFVKVDPHKDIVLDVSSTSSEESEDDEPQVQRGEKRSGQHRKGSHDSDDDRKRRRKRKKSKDRKSRKRSDSSSSDEEELSKKKKKRSRSRSSSDVERRKKKKKIKSQKKKSKKNKKEHGKHHKKREKKRKHESSSSSSSSDSSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CND0</accession>
    <name>A0A3P9CND0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">A kinase (PRKA) anchor protein 12b</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004541779.2">
        <property type="nucleotide sequence ID" value="XM_004541722.4"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005023835"/>
    <dbReference type="Ensembl" id="ENSMZET00005024618.1">
        <property type="protein sequence ID" value="ENSMZEP00005023835.1"/>
        <property type="gene ID" value="ENSMZEG00005017831.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101480247"/>
    <dbReference type="CTD" id="567365"/>
    <dbReference type="GeneTree" id="ENSGT00730000111244"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032060">
        <property type="term" value="P:bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060028">
        <property type="term" value="P:convergent extension involved in axis elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070121">
        <property type="term" value="P:Kupffer's vesicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055001">
        <property type="term" value="P:muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010739">
        <property type="term" value="P:positive regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090036">
        <property type="term" value="P:regulation of protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904969">
        <property type="term" value="P:slow muscle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028540">
        <property type="entry name" value="AKAP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001573">
        <property type="entry name" value="AKAP_WSK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23209">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23209:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03832">
        <property type="entry name" value="WSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51893">
        <property type="entry name" value="AKAP_CAM_BD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding" evidence="8">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding" evidence="8">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
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        <location>
            <begin position="1426"/>
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        <location>
            <begin position="1203"/>
            <end position="1230"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <begin position="88"/>
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            <begin position="152"/>
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    </feature>
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            <begin position="171"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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        </location>
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        <location>
            <begin position="841"/>
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        </location>
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        <location>
            <begin position="1326"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1372"/>
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            <begin position="1426"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1442"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1514" mass="162012" checksum="563805E0C787A8DD" modified="2019-02-13" version="1">MGAQNSAQQDGKSQEDASASASASAGDLSAEVKAHQEGDSVLDSKSLQKNGQISSMTSLNGHSEDNTLAEVGQPDGVSVGQKEDATETMDTIQDEVTPQVNGEKVDKEAPDANDISAAEEKAPEEQPDDASEVGFKKIFRFVGFKFTLKKDKSEEKDPVKLLTVKDKEGEEGSGTDEPAKEEEEKEKEKAPAVDEKSTAEEKEADAEAAAVEVTTETVKVETTEATPEGAAAAEAVDEAVKEEGAEKEGESTSPPQEAAMSPFRKFFSGGLFSNLRKKASIKKPKEEEVNEVATEEETAKTEETVTAVEEKEVKDVTEKETEEEVLEAAVEEKSEPKEEAAITPQETKSEDHPEPEVTAETPAVAETTNDEVKQEEQKAEPPTGVEAKAPTEVTSEAELLSSQEKAKPQGSPLKKLFTGAGLKKLSTKKPKTKKDTEAKLTESGEQAAEQLQASTEPAEAPKTDSGPSSPEESGEHVIAVEVTQNESSQETEGEVGSDGEKKKEGIMAWSSFKKLVTPKKRVKRSSESEDEAAAEKPAKSATLSSSESAALADKSVEEEAKEDKPSEEEPKTETTEKLLSSTEEPKKKMDTSVSWEALMCMGGPKKRGRKTSDSDDDETKIEEETPATAEVEKEGKTEAATDTEGEPVSSPEPLPSPPERESTWGTLKRMVMPKNKAKSEEKPDESAEQVQSDSEAPKDESSFSLRKFFPGRKKKKVEKQSSTDQSSGEEDSETPAVVPLSEYDAQVEAEPEAQAEPAPVQIKVSSEDRSPSWIPADVEDAADKHDQLSDIPEEAENAATPKSIDTDIAEDETEDPAMLPKPPGRTGRRLSVAEVKPVDPAPAAATTPVPQTPKSENAEEVMQGVESQISEIPSQTCVAVEDVRLEVAAEKTEPEPPIDSAKATTNTILEPHTHDDAMAICTGLGTKEIAKVALEKPAQPLVETVAVIRDSLCSEVSVEELDPPTVEAVFTEDPVLTAQVQLLEPTELQVAVESSGSDGTIQVASLCQEPEIEKVGVVNTVTEESEVLQPTTVSENSPKTVLVSPIAPTSEAVICTQSVEVCEVTVETKEVEMEMEHFAATEDIPVQEVFQATAAEMSSDICETTKTTITEETDPPIPVVLPSEAVSVIIDTVVLVAPVSVEAEKAAATESASESKVADVEQFNSQETTKEVAKTAEAAATPIVETVISSLVSSEKTSKASLLAGLAKQASEKTEEIKEEAQQVSEIEVQSMAIAQTVIQDAVDKVSEDVPEPKKPPTPSAAIPTPVQAIATTENEIDIAADAPVVTETPVPIVCVKPVTKSPQPLNVAIQVIDAIPIEVTENLEEVEKKPEEGQKQDAEIKVSEETLKTEEAGQVKEESQESEEPAQVKEVQSKDQEEAPEKVESQSEETKPEASSEEKKEKVLEVHMPIQVVLQTALVVEEPSIEEEAVEEFDSNGPAAQDTNAPPKSSGSEKLPVLEEEPQAINAVEDAAGTSEAEKTPSKCAEVMAQVIEVIEEAVKEIEPVSTEITAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CP62</accession>
    <name>A0A3P9CP62_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CP62"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023581"/>
    <dbReference type="Ensembl" id="ENSMZET00005024355.1">
        <property type="protein sequence ID" value="ENSMZEP00005023581.1"/>
        <property type="gene ID" value="ENSMZEG00005017637.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014159"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="12">
        <location>
            <begin position="388"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="462" mass="52414" checksum="48F1E9E2DCB31A81" modified="2019-02-13" version="1">MKLRVQLQCKNLHEYLKELSPEILDRLYNHPATCLAVYRELPSLAKNYVMRMLFLDQPLPQAAVALWVKKDSQKDHDECVSVLAGLRLWHSQQLQGGLQGYILNPVFKDNLRTALLGGGRAWADEGSTLGPDRHARDIESLDRYAMERWEIILQFMVGSPSAVSQDLAQLLVQAGLMKSEAGEAPYITSAGFQFLLLDTASQLWYFTLQYLKTAQSRGMDLVEILSFLFQLSFSSLGRDYSVEGMSESLLTFLQHLREFGLVFQRKRKSRRYYPTRLAITLAAGVASSSSSSNLASSPGTGDAGFIVVETNYRIYAYTNSELQIALVALFSEMLYRFPNVVVAQLTRESVQQAIANGITAQQIIHFLRTRAHPVMLTRTPVLPPTITDQIRLWELERDRLQFTEGVLYNQFLSQADFEVLRDRAQGLGCLVWQDVAHRVMVVTPQGHSEVKRFWKQVKMHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPF7</accession>
    <name>A0A3P9CPF7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 20">V(D)J recombination-activating protein 1</fullName>
            <ecNumber evidence="3 20">2.3.2.27</ecNumber>
            <ecNumber evidence="20">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="20">Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="18">The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18 20">Belongs to the RAG1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3 20"/>
    <dbReference type="EC" id="3.1.-.-" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPF7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023671"/>
    <dbReference type="Ensembl" id="ENSMZET00005024448.1">
        <property type="protein sequence ID" value="ENSMZEP00005023671.1"/>
        <property type="gene ID" value="ENSMZEG00005017704.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008679"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097519">
        <property type="term" value="C:DNA recombinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905347">
        <property type="term" value="C:endodeoxyribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990238">
        <property type="term" value="F:double-stranded DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065004">
        <property type="term" value="P:protein-DNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033077">
        <property type="term" value="P:T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033151">
        <property type="term" value="P:V(D)J recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16530">
        <property type="entry name" value="RING-HC_RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024627">
        <property type="entry name" value="RAG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058557">
        <property type="entry name" value="RAG1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058552">
        <property type="entry name" value="RAG1_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035714">
        <property type="entry name" value="RAG1_imp-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058553">
        <property type="entry name" value="RAG1_pre-RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058554">
        <property type="entry name" value="RAG1_RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058555">
        <property type="entry name" value="RAG1_ZnC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019485">
        <property type="entry name" value="RAG1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058556">
        <property type="entry name" value="RAG1_ZnH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023336">
        <property type="entry name" value="RAG_nonamer-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058558">
        <property type="entry name" value="RING-HC_RAG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11539:SF0">
        <property type="entry name" value="V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11539">
        <property type="entry name" value="VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12940">
        <property type="entry name" value="RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26105">
        <property type="entry name" value="RAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26024">
        <property type="entry name" value="RAG1_DNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12560">
        <property type="entry name" value="RAG1_imp_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26025">
        <property type="entry name" value="RAG1_pre-RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26100">
        <property type="entry name" value="RAG1_RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26101">
        <property type="entry name" value="RAG1_ZnC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26104">
        <property type="entry name" value="RAG1_ZnH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51487">
        <property type="entry name" value="NBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51765">
        <property type="entry name" value="ZF_RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="15 18 20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14 18 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 20" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 20" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16 18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 20" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="RAG1-type" evidence="24">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="NBD" evidence="23">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NBD" evidence="18">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU366024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1031" mass="116630" checksum="0A06DDF0DCDD240D" modified="2019-02-13" version="1">MAAESLETDGPRSSMPPELHHPHSEYSQWKFKLFRVKSMEKAPLPSETRPEISPTAAPNIEIDHAAGPGSVMKLCLGGKSKENVEGPGSDTISLALYRGLCRVCGMVLRKVKGPVHDVHGDLDEVSKCALRKMGCKFPSWPEVILKVFKVDVTEDTESVHPLSFCHRCWMVAIRGGGVCSFTRTRVPEWKPHSSLCHLCYPKKTSFQRTGRKRRKVLPRAQSLAKRTRWDCDAIAVGERRQWVKNITRCQKDHLSTKLLSEKLPVDFVASFTCLVCDHLLSDPVQSTCGHLFCRGCIVKFTHVLGPHCPACNSPCTPDNLTSPAKVFSSALHSLPLLCPSEGCREQVRLDSFKAHCLSHELKENENLSLSELDNFLLTNKGGRPRQHLLSLTRRAQKHRLRDLKNQVKVFADKEEGGDLKSVCLTLFLLALRSGNEHRQADELEAMMQGKRGFGLSPAVCLAIRVNTFLSCSQYHKMYRTVKATSGRQIFQPLHTLRAAEKELLPGFHQFEWQPALKNVSPSYNVGIINGLSGWSSSVDDVPADTITRRFRYDVALVSALKDLEEDIMEGLRESGMEDSACTSGFSVMIKECCDGMGDVSEKHGGGPVVPEKAVRFSFTVMSVSVLADDEEEEVTIFTEPKPNSELSCKPLCLMFVDESDHETLTAVLGPIVAERNAMKESRLILSMGGLPRSFRFHFRGTGYDEKMVREMEGLEASGSTYVCTLCDSSRAEASQNMVLHSITRSHEENLERYEIWRTNPFSESVDELRDRVKGVSAKPFLETQPTLDALHCDIGNATEFYKIFQDEIGEVYKKANPSREERRSWRAALDKQLRKQMKLKPVMRMNGNYARRLMTQEAVDVVCELVPSEERREALRELIKLYLQMKPVWRATCPAKECPDQLCRYSFNSQRFADLLSTTFKYRYNGKITNYLHKTLAHVPEIIERDGSIGAWASEGNESANKLFRRFRKMNARQSKTFELEDVLKHHWLYTSKYLQKFMEAHKDSAKALQATIDPVEIQDDDEMSLEVPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQ62</accession>
    <name>A0A3P9CQ62_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQ62"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023911"/>
    <dbReference type="Ensembl" id="ENSMZET00005024694.1">
        <property type="protein sequence ID" value="ENSMZEP00005023911.1"/>
        <property type="gene ID" value="ENSMZEG00005017888.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176900"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="64" mass="7347" checksum="7A8298FF8B1B6269" modified="2019-02-13" version="1">NCSKIEVHFTSHLQNLQAQMTEFEASAEPLQEWLNSTEVRVQESSARLHDLPAKKQELSKLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CT38</accession>
    <name>A0A3P9CT38_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coiled-coil domain containing 85A</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC85 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CT38"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025192"/>
    <dbReference type="Ensembl" id="ENSMZET00005026012.1">
        <property type="protein sequence ID" value="ENSMZEP00005025192.1"/>
        <property type="gene ID" value="ENSMZEG00005018804.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157361"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019359">
        <property type="entry name" value="CCDC85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546:SF13">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 85A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546">
        <property type="entry name" value="RE60986P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10226">
        <property type="entry name" value="CCDC85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="440" mass="48347" checksum="65C5D3BCE35157AB" modified="2019-02-13" version="1">MEKSAQQQSKSAERPAEDISKIPDEELLKWGKEELVRRLRRAEAEKRGVIVEHGNLMREVNRRLQQHLNEIRSLKDVNQKLQEDNQELRDLCCFLDDDRQKGKRVSREWQRLGRYSAGLMRKEVAIYLQKLKELEQRQMEVIRENLELKEVCLMLEEERATVVAASTGGSGGGQGGPGCRSSIDSQSSLSQLGGGMPTPGLLRDVGDGSSTSSAGSTDSPDNPHHKPSPLGSNSSPGSGSRCSSSGQKRDVCEFSGRRRGSTTEYHTFPQSCRPRGGSLTNLELHSFRGHSPEKHSKSPTRLPCGSHSKPCSSDLLAQKQLLMSGQASPGSDKGSAKSSPDLSQRHRQVNSAGAGSPEAKQVAMGTPEHLRKGRVIVGSPESIRHHYHYHQSPGVEHSKGKYSSGSPGRDGSHRRPAGEEIAPHHQSLYNGRHMVTLILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CTD6</accession>
    <name>A0A3P9CTD6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CTD6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025640"/>
    <dbReference type="Ensembl" id="ENSMZET00005026473.1">
        <property type="protein sequence ID" value="ENSMZEP00005025640.1"/>
        <property type="gene ID" value="ENSMZEG00005019142.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158837"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060335">
        <property type="term" value="P:positive regulation of type II interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF70">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018167879" description="Macro domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="8">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="206" mass="22434" checksum="1FEF9C6BBF9849FB" modified="2019-02-13" version="1">MNSIFTLLFKFFCFSFLKFSHKDEEEQAATQKRIMSPHLTQDVNISVWIADLCKFQVDAVVNAANTMLQHCGGLALAISECGGTKIQKESNNYIAENGPLRTGEAIVTSAGNRSCQKIIHVVGPCLQSKPSAKDVTQAKPMLRQAIISVLQKAEEHKMCSIAIPAVSSGIYNFPARECADVITKKSFLLFCVFFGGAAILALGLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CV06</accession>
    <name>A0A3P9CV06_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 184ba</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004557607.1">
        <property type="nucleotide sequence ID" value="XM_004557550.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CV06"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025899"/>
    <dbReference type="Ensembl" id="ENSMZET00005026735.1">
        <property type="protein sequence ID" value="ENSMZEP00005025899.1"/>
        <property type="gene ID" value="ENSMZEG00005019316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484070"/>
    <dbReference type="KEGG" id="mze:101484070"/>
    <dbReference type="GeneTree" id="ENSGT00940000153861"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
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    </feature>
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        <location>
            <begin position="190"/>
            <end position="212"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="249"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="426" mass="47806" checksum="53F96DC28342F62B" modified="2019-02-13" version="1">MLKLWRRDVPLSERLGEDSPLVPAPGPPPTAAPMGPNISWLPDAPLLSSDPPIFLMTPATQAVSGFFVWTALILTCHQIYMHLRFYSSPREQRHIVRILFIVPIYAFDSWLSLLFFTNDQYYVYFDTVRDCYEAFVIYNFLSLCYEYLGGESAIMAEIRGKPIESSCMYGTCCLRGKAYSIGFLRFCKQATLQFCVVKPLMAVITVILQAYGKYKDGDFNVASGYLYVTIIYNISVSLSLYALFLFYFATRELLSPYSPMLKFFMVKSVIFLSFWQGMLLAILEKCGAIPQINSVEVSVGEGTVAAGYQNFIICIEMFFAALALRHAFTYSVYKDKSLDLTGPVPTYGQFGRCAPMKSISSSLKETMNPGDMVQDAIHNFSPAYQQYTQQSTLEQGAPPPVSRAHSAVSGRGDTEKTLLLSSDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CWL8</accession>
    <name>A0A3P9CWL8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SUN domain-containing ossification factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Membrane protein CH1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">SUN-like protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Rough endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004557265.1">
        <property type="nucleotide sequence ID" value="XM_004557208.4"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005026372"/>
    <dbReference type="Ensembl" id="ENSMZET00005027224.1">
        <property type="protein sequence ID" value="ENSMZEP00005026372.1"/>
        <property type="gene ID" value="ENSMZEG00005019677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464620"/>
    <dbReference type="CTD" id="51430"/>
    <dbReference type="GeneTree" id="ENSGT00390000013502"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046850">
        <property type="term" value="P:regulation of bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000024">
        <property type="entry name" value="SUN domain containing ossification factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018185811" description="SUN domain-containing ossification factor" evidence="18">
        <location>
            <begin position="24"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="19">
        <location>
            <begin position="293"/>
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        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="532"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="831"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1226"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1021"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="636"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="903"/>
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        </location>
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        <location>
            <begin position="913"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1230"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1275"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034697"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055064"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067685"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075366"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1380" mass="152179" checksum="CC122866296E7A04" modified="2019-02-13" version="1">MKRLRVLLVCLIVALLCWYPSQHVYCSEQSLSGSGQPRQEKDPDGLEQEQDSTQNKVVEEWKTHTSYDMGLETERAAREKLQKQSIHHEETVKPQEAGEEETKLDPESDTVPVAPEPEPTPDPQADLGLQIHTQDHDHNAPVLATPEPVPAQGQVTTDTPAETSSEPIPNLDSNPDTSPDEAENKPTSQSAGLTHTGMDEAVTEDQQTDQRHSSGPETEIQSTPGLVDQEQEQREVLEDGLSVLEQVGNTSHHQHKKQQTGETNAPRETDPSVPSKEDIPTFDEWKKQVMEVEKEKSQSLHTSTSSSPHPTKKVQKNFKNNYASVECGAKILSANSEAKSTSAILMENMDLYMLNPCSNKIWFVIELCEPIQVKQLDIANFELFSSTPKDFLVSISDRYPTNKWVKLGTFHARDERIVQSFPLDEQLYAKYVKMFIKYIKVELLSHFGSEHFCPLSLIRVFGTSMVEEYEEIADSQYPSERLEYLDEDYDYPPGYQPTEDKASKNLLGSATNAILNMVNNIAANVLGGKPELETGAETGGNATEGGEKESTESAKPTEALHTVLQPSKPEQPTTEEVSVSSDSSTSSHSSSDPHKDVDQIVTLVEEEEEDEEIRLSTVTLLEEEGEDDEEGEKSEEEMRKEADRNQWESQAYCPFTSFSSLSLSCMVTLPELLHRWCSARLAKERLRSLKKRQLSTQTQTHPTVSTPVLTHTPPLIPIPAPTPIQEPLPLTEKAPELEVPEKGQNECRALSEEYTTDTPLSTDTPDSYTPELNILLEPSRTSTIPPQSFSNSHSSLTQPTPTPKENLLPLVKDATLDPVPTPLLQAVSIPKTQHASSVTPTLSASTPPLSQSSETASPVVTVPPVKDQPVQPLPTASRPEDFISPPTELPAALPSNDIHTDSVKSGVDSGDSQRQNVQASQTHGEQADSLPQTGEPHRVEETVEEELLNASGNGNAQRTATDFYAELQNGGDYNGGAVNGNSVLVNGGAVHGSSQKESVFMRLNNRIKALEMNMSLSSRYLEELSQRYRKQMEEMQKAFNKTIIKLQNTSRIAEEQDQKQTESIQVLQSQLENVTKLMLNLTATVSELQREVSDRQSYLVVSLVLCLFLGILLCLQCCRSSAPGPSTNSTALPKSNHYPSPKRCFSSYDDMSLKRRVTCPLVRSKSFHLSSTEVGPDDLYIVEPLRFSPEKKKKRCKAKSLDKVETLKAFDPSALLTNGDPKFNSFHPCLPAPPSSTRPLPLPPPPPPPPPLPPPPSTPQEGPLLPRRTSKEFPSETSSCSSSTHSEESYASRLPPPSPVFPADGVCNGHGLSFPLSQPVAKSRQEKRSTKRRKSRQTELQFPHMPVGSVGSLPSLQQLMKGNKEMSVGTIGVTAVTGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CY06</accession>
    <name>A0A3P9CY06_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PR domain zinc finger protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PR domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CY06"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027240"/>
    <dbReference type="Ensembl" id="ENSMZET00005028111.1">
        <property type="protein sequence ID" value="ENSMZEP00005027240.1"/>
        <property type="gene ID" value="ENSMZEG00005020318.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00890000139463"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19192">
        <property type="entry name" value="PR-SET_PRDM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000012">
        <property type="entry name" value="PR domain zinc finger protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044402">
        <property type="entry name" value="PRDM8-like_PR/SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052296">
        <property type="entry name" value="TR-Histone_Methyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516">
        <property type="entry name" value="AGAP007109-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16516:SF7">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="19">
        <location>
            <begin position="140"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="311"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="447"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="692" mass="76351" checksum="F35CEC077A4B9B66" modified="2019-02-13" version="1">MCRKQKVCVGVPVSQSIGPHLHASLSPSLSLSAFIRAALSPCPAPSLPVSAAAAALSLSAHWGGNVLILRSSPGAHHHLHHHLHHRHRIPPLVFSGLFSPALIRSIALKSFVDYCSLLIDGKCDMEESSSQKLVWDGDAKAVQQCLTDIFTSVYTTCDIPENAIFGPCVLSHTSLYDSIAFIALKSTDKRTAPYIFRVDTSAANSTSEGLMWLRLVQSARDKEEQNLEAYVKNGQLFYRSLRRIEKDEELLVWYGKDLIDLLLLSSSRVPPKSKGSSHHSCPDCSQRFQFEFPFLAHLRFRCTKRLQSIAAADEEPSKDSGTERLNATPTRTSPKVVRSEGFSSHQDNNKPSTDFHNLARDLENNRTSPPSDKEAEICSESSGKRKFSEIEDRECRGPSLPQSKSKDELATSVQNYRGAYGLEDNHRSFSPPGSIELGEVKRSAFTEVKSAQHSKQHSSSKSLQSSNSENKDGGRPSSNPSEKHLSIRSVLSETQPPQSSPMGSAFTSVSQQGGGSGGERKSAFSQPSRSFSQISPLVMPPKLLDCHPAVGDTISSNRLYQADHLAAKLQGAELGANCPVPGGMAKQNPFVYATAFWPKNSGPIQLQMPSALTLLPPSFTSLCLPAQNWCAKCNASFRMTSDLVYHMRSHHKKEYSMEPLVKRRREEKLKCPICNESFRERHHLSRHMTSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CY08</accession>
    <name>A0A3P9CY08_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GTPase IMAP family member 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Immune-associated nucleotide-binding protein 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CY08"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026882"/>
    <dbReference type="Ensembl" id="ENSMZET00005027746.1">
        <property type="protein sequence ID" value="ENSMZEP00005026882.1"/>
        <property type="gene ID" value="ENSMZEG00005020059.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282522"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000536">
        <property type="entry name" value="GTPase IMAP family member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF107">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AIG1-type G" evidence="16">
        <location>
            <begin position="24"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="249" mass="28770" checksum="19E03AB2647E38B8" modified="2019-02-13" version="1">MQHDIFPFHFALTAVFFSVSSNKLQELRIILLGQKTVGKSATGNTLLHKEVFASSQNEQCQMQDGEVSGRRVTVIDTPGWWQDSSCCTDEIDKEIARGFSLSPAGVHVILLVIPLDLTFRDSQRVTLEDHMNLFHATVWKHAMVLFTYGDKLADKSLEEHIEREHSALRWLIEKCENRYHAINNMKKMDMNQVTELFEKIEEIVAGNSGKLFCPNMNEMHLRFEEMFKRKQLKHWISGSCRAKLSIWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYA4</accession>
    <name>A0A3P9CYA4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CYA4"/>
    <dbReference type="Ensembl" id="ENSMZET00005027842.1">
        <property type="protein sequence ID" value="ENSMZEP00005026977.1"/>
        <property type="gene ID" value="ENSMZEG00005020122.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182912"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF27">
        <property type="entry name" value="SI:CH211-193K19.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="127" mass="14084" checksum="9CD72191C046C74D" modified="2019-02-13" version="1">MEQTVMGVYVIHQEGAEPGDDPENIGVLIEGVEVLTGLRSIAIACALLFGLIYCLNLSYPPELKCTFEVLQKIIMKLDGQRLSSKAQFLKNKYAHGCSLFVDLNYTFLGCYFKAHCALSVLRAAQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZB0</accession>
    <name>A0A3P9CZB0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Piezo TM25-28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZB0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027673"/>
    <dbReference type="Ensembl" id="ENSMZET00005028552.1">
        <property type="protein sequence ID" value="ENSMZEP00005027673.1"/>
        <property type="gene ID" value="ENSMZEG00005020637.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164142"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF7">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT 2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="2">
        <location>
            <begin position="207"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="302" mass="35316" checksum="55F29D48D3D7AD6B" modified="2019-02-13" version="1">NHLMVLGLLVFESTVHRHQLYFRLNNSLKPPPFSIIFQGITRQHLDHGILPCIKYFINFFFYKFGLEISLIVAVNVIGQRMDFYALLHSCALLAVLSRRRRKAIGEVWSKYCTFTAGLMVLQYLLCIGIPPAFCVYPWRTAVHPLSSNVIKWFYMPDFAMRPNPLFIFDYLLLLCSSLQWHVFEEENRAAVRLLAGDNVEISRSLDPCSFNQFIPVDNFLHCCYLDMVKVFVFSYFFWLVLCLIFITGTTRINIFCLGYLVACFYFMLFGGSVLMQPVRYILRLWDWLIGYTCFVIAMKNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D096</accession>
    <name>A0A3P9D096_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aldehyde dehydrogenase family 6 member A1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(R)-2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:141212"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76624"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62413"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:76628"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-methyl-3-oxopropanoate + NAD(+) + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20804"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:20805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-oxopropanoate + NAD(+) + CoA + H2O = hydrogencarbonate + acetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76615"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:76616"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004540705.1">
        <property type="nucleotide sequence ID" value="XM_004540648.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D096"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027779"/>
    <dbReference type="Ensembl" id="ENSMZET00005028662.1">
        <property type="protein sequence ID" value="ENSMZEP00005027779.1"/>
        <property type="gene ID" value="ENSMZEG00005020704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483820"/>
    <dbReference type="KEGG" id="mze:101483820"/>
    <dbReference type="CTD" id="4329"/>
    <dbReference type="GeneTree" id="ENSGT00940000156110"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="526" mass="57046" checksum="03EEAC1C88CB8B52" modified="2019-02-13" version="1">MASTALRSAFRTKVPFRVGRLCYSSSSVPTTKLFIDGKFVESKSSEWLDIHNPATNEVITRVPKATQEEMLAAVDSCSRAFRSWSETSILARQQVFLRYQQLIKDNIKELAKAITVEQGKTLADAEGDVFRGLQVVEHTCSITSLMLGETLPSISKDMDTYTYRLPLGVCAGIAPFNFPAMIPLWMFPMGMVCGNTYLLKPSERVPTCAMLLAKMLQDAGAPDGTLNIIHGQHDAVNFICDHPAIKAISFVGSNQAGEYIYERGSKNGKRVQSNMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAILVGEARSWLPELVERAKALRVDAGDQPGADLGPLISPQARNRVCSLIQSGVEEGAKLLLDGRNIKVKGYENGNFVGPTILGNVTPQMKCYTEEIFGPVLVVLEADSLDNAISLVNKNPYGNGTAIFTTNGATARKYTHEVDVGQVGVNVPIPVPLPMFSFTGSRGSFRGDTNFYGKQGIQFYTQIKTVTAQWKAEDATLKSPAVTMPTMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D0S5</accession>
    <name>A0A3P9D0S5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
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                <person name="Amemiya C."/>
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                <person name="Baroiller J.F."/>
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                <person name="Ribeiro F.J."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
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                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
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                <person name="Venkatesh B."/>
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                <person name="Meyer A."/>
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                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8A6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030793"/>
    <dbReference type="Ensembl" id="ENSMZET00005031772.1">
        <property type="protein sequence ID" value="ENSMZEP00005030793.1"/>
        <property type="gene ID" value="ENSMZEG00005022938.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00440000033408"/>
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        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF10">
        <property type="entry name" value="PLEXIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="337" mass="37401" checksum="DB66A647DB779A49" modified="2019-02-13" version="1">MNDVRHGQVRVHGILSNSYKQAVRVALSFDFPFYGHYLRQITIATGGFIFTGDITHRMLTATQYIAPLMANFDPSYSKESTVQYLDNGEVFVVQWEHVRIPGKESVGGFTFQVALYKTGTITFSYRDIPLSVDVISSAEHPVKAGLSDAFMVMSPSSQSADLPRQMIYEYHRVEIDVTKITNYSAVEFTPLPTCLLHDSCELCLSASQTSGCSWCHVLQRCSDGMDRHRQEWLDYACAEESQGATFPDVKTDSSTKSVGFANTGLIAGLASALVLLLALILVSLYISYHPSAVSPLYLIQRRKSYWPSLKFQKQESGYTEVEGGGHEKDSIVEAGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8W5</accession>
    <name>A0A3P9D8W5_9CICH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="112" mass="12224" checksum="410C5387CEAA6133" modified="2019-02-13" version="1">GALSSTSSASFEQPSSQEHLKSPEAFTPTSLPAQRLHTGSTTKEAGAVLTKQLVDTASLLAVLLFGLLFFLVTVSVFVKLAYDSYKRKDYTQVDYLINGMYSDSGQEMEKVH</sequence>
</entry>
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    <name>A0A3P9D8Z9_9CICH</name>
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        <submittedName>
            <fullName evidence="10">HEXIM P-TEFb complex subunit 1</fullName>
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    </protein>
    <organism evidence="10 11">
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        <name type="common">zebra mbuna</name>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
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                <person name="Amemiya C."/>
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                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
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                <person name="D'Cotta H."/>
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                <person name="Gaffney L."/>
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                <person name="Greuter L."/>
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                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
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                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
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                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
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                <person name="Searle S."/>
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                <person name="Swofford R."/>
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                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
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    <dbReference type="RefSeq" id="XP_004552429.1">
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    </dbReference>
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    <dbReference type="Ensembl" id="ENSMZET00005031808.1">
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        <property type="gene ID" value="ENSMZEG00005022967.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477097"/>
    <dbReference type="KEGG" id="mze:101477097"/>
    <dbReference type="CTD" id="10614"/>
    <dbReference type="GeneTree" id="ENSGT00390000002808"/>
    <dbReference type="OrthoDB" id="10058500at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02094">
        <property type="entry name" value="HEXIMFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="359" mass="40613" checksum="F0C18922F6E628FE" modified="2019-02-13" version="1">MTEPEETTHHLKTSASPSGGSSGDALEHLPARNHDGPQNGDRGRQSEHKQEQRAENCEDINTDKLRQMKGGQREVCPGLAAGNEVQKCPISTQPHQKRSIQGATGDHHTTQGKNAQDRRLQVQVDSLHIDSDTGLDARLGKKRHRRRTSKKKRHWKPYNKLSWEEKKALEEKETARASRIREEMFAKGLPVAPYNTTQFLMDEHDREEPDLNTQMGVRRPSGVGVCMEDTGSEDEVLENEDQDYDDGSGGGSDGIGRPGNAGGEFLQRDFSETYEMYHVESLQNMTKQELVKEYLELEKCMSRLEEENNRLRRAVEPGGQNCSVRVKEMEKELERLKAQNMELLLKSQPSKDRGQVATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9J3</accession>
    <name>A0A3P9D9J3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear GTPase SLIP-GC</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9J3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031421"/>
    <dbReference type="Ensembl" id="ENSMZET00005032384.1">
        <property type="protein sequence ID" value="ENSMZEP00005031370.1"/>
        <property type="gene ID" value="ENSMZEG00005023384.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005032440.1">
        <property type="protein sequence ID" value="ENSMZEP00005031421.1"/>
        <property type="gene ID" value="ENSMZEG00005023384.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007091"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053082">
        <property type="entry name" value="Nuclear_GTPase_SLIP-GC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47308">
        <property type="entry name" value="NUCLEAR GTPASE SLIP-GC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47308:SF1">
        <property type="entry name" value="NUCLEAR GTPASE SLIP-GC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="1">
        <location>
            <begin position="173"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="795" mass="90869" checksum="8F620B06FAB40263" modified="2019-02-13" version="1">MDDFVRNTLLEWGLSDWVEKFKDEQINAESLYYLDDREIDILIPKAGPRVIFKNNLKLLKEHEEAAGLVQEEQNSNQEPIVFFQLEQEHEEAADVGQVLPSTSSKGKRKSDLQAESLKCFPAAKRRCDSDTRILSEVKRIMKQIKDQINDKEELGAFIKNKISDLEINKRELVGVFGRTGAGKSSLINAIIDEKNLLPTGSISACTSVVIKVEANTRSLKYEAEIEFIKEEEWHDELWSLKTYKKGDDDYRDMVKKLSALYGDEWKDKSPENLIEPKYFKNIPEFLASKRKSLNCDTAQELSQKLRIYTKGGPKQEDGSKAQQWFWPLVKSVTVRVPHNELLQHVTLVDLPGNGDRNKSRNEMWKQIVVDCSTVWIVAEITRAASEVEAWEILKSAHGLIGNGGQCQQIHFICTKSDPADDRVPNNKEAKEEVMNEFQELSEQFSDKGFKVFTVSADEFLKRKRVKEDDNEIPKLQDFLQNLNDCHSETINYVNGAYGILSLIEGARCSKAGVGKADDVCKVLEKNMREELDQVKSAVDEAIKDFEQCLTEGVKNSKTSEERLKFFLDRDQEPSFFKTLQAVVRKDGIHQTKKGEQINLNTVLASCLTDSIDEKFRKTFPNDVKGGSFSGVISRFSLDTNSLIQKYQDVKLQLIFLQTEEDKIKAKLNKIILKGKKIIYNSLTETIEKNMKKCYEDAQKISGTDALKKMRKTIETHVSLNRNMYEDAKKTMMKKMNILMKIICKELEETMDHSIKHSLKASTLSESLPDVSGDLETVQQHYNEVKRSQEGEMTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9M9</accession>
    <name>A0A3P9D9M9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 217</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560380.1">
        <property type="nucleotide sequence ID" value="XM_004560323.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004560381.1">
        <property type="nucleotide sequence ID" value="XM_004560324.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004560382.1">
        <property type="nucleotide sequence ID" value="XM_004560325.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004560383.1">
        <property type="nucleotide sequence ID" value="XM_004560326.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012777064.1">
        <property type="nucleotide sequence ID" value="XM_012921610.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9M9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031410"/>
    <dbReference type="Ensembl" id="ENSMZET00005032427.1">
        <property type="protein sequence ID" value="ENSMZEP00005031409.1"/>
        <property type="gene ID" value="ENSMZEG00005023413.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005032428.1">
        <property type="protein sequence ID" value="ENSMZEP00005031410.1"/>
        <property type="gene ID" value="ENSMZEG00005023413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484271"/>
    <dbReference type="KEGG" id="mze:101484271"/>
    <dbReference type="CTD" id="7764"/>
    <dbReference type="GeneTree" id="ENSGT00940000159884"/>
    <dbReference type="OrthoDB" id="8953863at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000965">
        <property type="entry name" value="Neurotrophin receptor-interacting factor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051967">
        <property type="entry name" value="Krueppel_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45925:SF4">
        <property type="entry name" value="ZINC FINGER PROTEIN 217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="296"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="392"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="503"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="650"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="821"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="958" mass="106164" checksum="9E6C1E765A4F7352" modified="2019-02-13" version="1">MPTHSLLPFVNSPDGLAQDFLISKDASIPGLGSSMTPHTTYPEKTELQNEESAPLYCMFCEETFAHQDELGPHVLTQHPTTFSEPTVLRVEAEFRIPGERPRAKQSSLPAEKDEVHSCILCGHLSQDGSELEAHMRKHKDYFTYCCNFCGRRFREHWFLKNHMKMHVKAGAKNKTQQDPESPITINGIIQEPPSEPVGTAYKMCMVCGFFFPDHDSLVEHSKMHNREAQPGKDKSKDKMGDTNEPTANQDSFLQFLNLQPRPAGKDVEPVRSSKWIPQLDPVNTYQAWQLATKGKIAVGPNNTKDVGQENSTDNDESGSDKDELNNIWTEGQGDKAVKEVGRELRSQQQAPVKSPDPQRRSPVQKDKDKQRPTTCEECQRNFRTYHQLVLHSRVHKRERGGEESPTSSVDGKLSRAGSLENTEEGSEEGIEENLGSGEDGFDRSNGRSKDCSYCGKTFRSSYYLTVHLRTHTGEKPFKCAYCEYAAAQKTSLKYHLDRRHKDKPYVEIPSRPVPLVPSPSDGKNENNAENSVPKKSCVPPARPCIDETLESGLDSVDGKLGKPLVQVNAVPACSPEDDALANCSVPVNLKKKREEVQEENCEAPLNLSIKVSVSTPVSVEPRNGIVPIACPFCAYKTIYPEVLIMHKKLSHKDKSNSTKKNGFGGNLSESRHTGCPPALNGKDVSSVLITERIFPRRTKSPPPQPAKPQEKTPVNLPHVPKPSPVHAPIKDVQETQRYRQSTDSHPSQESSRYTELMRKNSTTNKYIMDRVGIGDRSYPVRSGVLWHTDAARLCLSSRFGSLPQMDFGEPSSKRLKFSVPTNRDAEAGEKAAFRGPPADGSNRMFTKRTVKPTQQGSCPPTASEVSVLGPAKNAPTTIGGSLESEWSMMNLLRSYPPHDLASFYHTNPANPSHVGLVNPGAGGRSVLFQHLPSLPSLQRRDVSGPFPSQRCGATDKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAS0</accession>
    <name>A0A3P9DAS0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multifunctional ROCO family signaling regulator 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004561914.1">
        <property type="nucleotide sequence ID" value="XM_004561857.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004561915.1">
        <property type="nucleotide sequence ID" value="XM_004561858.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAS0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031236"/>
    <dbReference type="Ensembl" id="ENSMZET00005032247.1">
        <property type="protein sequence ID" value="ENSMZEP00005031236.1"/>
        <property type="gene ID" value="ENSMZEG00005023295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474334"/>
    <dbReference type="KEGG" id="mze:101474334"/>
    <dbReference type="CTD" id="9258"/>
    <dbReference type="GeneTree" id="ENSGT00940000158928"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057263">
        <property type="entry name" value="COR-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF48">
        <property type="entry name" value="MALIGNANT FIBROUS HISTIOCYTOMA-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25497">
        <property type="entry name" value="COR-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Roc" evidence="5">
        <location>
            <begin position="406"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1027" mass="116797" checksum="F9744E3089229BCF" modified="2019-02-13" version="1">MKTLNENKEKEEEEEGSGCSAMEDKENNLKTARLWRDAALRSRKLRSNLRQLTLCSKNNQIILPEDIADIEALNLGNNSLQELPDGLGSSLNNLRVLVLRRNKFSSVPRVVFELGRLVELDMSHNCLRSLPEGVGQLRGLKKLCISHNKIQHLPAQIGALQSLEELDMSFNDLHDFPRSFSGLAHLRTLDADHNKLNQFPPEIMALSELEELDCSGNKFEVLPVDVRKLQSIKILWLSSLHMSSLPHTFCHLQHLESLMLDGNHLRELPPSFGSLQRLKMLNLSSNDFENFPQVILSITGLEELYLSRNRLIHIPEEIGQLGKLVNLWLDNNSITYLPDSIVELENLEELVLQGNQIAILPDNFGKLSKVNIWKVKDNPLIQPPYEVCMKGIPYIAVYQKELAHSQFAVKPRLKLVLMGTQNAGKTRLRQSLVSTQQDASSNQGNKGIEVTNWVADADRHLTFLVYDLSGKQNYDLIKPFFLSPGALYILVINLKTYSPKNFYTHVGYFLHLLCAKVPHAVVCLVGTHTDLCAEVEVEEKTLDIHRQIGLQEKRDIQSLRGLALQVDQALEQGYNVRTSSPHILFYGVTDKNLRRRKAQLQYMLNHRLQILSPVLRVCCTGAQRNIPRLREKLMSVAEHREIFPNLHRVLPKSWQMLEELHFKPKDLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSLTLREYVFHNLPRFIAILNVFFQRDESTLLDRLLSEGERGDKGRVSLVIEDEKGENLRVTHLQHHVEGFLQHGLLPSNVIRLLLRPLIQTQQDLHLIMELLEKMGICYCINKPRSKPLNGATVWYKFPSYVSSEEVQVDASAGGSSLPLCNFFSVEQLHIQYSFPFLFPPGLFARFSVQINSHVVQRSDSKHQIFAYRGKVPVVISHRPAKGKLQVETLSIASHASLPNIWTAWQAITPLVEELNMLLQEWPGLHYSVHVLCSKCLKRGSSNPHAFPGELLSQPRPEGLTEIVCPKNGSERVNVALVYPPTPTVLSPCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFG2</accession>
    <name>A0A3P9DFG2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hippocampus abundant transcript 1 protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing 14A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555395.1">
        <property type="nucleotide sequence ID" value="XM_004555338.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFG2"/>
    <dbReference type="Ensembl" id="ENSMZET00005033936.1">
        <property type="protein sequence ID" value="ENSMZEP00005032876.1"/>
        <property type="gene ID" value="ENSMZEG00005024480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480012"/>
    <dbReference type="KEGG" id="mze:101480012"/>
    <dbReference type="CTD" id="322115"/>
    <dbReference type="GeneTree" id="ENSGT00940000164530"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17387">
        <property type="entry name" value="MFS_MFSD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000099">
        <property type="entry name" value="Hippocampus abundant gene transcript 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="37"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="491" mass="52867" checksum="F386936236CC332E" modified="2019-02-13" version="1">MMTGEKKKKKRLNRSILLAKKIIIKDGGRPQGIGEPSVYHAVVVIFLEFFAWGLLTAPMLTVLHQTFPQHTFLMNGLIHGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISMSGVFAVTFSVIFAYVADITQEHERSTAYGLVSATFAASLVTSPAIGAYLSEAYSDTLVVILATVIALLDICFILMAVPESLPEKMRPASWGAPISWEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFSSETVAAFIAVLGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAAGAVAAMSSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFIFYLFHVELTDTDGSEKGAKPNMANPTDESAIIPGPPFLFGACSVLLSLLVALFIPEHTGPGMRPGSYKKHSNGAQSHSHSPQGSGAEGKEPLLEDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIH3</accession>
    <name>A0A3P9DIH3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer, and heterodimer with other family members.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560095.1">
        <property type="nucleotide sequence ID" value="XM_004560038.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIH3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033987"/>
    <dbReference type="Ensembl" id="ENSMZET00005035183.1">
        <property type="protein sequence ID" value="ENSMZEP00005033987.1"/>
        <property type="gene ID" value="ENSMZEG00005025415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481383"/>
    <dbReference type="KEGG" id="mze:101481383"/>
    <dbReference type="GeneTree" id="ENSGT01090000260040"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="246" mass="27843" checksum="6CDF30DB17B4FBE2" modified="2019-02-13" version="1">MSEAPQKELVQKAKLAEQAERYDDMAALMKSVTEEGLELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGSEKKVALAKDYREKIETELKEICHDVLGLLDKYLIPNATAAESKVFYLKMKGDYYRYLAEVATGDTKKGIISNSQEAYQAAFDISKSEMQPTHPIRLGLALNFSVFYYEILNIPEEACKLAKQAFDDAIAELDTLSEDSYKDSTLIMQLLRDNLTLWTSDNQVEGEDSEPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIH4</accession>
    <name>A0A3P9DIH4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate decarboxylase like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIH4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033941"/>
    <dbReference type="Ensembl" id="ENSMZET00005035137.1">
        <property type="protein sequence ID" value="ENSMZEP00005033941.1"/>
        <property type="gene ID" value="ENSMZEG00005025381.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158391"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF1">
        <property type="entry name" value="ACIDIC AMINO ACID DECARBOXYLASE GADL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="464" mass="52125" checksum="649D27C81CB65A75" modified="2019-02-13" version="1">IIDNIPLNGPTVNVLASENFIHQSMSIIVENAIKKATDVREKVCEWRSPEQLKELLDLELRDGGESESEILQRFKDAIRYSVKTTHPHFFNQLYAGMEPYSMVASFIIEALKPSLYTYEVAPVFTLAEEAVLKKMMELIGWKDGGDGIFNAGGSMSNMYAVNLARYRCCPDIKENGLSAAPRLVMFTSQECHYSISKAAALLGIGTKNVYAIPSDERGKMIPSALEEQILSAKSEGAVPFMVNATAGTTVLGAFDPIDVIADICEKHNLWLHVDACWGGAALVSSKHKHLLKGIHRADSVAWNPHKMLMACLQCSAFMVRDKTSLLQRCHSARASYLFQQDKFYDVSYDTGDKSVQCSRKPDAFKIWLMWKALGSKELEQRVDRALAMARYLAEEIKKREGFRLLMEVAPVIKERMMKKGSMMVGYQPHGEKANFFRMIIISPQVSRQDMDFVLDEINNLGKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJX9</accession>
    <name>A0A3P9DJX9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJX9"/>
    <dbReference type="Ensembl" id="ENSMZET00005036311.1">
        <property type="protein sequence ID" value="ENSMZEP00005035065.1"/>
        <property type="gene ID" value="ENSMZEG00005026219.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286931"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27431" checksum="F3ED483B929ACE8C" modified="2019-02-13" version="1">MNQMDQTKICCSVCLELLKDPVTIPCGHSYCMNCIKSFWDEEEKKKIYSCPQCRQTFTARPVLVKNTMLADLVEELKKTGLKAAPADHCYAGPEDVACDFCTGRKMKAFKSCLVCLASYCEKHLQPHYDVAPLKKHKLVEPSKKLQENICSRHDEVMKMFCRTDQQSICYLCPVDEHKGHDTVSAAAERTERQRELEVSRQNIQQRIQDREKDVKLLQQEVESYSDHPDRFTVWCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK95</accession>
    <name>A0A3P9DK95_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MHC class II beta chain N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DK95"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034581"/>
    <dbReference type="Ensembl" id="ENSMZET00005035794.1">
        <property type="protein sequence ID" value="ENSMZEP00005034581.1"/>
        <property type="gene ID" value="ENSMZEG00005025830.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183127"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000353">
        <property type="entry name" value="MHC_II_b_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF99">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1 BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00969">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00921">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="MHC class II beta chain N-terminal" evidence="5">
        <location>
            <begin position="42"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="301" mass="34187" checksum="8E30FF22AD607EC6" modified="2019-02-13" version="1">DARRLLNGLRCITDYKKENTAVSSPQRLSQTSSTTSTLVLLSRCDFNSTELKDIRFTDSYYYNMIEIIRFDSNVGTFVGFTDFGVKTAEAWNNIPARLATMRAQKGTYCKPNIDVRYHNLMSKSAVQSVCQPPVTPPPTVKLHSTTPLSSHHPAMLVCSVYDFFPEVTSDVTSTEEMEDGDWYYQTTATGVHTQISCVVEHASLEKPLITNWGKYLSVSTHLTALCLILSLAGFIYYRQRARGQRTTLTHRPVHTRNQFRPETSSDQTEPFRDTKSQTTYDGSKTGFDQVYINIFFNILMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMQ4</accession>
    <name>A0A3P9DMQ4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein NDRG3</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMQ4"/>
    <dbReference type="Ensembl" id="ENSMZET00005037353.1">
        <property type="protein sequence ID" value="ENSMZEP00005036080.1"/>
        <property type="gene ID" value="ENSMZEG00005026923.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182872"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000006">
        <property type="entry name" value="NDRG family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="323" mass="35186" checksum="4F847F7673986D6F" modified="2019-02-13" version="1">MRGAAKGNRPTILTYHDIGLNHKSCFNSLFNFEDMQEVTQHFSVLHVDAPGQQENAPIFPTGYQYPSMDELAEMLPSVMTQLHIKSVIGIGVGAGAYVLTKLALNEPSLVEGLVLINVDPCAKGWIDWAASKLSGWTSNLVDIIMGHHFSTDELTENKEIIQTYRLHISQDIPQDNLAMFYNSYSSRAELQMERPVSGLNENTATTVRCPTLLVVGDSSPAVDVVVECNSRMNPTKTTLLKMADCGGLPQVVQPGKLAEAFKYFVQGMGYMPTAGMTRLVRSRTHSASSVGSTDGVRSRSTTNEGANCAEPDNTAVHTVEMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DN75</accession>
    <name>A0A3P9DN75_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DN75"/>
    <dbReference type="Ensembl" id="ENSMZET00005036996.1">
        <property type="protein sequence ID" value="ENSMZEP00005035733.1"/>
        <property type="gene ID" value="ENSMZEG00005026690.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044904"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="288"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="535" mass="61989" checksum="E2109319FC222164" modified="2019-02-13" version="1">PNWKLVPQKRGLKPEGPPAVYQLRAKKQNIGTLTKVTVGEKNLYKTNKTILLVSETGAGKSTLINALLNYTMGVKWEDKVWFEIVEDERRSQSESQTSDVIVYEIFGFEGKTLPYSLTIIDTPGYGGTKGIERDVIISQRLFDLFSSDDGVHEISAVGLVVKASVNRLSQRLMYIYDSVMSLFGKNMEKKIVAMITHSDGSRPKDVLLTLEAANIKCAKNEKNQPVYFLFDNQQHEERLEEKTFFKHSWELTQKNINHFTDFLEKSSPQTLMTTVEVLKERIRLTACIQNLQERIKLAELKQTQIRQIQEALKKLEAEMKRNERFTVEVHEVYKAKEPIDGGLRLFLFYEAAVCCTVCEENCHYPGCTMGWIPEHCEVMKGGRCTVCSRKCLASDHVKEKWRYVIKTRRVMKTNEEMKKQYEKNKMESKKMLSLLESLGMEMNQLIVEKSKFLDESYQHVIRLEQIALKADSASTIVHLDFLSEKMKEKRDTEKVQKLEEMRSRVDEGTREAYWYKLAERSSAIKNIGRSFPWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNG3</accession>
    <name>A0A3P9DNG3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUEL-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNG3"/>
    <dbReference type="Ensembl" id="ENSMZET00005037250.1">
        <property type="protein sequence ID" value="ENSMZEP00005035984.1"/>
        <property type="gene ID" value="ENSMZEG00005026850.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154285"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018014622" description="SUEL-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="115"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="202"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="310" mass="34606" checksum="735DD3990BE139A3" modified="2019-02-13" version="1">MLFFLLYWIIKISPWLQFDSMNSSSDEGQVIVVSWAYYGRRDTTTCSDGRPVSQIQNVNCFWPGSMDYVTTSCNGKNSCTVEAKSSEDPCYGIYKYLEWIHLIELQTWLQFMNSSSGEGQVIVVSWVNYGRRDNTTCSHGRPVSQIQNVHCSSPSSAEYVTNRCNWQNNCTVGASNTVFGDPCGGTYKYLEVVYDCQVHNVTCEGSQANLQCGQVIVVSWANYGRRDNTTCPDGNPDHSSADSPLTCIHRCNRQNNCTVGASNTGFGDPCSGTYKYLEVFYTCQGKNLKPLDCIHSCAHKKVIAEKDSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ48</accession>
    <name>A0A3P9DQ48_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MOV10</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Probable RNA helicase. Required for RNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ48"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036398"/>
    <dbReference type="Ensembl" id="ENSMZET00005037676.1">
        <property type="protein sequence ID" value="ENSMZEP00005036398.1"/>
        <property type="gene ID" value="ENSMZEG00005027164.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156024"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000608">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001941">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049077">
        <property type="entry name" value="MOV-10_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049075">
        <property type="entry name" value="MOV-10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21633">
        <property type="entry name" value="MOV-10_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21632">
        <property type="entry name" value="MOV-10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase MOV-10 N-terminal" evidence="16">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase MOV-10 Ig-like" evidence="17">
        <location>
            <begin position="140"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase MOV-10 helical" evidence="19">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="18">
        <location>
            <begin position="381"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="14">
        <location>
            <begin position="516"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="14">
        <location>
            <begin position="626"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="15">
        <location>
            <begin position="709"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1002" mass="114142" checksum="56B7FDCAECBDEFCC" modified="2019-02-13" version="1">MVNVKLSIRCQIGLEFFEFLKETNRVSITDRIQLRDIYNNEFRMRNPEAKDPNFGSVLYALKVSNKITRRRDTIRFNSKVKALYVDQWQWQRDRKPTPAQNGAASPGMGQTGASADEAETGVRYRRKTASLLMNKLKSERTHFISDKNGISITSERSFENGKLHLRVEETFESEITLHVKNTGTETVYFTYYTPLHWLKCLSLVDDQKVTKQNPLTLKPGDSYKIQAVFRFSLVGFYPATLAFEFKPDLQPSSAAFYIVRFIEAECVTSLGLELAPTAPYKPRSIPAWTPEVDCMTVEGVPPEGLALIHLKYVVKLKEYRVPSYIRNLLTSLKYSSFNAKRAILESPLNWENYTERFQVLLYLEELQMEVDIKRYNIPNTDRGHATMTKDKTNKKLLVLEVPGVAENRPSVLRGDKLLVYPVGEPGVKYCGYVHSVHLDSVKLGFSSQLVSRFVEGMKFSVEFTITRLTLRLQHRAAELASSYRLESVLFPAEPNMSFQPKDLPNLRLFDRQLEKNPEQYQAVQHIVAGSSKPAPYLIFGPPGTGKTVTVVEAIKQIEKTQANCYILACTPTNSAADLLCKRILEHVDKRKVYRMYASSWDPKLVPDELMECSNLVGECYIFPAKEELMTYKIMVTTLFTAGRFVSGDIPAEHFTHVFIDEAGHAVETECIIPLAGLLDATAGQVVLAGDPKQLGPILRSPYALKYGMGVSLLERLMNNFSVYQKNADGVFSKRFVTKLLRNYRSHPAILKIPNELFYDGELQACADEYARNFYCNWEELPKKNFPVIFHGVTGIDKREASSPSFFNVAEVEVLMDYVRKLLQAQGKKGVAKIAPRDIGIIAPYRKQVQKIRKALEKIGLEKEFQFMSMENLKVGSVEEFQGQERRVILVSTVRSSPDYTEMDKKFNLGFVKNEKRFNVAVTRAKALLIVVGNPRILETDSTWARFIQYCRDEGGYTGFTRAEEDVDVFARLQALYISIEPTVETAESVIQQQLDPEWRNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQY5</accession>
    <name>A0A3P9DQY5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testis expressed 36</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQY5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036854"/>
    <dbReference type="Ensembl" id="ENSMZET00005038143.1">
        <property type="protein sequence ID" value="ENSMZEP00005036854.1"/>
        <property type="gene ID" value="ENSMZEG00005027465.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175884"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029369">
        <property type="entry name" value="HDNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35440">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35440:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15115">
        <property type="entry name" value="HDNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function with conserved HDNR motif" evidence="1">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="124" mass="14111" checksum="98B6E4ED9D938842" modified="2019-02-13" version="1">KSREYPFSDHDNKHALKDDVIVFSHSVGRRKCLDDRRQHISRFCLCHGGTDNSTKETRGNATAYQSDFIVKEVVDSASRNRRFPHNHRQKSAEAALAQAGETFMWFGRDDSDQSDTLQVLAATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS85</accession>
    <name>A0A3P9DS85_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acyltransferase PGAP2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Post-GPI attachment to proteins factor 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the second step of the fatty acid remodeling, by reacylating a lyso-GPI intermediate at sn-2 of inositol phosphate by a saturated chain. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGAP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS85"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037314"/>
    <dbReference type="Ensembl" id="ENSMZET00005038618.1">
        <property type="protein sequence ID" value="ENSMZEP00005037314.1"/>
        <property type="gene ID" value="ENSMZEG00005027811.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047299"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF11">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="259" mass="29546" checksum="9D56463590F3003C" modified="2019-02-13" version="1">MLQGPYSSLDRDRLLIRLPFKSFAVGTVLLPVTGFIACIFISLWYHYEDATYTHCKVSNYLPSISSAISGVPERYIWRGCIGLHSAPRYLVAFAYFSFYRSRFANRLRELLLSGLALLCSLAENTGLVMLTYVSSTETYSVHKYGFITFIGSSLVHMLTTCWLWYVIKRHYVNPEEVTSYRWKLRLFLFNISCFVIAAYFFRRHNKYCEAGSKCRSALCCCPPCLTPSPCLTPSPSLLQSTPCSPPSSTWWSSPTWPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSM6</accession>
    <name>A0A3P9DSM6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSM6"/>
    <dbReference type="Ensembl" id="ENSMZET00005038434.1">
        <property type="protein sequence ID" value="ENSMZEP00005037136.1"/>
        <property type="gene ID" value="ENSMZEG00005027669.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176877"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="113" mass="12840" checksum="CAAC430C4A8AB7CE" modified="2019-02-13" version="1">MVRTCCAVGCKVRSHDRQGNKVENGLSFHSFPTWKQHEAAHVSDVTKRRRLVWIAAVRPADIQLSSISKYLLVCSRHFHSGKKWLPAPTSHNNPTLSHLHCCLRNLSVFVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DT53</accession>
    <name>A0A3P9DT53_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DT53"/>
    <dbReference type="Ensembl" id="ENSMZET00005038764.1">
        <property type="protein sequence ID" value="ENSMZEP00005037458.1"/>
        <property type="gene ID" value="ENSMZEG00005027935.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286952"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000774">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="335" mass="38000" checksum="3C1F3944288B5047" modified="2019-02-13" version="1">MRLLLKEETNKCMVTSTHEEPEPSSDFLSNNCPQPEWSQGQEESEHVHSGSTTNANTKRRNQRNRKSVKCEICGKTFQYKYRLLNHLRVHTGEKPYCCSTCGKGFRHLIHLKSHMRIHTGEKPYICSTCGKGFRHSSSSRVHMRIHTGEKPYSCSTCGKRFIQINSLNTHIRTHTGEKPHSCSACGKSFSNASAFRVHMRIHTGEKPHLCKVCGKTFSQAAHLKKHMRIHTGEKPHSCSACGKSFSNASAFRVHMRIHTGEKPHLCKICGKTFSQAPNLKKHMRIHTGEKPHSCSACGKSFSNASAFRVHMRIHTGEKPHFHHLLEPNSFLIFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTA0</accession>
    <name>A0A3P9DTA0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTA0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037356"/>
    <dbReference type="Ensembl" id="ENSMZET00005038662.1">
        <property type="protein sequence ID" value="ENSMZEP00005037356.1"/>
        <property type="gene ID" value="ENSMZEG00005027842.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271858"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF188">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="257" mass="28997" checksum="AC6D84D131754180" modified="2019-02-13" version="1">MPSMLVASWEHEDKQSRDPLRIVLIGKTGSGKSSTGNAILGRKVFEAKAIQMSLTKHCQKAHAEVDGRPVAVVDTPGLFDSTLSHDEVHKELVKCISLLAPGPHVFLLVMQIGRCTPEEKATLELIKKFFGKNSEKFTIFLFTGGDTLEHEEECDDSFKKLIADCGGRYHVFENSETQNRQQVSELMTKIDTMMKESGGNCFTNAMLQDAEAAIKKEMQRILKDKEEEMKRQREDLERKHEEEMKRSWCLGGYSIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARA7</accession>
    <name>A0A3P9ARA7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Olfactory receptor 52D1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARA7"/>
    <dbReference type="Ensembl" id="ENSMZET00005000250.1">
        <property type="protein sequence ID" value="ENSMZEP00005000195.1"/>
        <property type="gene ID" value="ENSMZEG00005000202.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183023"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000024">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052921">
        <property type="entry name" value="GPCR1_Superfamily_Member"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF871">
        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="39"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="319" mass="36665" checksum="3338631880377878" modified="2019-02-13" version="1">MNNVSVITMFFLSGFNETVSHRFVLFFLSLLCYCIICLVNVSLIVIIILDSNLHESMYILLCVFCINALYGTAGFYPRFLWDLLSDVHLISYYGCLIQTKVIYSFVCGELSILALMAYDRYVAICQPLKYHSIMTKQRVIRFACFLWFTTFCIVAVNAFLTSRLKLCSPYISTLFCVNWIIVQLACFPAQTAINAISANITIIIYLLHGVFIVWSYMYIIQTCVKSIENRAKFMQTCVPHLVSLFTFVVAILTDIISMRLGSKELPQSLQNFVALEFLVIPPIMNPLIYGFKLTKIRKRFYSVKGCKFHCLSSHYCSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARZ3</accession>
    <name>A0A3P9ARZ3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARZ3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000441"/>
    <dbReference type="Ensembl" id="ENSMZET00005000502.1">
        <property type="protein sequence ID" value="ENSMZEP00005000441.1"/>
        <property type="gene ID" value="ENSMZEG00005000438.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158371"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060856">
        <property type="term" value="P:establishment of blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000003">
        <property type="entry name" value="SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000001">
        <property type="entry name" value="Testican-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF17">
        <property type="entry name" value="TESTICAN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018208871" evidence="12">
        <location>
            <begin position="22"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="14">
        <location>
            <begin position="141"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="13">
        <location>
            <begin position="324"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="362"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="455" mass="51034" checksum="6A86A525BBB1CC88" modified="2019-02-13" version="1">MFFFLLPVVALLLSRETVVSANNNEKWLGTVAQYKDRSWNRFRDDDYFKSWAPAKSLDQERVAEPGRYGDPRTKAHSSSAKKTVQDGPDATKDPCLKVHCPPHKICVSHDYQTAICTNHKQPGHSVKPRKGSAGHKHRLEAGAHGKCRLCSALQSTPVCGSDGHTYSSECKLEFQSCLSGKKISVKCDGLCPCLPSQELSKPLHNGEKAACTDTELHSLSARLKDWFGVLHLDANRDLKSSDSFDSTTGHFDTSILPICKDSLGWMFNKLDMNFDLLLDQSELSAIYLDKYELCMKPLFNSCDSFKDGKLSNNEWCYCFQKPDGLPCQTEKSRIQSQSRRKSLIGTYIPRCTDEGYFKPTQCHGSTGQCWCVDKYGNEIAGSRKQGNPNCDEDQETSGDFGSGGAVILLDDQEEEPSQTGRSRQKKRRGRIHPRGTIEDDEDEEEDKDDEIGYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AS71</accession>
    <name>A0A3P9AS71_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zgc:194209</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570058.2">
        <property type="nucleotide sequence ID" value="XM_004570001.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AS71"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000463"/>
    <dbReference type="Ensembl" id="ENSMZET00005000524.1">
        <property type="protein sequence ID" value="ENSMZEP00005000463.1"/>
        <property type="gene ID" value="ENSMZEG00005000418.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101467670"/>
    <dbReference type="GeneTree" id="ENSGT00440000039984"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000032">
        <property type="entry name" value="Protein STRICTOSIDINE SYNTHASE-LIKE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF20">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018063676" evidence="4">
        <location>
            <begin position="27"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="5">
        <location>
            <begin position="166"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="382" mass="42298" checksum="12555DA883663739" modified="2019-02-13" version="1">MGRRSLLVALLAVAVGVYLLPSPIDPKPHVLKGPPPALEGPLAVNTRLQKGRRLFTGKLHGPESFTADEHGNVYTGTVDGKLWRIGPDDSLTFITHMGQNLPECGSSTDYEPVCGRPHGIRLDRHGQLIVADSYFGLHSVDPKTGEKTLLLANSEGADGVPFTFLNGLEISSQTGIIYFTDSSSRWGRRHVKLEVIELNSLGRLLSYNPQSGSVTVLLDSLYMPNGIVLSPDEDFLLLAETSIGRILRYWLKGPKSGTKEVIMDNMIGYPDNIRLSDHGTFLVGITTPRFRKFMPPFLDMIAPYPVIKRFLAKVVPLNWYNILLPRYALVLELGLDGELMGTLHDPEGRLTWAISDVFQHRGRTYLGSTDLPFLPILEGWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASG5</accession>
    <name>A0A3P9ASG5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASG5"/>
    <dbReference type="Ensembl" id="ENSMZET00005000699.1">
        <property type="protein sequence ID" value="ENSMZEP00005000626.1"/>
        <property type="gene ID" value="ENSMZEG00005000551.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234589"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002403">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018312677" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="239" mass="25992" checksum="0D8B36F716786268" modified="2019-02-13" version="1">MTLICVLIWTLLCCCFTGKSRGQITVTQPGAVSSAVGGTVSIKCRTSQDVYNNNHLAWYQQKDGGVPKLLIYAASNRQSGIPARFTGSGSNSDFTLTISGVQAEDAAVYYCQSFHYPNSQRFVSLWYTFGGGTRLDVGRNVAPSSEELQQGTATITCLANKGFPSDWSLSWKVDGSGSISWEESRSPVVLQNDGLYSWSSTLRLPADRWMKVGSVTCEATQGCQALVSEPLRRDQCPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASK8</accession>
    <name>A0A3P9ASK8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASK8"/>
    <dbReference type="Ensembl" id="ENSMZET00005000777.1">
        <property type="protein sequence ID" value="ENSMZEP00005000705.1"/>
        <property type="gene ID" value="ENSMZEG00005000635.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234896"/>
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        <property type="component" value="LG22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="179" mass="20036" checksum="28612AFF3E23CD65" modified="2019-02-13" version="1">VMEPTGPVDGDVCLLLVQLHCSKLTKLEETIKDWTVLSNIDCKKEKTKNSALTSLHLFAVLRHVVRSDGPQELNVIITVVLCHLFTTDLHFSVQSIVEEEVVRHTDPVWFHGMALAIVVIPHITCGQKHHPDKFILDIAKKKKERKKSHIALGILVLLKMPNSSSAQPKTCSSAFQIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATV5</accession>
    <name>A0A3P9ATV5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004572667.1">
        <property type="nucleotide sequence ID" value="XM_004572610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATV5"/>
    <dbReference type="Ensembl" id="ENSMZET00005001222.1">
        <property type="protein sequence ID" value="ENSMZEP00005001134.1"/>
        <property type="gene ID" value="ENSMZEG00005000977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476127"/>
    <dbReference type="KEGG" id="mze:101476127"/>
    <dbReference type="GeneTree" id="ENSGT00950000183048"/>
    <dbReference type="OrthoDB" id="8390270at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000024">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052921">
        <property type="entry name" value="GPCR1_Superfamily_Member"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF885">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="39"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="308" mass="35290" checksum="9D992AB4EFE36D39" modified="2019-02-13" version="1">MTNLSQVSYFTFSAYFDTGPFKYLYFTIVMSLYVFIFGSNLLLIVVICVNRSLHEPMYMFLCSLFVNELYGSTGLFPFLLLQILSDVHTVSAPLCFLQIFCLYTYANVEFYNLAIMSYDRYLAICCPLQYHTHMTFNKVAKLIVLTWLFPILNIVVMISLNASLQLCGHTVDTLYCNNYSVVKLACFDTTINNIYGLMYTFTVLIGLALLNLFTYVKILKVCFSGSKQTRQKAVSTCTPHLASLLNFSFGCFFEIVQSRFNLSRAPMILRIFLSIYFLTCQPAFNPVLYGLKLTKIRLICKSLLFGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUU3</accession>
    <name>A0A3P9AUU3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanylate cyclase activator 2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the guanylin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_023010831.1">
        <property type="nucleotide sequence ID" value="XM_023155063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUU3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001490"/>
    <dbReference type="Ensembl" id="ENSMZET00005001579.1">
        <property type="protein sequence ID" value="ENSMZEP00005001490.1"/>
        <property type="gene ID" value="ENSMZEG00005001222.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:111501527"/>
    <dbReference type="GeneTree" id="ENSGT01010000222588"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030250">
        <property type="term" value="F:guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1450.10">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000879">
        <property type="entry name" value="Guanylin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036382">
        <property type="entry name" value="Guanylin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11318:SF4">
        <property type="entry name" value="GUANYLATE CYCLASE ACTIVATOR 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11318">
        <property type="entry name" value="GUANYLIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02058">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001849">
        <property type="entry name" value="Guanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00774">
        <property type="entry name" value="GUANYLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89890">
        <property type="entry name" value="Proguanylin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018123173" description="Guanylate cyclase activator 2B" evidence="9">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="93"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="96"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001849-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="106" mass="11607" checksum="6A44CE2E0D3F963D" modified="2019-02-13" version="1">MRVLFALFLVGCVCGVPQGLWVRVGDKSFPLEAVKQLKKIMELDENLGSHSDAHTFKTVCANPLVPQVFRPVCQKDEEVAVFSSLMVINMNECEICANPACAGCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVY1</accession>
    <name>A0A3P9AVY1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVY1"/>
    <dbReference type="Ensembl" id="ENSMZET00005001960.1">
        <property type="protein sequence ID" value="ENSMZEP00005001865.1"/>
        <property type="gene ID" value="ENSMZEG00005001514.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234589"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001918">
        <property type="entry name" value="Immunoglobulin light 1 constant 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="51"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="153" mass="16774" checksum="3F87E0FBF304845C" modified="2019-02-13" version="1">MILLSLFVSESESRVSLQSEVFVRCLNEFVSLWWTFGGGTRLDVNLGRVPPSLTVLAPSSEELQQGKATVMCVANKGFPSDWRLSWKVDGRSSSGEESRSPGALQNDGHYSWSSTLRLPADQWEKVGSVTCEATQGSHTPLSETLMTDQCSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWX8</accession>
    <name>A0A3P9AWX8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Microsomal glutathione S-transferase 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_014266950.1">
        <property type="nucleotide sequence ID" value="XM_014411464.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWX8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001927"/>
    <dbReference type="Ensembl" id="ENSMZET00005002024.1">
        <property type="protein sequence ID" value="ENSMZEP00005001927.1"/>
        <property type="gene ID" value="ENSMZEG00005001565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474131"/>
    <dbReference type="KEGG" id="mze:101474131"/>
    <dbReference type="CTD" id="4258"/>
    <dbReference type="GeneTree" id="ENSGT00940000160288"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019370">
        <property type="term" value="P:leukotriene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000003">
        <property type="entry name" value="Leukotriene C4 synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001446">
        <property type="entry name" value="5_LipOase_AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF13">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00488">
        <property type="entry name" value="5LPOXGNASEAP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0434">Leukotriene biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="138" mass="15356" checksum="EEC5C418E52F57CD" modified="2019-02-13" version="1">MEADSPLLLAAVSLLSVLHMGYLARRVGRSRMAYNIVPPVVTGPPEFERTFRAHQNCVEFYPLFLVSMWTCGTFFSEVIAAAGGLVYMVARQMYFSGYITSPKKRLPGFILNLVVLGILSLLGSIGVLRGILYKYFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AX02</accession>
    <name>A0A3P9AX02_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Amyloid protein-binding protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Amyloid beta precursor protein-binding protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of a CRL2 E3 ubiquitin-protein ligase complex, also named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter APPBP2. Interacts with APP; APP interaction inhibits the E3 ubiquitin-protein ligase activity of the CRL2(APPBP2) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_024660640.1">
        <property type="nucleotide sequence ID" value="XM_024804872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AX02"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002164"/>
    <dbReference type="Ensembl" id="ENSMZET00005002265.1">
        <property type="protein sequence ID" value="ENSMZEP00005002164.1"/>
        <property type="gene ID" value="ENSMZEG00005001710.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105940701"/>
    <dbReference type="KEGG" id="mze:105940701"/>
    <dbReference type="CTD" id="10513"/>
    <dbReference type="GeneTree" id="ENSGT00390000010722"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000177">
        <property type="entry name" value="Amyloid beta precursor protein binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000152">
        <property type="entry name" value="Amyloid protein-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042476">
        <property type="entry name" value="APPBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46575:SF1">
        <property type="entry name" value="AMYLOID PROTEIN-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 19" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="19">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="588" mass="67184" checksum="2093DC8493E8672E" modified="2019-02-13" version="1">MAAVELEWIPETLYNTAISAVVDNYSRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGGEFCELEVFAKVLRASDKRHLLHHCFQALMDHGVKVASVLANSFSRRCSYIAESDAHVKEKAIQFGFVLGGFLSDAGWYGDAEKVFLSCLQLCTLHSEVLHCYRAVECCVRLLHVRNGNCKYHLGEETFKLAQSYMDKLAKHGHQANKAALYGELCALLFAKSHYDEAYRWCIEAMKEITPGLPVKVVVDVLRQASKACVVKREFRKAEQLIKHAVFLAREHFGHKHPKYSDTLLDYGFYLLNVDNICQSVAIYQTALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIDIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEERLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGHEDYEVALSVGHLASLYNYDMNQYEDAERLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSVGNYEKVFEYHNVLSNWNRLRDRQFAVADALEDVNTTPQQTQEVVQAFLLAQSLGPTRPCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AX04</accession>
    <name>A0A3P9AX04_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myomesin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Myomesin family member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005002230"/>
    <dbReference type="Ensembl" id="ENSMZET00005002331.1">
        <property type="protein sequence ID" value="ENSMZEP00005002230.1"/>
        <property type="gene ID" value="ENSMZEG00005001720.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154982"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20951">
        <property type="entry name" value="IgI_titin_I1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000069">
        <property type="entry name" value="Alpha-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000029">
        <property type="entry name" value="Myomesin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000124">
        <property type="entry name" value="Myomesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000134">
        <property type="entry name" value="Myomesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000192">
        <property type="entry name" value="Myomesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000197">
        <property type="entry name" value="Myomesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000222">
        <property type="entry name" value="Myomesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000467">
        <property type="entry name" value="Myomesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002172">
        <property type="entry name" value="Myomesin 1a (skelemin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000179">
        <property type="entry name" value="Myomesin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF16">
        <property type="entry name" value="MYOMESIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="150"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="280"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="374"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="502"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="603"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="702"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="807"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="900"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1334"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1424" mass="159081" checksum="62A6D97AE2FB5AA0" modified="2019-02-13" version="1">MSGSIPFYQKHHLHYDRGYRSKETQSKVSQYQASSRYSASGSASANWKSKIAFQQPKVLTTCLAFTSIPGSALLPPSQEFATGLSDTEEARVRDTAAYMARRDLFTSGLEMERSELISRKETMRESAERITLNKREHFKRMNEDSLMHAPEFVIKPRSHTVWEKQCVRLHCTVSGWPDPRVVWYKNNVALDPLANPGKYKIESRYSVHSLEINKCDFDDTAQYRVSAMNSQGELSAFASVVVKTSDFVVTSFCIVGPVSEYGITFQTHIVDKFGVSFGREGETMSLGCTVIIYPALHRYQPEVEWYRDDVLLSPSKWTHMHWSGDRATLTLTHLNKEDEGLYTLRVTTKSGYETYSAYVFVRDADAEVEGAPAAPLDVRCLDANKDYIIVAWKQPAVDGGNSILGYFVDRCEVGTTHWIQCNDTPVKFARFPVTGLVEGRSYIFRVRAVNKSGISRPSRVSEPVAAMDPADRARMRGSTSAPWTGQIIVTEEEPAEGIVPSKPCDLQVTEATKNYVVLSWKPPGEKGLEGVMYYVEKCVSGTDSWQRVNTEIPVKSPRFALFDLAEGKAYRFRVRCCNSAGVGEPSDPTEATTVGDKLDIPSAPGKVIPTRNTDTSVVVSWEASCNAKELVGYYIEGSIVGSNVWEPCNNKPVNVTRFICHGLITGEKYVFRVRAVNAAGISQFSQESEAVEVKAAIASPAPPYGITILECVRDSMVLAWKQPTFIGGADITGYFVDYREVIDGVPGKWHEANIKAVSERAYRVSDLKENKKYQFQVRAANMAGVGIPSLPSNTFLCEEWTIAVPGPPHDLQIREARNDSLVLLWKPPVYQGRDPVNGFYVDIKEADAPEEAWRGVNTKALEKTYTKIKDLKEGEKYVFRVRAQNKAGVGKVSDVTEPVPALTKPGTKEIVVDVDDDGVISLNFECGNMTPDSKFVWSKNYEDITDTSRLTTETKGTKSKVVFNRPGEEDIGVYSCLVTHTDGASSSYTLSEEELKRLLEISHDHKFPIIPLKSDLAVELLEKGRVRFWLQAEKMSNNGKVDYVFNDNVVSQGEKYKMNFDKNTGVIEMTMESLTPADEGTYTFQLQDGKATNQSSLVLIGDVFKQLQKESEFQRKEYFRKQGPHFIEYLSWEVTPECCVVLKCKVGNMKKETSALWHKDRHQIKVDEHLGFAEGVLKLEIAQISKKDAGVYEVILKDDRGQDTSTLNLTDQGFKDLMNEVFSVIANSSTPLKITSTDEGIRLYTFVSYYNDLLQVTWHYKDSAIAFSDRIKSGVVGEQLWLQITEPTEKDMGKYAIEFYDGKGGLRRTVDLSGQGECLNRARVAGGLPDVVTIQEGKALNLTCNISGNPVPEVTWLKNDREITSDEHCILKFESGKFASFTITGVNTSDSGKYSILVKNKYGTESGDFTVSVFIPEEAGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXJ6</accession>
    <name>A0A3P9AXJ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="18">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="18"/>
    <dbReference type="RefSeq" id="XP_004540385.1">
        <property type="nucleotide sequence ID" value="XM_004540328.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXJ6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002373"/>
    <dbReference type="Ensembl" id="ENSMZET00005002481.1">
        <property type="protein sequence ID" value="ENSMZEP00005002373.1"/>
        <property type="gene ID" value="ENSMZEG00005001875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474799"/>
    <dbReference type="KEGG" id="mze:101474799"/>
    <dbReference type="GeneTree" id="ENSGT00940000155462"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060027">
        <property type="term" value="P:convergent extension involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031101">
        <property type="term" value="P:fin regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14203">
        <property type="entry name" value="PTKc_Src_Fyn_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12006">
        <property type="entry name" value="SH3_Fyn_Yrk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000553">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000016">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000001">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000182">
        <property type="entry name" value="Tyrosine-protein kinase Fyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035750">
        <property type="entry name" value="Fyn/Yrk_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="7 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 18" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="20">
        <location>
            <begin position="149"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="271"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="537" mass="60543" checksum="04391C218A1EB39D" modified="2019-02-13" version="1">MGCVQCKDKEAAKLTDDRETSLSHNSGYRYGSDPTPQHYPSFGVTTIPNYNNFHSAASQGVTVFGGVHTSSQSGTLRSRGGTGVTLFVALYDYEARTEDDLSFRKGERFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFGKLGRKDAERQLLSNSNARGTFLIRESETTKGAYSLSIQDWDDVKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSARAAGLCCRLIVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPSSLHELMLQCWKKDPEERPTFEYLQAFLEDYFTATEPQYQPGDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZW7</accession>
    <name>A0A3P9AZW7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TBC1 domain family member 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with RAB1A and RAB10; in a GTP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004561942.1">
        <property type="nucleotide sequence ID" value="XM_004561885.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZW7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003211"/>
    <dbReference type="Ensembl" id="ENSMZET00005003340.1">
        <property type="protein sequence ID" value="ENSMZEP00005003211.1"/>
        <property type="gene ID" value="ENSMZEG00005002478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482347"/>
    <dbReference type="KEGG" id="mze:101482347"/>
    <dbReference type="CTD" id="54662"/>
    <dbReference type="GeneTree" id="ENSGT00940000158674"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000009">
        <property type="entry name" value="TBC1 domain family member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000019">
        <property type="entry name" value="TBC1 domain family member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="9">
        <location>
            <begin position="35"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="400" mass="46819" checksum="1F892CC02EEE3DDA" modified="2019-02-13" version="1">MSTAYKNRIQEFKVALAEEKINLKTLRELCFNGIPFEGGIRALCWKILLNYLPVDQTQWESFLKKQREVYSQFLKEMIIQPGIANANLGLSREDVTMEDHPLNPNPDSRWNTYFKDNEILLQIDKDVRRLYPDMAFFQRPTEYPCQLILDPQNDYETLRRRVEQTTLKAQTVNCNRSGVTNVSSPGKALNLYPSNEYEVLPNGSEAHWEVVERILFIYAKLNPGIAYVQGMNEIVGPIYYTFATDPNSEWKEHAEADTFFCFTNLMSENRDNFIKSLDDSQCGITYKMESVYSMLKDKDMELYLKLEEQNIKPQYFTFRWLTLLLSQEFLLPDVIRIWDTLFSDQDRFHFLILVCCAMLILIRDNLLAGDFTVNMRLLQDYPISDVHTILTKAKDLQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B087</accession>
    <name>A0A3P9B087_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">High affinity choline transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Hemicholinium-3-sensitive choline transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 5 member 7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">High-affinity Na(+)-coupled choline transmembrane symporter. Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry. Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion. Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release. SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials. Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>choline(out) + n Na(+)(out) = choline(in) + n Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:76443"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homooligomerizes at cell surface. Interacts with SEC14L1; may regulate SLC5A7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Presynaptic cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 19">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004543372.1">
        <property type="nucleotide sequence ID" value="XM_004543315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B087"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003338"/>
    <dbReference type="Ensembl" id="ENSMZET00005003470.1">
        <property type="protein sequence ID" value="ENSMZEP00005003338.1"/>
        <property type="gene ID" value="ENSMZEG00005002577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476378"/>
    <dbReference type="KEGG" id="mze:101476378"/>
    <dbReference type="CTD" id="100005589"/>
    <dbReference type="GeneTree" id="ENSGT00690000101915"/>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000008">
        <property type="entry name" value="High affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF2">
        <property type="entry name" value="HIGH AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="597" mass="65274" checksum="C780FF539EB70C8E" modified="2019-02-13" version="1">MTIHVEGLVAIAVFYLLILFVGIWAAWKNKHSGEAEGTDRSETIMVGGRDIGLFVGGFTMTATWVGGGYINGTAEYVYLPDYGLAWAQAPFGYALSLVLGGLFFAKPMRSRGYVTMLDPFQQLYGKRMGGLLFIPALMGEIFWSAAILSALGATLSVIVDINIKMSVVISALIAIFYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALINPAVSDITVTAVKHLYQSPWIGSVQKGDTWVWIDNFCLLMLGGIPWQVYFQRVLSASSATYAQVLSFLAAFGCLVMAVPSVLIGAIGASTDWNQTSYGAIPPKNKTEADMILPIVLQHLCPPFVSFFGLGAVSAAVMSSADSSILSASSMFARNIYQLAFRQSASDREIVWVMRITIFVFGGLATLMALVTGTVYGLWYLSSDLVYVIIFPQLLSVLFVKGTNTYGSVAAYLFGMVLRIGGGEPYLQLPPFIYYPGWMTEQRKHHITGELEEIVVQKFPFKTVSMLASFLGNVAVSYLAKYLFESGKISHKYDFLDAVVSKHSGEIMDKTTLVTRGNAIGLSEMAPMKPRLSVTLAAAFTRRDTLPTETVEEEEEESSPDSSHHEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0R1</accession>
    <name>A0A3P9B0R1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sperm associated antigen 17</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005003464"/>
    <dbReference type="Ensembl" id="ENSMZET00005003596.1">
        <property type="protein sequence ID" value="ENSMZEP00005003464.1"/>
        <property type="gene ID" value="ENSMZEG00005002614.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013693"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990716">
        <property type="term" value="C:axonemal central apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026173">
        <property type="entry name" value="SPAG17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963">
        <property type="entry name" value="PF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21963:SF1">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14874">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1437" mass="161753" checksum="7604F4575EFD02BC" modified="2019-02-13" version="1">MPPKGAKKGSAKKSSTDGGAANKNWETGLIKAEFEEDSWQACVSFVVGRGPQEEELIQALALAVQEPQRKLFTLLTWDDTLIHELGNPKAKKPDDAPMFYQVTEPAKLLLDAGEGIPCDLMAKILKFQLLLIKACYQQRSDAEEEKTTVSDKKGKGPHTPVIPPKEKKTKLKRRGDVEPPTFKDDEPEWGPQHYILILGFYQPQLIAGLDAIGVHVSNVIKLCLEFSQNMEEQQDHQDSCEGNEQSLRASPERKLNEFWSGLRSVLDSGPPDSRLHDVVQLSYTVPHFFQIFDGVASLIYDCLDVRRQYQQYRNNVKFISVPAVVKHSEPVEVNICRYKNRLLPLSLDVDMCYYNNLLDLVAPEACSVPLILHCMLEQVCVHLVVQDFDPTEVELSMMRLSPVWEMIESVTQQKNRKSCWMSIKQQLQHYCTDDDVSWPEVERFFHQSVLEAMPLSGVDQQGVLRGIADPAQQQTSIVIPWDDPLSFAKQQLYNMRNKACFNFKKKKTAMDPVFFPQEQSGRVCSHLDLPDIQSCRLRSLFHWRYAEHHNATLLQLASEEYCCLDTFRGSHNNILYVFCHNPMSPQRQSREFWHVALHTDVKFRCEMMLVTRGIVRNLLLIAFMDVHVCVIAMCWNRVLTPGFIKEPTLNYFRVTKVLHGYSIMVLQAWKLEQERQKEEAIPKKSKKEDLPKDKQQKKEDKSTDNKKKKTSSDDKKSRPGTEGSSANPPTESAITTAPPGFIGYIMDGKLIHVSGCLQYLFPSDGGRVTVETVSFVQGTGSVCVLHESKQTFNYKLTNSLLRQYRKLQTCDTSLSKELSRIITSQGAVIRYMRDGSTEVLFADGSVSFSQDSGPVWVPDSEVMLNREDLVVSVQNPDGSVVVEHADGTRITSLLQERPMNANPHCLLRTGDQQAHKRMVLVEKEGCATVVMYPERQTAHIFLADGTVVTGNNQREYEVFPSSVGVLSIRSDGTCVYSSDPLVTPSPKGSTPTEQTGIYTMSHMGKVACEITDPDGNHFQVSFSDHKIVSLCCCAVCKRILSSRLFLVHGDGSGTELLSSQTVKELLCQAYLDPTIALLKEQLFGITILKPSHQSVWSQWLLNKQNPEITPPNLRNRSWHDFPAVEKKSPGPPFGTDVVYNLGLRMRPAGSAVHHRPVRSCPKVLELRELYQHRPFTTPLKNTIDSRLKEYIESLMEREQRSEKMKVKDPRSEEETAHASDLINLILIVESLPGLDGSVQRQIILYMIYTSMQTYELSCVCLCACTRPGESSWRDSSRKCKSPQLDVSGKPRQTTVTLPSSVLGSKSCSAPVQNHFCFFAKNVLVEFLFWVGFQLIPSSVDFGTLKEGTSSTIIVVMKNVGFDICRFHVKQPPPATGLRVIYSPGPVAAGLQVELKVQLFAMCAVQAGEVEPKKLISQEIIIPTEKDILCLPVTANIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B173</accession>
    <name>A0A3P9B173_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glypican 5a</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B173"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003467"/>
    <dbReference type="Ensembl" id="ENSMZET00005003599.1">
        <property type="protein sequence ID" value="ENSMZEP00005003467.1"/>
        <property type="gene ID" value="ENSMZEG00005002681.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244955"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905475">
        <property type="term" value="P:regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001863">
        <property type="entry name" value="Glypican"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019803">
        <property type="entry name" value="Glypican_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10822:SF12">
        <property type="entry name" value="GLYPICAN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01153">
        <property type="entry name" value="Glypican"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01207">
        <property type="entry name" value="GLYPICAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 12" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="324" mass="35978" checksum="E6C1C71A2239BB2C" modified="2019-02-13" version="1">ESFEALLWQAENYTTTLFQDLYHSMADQAAGPVRELFTDISLFLLGSEFSVDELVQRFFDALFPLVYDHLISPSLSGVSLGHAECVRSLSRSVRPFGGVPGHLADQIARSGVSGKLLLQALHLGIEVINTTDHLQLSRECRRALLKMHYCPHCQGLTQSKPCMGYCINVMRGCLASMAEIDIHWREFVRSLEGLSARMHGPQDLEQVLLGIHRLVRDAVRHAQENGPRLLAQVYKLCGPPSRKPAQSVSIQHSSSRESIPLKASVRAPGGSLANRRKDFLSSLRLYLTYYGGLADQLCASDLASNDALSCWNGTEIVKRFVLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1A1</accession>
    <name>A0A3P9B1A1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B1A1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003715"/>
    <dbReference type="Ensembl" id="ENSMZET00005003868.1">
        <property type="protein sequence ID" value="ENSMZEP00005003715.1"/>
        <property type="gene ID" value="ENSMZEG00005002854.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153653"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000354">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000008">
        <property type="entry name" value="COP9 signalosome complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048621">
        <property type="entry name" value="CSN3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21215">
        <property type="entry name" value="CSN3-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="114"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="340" mass="38807" checksum="05B649A0B61106C0" modified="2019-02-13" version="1">MAKSSLCVGKHCKCIYPRSHKQQESHMTLLSNTPLRGVVVLKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPALPFLEVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYTTNNPAELRSLVNKHSETFTRDNNTGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIYASINQKDGMVCFHDNPEKYNNPAMLHKIDQEMLKCIQLDEKLKSMDQEITVNPQFVQKSMGSQEDDVGSKTSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1B4</accession>
    <name>A0A3P9B1B4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B1B4"/>
    <dbReference type="Ensembl" id="ENSMZET00005003878.1">
        <property type="protein sequence ID" value="ENSMZEP00005003725.1"/>
        <property type="gene ID" value="ENSMZEG00005002885.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000279829"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="142" mass="16946" checksum="577DF2A9ADAFA0FE" modified="2019-02-13" version="1">LPQPAGASFPVLSVFSSVVYPFLSHLRHFLSHLRHFLSHLRHFLSHLRHFLSRLRHFLSHLRHFLSRLRHFLSRLRHFLSRLRHFLSRLRHFLSRLRHFLSRLRHFLSNSSMKRSKTGKPSSMKCSMMLITSSRSFSNASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3E7</accession>
    <name>A0A3P9B3E7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Forkhead box B1</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004565814.1">
        <property type="nucleotide sequence ID" value="XM_004565757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3E7"/>
    <dbReference type="Ensembl" id="ENSMZET00005004606.1">
        <property type="protein sequence ID" value="ENSMZEP00005004404.1"/>
        <property type="gene ID" value="ENSMZEG00005003422.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477516"/>
    <dbReference type="KEGG" id="mze:101477516"/>
    <dbReference type="GeneTree" id="ENSGT00940000160522"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20043">
        <property type="entry name" value="FH_FOXB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000082">
        <property type="entry name" value="forkhead box protein B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047389">
        <property type="entry name" value="FOXB1_B2_FH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF377">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="307" mass="33417" checksum="55D8D0A944B6D40A" modified="2019-02-13" version="1">MPRPGRNTYSDQKPPYSYISLTAMAIQSCPEKMLPLSEIYKFIMDRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSFLRRRKRFKVGSMQAADPLAASKPQDAAHYLQQQAKLRLSALHAAAHLPQMPAGYNLSSVSQPSSFKHPFAIENIIAREYKMPGGLAAFSTAGYPLHNQLTPAWPHMYGSGMMETAAPISMAASDYSAYGMPLKTICHGGQTLPAIPVPIKPSPASVPGLPGLPAHIPAFLANSPQSLSPTSPQTATGQSSPGGPGEALQSAVAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3L3</accession>
    <name>A0A3P9B3L3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">trypsin</fullName>
            <ecNumber evidence="11">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="11"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3L3"/>
    <dbReference type="Ensembl" id="ENSMZET00005004671.1">
        <property type="protein sequence ID" value="ENSMZEP00005004469.1"/>
        <property type="gene ID" value="ENSMZEG00005003494.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244883"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000258">
        <property type="entry name" value="Anionic trypsin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000008">
        <property type="entry name" value="Cationic trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF6">
        <property type="entry name" value="TRYPSINOGEN 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0222">Digestion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017944502" description="trypsin" evidence="13">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="242" mass="26495" checksum="324AF1D8B530BED4" modified="2019-02-13" version="1">MRSLIFVLLIGAAFALEDDKIVGGFECTPYSEPHQVSLNSGYHFCGGSLINQNWIVSAAHCYESRIQVRLGEHDISVNEGTEQFIDSSRVIRHPQYDSWNIDNDIMLIQLSQPASLNSYVQPVALPRSCAPAGTMCTVSGWGNTMSSTADQDRLQCLNIPILSYSDCNNSYPGMITDSMFCAGYLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCAERDHPGVYTKVCIFNDWIQQTMASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B841</accession>
    <name>A0A3P9B841_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SLIT and NTRK like family member 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLITRK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552659.1">
        <property type="nucleotide sequence ID" value="XM_004552602.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B841"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005992"/>
    <dbReference type="Ensembl" id="ENSMZET00005006253.1">
        <property type="protein sequence ID" value="ENSMZEP00005005992.1"/>
        <property type="gene ID" value="ENSMZEG00005004635.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465371"/>
    <dbReference type="KEGG" id="mze:101465371"/>
    <dbReference type="CTD" id="114798"/>
    <dbReference type="GeneTree" id="ENSGT00940000159810"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000001">
        <property type="entry name" value="SLIT and NTRK-like family, member 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773:SF7">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018169482" evidence="11">
        <location>
            <begin position="18"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="12">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="12">
        <location>
            <begin position="534"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="255"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="701" mass="78154" checksum="775920BAA1EE3DD3" modified="2019-02-13" version="1">MLLWIVLLKAALCLASGNVTRDVCKEQICSCNEVEGDLHIDCEKRSFTTLQQLTGPSSQFYHLLLHGNSLSRLFPNEFANFYNAVSLHLENNGLHDIVPGAFLGLQLVKRLHINNNKIRSFRKSTFLGLDDLEYLQADFNLLRDIDPAVFRDLNKLEVLILNDNLISALPVNVFQHVPITHLDLRGNRIKTLPYEGILEQIPGIAEVLLEDNPWDCNCDLVSLKEWLENIPRNALIGRVICEAPTRLQGSDLNETSEADLCPSQSAGVDSSLVAPPTQEETSMARDTHPTPYKPSGNASRPPTPGGHGSNKNHSKSRENWQLKTKPTPVAAGVDREQQQLRNVTCPEPCKCKLVGSRQGLGVNCEGKKIENLSNLKPKPLAAHELNMRENNIHAVKKNQLLGYASLNLLDLGANNIKVIDNGTFQNQSELRWLYLDKNYLDALVTEMFVGLVNLEYLSLEYNDIQLVVAGAFSPMPNLRVLFLNNNLLKSLPADAFLGISLSKISLHNNYFPYLPVAGVLDQLNSIIQIDLHGNPWDCSCKIVPFKQWTEKLGADVIVSDLKCESPEEFWKRDFRYVRNDLLCPKLYVSPTSLSKNSTFAQDSGTRSNSYLEPNRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDGNSSASEINSLQTVCDSSYWHSGSYHADGGAHRGFDCSTHLSTTNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B876</accession>
    <name>A0A3P9B876_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B876"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006099"/>
    <dbReference type="Ensembl" id="ENSMZET00005006387.1">
        <property type="protein sequence ID" value="ENSMZEP00005006099.1"/>
        <property type="gene ID" value="ENSMZEG00005004064.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01110000267181"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="155" mass="17293" checksum="AFA286E8C01D1CF1" modified="2019-02-13" version="1">MPEPAKSAPKKGSKKAVTKTAGKGGKKKRKTRKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSKTPPTHTHTHENKVILHFHIHEDVCSERSVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9K4</accession>
    <name>A0A3P9B9K4_9CICH</name>
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        <submittedName>
            <fullName evidence="6">Prepronociceptin</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
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                <person name="Greuter L."/>
                <person name="Guyon R."/>
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                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the opioid neuropeptide precursor family.</text>
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        <property type="nucleotide sequence ID" value="XM_004539764.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9K4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006593"/>
    <dbReference type="Ensembl" id="ENSMZET00005006891.1">
        <property type="protein sequence ID" value="ENSMZEP00005006593.1"/>
        <property type="gene ID" value="ENSMZEG00005005091.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101473568"/>
    <dbReference type="CTD" id="100529086"/>
    <dbReference type="GeneTree" id="ENSGT00950000183149"/>
    <dbReference type="OrthoDB" id="9884757at2759"/>
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        <property type="component" value="LG1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:opioid receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chemical synaptic transmission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <location>
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    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BB61</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
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                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
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                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSMZET00005007443.1">
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        <property type="gene ID" value="ENSMZEG00005005488.1"/>
    </dbReference>
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        <property type="component" value="LG3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="137" mass="15101" checksum="B6479F400622AEB0" modified="2019-02-13" version="1">MLRQVVQVQPQSTVQEEGQWSTGLCECYKDMGDCCFALCCLPVFTCKVTSAVGACPCLPLLDCIGCVPPASLAMRASVRQERYAITACTTSFCGPCTWCQIARGSQMRKNTITFVNIEILAFKDCFLCLFISEKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BC29</accession>
    <name>A0A3P9BC29_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polynucleotide kinase 3'-phosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
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                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
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                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004562816.1">
        <property type="nucleotide sequence ID" value="XM_004562759.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BC29"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007448"/>
    <dbReference type="Ensembl" id="ENSMZET00005007759.1">
        <property type="protein sequence ID" value="ENSMZEP00005007448.1"/>
        <property type="gene ID" value="ENSMZEG00005005701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480033"/>
    <dbReference type="KEGG" id="mze:101480033"/>
    <dbReference type="CTD" id="11284"/>
    <dbReference type="GeneTree" id="ENSGT00940000159302"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041388">
        <property type="entry name" value="FHA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006550">
        <property type="entry name" value="PNKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01663">
        <property type="entry name" value="PNK-3'Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17913">
        <property type="entry name" value="FHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNK FHA" evidence="7">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="602" mass="66580" checksum="A41840493758901A" modified="2019-02-13" version="1">MSCTLVGASGARISLEDGRAVILGRDPDTGVTDKKCSRHQVKVVACFADQDVVVTQLGPNPSSLDGEKLGRGQSGKLSHGGTLYLVNQSHPFTLNYSLSSNGITSSTAQRGLKAADKTKGGTSSKEKEAQSSPTPKRNIKDFFPSSPMKSSKRQLSPKKEQPEVKRQRIEEEASDWQMKEEEDEEERLAGERLKYLQEFAKKSLTEESSSNQPSSSSKPSLKSSWQQFGSLMVYTAAGVKGSDKIAGFDIDGCIITTKSGKVFPTAPDDWKILYPEIQPKLASLLKKGYKVVFFTNQLGIAKGKLRPEVFKSKVEDILATLKLPVQVFVATGPGIYRKPVMGMWNHLCEKANDDVTVDMTQSFYVGDAAGRPENWAPGKKKKDFSCSDRLFALNIGLQFYTPEEYFLGWKRAPYNLPELNPTKLDSAARLYDPPSASLTSGDTEVIVAVGFPASGKSTFFHTHVIPKGYVYVNRDTLGSWQNCVSACERALKEGRSVTVDNTNPDPESRKRYVDVAKAAGVPCRCFHFSATLEQAKHNNRFREMAPSDSKHAKVNDMVFHSYKKHFQAPALSEGFSEILQIHFVPSFKDKQSETLFRQFSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCL0</accession>
    <name>A0A3P9BCL0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAST kinase domains 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004552728.1">
        <property type="nucleotide sequence ID" value="XM_004552671.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCL0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007645"/>
    <dbReference type="Ensembl" id="ENSMZET00005007963.1">
        <property type="protein sequence ID" value="ENSMZEP00005007645.1"/>
        <property type="gene ID" value="ENSMZEG00005005856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482037"/>
    <dbReference type="KEGG" id="mze:101482037"/>
    <dbReference type="CTD" id="22868"/>
    <dbReference type="GeneTree" id="ENSGT01030000234607"/>
    <dbReference type="OrthoDB" id="9369505at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23739">
        <property type="entry name" value="TBRG4-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF1">
        <property type="entry name" value="FAST KINASE DOMAIN-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="4">
        <location>
            <begin position="589"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="667" mass="75618" checksum="6DFBCB546DA67FE4" modified="2019-02-13" version="1">MSVWVTEEVMRRGLRFCSRGSLWQQRNFLLSAPIKDSCSPDKQFFHLWSPRQSQTWLSRSPVSSVRFYSQGANHGDDLEDGERLPSQPADTASAERQRKSPFLELLESCGSPSDVLDLTGKYSPTARQVSHCLTHMWATTKKMTDEQRRYELQLMFEHPAFDQLLQRAMKTLVHIRDEDVTYSLLSMVNLGVPQRSRVVQTFLRTCQEKLNDFDEKSLSILASSLEQMEDGANVRALKEGMRLVVEARLPGIKNVMALQTMMRLLGNDAPKDLKWKLEKKALSMTDHFSLPNAQYMISTMATMGFFSKPLLDVCSKKITENIHGIPFNRIFKLLQSCRELRYRDVHLLTSISDYVASSLDIWTNKQLLLFLSVFENLIFCPAALMDAYADKVIANPDVLTLKDLLCVLKVYSSLSYDLQDRRQQFLDSLSQVLISYLPKISAFELLKAVYCLCLLGHFPYAPLEQLLQSSVLEKLAGSKFPKSQERMFQTVDVCLRVDHPPLPQPLTVPASVLGDPTPSTPSVNPRLLLDLQSLLEDQVHMMLQEGVMVENLYFIDAAVTKPTPNQTSVCEARSGGGEGCSPAESSERIAVMYAPQSGFCYGTSNPRGPLAVKIRHLKILGYNSVLVTEQDLQSVSEEARIDFLRERIFPQHHRPETQPDEKEHLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCU0</accession>
    <name>A0A3P9BCU0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cathepsin F</fullName>
            <ecNumber evidence="14">3.4.22.41</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (kcat/Km) comparable to that of cathepsin L.</text>
            <dbReference type="EC" id="3.4.22.41"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cystatin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.41" evidence="14"/>
    <dbReference type="RefSeq" id="XP_004563245.1">
        <property type="nucleotide sequence ID" value="XM_004563188.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024660068.1">
        <property type="nucleotide sequence ID" value="XM_024804300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCU0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007730"/>
    <dbReference type="Ensembl" id="ENSMZET00005008048.1">
        <property type="protein sequence ID" value="ENSMZEP00005007730.1"/>
        <property type="gene ID" value="ENSMZEG00005005887.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469506"/>
    <dbReference type="KEGG" id="mze:101469506"/>
    <dbReference type="CTD" id="8722"/>
    <dbReference type="GeneTree" id="ENSGT00940000164681"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2250:FF:000001">
        <property type="entry name" value="Cathepsin F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000050">
        <property type="entry name" value="Cathepsin F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000004">
        <property type="entry name" value="Cystatin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018545710" description="Cathepsin F" evidence="16">
        <location>
            <begin position="26"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="17">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="19">
        <location>
            <begin position="177"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="18">
        <location>
            <begin position="262"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="475" mass="53344" checksum="83E2A0A5B735D22C" modified="2019-02-13" version="1">MVVILRCCPLIQWLSLAVLLGSVVGLGEDLDRPLLGPPGSSIRVHESDPGLKKALAFAEERYNRVSNAMHLRRVSRVISANKQLVKGIRYTLTVELSNTQCKKSTMLRTCDFYPELNQLKTEVCVFEVWDIPWQGASTLLKQKCQPKVEFEVEESNKVEDPSTSQPLEESVELLGRFKEFMTKYNKVYSSQEEVDRRLRIFHENLKTAEKLQALDQGSAEYGVTKFSDLTEEEFRSTYLNPLLSQWTLHQPMKPATPAKGPSPDSWDWRDHGAVSPVKNQGMCGSCWAFSVIGNIEGQWFLKNGTLLSLSEQELVDCDGLDQACRGGLPSNAYEAIEKLGGLETESDYSYTGHKQRCDFTTGKVAAYINSSVELPKEEKEIAAWLAENGPVSVALNAFAMQFYRKGISHPLKIFCNPWMIDHAVLLVGYGERKGIPFWAIKNSWGEDYGEQGYYNLYRGSNACGINKMCSSAVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD38</accession>
    <name>A0A3P9BD38_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pumilio homolog 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004548073.2">
        <property type="nucleotide sequence ID" value="XM_004548016.5"/>
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        <property type="gene ID" value="ENSMZEG00005005834.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
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        <location>
            <begin position="803"/>
            <end position="1145"/>
        </location>
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    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="823"/>
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            <begin position="859"/>
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            <begin position="895"/>
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            <begin position="1005"/>
            <end position="1040"/>
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            <begin position="1041"/>
            <end position="1076"/>
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        <location>
            <begin position="1080"/>
            <end position="1119"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="211"/>
            <end position="236"/>
        </location>
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            <begin position="278"/>
            <end position="310"/>
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            <begin position="461"/>
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            <begin position="586"/>
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    </feature>
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        <location>
            <begin position="624"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="670"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="221"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="310"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
    <sequence length="1163" mass="123436" checksum="CE7CD1868B21208B" modified="2019-02-13" version="1">MSSVCVLKRKAVLWQDSFSPHHRSTSPSMPVVLSSGGHAPPTGQTPQATPPSQQGVAGAGRSQDDAMVDYFFQRQHGEQPGKHRWPTGDNIHDSQVRSMDELNHDFQALALEGRAMGEQLLTGKKFWETDDSGKDGPKGIFLDQWRDSAWGASDHSVSQPIMVSRRPGQGFHGGGEVGVGSVMSPRSESGGLGVSMVEYVLSSSPADKLDSCLRKGPYGQRDGEVEEEKREKPKTTFEGEKLKELTEGESDVISDVINPNGLPVQNGLDVDVKEFGRPPGSMPAPGPEGDLLGGPGGVGPEGLTPLGGGGVPKPPDDFSGVEQGGVTMDPMESVMEPLQFDYNSQMPMDSAPTVGLFDYTNQQQLFQRNNALAVQQLTAAQQQQYALAAAQQPHIGLAPAFVPNPYIISAAPPGTDPYAAGLAAAATLGPAVMPPQYYGVTPWGVYPANLFQQQAAAANSSANQQAAGQGQQNQQQVMRAGGNQRPLTPSQGQQGQQNDQLVAAAAVNSALAFGQGLAAGVPGYPVLAPAAYYDQTGALVVNTGARSGPVRLMAPASVIISPSAAQAVAAAAASAGGANGGLGGGANGPFRAMTSQQPQQQGGPGGALGGSSFYGSSSLSSSSQSSSLFSQGSAQPGPGSASLGFSQQASSSLGATLGATLGGFGTAVANSSGGSGSRRDSLTGNSDLYKRTPSSLTPIGHGGFYNGTLGFSPSPGPVGMPLPNQGPSHSLTPPPSLSNHSSSSNLNLGGLTNGSGRFISAAPGAEAKYRNAASSGSSLFSPSSQLFPSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLRDIAGHIMEFSQDQHGSRFIQLKLERASSAERQLVFSEILQAAYQLMVDVFGNYVIQKFFEFGSLDQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVISEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPHALHFIIEAFKGQVFALSTHPYGCRVIQRILEHCLPEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRAEDKSKIVAEIRGNVLGLSQHKFASNVVEKCVTHASRAERAVLIDEVCSLTEGPHSALYTMMKDQYANYVVQKMIDVAEPTQRKIVMHKIRPHISTLRKYTYGKHILAKLEKYYMKNGVDLGPLCGPPNGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BE24</accession>
    <name>A0A3P9BE24_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arylsulfatase B</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024658875.1">
        <property type="nucleotide sequence ID" value="XM_024803107.1"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005008175"/>
    <dbReference type="Ensembl" id="ENSMZET00005008500.1">
        <property type="protein sequence ID" value="ENSMZEP00005008175.1"/>
        <property type="gene ID" value="ENSMZEG00005006208.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000007">
        <property type="entry name" value="Arylsulfatase family, member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF274">
        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="513" mass="57438" checksum="D755232B332C0453" modified="2019-02-13" version="1">MTEGNGKVVYWIIASTFIVNLAQTLAARQPHVVFILADDFGWYDIGYHGSEIRTPNLDKLSSRGVRLENYYVQPLCTPSRNQLMTGRYQIHTGMQHQIIWPCQPYCVPLDEKLLPQLMKEAGYATHMVGKWHLGMYMKDCLPTRRGFDTYLGYLTGGEDYFTHFRCYQSRSLNLSRCALDLRDGEDVATGYEGVYSTELLSQRAISIIERHNSQKPLFMYVALQAVHAPLQVPERYVTPYSFITDTNRRLYAGMVSAMDEAVGNITLALQKVGLWNNTVLVFSTDNGGQTLSGGSNWPLRGRKWSLWEGGVRGVGFVASPLLKQPGTMNRELIHISDWLPTLVGLAGGNATGTKPLDGFDVWNAISKGFASPRLELLHNIDPLYYDIAPCPGRQRELTLAQVANSGFNVSIHAAIRSSKWKLLTGYPGCDVWFPRPDGNTSDSSSSEVDQLKPVMLFNIEKDPEERNEVSAQFPKVFDLPLKAACRLEQEMLPAESRRPLSECGPRPLTCPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BH76</accession>
    <name>A0A3P9BH76_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho GTPase activating protein 22</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BH76"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009228"/>
    <dbReference type="Ensembl" id="ENSMZET00005009578.1">
        <property type="protein sequence ID" value="ENSMZEP00005009228.1"/>
        <property type="gene ID" value="ENSMZEG00005006972.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183015"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04390">
        <property type="entry name" value="RhoGAP_ARHGAP22_24_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000015">
        <property type="entry name" value="rho GTPase-activating protein 25 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF22">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="36"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="154"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="579"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="668" mass="73854" checksum="58D56CAAC4EDACF5" modified="2019-02-13" version="1">PLSPRSRQLMSRSKSMVMSEVSRGSCRPASPSLHEGALKAGWLKKQRSIMKNWQLRWFVLRSDQLYFYKDEEETKPQGCIPLQGCLVNELTANPDEPGRHLFEIVPGGTGEKDRAPISHESFLLMANSQSDMDDWVKAIRRVIWAPFGGGIFGQHLEDTVQYEKKFGPRLAPLLVEQCVDFIRERGLDEEGLFRMPGQANLVRELQEAFDCGDKPLFDSNTDVHTVASLLKLYLRELPEPVIPFSKYEDFLTCAQLLAKDEEEGVQELGKQVSTLPLPNYNLLKYICKFLDEVQSHCNENKMSVQNLATVFGPNILRPKMEDPVTIMEGTSLVQHLMTVLIREHNRLYSGREQEGPALPQTEIPIQGHHLQHRSLGAWISEEDLQSCPVSNPDQDLHSSASSLDAKLCAAVSPTQTPNPNPGPKLGSSSGKDTTSLSSGGGGGGSGGNWLMNGLSSLRGHRRTSSGERSTRDRDSTGSSQRLSTYDNVTSSSSMGSVPSVSSTPWSTSSCEISVPDSARMTTDASSEQDSCEAMELCSSSAACSENGNVATAAGVPSIIMSEDGDGEKLTLSSLVEGLKDELRKQKTTYEARIQKLEESSAALCAQMERLEQEMEQERKKQRMLEIKLRNSERAREDAENRNRLLEKEMEDFFATLGDLALGARTSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BM70</accession>
    <name>A0A3P9BM70_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MYC binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551067.1">
        <property type="nucleotide sequence ID" value="XM_004551010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BM70"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011029"/>
    <dbReference type="Ensembl" id="ENSMZET00005011411.1">
        <property type="protein sequence ID" value="ENSMZEP00005011029.1"/>
        <property type="gene ID" value="ENSMZEG00005008274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484779"/>
    <dbReference type="GeneTree" id="ENSGT00390000017974"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21937">
        <property type="entry name" value="ZIP_MycBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="105" mass="11805" checksum="4DC43250DCFE9EC7" modified="2019-02-13" version="1">MAHYKQGPDPKREQFRRYLEKAGVVDSLTSVLVSLYEQQEKPNNALEFVKQQLGAVGKTSEDAEALQQEVINLRQKCARLAGENKELKAKLQRYESVPEDGGTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BMF7</accession>
    <name>A0A3P9BMF7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BMF7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011119"/>
    <dbReference type="Ensembl" id="ENSMZET00005011506.1">
        <property type="protein sequence ID" value="ENSMZEP00005011119.1"/>
        <property type="gene ID" value="ENSMZEG00005008344.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160560"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF1">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31025" checksum="F639D611DD18A76F" modified="2019-02-13" version="1">MLNCKCTLNPIVIFLMNSERERDLQLVRDYKPHKDVQHLRIMLYGPPGAGKSSFINSVDSVLRGKIATRALAAATSGDSFTIAVCMRMYSGEPGTFYPFVFNDTMGLQSSDKGIHVEDIKLAIRGHVNEDYRFNPTSPLPETNSSYNSFPTLDDKVHILVLVIPADTVSIMNDETVRKMKDVRSAARIPQIAIMTKIDEACPEVKKDIKNVYKSKYLNKQVNMNLGIPLNCIFLVKNYHTEIETENDVDSLILSVLKKIIDYGEDYLNDQDDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BN96</accession>
    <name>A0A3P9BN96_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tumor protein p63 regulated 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPRG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552888.1">
        <property type="nucleotide sequence ID" value="XM_004552831.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BN96"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011398"/>
    <dbReference type="Ensembl" id="ENSMZET00005011792.1">
        <property type="protein sequence ID" value="ENSMZEP00005011398.1"/>
        <property type="gene ID" value="ENSMZEG00005008561.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005011798.1">
        <property type="protein sequence ID" value="ENSMZEP00005011403.1"/>
        <property type="gene ID" value="ENSMZEG00005008561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474409"/>
    <dbReference type="KEGG" id="mze:101474409"/>
    <dbReference type="CTD" id="285386"/>
    <dbReference type="GeneTree" id="ENSGT00390000001652"/>
    <dbReference type="OrthoDB" id="10012704at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040242">
        <property type="entry name" value="TPRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108:SF6">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="79"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="286" mass="32598" checksum="54FFD65758E937BC" modified="2019-02-13" version="1">MADAEDEVVKGSEEQQQQQAEEEVDLSSSPTPPEDSQTAAGRKGDAQERPAESVATSTQGRHLLVEPTLDQFKLRKFFVLRPGTLNQAIKDVEALVNEEVDGSVLSVWLMAEVDHWNNEKERIVLITEFSLLVFKYDFMMFNCDQMQRIPLNFVDRISHGTFSFPKRSLLERNGEGVRVFWDRLREPSFTSRWNPFATDFPFITFTYHPVRKISDVFTALTDVEKFREQLKDAAQKVHTLKPIPGKANGVLVLNQPIQIEAYVGFMSFLGNENKLGYCMARGNLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNS2</accession>
    <name>A0A3P9BNS2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Discs, large (Drosophila) homolog-associated protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562392.1">
        <property type="nucleotide sequence ID" value="XM_004562335.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNS2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011588"/>
    <dbReference type="Ensembl" id="ENSMZET00005011990.1">
        <property type="protein sequence ID" value="ENSMZEP00005011588.1"/>
        <property type="gene ID" value="ENSMZEG00005008702.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481395"/>
    <dbReference type="KEGG" id="mze:101481395"/>
    <dbReference type="CTD" id="9787"/>
    <dbReference type="GeneTree" id="ENSGT00940000158652"/>
    <dbReference type="OrthoDB" id="10023951at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF1">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="912" mass="99720" checksum="5B819406DCB2B76C" modified="2019-02-13" version="1">MESRFAHLRQRDTSVSMLRVKMSRRRSHSQKENRERTVNTRRQLDKLPELEMSSLNASIAVANMSTIQEKTKNNEKPAKAKAVEDRLKQLERWKERKALEKEKEKRERERKGVFKIGLYHPTGTITSLPAVPDASAKIQEKKANTAPSQSIRVTRSMKQQQQVEKPLKIQDPNTGLKKGQPAVERSTRTRLASAKPASTTTKTKEAPAVRALSTRSANRPPVPVVKGKPKDKTAVSDARTTRSRANLNPVAPLSGAQRNCKEAVNDTIHHAVSEEPELTVPEMQDIEKRPSPPSPTPCAEEEDMVVDQSPAKPVSADLVPSTSSFAPEGFLFQAPTGLSSFKFEPLTPRSADSFLTPSSSFNLPPAPVFSDEQSESCPPKSPLRSPPHTSPTVAPPSPGGSVETKHDVPYFRSEMANETERLMSLSLHWESKVEDESIPEEMRDRMRTAVGQARLLMKERFNQFSGLVDDCELGRGEKITTCTDLQGFWDMVYYQVEDVNKKFDALKEAEERGWVEEHKPPPRQKKVVKKQLAASAKPAGTNAAAKARLAAAKAAMKAKKQAAEAEKAAGAANTEDCLVLSSQNPHPQAGAQRQDTVVFDGGFFQVESPAKQSVRRSSHLNAAVLPGVSPCSTYLSPRRVTRRSLALAQTPVQHVHAPAHLRLTLRQTPEPKSQCGTPQATQSRRDIVNISMDFSPVKEVISDDTQPDGCPAQVSEKVFTDIPSVPQLLPAILEPAEDVTVDNPVSPAVPGSPCKQPAVPPAPEPSSAPSFTLSPCATPSQPSVSSSAVQGLVETLCHTPDSTVVEEISGLDFERYLQPSDRCSLSPRDTVATETLSPMAVDVAMESPRGQATNFLTEKESALPVVSSVLTRHSRQVQTAESALLLFTPDLKDKIRQSVCPSDLMVFTPPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BPD1</accession>
    <name>A0A3P9BPD1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 2 member 15b</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539024.1">
        <property type="nucleotide sequence ID" value="XM_004538967.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BPD1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011486"/>
    <dbReference type="Ensembl" id="ENSMZET00005011886.1">
        <property type="protein sequence ID" value="ENSMZEP00005011486.1"/>
        <property type="gene ID" value="ENSMZEG00005008607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474613"/>
    <dbReference type="KEGG" id="mze:101474613"/>
    <dbReference type="CTD" id="552924"/>
    <dbReference type="GeneTree" id="ENSGT00940000164095"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070837">
        <property type="term" value="P:dehydroascorbic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17432">
        <property type="entry name" value="MFS_GLUT_Class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000029">
        <property type="entry name" value="solute carrier family 2, facilitated glucose transporter member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF25">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="25"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="513" mass="56457" checksum="5678A20FA5686283" modified="2019-02-13" version="1">MAEELLQGNNEKLTSHLTKPLLAVAFLASFGSSMLYGYNLAVVNSPAKYIKDFYNETLLESHGLTPDGHLLTVLYSLTVSIFAIGGMTGALLVGRLVTKYGRKGTLVRSTALVFMGGALMGFSRWCRIPEMVIIGRFITGVHSGISLSVVPMYLGEIAPKNLRGFLGLVPSIHICLGVFIAQVLGLSAILGKEEHWPLLLSLVAVPTMVQLILLPWFPESPRYLLIERGDVHATIAALKWFRTKGNIQAEVEEMQEEQRSLSSMQTLSVCSLLMDSCVRWQVLTVAVVNIGMQLSGIDAIWFYTNDIFRNAGIADPYIQYTTVGTGAIEVISGMLGCFTIERLGRRPLMIGGFLFMGLCCAGITVSVLFQPQLSYMRYISVGCVIGIIAGFCIGPAGVPFLITTELFKQSHRPAAYTVAGCLNWMSNFTIGFVFPFLEIATGPFCYLIFCVVCLGVAVYTFFIIPETKNKTFLEISQMFATKNEICEEELYPNSELKMALMNGYGTLDFHNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRM5</accession>
    <name>A0A3P9BRM5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP. Component of the replisome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547112.1">
        <property type="nucleotide sequence ID" value="XM_004547055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRM5"/>
    <dbReference type="SMR" id="A0A3P9BRM5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012577"/>
    <dbReference type="Ensembl" id="ENSMZET00005013022.1">
        <property type="protein sequence ID" value="ENSMZEP00005012577.1"/>
        <property type="gene ID" value="ENSMZEG00005009452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482883"/>
    <dbReference type="KEGG" id="mze:101482883"/>
    <dbReference type="CTD" id="5111"/>
    <dbReference type="GeneTree" id="ENSGT00390000004965"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014823">
        <property type="term" value="P:response to activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000008">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="12">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="260" mass="28689" checksum="A9701765B59532E6" modified="2019-02-13" version="1">MFEARLVQGSILKKVLEALKDLITEACWDVSSSGISLQSMDSSHVSLVQLTLRHDGFDSYRCDRNLAMGVNLSSMSKILKCAGNEDIITLRAEDNADTLALVFETLNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLSQIGDAVMISCAKDGVKFSASGELGTGNIKLSQTSNVDKEDEAVTIEMNEPVQLIFALNYLNFFTKATPLSKTVTLSMSADIPLVVEYKIADMGHIKYYLAPKIDEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BUA6</accession>
    <name>A0A3P9BUA6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tudor domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDRD5 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BUA6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013216"/>
    <dbReference type="Ensembl" id="ENSMZET00005013666.1">
        <property type="protein sequence ID" value="ENSMZEP00005013216.1"/>
        <property type="gene ID" value="ENSMZEG00005009928.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159902"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF19">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="HTH OST-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="11">
        <location>
            <begin position="174"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="11">
        <location>
            <begin position="371"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="10">
        <location>
            <begin position="536"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="752" mass="83616" checksum="30BB783C99E11774" modified="2019-02-13" version="1">MRLPSHLNCRIIFSKVVLCVEKGRVSAVLLYARFLTSSCCVFQMYSGKMNHENILAQLKKEVRSLLISSKNGLAPEELLRDYATMLGHSMPLKVLGFRNILDMSQQMPDVVSINFRPDGSIFLKAVGHETTRRIEELVTKQRSKPNKKVSRGGARYFPTHSVSHYVVLPRRGPAPPAIPAQLRTELRILLSQGPIRLSDLEASFWRFFGRPLCIRSYGFYSTGEMLGAAADMLVISQSRFGSLVFLREHMIPRPLLKLPASTKRGGLIKPALPRTCRPDSERPDVKLQSPKTPPAEAPEKPTSLNQTSTQNSLDSARSEPGTVDSKPGADEKNQETKAQLSSEIQLFDNHVLQLEEGLRQQILENGVAGTINQELKDKLRAVIGQTDGGLSVHKLPAEYKRCFGEDLPLQQSGFVSVTELIGAMSDTFHLRPNTRPGVSLSLHRLLQPAYMRNDYLISAIPVHLSPAVPLDALQSKPLKPPTRHCARELVEVLVERVESPGYFYIRFSETEEARAMENMIFQLLYGLFNRAYSDQFVRRGQVCCVSPDGLWFYRVVIHKVISPTQVEVYYVDFGDLTVVPTANLKFLKSAYSVLPAQAVPSSLAGIKPTSVSSWTPGATADFQKLCCDRTLVGALDCYSGDVLQLYLCDTHTDDDIYIHTVLLSQGHGTPCSPADSCQVTPVSLYLGEGVADLPEVREEMISSPEPGDTSEESIMDKLKVAHWSHRNIVQGYSALAPWDVVRFGKRSFYVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BUR0</accession>
    <name>A0A3P9BUR0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BUR0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013619"/>
    <dbReference type="Ensembl" id="ENSMZET00005014084.1">
        <property type="protein sequence ID" value="ENSMZEP00005013619.1"/>
        <property type="gene ID" value="ENSMZEG00005010250.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164472"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="268"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="547" mass="61580" checksum="B7EAB768E4EF9E99" modified="2019-02-13" version="1">MVVNRSESQVKVKLIDFGLACNTSAVIPGDCVGTIGYCAPEIMLGTPYDEAIDMWSLGLVAVELATGVPLYPGEDDYDVLKFIIETQGQLPDHLLESGLYTDSYFIEDNHNKQRWTFKTPEQFQYETDYRSKETRLIKLKCLDDLEQLLKVRRGPENGQTLFVRLIKEMLALDANQRITPSEVLKHPFFDPGLSRRTPCTDMNSTGGELLVLSQQHSSWKSHGSQKFSCSFQNSVEFPQKRDINTSANPSASEDDLQITEGTILGDHHVVEAFLGEGGFGLVTRCRDTKNNKTVAIKVNKSDPEILLQAKLEIFILEQLQRLDPDRCNIVEWNGYFLDGERICLNFELLDQSLSDYIGDRNNRGLPMREIRPILHQLTNVLFHLGSVGIVHADLKPGNIMVVNRSESQVKVKLIDFGLACPASAVIPGDRVGKIGYCAPEVMLGIPYDKGYYRSKETRSIKLKRLHDLEQLLKVRRGSENGQSLFVRLIKELLALDANQRITPSEVLKHPFFDPGLSRRTPCTDMNSTGAQNLVLSQQQSSFGWPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWL5</accession>
    <name>A0A3P9BWL5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylosome protein WDR77</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methylosome protein 50</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">WD repeat-containing protein 77</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004544873.2">
        <property type="nucleotide sequence ID" value="XM_004544816.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWL5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014252"/>
    <dbReference type="Ensembl" id="ENSMZET00005014728.1">
        <property type="protein sequence ID" value="ENSMZEP00005014252.1"/>
        <property type="gene ID" value="ENSMZEG00005010734.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010711"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034709">
        <property type="term" value="C:methylosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007309">
        <property type="term" value="P:oocyte axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052139">
        <property type="entry name" value="Methylosome_Comp_WDR77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46853">
        <property type="entry name" value="METHYLOSOME PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46853:SF1">
        <property type="entry name" value="METHYLOSOME PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="337" mass="36855" checksum="FE5350E7A407663E" modified="2019-02-13" version="1">MNSSVDTSMTKENRWDIPPNAPACMERHLCAAQYRADGTLLLGASSLSGRSWQGSVWIYSDPDQAPSEGFCKAGVQTEAGVTDVKWVSEKGIIVASDSGALELWELAEDECLLVNRFTKHDHDHIVTTVSPVVGATAAVTGSMDCRIKVWDLSQETVVTTYNVHTQPVTCVACSPTDESLFLSCSQDGRVLLWDRRKPNKPASRIDVESPSCSPTSLAWHPHHRSTIAFGDELGRVTVKDFLGSEPSQVENIHSRRVNELAFSTHSTPLLASVSDDCSVAVMDSELREILRDRRHQDYVKGVSWLHNGSSTLTTVGWDHLVLHHKVGPADGIPSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXD6</accession>
    <name>A0A3P9BXD6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fucolectin-5-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXD6"/>
    <dbReference type="Ensembl" id="ENSMZET00005015000.1">
        <property type="protein sequence ID" value="ENSMZEP00005014517.1"/>
        <property type="gene ID" value="ENSMZEG00005010922.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000248575"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF8">
        <property type="entry name" value="SI:CH211-215K15.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018336396" evidence="10">
        <location>
            <begin position="16"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="11">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="11">
        <location>
            <begin position="159"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="294" mass="32137" checksum="BE490B4706124316" modified="2019-02-13" version="1">MISFICIMLLPENVALRGKATQSTCMSTVLSAAYAAIDGNRDSDLRHGSCSHTDQQTDPWWRVDLLESYIVTSITITNRGDCCHEELNGLEIYIGNSLNNDGLNNPKVGKISEVGAGKSYTVNFAGRVEGRYVTLTLPGSERILALCEVEVYGYHAPTGENLALQGKASQSSLYTIGIAYNAIDGNYNGIWGGASCTHTKPDFSPWWRLDLRKTHKVFSVKVLNVIDSLPERLNGAEIRIGDSLENNGNYNPRCAVISSIPGGSIQEFHCNAIVPGRHEYLTLCEVEVYGSVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYH3</accession>
    <name>A0A3P9BYH3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYH3"/>
    <dbReference type="Ensembl" id="ENSMZET00005015527.1">
        <property type="protein sequence ID" value="ENSMZEP00005015038.1"/>
        <property type="gene ID" value="ENSMZEG00005011292.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176877"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="122" mass="13878" checksum="3D5F11616F56CD52" modified="2019-02-13" version="1">MVRTCCAVGCKVRLHNRQGNKVENGLSFHSFPTWKQHEAAHVSDVTKRRRLVWIAAVRPADIQFDSISKYLLVCSRHFHSGNSSISIRSSPYILTPSYTPLFFSFPSVCSICLPDNHWTQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZ64</accession>
    <name>A0A3P9BZ64_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">SOSS complex subunit C</fullName>
            <shortName evidence="6">SOSS-C</shortName>
            <shortName evidence="6">SSB-interacting protein 1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 6">Sensor of single-strand DNA complex subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5 6">Sensor of ssDNA subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4 6">Single-stranded DNA-binding protein-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SOSS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SOSS-C family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZ64"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015265"/>
    <dbReference type="Ensembl" id="ENSMZET00005015758.1">
        <property type="protein sequence ID" value="ENSMZEP00005015265.1"/>
        <property type="gene ID" value="ENSMZEG00005011456.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006366"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070876">
        <property type="term" value="C:SOSS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031821">
        <property type="entry name" value="SOSSC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31526">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31526:SF2">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15925">
        <property type="entry name" value="SOSSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="89" mass="9979" checksum="D1E3B06F29B9C300" modified="2019-02-13" version="1">MNFRFTVFHSAKPKHNQSWSMNSPGANIPLSSRPSLKEVRDSAEQQHIAAQQKAALQHAHIHSSGFFITQDSSFGNLILPVLPRLEPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZQ0</accession>
    <name>A0A3P9BZQ0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ubiquitin-conjugating enzyme E2Ia</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZQ0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015111"/>
    <dbReference type="Ensembl" id="ENSMZET00005015601.1">
        <property type="protein sequence ID" value="ENSMZEP00005015111.1"/>
        <property type="gene ID" value="ENSMZEG00005011333.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075088"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060216">
        <property type="term" value="P:definitive hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036306">
        <property type="term" value="P:embryonic heart tube elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000013">
        <property type="entry name" value="SUMO-conjugating enzyme UBC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017984911" evidence="11">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="176" mass="20118" checksum="343FF0AC9A783416" modified="2019-02-13" version="1">MFGFLINLTLFLCRSPQIMSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0Q3</accession>
    <name>A0A3P9C0Q3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase RNF182</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RING finger protein 182</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase RNF182</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts with ATP6V0C.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559001.1">
        <property type="nucleotide sequence ID" value="XM_004558944.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0Q3"/>
    <dbReference type="Ensembl" id="ENSMZET00005016324.1">
        <property type="protein sequence ID" value="ENSMZEP00005015815.1"/>
        <property type="gene ID" value="ENSMZEG00005011880.1"/>
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        <location>
            <begin position="205"/>
            <end position="224"/>
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            <begin position="230"/>
            <end position="252"/>
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            <begin position="33"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="272" mass="29674" checksum="343175C2ABE90C3B" modified="2019-02-13" version="1">MSLLKEVEPGQEMEGKVQTWAQSLVYTLEELECKICYNRYDTRSRKPKLLGCLHRVCAKCLKKMVDMGESSPSIISCPFCRHETYVPDEEVWLMEDDRHILAVLSCQDRARRGGGAGSGSGGEVVLSPSSLTGGGAAGSGEEASHRSSDCLVITIMELPEESPSSDSLSMLNVVGLYHAPSLDSLPCNLPGQKCRAWTSRSFPRCLLGALCLVYFSSLPLGIYLLMIGQLWLGVVLVSLVPSTLLLLVLYGFCQCLCHELMEALAARTHSLP</sequence>
</entry>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
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                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015910.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="169" mass="19937" checksum="1052E39CFFD77B9B" modified="2019-02-13" version="1">MILSFFWGLLCDGFGQPPPRHGLKLLVWYVQNCLDNNMRALCDPYRGEYGFHLFQNKGPVLPVIKDRQQWSYYTIGNLHYPGAEKLPYEVRRYYNRSNPKSNMDRVLVKYNKNNKRIDELYASAHYEPKETYRIGPNLLASLRKKIAFVSTDLQLQTEDEHVSQSSRSW</sequence>
</entry>
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    <name>A0A3P9C1P9_9CICH</name>
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        <recommendedName>
            <fullName evidence="8">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="D'Cotta H."/>
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                <person name="Okada N."/>
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                <person name="Venkatesh B."/>
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                <person name="Meyer A."/>
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                <person name="Streelman J.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="6">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR1_Superfamily_Member"/>
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    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF885">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="94"/>
            <end position="121"/>
        </location>
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            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="338" mass="38401" checksum="D64E4769E351D727" modified="2019-02-13" version="1">MQKMGNSSETVSFVLAAYGNVGALKYMYFSIILFWYVSICVANTVLILVIHVDRRLHEPMYILLSNLCVNEINVSTSLYPLLLSQMFSDSHEVTLPWCFLQMCCMYTTASAEFCSLAAMAYDRYISICHPLRYNVIMNTERVFILILLVWVYSFLIFIFSFSFIFSLTFCGNVVNNVYCDHQLLIRLSCSLSFHSFISDIFFVFVSIFIPFNLISVSYVKILAICRKTSIENKQKAVTTCTPQLVSVSNLFVGSAMVIYKYQLVSPIGHELSGILAKLNSYWESSLLKLAQSVTASWGTIMKKSLADLNPRGILFLDSFANYSLSITNIMLKNKGIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3P1</accession>
    <name>A0A3P9C3P1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005016742"/>
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        <property type="gene ID" value="ENSMZEG00005012581.1"/>
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        <property type="term" value="F:cysteine-type endopeptidase activity"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="110" mass="12337" checksum="98F72C4508F2090A" modified="2019-02-13" version="1">MADTPFTLAKKRVTAENFTQLLEALVTDNVLNELEKERIQETNQTRADKARDFIDTVKKKGEKACRIMISHLRTIDPTVSCQLGLSSGPSVRLGEKKNISVMIFIIAQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4V4</accession>
    <name>A0A3P9C4V4_9CICH</name>
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            <fullName evidence="1">Gypsy retrotransposon integrase-like protein 1</fullName>
        </recommendedName>
    </protein>
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        <name type="common">zebra mbuna</name>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4V4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017132"/>
    <dbReference type="Ensembl" id="ENSMZET00005017678.1">
        <property type="protein sequence ID" value="ENSMZEP00005017132.1"/>
        <property type="gene ID" value="ENSMZEG00005012874.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000214408"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrase_cat-core"/>
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        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="130"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="302" mass="33457" checksum="2898FCA99979C763" modified="2019-02-13" version="1">MLESSEGGTLVLAPGFRGAVSGAHLPLLPQTRSGGKQRRIVEPKSTCALHSLKELKLFAPTSMKGTLLDYYHDHPTAGHLGVSKTLARLRFRFFWPKMAADVKRYVISCSVCQLTKPSQKKAAGLLVPIVPQKPWEYVGVDFVGPLPRTPTGNAYLIVFVDYLTKWVEASAVKEATSQVAAGKFVTDIFARHGTPTYLISDRGSPFVSELFEHVVSALGSVHRLTTAYHPQTNATERVNRTLKTAIRAYVGDKHTSWDKFLPQICFALRTAPHDSTGMTPAMMLYGRELDTPLDLITHFRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C5A4</accession>
    <name>A0A3P9C5A4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_014263794.1">
        <property type="nucleotide sequence ID" value="XM_014408308.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014263795.1">
        <property type="nucleotide sequence ID" value="XM_014408309.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C5A4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017277"/>
    <dbReference type="Ensembl" id="ENSMZET00005017824.1">
        <property type="protein sequence ID" value="ENSMZEP00005017277.1"/>
        <property type="gene ID" value="ENSMZEG00005012984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465124"/>
    <dbReference type="KEGG" id="mze:101465124"/>
    <dbReference type="CTD" id="1353"/>
    <dbReference type="GeneTree" id="ENSGT00390000007512"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="257" mass="29252" checksum="852735C2C054A622" modified="2019-02-13" version="1">MLLPLLLRPPLCLPQASVVLTRCVLTLRCGAPRGLRSQAKNFLWRWRPQRLHSRGRSRKTQSQEEEWRNRNKTALTYIAAAGVGMIGLAYAAVPLYRLYCQASGLGGTAVAGHDMEQVATMTPVKERVIKVTFNADTHASMQWNFRPQQTEIFVVPGETALAFYRAKNPTDKPIIGISTYNVVPFDAGQYFNKIQCFCFEEQRLNPHEEVDMPVFFYIDPEFDNDPRMARVDTITLSYTFFEAKEGQMLPLPGYSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6D6</accession>
    <name>A0A3P9C6D6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myc target 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540189.1">
        <property type="nucleotide sequence ID" value="XM_004540132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C6D6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017833"/>
    <dbReference type="Ensembl" id="ENSMZET00005018417.1">
        <property type="protein sequence ID" value="ENSMZEP00005017833.1"/>
        <property type="gene ID" value="ENSMZEG00005013413.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471419"/>
    <dbReference type="KEGG" id="mze:101471419"/>
    <dbReference type="CTD" id="100537522"/>
    <dbReference type="GeneTree" id="ENSGT00390000011642"/>
    <dbReference type="OrthoDB" id="9943706at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029180">
        <property type="entry name" value="Myc_target_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14869">
        <property type="entry name" value="MYC TARGET PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14869:SF0">
        <property type="entry name" value="MYC TARGET PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15179">
        <property type="entry name" value="Myc_target_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="183" mass="19788" checksum="B6AB367C46C67B4A" modified="2019-02-13" version="1">MAQNKTDPSLEIDKSFNLGDMILAFCLSVLVGLLLGALIYVLLTWASRRRATARITRHSKKKSGASQTNDATSSQLGLYRSTFLSVYRQPSLEPVGPLGSKPGAETSTFRPLPKKSRPALDMGDDTQVSEDAAPSNSSDSASLVSNKRHSFWLGNNGLKGFLPSQTPPPAYDTVIHAFEETCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6U9</accession>
    <name>A0A3P9C6U9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sialic acid acetylesterase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014265512.1">
        <property type="nucleotide sequence ID" value="XM_014410026.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C6U9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018000"/>
    <dbReference type="Ensembl" id="ENSMZET00005018587.1">
        <property type="protein sequence ID" value="ENSMZEP00005018000.1"/>
        <property type="gene ID" value="ENSMZEG00005013534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486842"/>
    <dbReference type="KEGG" id="mze:101486842"/>
    <dbReference type="CTD" id="54414"/>
    <dbReference type="GeneTree" id="ENSGT00390000010608"/>
    <dbReference type="OrthoDB" id="42638at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901:SF0">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017928602" evidence="2">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Sialate O-acetylesterase" evidence="3">
        <location>
            <begin position="108"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="500" mass="55805" checksum="962C313E20AC1602" modified="2019-02-13" version="1">MAATLCVVFALLASLHTCDGKLRFASYYGDHMVLQKSPERAVLWGYGPEGAQVTVSLFGLFKRQASLVTVTNGIWQVTLDPVAAGGPYNVTAKVQNDSATLTDVLFGDIWMCGGQSNMWFNMTQIFNATEELSVVAKYPYVRPFMVALNTSGIELMDLIEVEIPWSVPTASVVEEFSAVCWLFGRYMYETLKYPIGLVESCWGGTPVEVWSSSRALKRCQEVPVVDGPKKNSILWNSMIHPLLNMTIKGALWYQGEANAEYNQDKYNCSFPAMIDDWRMAFHQGSGGQTAPDFPFGFVQLSTYIKTSKDDGFPNIRWHQTADFGFVPNLRMKKTFMAVALDLPDATSPYGTIHPRDKQDVAYRLTLGARAVAYEEENVPFLGPFPKEIASTQMYVNITYDQAVSVTSSKDIFEVCCSDIWAPCGPKSLWLQTPIVGWDLTTIQVSAAVCQSSEVAAVRYAWRDWPCEFKACPVYSASWILPAPPFIINHSSWKGGIWKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C723</accession>
    <name>A0A3P9C723_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C723"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017892"/>
    <dbReference type="Ensembl" id="ENSMZET00005018476.1">
        <property type="protein sequence ID" value="ENSMZEP00005017892.1"/>
        <property type="gene ID" value="ENSMZEG00005013453.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183016"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF26">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="332" mass="38092" checksum="D2CFF4B5D8807B29" modified="2019-02-13" version="1">MDRQTDFKIASWNFKGLNNGIKRKKILTYLKLSRVDIAFIQEMHMCKSEALKLKCSWVGKVFSSPGTGKSRGVSVLIHKAVSFTETKVITDKEGRFILVYGQLLDTPIISCNIYAPNADILAFFHNLSQYLLELEGAQIVVGGDFNQILDQDLDRSLPRRGTENLGLNDIWRTMHPEGREYSFYSPPHNVYTRIDYFLISEALVNNSIDSSIGNIVFSDHVRRWHLNVSLIKDSGFIKLIRDEIQFYKQTNNREDTTLATWWDAMKAYLRGRTISYASFKKKAANKNIITLEAKLKALEAVRSHTEDGVTLNKIVKVKYKLNVLYNRKAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7Q9</accession>
    <name>A0A3P9C7Q9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7Q9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018137"/>
    <dbReference type="Ensembl" id="ENSMZET00005018726.1">
        <property type="protein sequence ID" value="ENSMZEP00005018137.1"/>
        <property type="gene ID" value="ENSMZEG00005013632.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164735"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="758" mass="87309" checksum="BD666FD87745A2D3" modified="2019-02-13" version="1">MRQAVISLILKKDKDHLDCGSYRPIPLLNTDTKILAKVLACRLEKHLPSIISPDQTGFIKNRYSFFNIRRLLNIIYSHVKGTVLETVISLDAEKAFDRVRWDFLFHTLEKFGLGSNFVSWIKVLYCDPVAAIRTNNSLSPFFQLQRGTRQGCPLSPLLFAIAIEPLAIALRHCVEVEGIRRGDIEHKVSLYADDMLLFISNPSNSLPKLLDVLKEFGTISGYKVNFGKSEAMPLGTITGELSSILAPFKLSYNKFKYLGIWITQNHRDLYKTNYLPLLSKLKEDFGKWESLPLSLGGRLNIIKMTIFPKFLYLFQCLPIFLTKSFFNNLNSQISSFIWNKKPPRLKQSVLQRPRSAGGLALLNFLFYYWAANIRALLYWMKDHDNLSSSWVTLERLSVSQSSLVSLLCAKLPLARPISSFTTNPLVVHSLKLWYQLRRHFKQTELSLNAPPHRHCMFSPSLTDEAFNIWTKLGITSMAALFTDNIFSSFEQLVNKFKIPQSHFFRYLQLRNFVASNTDCFPSCPPPSLLDDIFDFKPNAKRVISDVYELLSNFRLSTLQSLRERWGSDLGQRITDETWHKIINSISSSSICLKHVVIQFKVVHRLHWSKTRLSKIKDGFDPTCDRCKREPASLFHMFWACPKLGSFWKSIFETISNIFGVPIAPCPFIAIFGVTPCGASLSKSYSDLLAFCTLLARRMILLKWKEPLPPVYGQWVKDVMYYTQLEKIRYTVKGSVRRFYDTWQPFLTYFERLSPDTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7V2</accession>
    <name>A0A3P9C7V2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Survival of motor neuron 1, telomeric</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
            <location evidence="10">Gem</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544416.1">
        <property type="nucleotide sequence ID" value="XM_004544359.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7V2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018144"/>
    <dbReference type="Ensembl" id="ENSMZET00005018733.1">
        <property type="protein sequence ID" value="ENSMZEP00005018144.1"/>
        <property type="gene ID" value="ENSMZEG00005013634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480926"/>
    <dbReference type="KEGG" id="mze:101480926"/>
    <dbReference type="CTD" id="6606"/>
    <dbReference type="GeneTree" id="ENSGT00940000153352"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097504">
        <property type="term" value="C:Gemini of Cajal bodies"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140060">
        <property type="term" value="P:axon arborization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070657">
        <property type="term" value="P:neuromast regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070050">
        <property type="term" value="P:neuron cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048936">
        <property type="term" value="P:peripheral nervous system neuron axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903862">
        <property type="term" value="P:positive regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048841">
        <property type="term" value="P:regulation of axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904396">
        <property type="term" value="P:regulation of neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051124">
        <property type="term" value="P:synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20398">
        <property type="entry name" value="Tudor_SMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000038">
        <property type="entry name" value="Survival of motor neuron-related-splicing factor 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047298">
        <property type="entry name" value="Tudor_SMN_eumet"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="12">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="279" mass="31017" checksum="39A19B4CE3ACD07B" modified="2019-02-13" version="1">MANGCKEVLFTRGTGQSDDSDIWDDTALIKAYDKAVASFKTALKGEDEPQISKKNQPGKKRKNNKKNQSRKRNNAAPEKEWQVGNSCSAYWSEDGQLYAATIASIDKKRGTCIVVYTGYGNEEEQNLEDLLSEFSEGDEESNTKVHEAESSTEESDRSATPNQHKQSPNKGHKSKTHKESPPMWAPGFPPIPPPMHAFRQGSSKRSGSHGPVPPPWPPMMPFGPPMVPPPPPMSPDMVDDEALGSMLISWYMSGYHTGYYLGLKQGRKEASNWTKQHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CC33</accession>
    <name>A0A3P9CC33_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Pleiomorphic adenoma gene 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Cooperates with CBFB-MYH11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004572130.2">
        <property type="nucleotide sequence ID" value="XM_004572073.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CC33"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019682"/>
    <dbReference type="Ensembl" id="ENSMZET00005020312.1">
        <property type="protein sequence ID" value="ENSMZEP00005019682.1"/>
        <property type="gene ID" value="ENSMZEG00005014774.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480859"/>
    <dbReference type="KEGG" id="mze:101480859"/>
    <dbReference type="CTD" id="5324"/>
    <dbReference type="GeneTree" id="ENSGT00940000159246"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000425">
        <property type="entry name" value="PLAG1 like zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000231">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000256">
        <property type="entry name" value="PLAG1 like zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF23">
        <property type="entry name" value="PLAG1 LIKE ZINC FINGER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="477" mass="53116" checksum="7A3ACA3FAA958365" modified="2019-02-13" version="1">MATGTQGHRDQVLDKAKLAVPLGRRKRAEGKLKKNFPCQECQKAFNSLEKLKVHSYSHTGERPYRCSHPECTKAFVSKYKLLRHMATHSPEKNHKCSYCEKMFHRKDHLKNHLHTHDPHKEAFTCQECGKSYNTKLGFKRHLALHAANSGDLTCQVCLQPFPSTGVLLEHLKTHAGKSSGGTKEKKHRCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHARELLRVKTEPGDSLEPVVYDLASGSVKGELPGMLTPRLHQLNVYTGPVLDTEPFSSPTHPFSLKYPLGSNFTSYAVSSQEREQNLKGDLETYLMELQSSMPSSASEAQEAQLSSSKLELVPEVGVLEEANEEMSLSKMSTSVAAPAGDSLALSSSLMDFSQLFNFLPLNGPPYNQVGGSGGQGVTFLPNEEPASLVQLPSQAATGSEAAESPLQGLSSSFISNLSTPTTLPRFHQAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGB9</accession>
    <name>A0A3P9CGB9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CWC15 spliceosome associated protein homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the CWC15 family.</text>
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        <property type="component" value="LG10"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="237" mass="27425" checksum="D47210C9B8E34DD8" modified="2019-02-13" version="1">MTTAARPTFEPARGGRGKGEGDLSALSKQYSSRDLPGHTKIKYRQPTQDAPEEVRARDFRRELEERERVAVREKTRERGPREHTTSSSSSSSSSKRPRLDQIPAANLDADDPLTDDDEDEDSDEDSDDDDTAALLAELEKIKKERAEEQERKEREQKAEEERIRMENILSGNPLINLAGQQQQNQNQNSFRVKRRWDDDVVFKNCAKGVDEARKEKRFVNDTLRSEFHKKFMEKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGI9</accession>
    <name>A0A3P9CGI9_9CICH</name>
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            <fullName evidence="4">Eukaryotic translation initiation factor 4E nuclear import factor 1</fullName>
        </submittedName>
    </protein>
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        <name type="common">zebra mbuna</name>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="Ensembl" id="ENSMZET00005022096.1">
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        <property type="gene ID" value="ENSMZEG00005016063.1"/>
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    <dbReference type="GeneTree" id="ENSGT00390000012071"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="eIF4E-T"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10477">
        <property type="entry name" value="EIF4E-T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="115"/>
            <end position="153"/>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="883"/>
            <end position="927"/>
        </location>
    </feature>
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        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
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            <begin position="429"/>
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        </location>
    </feature>
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        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHS0</accession>
    <name>A0A3P9CHS0_9CICH</name>
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            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial</fullName>
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        </recommendedName>
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        <name evidence="1" type="primary">GATC</name>
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    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>African cichlids</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_004544616.1">
        <property type="nucleotide sequence ID" value="XM_004544559.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHS0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021396"/>
    <dbReference type="Ensembl" id="ENSMZET00005022104.1">
        <property type="protein sequence ID" value="ENSMZEP00005021396.1"/>
        <property type="gene ID" value="ENSMZEG00005016072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484106"/>
    <dbReference type="KEGG" id="mze:101484106"/>
    <dbReference type="CTD" id="283459"/>
    <dbReference type="GeneTree" id="ENSGT00390000018351"/>
    <dbReference type="OrthoDB" id="5394539at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="192" mass="21443" checksum="1853A783D84DA3ED" modified="2019-02-13" version="1">MSVFSLAASRTFRGVSVKIPRMLFSLLPNDGYSITILNSKRISWPQSHSANTTRLLSSEPLNQKIPKVATWEPVPEEQLPPPAHIPADLVDKLERLALVDFRTKQGLACLEKAIRFADQLHVVDTTGVEPMDSVLEDRVLYLREDAVMEGDCAEKLLQLSKSTVEEYFVAPPGNIPLPKGEERTAMLKNSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CI02</accession>
    <name>A0A3P9CI02_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cathepsin D</fullName>
            <ecNumber evidence="4">3.4.23.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.</text>
            <dbReference type="EC" id="3.4.23.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.5" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004566434.1">
        <property type="nucleotide sequence ID" value="XM_004566377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CI02"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021918"/>
    <dbReference type="Ensembl" id="ENSMZET00005022635.1">
        <property type="protein sequence ID" value="ENSMZEP00005021918.1"/>
        <property type="gene ID" value="ENSMZEG00005016428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473375"/>
    <dbReference type="KEGG" id="mze:101473375"/>
    <dbReference type="CTD" id="1509"/>
    <dbReference type="GeneTree" id="ENSGT00940000155733"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003406">
        <property type="term" value="P:retinal pigment epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05490">
        <property type="entry name" value="Cathepsin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1960:FF:000001">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000039">
        <property type="entry name" value="Cathepsin D preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000047">
        <property type="entry name" value="Cathepsin D preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012848">
        <property type="entry name" value="Aspartic_peptidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033144">
        <property type="entry name" value="Cathepsin_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF42">
        <property type="entry name" value="CATHEPSIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07966">
        <property type="entry name" value="A1_Propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018158155" description="Cathepsin D" evidence="16">
        <location>
            <begin position="19"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="17">
        <location>
            <begin position="76"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="396" mass="43288" checksum="5904C7596F9793DE" modified="2019-02-13" version="1">MRSLFLFVIAALALTNDALVRIPLKKFRSIRRELTDSGKGIKELVADKHSLKYNFGFPSSNGPTPETLKNYLDAQYYGEITLGTPPQKFTVVFDTGSSNLWVPSVHCSFFDIACWLHHKYNSAKSSTYVKNGTSFAIQYGSGSLSGYLSQDTCTIGDISIEKQIFGEAIKQPGVAFIAAKFDGILGMAYPRISVDGVVPVFDNIMNQKKVEKNVFSFYLNRNPDTEPGGELLLGGTDPKYYDGDFHYANISRQAYWQVHMDGMTVGSQLSLCKSGCEAIVDTGTSLITGPAAEVKALQKAIGAIPLIQGEYLVNCSKIPSLPVITFNVGGQSYTLTGEQYVLQESQAGKTICLSGFMGLDIPPPAGPLWILGDVFIGQYYTVFDRDNNRVGFAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJ16</accession>
    <name>A0A3P9CJ16_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytochrome P450 120</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJ16"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022298"/>
    <dbReference type="Ensembl" id="ENSMZET00005023041.1">
        <property type="protein sequence ID" value="ENSMZEP00005022298.1"/>
        <property type="gene ID" value="ENSMZEG00005016712.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000168590"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF252">
        <property type="entry name" value="CYTOCHROME P450 26B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="386" mass="43595" checksum="BB917624FDD3AF8E" modified="2019-02-13" version="1">MTKLPGNAGVSLLGDKSLEFYRDPVSFCQQRIEKHRSRMFLCRLMNRPTAFICSVQGMRELLCEKSSLFLKDPTDLMTNMYGDTIVTTNGKHSHTYKMSVYTAFKSLGTELVLGLFLNVRAEKQPELFQEISQLCTQHWHGLISAPVNVKVPMWSSGFSIALDARNKLMDIIKDKLENDKEGFVGSLGSLPLPDSSSAAQHLLLFISALIPKALASLLTSFTLALARRQAAEDPDYLCRVLLEVQRLWPPFIGGRRIADQDSTLMGFHVPKDFGVIYISHAVHRDPEVFQEPDAFLPERWSGRNEGHEHFLCSFGNGPRSCIGAKLTNVFLKEACVYLLNNFDWCLDPPVQNLEYKWLPVSRPANPPTVTFTQRDHTLSVYFCEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJZ2</accession>
    <name>A0A3P9CJZ2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="20">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:18106"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Mn(2+)(in) + ATP + H2O = Mn(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:66821"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Monomer. Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="20"/>
    <dbReference type="RefSeq" id="XP_024659930.1">
        <property type="nucleotide sequence ID" value="XM_024804162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJZ2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022462"/>
    <dbReference type="Ensembl" id="ENSMZET00005023209.1">
        <property type="protein sequence ID" value="ENSMZEP00005022462.1"/>
        <property type="gene ID" value="ENSMZEG00005016819.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156421"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055071">
        <property type="term" value="P:manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02085">
        <property type="entry name" value="P-type_ATPase_SPCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000006">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000017">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000106">
        <property type="entry name" value="E1-E2 ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 20" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="811"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="920" mass="100655" checksum="558252A7AC78073E" modified="2019-02-13" version="1">MQKKRELLLSEGEPSSEDETMVPVLTSRKASELPVNEVACVLQADLQLGLTQEEVRRRRAYHGWNEFDISEDEPLWRKYLSQFKDPLILLLLASAVISIIMHQFDDAISITVAIIIVVTVAFVQEYRSEKSLEELGKLVPPECHCVREGNLEHLLARELVPGDTVCLSVGEKVPADLRLFEATDLSVDESSLTGETTPCTKSTAHQPASTNGDIASRSNIAFMGTLVRYGKAKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSLYSFCIIGVIMLVGWLQGKSLLDMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIIKKLPIVETLGCCNVICSDKTGTLTKNEMTVTQLFTSDGQHAEVTGVGYNGQGEVLLNGEVIHGFSCQSISKIVEVGCVCNDSIIRNHNVLGRPTEGALIALAMKVGLEGLQREYVRVEEHPFSSEKKWMAVRCVHRTQQDKAGVYFMKGAYEQVIRFCSSYNSRGSALPLNHQQVELYQQQISYMGSGGLRVLAFASGSEMGKLTFLGLVGIIDPPRSGVKEAVGTLISSGVTIKMITGDSQETAMSIASRIGLFSKGGQSLSGEEVDQLDLQQLSQIISKISVFYRASPRHKLKIVKSLQNNGAVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVCFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDRDIIRKPPRNVGDSIITRSLIVKVLVSAFIIVCGTLYVFWRELQDNVITPRDTTMTFTCFVFFDMFNALSSRSQTRMVHEMGLCSNRTFCFAVLASIMGQLLVIYFPPLQSVFQTESLSVLDLVFLVSLTSSVCAVSEVIKKVERWRGVEKSPPSDFFHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CK80</accession>
    <name>A0A3P9CK80_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead box Q1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FOXQ1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CK80"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022715"/>
    <dbReference type="Ensembl" id="ENSMZET00005023465.1">
        <property type="protein sequence ID" value="ENSMZEP00005022715.1"/>
        <property type="gene ID" value="ENSMZEG00005017006.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162937"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20034">
        <property type="entry name" value="FH_FOXQ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000071">
        <property type="entry name" value="Forkhead box F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047518">
        <property type="entry name" value="FH_FOXQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF385">
        <property type="entry name" value="FORKHEAD BOX Q1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FORK_HEAD_1"/>
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    </dbReference>
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    <dbReference type="PROSITE" id="PS50039">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="47"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="47"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="275" mass="30794" checksum="333C5E4260DC29E8" modified="2019-02-13" version="1">MDSKAGVPSPLSGDELGSDGDCVANSPAPVTQSSDGGKGKPYTRRPKPPYSYIALIAMAIRESSSGRLTLAEINDYLMKKFPFFRGSYTGWRNSVRHNLSLNDCFLKVLRDPSRPWGKDNYWMLNPHSEYTFADGVFRRRRKRISKRPLKEQESPDILSEDTRLPAPEERVGAKFSSPFAIDSILGTPFKRREERSCVEQPGPRLYWSPVAHVLPYNLNYPAQHTYMSEAAYSGTEPGRDAPTYLQHTASGTAAPEATFKMPSKARGFHIESLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKF5</accession>
    <name>A0A3P9CKF5_9CICH</name>
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        <submittedName>
            <fullName evidence="5">Peroxisomal biogenesis factor 11 gamma</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_014269069.2">
        <property type="nucleotide sequence ID" value="XM_014413583.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKF5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022519"/>
    <dbReference type="Ensembl" id="ENSMZET00005023268.1">
        <property type="protein sequence ID" value="ENSMZEP00005022519.1"/>
        <property type="gene ID" value="ENSMZEG00005016873.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101468294"/>
    <dbReference type="CTD" id="92960"/>
    <dbReference type="GeneTree" id="ENSGT00390000000427"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026510">
        <property type="entry name" value="PEX11C_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20990:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="243" mass="27429" checksum="69BBC6C78AA2CBD7" modified="2019-02-13" version="1">MQRCLESLVQLLESYRGRDKVIRTVCYGSQLVGGVLSRRAEADVRSQRLGKSLLLFSAQLSHCRTVLRLFDDLSMLAYSHSYGFGNGEEDAAVRWISVLNNVADQLYYPCEHIAWAADAELIRVKSDKWWLFSTVLWGTSLLLGILRSLRVLLLLRKKLKKRHEGRNSRSQLRRQMRGELLSILSSMADLSNAIHWMPPGFLWAGRFPNWLVGLMGTTSSLIGLIQMNAGSGDQSDTTQSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKJ2</accession>
    <name>A0A3P9CKJ2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Si:ch211-113d22.2</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
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        <lineage>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKJ2"/>
    <dbReference type="Ensembl" id="ENSMZET00005023086.1">
        <property type="protein sequence ID" value="ENSMZEP00005022341.1"/>
        <property type="gene ID" value="ENSMZEG00005016742.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010398"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="CDD" id="cd23553">
        <property type="entry name" value="TFP_LU_ECD_Ly6PGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000037">
        <property type="entry name" value="Si:ch73-28h20.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035076">
        <property type="entry name" value="Toxin/TOLIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036:SF14">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6D-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00087">
        <property type="entry name" value="Toxin_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018092202" evidence="3">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Snake toxin/toxin-like" evidence="4">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="126" mass="13209" checksum="5DAA8AFCAFA93447" modified="2019-02-13" version="1">MKTALAVLLLISLACHSHALKCHTCVASNEEDCNRQGSTTCPQYADACSTITGPNTVMKSCTYKAFCDKANSGTSGAKMHCCFGDDCNGPHKSHSHGGHHNSTGAISSSPVLLITALLLRMALSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CL11</accession>
    <name>A0A3P9CL11_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NFKB inhibitor interacting Ras-like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561084.1">
        <property type="nucleotide sequence ID" value="XM_004561027.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CL11"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022739"/>
    <dbReference type="Ensembl" id="ENSMZET00005023489.1">
        <property type="protein sequence ID" value="ENSMZEP00005022739.1"/>
        <property type="gene ID" value="ENSMZEG00005017026.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471493"/>
    <dbReference type="KEGG" id="mze:101471493"/>
    <dbReference type="CTD" id="28512"/>
    <dbReference type="GeneTree" id="ENSGT00940000159705"/>
    <dbReference type="OrthoDB" id="10002389at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032484">
        <property type="term" value="P:Ral protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042227">
        <property type="entry name" value="KBRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="192" mass="21473" checksum="0E63672578078A22" modified="2019-02-13" version="1">MGKGCKVVVCGQAAVGKTAILEQLLYGNHSVGSESNETQEDVYVASVETDRGVKEQLRLYDTKGLNDGQDLPKHYYSVADGFVLVYSVDSLESFKRVDVLKKEIDKSRDKKEVMVIVLGNKTDLRERRQVEHEAAQQWARGEKVKLWEVSVTERTSLIEPFTQLTSRLTQPQSKSAFPLPGRKSKGSPSNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CL55</accession>
    <name>A0A3P9CL55_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Importin 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CL55"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023068"/>
    <dbReference type="Ensembl" id="ENSMZET00005023825.1">
        <property type="protein sequence ID" value="ENSMZEP00005023068.1"/>
        <property type="gene ID" value="ENSMZEG00005017273.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075074"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="896"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117211" checksum="20788ACD1B676C89" modified="2019-02-13" version="1">MTEELEQILSQLTQPDNAIIQQATAQLKQAFKDPAIIPGLCAVMSGSQNPQIRQSAAVMLRLRVKKHWKKISPNDRESLKAVVLQAFMQETEHTVQHSLSQLCAVMVKHETPDRWPALLQLLNQSTKSSNPHDRQVGLLLLNKVIESNPEPFKPHYCQLLQLLRSVLEDHNNPTALYYCILTLTAITEFIGTEEMHLMRSILPNLIVALKCLIKADQNQASEAMEVFNELMESEVSVIVPHVADVVRFFLEVGSDTNLSDSLRVKALSCVTFLIKLKSKTVLKQKLLSPILQAIFPVLTAAPPPGEQDPEDEEDDSGDGTDNESPKHCAAQIIDTMALHMPPEKLFQQLMPLTQTCLASENPYQRKGGLMCLAVLAEGCADHIRTKILKSVLQTVCQSLSDSSEVVRSAGLFALGQFSEHLQPEVSTYCSELMPLLLGYLSSLNQAKVGHVTKAFYALENFMENLGADIEPYLPTLMETMLSALNNTDNLKIKELAVSAIGAIANAAKELLVPYFTPVIESLKGFLTTTTEEMRSLQTQSLDTLSVLARTIGKDVFSPLAAECVQLGLNLTNTIDDPDLRRCTYSLYSAVSIVTPDCLTPHLTAITTVMLYALKSSEGVTAHLEEDKAFVLLDDDDDENDEKDTEIFLEDDKGTDIHDVAGFSVENAYIDEKEDACEALGEIAFNAGCSILSYFSPQFPHEDVRRAAFGAMGQFCRAQHKVWKENPTEANQQALLKLLDIVVPCFLETVRREPERHVVMGVLESMNSVIKSCKEEVFKNPSRLKEISHAIRDVLKKKTPCQDSGGDEADDEDQQAEYDAMLQEFAGEGIPLVAASVPADNFFPFLNDLLPFIMNKAKSSCTVADRSFSVGTIAEILHALMSVSGGRGVAGRLSNRLLPVLVAGAKDSDPEVRNNSVFGLGCLAQAAGPIVVSDYPMMLSVFSNLLSKESDLRVIDNLCAALCRMIMSNVDAVPLEQVLPALVARLPLKEDQEENNTVFSCLAMLYTHSPALVQSKPHLHLFTFPIQNISVALMQKFAQNHSAEFQAAVTSLPAEQRDSLSAAITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMG7</accession>
    <name>A0A3P9CMG7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Cell membrane</location>
            <topology evidence="1 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMG7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023538"/>
    <dbReference type="Ensembl" id="ENSMZET00005024312.1">
        <property type="protein sequence ID" value="ENSMZEP00005023538.1"/>
        <property type="gene ID" value="ENSMZEG00005017609.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154840"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000106">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF8">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 22" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 22" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="943"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="974" mass="107180" checksum="C631C19F4AD7E543" modified="2019-02-13" version="1">LVMGLSSSRAKEILARDGPNALTPPPTTPEWVKFCKQLFGGFCMLLWIGAFLCFVAYSIQAASEDEPASDNLYLGIVLSVVVMITACFSYYQEAKSSRIMDSFKNMVPQQALVIRDGEKKSINTEEVVLGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPELSNENPLETRNIAFFSTNCVEGTARGIVINTGDNTIMGRIATLASSLEAGKTPIAIEIEHFIHIITGVAVFLGVSFFILSVILGYNWLEGIIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGASFDRSSATWAALSRIAGLCNRAVFLAEQNKVPVLKRHVAGDASEAALLKCIELCCGSVSDMREKYPKIAEIPFNSTNKYQLSIHKNNTPGETKHLLVMKGAPERILDRCSTIVIQGKEQPLDAQLKDSFNSAYLELGGLGERVLGFCHYNLSDDQFPEGFAFDADDMNFPTENLCFIGLMSMIDPPRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIARGVGIISEGNETVEDIAARLNIPVSEVNPREAKACVIHGSELKEMTPEQLDDVLKHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASILTGVEEGRLIFDNLKKSIAYTLTSKIPEMSPFLFFVLFDIPLALGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNAQTDKLVNERLISMAYGQIGMMQALGGFFTYFVILSENGFLPKDLVGIRVFWDNRYLNDLEDSYGQEWTYERRKIVEFTCHTAFFTSIVIVQVADLLICKTRTNSIVKQGMKYVCTDIHEISNNNRLWNRHFPNKPANKSSFNEISLCCFIDSYIYLFHRNYVLIFGIFEEMALAAFLSYCPGMDIAIRMYPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMP2</accession>
    <name>A0A3P9CMP2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cation-dependent mannose-6-phosphate receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004550810.1">
        <property type="nucleotide sequence ID" value="XM_004550753.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMP2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023309"/>
    <dbReference type="Ensembl" id="ENSMZET00005024070.1">
        <property type="protein sequence ID" value="ENSMZEP00005023309.1"/>
        <property type="gene ID" value="ENSMZEG00005017448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468482"/>
    <dbReference type="KEGG" id="mze:101468482"/>
    <dbReference type="CTD" id="4074"/>
    <dbReference type="GeneTree" id="ENSGT00390000002109"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000008">
        <property type="entry name" value="Cation-dependent mannose-6-phosphate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000296">
        <property type="entry name" value="Man-6-P_rcpt_cation_dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF29">
        <property type="entry name" value="CATION-DEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00715">
        <property type="entry name" value="MAN6PRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="17">
        <location>
            <begin position="35"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="283" mass="31553" checksum="D38431AE9C389BED" modified="2019-02-13" version="1">MKVFSSCRGISFLMWIMAFHLVLSVSGVYSVKSTKDCKLLSHSPLQQKVLERLEPLVGKNFTAEDKASNESYTYVFQLCGDAGGAPNAGVIQVDKKTQKTTVIGKYTHTQAIGGSDWVMLIYTNGEKYDAHCNKEERKAIIMISCDRNVKVSKLEVGLEEREKEENCFYLFELDTSSVCPVIESKLSTGSIISTGSIILIIGFSLLAVYLVGGFLYQRVIVGAKGVEQFPNYAFWVEFGNLAADGCDFVCRSRKREESPAYRGEATDNLQEEPEERDDQLLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMU4</accession>
    <name>A0A3P9CMU4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Twitchin</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMU4"/>
    <dbReference type="Ensembl" id="ENSMZET00005024430.1">
        <property type="protein sequence ID" value="ENSMZEP00005023655.1"/>
        <property type="gene ID" value="ENSMZEG00005017696.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234530"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF127">
        <property type="entry name" value="NITR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018152490" evidence="8">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="144"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="239" mass="26533" checksum="B731FCF28264DD3E" modified="2019-02-13" version="1">MIRRLLSLILLSTLWDEDPFQSSITVTKLGDNVTLTCKIPRDDVGLSYWYKLKFGNMIETIASGSFDKISLKGPFNNSRFNATKVGDIYSLTITNATKEDEATYLCQGGMAYKMEFFNSTLLVVDGNKSFTVKQTSDVESVHLGDTMTLQCSLLSENKDDTDQCPDEDKVHWFKGASESHPGSIYHGSLRNKEDGRCDYSLSKTVTNSSDAGTYYCAVVTCGQILFGEGTVVEIGMYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMX2</accession>
    <name>A0A3P9CMX2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SPT2 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563433.2">
        <property type="nucleotide sequence ID" value="XM_004563376.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMX2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023379"/>
    <dbReference type="Ensembl" id="ENSMZET00005024144.1">
        <property type="protein sequence ID" value="ENSMZEP00005023379.1"/>
        <property type="gene ID" value="ENSMZEG00005017500.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101471218"/>
    <dbReference type="CTD" id="144108"/>
    <dbReference type="GeneTree" id="ENSGT00940000154133"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054552">
        <property type="entry name" value="SPT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22878">
        <property type="entry name" value="SPT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPT2 homolog N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="719" mass="78536" checksum="E935A1CB79B0FADC" modified="2019-02-13" version="1">MMDFDNILNIASQNQGLSSVQKRYSLQAGPPKKDPKSKGVNPAAVQALLKKQVTENKKKEWEMKKQKEELLAKRVELKSDRKARAMASRTKDNFKGYNGVPVVEVPKKRRSKHDMQEDDLNGGSFRNNTVDPEDDEDNYEYEQTDSEPESEPEPLRPGRIAGNSSSSSGKTSSKKNNGPPKPPAPSMNFADLLKLAEKKQFEPVDLKPKVVKKEERLRTADEIKELEIERKAKKQDKDKNSKADRGRDGKSQSGYSSSQKNTFEREQKNSRPQKICLEKQSVPSGSIKKSQPTVFNDTGLSFSKLSGSDRERTKLSCSDKEKSKTSLSNSSGVINSKVPSKAMSSQVLAKQGAPKPSSSHKSSTLSDLSFRRESSSLLQGKVSGIPGNRPSCTAGTGQKSKQVSSQQIKPSQGSSSKQGPTNGDPKFGRGEPPRSGMNSAAKSGGNSVMRPSLSGPPKAGSQPQSKTGGTSGSVPKARPGGSGLQGHPGSIVSRPQGSGPGRPGSGGLVPGRPTSSSGLGPGRPKCTVVSETISSKNVGGPRPGMPPRPGMQGMPPRPGMQGMPPRPGMQGMPPRPGMQGMPPRPGMPPRPGMPPRPGMPQRPMMNRPPGPMLPPITSAYKRKYEDEEDEYDSEMDDFIDDGGEVQEEISKHIKEIFGYDRSRYRDESDYALKFMESSWKDLQKEEARSLRMAVQEDLEEERREEEELKRKNVKRKKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CN96</accession>
    <name>A0A3P9CN96_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Cell membrane</location>
            <topology evidence="1 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CN96"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023514"/>
    <dbReference type="Ensembl" id="ENSMZET00005024288.1">
        <property type="protein sequence ID" value="ENSMZEP00005023514.1"/>
        <property type="gene ID" value="ENSMZEG00005017594.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154840"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000106">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF8">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 22" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 22" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="852"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="952"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="984"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="42"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112818" checksum="821222D712D9869B" modified="2019-02-13" version="1">MGSKQMNDDYKLANTSENDDKTTKKGHKSKDTEDLKKEVDLDDHKLSFDELHRKYGTDLTRGLSSSKAKEILARDGPNALTPPPTTPEWVKFCKQLFGGFCMLLWIGAFLCFLAYAIQVASEENPGNDNLYLGVVLSAVVMITACFSYYQEAKSSRIMDSFKNMVPQQALVIRDGEKKSINTEEVVLGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDFSHENPLETRNIAFFSTNCVEGTARGIVINTGDNTIMGRIATLTSSLEAGKTPIAIEIEHFIHIITGVAVFLGLTFFILSVILGYSWLDGVIFLIGIIVANVPEGLLATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVAFQKSSPTWTALSRIAGLCNRAVFLAGQNDVPILKRNIAGDASEAALLKCIELCCGSVSEMREKYPKIAEIPFNSTNKYQLSIHKNTTPRETKHLLVMKGAPERILDRCATIMLDGKEQPLDDELKDAFNSAYLELGGLGERVLGFCHYHLPDDQFKEGFAFDTDDVNFPTENLCFTGLMAMIDPPRAAVPDAVGKCRSAGIKVIMITGDHPITAKAIARGVGIISEGNETVEDIAARLNVPVSEVNPRDAKACVIHGGELKDMTLEEIDDVLRNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASILTGVEEGRLIFDNLKKSIAYTLTSKIPEMSPFLLFVIANIPLPLGTVTILCIDLGTDLVPAISLAYEQAESDIMKRQPRNASDRLVNERLISMAYGQIGMIQASAGFFTYFVVLAENGFLPLDLMGLRIFWDNRFLNDLEDSYGQEWTYESRKILEFTCHTAFFSSIVIVQVADLLICKTRRNSILQQGMKNNVLIFGMFEELALAVFLSYCPGMDIALKMYPMKPLWWFCGLPHGFLLFFYDEIRKYILRHHPGGWLEKETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNK0</accession>
    <name>A0A3P9CNK0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chimaerin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Chimerin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">GTPase-activating protein for p21-rac.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570185.1">
        <property type="nucleotide sequence ID" value="XM_004570128.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004570186.1">
        <property type="nucleotide sequence ID" value="XM_004570129.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012779831.1">
        <property type="nucleotide sequence ID" value="XM_012924377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CNK0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023923"/>
    <dbReference type="Ensembl" id="ENSMZET00005024708.1">
        <property type="protein sequence ID" value="ENSMZEP00005023923.1"/>
        <property type="gene ID" value="ENSMZEG00005017904.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479218"/>
    <dbReference type="KEGG" id="mze:101479218"/>
    <dbReference type="GeneTree" id="ENSGT01030000234635"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001565">
        <property type="term" value="F:phorbol ester receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021623">
        <property type="term" value="P:oculomotor nerve formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04372">
        <property type="entry name" value="RhoGAP_chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10352">
        <property type="entry name" value="SH2_a2chimerin_b2chimerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000005">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chimaerin"/>
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        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035840">
        <property type="entry name" value="Chimaerin_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017356">
        <property type="entry name" value="CHN1/CHN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037860">
        <property type="entry name" value="RhoGAP_chimaerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF1">
        <property type="entry name" value="N-CHIMAERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038015">
        <property type="entry name" value="N-chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1 9" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SH2" evidence="12">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="205"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="14">
        <location>
            <begin position="268"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="459" mass="52992" checksum="C1681CAF35B9CA9D" modified="2019-02-13" version="1">MALNVFDHDEYRPPVWKSYLYQLQQEAPHPRRVTCTSEVENRPKYYGREFHGMISREEADQLLSQAEGSYLIRESQRQPGTYTLALRFGNQTRNFRLYHDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNQEPTLKKHLPHSQEEPDGPTPAKDDHNTEERLTSLVRRATLRESDLAPKYEKVHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKVVPNDCQPDLRHVKKVYSCDLTTLVKAHNTKRPMVVDMCIQEIEARGLQSEGLYRISGFSELIEDVKLAFDRDGEKADISSNAYEDINIITGALKLYFRELPIPLITYDAYPRFIEAAKITDPEKRLEALHEALKLLPPAHCETLRYLMGHLKRVTQYEKENLMTSENLGIVFGPTLMRAPELDAMTALNDIRYQRLVVESLITNEDVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRI9</accession>
    <name>A0A3P9CRI9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PARP12-like CCCH zinc finger tandem domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CRI9"/>
    <dbReference type="Ensembl" id="ENSMZET00005025238.1">
        <property type="protein sequence ID" value="ENSMZEP00005024436.1"/>
        <property type="gene ID" value="ENSMZEG00005018268.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234982"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057602">
        <property type="entry name" value="Zfn-CCCH_PARP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF15">
        <property type="entry name" value="ZINC FINGER CCCH TYPE DOMAIN CONTAINING 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25261">
        <property type="entry name" value="zf-CCCH_PARP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP12-like CCCH zinc finger tandem" evidence="6">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="162" mass="18326" checksum="D6D4D4F96F7B46C0" modified="2019-02-13" version="1">METEILKMICAGQGAVNTEDLVYNLFSGDPTKLSEIICNQEKFVSCCPNGQPKVVARTRLRLCRVKDCPGTCRGLHLCKNFLFSGFCQFTQLRRGCSFSHELTSDHNQRLLRQHELESLSREELCTLLLQSDHTLLPAVSLNLTHDKSTLTKYFRLNSSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CT90</accession>
    <name>A0A3P9CT90_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VLIG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.</text>
    </comment>
    <dbReference type="Ensembl" id="ENSMZET00005026414.1">
        <property type="protein sequence ID" value="ENSMZEP00005025585.1"/>
        <property type="gene ID" value="ENSMZEG00005019094.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163472"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030383">
        <property type="entry name" value="G_VLIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058641">
        <property type="entry name" value="GVIN1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057365">
        <property type="entry name" value="URGCP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796:SF6">
        <property type="entry name" value="INTERFERON-INDUCED VERY LARGE GTPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22796">
        <property type="entry name" value="URG4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25496">
        <property type="entry name" value="URGCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25974">
        <property type="entry name" value="URGCP_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25683">
        <property type="entry name" value="URGCP_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51717">
        <property type="entry name" value="G_VLIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VLIG-type G" evidence="9">
        <location>
            <begin position="571"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="951"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1527" mass="175124" checksum="86528CB8992E7284" modified="2019-02-13" version="1">MFLYRLMMLDYRARCILVRTDSLEMAYLNPTVSEITETDDGDLEALLRTSVDTHEKEQTPLHPMDVQMAVYHCSDSFLKQIIIAKLAQCQYALPLLVPDPVSKEIVCPLWTFRQITKSWKVTQIEPDSQIVTMKNIPVYKAQTPLVSFFRLGSLSVSKSQLMNTLLNDRHSTFFHRNCLGSIKSRHLMDGVAEIAWYCPAGKPNDAFNDCIAFCNLHGDALSLQEQCEILIEKSSINIFLVETLQKNKESSSFIATLFKSKKSLICVTVDDCYDVKTKNGKYIIGLKDKNQADVSEQLKKIIREVLSSPDGSNLKPFFHLETMAELSGTRVDESDPACQRGKSAALQIMNLLTKDNMDVSKIKDEFLAVQGQLWCDWCKIHKQLFHLRGEIEKERSQKQQELMRIRQKQCAASCSKLMELFIGSLSSLPPIDKEYFLKWTQILIDALSTNYLSLILRSYNTTWSEVLVLKSKHDKSDLLLRKQAELEGISKKLQSASFGLEHIFREMGQLYEAHREIQQERNNTDWSKYPELAAQLMISGYPMELMDGDAGHVPLTWISSLLEEVIKKLGDQRVFVLSVLGLQSSGKSTMLNTMFGLQFAVSAGRCTKGAFMQLLKVSEEMQKDFQTDYVLVVDTEGLCALELEGNATPHHDNELATFVVGLGNLTLINIFGENPSEMQDILQIVVQAFMRMKKVHLSPSCVFVHQNVTDVAAAEKNMDGKRRLQEKLDQMTKLAADEEVCDAECFSDVIEFDVQKDVKYCAQLWEGSPPMAPPNPGYSESIQELKDVILSKASKSAGITLSQFKTKVEDLWNALLNESFVFSFKNTLEIAVYRKLEVQYGNWTWALRSKMLTTEEQLHNRIENGDLDKVEKKYLLEETSKTFKEIRKAIKTYFESDKDKEMLTQWRGRFEIKISEFYDEQVSRLKTKLDGVILQKKACKQLDDDKTGFENKLLQKSKELAQQLKDKVRDEEELNKQFNSVWSGWITELTADTKTVVDVNLEEDYCTILQELGFELAFVDESKRRGRYKKISEIGDYSDYLKTSGPKFLGTVVDLYKKYAFSSSFSFKEQQQIRSLIEKAENESLGALKSKPVVTRGYTPTYLHELAKHVKDEVEKFVSERKFALKKDFTVDLLLYVFDRTETWLLESHKKFKMRNDPLTYLESKEAQFSTVFRSFCKGNSSAVVLGELICEKLKASTVEALYNRTAIDLADQMKCNFPAFSGNTLDLEKHILKSLAEKEVFDDFITYIKNPRKHTKAFIAAAVEKYIFKDHKDEAMNLLEKNVLDINSLVSQALFTATHKVQTQGGEADRWLKEFSSALNDKLTLDPICSQNFSDINDFNFLKGEIEKGFAAIIVQMSTMSLENLKESRLKPDEILTDQLCKRCWVKCPFCSAVCINTIEDHSPDDHSVPFHRPNGIQGWHYKGTEELCITFCTTNVSSEGRFYPHHDSEESIPYKQYRTAGSKYATWRITPDGSRLSYWKWFVCRFQNTLEEHYNLKFQGRGEIPDDWKKISKEEAIKSLDEMYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUS4</accession>
    <name>A0A3P9CUS4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prolactin 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the somatotropin/prolactin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUS4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025732"/>
    <dbReference type="Ensembl" id="ENSMZET00005026565.1">
        <property type="protein sequence ID" value="ENSMZEP00005025732.1"/>
        <property type="gene ID" value="ENSMZEG00005019201.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182818"/>
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        <property type="component" value="LG17"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031667">
        <property type="term" value="P:response to nutrient levels"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001400">
        <property type="entry name" value="Somatotropin/Prolactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018116">
        <property type="entry name" value="Somatotropin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417:SF33">
        <property type="entry name" value="PROLACTIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417">
        <property type="entry name" value="SOMATOTROPIN,PROLACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00103">
        <property type="entry name" value="Hormone_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00836">
        <property type="entry name" value="SOMATOTROPIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00266">
        <property type="entry name" value="SOMATOTROPIN_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00338">
        <property type="entry name" value="SOMATOTROPIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018003285" evidence="6">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="230" mass="26136" checksum="54119351F6A8A82C" modified="2019-02-13" version="1">NCPLSLLVSVVLVGLLCLVFCSQPTSLDAAPLCTNAEAGCHVLSLANLFDRVIQHSARMHSISNDLHSEFELYFLPSKNQIGRVSRNCHTSNILTPNGKENAQRMAREELTEVILKLLVAWRDPLWHFHQSMTHFHDFIDFSSNKSLKMSDMVHELRKGVQKVVEKMQMLGILSNSVSSLMSPEAFLAPGSAEWRLMKDYELLYCFRRDSNKVQNYLKILKCRIVPEDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUS8</accession>
    <name>A0A3P9CUS8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUS8"/>
    <dbReference type="Ensembl" id="ENSMZET00005026982.1">
        <property type="protein sequence ID" value="ENSMZEP00005026140.1"/>
        <property type="gene ID" value="ENSMZEG00005019496.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234640"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000024">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052921">
        <property type="entry name" value="GPCR1_Superfamily_Member"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF847">
        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="305" mass="35707" checksum="D2C0118C38F1ECCE" modified="2019-02-13" version="1">MNLTYITFGELHKYRYLYFVVIFTLYILILCFNSIIVYLIWTCKNLHEPMYIFIAALLINSVLYSMIIYPKLLSDVLSEKQTISYPLCLFQGFSYYTSAVSEFLLLAAMAYDRYVSICKPLQYPVIMNRITIYVCVILAWLIPAFEIAVSFVLYSNVKLCSFTLTAIFCNNSFYRLQCVPSVVISIYGVVMLINMTFLPMLFILFSYIRILRISYSCCRETRRKALKTCLPHLLVLINFSCFFFFDIIIVRLESDLSNTVRLTLTFQSILFHPLLNPIIYGLKVNEIFKHIKMLLCQWPSRSLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CWR2</accession>
    <name>A0A3P9CWR2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FAM163B</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_023008331.1">
        <property type="nucleotide sequence ID" value="XM_023152563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CWR2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026778"/>
    <dbReference type="Ensembl" id="ENSMZET00005027636.1">
        <property type="protein sequence ID" value="ENSMZEP00005026778.1"/>
        <property type="gene ID" value="ENSMZEG00005019970.1"/>
    </dbReference>
    <dbReference type="GeneID" id="143412292"/>
    <dbReference type="CTD" id="642968"/>
    <dbReference type="GeneTree" id="ENSGT00400000024875"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="CDD" id="cd20220">
        <property type="entry name" value="PFM_natterin-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053237">
        <property type="entry name" value="Natterin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39244:SF5">
        <property type="entry name" value="NATTERIN-3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39244">
        <property type="entry name" value="NATTERIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="432" mass="49337" checksum="682D9509BF0C2C46" modified="2019-02-13" version="1">MEDSSGIPPTSVNRLMQTNLPLLSVRNFRQKRQVQSSSFVPINGTNLMWVTWNNSLPNHTVSIYNGYTNQVDYICKYKCDAGFYTPSKGRYCSFSSNKRNTIGYKFEILVNKDNFEILEWKADSYGSVPKNSVWTCPGKQIYVGKNQYGLGKVSTKDKVFYLPYKDKEYSYKKYKVLTISENVISQTIYNVRYNNDDSKVFKFPPEVMHEATISNYECHKVVKTVTLSKTYEVQQRWDFAFSVKFGANTTIKAGIPLLVGGTVEVSTEVQFQFTKGATVTESMTDTASVELTVPPNHSCKFSTVRHKEKVDISFTALLRRTYGDGEIHTTSITGTYDNIQIGEIQAVVDRCELLEKFKHCPVQSSSTEQKNAANHTKHNENRKKENRNRRKLRLLSANVNFLENPVESSSSMSNNVNLVFLLLTSFYHFCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYT8</accession>
    <name>A0A3P9CYT8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kazrin, periplakin interacting protein a</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CYT8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027152"/>
    <dbReference type="Ensembl" id="ENSMZET00005028020.1">
        <property type="protein sequence ID" value="ENSMZEP00005027152.1"/>
        <property type="gene ID" value="ENSMZEG00005020252.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154570"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037614">
        <property type="entry name" value="Kazrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059089">
        <property type="entry name" value="Kazrin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776:SF3">
        <property type="entry name" value="KAZRIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12776">
        <property type="entry name" value="KAZRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25986">
        <property type="entry name" value="Kazrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="556"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="642"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="892" mass="100983" checksum="9224192049569198" modified="2019-02-13" version="1">MEEMLTCSRSPFSQVFGRQGQLMQATVQSLNSLNDQIANFMVTGPKSVEQEEHAFPPPEKETLQKSMTLMRHLLVDAQAKILKMMDDNKQLAQRIDGAIQSASQEVTNLRSELSATSRRLAELGATDSSASVLETLQHNHNDPSPHQRQKPPATELCYKTEISSLMDFNSPDASLDKVLLREEVAQLQEEVHLLRQMKDMLNKDLEETQGGCSADVLSATELRVQLAQKEQELDRAKEALQAMKSDRKRLKAEKADLVNQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWDLRRQTKEATEHTGMLRSQLDLKENRIKELEAELAMMSNCVNQRMEFRVFERLVDRDYSPRFMAAKQSLATLTKDVPKRHSLAMPTEAVVNGNNQEWVMQADLPLTAAIRQSQQTLYVHTGHPADRQVAAVRVSPCHSRQPSIISDASALEGDRSSTPSDINSPRHRTHSLCNSLEDLEEAKRKKKKEKMGLGSLSRVFARGKQRKSLDPDSDSLSSPTRLSLSDGSEDQLDRLQQVELARTTPMSLWRAGTVQAWLEVVMAMPMYIRTCSENVKSGKVLLGLTDEDLELGLGVSNLMHRRKLRLAIEDYRDVENGRGLSKAADMDHHWVAKAWLSDVGLPQYSQAFHNHLIDGRVLNSLTRRDLERHLNITKKFHQVSLLLGIELLQLLHFDKEALQARRVQCEHHNVDPLVWTMHRVMKWIRDIDLKEFAESLLNSGVHGAVMVLDPTFNTDTMATVLGISSSKHMVRRHLVEEMKTLIGQASVDAKQEYEHLGLGTPPVLLRQNSLGRPPTSTARHTDEEGSLRRRAVKPPAGFSPKARNGRDLSCHSSYGSLPREVRDHTPPRAEGSPIRGYTSIEVTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2J5</accession>
    <name>A0A3P9D2J5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D2J5"/>
    <dbReference type="Ensembl" id="ENSMZET00005029336.1">
        <property type="protein sequence ID" value="ENSMZEP00005028432.1"/>
        <property type="gene ID" value="ENSMZEG00005021198.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183145"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000002">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000009">
        <property type="entry name" value="WC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF15">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="58"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="169"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="275"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="208"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="239"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="301"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="383" mass="41952" checksum="C0345ACBB034A31B" modified="2019-02-13" version="1">RVLVFLFCSEGLCLSVIVFSLSPPLIMYWVQLFFPPVCDYPITLCVCVCVCVCVCVSIRLAGSGATQCSGRVEIYYNNIWGTVYGNGWDLNEAEVVCRQLNCGTAIQASLSSYYSPEAKQIWLYNVACSGSENSLTQCHYSGWGMRNNYYYYYNYYYYYDAGVICSDLIRLTGSGSTRCSGRVEVYHNNSWGTVCDNGWDLNDAAVVCRQINCGSALEAPQSAHFGEGTGQIWLDDVGCSGNESSLIECNGSGFGTYSCGNHHDADVICSGKKAFKLAGSGSTRCSGRVEIYYNNIWGTVCDDYWDLKDAQVVCRQINCGTALEAPRSALFGAGTGQIWLDNVGCSGNENSLIECKYNQFGTNNCGHQQDAGVICSGEAHFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D385</accession>
    <name>A0A3P9D385_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">USP6 N-terminal like</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005029043"/>
    <dbReference type="Ensembl" id="ENSMZET00005029961.1">
        <property type="protein sequence ID" value="ENSMZEP00005029043.1"/>
        <property type="gene ID" value="ENSMZEG00005021658.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156715"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000010">
        <property type="entry name" value="Putative USP6 N-terminal-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000019">
        <property type="entry name" value="USP6 N-terminal like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF19">
        <property type="entry name" value="USP6 N-TERMINAL-LIKE PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="577"/>
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        </location>
    </feature>
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        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="731" mass="83830" checksum="57725CF9F06CBDCE" modified="2019-02-13" version="1">MLNMQRKRKNHHIHPLLRRIYKGIPLQLRGEVWCLLLDIPKIKEEKKDFYEKLKARARGISPDIRQIDLDVNRTYRDHIMFMHRYDVKQQALFHVLTAYSMYNTEVGYCQGMSQITALLLIYMNEEDAFWALVKLLSGQKHAMHGFFVPGFPKLMRFQEHHDRILKKMMPKLKQHLDNQEVFTSLYTMKWFFQCFLDRTPFTLTLRIWDIYILEGERVLPAMSYTLLKLHKKHLMKLSMEELVEFLQVTLSKDFFCEDDFVIEQLQASMTELRRAKLELPAPGKEDEFPKKPLGQLPPEIAVANHVANGQSHAEPAEPPREPSPLPDPQLDGRPPSRAHRESLEKRIRHHKGDKRETHSRGSERGATPLSAHAIANHNSNAASSSRRDMPGPRWVKPSETKLEALREIQMSRGPSPAPSSPDDTAQPHRRPRSKGYAPGTDRGSNASQYDNVPGLPEQDFEILELEKPPSRLRPFRNEIPYNVSALHQGSPSHGSSLSGTVVSVAPRPRMHSPGRTTTEVPIPHPTQSVDNRLYALPSRYPAPPSALYGERAYATTQRQPNSFSPDKTLMNNTFATYRRQPTHSSARNPRNPRPPLELDNQGSSTPIYLQQLTSTAQVYRFEGHQRGEPNPHYLPAQQGVDGLQWEPTEELPPTSPGGMPRSPSFQKAQMSPLAEFTFPDNPDALRQYRPQLQEQQQHQQPVLRQQLPQLFGGPHYRHAQEAFAMQESMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6R0</accession>
    <name>A0A3P9D6R0_9CICH</name>
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        <submittedName>
            <fullName evidence="6">Synaptopodin-2</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the synaptopodin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6R0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030268"/>
    <dbReference type="Ensembl" id="ENSMZET00005031218.1">
        <property type="protein sequence ID" value="ENSMZEP00005030268.1"/>
        <property type="gene ID" value="ENSMZEG00005022563.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183054"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051976">
        <property type="entry name" value="Synaptopodin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24217:SF9">
        <property type="entry name" value="SYNAPTOPODIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="696" mass="77418" checksum="8E20E23BBDF79397" modified="2019-02-13" version="1">MTMALTLTTGQPTGASNRKGPETGNSKLESSEEGGSSEAPPASVSFGISDEGAEQAEKWNSESDTDLCRPDRQRAKYTRLSRGESQSERHVKETKSKCKRIARLLTDAPNPQNKGALLFKKRRQRVKKFTLVSYGTGDNKVDSEDQIEEGAEEVRSAGYNFVATSDSELEEQYSLYQQQHNLSLNWGSVQEMDALPETKGKGVLMFAQRRKRIDEIVTEHEKLRSEGLPVEVLTEPACEQAQQIYDTEEMYAHADQADQSYMNANLKQHGEYQEDFQDMNHLSNVPKPLVPNRTARPFLGFQDSPSSTPIPGSVVPVTKKHETRFKVPVPINTNPQVWSPTGDIIASRDERISVPAIKTGILPESKQKATNKQSSVRAQYSDLHTQNKGERRSYIDSEEDCFSLGAEACNFMQPRTIKLKNPPPVAPKPTLNPNCPPWMRRSPSSEPNIPPRSPVSQPSHSPVGPHSQNYLQQQDWAQLQQMANRWAPDQTQATLQTPTNAWAPDSSSQLHLQPTTNSWSQQQQRSPGFGRSRSLSLPQRLSSMPSPGHLSPVSTPGVLPIQRQTSFQEKVHKPLTPWEAASRSPIGSVDEAFLFLPSSAATNAKAAKHRGSLPEPPEEWKRRVSLDPAPVSKSHYHHEAPAFHILTKSRTFSPEKPAFYGPPFRPAQPLRASIGQMAQGFSPTKCSPVYSAFQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7Y7</accession>
    <name>A0A3P9D7Y7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7Y7"/>
    <dbReference type="Ensembl" id="ENSMZET00005031435.1">
        <property type="protein sequence ID" value="ENSMZEP00005030474.1"/>
        <property type="gene ID" value="ENSMZEG00005022708.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051287">
        <property type="entry name" value="TCR_variable_region"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367:SF18">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="25"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="145" mass="16284" checksum="1CB71C2252F16EAF" modified="2019-02-13" version="1">MRPLRLQTLDWDTATILHAVIAAIPQLSVNAQKDNVLQAKGEETAAAGGTVTLDCLYNSSSLTNDYLYWYKQDGNNSPKFILMRYSGDQGNTAEEFKERFSSTLDSSIRSVPLKIQKLQLSDSAVYYCALQSETETELLWKHKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8K6</accession>
    <name>A0A3P9D8K6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEAD-box helicase 47</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8K6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030883"/>
    <dbReference type="Ensembl" id="ENSMZET00005031863.1">
        <property type="protein sequence ID" value="ENSMZEP00005030883.1"/>
        <property type="gene ID" value="ENSMZEG00005022989.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155774"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="120"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="419" mass="47164" checksum="2186BA930060656B" modified="2019-02-13" version="1">MPFLFVHFLSSGQSVPDEEEEEEVEEEYTDESDSSDIEDRGPPGTTSPISWPISDYPLQLDHGTARASTHARATDDRTSTTWSTSGTTNEASWSTIWPTSWPPTRFLGWKSPTKIQIEAIPVALQGKDVIGLAETGSGKTVPSLCLSSSRAGLPQRLHTLVLTPTRELAFQISEQFEALGSSIGVKSVIVDVAYFHTSHVCLCSPTVVIHARRLIDHLETQRASLYEILNMDFETESVINLEGIPRERRTFLFSATMTKKVSLESSLKDPVKCRVHTCTCADHVLTVCCDLLKLFYIHGGAVVRNLGITNKRLGALNKFKSKSRSVCWRLTYRGDYIHRVGRTARADDLEILTFYDVELFQRIEKEEVMMLVERVSEAQRFAKIVSHPVFIVSFSVFVRYSLNWKKKTCCVKTMVHKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DBE7</accession>
    <name>A0A3P9DBE7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DBE7"/>
    <dbReference type="Ensembl" id="ENSMZET00005032891.1">
        <property type="protein sequence ID" value="ENSMZEP00005031858.1"/>
        <property type="gene ID" value="ENSMZEG00005023763.1"/>
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    <dbReference type="GeneTree" id="ENSGT00960000186914"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="114" mass="12609" checksum="CF0FAEC706D1B86D" modified="2019-02-13" version="1">MKLLPFILPLNTVILLTRDFHHAIFCLHHQVLSLLSHHFWSQDGWPQVPWPVGAGKCCDVLGQGGHTEGLVKDTAALVPVTKWVPARSPQQPRVTMSHYIGWGRDNGSHGSNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCI0</accession>
    <name>A0A3P9DCI0_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein domain-containing protein</fullName>
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    </protein>
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        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Haplochromini</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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        <property type="entry name" value="DDE_Tnp_1_7"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="101"/>
            <end position="121"/>
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    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="64"/>
            <end position="391"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="30"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="497" mass="57239" checksum="0E64FF1BAB3B375E" modified="2019-02-13" version="1">AALTPKQAKKVKTGKAKPKFKENGSPGVEELWKDRNEEDRNPNPFRFKPARDPGPTFNTTTAWSPLSLFQLFFCENVVRTIIENTNANAAKKRRAGSKFPWTALTVKQVYIFLAILLYIGLVSVHHRADYWRKKWPYNLKPFEAILWSLHLSKYDRLSKIKPLYNQIVTAFKALFQPYKNICIDERMVAYKGRISMKQFMKDKPTKWGYKLFVLADSDTGYTSKSEVSTTYGLSYSAVMDLLHLSLLGQGYILYVDNFYTSLHSSVTYIKKKMAVLALLEKNRQAERGDVRWIRKGELVFVKWTDTREVTMCSTVHKAFSGKTVKQKVKEAAGWTTKAVPVPDCVVDYNKNMGGVDLSDALIGYYTVLHITMKWYKTLFYHFLDIAVVNSFLLHMELCKRQGKEPMTQKMFREQLAKEMLDFAPASALPPPTPLSNLTCMPCYFGSNATDLRRYCWRCQDVGILRVKTPIYCRAYDVALCLTSKNNLTKYHVSYCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCS0</accession>
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            <fullName evidence="14">Circadian locomoter output cycles protein kaput</fullName>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
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        <property type="gene ID" value="ENSMZEG00005023826.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <dbReference type="FunFam" id="3.30.450.20:FF:000016">
        <property type="entry name" value="Circadian locomoter output cycles protein"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047230">
        <property type="entry name" value="CLOCK-like"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
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        <property type="entry name" value="Nuc_translocat"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46055:SF2">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
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    <dbReference type="SMART" id="SM00353">
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
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        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
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        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BHLH" evidence="17">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="275"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="380"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="613"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="751"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="823"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="613"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="882" mass="100048" checksum="2908993ADBF0FE3E" modified="2019-02-13" version="1">LSSFFRDDCSIFDGLMEEDEKDKAKRVSRNKSEKRRRDQFNVLIKELGTMLPGNTRKMDKSTILQKSIDFLCKHKEIAAQSESSEIRQDWKPPFLSNEEFTQLMLEALDGFFIAIMTDGNILYVSESVTSLLEHLPADLVDQNLLNFLPVGEHSEVYKALSTHPSELENLSTDYLKSKNHMEFCCHMLRGAIDPKESPVYEYVKFIGNFKSLSNVPNVTRNGLAGVLQRSLQPAFDDQVCFVATVRLAKPQFIKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLETLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAEQRRELGIEEANPEVTADKSQDSGSESQLNTSSLKEALERFDHSRTPSTSSRSSRKSSSHVSDNTCTSTAPKLHMDTATPPRQSLASTMEMTSQRRSSISSQSMSSQTTGQSVAPGMINQQQQQQQQQQQQQQQQQQQQLQTNVQPVMEFSAQVNAMQHLKEQLEQRTRMIQANIQRQQEELRHIQEQLQRVQGQGIQMLLQQQGGPMNVQLPQVGSVQQTTTLTNQVQQTTINPVHSGTQQLTIQQQAPPTQQSLQQQTNTLMQPQRQTQQASQPQPQPQPQTQGSVSAPLYNTMMISQPGQPNVLQISTSLPQNNTQQGTAVATFTQDRQIRFPAGQQLVTKLVTAPMHACGAVMVPTSMFMGQVVTAYNPFGSQQQGGQTQTLTLQPAQAPQGQPDGQNQTAVVAQSNQQGQQQQQQFLQGPRLLHNNQSTQLILQAAFPLQQQGTFTQATHPQQQQQLQQQQQPQQQQQQQSHHQRHQQQLKPQPQKQQKAPSSHRTDAVSSQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DE30</accession>
    <name>A0A3P9DE30_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Complement component 1, q subcomponent-like 3b</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004542935.1">
        <property type="nucleotide sequence ID" value="XM_004542878.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DE30"/>
    <dbReference type="Ensembl" id="ENSMZET00005034013.1">
        <property type="protein sequence ID" value="ENSMZEP00005032945.1"/>
        <property type="gene ID" value="ENSMZEG00005024542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484294"/>
    <dbReference type="KEGG" id="mze:101484294"/>
    <dbReference type="CTD" id="403002"/>
    <dbReference type="GeneTree" id="ENSGT00940000161639"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000001">
        <property type="entry name" value="Complement C1q B chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF96">
        <property type="entry name" value="COMPLEMENT C1Q-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018304273" evidence="7">
        <location>
            <begin position="26"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="8">
        <location>
            <begin position="133"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="266" mass="27700" checksum="C0D6A2CCE6D62A07" modified="2019-02-13" version="1">MIASGVCGVALVLGLVVLIPVVVNSAGTPARYEMLGSCQMVCDSHGTAATATAKATNPIKDNRLVQSLPTFIQGPQGEPGRVGRMGPRGSMGEPGPPGPAGPPGERGPPGPPGLPGAPGANGPNGAISAATYNTVPKIAFYAGLKKQHEGYEILKFDDVVTNLGNHYDPSSGKFTCSIPGIYFFVYHVLMRGGDGTSMWADLCKNNQVRASAIAQDADQNYDYASNSVVLHLEPGDEIYIKLDGGKAHGGNNNKYSTFSGFMLYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGR4</accession>
    <name>A0A3P9DGR4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGR4"/>
    <dbReference type="Ensembl" id="ENSMZET00005034446.1">
        <property type="protein sequence ID" value="ENSMZEP00005033321.1"/>
        <property type="gene ID" value="ENSMZEG00005024868.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176916"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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</entry>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="Eshel O."/>
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                <person name="Ribeiro F.J."/>
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                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
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                <person name="Swofford R."/>
                <person name="Tan F.J."/>
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                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        <source>
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        </source>
    </evidence>
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</entry>
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    </dbReference>
    <dbReference type="Pfam" id="PF14800">
        <property type="entry name" value="DUF4481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="402" mass="45235" checksum="8C081E91673AA73C" modified="2019-02-13" version="1">MTPEMMEDSNGVCHIVEEREGDVQIQYSRPHARDSINSRPDWSNGQCVASVPSCSMLYPSFNLLRCRAKLEREGFQIPREDMETPLKTALDVPSVRRYMVFNSAQFHFIMAPVLYVVLWCAVFSTLHLYITVSDYWVLCLSVSLISIVLTTAVILILHCSNKEINVNLDIRLVQVNEMLVRHKLLVGVADWVRNCTGNMKLYFVYWDMSPCLRALTETLEELSFATTDTQKKLKSKMSHFVLVTKVSAGESDAEEQDSDEQTPLLENGSAASGRSSNQQKDATATKNYSLVPDAALPSQAKAYQLLMTYSAAYVKLLVSERLSGSSHHRESILKYFQTSPISPDVGAGMTAQRESSKMTQTQTARQPAWPTRGGSWDRVIEERSVQREAKLNDLRDTGSPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMH7</accession>
    <name>A0A3P9DMH7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554562.1">
        <property type="nucleotide sequence ID" value="XM_004554505.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMH7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035397"/>
    <dbReference type="Ensembl" id="ENSMZET00005036648.1">
        <property type="protein sequence ID" value="ENSMZEP00005035397.1"/>
        <property type="gene ID" value="ENSMZEG00005026455.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482041"/>
    <dbReference type="KEGG" id="mze:101482041"/>
    <dbReference type="GeneTree" id="ENSGT00390000016940"/>
    <dbReference type="OrthoDB" id="115781at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF17">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="9">
        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="335" mass="36607" checksum="4F7FED8BBB45B227" modified="2019-02-13" version="1">MALTSLYVTEKPGAGLSEVDICTLEINMKYEVIPSIVCSVCLSFGLIYCFSGYRCFKMVMFFSGFLLSSAAMLLLYHKEPALSTQLQAETKAGIGLGVAVLCGLLTMLMTTVGLLISGLLLGSLLSLSILVVIGQFHSLTPVWVPLSVVLAASMAAAVFTLQWQKLFSIIFTSVFGATAVMLCADYLVGAFVLPDQVYDIFSQAAPRPLCWFDWAVTGICPVLSLTGVLVQWWFTAKGISHNGSAHKKQKKYAKKHANKESRRRPQHHRQRRPPPLKRYAGDVLAPSYLQSLQERQMGTGSSKSTVSTITHTLIDFDFETGSMVPLTTSSPVFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQV2</accession>
    <name>A0A3P9DQV2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metaxin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial outer membrane import complex protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport of proteins into the mitochondrion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with MTX1/metaxin-1. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553554.1">
        <property type="nucleotide sequence ID" value="XM_004553497.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQV2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036627"/>
    <dbReference type="Ensembl" id="ENSMZET00005037912.1">
        <property type="protein sequence ID" value="ENSMZEP00005036627.1"/>
        <property type="gene ID" value="ENSMZEG00005027317.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476330"/>
    <dbReference type="KEGG" id="mze:101476330"/>
    <dbReference type="CTD" id="10651"/>
    <dbReference type="GeneTree" id="ENSGT00950000182919"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03211">
        <property type="entry name" value="GST_C_Metaxin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03079">
        <property type="entry name" value="GST_N_Metaxin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000033">
        <property type="entry name" value="metaxin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF38">
        <property type="entry name" value="METAXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="13">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="14">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="259" mass="29353" checksum="0279F60FF4209E85" modified="2019-02-13" version="1">MSLAAEAFMSQMAAAEPWPENATLYQPLKEDQILLSDCASSLAVQAYLRMCGLPVQVFCRANAEYMSPSGKIPFIHVGNQVVSELGPIVQFTKAKGHSLSDGLDDVQRAEMKAYMELVNNMLLTAELYIQWCDDSTATEISRPRYSSPYSWPLNKILAYQKQWEVRRKMNAIGWGGKTLEQVYEDVSQCCQALSQRLGTQSYFFNKQPTELDALVFGHLFTILTTRLTSTELAERVKSYSNLLSFCRRVEQTYFEDKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRZ2</accession>
    <name>A0A3P9DRZ2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRZ2"/>
    <dbReference type="Ensembl" id="ENSMZET00005038517.1">
        <property type="protein sequence ID" value="ENSMZEP00005037214.1"/>
        <property type="gene ID" value="ENSMZEG00005027736.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183007"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000541">
        <property type="entry name" value="Immunity related GTPase M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF17">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="5">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="169" mass="19532" checksum="05719BB47D9CE2C4" modified="2019-02-13" version="1">MTARIQRYVRDLEETCHIPLRIAITGESGSGKLTFVNAVRGLRNGDEGAAPTGAVEHSKDPIPYFHPEYPNVTLWDLPGVGTLKYPTHKYLEYVGFEKFDFFIIVSDTGCRENDVKLAQEIQKVKKNFYFVHSKIDNFMRDERRNRDFSAERSLTKMRENCVQGEFLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSB2</accession>
    <name>A0A3P9DSB2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSB2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037142"/>
    <dbReference type="Ensembl" id="ENSMZET00005038440.1">
        <property type="protein sequence ID" value="ENSMZEP00005037142.1"/>
        <property type="gene ID" value="ENSMZEG00005027675.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286933"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF129">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="65"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="263" mass="29946" checksum="11DD5DD03483D873" modified="2019-02-13" version="1">MPLATSLAIFQSCNITGVPKSTRCAILRDMVKVRKAERRPPLNKTHKLKRQDWAKKYLKTDFSKVLWTDEMRVSLDGPDGWARGWIGKGQRAPVRLRRQQGGGGVLVWAGIIKDELVGPFRVEDGVKLNSQSYCQFLEDTFFKQWYRKKSASFKKNMIFMQDNAPSHASKYSTAWLARKGIKEEKLMTWPPCSPDLNPIENLWSIIKCEIYKEGKQYTSLNSVWEAVVAAARNVDGEQIKTLTESMDGRLLSVLAKKGGYIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSF5</accession>
    <name>A0A3P9DSF5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">protein-lysine 6-oxidase</fullName>
            <ecNumber evidence="19">1.4.3.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24544"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:12448"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:131803"/>
            <dbReference type="EC" id="1.4.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>lysine tyrosylquinone residue</name>
            <dbReference type="ChEBI" id="CHEBI:20489"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lysyl oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.13" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSF5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037208"/>
    <dbReference type="Ensembl" id="ENSMZET00005038511.1">
        <property type="protein sequence ID" value="ENSMZEP00005037208.1"/>
        <property type="gene ID" value="ENSMZEG00005027731.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157042"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004720">
        <property type="term" value="F:protein-lysine 6-oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000008">
        <property type="entry name" value="Lysyl oxidase homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001695">
        <property type="entry name" value="Lysyl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019828">
        <property type="entry name" value="Lysyl_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF5">
        <property type="entry name" value="LYSYL OXIDASE HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01186">
        <property type="entry name" value="Lysyl_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00074">
        <property type="entry name" value="LYSYLOXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00926">
        <property type="entry name" value="LYSYL_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0186">Copper</keyword>
    <keyword evidence="17 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0886">LTQ</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0801">TPQ</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018071995" description="protein-lysine 6-oxidase" evidence="22">
        <location>
            <begin position="24"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="23">
        <location>
            <begin position="43"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="23">
        <location>
            <begin position="163"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="23">
        <location>
            <begin position="305"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="23">
        <location>
            <begin position="415"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="70"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="343"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038869"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047861"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
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    </evidence>
    <evidence type="ECO:0000259" key="23">
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            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="742" mass="82982" checksum="A111487033FF4933" modified="2019-02-13" version="1">MACSLSFSLFLLVLLSLSCPARAEPRRTTASQRRVSRAPALKVRLAGTFARQAHEGRVEVLHNSTWGTVCDDEVDIKLANVVCRELGFEGGLTWAHSAQYGEGTGPIWMDNVRCDGSEKSLKDCKHNGWGVNDCKHSEDLGVVCTPERRAVSQPASRVRIEEVRLRPILMSTKKKSLMTEGVVEVKHAGRWRQVCDKGWSLNSSRVVCGMLGFPEATQHNVRTYKKIWDTKVEDPSTRLSLMAKKKGFWVEKVHCIGTENSLSECHAQLSIPRSPTPCKNGRHAVVKCVPGPQFARISSGRPQPVRLKVGPRLGEGRVEVLRDGKWGTIVDHLWDRTAASVVCRELGFGTAKDALHGAFMGQGTGPIHMNNVQCTGLEHSILDCYFQEVQPWTFKHSQDASVRCNVPKTGTEKTVRLAGGRVPSEGRVEVLMEVGGRKRWGSVCSENWGITEAMVVCRQLGLGFAASAHQETWYWPGDPSVNDVILSGTHCVGTELSIQQCRRNNHIHCPRGGGAKAAGVSSAPDLVVDAQLVQETAYLEDRPLHLLTCANEENCLSSSAARMNWPYGHRRLLRFSSRIMNLGRSDFRPKASKESWTWHQCHRHYHSIEVFTHYDLLTLNGTRVAEGHKASFCLEDTYCPDGLQKRFSCYNMGDQGISVGCWDTYRHDIDCQWVDVTDVRPGDYIFQVEVNPSLDMAESDFMNNVMRCRCKYDGHRAYMYGCHAGEDTKNLSHQRQITNNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DT03</accession>
    <name>A0A3P9DT03_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DT03"/>
    <dbReference type="Ensembl" id="ENSMZET00005039213.1">
        <property type="protein sequence ID" value="ENSMZEP00005037865.1"/>
        <property type="gene ID" value="ENSMZEG00005028253.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01070000253760"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Si:dkey-16p6.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="781" mass="89094" checksum="2A09B949613A0D03" modified="2019-02-13" version="1">MDALHDAPIRCQDIFKALPDQQRPIRVVLTNGVAGVGKTFSVQKFTLDWAEGLENQHVSVVVLLSFRELNLIRDEQYSLLELLHVFHPTLQKVTAEKLAVSQLLFIFDGLDESRLSLDFTNRKLLSDVTQKSSVSQLLTNLIQGNLLPSALVWITSRPAAANQTPPTCVDRLTEVRGFTDAQKEEYFRRSVSDEELSSRIISHMKTSRSLHIMCTIPVFCWITATVLEHMLTTEQRGELPKTLTDMYSHFLLVQTKRKKNKYHEGVETSPQELTKADGEVLLKLGRLAFEHLETGNIMFYQEDLEQCGLDVTEASVYSGVCTEIFKRECVIFQKPVYCFVHLNIQEFLAAVYMFHCHTNRKTEVLENFLKPKSLTKMFSNFFVNTDLQSLDVFLRRAVEKSLQSKNGHLDLFVRFLHGLCLESNQRLLVGLDEISPDRSINIFHCLMEMNDLSVHQEIQEFLKSENRSKKLLSEIQCSALAFMLQMSEKVLNELDLLKYKTSERGRQRLIPAVRTCRKLKHRCEEQIHQIMTSLCFVFIYIQSVFIMQIFCFYNNTFYIFYHHRLTECGLSESHCKVVASALKSNPSHLTELDMSRNYKLQDSDVKLLCAGLESPNCRLETLRLRGCDLSKISCDYLAAALKSNPSHLRELDLSNNYDLQDPGVKHLCGFLESPGCGLETLRLGRCGLSKISCDYLATVLKSNPSHLRQLDLYDNKLQDSGVKHLCGFLESPGCGLETLSSCELKDLSRNTKCFHSSVAFSYISTTLILIPPVSPVSCFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DT20</accession>
    <name>A0A3P9DT20_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FIIND domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DT20"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037428"/>
    <dbReference type="Ensembl" id="ENSMZET00005038734.1">
        <property type="protein sequence ID" value="ENSMZEP00005037428.1"/>
        <property type="gene ID" value="ENSMZEG00005027906.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111912"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025307">
        <property type="entry name" value="FIIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051249">
        <property type="entry name" value="NLRP_Inflammasome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985:SF2">
        <property type="entry name" value="APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46985">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13553">
        <property type="entry name" value="FIIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23679">
        <property type="entry name" value="UPA-FIIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51830">
        <property type="entry name" value="FIIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIIND" evidence="8">
        <location>
            <begin position="112"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="CARD" evidence="7">
        <location>
            <begin position="400"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54571" checksum="82BCF8890098BDF8" modified="2019-02-13" version="1">MNYSRYQSKSSVSTLSHSLLVTGSPECSNEAKLENPFGASPWQAETHPDVENHTGETPVGTEFNSVSSTLPPSSHLHICSTAFCCLTRSQSHSSLLSNVPRNNLTRAASLPSMKLHEYTPNISVDDFGDETYMFQCSCPGLYQCSVTNLVFVMKGEGDVVYRTVPWNRRLLAQHHKKPAGPLFDITCPQQSVCQLHILHCEVISTGGGQFLQVAHVKEEGIEFIHPHKITKTHAIINIEGFSAYGNVKDEDSPPDPVQSLVLLFYKPPNDCNPRSVLSVFMLPRNIVFPKMRRDRKKSDKTEIYIETTSDCKLHPKQAYTLATDPEHDLVKVKPKQADFQEESFESYFPSFQVFLKEVFTDINLCLRDKSSSTCVWETEVCLFPTGGTTGTVKSLDAGPEKIRRSFIESISGPVLSSLLHHLLEKKVLTIDEVDEAKTVKNRKDKASWVFDTVSRKGGDSEMFEVLREEDPFLYKHLDRRHQNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DV61</accession>
    <name>A0A3P9DV61_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DV61"/>
    <dbReference type="Ensembl" id="ENSMZET00005039539.1">
        <property type="protein sequence ID" value="ENSMZEP00005038131.1"/>
        <property type="gene ID" value="ENSMZEG00005028514.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271898"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001524">
        <property type="entry name" value="Si:dkey-126g1.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029495">
        <property type="entry name" value="NACHT-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14484">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01288">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="86"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005038131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="741" mass="84189" checksum="2FBDEE3C36C4C1F2" modified="2019-02-13" version="1">MCQQNLKSTLKKKFQCVFEGIAKAGNPTLLNQIYTELYITEGGTAEVNEEHEVRQIEKNSRNPDRPEATIRQEDIFKGLPGKEEPKIVLTKGVAGIGKTVLTQKFILDWAEGKANQDIQFIFPFTFRELNVLKEEKFSLVELVHHFFTETKEAGICSFEDFQVVFIFDGLDECRLPLDFHNTELITDPRKSTSVEVLLTNLIRGKLLPSVHLWITTRPAAANQIPSDCVNILTEVRGFTDPQKEQYFKKRFSDDKLSDKVLSHMKTSRSIHIMCHIPVFCWITATVLEDVLKTREGGELPKNLTEMYIHFLVVQTKLSNIKYNQYSKFEPDKHWSPESRKMVESLGKLAFNELQKDNLIFYESDLTECGIDIKEASVYSGVFTQLFREERGLYQDKVFCFIHLSVQEFLAALHVHLTFIKSGINLMEEQQSTFQRENLFYQCSVDKALESPNGHLDLFLRFLFGLSLQSNQILLRGLLTQPGSGSPTKEETVQYIKIKIEEIPCPEKSINLFHCLNELNDRSLVEEIQKSLRSGSLSTDKLSSAQWSALVFILLSSEEDLDVFDLKKYSASEVLLKPDFFSPFLLNMCLFILLCFSRLSGCNLTERSCDALSTILSSPSCRLRELDLSNNDLQDKGVKALSRGLESPHCALETLRSVQYLLLTGCMITHEGCIALASALNSNPSSHLREVDLSYNHPGDTGVKLLAAELNDPHWRIENLRSAITLIKNMKKSSSASTCKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K2CJC3</accession>
    <name>A0A0K2CJC3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ATP6</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="18 19"/>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2015" name="Mitochondrial DNA" volume="1-2" first="0" last="0">
            <title>The complete mitochondrial genome of the Metriaclima zebra.</title>
            <authorList>
                <person name="Chen X."/>
                <person name="Song X.L."/>
                <person name="Chen L.Y."/>
                <person name="Li Y."/>
            </authorList>
            <dbReference type="PubMed" id="26273916"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Hoefler B.C."/>
                <person name="Straight P.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>H(+)(in) = H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Interacts with DNAJC30; interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KT221043">
        <property type="protein sequence ID" value="AKZ87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KT166981">
        <property type="protein sequence ID" value="AKZ87036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009166319.1">
        <property type="nucleotide sequence ID" value="NC_027944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K2CJC3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000007"/>
    <dbReference type="Ensembl" id="ENSMZET00005000023.1">
        <property type="protein sequence ID" value="ENSMZEP00005000007.1"/>
        <property type="gene ID" value="ENSMZEG00005000023.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:26037621"/>
    <dbReference type="GeneTree" id="ENSGT00390000005568"/>
    <dbReference type="OrthoDB" id="5976622at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.220:FF:000004">
        <property type="entry name" value="ATP synthase subunit a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKZ87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AKZ87036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="227" mass="25243" checksum="8F84C68EFDF926A3" modified="2015-11-11" version="1">MMLSFFDQFMSPTYLGIPLIALALSLPWVLYPKPTPRWLNNRLITLQGWFINRFTQQIFQPLSLGGHKWAALLASLMLFLITLNMLGLLPYTFTPTTQLSLNMAFAVPLWLATVIIGMRNQPTHALGHLLPEGTPTLLMPVLIIIETISLFIRPLALGVRLTANLTAGHLLIQLIATAAFVLLPLMPTVAILTAVLLFLLTLLEVAVAMIQAYVFVLLLSLYLQENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AQX1</accession>
    <name>A0A3P9AQX1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AQX1"/>
    <dbReference type="Ensembl" id="ENSMZET00005000104.1">
        <property type="protein sequence ID" value="ENSMZEP00005000074.1"/>
        <property type="gene ID" value="ENSMZEG00005000117.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286922"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16040">
        <property type="entry name" value="SPRY_PRY_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="35"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="226" mass="25680" checksum="D926E026EC6F3DE3" modified="2019-02-13" version="1">MHENKSALIQPSSNFHITYSHLGCQESSSKCQSMINGSITAAELCLFSPSDSCQLIIDTNTVNRHIKLSDNNSKMTHVEEVQSYPDHPDRFDYFYQLMCSTGLTGRCYWEVEWKETVEISVSYRRIRRKGDSYDCVFGWNDHSWSLICSEYGPHYVMYNNRVTFITSSSSPVSNRVAVYVDCPAGSLSFYRVSSDTLIHLHTFNTTFTETLYPGFGFNPGASVSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARG9</accession>
    <name>A0A3P9ARG9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_024658200.1">
        <property type="nucleotide sequence ID" value="XM_024802432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARG9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000032"/>
    <dbReference type="Ensembl" id="ENSMZET00005000057.1">
        <property type="protein sequence ID" value="ENSMZEP00005000032.1"/>
        <property type="gene ID" value="ENSMZEG00005000055.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476691"/>
    <dbReference type="KEGG" id="mze:101476691"/>
    <dbReference type="CTD" id="791187"/>
    <dbReference type="GeneTree" id="ENSGT00940000155264"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000293">
        <property type="entry name" value="SRSF protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000105">
        <property type="entry name" value="SRSF protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000163">
        <property type="entry name" value="SRSF protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF4">
        <property type="entry name" value="SRSF PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="81"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="239"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="653" mass="73695" checksum="D8016C9BE87B5B13" modified="2019-02-13" version="1">MERKVLAMQARKKRTKPRKPGKKPEPHGRGGGSQPGQAESPLPEQDEEILGSDDDEQEDPNDYCRGGYHHVRIGDLFNGRYHVIRKLGWGHFSTVWLAWDIQEKRFVAMKVVKSAEHYTETALDEIKLLKSVRNTDPSDPYREKVVQLLDDFKISGMNGTHVCMVFEVLGYHLLKWIIKSNYQGLPSPCVKSIIRQVLQGLDYLHTKCKIIHTDIKPENILLTVNEPYIKKMAAEATQWQKTGTAPPSGSAVSTAPTSKPTAKMSKNKKKKMKKKQKKQAEMQEKRIHEMEGGALPDTREEEDDEETTENTEDTSSATLSTSATQQDITNHTNADLTPEEQSAHTSGLNEQREVTADDENRMEVNCNGHAATPENETSLEVRGTEQCTEEQEDQQDAKQPESNKETDNAFCDKEERPSCNGNSDTEQQRPPASLSPDSVTVELKEGDKIEEQMDTLKETKRENEEENSQDGATGSMLVNPLDPLNADKLQVKIADLGNACWVHKHFTDDIQTRQYRSLEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIALVIELLGKVPRKLILAGKYSKEFFTKKGDLRHITKLKPWGLFDVLVEKYEWSKEEAHSFSSFLLPMLDLVPERRATAAQCLSHPWLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARY2</accession>
    <name>A0A3P9ARY2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flotillin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FLOT2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Heterooligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557487.1">
        <property type="nucleotide sequence ID" value="XM_004557430.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARY2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000162"/>
    <dbReference type="Ensembl" id="ENSMZET00005000202.1">
        <property type="protein sequence ID" value="ENSMZEP00005000162.1"/>
        <property type="gene ID" value="ENSMZEG00005000153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474030"/>
    <dbReference type="KEGG" id="mze:101474030"/>
    <dbReference type="GeneTree" id="ENSGT00560000077232"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000047">
        <property type="term" value="P:regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904086">
        <property type="term" value="P:regulation of epiboly involved in gastrulation with mouth forming second"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045661">
        <property type="term" value="P:regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000003">
        <property type="entry name" value="Flotillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0967">Endosome</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="87"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="432" mass="47382" checksum="009458AD759AF4CD" modified="2019-02-13" version="1">MGNCHTVGPNEALVVSGGCCGSDQKTYVVGGWAWGWWLVSDIQRITLEIMTLQPKCDDVETAEGVAITVTGVAQVKVMTEKELLGYACEQFLGKSVMEIKSVILQTLEGHLRAILGTLTVEQIYQDRDKFASLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAAVQRDADIGVAEAERDAGIREAECKKEMMDVKFVADTKMADSKRELEMQKASFNQEVNTKKAEAQLAYELQAAKEQQKIRLEEIEIEVVQRKKQIKIEEKEIERTEKELIATVKRPAEAEAYKMQQLAEGQKIKKVLTAQAEAEKIRCIGEAEAASIEAVGKAEAEKMKLKAEAYQQYGDAAKTALVLEALPKIAGKVAAPLSKTNEIVILSGEGSRVTGEVNRLLAELPVSVNALTGVDLTKIPLLQKMTTPQSQAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASI5</accession>
    <name>A0A3P9ASI5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protocadherin gamma-C3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004545486.1">
        <property type="nucleotide sequence ID" value="XM_004545429.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASI5"/>
    <dbReference type="Ensembl" id="ENSMZET00005000649.1">
        <property type="protein sequence ID" value="ENSMZEP00005000578.1"/>
        <property type="gene ID" value="ENSMZEG00005000549.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474376"/>
    <dbReference type="KEGG" id="mze:101474376"/>
    <dbReference type="GeneTree" id="ENSGT00940000163777"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000185">
        <property type="entry name" value="Protocadherin 2 alpha c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF307">
        <property type="entry name" value="PROTOCADHERIN BETA-15-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="30"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="137"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="246"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="354"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="459"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="583"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="806"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="904"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="923"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110089" checksum="F2B41265505B60BE" modified="2019-02-13" version="1">MDHILSRGSWVPVTGLVICLLLCACVVDLVLAQIRYSIPEELEHGAFVGNIAEDLGLDVAKLSARRFRIVSGAKKQYLEVNLENGILFVNEKIDREELCERSPNCFLHLQVVIENPLELYRVEVEILDVNDNSPSFPWSEFNLDITESAAPGSRFPLESAQDQDVGTNSLRSYLLSANEHFALNIQTRNDGSKFAELVLDTPLDREQQKKHEMVLTAYDGGSPERSGTALITITVLDANDNVPVFDRAVYRASLVENAPRGTLVLKLNATDLDEGSNGEVTYAFSGHAPLKVRELFSVDPYMGEIRVKGIVDYEKASVYELYVQAKDRGPSAVAVHGKVLVDILDVNDNAPEVILTSVSTPVQEDAPAGTVIAVISVMDRDSGENGNVDCQIPNNVPFQLHSSFKNYYTLVTSEFLDRETVSEYNITLTARDLGSPSLSTRKTILVQVSDINDNPPRFSQPSYTVYVTENNAPGASICSVTAFDPDSNQNAYLSYSILEGQIQGMPVSTYVSINSDNGNIYALRSFDYEQLRNFQILVQAQDAGFPPLASNVTVNVFVLDQNDNAPVIVSPLPKNGTVATEVVPRAVDAGYLVTKITAIDADAGQNSRLSYQVLQATDPGLFSVALYTGEIRTIRRIVEKDATRQRLVILVKDNGQPPLSATVSIVLTVVDSVPETLSDFGDLTLSPQPPSNLALYLIVSLSTISLIFLVAIIVLAAVKCYKDSETLSGYNLPPLSCCCCGGFQPEPPPEMFKKSNLNLQISSAAKVPTNCMEVNGNSSLSQSYCYKVCLTPESAKSDFMFLKPCSPSSTPRNNEAKSAENSWNAQSRSASVNNGATTPSELKQPNTDWTLTKNQNSSIKSYNSINMDGTLMRKAMHADPENYVTSMAPGQYWTWGTHMRGTKDYKMSPSPSGIPSRPWTPRCTPPPQQQQPSIPSHPHPHPPPDYHHNVYIPGTPSGFCTLRPAAQRSDLDVHNSFSTFGKKRRLQMSPQGETAIINNDLYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZY0</accession>
    <name>A0A3P9AZY0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Trafficking protein particle complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRAPPC5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Golgi apparatus</location>
            <location evidence="2 10">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZY0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003169"/>
    <dbReference type="Ensembl" id="ENSMZET00005003297.1">
        <property type="protein sequence ID" value="ENSMZEP00005003169.1"/>
        <property type="gene ID" value="ENSMZEG00005002457.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101475004"/>
    <dbReference type="GeneTree" id="ENSGT00390000000976"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000005">
        <property type="entry name" value="Trafficking protein particle complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="188" mass="21136" checksum="61D270E8054C1A07" modified="2019-02-13" version="1">MDTRFTRGKSNILERPLTRPKTEVSLSAFALLFSEMVQYCQSRVYSVSELQTRLADMGQSVGASMLDVLVLREKNGKRETKVLNMLLFVKVNVWKSLFGKEADKLEQANDDDKTYYIIEKEPLINAYISVPKENSSLNCAAFTAGIVEAILTHSGFPAKVTAHWHKGTTLMIKFNESVIARDKALDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1W1</accession>
    <name>A0A3P9B1W1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small glutamine-rich tetratricopeptide repeat-containing protein alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-SGT</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Homooligomer. Interacts with DNAJC5 and DNAJC5B. Interacts (via TPR repeats) with HSP90AA1. Interacts (via Gln-rich region) with SLC2A1. Interacts with HSP90AB1. Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct. Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126. Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561587.1">
        <property type="nucleotide sequence ID" value="XM_004561530.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004561588.1">
        <property type="nucleotide sequence ID" value="XM_004561531.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B1W1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003859"/>
    <dbReference type="Ensembl" id="ENSMZET00005004018.1">
        <property type="protein sequence ID" value="ENSMZEP00005003859.1"/>
        <property type="gene ID" value="ENSMZEG00005002995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483311"/>
    <dbReference type="KEGG" id="mze:101483311"/>
    <dbReference type="CTD" id="6449"/>
    <dbReference type="GeneTree" id="ENSGT00940000159037"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000002">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000108">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF3">
        <property type="entry name" value="SMALL GLUTAMINE-RICH TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="17">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="263"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="330" mass="34900" checksum="C88D8E6CE3FAADAD" modified="2019-02-13" version="1">MTDNKRLAFSIIQFLHDQLQSGTLSSDAQESLEVAVQCLETAFEVSTDDQSLAVPMTLPEIFTSATAKYSAQSQVNNNSTPNSPTEEQKAEAERLKSDGNDQMKVDNFAAAVEFYSKAIAINPQNAVYYCNRAAAYSKLGNYAGAVQDCERAISIDPNYSKAYGRMGLALASLNKHTEAVSYYKKALELDPDNDTYKTNLKIAEEKMDTSSPTAGLGGVDLAGLLSNPGFMNMASSLMNNPQVQQLMSGMMSGAYGGVGGGGAGGGGGAAPPPGAAPAAPSAAAPGDLSRLIQAGQQFAQQMQQQNPELIEQLRSQMRNQTPSSGNEEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B229</accession>
    <name>A0A3P9B229_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B229"/>
    <dbReference type="Ensembl" id="ENSMZET00005004095.1">
        <property type="protein sequence ID" value="ENSMZEP00005003934.1"/>
        <property type="gene ID" value="ENSMZEG00005003034.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163991"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
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        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF528">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="253"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="495" mass="54572" checksum="356A1F66E1A80806" modified="2019-02-13" version="1">MIVYSIDTVELQSTSSMVFAIEEINNSTDLLPGIELGYRIYDSCASVPVAVHVAFQFLNRLEAQFNTGKNCSQSGVVMAVVGDSGSTPSITMSQLVSAFNIAQVLTELKKVNFSQNGYDVSFNANGDPVAIYDLVNWQKSGSGIIEIVTVGLYDASLRVGHEFKINRNITWMEDSRKVPVSVCTNSCPPGTRKMLQKGKPICCYDCIACPEGEISNITDSADCLPCHKEFWPNAKRDTCIPKPVEFLSFQDILGIILATFSVLGACLAIIIGAVFFYHRTTPIVRANNSELSFLLLISLTLCFLCSLTFIGAPSEWSCMLRHTAFGITFVLCISCVLGKTIVVLMAFKATLPGSNVMKWFGPPQQRMTVVSFTFIQVLICTVWLVVSPPFPIKNLTTYKEKIILECALGLLASFCFILAVLARKLPDNFNEAKLITFSMLIFCAVWITFIPAYVSSPGKFTVVVEIFAILASSFGLIIFIFAPKCFIILFKPWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2Q9</accession>
    <name>A0A3P9B2Q9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_023010965.1">
        <property type="nucleotide sequence ID" value="XM_023155197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2Q9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004169"/>
    <dbReference type="Ensembl" id="ENSMZET00005004341.1">
        <property type="protein sequence ID" value="ENSMZEP00005004169.1"/>
        <property type="gene ID" value="ENSMZEG00005003233.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153294"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="150"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="281" mass="31755" checksum="C8C5005D0F2A7CB1" modified="2019-02-13" version="1">SCLCLCFCNTLFPFPQPKGKKAKGKKVAPAPSVAKKHEAKKVVNPLFEKRPKNFGIGQDIQPKRDLTRFVKWPRYVRLQRQRSILYKRLKVPPAINQFTQALDRQTATQLFKLAHKYRPETKQEKKQRLLARAEQKAAGKGDAPTKRPPIIRAGVNTVTSLVESKKAQLVVIAHDVDPIELVVFLPALCRKMGVPYCIVKGKARLGRLVHRKTCTSFAFTQINPEDKGALAKLVEAIKTNYNDRYEEIRRHWGGNIMGPKSTARITKLEKAKAKELATKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3B8</accession>
    <name>A0A3P9B3B8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase MRCK alpha</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CDC42-binding protein kinase alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004408"/>
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        <property type="protein sequence ID" value="ENSMZEP00005004408.1"/>
        <property type="gene ID" value="ENSMZEG00005003324.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234517"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
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        <property type="term" value="C:actomyosin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01243">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000010">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000032">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001044">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001055">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031597">
        <property type="entry name" value="KELK"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
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    <dbReference type="InterPro" id="IPR014930">
        <property type="entry name" value="Myotonic_dystrophy_kinase_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF31">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MRCK ALPHA"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08826">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="16 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="77"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="30">
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            <begin position="344"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="27">
        <location>
            <begin position="974"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="25">
        <location>
            <begin position="1044"/>
            <end position="1164"/>
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    </feature>
    <feature type="domain" description="CNH" evidence="29">
        <location>
            <begin position="1190"/>
            <end position="1465"/>
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    </feature>
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        <location>
            <begin position="1539"/>
            <end position="1552"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1576"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="445"/>
            <end position="672"/>
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    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="704"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="889"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1578"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1595"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1654"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1664"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00073692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
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    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1700" mass="192817" checksum="A0EE4F6D75C3A818" modified="2019-02-13" version="1">MSGEVRLKKLEKLILDGPAQSNGQCLSVETLLDILVCLYDECNNSPLRREKNVLEFLEWAKPFTSKVKQMRLHKEDFEILKVIGRGAFGEVAVVKVKNTDKVFAMKILNKWEMLKRAETACFREERDVLVNGDCQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMAKFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPQQITDVSEEAKDLIRRLICSREHRLGQNGIEDFKQHPFFAGIDWDNIRMCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPSHTAFSGHHLPFVGFTYTSKCTLSDRGCLRQLGGEPGKAGQDKLDVEVQRSLEDSLATEAYERRIRRLEQEKLELSRKLQESTQTVQALQHTGEGPLSANKEVEIRSLKSEIDILKKQIADSGQLEKQLEDVTLARRDLEDSSKHIKTLEKQMKSITQERDDLQKDLMDASEKLKVQSKELKEAHSQRKLAMQEFSELNEKLTDLRSAKQRLVRQLRDKEEEMESQNQKVEALRLEVRKAERAKKEMEAQVEEQAAEAQKEKKLKERNEQYSRQLQEELEGLKVKQAGSSAAPAPADQTQEVGRLRGEMEKKTMFFEEELARRGAQYSAELKALRKELRDAESQQLNLQKEILMLKDKLEKTRRESQSEREEFETEYKQEYERERVLLTEENKKLSSELDKLTTMYEKMSSSNRQLEDEMRELADKKESVAHWEAQITEIIQWVSDEKDARGYLQALATKMTEELEGLRSSSLGARATDMPWKMRRLAKLDMSARLELQSALDAEIRAKQSIQDELNKVKANNISTECKLQEVGSKNQELLAEIERLKKETEELRLRRGEHHQDSQNSFLAFLNAPTSALDQFDPKAHQFVVKTFNTPTKCNQCTSLMVGLIRQGCTCEVCNFSCHVTCADKAPAVCPVPQDQTKGPLGIDPQRGIGTAYEGHVRVPKPTGVKKGWQRAMAVVCDFKLFLYELGEGKATQPSVVVSQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSPSSSHKPSILILADSDQERTKWVGLLNELHRILKRNKLKERFVYVPKEAYDSTLPLIKTTQSAAIIDHERVALGNEEGLFVIHVTKDGRICIIRVGDNKKVHHIDLMLQEQLLAVISGRNRHVRLFPSQALDGRETEFYKLAETKGCQTIVSGPVRNGSITCLCVAMKNKIICYEVNKSKMRHRRLRELQAPGPVQWMGLLSERLCVGYPSGFMRYSVHGDMSPVSLLHAEDHTLAFIPQQGLDALCAVEISSKELLLCFSAIGVYVESQGRRSRQQELMWPAVPIAACYNAPYLSVYSENAVDVFDVNTMEWIQTIPVKKVGMRPLNVDGSLNLLGLETVRLIYFRNKMAEGDELVVPETSDNSRKQMVRSMNNKRRYSFRVPEEERLQQRREMLRDPEMRNKLISNPTNFNHVAHMGPGDGIQILKDLPMNVRVQDSRAGFSGSVSIPSITKNRAEPGRSMSASSGLGIRSSSQNGSALRRELSGGSYGSKRQTMTSPSESSLSSGGGVDCGDAPLSQFDREDSDSPRHSTASNSSTFSSPPSPASPHKTKSLSLESTERMGWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3X6</accession>
    <name>A0A3P9B3X6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein tyrosine phosphatase non-receptor type 20</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3X6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004477"/>
    <dbReference type="Ensembl" id="ENSMZET00005004679.1">
        <property type="protein sequence ID" value="ENSMZEP00005004477.1"/>
        <property type="gene ID" value="ENSMZEG00005003474.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160066"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052074">
        <property type="entry name" value="NonRcpt_TyrProt_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900:SF4">
        <property type="entry name" value="FERM AND PDZ DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="174"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="273" mass="32235" checksum="5A90B900D4C4AFB8" modified="2019-02-13" version="1">MSMFILKALEHLKPSDNCLVGKAPENRDKNRYRDILPYDKTRVVVGENQDYINASYIRMQVGDEEFFYISCQGPLPSTVQTFWQMIWENKSDVVSMMTQEVERGRIKCHKYWPEKLGVPLDVGRYQLHLENQQYLEYFHIKIIRMVESETAETHFVRHLKFTHWPDHGVPHSSEQLVRFIRYLRAVHHKGPVTVHCSAGIGRTGVLICTDIILSLIENDFNIVKEMRLQRHGMIQTKEQYLFCYKVWLEVLQGILQLHGSQWQPEDPRDHKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B446</accession>
    <name>A0A3P9B446_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Muscleblind like splicing regulator 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the muscleblind family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B446"/>
    <dbReference type="Ensembl" id="ENSMZET00005004754.1">
        <property type="protein sequence ID" value="ENSMZEP00005004552.1"/>
        <property type="gene ID" value="ENSMZEG00005003492.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182897"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000004">
        <property type="entry name" value="Muscleblind like splicing regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.210:FF:000002">
        <property type="entry name" value="Muscleblind-like 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF4">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
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    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="47"/>
            <end position="73"/>
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    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="183"/>
            <end position="211"/>
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            <begin position="219"/>
            <end position="245"/>
        </location>
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            <begin position="13"/>
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    <feature type="zinc finger region" description="C3H1-type" evidence="13">
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            <begin position="47"/>
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    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004552.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="399" mass="43193" checksum="B0D133ABD538AD8E" modified="2019-02-13" version="1">MALNISSARDTKWLTLEVCRQFQRGNCSRSDEECKFAHPSKSCQIENGRVIACFDSLKGRCSRENCKYLHPPSHLKTQLEINGRNNLIHQKTAAAVLAQQMQLMIPGPSLQPVPTFTQGLGTNAGLGYGSYMTPLSHGMSLIPSDILSSTPVLVPGSSPVSVQCSSSSSSSSSSSPSQKLQRSDKLEVCREFQRGNCARGETDCRFAHPSDSPMIDTTDNTVTVCMDYIKSRCSREKCKYFHPPAHLQAKIKSSQQQINQTAVAAQAAAAAAAVTQSTAKAMKRPLEATVDLAFPHSVLQPLPKRPVLEKSSWASSLLSPSLLHYQQALVSSQTLQQPTAAFYPTGSVLCMTPANGIDHPQVTARNRSQCRVAAVKGPGQPFCKYSVNNTHKIQEAACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B566</accession>
    <name>A0A3P9B566_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B566"/>
    <dbReference type="Ensembl" id="ENSMZET00005005268.1">
        <property type="protein sequence ID" value="ENSMZEP00005005044.1"/>
        <property type="gene ID" value="ENSMZEG00005003906.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234555"/>
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        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled adenosine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14968">
        <property type="entry name" value="7tmA_Adenosine_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001634">
        <property type="entry name" value="Adenosn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF54">
        <property type="entry name" value="ADENOSINE RECEPTOR A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00424">
        <property type="entry name" value="ADENOSINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="28"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU201114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="330" mass="36628" checksum="C3EA837F67784EC4" modified="2019-02-13" version="1">IQIESTMNLGVMIYTLVEVLIAVSCCLGNMLVILALWTTKSIQQPTFCLIASLAMADFLVGCVAIPLAVVVDGWVKTSFNTCLFISCVVILFTLVSVLSLLAISLDRFLRVYIPLRYKRIVTQGHSCLVVAACWIVAIPLSFTPMLGWYNHQTLSNSANSTIVCQFIAVIPMSYLVYFSFFSLNLIPLLVMATLYTHVFCIIKGHLQGKPGSGAQKLSQNYLRKEKKLAGSLALVFALFALCWLPLHIMNCLVYFGEVTNIPPVVLYIGIILSHANSAVNPVVYAFKIQKIKKAYLKIWRKCVSRVAENQESLTSQMTDKRSSSHIVSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B666</accession>
    <name>A0A3P9B666_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Actin, alpha cardiac</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the actin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B666"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005376"/>
    <dbReference type="Ensembl" id="ENSMZET00005005605.1">
        <property type="protein sequence ID" value="ENSMZEP00005005376.1"/>
        <property type="gene ID" value="ENSMZEG00005004157.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156048"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0558">Oxidation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="381" mass="42546" checksum="03FB516530879EF0" modified="2019-02-13" version="1">PTVRKRWKINTTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETAYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6R0</accession>
    <name>A0A3P9B6R0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6R0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005594"/>
    <dbReference type="Ensembl" id="ENSMZET00005005833.1">
        <property type="protein sequence ID" value="ENSMZEP00005005594.1"/>
        <property type="gene ID" value="ENSMZEG00005004318.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162740"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="48"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="87"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31739" checksum="19C981F1ABFC43D7" modified="2019-02-13" version="1">MGTNFKGWGSTWLLYLEELADIVKQHFQIVCYKDFLQNPYCPAAKPWLLRLLPCLKVVASGGVGIDHLDVLFINSLGAKVANTPGVVTRNIHEGHQIATDPKTVHIPQNLMGVEVTRATLGITGMGEVGYKIAQRSKGFEMKVMYHKRTRRDHPLLELPNILITPHIGISTITTARVMVKKMVENAPAGVKGLPVPNEVHLHRQTVKSDFIFRIKISKKVRFEHSKLQDSFNVGSYHMMFDRYRLKNVFEAKLIILLTLYTVRSHRCYQCFHACGVKVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6U1</accession>
    <name>A0A3P9B6U1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EARP complex and GARP complex interacting protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014265620.1">
        <property type="nucleotide sequence ID" value="XM_014410134.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6U1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005634"/>
    <dbReference type="Ensembl" id="ENSMZET00005005878.1">
        <property type="protein sequence ID" value="ENSMZEP00005005634.1"/>
        <property type="gene ID" value="ENSMZEG00005004333.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475815"/>
    <dbReference type="KEGG" id="mze:101475815"/>
    <dbReference type="CTD" id="7260"/>
    <dbReference type="GeneTree" id="ENSGT00730000111137"/>
    <dbReference type="OrthoDB" id="196957at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060341">
        <property type="term" value="P:regulation of cellular localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000156">
        <property type="entry name" value="protein TSSC1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059104">
        <property type="entry name" value="Beta-prop_EIPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040323">
        <property type="entry name" value="EIPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="5">
        <location>
            <begin position="7"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="387" mass="43556" checksum="66D24F730FCF9FC2" modified="2019-02-13" version="1">MEDDAPVIYGLEFQARALTAQTAETDAVRFLVGTQSLKFDNQIHIIDFDDENNIINKNVLLHQAGEIWHIGASPADKAVLTTCYNKTSDSRVVSCAAVWRMPSDWETGNHESPDESAHNPQTLELLCHLDDSTHGNAACVLWEPMGDGKRMISLADNHALLWDLQESSTQATVSSTATLEGKGQLKFTSGKWSPHHNCSQLATANDTAIRGWDLRTMSQIYCIENAHGQLVRDLDFNPNRQYYLASCGDDCKVKFWDVRSVQEPVKTLEEHSHWVWSVRYNHSHDQLVLTASSDSRLILSNMVSISSEPFGHLVDDEELSEGEELHQEDKGKEPLKDSVVSTYEEHEDSVYAAEWSSADPWLFASLSYDGRLVINRVPRALKYRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6V3</accession>
    <name>A0A3P9B6V3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6V3"/>
    <dbReference type="Ensembl" id="ENSMZET00005005851.1">
        <property type="protein sequence ID" value="ENSMZEP00005005611.1"/>
        <property type="gene ID" value="ENSMZEG00005004350.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278447"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF14">
        <property type="entry name" value="BUTYROPHILIN SUBFAMILY 2 MEMBER A2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017997673" description="Ig-like domain-containing protein" evidence="12">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="183" mass="20976" checksum="EA26FB53EB02D5A6" modified="2019-02-13" version="1">MASVELMCCFVLFSVVQVTAEPGDESVVLTCRSTVQPDGAKVVWKDRNERKVHVCQKDSEQPEKQHRRYRNRTEMKKEPLRTGDLSVTLKHPTNTDRDTYTCTVYSREGKELMEKQVELKIKGQCCRYRGLDIVIDSYFVTVRVFVCHTPAVQQLCYTDKHRGHLCSSCQTSLGLPVCSLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBZ5</accession>
    <name>A0A3P9BBZ5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-sensitive inward rectifier potassium channel 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Inward rectifier K(+) channel Kir2.4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Potassium channel, inwardly rectifying subfamily J member 14</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBZ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007419"/>
    <dbReference type="Ensembl" id="ENSMZET00005007730.1">
        <property type="protein sequence ID" value="ENSMZEP00005007419.1"/>
        <property type="gene ID" value="ENSMZEG00005005541.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234586"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000063">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
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        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF53">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 17" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="5 17" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="19">
        <location>
            <begin position="48"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="20">
        <location>
            <begin position="199"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054205"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061031"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081412"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="470" mass="53785" checksum="4F1B189AF1F28500" modified="2019-02-13" version="1">QVPFFPDRYSIVSDTLPEEESTTEQGVMNNYNGKVLTRGSNQVRSRFVKKNGQCNVVFTNMEEKGQRFLADIFTTCVDIRWRYLLAVFCTSFLVSWLFFGLIFYTVALAHGDFEEHPTLKEQAQRMPCILHVQGFIGALLFSMETQTTIGYGWRCVTEECPVAVITVVIQSIVGCIIDSFMIGTIMAKMARPKKRNQTLMFSKNAVIALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIRSYVTAEGEFIPLEQMDLNVGYDEGTDRLFLVSPLVIVHEIDKDSPLYTLSRADLEADDFEVVVILEGMVEATAMTTQFRSSYLSREIFWGHRFEPVIYEDRDRYKVDYARFHKTYEVPSMPHLSAKEATKDLIPMSLNAFCYENEVALSCGEEEDDIFDSSQIVGKERAEERRTSVSVDFQNMFHDNSTVTSGSHNVMCVLDMDNNQMEFDILQTAIPLDPVTYKSEQEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD85</accession>
    <name>A0A3P9BD85_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome 2 open reading frame 42</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005007869"/>
    <dbReference type="Ensembl" id="ENSMZET00005008187.1">
        <property type="protein sequence ID" value="ENSMZEP00005007869.1"/>
        <property type="gene ID" value="ENSMZEG00005005998.1"/>
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        <property type="component" value="LG7"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="C2orf42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029269">
        <property type="entry name" value="Zf-tcix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13518:SF1">
        <property type="entry name" value="C2ORF42 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13518">
        <property type="entry name" value="PUTATIVE TREBLE-CLEF ZINC-FINGER C2ORF42 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="81"/>
        </location>
    </feature>
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        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14952"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="668" mass="72016" checksum="5CB775DB8F01F606" modified="2019-02-13" version="1">METEVCSFSSVLSTPTSQTLTSQANLAAKQRDSRKSSAATPAFLSNLGRATLRGIRKCPQCGVYNGTRGLSCKNKACGVSLRNASSTGRSSRKCAVEVVKVIIDSEVRGGKEQEGQRVLGSGSGGGVQVFSVCHRGRGVTGTQCGFVELVPTDTAIATGDGPTLLTRINLGRCFLPSCKQGQRSNQGESPAAKQSSESLCVHIKQAIECRSFATPLTFKSSVLEGLKASDQVKEELWRLATESPGPLVQRVSKDTLVVKCHTDSHHPLGLLHLTVGAGGPSSEALKSERSIFHCACQVNTRRNKAGVDGAGGSQPPPSSFTLQPCLHFFACVCAFASDEKLASEFSAFLNYASSGLQQKVLGRTISPCEKPLQQAEPVGSHPRAKKLHLDESVSALSVASLSGVGKEGVLASCPRKAGHRKAPGAGGPKAPGSTQAVDEHTVTMGFHQWLASITERIHLAMHYQCDGKPEPLVYHIPQEFFNALQQRLSLGSKKRRLPNFTTAFVRNDGLPQTSYSKYTWHITNLMQVKRIFDTPELPLEVTQSFVKNADGSYSHFRCPEPPPELESLEGCKSDRPQAIRPMELRTFLKVAGAADQKEACPFVIDWIPDVLPRCHVGELRISFEFGHQQSGQPEHGDKTSAAEKGGRNKSDCPQHKLTNTVEILQVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEP9</accession>
    <name>A0A3P9BEP9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Triadin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEP9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008375"/>
    <dbReference type="Ensembl" id="ENSMZET00005008708.1">
        <property type="protein sequence ID" value="ENSMZEP00005008375.1"/>
        <property type="gene ID" value="ENSMZEG00005006392.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000049207"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051282">
        <property type="term" value="P:regulation of sequestering of calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007943">
        <property type="entry name" value="Asp-B-hydro/Triadin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010798">
        <property type="entry name" value="Triadin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14106">
        <property type="entry name" value="TRIADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14106:SF0">
        <property type="entry name" value="TRIADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05279">
        <property type="entry name" value="Asp-B-Hydro_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartyl beta-hydroxylase/Triadin" evidence="11">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="145" mass="15894" checksum="E63268D070C904FD" modified="2019-02-13" version="1">MTEAAEARTSTTTTMVLDHKNGDAGAPPLRVLKKSFTDDFYSTFSSPLAWILVLALIITWSCVFVIMFDLMDYKTISGHPPRRVFKDSGRRGGLSKISSDPMKAVNDAVDESSNIITGIVKFAANLIAPDDDEGTLYAVRKKGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIA6</accession>
    <name>A0A3P9BIA6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sushi repeat-containing protein SRPX2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545798.1">
        <property type="nucleotide sequence ID" value="XM_004545741.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIA6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009650"/>
    <dbReference type="Ensembl" id="ENSMZET00005010009.1">
        <property type="protein sequence ID" value="ENSMZEP00005009650.1"/>
        <property type="gene ID" value="ENSMZEG00005007311.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478836"/>
    <dbReference type="KEGG" id="mze:101478836"/>
    <dbReference type="CTD" id="27286"/>
    <dbReference type="GeneTree" id="ENSGT00940000159149"/>
    <dbReference type="OrthoDB" id="6136178at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000024">
        <property type="entry name" value="Sushi repeat-containing protein SRPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025232">
        <property type="entry name" value="DUF4174"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043555">
        <property type="entry name" value="SRPX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343">
        <property type="entry name" value="HYR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343:SF3">
        <property type="entry name" value="SUSHI REPEAT-CONTAINING PROTEIN SRPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13778">
        <property type="entry name" value="DUF4174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8 15" id="KW-0768">Sushi</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018075050" description="Sushi repeat-containing protein SRPX2" evidence="16">
        <location>
            <begin position="20"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="18">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="18">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="17">
        <location>
            <begin position="162"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="18">
        <location>
            <begin position="246"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="449" mass="50983" checksum="9CAE585E39B2B239" modified="2019-02-13" version="1">MRLSRSVAVFILFFTAGSGTTVYENEFTEEDTTPQLDYTNPYWCHPPGLTNGEVTCHSPRGRAYRSTLGTRCQMSCDRGYKLLGRRSIMCLANRRWSGTAYCRKMRCHMLPLIYHGRYTCTQGFMVDSRCDFTCDTGYRIEGEPSRICQHRGSWSGVQPVCSDTDPPKIKCPPSRLKVAEPGKLTAKVTWDPPTATDTAHKSLDVILVGQEPGTDFKEGLHIIRYKVYDQARNRAACKFIVRVEVRRCPELFPPLHSYLSCSSDGNNYGATCEYHCEGGYERRGVSSRVCQFNRSWGGDPAECVPIEIKADVKTAPALLDQFYEKRRLLIVSAPNMSDPDYQLQNIMTQKADCGLALRHVTVIELLGSPPRETGRIKESLLQPQVIEGLRQAFRISRSYFSMVLLDELGLDRERFISPVGSDELFSYIDSFLLDEEEREKLELRSDFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIW1</accession>
    <name>A0A3P9BIW1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Melatonin receptor 1A a</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549309.1">
        <property type="nucleotide sequence ID" value="XM_004549252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIW1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009646"/>
    <dbReference type="Ensembl" id="ENSMZET00005010005.1">
        <property type="protein sequence ID" value="ENSMZEP00005009646.1"/>
        <property type="gene ID" value="ENSMZEG00005007308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473904"/>
    <dbReference type="KEGG" id="mze:101473904"/>
    <dbReference type="CTD" id="30667"/>
    <dbReference type="GeneTree" id="ENSGT00940000160321"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008502">
        <property type="term" value="F:melatonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000056">
        <property type="entry name" value="Melatonin receptor type 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002278">
        <property type="entry name" value="Mel_1A/1B_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000025">
        <property type="entry name" value="Melatonin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF53">
        <property type="entry name" value="MELATONIN RECEPTOR TYPE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01149">
        <property type="entry name" value="MELATONIN1AR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00857">
        <property type="entry name" value="MELATONINR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="44"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="350" mass="39534" checksum="4B6FA10C718720A5" modified="2019-02-13" version="1">MVMNGSHLNSSLPDPADTVLNRPPWVATTLGCFLIFTTVVDILGNLLVIFSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYVHCQISGFLMGVSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSVCYVLLIWALTVVAIVPNLFVGSLQYDPRVYSCTFVQSASSAYTIAVVFFHFILPIMIVTYCYLRIWILVIQVRRRVKPDNRPKLTPHDVRNFVTMFVVFVLFAVCWAPLNFIGLAVAIKPEVVIPLIPEWLFVASYFMAYFNSCLNAIVYGVLNQNFRREYKRIVVSVCTARIFFQDSSNDAGERLKSKPSPLMTNNNQVKVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ35</accession>
    <name>A0A3P9BJ35_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ETS variant transcription factor 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ35"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009907"/>
    <dbReference type="Ensembl" id="ENSMZET00005010272.1">
        <property type="protein sequence ID" value="ENSMZEP00005009907.1"/>
        <property type="gene ID" value="ENSMZEG00005007459.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158142"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000121">
        <property type="entry name" value="ETS translocation variant 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006715">
        <property type="entry name" value="ETS_PEA3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF181">
        <property type="entry name" value="ETS TRANSLOCATION VARIANT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04621">
        <property type="entry name" value="ETS_PEA3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="8">
        <location>
            <begin position="345"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="489" mass="55085" checksum="8A88C711EED48EC4" modified="2019-02-13" version="1">MDYKMDGYLDQQVPYTLANKSQGNGPLNRLLMAAKRKYMDTELPPQESEDLFQDLSQLQETWLTEAQVPDSDEQFVPDFHSENSVAFHSPPVTIKKEPQSPGSDPSQSCSHKPSFSYPSGEQCLYASAYEQKRAAGGAKSSCPGTPVSPMQQHYSPKPATAGRPDAGYMNPGATSQPLPSNSYPMNASSRFQGPSGDPMCPQFPQPAQAFQRMPSAPAGGGGGVGYHRQHSDPCMPYLQQSFKQEYMDPLYERAAHMLHSHPHRFPPAHMMVKQEPTDYTYEPDVPGCPSIYHHNEGYPNSQHGNEGYLFENDSRVVPEKFEGEVKQEGGGLFREGTPYQRRGSLQLWQFLVALLDDPGNAHFIAWTGRGMEFKLIEPEEVARLWGMQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPEALISLAFPDNQRPSLKAEFERYVNEEDTVPLSHLDEGVPYTPEQAPQNMGPQPYSKGYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJT2</accession>
    <name>A0A3P9BJT2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding protein Musashi homolog 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with RHOBTB2; the interaction is necessary for MSI2 ubiquitination and degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Musashi family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557433.1">
        <property type="nucleotide sequence ID" value="XM_004557376.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004557434.1">
        <property type="nucleotide sequence ID" value="XM_004557377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJT2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010177"/>
    <dbReference type="Ensembl" id="ENSMZET00005010546.1">
        <property type="protein sequence ID" value="ENSMZEP00005010177.1"/>
        <property type="gene ID" value="ENSMZEG00005007676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485192"/>
    <dbReference type="CTD" id="394084"/>
    <dbReference type="GeneTree" id="ENSGT00940000155420"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12323">
        <property type="entry name" value="RRM2_MSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000020">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034126">
        <property type="entry name" value="MSI_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="407" mass="43647" checksum="D1A8761885FD51E1" modified="2019-02-13" version="1">MEGDGSQATSGSLNDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFTDAASVDKVLAQQHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFITFDSEDIVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLSYPNIVATYGRGYTGFAPSYSYQFPGFPATAYGPVAAAAVAAARGSGRGARGRGGYLAYPQSTGPGLPDYGFYSAPSDQRGGPCSFADYGSLGPQAAQMLHSEHATSACNSPLQHLHSPDQFKNPGANPSRPGGFPGANSPGPVADLYGPSSQDSAVGNYISAASPQPGSGFGPSITGPLIATAFTNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BK88</accession>
    <name>A0A3P9BK88_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.21</ecNumber>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartate-based ubiquitous Mg(2+)-dependent phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphoglycolate phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, also has a phosphatase activity toward ADP, ATP, GDP and GTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>sn-glycerol 1-phosphate + H2O = glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:46084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="EC" id="3.1.3.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>sn-glycerol 3-phosphate + H2O = glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:66372"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="EC" id="3.1.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="19">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.21" evidence="8"/>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_023009156.1">
        <property type="nucleotide sequence ID" value="XM_023153388.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BK88"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010337"/>
    <dbReference type="Ensembl" id="ENSMZET00005010708.1">
        <property type="protein sequence ID" value="ENSMZEP00005010337.1"/>
        <property type="gene ID" value="ENSMZEG00005007806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471990"/>
    <dbReference type="KEGG" id="mze:101471990"/>
    <dbReference type="CTD" id="283871"/>
    <dbReference type="GeneTree" id="ENSGT00940000160577"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043136">
        <property type="term" value="F:sn-glycerol 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006114">
        <property type="term" value="P:glycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000123">
        <property type="entry name" value="glycerol-3-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF92">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="306" mass="33211" checksum="57E4E8FDBCD627F4" modified="2019-02-13" version="1">MSVSKCTRLSGALVKQLLDSVDSILFDCDGVIWRGDQAIPGAPQVINLLKEKGKRVFFVTNNSTKSRKMYADKMTALGFDVTEDEVFGTAYCCAMYLKTVCELEGKVYLIGSNAMRQELEAVGIQQTGVGPDHICGKPIDWANVTLDPEVKAVVVGFDEHFSYMKLNRAMQYLTQQGCLFVGTNRDTRLPLEGGKAVAGTGCLLQAVETAAQREARTVGKPNHFMFDCVASQFGVKADRCLMVGDRLDTDILLGSNCGLKTLLTLTGVSTVADAEAHQKSGCPERQGMVPDYYVESIADLLPALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLJ1</accession>
    <name>A0A3P9BLJ1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prostaglandin E2 receptor EP4 subtype</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Prostanoid EP4 receptor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with FEM1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547188.1">
        <property type="nucleotide sequence ID" value="XM_004547131.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLJ1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010793"/>
    <dbReference type="Ensembl" id="ENSMZET00005011170.1">
        <property type="protein sequence ID" value="ENSMZEP00005010793.1"/>
        <property type="gene ID" value="ENSMZEG00005008106.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476595"/>
    <dbReference type="KEGG" id="mze:101476595"/>
    <dbReference type="CTD" id="562469"/>
    <dbReference type="GeneTree" id="ENSGT01050000244902"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004957">
        <property type="term" value="F:prostaglandin E receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071380">
        <property type="term" value="P:cellular response to prostaglandin E stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15142">
        <property type="entry name" value="7tmA_PGE2_EP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000101">
        <property type="entry name" value="Prostaglandin E2 receptor EP4 subtype"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001758">
        <property type="entry name" value="Prost_EP4_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001244">
        <property type="entry name" value="Prostglndn_DP_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF6">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00428">
        <property type="entry name" value="PROSTAGLNDNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00586">
        <property type="entry name" value="PRSTNOIDEP4R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="383"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="449" mass="50292" checksum="D14E99C746D083E2" modified="2019-02-13" version="1">MNNQTTGRTMVPTIPSIMFIFGVVGNLIAIVVLCKSRKEQKETTFYTLVCGLAITDLLGTLLASPVTIAIYVKGAWPGEDPLCQYFGFTMLFFSLAGLSIICAMSVERYIAINHAYFYNDYVDQKLAGLTLVAIYISNAFFCALPIMGFGQVKKQYPQTWCFLEWRSNKTSDAAYSYMYAGFSSLLILSTVICNVLVCVALIRMHRRFVRRMSLGTDVGRSVDPRRRARSFGRLAGAEIQMVILLIGTSVVVLICSIPLVAQVFLNQLYKTPVEVRLDKNPDLRAIRFASFNPIFDPWIYILLRKAVLIKLIEKIKCLFCKMGARRQQRQGNFPCIDAYQLSSVISNRDSNSLVSSDQRDSNSTCQTFLYYKDKTEMCTEKCPKSNKLSASQPPSARNSQASYSSQEGSAEDQTRDKTNAITDHPSSPCPKDPALQVTLNTETVKEKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BM71</accession>
    <name>A0A3P9BM71_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Prickle planar cell polarity protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PRICKLE1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prickle / espinas / testin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BM71"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011027"/>
    <dbReference type="Ensembl" id="ENSMZET00005011408.1">
        <property type="protein sequence ID" value="ENSMZEP00005011027.1"/>
        <property type="gene ID" value="ENSMZEG00005008270.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481198"/>
    <dbReference type="KEGG" id="mze:101481198"/>
    <dbReference type="CTD" id="368249"/>
    <dbReference type="GeneTree" id="ENSGT00940000157529"/>
    <dbReference type="OrthoDB" id="10069167at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09415">
        <property type="entry name" value="LIM1_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09418">
        <property type="entry name" value="LIM2_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09420">
        <property type="entry name" value="LIM3_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09827">
        <property type="entry name" value="PET_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000022">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000035">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033725">
        <property type="entry name" value="LIM1_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033726">
        <property type="entry name" value="LIM2_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033727">
        <property type="entry name" value="LIM3_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033723">
        <property type="entry name" value="PET_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF15">
        <property type="entry name" value="PRICKLE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="14">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="143"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="208"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="618"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="826"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="851" mass="95621" checksum="8EA4578216E7B5B7" modified="2019-02-13" version="1">MSLVSAAGLVAGFQGGARKRDFMMEQKISKLTSGFQRSSTSDDDSGCALEEYAWVPPGLRPEQVQLYFSCLPEDKIPYVNSPGEKFRIKQLLYQLPPHDNEVRYCQSLSEEEKKELHMFSVQRKKEALGRGTVKLLPRNFLNSICDHCGENINGGEMAVFASRASAGLCWHPSCFVCSTCRELLVDLIYFYHDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFSCFECETILGGQRYIMKDGRPYCCGCFESLYAEYCEACGEHIGVDHAQMTYDGLHWHATESCFSCAHCKTSLLGSPFLPYQGRIYCSKACSLGEDVHASDSSDSAFQSARSRESRRSVRIGKSSRSADQCRQSLLFSPSVNYKFPGLSGNANDTLTNKLAHMNLSDEHFWRGRGDENEAPDDQEEEWAEHEDYMTQLLLKFGEQGVFQQASDSRPTDFWIAEKDTKSKQVSSKAGSNGGGGRGSLASKKYQADMYWAQSQDGLGDSAYGSHPGPASSRKIQELELDHGAGGGFQGEEPQWYTDSLECITDEFKKTDQNVRDSMDSLALSNITGTSVDGDNKERSMVYSLQGFHELETEDCEKTSNMGTLNSSMLHRSANSLKSLASEQEEVENVLAEAPQEDRPKPHVPALRRTRSQSRPQQVKFSDDVVDNGYYGDIQVRQPPMSERTRRRVYHFEEQGQDLHSGRQQHHHRRRRSRKSRSDNALNLLPKERPQMCNKADRRGNALGSKGHQPFHGHPHSAAMSDYRLQGQAMGRFLGLYDDDDDDWCSTCSSSSSDSEEEGFFLGQPIPQPRPHRHYYTDDLPSSVAGMSSAPYGQWTKSKKKKGHKGKNCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNB1</accession>
    <name>A0A3P9BNB1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Src homology 2 domain containing transforming protein D, b</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004555044.2">
        <property type="nucleotide sequence ID" value="XM_004554987.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004555046.1">
        <property type="nucleotide sequence ID" value="XM_004554989.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004555047.1">
        <property type="nucleotide sequence ID" value="XM_004554990.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004555048.1">
        <property type="nucleotide sequence ID" value="XM_004554991.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004555049.1">
        <property type="nucleotide sequence ID" value="XM_004554992.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNB1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011447"/>
    <dbReference type="Ensembl" id="ENSMZET00005011820.1">
        <property type="protein sequence ID" value="ENSMZEP00005011424.1"/>
        <property type="gene ID" value="ENSMZEG00005008584.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005011831.1">
        <property type="protein sequence ID" value="ENSMZEP00005011434.1"/>
        <property type="gene ID" value="ENSMZEG00005008584.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005011846.1">
        <property type="protein sequence ID" value="ENSMZEP00005011447.1"/>
        <property type="gene ID" value="ENSMZEG00005008584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486422"/>
    <dbReference type="KEGG" id="mze:101486422"/>
    <dbReference type="CTD" id="564537"/>
    <dbReference type="GeneTree" id="ENSGT00940000159004"/>
    <dbReference type="OrthoDB" id="5914531at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09945">
        <property type="entry name" value="SH2_SHB_SHD_SHE_SHF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000021">
        <property type="entry name" value="Putative SH2 domain-containing adapter protein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF33">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING ADAPTER PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="320"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="420" mass="47616" checksum="271ABCA089D50F19" modified="2019-02-13" version="1">MAKWLKDYLSFGKKVPPQPPTPDYTESEILKAYRLQRDLDFEDPYEDSENRSRGESGTSEPATPVYGSPMKSSSVDVKSPKHRLIKVDSQELGRTKILLSTISLEDQQEPVVPSAPLAGDTDYSDPFDARLNHRPDPDLRPVPCENNGYMEPYEAQRVITELQRNPGGGQARGGLQLYDTPYEDIRGQCLGLVYGEAQEEGKESSRLPQDDERPADEYDQPWEWKKDNISKAFAEMRELAELPWPAPVGQLEEEHPTKEQVQFDNTEWDRSSSPTERLRPLGPRSSPLAGGGMKFRMPHEGLTMVGERVDPTLPLEKQVWYHGSLSRSEAESLLTLCKECSYLVRNSQANRSDYSLSLRSCQGFMHMKFTQCKDGKYVLGQNSPPFDTIPELIHFYTTHKLPIRGAEHLSLLFPVLVQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BPG8</accession>
    <name>A0A3P9BPG8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Poly(rC) binding protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_024658310.1">
        <property type="nucleotide sequence ID" value="XM_024802542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BPG8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011825"/>
    <dbReference type="Ensembl" id="ENSMZET00005012231.1">
        <property type="protein sequence ID" value="ENSMZEP00005011825.1"/>
        <property type="gene ID" value="ENSMZEG00005008852.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101468716"/>
    <dbReference type="GeneTree" id="ENSGT00940000159711"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22517">
        <property type="entry name" value="KH-I_PCBP4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000002">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000003">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="119"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="288"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="502" mass="52063" checksum="01840E9112AEDE6B" modified="2019-02-13" version="1">MRLPAAESTHTFTHHTTTSSTMSCEQEFGDGAMGVTLTLRLLMHGKEVGSIIGKKGETVKRIREESSARINISEGSCPERIITITGPTDCVFRAFTMITFKLEEDLTALVANGTVTSKPPVTLRLVIPASQCGSLIGKGGSKIKEIRETTGAQVQVAGDLLPNSTEREVTISGSQDAIIQCVKLICTVILESPPKGATIPYRPSPTPGTVLLAGNQVFEASDFGSHPLFSVAQGGVDLQQTYAVQSHYGIPHSELAKLHQLSMQQQGLAPISQSATQVLPGGMEANSQTTSQELLIPNDLIGSIIGRQGTKINEIRQVSGAQIKIGSQIDSTSDRHVTISGTPIAINLAQYLITSCLETAKSTAQSSSMPSPVDLTMSFTQPSPPVSASSSSSSPLAAMGAALPHAQILGAPYAFPLSSLLGVKSIPYLALSTPPASAAAAAAAAAAAIGAPMLPASVQTAAATAAVPVQAHAAAALASYTAKISSSTNGMKKPERQKFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BPL1</accession>
    <name>A0A3P9BPL1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nectin cell adhesion molecule 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004558293.2">
        <property type="nucleotide sequence ID" value="XM_004558236.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BPL1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011883"/>
    <dbReference type="Ensembl" id="ENSMZET00005012291.1">
        <property type="protein sequence ID" value="ENSMZEP00005011883.1"/>
        <property type="gene ID" value="ENSMZEG00005008919.1"/>
    </dbReference>
    <dbReference type="CTD" id="793240"/>
    <dbReference type="GeneTree" id="ENSGT00940000156028"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000298">
        <property type="entry name" value="Nectin cell adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF12">
        <property type="entry name" value="NECTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018314334" description="Nectin cell adhesion molecule 3" evidence="18">
        <location>
            <begin position="34"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="148"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="248"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="553" mass="60877" checksum="3B8AE4CA0BFB63B8" modified="2019-02-13" version="1">MEKRLPLRRTLPSNGLRLLISLLTVYGLTGVSSNQVVVPEKVNAVLGKNITLGCRIEVGPSLSFTQSSWERRLPSGTITLAVFNPEFGTSYSSQYEKRISFVSPSIRDATITLEGVDFTDIGSYTCKVATFPLGNTQASTHVNVLVEPKVYVSAGPTALLDGGNESLVATCIAERGLPEAEVFWETELYGRSEKQSQNEANGITTVHVRYMWQPRSSAQGKTLTCVVRHPALQTEFRIPYMLNVQFAPAVSIMGISKNWYAGQANVKLNCEAKANPAARQFTWTRLDGLMPEGVEISNNSLAFTRPLERNDSGVYHCEVTNDIGTSSQVVNIWVQDPPPTTAAASTTASVLHDTPGTGTAVDRRRSPFTSPTLASLHDSSLGTIVGGAVGGVLFLILLLILGGACYMHQRRTFRGDYYTKQYLGPSDMQKESQLDVLQPHELQEVYGDKTSKGSQDLKPKLGGDIIYPDYTPERKDRDNWVDRGDANRGFKEGNYYPDHYNSQNMHPCGPPVHSPIVNNGSPYLPEDCYDNGTDSDYVSHMDGSVISRREWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BS63</accession>
    <name>A0A3P9BS63_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Histone-lysine N-methyltransferase NSD3</fullName>
            <ecNumber evidence="24">2.1.1.370</ecNumber>
            <ecNumber evidence="25">2.1.1.371</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Nuclear SET domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64452"/>
            <dbReference type="Rhea" id="RHEA-COMP:15539"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.371"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64448"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.370"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with BRD4. Interacts (via KIKL motif) with BRD3 (via NET domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.370" evidence="24"/>
    <dbReference type="EC" id="2.1.1.371" evidence="25"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012770"/>
    <dbReference type="Ensembl" id="ENSMZET00005013214.1">
        <property type="protein sequence ID" value="ENSMZEP00005012770.1"/>
        <property type="gene ID" value="ENSMZEG00005009554.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155355"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140952">
        <property type="term" value="F:histone H3K27 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140946">
        <property type="term" value="F:histone H3K4 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15565">
        <property type="entry name" value="PHD2_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15658">
        <property type="entry name" value="PHD4_NSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15661">
        <property type="entry name" value="PHD5_NSD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20166">
        <property type="entry name" value="PWWP_NSD3_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000004">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000030">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000025">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000106">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000205">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041306">
        <property type="entry name" value="C5HCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047458">
        <property type="entry name" value="PHD4_NSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047527">
        <property type="entry name" value="PHD5_NSD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047453">
        <property type="entry name" value="PWWP_NSD3_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17982">
        <property type="entry name" value="C5HCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 28" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="32">
        <location>
            <begin position="272"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="30">
        <location>
            <begin position="653"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="30">
        <location>
            <begin position="818"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="32">
        <location>
            <begin position="867"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="AWS" evidence="34">
        <location>
            <begin position="1000"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="31">
        <location>
            <begin position="1052"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="33">
        <location>
            <begin position="1176"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="30">
        <location>
            <begin position="1228"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="396"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="470"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="29">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="29">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="961"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00056539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00065976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00066819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00068930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00081740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1338" mass="149262" checksum="582DB722436BC992" modified="2019-02-13" version="1">MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEGTCDTGSDPGEDGGPSYDAALDAEFPYPPSASEDMPQVPNGYPPGLGIYEPQAKFSMYSQFPNGSANGYGAIRSYGDHGLTPHIMTHNLPPPPPLHLPSSSPPPSLVDNTPSSQPTHAPSSASGGVLKKTSSPEIKLKIIKTYQNGKELFESALCGDLLQELQAAQAQRRHERKKEKRKKSARLLLQAQEQSLDTSQTQPGTTGQTEDTHVQPPPKEAPPVPKVHHPSVIQETGFCKEFVIGDLVWSKVGTYPWWPCMVSSDPQMKVHTRINTRGHREYHVQFFGSVAERAWIHEKRIVMYQGKQQFDELQSETLRKTTNPVERHKLMKPIPQRERSQWEVGVGHAEDAFLMTRQERIDNYTFIYVDPDPTEAPPSKKPNIRPEKRSRRSSSSITQQDSPPPVKTWKTAAARKLLPLSITMKRLNVEITKCDWPLIQKKAAASPKKDKEEEKKERVEREGRQPDLGYSSRRSEEGGLQQTSSPGSHHSSPQERKLQRRCVRSRSESERGNDLVPKKKTKKEQVLAEMAPETTLRTGSQKGASEISDACKPLKKRSRASTDVEMASSQYRDTSDSDSRGLNDPQVGLFGKSLDSPAAADADASDTQSVDSGLSRQDSSTSKRDTVCQICEVYGDGLMVCEGDCNKQFHMECLGLSSPPEGRFSCTECRTGNHPCFSCKTVGMEVTRCSVSGCGCYYHEDCVRKLPGTTSSPGGGFSCPQHSCSTCCLERDPQRASKGRLIRCIRCPLAYHTSDSCVAAGSVILTHHIMICSNHGSAKKNGLLSSPVNVGWCFLCARGGKLLCCDSCPASFHPECLEMEMPEGSWSCSDCRAGKKPHYKQIVWVKLGNYRWWPAEICNPRLVPSNIQSLRHDIGDFPVFFFGSHDYYWINQGRVFPYVENDKNFVTGQININKTFKKALEEAARRFQELKAQRESREALKQDRNSRKPPPYKFIKSNKPVGKVQVHVADLSEIQRCNCKPADEHPCSLESQCLNRMLQYECHPQVCPAGDSCENQCFSKRLYAETEVIKTEGCGWGLRTNQALKKGDFVAEYVGEVIDSEECQQRIKRAHENHVTNFYMLTLTKDRVIDAGPKGNSSRFINHSCSPNCETQKWTVNGDVRIGIFALCDIEAGTELTFNYNLHCVGNRRTSCHCGSDNCSGFLGVQPSSAAVTEKEEKARNAKMKQKKRKLRPEGKHTHEYFCFCCGKGGELVMCDRKDCPKAYHLLCLNLTKPPYGRWECPWHDCSVCSNPASSLCDFCPRSFCRDHEAGALTTSSLDDRLCCSSHNPLSPLGFLFQSRFCSPDSGGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSA0</accession>
    <name>A0A3P9BSA0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_004566015.1">
        <property type="nucleotide sequence ID" value="XM_004565958.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004566016.1">
        <property type="nucleotide sequence ID" value="XM_004565959.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSA0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012805"/>
    <dbReference type="Ensembl" id="ENSMZET00005013249.1">
        <property type="protein sequence ID" value="ENSMZEP00005012805.1"/>
        <property type="gene ID" value="ENSMZEG00005009620.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479195"/>
    <dbReference type="KEGG" id="mze:101479195"/>
    <dbReference type="CTD" id="5608"/>
    <dbReference type="GeneTree" id="ENSGT00940000157836"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06617">
        <property type="entry name" value="PKc_MKK3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000158">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF12">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="78"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="359" mass="40271" checksum="1173A60DA067DEED" modified="2019-02-13" version="1">MEGGSEKEGKVFCASPPPHQSKGEMSQSKGGKRKRVLKLPKEAFEQATSTSSVPPRDLDSKACVTIGEKNFEVKADDLEQISELGRGAYGVVDKMRHVPSGLIMAVKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVIEKGLTIPEDILGKIAVSIVKALEHLHSNLQVIHRDVKPSNVLINTQGQVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLKKVSKERPTYTELMQHLFFTSHEAKETDVASFVKVILGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSB4</accession>
    <name>A0A3P9BSB4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptor 22</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSB4"/>
    <dbReference type="Ensembl" id="ENSMZET00005013252.1">
        <property type="protein sequence ID" value="ENSMZEP00005012809.1"/>
        <property type="gene ID" value="ENSMZEG00005009616.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278263"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000084">
        <property type="entry name" value="Probable G-protein coupled receptor 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000116">
        <property type="entry name" value="probable G-protein coupled receptor 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF127">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="398" mass="43830" checksum="E9D3F58A6D0AC938" modified="2019-02-13" version="1">MSGVGLLDGGSEVGVEEGWSTPYPLGFQVSLTTVLMLELVLGFSSNLTVLVLYCAQSNLVDSVSNLVTVNLHVLDILVCVLCLPLTVAVILLPANENGVSSLATLCCFHEACVTFTSVATAVNVLVISLDRYDISVRPASRLLTPRRAALLLATVWALSLAVFFLPFLEGDFFSSRNRTLLCVGGQGYYTGLAMYYHLLLQVPCFFIAVAVMLFTYSRILQALNIRIGSHMMRSTQPQSSFPHSLPHASVSAIIALRRAVRRHRDRRERQRRVLKMSLIIISTFLGCWAPLSAVNVLILCMGPSDSLVRLRLCFLAMAYGTTIFHPLLYAFTRQKLRRALKTRVKKRVVSLLQVDPAPSGGTVIHNSWVEGGGKRKNRKSRVEGSDGTDRCLTEAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTI2</accession>
    <name>A0A3P9BTI2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">tRNA N(3)-cytidine methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50956"/>
            <dbReference type="Rhea" id="RHEA-COMP:12849"/>
            <dbReference type="Rhea" id="RHEA-COMP:12851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74894"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50957"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with SARS1/SerRS; interaction is mediated via tRNA(Ser) and is required for N(3)-methylcytidine methylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_014264944.2">
        <property type="nucleotide sequence ID" value="XM_014409458.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTI2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012931"/>
    <dbReference type="Ensembl" id="ENSMZET00005013377.1">
        <property type="protein sequence ID" value="ENSMZEP00005012931.1"/>
        <property type="gene ID" value="ENSMZEG00005009711.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156679"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000279">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="15">
        <location>
            <begin position="105"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00050646"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="292" mass="33722" checksum="98F1A90F892673AB" modified="2019-02-13" version="1">MALSESGVLRGDINCTHPGKEESKDQANTPTARVLTLGEQERLNGERALVSDFKQMKLEKEAQKNWDLFYKRNTTNFFKDRHWTTREFEELKACREFESQKLVLLEAGCGVGNCIFPLLEDDLNIFVYACDFSPRAVEFVRQNPLYCPDRCCAFQCDLTKDDLMENVPESSVDVITLIFVLSAVHPDKMKLVLENISRVLKPGGFILFRDYGLYDHAMLRFKPGNKLGENFYVRQDGTRSYFFSKEFLAELFEKTGFKCVSNDYVLRETVNKKEGLCVPRVFLQSKFMKPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTK0</accession>
    <name>A0A3P9BTK0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTK0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013278"/>
    <dbReference type="Ensembl" id="ENSMZET00005013730.1">
        <property type="protein sequence ID" value="ENSMZEP00005013278.1"/>
        <property type="gene ID" value="ENSMZEG00005009980.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001618"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48424">
        <property type="entry name" value="DYNEIN LIGHT CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48424:SF3">
        <property type="entry name" value="DYNEIN LIGHT CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="114" mass="12660" checksum="51C48682E6D80F57" modified="2019-02-13" version="1">MATLKQQNGHLTQVEVNEMLRLMSHVTAKVPPNDAVPGWVILLLYLFNICSDVFLDIVLLQGLSGTLHGVLLHVLRHVGIFDHCLSVRHGCPGKPKHSGEFIILTGTLARTQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTN4</accession>
    <name>A0A3P9BTN4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Proheparin-binding EGF-like growth factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014267540.1">
        <property type="nucleotide sequence ID" value="XM_014412054.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTN4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012991"/>
    <dbReference type="Ensembl" id="ENSMZET00005013440.1">
        <property type="protein sequence ID" value="ENSMZEP00005012991.1"/>
        <property type="gene ID" value="ENSMZEG00005009751.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471223"/>
    <dbReference type="KEGG" id="mze:101471223"/>
    <dbReference type="CTD" id="797938"/>
    <dbReference type="GeneTree" id="ENSGT00940000156901"/>
    <dbReference type="OrthoDB" id="8780145at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070654">
        <property type="term" value="P:sensory epithelium regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000158">
        <property type="entry name" value="proheparin-binding EGF-like growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740:SF4">
        <property type="entry name" value="PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00009">
        <property type="entry name" value="EGFTGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="6" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017988466" description="Proheparin-binding EGF-like growth factor" evidence="17">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="239" mass="27021" checksum="9ED82848A2270FC1" modified="2019-02-13" version="1">MRIFAVALLLAHALVMSRLASGAAVDRYQSNKQQHTSVISLLDTTRDRRAEEEENRGVRATTADYSKDGEAEEYDDDYYYYEEYEDGTSGDYELQLPRVAMSSKPKDPSTILEAENTEGKTTRGKGKKRGKGKGRKRNPCLKKYKDYCIHGTCTYLKDLREPSCVCHHNYSGDRCQFILLPSQSREGYDRTTALAVVAVVLSSLCLTIIGLLLMLRFHKRGEYDVENEEKVKLGSASNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTX8</accession>
    <name>A0A3P9BTX8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 24</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562465.1">
        <property type="nucleotide sequence ID" value="XM_004562408.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTX8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013420"/>
    <dbReference type="Ensembl" id="ENSMZET00005013875.1">
        <property type="protein sequence ID" value="ENSMZEP00005013420.1"/>
        <property type="gene ID" value="ENSMZEG00005010058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475476"/>
    <dbReference type="KEGG" id="mze:101475476"/>
    <dbReference type="CTD" id="9862"/>
    <dbReference type="GeneTree" id="ENSGT00390000016438"/>
    <dbReference type="OrthoDB" id="21216at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048484">
        <property type="term" value="P:enteric nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061453">
        <property type="term" value="P:interstitial cell of Cajal differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046549">
        <property type="term" value="P:retinal cone cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021429">
        <property type="entry name" value="Mediator_Med24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12898:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11277">
        <property type="entry name" value="Med24_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="989" mass="110679" checksum="9AD47F56797B1005" modified="2019-02-13" version="1">MKMVNLKQAILQAWKDRWSDYQWAINIKKNFPKGVTWDYLNLAEALMEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLMAISKFDDFSRELCVKSLLEIMDMFCHRLSCHGKTEECIGLCRALLAVVVWLLQGCAWYCEKLRELGPSASTETSLGACQERLQSLMNSTKNRALVHIARLEDQGSWSNVEQAVLNLTDGLSSVTNSKLHTKLEESLSLVKSIPLMLSEQSDPPVYASFPSVHAFIMLEGTMNLTGEIQPLVEQLMMIKRMQRIPAPLFVLEIWKACFTGLIESPEGTEELKWTAFTFLKIPQVLLRLKKYPQSDRGQDFMEDVNIAFQYLLKLTPLLDKADQRCNCDCLGMLLTECNKLGLLSDSNTVNLTSKRTEDREFAPRLKTAENANIQPNPGLILRAEPTVTNILKTVDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIKLNEFPKHISGEGSKSASVRALLFDISFLMLCHVVQTYGSEVILSDPSPSGETPFFETWLQTCMPEEGKTLNPENPCFRPEPGKVESLVTLLNNSSEMKLVQVKWHEICLSIPAAILEVLNAWENGVLSVEAVQKITDNIKGKVCSMAICAVAWLVAHVRMLGRDEREKPQTMIRQLVTPLYGENTLQFYNERVIIMSSIMEHMCADVFQQTGATLRSPVEGQEPIPYRNLLPPKEPIHTALSKQFQAVLRKGWVDSRALHLFESLLNMGGVFWFTNNLVKELLKETRQEWANRVVELLYSIFCLDTQQITLTLLGTILPNLLTDSAHWRSLADPPGKALAKLSVWCALSSYSSHHKGSFSARQRKRQREDIEDYNSLFPLDDTQPSKLMRLLSSNEDEPVALSSPGDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSKMAGPHTQFVQSFMEECVECLEQGSRGSILQFMPFTMVYELVKLPALAKPKVVLAITDLTLPLGRRVAAKAISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BUN5</accession>
    <name>A0A3P9BUN5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004542272.1">
        <property type="nucleotide sequence ID" value="XM_004542215.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004542273.1">
        <property type="nucleotide sequence ID" value="XM_004542216.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BUN5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013663"/>
    <dbReference type="Ensembl" id="ENSMZET00005014131.1">
        <property type="protein sequence ID" value="ENSMZEP00005013663.1"/>
        <property type="gene ID" value="ENSMZEG00005010288.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480342"/>
    <dbReference type="KEGG" id="mze:101480342"/>
    <dbReference type="CTD" id="100128731"/>
    <dbReference type="GeneTree" id="ENSGT00390000016516"/>
    <dbReference type="OrthoDB" id="2124077at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="37" mass="4179" checksum="AADA831D1A98052C" modified="2019-02-13" version="1">MVTDVQLAIFANMLGVSLFLLVVLYHYVAVNNPKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVB3</accession>
    <name>A0A3P9BVB3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Gastrula zinc finger protein XlCGF57.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004565248.2">
        <property type="nucleotide sequence ID" value="XM_004565191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVB3"/>
    <dbReference type="Ensembl" id="ENSMZET00005014386.1">
        <property type="protein sequence ID" value="ENSMZEP00005013915.1"/>
        <property type="gene ID" value="ENSMZEG00005010497.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101468917"/>
    <dbReference type="GeneTree" id="ENSGT01150000286959"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="192"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="619" mass="70589" checksum="9BE2FA3D8B5B2E19" modified="2019-02-13" version="1">MELQTSPSEQRKYKDAKLILERTPQGSTRVDLGLAYSRWAALKRDKCFQTDAELAAFLLDCYESRVTTSSSMNGKPPSVSQCEDSRGTERQLYSKVQSGVSEIENLRPDEPRDDIFVSPTLAKSEESAQIHTRKSLVFPSEDEQVEQDQKDSVLLHIKEEQEELLTSQDGEQLNGLQEADNATLPFSHVVVKSEDEEEKPPCTQLLHSQTEDNAEAERRQISCSTKIKTETDREDSEGAEPAGNPESNNLLQQNTDAKTFTSGETEVSIGADDEDDDTDDWQEPLSDSGSETEESDSDCKKGRAKAFICSECGKWFQYKWSLQRHVTRHSGKASLGSFTNKKCFPVKQTADLQIKVHTGEKPFGCSLCEQRFRDQYNLKRHMRIHTGEKPFGCGICGKRFNGEGNLKIHKRVHTGEKPFGCGVCGRKFKQKSHFKKHIMVHTEERPFSCDVCGKGFKWRIHMKTHRRIHTDEKLFGCDVCGRRYNCERNLKIHMRGHSDERPFGCDICGRRFNCNRNLKIHKKVHTGERPFACGVCGKRFSQVGARNRHRSVHTEEKPFACDLCGQKFNREGNLERHKRVHTGEKPFGCDICGQKFTREGSLKRHMRNKAINHLHTVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BX06</accession>
    <name>A0A3P9BX06_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BX06"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014176"/>
    <dbReference type="Ensembl" id="ENSMZET00005014652.1">
        <property type="protein sequence ID" value="ENSMZEP00005014176.1"/>
        <property type="gene ID" value="ENSMZEG00005010679.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167973"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09401">
        <property type="entry name" value="LIM_TLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000054">
        <property type="entry name" value="Cysteine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074:SF6">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="85" mass="10010" checksum="6BF9779B3863979D" modified="2019-02-13" version="1">MVGYCPICGKPVYFGEKKRSLGRDYHPLCLKCQKCNRQLTPGQHAEYDEKPYCTHCYLKMFGPRGILPSQYENTNTHNWPTTRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY92</accession>
    <name>A0A3P9BY92_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/arginine-rich splicing factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Splicing factor, arginine/serine-rich 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014264427.1">
        <property type="nucleotide sequence ID" value="XM_014408941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BY92"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014611"/>
    <dbReference type="Ensembl" id="ENSMZET00005015094.1">
        <property type="protein sequence ID" value="ENSMZEP00005014611.1"/>
        <property type="gene ID" value="ENSMZEG00005010988.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475211"/>
    <dbReference type="KEGG" id="mze:101475211"/>
    <dbReference type="CTD" id="100145909"/>
    <dbReference type="GeneTree" id="ENSGT00910000144115"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000352">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="81"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="165" mass="19498" checksum="69E836783503862D" modified="2019-02-13" version="1">MHRDCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDATDAVRELDGRTLCGCRVRVELSTGEKRSRTRGAPPSWSRRPRDRDDYRRRSPPPRRRSPRRRSFSRSRSRSFSRDRRRERSLSRDRNHKPSRSFSRSRSRSRSNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYL4</accession>
    <name>A0A3P9BYL4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane BAX inhibitor motif containing 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014265062.2">
        <property type="nucleotide sequence ID" value="XM_014409576.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024661821.1">
        <property type="nucleotide sequence ID" value="XM_024806053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYL4"/>
    <dbReference type="Ensembl" id="ENSMZET00005015211.1">
        <property type="protein sequence ID" value="ENSMZEP00005014726.1"/>
        <property type="gene ID" value="ENSMZEG00005011084.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484830"/>
    <dbReference type="KEGG" id="mze:101484830"/>
    <dbReference type="KEGG" id="mze:112436449"/>
    <dbReference type="GeneTree" id="ENSGT01050000244890"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF35">
        <property type="entry name" value="PROTEIN LIFEGUARD 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="336" mass="36738" checksum="F236D779E4612D30" modified="2019-02-13" version="1">MSNYPPGYEESHGPLYGPQGGNYPPPPPYGFPSYGGSQPGYPSAPYPSGPNAPLYPGQPAGYPPGPYPGQPQPAGHPGSRYPNPPPMPPVVPPTIPSDVLSSGDEFAASGSDWDSLSIRHTFIRKVYLILACQLLVTTAIVAIFTFVQPVKSFVRKNSAVYWASYAVYFITHIVLVCCKGPRRKFPWNMILLGLFTLSLSYMTGTISSYYDTKAVFLALGITAVVCIAVTVFCFQTKVDFTKCQGLFCVLGIVVFVTGIITAIVLSFKYIFWLHMLYAAIGAIVFTLFLAYHTQLLIGNRKHSISPEEYVFAALSIYVDIIQIFLFLLQIIGASTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYU1</accession>
    <name>A0A3P9BYU1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Denticleless E3 ubiquitin protein ligase homolog (Drosophila)</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYU1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015153"/>
    <dbReference type="Ensembl" id="ENSMZET00005015643.1">
        <property type="protein sequence ID" value="ENSMZEP00005015153.1"/>
        <property type="gene ID" value="ENSMZEG00005011361.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064210"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="554" mass="60319" checksum="81B84A56520B6745" modified="2019-02-13" version="1">GMLFRSVVDRGVGRRRSPVQVPLSSLLEGYRCVRHDEHISYGNLGDSVPPFGLAFSSARDLQNILAAANEEGIVRLYNTESREYPLLKAWLAHENAVFDIAWMPGEPQLVTAAGDQMARLWDVKSGELLGSFKGHLYSLKSVAFAPEEKAVFSTGARDGNIMIWDMRCSKKDGFYRQVNQISGAHNKAETNPPSKTKKRRGGMRGMAPSVDSQQSVTVVLFRDQHTLISSGAVDGVIKMWDLRKNYTAHRHDPVPLQTFPYPGSCTRTRLGYSGLALDSARANVMCNCTDDSIYMFSVCRIKTTPVAVFSGHQNSSFYVKSSVSPDDQFLASGSSDNHTYIWKISNPELPPMTLQGHSEEVTSVAWCPTDFTKIASCSDDHTVRIWRLHRENDEVQSSLGEANLVGHARPKILPSKPSIPAETTPAKPQRRVRLGGIASPQPAACAPSGATLPLSSSTTTPNRSQDSKTAAVRHRTPPTIKQWLSPSSRTSEQAGSPAHRVLSQSPQSSASSTPPQNDGPNAEKYGIICDWLTLVSGIKVVGGPRSSLASSSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C176</accession>
    <name>A0A3P9C176_9CICH</name>
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        <submittedName>
            <fullName evidence="10">Transmembrane and coiled-coil domain family 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
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    <dbReference type="RefSeq" id="XP_004544795.1">
        <property type="nucleotide sequence ID" value="XM_004544738.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012917575.2"/>
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        <property type="nucleotide sequence ID" value="XM_012917576.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012917577.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMZET00005016512.1">
        <property type="protein sequence ID" value="ENSMZEP00005016000.1"/>
        <property type="gene ID" value="ENSMZEG00005012020.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101484470"/>
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    <dbReference type="GeneTree" id="ENSGT00940000155189"/>
    <dbReference type="OrthoDB" id="10072335at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF11">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="587"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="389"/>
            <end position="451"/>
        </location>
    </feature>
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            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
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            <begin position="464"/>
            <end position="563"/>
        </location>
    </feature>
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            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
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            <begin position="64"/>
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        </location>
    </feature>
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            <begin position="101"/>
            <end position="113"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="651" mass="70953" checksum="46089C3B2D0F3B04" modified="2019-02-13" version="1">MDQGSSEQSPEEPDAGGRAEPELGRRASESEHGLSKITHNALENMGALGHGLKQFFQPQRRRSSVSPHDSASSCASAPPSEPADVGSEVGDTPASSALPLDSDTPATSAPPAALSRVLQQIRGPPMIKRGTSLQSRRSKAGGTGDPPQKGSPQIHRRSTHEALLQAGRPRSSSTTDTPSSPALADMLLTSGYHSTEEPDKLDRYDASGPAISPNALPYGADGYDVVDSTPDPQRTKQAIAQLQQKILKLTEQIKIEQTARDDNVAEYLKLANNADKQQSARIKQVFEKKNQKSAQTIQQLQRKLEHYHRKLREVEHNGIPRQPKDVFRDMHQGLKDVGAKVTGGLSSFSQATHSAAGAVVSKPKEIANIIRNKFGSADNIAALKDSLDETQGDEGIGPGGARALGTGALPSSPKYPSDDDCSSATSGSAGANSTPGAPGGPPSSKGNTLDHAQASGFDAILHEIQELRENQGRLEESFENLKAHYQRDYTMIMEGLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARTLLGKLINVLLAVMAVLLVFVSTVANCVVPLMKTRSRTLSTLLLVIILAILWRHWDAISEYMHRFLLHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3Q3</accession>
    <name>A0A3P9C3Q3_9CICH</name>
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        <submittedName>
            <fullName evidence="8">Speckle type BTB/POZ protein like a</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563172.1">
        <property type="nucleotide sequence ID" value="XM_004563115.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012922410.2"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005016893"/>
    <dbReference type="Ensembl" id="ENSMZET00005017433.1">
        <property type="protein sequence ID" value="ENSMZEP00005016893.1"/>
        <property type="gene ID" value="ENSMZEG00005012687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474792"/>
    <dbReference type="KEGG" id="mze:101474792"/>
    <dbReference type="CTD" id="541318"/>
    <dbReference type="GeneTree" id="ENSGT00940000155953"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18519">
        <property type="entry name" value="BACK_SPOPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18343">
        <property type="entry name" value="BTB_POZ_SPOPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
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    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
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    </dbReference>
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        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="392" mass="44291" checksum="B109BAA6C7D8460D" modified="2019-02-13" version="1">MSRVPTPPPPGEMSSGPVAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGPNDKMKWCLRVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQSNMNMLKVPECQLSDDLGNLWECSRFTDCSLYVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVDISDVDPDVFKEMMGFIYTGKAPNLEKMADNLLAAADKYALERLKVMCEEALCNSLSVENVADTLILADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNHATDIMETAGWKSMIQSHPHLVAEAFRALASAQCPPFGLPRKRLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8C6</accession>
    <name>A0A3P9C8C6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 11 open reading frame 54</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004557342.1">
        <property type="nucleotide sequence ID" value="XM_004557285.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012776277.1">
        <property type="nucleotide sequence ID" value="XM_012920823.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8C6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018161"/>
    <dbReference type="Ensembl" id="ENSMZET00005018750.1">
        <property type="protein sequence ID" value="ENSMZEP00005018161.1"/>
        <property type="gene ID" value="ENSMZEG00005013643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486898"/>
    <dbReference type="KEGG" id="mze:101486898"/>
    <dbReference type="CTD" id="100711217"/>
    <dbReference type="GeneTree" id="ENSGT00390000017214"/>
    <dbReference type="OrthoDB" id="5119241at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="319" mass="35163" checksum="6BD27EBA4FB9B685" modified="2019-02-13" version="1">MADTSKTEKVQLHAPDLEELRGVLQAGLETNFAEVQVSVVECPDLTKEPFQFPVKGLCGSPRITDVGGVPYLVPLVRKEKEYNMNTVSKELELPGAFILGAAAAPNRIVGMNAELMPLVLTEAGGRPAVNSSYFSSINPADDQCLLEKYSDKFTDCNFGLLGNLYACEGKPGRVIEVQAKRRTGSHSLVTALRTSLEAHYPDKSLALGGTFIIQKGKAKIHIMPREFSVCPLNTNDDVNNWLKHFEVSAPLICQSVLVSRDPGLDLRVEHTHCFSHHGEGGHYYIDTTPDSVEYLGYFMPAEFVYRIDRPKETHGVGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9S2</accession>
    <name>A0A3P9C9S2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9S2"/>
    <dbReference type="Ensembl" id="ENSMZET00005019251.1">
        <property type="protein sequence ID" value="ENSMZEP00005018651.1"/>
        <property type="gene ID" value="ENSMZEG00005014005.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286915"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001524">
        <property type="entry name" value="Si:dkey-126g1.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="568" mass="64591" checksum="8E73BD4B6311D3A6" modified="2019-02-13" version="1">MHRSETTIRLEDIFKGSTGRDEPIRTVLTKGVAGIGKTVLTQKFTLDWAEDKTNQNIEFTFPFTFKELNVLKEKKFSLVELVHCFFTETKKAGICSFEDFQVVFILDGLDECRLPLDFHNTEIFTDVTESTSVDVLLTNLIRGHLFPSARLWITTRPAAANQIPPECVSMVTEVRGFTDQQKEEYFKKRFRDEEQASRIISHIKTSRSLHIMCHIPVFCWITATVLEDVLKTRDEEELPKTLTEMYIHFLVVQAKVKKVKYDGGVETDPHWSPESREMIESLGKLAFDHLQKGNLIFYESDLTECGIDITAASVYSGVFTQIFKEERGLYQDRVYCFIHLSVQEFLAALHVHLTFINSGVNLLALQSPNGHLDLFLRFLLGLSLVTNQILLRGLVTDSESISKASKQTVRYIENKLCENLPTEKIINLFHCLNELNDCSLAETIQLILSLGRLYAYELSPDEWSAVVFILLSSEKDLDVFELKKYQVSERALLRLLPVIKDSKKAVLSGCNLSLRSCEALSSVLNCDSSHLRKLDLSNNNVQDSGVKILSAGLKSSYCRLDSLRSEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CA57</accession>
    <name>A0A3P9CA57_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Proline dehydrogenase</fullName>
            <ecNumber evidence="14">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CA57"/>
    <dbReference type="Ensembl" id="ENSMZET00005019781.1">
        <property type="protein sequence ID" value="ENSMZEP00005019165.1"/>
        <property type="gene ID" value="ENSMZEG00005014359.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006265"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000006">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 14" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="16">
        <location>
            <begin position="155"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="624" mass="71611" checksum="CE067666405EC905" modified="2019-02-13" version="1">MFYVKTVPALKRARADIHFKRLVLNRAVRCTVTSSSTAQTEHDGVRSRGGSECPGLSGRGGRRREGTAAAAAANEISVDFEQTREAYKSKDSLELLRSLVVFKLCSYDFLVDKNKEVMDLAKKILGQKTFDQFMKMTFYGQFVAGEDHNDIKPLIQKNHSYGVGSVLDYSVEEDISQEEAERKEMEYENSIALLNNTIDSTPERKYQAHKQFSDRRGGVTGARTYFYADEAKCDQHMETFIKCIKASGGSSMDGFSAIKMTALGRPQFLLQFSEVLVKWRRFFTFLASQQGKDGLEALEQRLELTQLQEFMTKLGANGDFYGWFTGRKEDSTGCIDMLDWNSLIDDRTKISDLLVVPNVELGKLEPLLGKFTVEEDQQMKRMLQRVDILAKHALESGVRLMVDAEQTYFQPAISRLTLEMQRTYNGEKPVIFNTYQCYLKEAYDNVTMDVELSRREGWHFAAKLVRGAYMYQERERAKEIGYEDPINPDYESTNRMYHRCLDYVLDEIALNRKANIMVASHNEDTVKHTLTRMNELGLIPTENKVYFGQLLGMCDQISFPLGQAGFPVYKYVPYGPVNEVMPYLSRRAQENRGFMKGAQKERELLWKELKRRLASGELLYKPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAU8</accession>
    <name>A0A3P9CAU8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein 62</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014269799.1">
        <property type="nucleotide sequence ID" value="XM_014414313.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAU8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019237"/>
    <dbReference type="Ensembl" id="ENSMZET00005019858.1">
        <property type="protein sequence ID" value="ENSMZEP00005019237.1"/>
        <property type="gene ID" value="ENSMZEG00005014443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487880"/>
    <dbReference type="KEGG" id="mze:101487880"/>
    <dbReference type="CTD" id="80021"/>
    <dbReference type="GeneTree" id="ENSGT00390000016216"/>
    <dbReference type="OrthoDB" id="27234at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07401">
        <property type="entry name" value="MPP_TMEM62_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041871">
        <property type="entry name" value="MPP_TMEM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056230">
        <property type="entry name" value="TMEM62_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24394">
        <property type="entry name" value="TMEM62_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="3">
        <location>
            <begin position="329"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 C-terminal" evidence="4">
        <location>
            <begin position="481"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="659" mass="74888" checksum="56ED9BF2633536AB" modified="2019-02-13" version="1">MHPVWPRWQRQKRRMLKLFGALVILGLALACITSWVLDSYDTAWHPKRSVQHPTVGDEAESKGSSPPFPGEHLNNIFWFVQVSDIHISRFHDPRRIPDFEKFCTDTIEVIKPALVLATGDLTDAKTESKVGSLQHEVEWQAYHNILKRSRVMERTKWIDIRGNHDAFNIISLDSTTNYYRKYSANQKVGSFHYVHTTPFGNYSFVCVDATLTPGPKRPYNFFGILNQTQMDLLDTFRAESLKSNQSIWFGHYTTSTIVSPSSGVRDMMRSAVAYLCGHLHTLGGLMPVLHSRHPQGTLELELGDWMDNRRYRVLAFDHDLLSFSDLRFEQWPAVLITNPKDAQYLHPGVEALGRIRRSTHIRILAFSEAPITAVHVSVDGEPLGKGHSAGGPLYVLLWDPSLYLTGLHTIRVKVEDAAGRSSVREQHFTLEGDLTPTFGFVQSFILLTDHYVLGRVAFIFMMLLNIGVLMAFRFMPILSGRGLTSQVCMSLRLVSKIDTFYYSLLLFNLCTALGPWFIGELIDGHSGACFAFGVFIDGHFLEGSLTYVVGVVQLLFFNMPLTSYLCWSLHHRCRGNTFRSHFLRPGCRWRTLAVHLFMLLLLTWQAHSCYFLLETYGPMAFFLSPVRTWALGLSLLLVYRAWTSPASLIRDTSKSVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CE05</accession>
    <name>A0A3P9CE05_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Anamorsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytokine-induced apoptosis inhibitor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Fe-S cluster assembly protein DRE2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CIAPIN1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer. Interacts with NDOR1. Interacts with CHCHD4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004566181.1">
        <property type="nucleotide sequence ID" value="XM_004566124.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012778707.1">
        <property type="nucleotide sequence ID" value="XM_012923253.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024658872.1">
        <property type="nucleotide sequence ID" value="XM_024803104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CE05"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020480"/>
    <dbReference type="Ensembl" id="ENSMZET00005021136.1">
        <property type="protein sequence ID" value="ENSMZEP00005020480.1"/>
        <property type="gene ID" value="ENSMZEG00005015355.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474357"/>
    <dbReference type="KEGG" id="mze:101474357"/>
    <dbReference type="CTD" id="57019"/>
    <dbReference type="GeneTree" id="ENSGT00390000011417"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000085">
        <property type="entry name" value="Anamorsin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049011">
        <property type="entry name" value="Anamorsin_N_metazoan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20922">
        <property type="entry name" value="Anamorsin_N"/>
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        <ligand>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    </evidence>
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        <source>
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</entry>
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    <accession>A0A3P9CE32</accession>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Venkatesh B."/>
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                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the spectrin family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005020156"/>
    <dbReference type="Ensembl" id="ENSMZET00005020804.1">
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        <property type="gene ID" value="ENSMZEG00005015109.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:spectrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000004">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.58.60:FF:000011">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.58.60:FF:000018">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000019">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000028">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000033">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.58.60:FF:000059">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.58.60:FF:000083">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000099">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.20.58.60:FF:000105">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Spectrin beta chain"/>
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        <property type="match status" value="12"/>
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        <property type="entry name" value="Calponin-like domain"/>
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        <property type="entry name" value="Actinin_actin-bd_CS"/>
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        <property type="entry name" value="CH_dom"/>
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        <property type="entry name" value="CH_dom_sf"/>
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    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
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    <dbReference type="InterPro" id="IPR016343">
        <property type="entry name" value="Spectrin_bsu"/>
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    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002297">
        <property type="entry name" value="Spectrin_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00150">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1980"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="885"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1996"/>
            <end position="2007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002297"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2007" mass="233387" checksum="8D110A6FC1D7A2BA" modified="2019-02-13" version="1">MDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKRSAKDALLLWWTAWPSTPDLIDFDKLKKSNAHYNLQNAFNLAEHHLGLTKLLDPEDISVDHPDEKSVITYVVTYYHYFSKMKALKVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLAGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRMELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLQAVEAATKKHEAIETDIAAYEERVQAVVAVAKELEAERYHDIKRIAARKDNVIRLWEYLLELLKARRQRLEMNLGLQRVFQEMLYIMDWMDEMKMLLLSQDYGKHLLGVEDLLQKHALVEADIAIQADRVKAVTANANKHSASNSGYKPCDPQVIQDRVAHLEFCYQELTQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEQILSSLEHGKDLTGALRLLSQQRALEDEMSGRAGHLQHTIAEGQAMVKAGHFGATKIQERISDLQAQWAALEQLAAVRKKRLEEALALHQFQADADDVDAWMLDALRIVSSGETGHDEFSTQALARKHKDAAAEVASYRPVIDSLHEQVACLPKEEAESEEVRGRLTCIEERYKEVADLTKLRKQALQDALSRYKMFSEADACEVWIDEKEQWLNSMEIPEKLEDLEVIQHRFESLEPEMNSQASRVAVVNQIARQLMHSGHPSEKDIKTQQDKLNNRWSLFRELVDRKKESLNSALGVQNYHLDCNETKSWIKEKTKVIESTQELGNDLTGVMALQRKLTGMERDLAAIEDKLSEMHGEARRLAEEHPDQANAITGRLAEITAVWEEMKNTLKNREESLGEARKLQQFLRELDDFQSWLSRTQTAIASEDMPNTLAEAEKLMAQHEGIKNEIQNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQLFLRDTKQAEAFLNSQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEDKINGVVEAGRRLASDGNINGDRIHEKVTSIDDRHKKNREAAVELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELQSNKEWLDKIEKDGTLLVSEKPETEAVVKEKLSALHTMWEELESTTQTKAQCLFDANKAELFTQSCADLDKWLAGLEGQIQSDDYGKDLTSVNILLKKQQMLENQVEVRQREVVELQSQVKALGQEVKDTDEVDGRRQVVENKFQELLEPLRRRRNFLVESREVHQFNRDVEDEILWVQERIPVAMSTDHGHNLQTVQLLIKKNQTLQKEILGHQPRIDDILERSQSLLKEESSNGDAIRLADLQQLWKRLMEEVERRHGRLEEAHKAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVTMLKKHQIMEQAVEDYAEAVHQLSKTSRGLVANGHPESERISMRQSQVDKLYAGLKDLSEERRGKLDERLRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDAVNRLADELINAGHSDAATVAEWKDGLNEAWADLLELIDTRTQILAASFELHKFYHDAKEILARILDKQKKLPEEVGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAGRLQSAYAGDKADDIQRRESEVLEVWRSLLEACDGRRLRLLDTGDKFRFFSMVRDLMLWMDDVIRLIEAQENPRDVSSVELLMNNHQGIKAEIDARNDSFTACIELGKALLARKHYASEEIKERLLQLTDKRKEMIDKWEDRWEWLRLILEVHQFSRDAGVAEAWLLGQEPYLSSRELGQSVDEVEKLIKRHEAFEKSAATWEERFSALERLTTLELLDVRRQQEEEERRRKPPSPEPVEVQQEEAQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEJ8</accession>
    <name>A0A3P9CEJ8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Microtubule associated protein 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEJ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020572"/>
    <dbReference type="Ensembl" id="ENSMZET00005021246.1">
        <property type="protein sequence ID" value="ENSMZEP00005020572.1"/>
        <property type="gene ID" value="ENSMZEG00005015434.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182941"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008604">
        <property type="entry name" value="MAP7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF4">
        <property type="entry name" value="ENSCONSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05672">
        <property type="entry name" value="MAP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="674"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="782" mass="88848" checksum="02F96C3B2A5021BF" modified="2019-02-13" version="1">MADQDGSDTSPPESQASYSHFKSEDGTVSSTTRPSSAGSGQTYTPSLTPTPTPTPSRTTNSNSPSNNAGTKTDSLLFNKIDERLRLARERREEREKQNAAKEAQWQAREERARQHYEKHVEERKKKLEEQRVKEEKRRAAVEEKRRQKIEEDRARHEAVIRRTMEKSQKTRQKANRWSWGGTLQTNTPCTTAGFVESAFLYPLDLAGLEHMQSAFSLYYRYGMTSQYADRRSVSTMNLSKHTDPVITKRLSCSSATLLHSPDRGLQMRTVSSPVINKAQSKPHLHQGKTSQQKNTGLRRLPLTPWESNMVNRLQQPTHSYLARSRSAVSLSGDQSVSCHPMGSMSFKALQAQPLPHCRSQERNFSRDAASSSLNTPRRRTTGTTQRQKDRDSVRKSWSNLTLPLAPVLSLPPSKRSSSPIKKSGKVTAPSPGRPPQKPVGRPPTPKLLKSPGAEDPGNLRPVRITPESSHPSTPRGEEDDEQVLSPPQPRPQPLGQNKSSNEQTATSESVSSPPAHKPSAGTTDPEEASRILAEKRRLAREQREREEEERRRQEEQARLAKEELARRKAEERARREEEAQRQAEERRKKEEEEERKAEEERLRKEREEAERLQKQKEEEEARQREEAERLRQERERHFQKEEAERLERKKRLEEIMKRTRRSETTEKKVRNGDNAVNPTSPAASAATETPRHNSNGNLSQPDPTPNPNTTALSHPDQRENGEFEEVLVLPSHSRLSPPEGEEEQQQQQEDNRVPVLAFSENGLLKPLSRVDDISAQQGADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFN1</accession>
    <name>A0A3P9CFN1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Olfactomedin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CFN1"/>
    <dbReference type="Ensembl" id="ENSMZET00005021518.1">
        <property type="protein sequence ID" value="ENSMZEP00005020834.1"/>
        <property type="gene ID" value="ENSMZEG00005015630.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165829"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF31">
        <property type="entry name" value="OLFACTOMEDIN-4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018174077" description="Olfactomedin-like domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="5">
        <location>
            <begin position="114"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="390" mass="44519" checksum="31A103DB05A6B0E7" modified="2019-02-13" version="1">MLQLLLLLLLSSTSQQVSGYKKANACVCQLNSTMWLFPAQKFKYVLEEVHTCEESLNNLQEEVRTHPYAEKLHKHVNKMQTIDTVNMKTVKEKLRYLKNKLETCKSIPKDFRGMCVCLITNISDPITAKVSPFGKSCVSGSWGKQAQKESDGQKNSYWVQPLLSSHIWGNTVRLYQTYEDLMASTNHRDFTFASSYSHPNAIEGPSAVLYGKALYYNCYRSADVCRYDLETNEVKRVTLPGTGVGFNNKFPYCYYDCQLNSDIDVEADETGLWALYATIGNHGNLVISRLVWDSEVKSLNVTQTWETRLFKKATSNAFMVCGVMYATRYVNEYREEVFYAFDTATGKEDNSLAIPLEKVAKAVASLSYNPTNKQIYMYNDGYLLAYQVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGW8</accession>
    <name>A0A3P9CGW8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGW8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021538"/>
    <dbReference type="Ensembl" id="ENSMZET00005022248.1">
        <property type="protein sequence ID" value="ENSMZEP00005021538.1"/>
        <property type="gene ID" value="ENSMZEG00005016172.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230360"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000004">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="144" mass="15469" checksum="D2E3F589D434D0E9" modified="2019-02-13" version="1">MSGRGGKSGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTEKAKKKRALGGKEVALKRAVVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CIT1</accession>
    <name>A0A3P9CIT1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004568580.1">
        <property type="nucleotide sequence ID" value="XM_004568523.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CIT1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021756"/>
    <dbReference type="Ensembl" id="ENSMZET00005022469.1">
        <property type="protein sequence ID" value="ENSMZEP00005021756.1"/>
        <property type="gene ID" value="ENSMZEG00005016306.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480459"/>
    <dbReference type="KEGG" id="mze:101480459"/>
    <dbReference type="CTD" id="7325"/>
    <dbReference type="GeneTree" id="ENSGT00940000165358"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="55"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="201" mass="22246" checksum="72E6F454F01F353E" modified="2019-02-13" version="1">MSSEVQRPDDSPSTSGGSSDIEQRESVPAEQEREQAQPKKKETKISSKTAAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDIAFTPDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRTEHDRIAKQWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CK07</accession>
    <name>A0A3P9CK07_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lin-9 DREAM MuvB core complex component</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004541849.1">
        <property type="nucleotide sequence ID" value="XM_004541792.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CK07"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022635"/>
    <dbReference type="Ensembl" id="ENSMZET00005023385.1">
        <property type="protein sequence ID" value="ENSMZEP00005022635.1"/>
        <property type="gene ID" value="ENSMZEG00005016945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473172"/>
    <dbReference type="KEGG" id="mze:101473172"/>
    <dbReference type="CTD" id="286826"/>
    <dbReference type="GeneTree" id="ENSGT00390000003188"/>
    <dbReference type="OrthoDB" id="2339771at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033471">
        <property type="entry name" value="DIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010561">
        <property type="entry name" value="LIN-9/ALY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045831">
        <property type="entry name" value="LIN9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689">
        <property type="entry name" value="LIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689:SF2">
        <property type="entry name" value="PROTEIN LIN-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06584">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19438">
        <property type="entry name" value="LIN9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01135">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DIRP" evidence="5">
        <location>
            <begin position="128"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="548" mass="62175" checksum="1506AEF17BF87A31" modified="2019-02-13" version="1">MAEMDQLLDESSSAEALVSLKEGSLSNTLNEKNSFPRAHNTRGRHSSVTMDTPTRSSKRSRLFRDEDEPPQQRLPSRSPRRSQRVTTTPQKFSNIVTPDKKASQKIGLRLRNLLKLPKAHKWCIYEWFYSNIDRPLFEGDNEFCLCLKETFPNLKTRKLTRVEWGTIRRLMGKPRRCSSAFFAEERTALRQKRQKMRLLQQRKLTDVSNCKDLPDEIPLPLIIGTKVTARLRGLHDGLFTGQIDAVDTSAATYRVTFDRTGLGTHTVPDYEVLSNEPNETMPISAFAQKHRSARYMQSLMTPPRGPYPSATTPVHMDNDPLITQSPWRNKLPGAEGDTLGGFPVNFLVQVTRLSKILMIKKEHIKHLKEMNTEAEKLKSYSMPIDLDFQKRYATTVLELEQLNKDLNKVLHEVQQYCCELAPDQGMVPADHPTELRRRSEEEAQQMVQMRINAMKDGQQSVANPSLTHLISRLTALLLQIKCLADGGDLNSFEFKSLTDSLNDIKASIDPSNLSCFQNNVEIHVAHIQSGLSQLGNLHAFAANNTNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CK64</accession>
    <name>A0A3P9CK64_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead box F2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004571818.1">
        <property type="nucleotide sequence ID" value="XM_004571761.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CK64"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022708"/>
    <dbReference type="Ensembl" id="ENSMZET00005023458.1">
        <property type="protein sequence ID" value="ENSMZEP00005022708.1"/>
        <property type="gene ID" value="ENSMZEG00005017002.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471063"/>
    <dbReference type="KEGG" id="mze:101471063"/>
    <dbReference type="CTD" id="100002904"/>
    <dbReference type="GeneTree" id="ENSGT00940000163866"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904238">
        <property type="term" value="P:pericyte cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001894">
        <property type="term" value="P:tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097084">
        <property type="term" value="P:vascular associated smooth muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20049">
        <property type="entry name" value="FH_FOXF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Forkhead box F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051770">
        <property type="entry name" value="Forkhead_box_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46262">
        <property type="entry name" value="FORKHEAD BOX PROTEIN BINIOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46262:SF3">
        <property type="entry name" value="FORKHEAD BOX PROTEIN F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="57"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="382" mass="41581" checksum="56992B473DA46F4B" modified="2019-02-13" version="1">MTTETPQQQLEPPPPLRSSPASGVLHPAMLSPQAATESSSNGVKGKKTSSGLRRPEKPPYSYIALIVMAIQSSPTKRLTLSEIYQFLQARFPFFRGSYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPGSEFMFEEGSFRRRPRGFRRKCQALKPMYRMMNGIGFGTSILPQSFDFQGPSATLACHSNSYNLDMMSNSMAGGYDGLSGGHHVPHMSPSPGSTYMASCPVPPNGEYGQDSSSSPVPSSPAMASALDGHSPYASTSAHWASSGGSPYIKQQPLASSSPASSGLHSGMSPYSLEQSYLHQNGRDSHSTDISVGIPRYQSHSSVCDRKDFVLNFNGISSFHPSAGGSYYHHHHHHHPQSVCQDIKPCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CM62</accession>
    <name>A0A3P9CM62_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Si:dkey-152b24.6</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004573541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CM62"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023415"/>
    <dbReference type="Ensembl" id="ENSMZET00005024182.1">
        <property type="protein sequence ID" value="ENSMZEP00005023415.1"/>
        <property type="gene ID" value="ENSMZEG00005017527.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464692"/>
    <dbReference type="KEGG" id="mze:101464692"/>
    <dbReference type="GeneTree" id="ENSGT00390000010118"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF147">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="65"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="316" mass="35588" checksum="93CDBDEE2C682CC9" modified="2019-02-13" version="1">MLAVKFPWLQVGSHFFKMSAGDKRLLFHCVLLSAMVSCHGNNPFFNDNKNLILPASYNIPWMAGIEDFRPLSLITIPGSHSSMARHGGPESEYQVLSLSDQLRAGIRFLDLKVLELEGTLYVMHGVIYERSTFRDVLDTVKAFLSEFNSEAVLIRVVPAILNKNKVNEMVQNLISNDQHVWVTSGMPNIGQVRGKLVFLQKSTFTLGIPLTETDENSSNKVSRVKEEDNKLIKQLAQATEACGGDNVVLTYTSGTGFGTFLGMFLTPKRVAEKVNPWLNQYLRQFYPNHPRPCFGIIAMDFPGFDLIQTVINLNWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMS6</accession>
    <name>A0A3P9CMS6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012774536.1">
        <property type="nucleotide sequence ID" value="XM_012919082.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774537.1">
        <property type="nucleotide sequence ID" value="XM_012919083.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMS6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023339"/>
    <dbReference type="Ensembl" id="ENSMZET00005024104.1">
        <property type="protein sequence ID" value="ENSMZEP00005023339.1"/>
        <property type="gene ID" value="ENSMZEG00005017477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469374"/>
    <dbReference type="KEGG" id="mze:101469374"/>
    <dbReference type="GeneTree" id="ENSGT00440000033697"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03021">
        <property type="entry name" value="DsbA_GSTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044088">
        <property type="entry name" value="GSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="227" mass="25454" checksum="3396E5A729B398C4" modified="2019-02-13" version="1">MTSRKVVELFYDVVSPYSWLGFEVMCRYRNVWNIDLKLRPAFLGGIMHGAGNKPPGLVPNKFAYMTKDLNRLAEYFSVPLQSPADPFEVMFQKGSLAAMRFVAAVQEKEKDGEKVVNVSRELWRRIWSEDKDITEPASLSEAAVKAGLSESEIKELLAMSTSTQVKEKLKSTTQAALDYGAFGFPMIVCHVDGKPEMFFGSDRFELMAHCIGEKWLGPQPSKSAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CN31</accession>
    <name>A0A3P9CN31_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar complex associated 4 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CN31"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023735"/>
    <dbReference type="Ensembl" id="ENSMZET00005024515.1">
        <property type="protein sequence ID" value="ENSMZEP00005023735.1"/>
        <property type="gene ID" value="ENSMZEG00005017749.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016776"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="318"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="530" mass="60428" checksum="20AF6E64A1A45E1C" modified="2019-02-13" version="1">MAPAKKRNVSSVKTAEKSAKKAKVDLSKTVERILESRKHANDVFDILESLQAEQEKEVISAVAACSELFCALLERKELFLGKLPGEEDALSGGYSAEDKYRIFMRHRYTSCVEILLEHLSHEQYDIKESAMCCLMKFAAGEGLHPLEDLDWSEHYSFPRELIQALVDNLLSKATDNSLLISRFQEFLEMEDVRYYVMSSIRDNVGKVMDKSKGAVVPVYQNNVFTLMSSISMPNQESELTNFMVKQEGFLNAIRSSATQEHKRVFERMWLGFLKYKLPNSMYKKVLVILHDSILPYMSKPTLMIDFLTAAYEIGGAISLLALNGLFVLIHQHNLDYPDFYKKLYNLLEPSVFHVKYRARFFHLANVFLSSSHLPVYLVAAFAKRLARLALTAPPTALLIVLPFIYNLIRRHPSCRVLIHKPSAEDEPFEDPYLTDEEDPAQCRALESSLWEIKSLQKHYHPDVAKAALLINTPLSEQEDDISETLEVTTYELMEKDLKQPEIKSVPLEFETATRLLKGGGDVLGQHFCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNC3</accession>
    <name>A0A3P9CNC3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with SLC19A2. Interacts with NTRK1/TRKA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CNC3"/>
    <dbReference type="Ensembl" id="ENSMZET00005024366.1">
        <property type="protein sequence ID" value="ENSMZEP00005023592.1"/>
        <property type="gene ID" value="ENSMZEG00005017399.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158851"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF216">
        <property type="entry name" value="TETRASPANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="161"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="281" mass="30563" checksum="A72A56C61A01C3E9" modified="2019-02-13" version="1">MSTQAPSCCSGAYKVQVIKLYSIWILFLLQMGGLTLLALGIWVSSDGASLLQILRPFSKQSTQVVNVGFFCIVIGAALVLLGILGCYAAHKKSKCLLLTFASIMLIIFISEVATGVVALTYTSFVNKTVPLRKDHYVDNPLHIFSCGMNNTRMSSFFQLHCCGFSNYTDFMGSNFQNATGGSLPSICCRTNNNTCTPAQAEYSNVQGCFQQILMIIKENASTMGGTAAGIGLLEVKTHAKLKDAFKTCLCHSVWTLTLLFLQIAAILVSINLYCHLDNEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSQ3</accession>
    <name>A0A3P9CSQ3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564089.1">
        <property type="nucleotide sequence ID" value="XM_004564032.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSQ3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024836"/>
    <dbReference type="Ensembl" id="ENSMZET00005025645.1">
        <property type="protein sequence ID" value="ENSMZEP00005024836.1"/>
        <property type="gene ID" value="ENSMZEG00005018548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477410"/>
    <dbReference type="KEGG" id="mze:101477410"/>
    <dbReference type="CTD" id="94235"/>
    <dbReference type="GeneTree" id="ENSGT01100000263497"/>
    <dbReference type="OrthoDB" id="6264244at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="10">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="70" mass="7910" checksum="CD8993E14417FBF2" modified="2019-02-13" version="1">MSNNMAKIADARKTVEQLKLEVNIERMMVSKAAAELMAYCEAHAKEDPLVTPVPSSENPFREKKLFCEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CT51</accession>
    <name>A0A3P9CT51_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-binding domain-containing protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CTU1</name>
        <name evidence="6" type="synonym">ATPBD3</name>
        <name evidence="6" type="synonym">NCS6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004558593.1">
        <property type="nucleotide sequence ID" value="XM_004558536.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CT51"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025244"/>
    <dbReference type="Ensembl" id="ENSMZET00005026066.1">
        <property type="protein sequence ID" value="ENSMZEP00005025244.1"/>
        <property type="gene ID" value="ENSMZEG00005018846.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475461"/>
    <dbReference type="KEGG" id="mze:101475461"/>
    <dbReference type="CTD" id="90353"/>
    <dbReference type="GeneTree" id="ENSGT00390000001041"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="53"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="343" mass="38774" checksum="1A577B6DC98D1F2C" modified="2019-02-13" version="1">MPVQCSSCSEKRAVLKRPKTGHSLCKECFFWAFEEEIHQTIVSAKLFKTGESVGIAASGGKDSTVLAHVMKVLNERYSYGLELMLLSVDEGITGYRDDSLETVKRNQQQYELPLKIVSYEELYGWTMDAIVKQVGLKNNCTFCGVFRRQALDRGAIMLKVDKICTGHNADDVAETVLMNVLRGDIARLRRCTTISTDSENEGVVPRCKPLKYAYEKEIVLYAYFKKLDYFSTECIYSPNAYRGYARTYLKDLESVRPSSIMDVIHSGENLSVREGVKMPVQGTCSRCGYISSQKLCKACVLLEGLNRGLPKLGIGKHHRFHDKILSQQPLTEEEERKLKAVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVQ8</accession>
    <name>A0A3P9CVQ8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Transient receptor potential cation channel, subfamily C, member 5a</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
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                <person name="Fan S."/>
                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
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                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
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                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
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                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
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                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
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                <person name="Nishihara H."/>
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                <person name="Ron M."/>
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                <person name="Sharpe T."/>
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                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
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                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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            <taxon>Actinopterygii</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Produces nitric oxide (NO) which is a messenger molecule with diverse functions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:19897"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:19898"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin</name>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="22">Binds 1 FAD.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="22">Binds 1 FMN.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 22">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <location evidence="3">Sarcolemma</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendritic spine</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 22">Belongs to the NOS family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="22"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026437"/>
    <dbReference type="Ensembl" id="ENSMZET00005027292.1">
        <property type="protein sequence ID" value="ENSMZEP00005026437.1"/>
        <property type="gene ID" value="ENSMZEG00005014649.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159357"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048668">
        <property type="term" value="P:collateral sprouting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060218">
        <property type="term" value="P:hematopoietic stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043271">
        <property type="term" value="P:negative regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007263">
        <property type="term" value="P:nitric oxide mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903522">
        <property type="term" value="P:regulation of blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010959">
        <property type="term" value="P:regulation of metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007210">
        <property type="term" value="P:serotonin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021517">
        <property type="term" value="P:ventral spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06202">
        <property type="entry name" value="Nitric_oxide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00795">
        <property type="entry name" value="NOS_oxygenase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06708">
        <property type="entry name" value="PDZ_nNOS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.440.10:FF:000001">
        <property type="entry name" value="Endothelial nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000002">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000069">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1230.10:FF:000001">
        <property type="entry name" value="Nitric oxide synthase, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012144">
        <property type="entry name" value="NOS_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF2">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000333">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12 22" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 22" id="KW-0288">FMN</keyword>
    <keyword evidence="8 22 23" id="KW-0349">Heme</keyword>
    <keyword evidence="17 22 23" id="KW-0408">Iron</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 22 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 22" id="KW-0521">NADP</keyword>
    <keyword evidence="16 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0770">Synapse</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="26">
        <location>
            <begin position="728"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="27">
        <location>
            <begin position="964"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="23">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000333-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1432" mass="161664" checksum="6441995E23E57513" modified="2019-02-13" version="1">MQESEPTVCQLQPNIISVRLFKRKVGGLGFLVKQRVSKPPVIVSDLIRGGAAEECGLVQVGDIVLAVNNKPLVDLSYERALETLKNVMPESHAVLILRGPEGFTTHLETTLSGDGRQRTVRVTRPVLPSSKSYEQWSPLNALSPGQQQQVNKDNQLRAIENLSSPSITQSLLQRGGMQGQDPLLMRDGGRGALLCNGLEENNELLKEIEPVLRLIKNSKKEINGEGQRNAGRRDAEIQVAWDLGVGNGTSPQLVPDNDRMLENMPVVLNNADTDKPPAEGRTSPSKSLQNGSPSKCPRFIKIKNWETGTIYSDTLHHSSSKFSVQPKEDMYLIFYFMIPCPVNRYGSKAHVDRLEEVTKEIEASGTYQLKDTELIYGAKHAWRNAARCVGRIQWSKLQVFDARDCTTAHGMYNYICNHIKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGRILGDPANVEFTEICMQLGWKAPKGRFDVLPLLLQANGNDPELFEIPEDLILEVPITHPKYEWFKDLGLKWYGLPAVSNMLLEIGGLEFTGCPFSGWYMGTEIGVRDFCDSSRYNILEEVANKMALDTRKTSSLWKDQALVEINIAVLHSYQTCKVTIVDHHSATESFMKHMENEFRVRGGCPGDWVWIVPPMSGSITPVFHQEMLNYRLSPSFEYQPDPWNTHVWKGVNGTPTKKRAIGFKKLAKAVKFSAKLMGQAMAKRVKATMLFATETGKSQDYAKTLCEIFKHAFDAKVMSMDEYDVVDLEHETLVLVVTSTFGNGDPPENGEKFGAALMEMCHPTTNTEDRKSYKVRFNSVSSYSDTRKSSSDEPETKINFESTGPLANVRFSVFGLGSRAYPHFCAFAHAVDTLFEELGGERILRMGEGDELCGQEESFRTWAKKVFKAACDVFCVGDDVNIEKANDSLISNDRSWKKSKFRLTYTAEAPALTEALYSIHKKTKVYGAKMLESQNLQSPKSNRSTIFVRLHTNNHDSLRYKPGDHLGIFPGNHEDLVTALIEKLEDAPPVNQIVKVEFLEERNTALGVISNWTNETRIPPCTIYQAFQYFMDITTPPSPVLLQQFAALATNDKQRKKLEILSKVNSLIGHQKNPLDKLTEPYRYLCTTLSFSVTLQGLQEYEEWKWYNNPTLVEVLEEFPSIQMPSTLLLTQLPLLQPRYYSISSSPDLHPGEIHLTVAVVSYRARDGEGPIHHGVCSSWLNRIEKGEMVPCFVRGAPSFQLPKNNQAPCILVGPGTGIAPFRSFWQQRLYDLEQNGMKSCPMILVFGCRQSEMDHIYKEETIQAKNKGVFKELYTAYSREPGKPKKYVQDVLREHLSETVYQCLRQEGGHIYVCGDVTMAGDVLKTVQQIIKQQGNMSLEDAGFFISKLRDENRYHEDIFGVTLRTYEVTNRIRSESIAYIEESKKDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CX02</accession>
    <name>A0A3P9CX02_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551870.1">
        <property type="nucleotide sequence ID" value="XM_004551813.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CX02"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026341"/>
    <dbReference type="Ensembl" id="ENSMZET00005027190.1">
        <property type="protein sequence ID" value="ENSMZEP00005026341.1"/>
        <property type="gene ID" value="ENSMZEG00005019649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478310"/>
    <dbReference type="KEGG" id="mze:101478310"/>
    <dbReference type="GeneTree" id="ENSGT00940000155003"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009607">
        <property type="entry name" value="Enhancer_polycomb_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06752">
        <property type="entry name" value="E_Pc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Enhancer of polycomb C-terminal" evidence="9">
        <location>
            <begin position="594"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="469"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="845" mass="93647" checksum="084E5F287AC134C4" modified="2019-02-13" version="1">MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVYGEKRDNMVIPVPEAECNITHYESLYPGEFKMPKQLIHIQPFSLDTEQPDYDLDSEDETFVNKLKKKMEITALQFEEMIDRLEKGSGQQLVSLQEAKLLLKEDDELIKEVFDYWSRKRKTSKGGCLIPSVKQEKRDGSSTCDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIVEKRNVLPDFGSEVMAEALAQRALVKPVYTIPIIPLSSSNQYRHQDHLDMKDYKKPEKTEAVRTKRKYEKKPKILPMSAPQHSGPPVFNPKDLNQYDFPSSDEEPFSQIHSGSSEAEEENDPDGCYAFRRKAGCQYYAYRPDESGSWPWVSPSDGGLGDPRFRYCLTSLNIPRRCIGLSRRRVARGGRILLDRAHTDVDNICQSLDSDPEPEPLASPLPSSPLHISNASTSETNTSDPASSFHLPPSSSPLSSLKPKDLSQILLNIKSCRWRHFRPRTLSHHPLGGDLSRRGFRDFSWTVSGLNRTLSGGASAQNRIGPATTPVNVFTAEQYQQHQEQLALMQKQQLEQSEQQQQQANIVPTTTNTQALISKTLDQASAQFAASALVTTDQLLACKSKEDPVPVVTSGVNGILPGAGVFKGLHLSSTTAAHHQTNQTTHTTTTAAPTFLQPSSNSATPSPANAVPTSLNSNPGAHAAAALGLLGCSAASATPATTQVLLGNNICLGVSSAASLAARHIPRTLGNVPSSALKLSTTTNLQIPKVSGATSMDMSSRENHDEEKPALNNIADNTVAMEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CX53</accession>
    <name>A0A3P9CX53_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">P-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CX53"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026391"/>
    <dbReference type="Ensembl" id="ENSMZET00005027244.1">
        <property type="protein sequence ID" value="ENSMZEP00005026391.1"/>
        <property type="gene ID" value="ENSMZEG00005019694.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164162"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017957">
        <property type="entry name" value="P_trefoil_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00025">
        <property type="entry name" value="P_TREFOIL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="443" mass="51159" checksum="A465EA6343374AF8" modified="2019-02-13" version="1">LKYYITSFFACLIMIIFPNIFKFFLLLPGTTKAFVPTCPNIPLGERVDCFPDPGASQENCEARGCCWSPRDESNVPWCFFPTNHGYTVESQDSSILKANLIRMDSPSLFGGEIKQLSLEAEMQTNNRLRFKIYDPNSNRFEVPHEHISSLPSNPSIPISSTLQVTQKPFGLTVRRKENQKVVFDTTIAPLVFEDQYIQLSARLPSHNIYGLGEHVHRQYRHDTNWKTWPIFTRDAFPNGVRTPAPAVTYRTIGGLLDFYIVFGDTPEQVVQEFLELTGRPVMPPYWSLGFQLSRWNYTNLDIVKETVERNRAVGLPYDVQYTDIDYMENKKDFTYDKLNYTELPRFADYLHERGQKYILILDPAIATSKRVGDAPYESYDRGTAKNAWVTESDGKTPLIGEVWPGETVFPDYTNPNCIDWWVDEYERFSKEVKHDALWIVSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CXE4</accession>
    <name>A0A3P9CXE4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014265318.1">
        <property type="nucleotide sequence ID" value="XM_014409832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CXE4"/>
    <dbReference type="Ensembl" id="ENSMZET00005027617.1">
        <property type="protein sequence ID" value="ENSMZEP00005026759.1"/>
        <property type="gene ID" value="ENSMZEG00005019923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106675409"/>
    <dbReference type="KEGG" id="mze:106675409"/>
    <dbReference type="GeneTree" id="ENSGT01030000234640"/>
    <dbReference type="OrthoDB" id="8389927at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000024">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052921">
        <property type="entry name" value="GPCR1_Superfamily_Member"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF847">
        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="39"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="307" mass="35409" checksum="636A0D79FA78DB54" modified="2019-02-13" version="1">MDEELNVTYITFDGHVEVNKYRYVYFFIMFTLYILITCSNSIIIYLILIHKNLHKPMYTFIAALLLNVVIYATTIYPKLLIDFLSEKQIISYSACLFQFFIIYSLGCSEFFLLAAMAYDRYVAICKPLQYPTIMRKSTVSIFLVIAWLVPASNIAVQAIGMAKSKLCSFHLKSIFCNNTIYTLQCVKSGLVTVFGIVSYLDLVVFPILFIVFTYTKIFIVTYRSCKEIKKKAAETCLPHMLVLITFSCLGIYDVIMARMETDFPKTARLIMTLQLALYHPLFNPFIHGLKMKEISKHLKILFCPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZF0</accession>
    <name>A0A3P9CZF0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZF0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027713"/>
    <dbReference type="Ensembl" id="ENSMZET00005028592.1">
        <property type="protein sequence ID" value="ENSMZEP00005027713.1"/>
        <property type="gene ID" value="ENSMZEG00005020660.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111268"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="100"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="273" mass="31034" checksum="38E4F633A1779540" modified="2019-02-13" version="1">MLKLRLLNAVAPAYFFTATAVTFIFHFGFFIPTIFPSQGISLDGSKVLHTVIFLFLMFNALGNYIMTIKYPAESANETVIPVCSPHCSDKVDAHYLLNGRHFCKLCKKVILKRDHHCFFTGNCIGNKNMRYFIMFCIYTSCTCLYSLVLGVAFLTVEYSISFENPLTFLTLLPFSTGYFFMGTISGLQLFLVLMLYVWLGIGLVCAGFCCQQVLLVARGQTWCQMQRGQLAENCNPWRANLKDVFGTRWMLGLILPVQTVETCSEDHRHNIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D079</accession>
    <name>A0A3P9D079_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Basal body orientation factor 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D079"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027764"/>
    <dbReference type="Ensembl" id="ENSMZET00005028645.1">
        <property type="protein sequence ID" value="ENSMZEP00005027764.1"/>
        <property type="gene ID" value="ENSMZEG00005020695.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154427"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF5">
        <property type="entry name" value="BASAL BODY-ORIENTATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="401" mass="46233" checksum="D283AA2D9CCC7503" modified="2019-02-13" version="1">MPTNKASNPKKTKGGKEKKEGKRDSKTDKESDVEKAKANAVLWELRLKATEQSLRDYTESCQKVARANEHLTNQLYHAEKDAIHIADWCVFITVDSFFSVSLLCCKLFRRLKDALHSVIKERDCLIDKLKYHIKEAEDLQKLAKLLTEENTSLALDKSMLELTVKDNAAQMGTQKQKLTELRAEVASLEEALQLKAVEIEQQEKKEKANLVTIQASQVELDKLQKVLAMREKEMKHVKQLASTIVAKRQELEEFFHEALGHVRKEIKDSRLQYRQEALQSYRRRFREATAGKIKFPPIRTFHKTAHSTNSVYSDMEAAATWTDQPGSEVEISDLTWEQKEQVLRLLFQKSCGIFSFPLCGDGFDLCVELDALKSKNKSVYITLRQLLCFYSHRPNDRIHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2Q3</accession>
    <name>A0A3P9D2Q3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the chaperonin-containing T-complex (TRiC), a hexadecamer composed of two identical back-to-back stacked rings enclosing a protein folding chamber. Each ring is made up of eight different subunits: TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A/CCT6, CCT7, CCT8. Interacts with PACRG. Interacts with DNAAF4. Interacts with DLEC1. Interacts with SPMAP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546643.1">
        <property type="nucleotide sequence ID" value="XM_004546586.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D2Q3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028634"/>
    <dbReference type="Ensembl" id="ENSMZET00005029539.1">
        <property type="protein sequence ID" value="ENSMZEP00005028634.1"/>
        <property type="gene ID" value="ENSMZEG00005021350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481424"/>
    <dbReference type="KEGG" id="mze:101481424"/>
    <dbReference type="CTD" id="22948"/>
    <dbReference type="GeneTree" id="ENSGT00550000074988"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030240">
        <property type="term" value="P:skeletal muscle thin filament assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="541" mass="59637" checksum="2017124981D17A5D" modified="2019-02-13" version="1">MSTLGTLAFDEYGRPFIIIKDQDKKTRLTGIDALKSHIMAAKAVASTLKTSLGPNGLDKMMVDRDGEVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEQAEQLLDRGIHPIRISDGYDQAARIATEQLDKIAETFPYDPNNTEPLVQTAMTTLGSKVINRCHRQMAEIAVNAILTVADMERKDVDFELIKMEGKVGGKLEDTQLIKGVIVDKEFSHPQMPKVLKDVKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQVKSNGANLAICQWGFDDEANHLLLQNDLPAVRWVGGPEIELIAIATGGRIVPRFCELTPEKLGTAGLVKEISFGTTKDHMLVIMECKNTRAVTIFIRGGNKMIIEEAKRALHDALCVIRNLVKDNRVVYGGGASEIACALAVNQAADKCPSLEQYAMRAFADALEVIPMALAENSGLNPIQTMTEVRAKQVRENNPFLGIDCLHKNTNDMKQQHVIETLIGKKQQILLATQVVKMILKIDDIRSPGETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4U6</accession>
    <name>A0A3P9D4U6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LIM domain 7a</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4U6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029116"/>
    <dbReference type="Ensembl" id="ENSMZET00005030034.1">
        <property type="protein sequence ID" value="ENSMZEP00005029116.1"/>
        <property type="gene ID" value="ENSMZEG00005021683.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183159"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000041">
        <property type="entry name" value="LIM and calponin homology domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031865">
        <property type="entry name" value="DUF4757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029978">
        <property type="entry name" value="LMO-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767:SF1">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15949">
        <property type="entry name" value="DUF4757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="601"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="983"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="859"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="983"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1168" mass="132276" checksum="6D76031153EB30A7" modified="2019-02-13" version="1">MGIKPLPTSSVSYDKFLPKFWTPEEDIHIQKIKLGSQRRPWYKKIQGFSVTVKSTFDQLLFESNVTTVAACCIFSSFFCSLIRFTRMHSPPLCPFLSFCLLCSPHVQPHTPPQHPKSPLLETPPLVFAPVDPTSGPRLVKGEKWMLLGRQDPREPPDPIDYESICPDLENDDMFARRTLAFQSNTNLAKLKTLLTCRHRRCTSEPQLNIVTQKPVRGGAEETEFPDIEQDDVVFRREKTQQAQQQRPLSGAPDNYAPMPIPEPWALPPDLKSRLLCPPCPLTHKAAIPNLNEVDKETRPETDDMLIRKFRISSQKTPSVPSSCSKEDLQKWQAIREASQLRHKKRLLVERLGFFFALQALSDWKSRRRSVNSDIVKKKEEREKIEQITYGGEKRSKTFKEMSNRLTAVVVFLLLISGDSAKKQEAPTVVSSSSSLPKVPEPSPALSGTQTEVKPLSSGPLHTQAQPSSMEPKPPAVSRVSSSLPKTYQRSDSTRLTSVVTPRPFGSQPSRITSLPRGFTTDDSHKRVNGNVDVSKKSSVPSRYHQFMTSEDEAQSSSAHSSEEEEEEATTGNSVNSAQSVTPVPPQVKSEPPAPENYCEMRISLNQKPNSSRDFGFQAAWDSTGACVTSIQPGSPAEMCQLQTGDKVLTVNGHKVADMSYTEWKSHMDEALQEGSLVMDIRRHGQNNWDRVQPSLPFKSHKTINLTSTDHPMLVGSQEKSTISSSLDFTSNTPAETLTFKETPQISTGCLRDYYLSIITSIWHKQADFKATKFSDSFVQLRGKFAMCGFLFCLQIPVPVITPSSRWSFDPEEERKRQEKWQKEQERLLQLGSLEVNNHSNSSTGPHSPLSPVNQPTSLLWEEEERKRKEEQERQRQAEEKRKREEEERELLRLQEQRMRKERQEQEERKRREDERRLLEAEELQRREKERAFEQQQQWSVEPLLILCCPEYSNSHKKDQQPASQAELERQQILNEMKKKTSLLTDNSWIRQRSPDTSTNKERDLPPMRRGDSLDNLDTSYNSWRSSSKPRSGSFAQNYFRPHSALSGSTSFYGGGPRAQRYGSTSTLPSSYSMGSLRSGAGSHLVPWSRQSSVSGKKICTFCETPLGKGAAMIIESLGLCYHLGCFKCIDCKSDLGGSEAGAEVRIRNKQLYCNSCYMRVKTGQPTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4Z3</accession>
    <name>A0A3P9D4Z3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Scm like with four mbt domains 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004570050.2">
        <property type="nucleotide sequence ID" value="XM_004569993.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024661486.1">
        <property type="nucleotide sequence ID" value="XM_024805718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4Z3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029161"/>
    <dbReference type="Ensembl" id="ENSMZET00005030079.1">
        <property type="protein sequence ID" value="ENSMZEP00005029161.1"/>
        <property type="gene ID" value="ENSMZEG00005021734.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158123"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20118">
        <property type="entry name" value="MBT_SFMBT2_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09581">
        <property type="entry name" value="SAM_Scm-like-4MBT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.190">
        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047355">
        <property type="entry name" value="MBT_SFMBT2_rpt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037604">
        <property type="entry name" value="Scm-like-4MBT1/2_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021987">
        <property type="entry name" value="SLED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038348">
        <property type="entry name" value="SLED_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF62">
        <property type="entry name" value="SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12140">
        <property type="entry name" value="SLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="41"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="156"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="271"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="385"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="831"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="676"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="904" mass="102010" checksum="2FA714429754B664" modified="2019-02-13" version="1">MQSHTQEQPLALTTVKPHYPTNGKEEEVNTDADSMEEEVEFNWEEYLEENGADAAPHTNFKHVEISLQSSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRFSGYGEDRKADFWCDVMTAELHPVGWCAQNNKTLMPPEDNIYLRKAIKEKHSDWTEFLIQDLTGARTAPANLLEGPLRGKNTVDLIVDGSVLELQDLLDPYLYWPVRVIQNVGGRLRLRYAGLSEEYHDHDTWLFYLDVRLRPLGWAQENCLTLEPPTELRSTNSTSDWQQALEDAQLDGQKNPLPLEVFKDHVDLPKHSFKMGMKLEMVSPWEQLQICPVSVTKVYNEFYFQVMLDDLSAEAKPHFVVCHANSPGILPVQWCMKNGVGLERPRAYEGQDFDWADYLKQSGTEAAPDACFPDTWQSRDFAKDMWLEAVNPHRPAEVCVAQVTQVRGRLLWLRLEGVPKPLSECIVDVESMDIFPVGWCEANAYPLTPPIKPVCQKQKKIAVVQPEKQLARSQPVEASPVNHYQPAALDPGSANGRYCCSKIFVNHRCFSGPYLNKGRIAELPQAVGPGKCTLVLKELLSMLINAAYKPGRVLKELQELEDQSWDCQEETLKAKYKGKTYRSTIRIVRLADQIPDFCRKVCVKLQCCPNLFSPILVTDKCPENCSVQTKTKYTYYYGKKRKLSKPTAGEETAEGELAKPTRRRKKRKAIFVQKKRRSSAVDYTPAGSPQDSDEGEEDEERALQSGSEGTSSEPREDHTDTSSVEVTSSRPRRATALRRAVSAGNPALGPALSPEAPAGRRRSTRSLSAYNQNSKYQPAKGQDMQVEEEDGQLVLDRNPLEWSVDEVVQFINSTDCASLAGIFQEQDIDGQALLLLTLPTVQECMDLKLGPAIKLCHQIERVKVAFYKQYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6C2</accession>
    <name>A0A3P9D6C2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proline, glutamate and leucine rich protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6C2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029889"/>
    <dbReference type="Ensembl" id="ENSMZET00005030829.1">
        <property type="protein sequence ID" value="ENSMZEP00005029889.1"/>
        <property type="gene ID" value="ENSMZEG00005022289.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167512"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012980">
        <property type="entry name" value="PELP1_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08166">
        <property type="entry name" value="PELP1_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PELP1 middle" evidence="8">
        <location>
            <begin position="314"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PELP1 middle" evidence="8">
        <location>
            <begin position="469"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="975"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="837"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1130"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1186" mass="126663" checksum="816EFD7B8DE8CEA8" modified="2019-02-13" version="1">MLVKDSSSDLFQQHCLSWLRSLQQVIQSQAPVETVQLAVNILKDLLQYSSQLAELAREVGLNSILGILTSLLGLKSECELAAMEGMTACMTYYPRACGSLRDKLAAYFLSKMDSTDRKTQEMACQCYGRLPCLGGVLDRGVGAGRAEGWTNQIHCLLASANGLLAQLYQGSETDGAMQYQGPGMELAFPHLDPTDPLLLLQLQHRYTAVCLALKHTLRVDPASAVRLPVRPMLNLVCRALAVSSKSINLTGDGSVRLLVLPIIHSITLEVLSSVITVVRVGMVQYAAVIQRLFSQTLSAWTPLPETSVGQQRAYSAVRVSVYRTLELWVQVAGASSSILQGSPGHSELLFNHLLGDITPGAESVKLRAGLSADVVPGGKPGPRRTKHLVMADTVGPSLQRKGDHLANQDTCLAAVRALRQIIQTSGTLLKDNIHKRLHEVVLPLCVRLQQQQSCSSNACESAGSASGQYSSALTRRELYRLLLALVLVPSPCWPPPLTCAVSILSNGRTDRNVKVSSFCAEALTICNLILHPRFPSIALPLPPLTMKPSSTTPVLPSSQGPAPGLTLPTLLGGPAPGPPFPARHSVNLGPASLLSSFENHLSLVPGLPGQGPTAGDMILSPHSHHQPDPAGLGPPEGQRPVFVRFDKEEAEDVEISLASDSDDSVVIVPPGMLNMETQQDDAAANSQSMSSSAPGGTGVTLAGAESVTMVPTTAAAATIDGVSLPNALAASSPLLTASTTSINSFPPSSASVVSLVPPLNSSTFTAPPVGLGESLPGRPQLQQMLMQPSTASQAGPMGLPLQMHLQNQLSQQGRHLHQQPAAAASSEDSAVININSTDDEEEDDEDIDEDEELEEDEEEEGIDEEDEEEDVSELADEFFDGEEYEELDEEDGEDLEEEEEEEEEEEDGDIPPLEGVEDKDGGSGIQEGKLDEGRISAFNVEERTEGGIEEIQTNRALFGEDTMKVQEVESIGVLEAAREGEVEEEDNERMDDPTMPQILCVTGGALEEREEAEEEREQAGAELQKEECSWEQGAKEDEPQAAESEQPASQQESAAEPAEDASVSDNQLPSCEDEPLEAVQAGDSTAVADSENATEPNVTEKQEEDTEKSSEKEAEQPETGAGGGQESNGEEGKGVKRKREEGHGKEEVGQSPEKKKMDDEAMASMLADFVACPPDDEDGASGSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7G7</accession>
    <name>A0A3P9D7G7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neuregulin 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553461.2">
        <property type="nucleotide sequence ID" value="XM_004553404.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7G7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030041"/>
    <dbReference type="Ensembl" id="ENSMZET00005030986.1">
        <property type="protein sequence ID" value="ENSMZEP00005030041.1"/>
        <property type="gene ID" value="ENSMZEG00005022403.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474689"/>
    <dbReference type="KEGG" id="mze:101474689"/>
    <dbReference type="CTD" id="145957"/>
    <dbReference type="GeneTree" id="ENSGT00940000175594"/>
    <dbReference type="OrthoDB" id="6162427at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021494">
        <property type="entry name" value="DUF3149"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740:SF15">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11346">
        <property type="entry name" value="DUF3149"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="109" mass="12287" checksum="AE52FFDC7CB3A299" modified="2019-02-13" version="1">MMSDHGNPCSAEDATYCMNGGTCYKISSMDTLSCVCNPNYKGSRCEQFQLGVTQPISDEAGLIAAVIVITLLILIVLGFIVYYIRKMRKAKEQRQQNHNQEYWKVQSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D811</accession>
    <name>A0A3P9D811_9CICH</name>
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        <recommendedName>
            <fullName evidence="10">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
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    <dbReference type="STRING" id="106582.ENSMZEP00005030703"/>
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        <property type="protein sequence ID" value="ENSMZEP00005030703.1"/>
        <property type="gene ID" value="ENSMZEG00005022860.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182838"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1230:FF:000003">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000004">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
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    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6 10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="13">
        <location>
            <begin position="702"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="933" mass="103469" checksum="4AA81EEEF4057FD8" modified="2019-02-13" version="1">MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLSSRNPTFMCLALHCIANVGSREMAEAFASEIPRILVAGDTMDSVKQSAALCLLRLYKTSPDLVLMGEWTSRVVHLLNDQHMGVVTAAISLITCLSQKNPDEFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSCKLLRLLQCYPPPEDGAVKGRLVECLETILNKAQEPPKSKKVQHSNAKNAILFEAISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVAEMLSYLETADYSIREEMVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPLVQFNLLHSKFHLCSVPTRALLLSAYIKFINLFPETKATIQEVLRCDSQIRNSDVELQQRAVEYLKLSSIASTDVLATVLEEMPPFPERESSILAKLKKKKGPGAVSVTELDDSKREAGELNGGADRGPDTASTPSPSADLLGIRSAAPVGAAQTNAGSLLVDVFSDSGPAAPSAAVNDDGFLRFVCKNNGVLFENQLLQIGIKSEYRQNLGRMYLFYGNKTSVQFASFSTTVSCPGELQLNVQSKPVEPLVEGGAQIQQVLNIECITDFCDAPLLNIKFSRYGGALQNLTLKLPVTINKFFQPTEMSSSDFFQRWKQLSQPQQEAQKIFKANHSMDTEVLKAKLLGLGTALLDNVDPNPENYVCAGVIQTKGQQIGCLLRLEPNAQAQMYRLTLRCSKDTVSKRLCELLAQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D816</accession>
    <name>A0A3P9D816_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTP4 small subunit processome component</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004556265.1">
        <property type="nucleotide sequence ID" value="XM_004556208.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D816"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030708"/>
    <dbReference type="Ensembl" id="ENSMZET00005031673.1">
        <property type="protein sequence ID" value="ENSMZEP00005030708.1"/>
        <property type="gene ID" value="ENSMZEG00005022868.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487953"/>
    <dbReference type="KEGG" id="mze:101487953"/>
    <dbReference type="CTD" id="84916"/>
    <dbReference type="GeneTree" id="ENSGT00940000153533"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061007">
        <property type="term" value="P:hepaticobiliary system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000617">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055589">
        <property type="entry name" value="DUF7165"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23749">
        <property type="entry name" value="DUF7165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7165" evidence="1">
        <location>
            <begin position="440"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="684" mass="76943" checksum="F6436AFAEBDFB06A" modified="2019-02-13" version="1">MGEFKVHRVRFFDYMPSAIRTMAFNSQTERLAVARADGAVEIFNFNDNFFQEKVIPGQDGRATEALCWVGHRLFSAGLNGEIIEYDLENLRPQYTVDAYGGPIWTISSNSQGTQLAVGCEDGTVKIFAILEERIQFQRNLNRHKGRIISLCWHPSSAQIAAGMTDMIKIFDAETGHATRRLLVDRAMGASKNKEVVVWSVGYLSDHTIISGDSAGKVQIWNGLTGTLVRTYLVTKWDVLVLSVSKDESSVIAGTSEGTVIQFQFISSTVDQHDKEWVRTRTFRNHSHDVSALAHTDTAVVSGGMDTQLVVRPLLDKVEKNTQESALRKIAFPHRSLVGCAKKAGLLLFQFPDRLELWKLGESEGHGKPGDRLPVKRKPEKLIELKRKGEDHICCSALSACGGWLAYSTVSSVRLYRIQYNNTISINKVSKLPKELRSVHQLCFSSDSSKLFASSCQSSVIVVAVSQQECRYLHTLKHKTGSRQPVHLLCASDDGKWLATANTDCEIHIYNLHKMKLHCMVPVYNSCPTTIAIHPVTNNLISVHADQQIFEFSLVQKEYTQWSRRLQAQGLLSLWLERDTPITHITFNPKNPDHIILHDTYMFCIIDQSLPFPELNAVLWNQMTLKSLPVSQRIGQSHAFKICKSFQHLMCVSLLEDLSLVVVERPLLDIMSQLPAPVRQKKFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8I9</accession>
    <name>A0A3P9D8I9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 646</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8I9"/>
    <dbReference type="Ensembl" id="ENSMZET00005032027.1">
        <property type="protein sequence ID" value="ENSMZEP00005031025.1"/>
        <property type="gene ID" value="ENSMZEG00005023131.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164729"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001345">
        <property type="entry name" value="zinc finger protein 646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF99">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF52.1-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="410" mass="44841" checksum="DD2E1B226689A314" modified="2019-02-13" version="1">MYARTNTSSTHGDFQDRNGVNYVTSTESFGHCSQLFWKKDPNDSGPSSTISWCDQLPSSSAALSTSSLSSASLSSSSLSSASLSSSRLSMESQAPAPAPPPATTVSDDMESDERPYVCDLCSCAYKHASSLLNHKLTHKTGDFRCDFCSKPYTNYMSLRNHMRIHGQKRYMCDLCGKAFRLARYLRNHQRIHDDGPNRFDCPSCCKSYRTMLELAQHRCSAAVSNQSGGRRSNFSATPRRQQQQQQQQQNNANSMMQPHGGHGQPEPLPSHCVSPMSQGGQGGGVASQSVPDPHQGRPSSVSSQASQQNMRSSSSNKHVSSSSATPSSSYSLLQPLVPEVKEMSSGYTRLSANPMPKHQDTFSLPPQRPLTTINPIGHSLHPNGAPTLKPSPVPRTIQAMPWEQRSLYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9F2</accession>
    <name>A0A3P9D9F2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9F2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031198"/>
    <dbReference type="Ensembl" id="ENSMZET00005032205.1">
        <property type="protein sequence ID" value="ENSMZEP00005031198.1"/>
        <property type="gene ID" value="ENSMZEG00005023266.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005976"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF67">
        <property type="entry name" value="PROTEIN SPINSTER HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="488" mass="52871" checksum="B3B213E0E484C69A" modified="2019-02-13" version="1">FLDIPVRRWSLRSSCSLPYGSFANSLASLAPDAEEKPAISPKRAYVTMFVLCYVNLLNYMERYTIAGVLTDIQKFFDIKDSTAGLLQTVFICSFLLLAPLFGYLGDRYNRKYIMIGGLSVWLLTATASSFVNESQFWLLALLRGLVGTGEASYSTVAPTIISDLFTGGKRSIMICIFYIFIPVGSGLGYITGRGFASLTGDWHWALRITPIMGAVGLILMIVLCPNPPRGAAETHGEGVTEQSSYLEDVKYLLKNKSYVWSSLGVTALAFLTGALAFWLPNFLSRARVYQKLSDKPGDSSDSYIFGAVTVATGILGGALGTSLSRRFRDKVPNADPLICAVGMLGSVPCLFITIFVASASIPATYVFIFLGELLLSLNWAVLADILLYVVVPTRRATAEALQITVGHLLGDAGSPYLLGVISDAIYPGSPDRNFDSLKYSLLLCPVVGIVGGVFFVVTAVYIAEDRKAVQQLLGGNKTQKTQTPKTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DA13</accession>
    <name>A0A3P9DA13_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formin-like protein 13</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_012921597.3"/>
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    </dbReference>
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    <dbReference type="KEGG" id="mze:101470239"/>
    <dbReference type="GeneTree" id="ENSGT00940000165811"/>
    <dbReference type="OrthoDB" id="410721at2759"/>
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    </dbReference>
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        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
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    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="177"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="428"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="698"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
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            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
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            <begin position="383"/>
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        </location>
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            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="800" mass="91052" checksum="5B1158245BF7D6BF" modified="2019-02-13" version="1">MPTLGSKRKDNPPRMEKYTGGMPQLSNEMQLDILNKVKSGQLSIDDALQQARMDREQKMTDDKELESQYNFSVYKHGRYRWQKRVLQIDFRTKMVCSIEKGIVKRQLPFSIVKSCDDGEGSRYSISFKGHHDYELEATSLEDKHKMMELVNKIIYNNIYNDHGEENAESQEQSQAPQSIREGMLLLHRGGLASFKWMKYEARLHPGQLTLVPLRDGEMILSVPVSTVIHLSDGDTRVQKCNDSDTFSLITHKNEYQFKVPDETVALGTVQQERDAWVKAIDKLCSEWKRKSKMFMEQKSFRQVSITEDTEDNDTDLESSGEFGAGSITYPPADNKNVDPPLSDGDNLSAQQTHPPADHTKPIPKPRRRNSPQIIPPQVSLLPSPSPTSPTSPPYSLRAILQPPPAVPESPAQEAGPPPRSIPAPPPLPLNLNSKKACTKVFHWDLIGPDKIAKSFWIQERMGRIEIDTSLLHKQFAVKDLRTVGVVEPNNTQHIMLNQKIAHNFNIFLKSFPVQPGELKDKLFIINEKDGGLSDEHITSLRRYVPTMEDVERYKSYKGPVAELHIVDQYMMEMCNIAYLSTQLDLLLTLRELPISMNDLQPLINQKIRMCMQLYYCRSFVSVLEYLLAIGNYLNENAGKEKAKGFRLSSLTKLVQLRGTDKKFTLLHALVEQIMLHEPCLATFPQELAEFETVPGASIKGLTAEVDVLKNELKKITQYRKMSKKKNIAAQNPNFFKDLKMAIEKYNADLSALTKTCEEMKKLYSDILVKFGEPADQDSQELFGLLCQFVHDFKRAHAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DA99</accession>
    <name>A0A3P9DA99_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein NATD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NATD1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004556363.2"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005031284"/>
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        <property type="protein sequence ID" value="ENSMZEP00005031284.1"/>
        <property type="gene ID" value="ENSMZEG00005023321.1"/>
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    <dbReference type="GeneTree" id="ENSGT00390000014840"/>
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        <property type="component" value="LG4"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
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        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PROTEIN NATD1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="129" mass="14509" checksum="469B53D3B4CACCCA" modified="2019-02-13" version="1">MAFRILSRVCTLSHGLKSSQTAFSTLSSAGSLKVEHDRRNQRFTVTAGSSTADHECGVLKYRFTGEKEVDLMSTFVPETYRGHGVAALLSRAALDFVVEENLKAHVSCLYIKKYVEEQPEQRYKEFVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DB57</accession>
    <name>A0A3P9DB57_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DB57"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031930"/>
    <dbReference type="Ensembl" id="ENSMZET00005032964.1">
        <property type="protein sequence ID" value="ENSMZEP00005031930.1"/>
        <property type="gene ID" value="ENSMZEG00005023819.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000181745"/>
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        <property type="component" value="LG6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018244050" description="Reverse transcriptase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17545" checksum="9F7FB20425018553" modified="2019-02-13" version="1">MASNAGICSVLILLDLSSAFDTVDHKILLNRLKFLAGLSGSVMGPLLFSFYILLLAGTIKYFSDLDMSLKPHHTNGIIIAKGSTHQALTPLSTHHQAGFSKNEKTQCFLCNVILSLFRVSFFITFKDILMKVHSMDSMDGWQHRGLHRCARYSCQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DB79</accession>
    <name>A0A3P9DB79_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 34 member 2a</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DB79"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031955"/>
    <dbReference type="Ensembl" id="ENSMZET00005032989.1">
        <property type="protein sequence ID" value="ENSMZEP00005031955.1"/>
        <property type="gene ID" value="ENSMZEG00005023833.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183177"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01013">
        <property type="entry name" value="2a58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF47">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 MEMBER 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018333417" evidence="9">
        <location>
            <begin position="29"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="642" mass="69501" checksum="94C0EB9F3CD2FA6A" modified="2019-02-13" version="1">MCVCSRTKMVFFLMFIEIKASPAHSTAALIVDEPEETDPWDLPELKDAGVPWSALDTKGKVLRVLISVGKLILLLGFLYMFVCSLDILSSAFQLVGGKTAGDIFQDNEILSNPLAGLVIGVLVTLLVQSSSTSSSIVVSMVSSGLLTVQVAVPIIMGTNIGTSVTNTLVAMTQAGERNTFRRAFAGATVHDFFNWLSVLVLLPLEVASGYLFVVTKLITDSFEIQSGEAPDLLNVITDPLTESIIELDASVISGIATNDPEAKNKSLIKRWCQTFTNTTLMNVTVPGPENCTSPSLCWVDGNYTFTLKNISQTYNIKKCTHLFVDVNLSDMAVGLILLALSLLVLCSCLILIVKLLNSMLKGQVAVVIKKVLNTNFPFPFGWVTGYIAILVGAGMTFIVQSSSVFTSAITPLVGIGVISIERAYPLCLGSNIGTTTTAILAAMASPGETLADALQIALVHFLFNISGIILWYPIPFTRVPIRLAKGLGNITGKYRWFAVVYIICCFFVLPLLIFALSLAGWKVLVGVGVPLLIMLIIIIVINILQKQKPGWLPAVLRSWDFLPLWAHSLAPCDKAVGVLIAKCCCCCKCCQAASDDQEDRAEQLENNKTTHTAVYDNHAMSVENEAEDGMKIELNILKMTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DBY9</accession>
    <name>A0A3P9DBY9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leucine rich repeat transmembrane neuronal 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Postsynaptic cell membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the LRRTM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549583.1">
        <property type="nucleotide sequence ID" value="XM_004549526.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DBY9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031661"/>
    <dbReference type="Ensembl" id="ENSMZET00005032693.1">
        <property type="protein sequence ID" value="ENSMZEP00005031661.1"/>
        <property type="gene ID" value="ENSMZEG00005023622.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471361"/>
    <dbReference type="KEGG" id="mze:101471361"/>
    <dbReference type="CTD" id="347730"/>
    <dbReference type="GeneTree" id="ENSGT00940000161705"/>
    <dbReference type="OrthoDB" id="5984255at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000005">
        <property type="entry name" value="leucine-rich repeat transmembrane neuronal protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="517" mass="58829" checksum="FA3D54753BD0ACB2" modified="2019-02-13" version="1">MLMDFLLIGLYLKWPLKKPPGLILCSLGIFLRTVPLVEGVCPRLCRCDSKLLYCEGLNLTDIPRNLSSAMGLSMRENNLTELREGQLAGLSQLTWLYLDHNSIDVVEEGAFDKLRRVKELDLSNNRIESLPNGTFRPLPNLRILDLSYNRLQVLEPDLFHGLRKLTNLHLRYNALKFVPVRIFQDCRSMQFLDLGYNQLQSLARNSFAGLFKLTELHLEHNELVKVNLAHFPRLISLRTLYMHNNRATIVVNTLDWTWHFLEKIDLSANEIEYIEPHVFESTPNLKVLMLDSNRLTSVDQRILDSWSSLDSITLAGNDWECSRNVCALASWLSAFRGQHDNSLLCSSPDTAQGEDVLDAVYAFQLCEDPPVEVTTAGLYASTRDLGPITPNPYEGEGSEVVTNSFTVTVGHDDLESTMQIHKVVTGTMALIFSFLIIVLMLYVAWKCFPAGIRQLRQCFSSQRRKQKQKQSMQQMAAISTPEYYVDYKPNHIEGALVIINEYGSCTCQQQASRECEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DBZ0</accession>
    <name>A0A3P9DBZ0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DBZ0"/>
    <dbReference type="Ensembl" id="ENSMZET00005033256.1">
        <property type="protein sequence ID" value="ENSMZEP00005032215.1"/>
        <property type="gene ID" value="ENSMZEG00005023997.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000178507"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="98" mass="10361" checksum="0DCFDDF1B4DD9745" modified="2019-02-13" version="1">ITREASFRALEAFISPSASSIPLITLALASRLASASAAMARCMASSRASCRVTSNIKHSSHSYSLINNKSNTLYSTVRKPVASTCSSILLVAKKKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCM1</accession>
    <name>A0A3P9DCM1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCM1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032109"/>
    <dbReference type="Ensembl" id="ENSMZET00005033147.1">
        <property type="protein sequence ID" value="ENSMZEP00005032109.1"/>
        <property type="gene ID" value="ENSMZEG00005023932.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153470"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF6">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="15">
        <location>
            <begin position="176"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="754" mass="85488" checksum="382D382DBDB783CF" modified="2019-02-13" version="1">MIAGSTDAKIMVRRCLVTFKPFRIFVMGIGFFSLCFLMTSLGGQFSAKRLGDSPFTIRTEVLGGVESRGVLRKISDMLEVILKRMDSLSKLDNTSTTDARGGGDIFFRFQPASLVERIQAIAQNVSNMAIRVEQILQNSMVQDGSSSQCEVPRDPRFPECPGKVDWMRARWTSDPCYAFYGVDGSDCSFLIYLSEVEWFCPPLAWRNHTQNVSPVLPFIFSHSQAAFRTDLSVLLDQVGTGKESLSFMKRRIRRLAQQWATAANRLDAKLEQQWRDQKKILVHVGFLTEESGDVFSPKVLKGGPLGEMVQWADILTALHVLGHNLKISMSPPTTHGPFEVKYTDILIIFFCHFLCRCHIRVIDTFGTEPAYNHEEYATLHGYRTNWGYWNLNARQYMTMFPHTPDNSFMGFVSEELNETEKRSIQQNKVNNMAVVYGKEASMWKQGKESFLQILHKYMEVHGTVYYETQRPPEVPAFVKNHGLLPQHELQQLLRKAKLFIGFGFPYEGPAPLEAIANGCIFLQPKFNPPHSSLNHEFFRGKPTSREVFSQHPYAEQYIGRPHVMTVDYNNSVEFDSAIKEIMRTKVEPYLPYEYTCEGMLERVHAYIQHQVSVGSAGGSRMMGPLFVPLPNTTALGWASSVTAPSAWPPLSSLRLLVSQEGQSCVDACQSAGFICEPAHFRFINNKEALLDVQCEVVDSEINHILPAFSVVRQECGLQREPLLFSCAGHSPKYRRLCPCRDFRHGQVALCRDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDL2</accession>
    <name>A0A3P9DDL2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myeloid associated differentiation marker</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MAL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555250.1">
        <property type="nucleotide sequence ID" value="XM_004555193.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DDL2"/>
    <dbReference type="Ensembl" id="ENSMZET00005033495.1">
        <property type="protein sequence ID" value="ENSMZEP00005032449.1"/>
        <property type="gene ID" value="ENSMZEG00005024170.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466547"/>
    <dbReference type="KEGG" id="mze:101466547"/>
    <dbReference type="GeneTree" id="ENSGT00950000182933"/>
    <dbReference type="OrthoDB" id="8757663at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047123">
        <property type="entry name" value="MYADM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068:SF3">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="143"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="293" mass="32056" checksum="AFE36AF9BDCB3298" modified="2019-02-13" version="1">MAIVLHSSPLLWTRLAALAFSCVAFSVAVHGAQLVHGTGDWCIFCWAFSFAGTLLVILVELFGLQTKAPVSWKNFPITFACYAALLCLSASIIFPLYFLKGLSGSSSVRDYRIVVTVFSCLATIAYISEVSISKARPGEVAGYMATGPGLLKVCETFVACVIFVFVSDPVLYDRHDALKYCMAVYCICFILSAAIILLCIGECTGCLPFPFPRFLSAYAMLAVVLYLSATIIWPIFNFDPKHGGDKNRPYNCSSQPGLCLWDKRMAVAVLTGVNFILYLADLIYSTRLVFVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DF98</accession>
    <name>A0A3P9DF98_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-activating enzyme subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004569685.1">
        <property type="nucleotide sequence ID" value="XM_004569628.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DF98"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032832"/>
    <dbReference type="Ensembl" id="ENSMZET00005033891.1">
        <property type="protein sequence ID" value="ENSMZEP00005032832.1"/>
        <property type="gene ID" value="ENSMZEG00005024449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464385"/>
    <dbReference type="KEGG" id="mze:101464385"/>
    <dbReference type="CTD" id="10055"/>
    <dbReference type="GeneTree" id="ENSGT00550000075007"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060216">
        <property type="term" value="P:definitive hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061484">
        <property type="term" value="P:hematopoietic stem cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000274">
        <property type="entry name" value="SUMO-activating enzyme subunit 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="11">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="345" mass="38463" checksum="4532CBD513041C72" modified="2019-02-13" version="1">MIEKEDPVISEEEAAQYDRQIRLWGLDAQKRLRGSRVLLAGLGGLGAEVAKNLILAGVKGLTLLDHEQVSEESCRAQFLVPVTAQGQNRAKASLERAQNLNPMVKVHADPDRIEDKPDDFFLQFDAVCLTGCSRDLMIRVDQLCSKHNIKVFCGDVYGYYGYMFCNLGQAHNYVEEKPKVVKPSGESNDGPKAKKAKVDPNETTMVKKTASFCTLKEALAVDWTSEKAKAGLKRTPVDYFLLQVLLKFRTDKGRDPDPQSFPEDSQLLRQIRDDVLESLSLNSDLLNDDFISYCFSEMSPVCAVVGGVLGQEVVKALSQRDAPHRNFFFFDGRKGNGVVDYFGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFK8</accession>
    <name>A0A3P9DFK8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-acetyltaurine hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphotriesterase-related protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-acetyl-L-isoleucine + H2O = L-isoleucine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:133735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:81120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-leucine + H2O = L-leucine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:58270"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:81116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-acetyl-L-methionine + H2O = L-methionine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:71670"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67441"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-L-valine + H2O = L-valine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81123"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:133716"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:81124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyltaurine + H2O = taurine + acetate</text>
            <dbReference type="Rhea" id="RHEA:81107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:133737"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:81108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-propanoyltaurine + H2O = propanoate + taurine</text>
            <dbReference type="Rhea" id="RHEA:81111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:231795"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:81112"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004542936.1">
        <property type="nucleotide sequence ID" value="XM_004542879.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004542937.1">
        <property type="nucleotide sequence ID" value="XM_004542880.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004542938.1">
        <property type="nucleotide sequence ID" value="XM_004542881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFK8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032947"/>
    <dbReference type="Ensembl" id="ENSMZET00005034015.1">
        <property type="protein sequence ID" value="ENSMZEP00005032947.1"/>
        <property type="gene ID" value="ENSMZEG00005024543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484557"/>
    <dbReference type="KEGG" id="mze:101484557"/>
    <dbReference type="CTD" id="9317"/>
    <dbReference type="GeneTree" id="ENSGT00390000006960"/>
    <dbReference type="OrthoDB" id="9998343at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00530">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819:SF3">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="349" mass="38661" checksum="F694E4808725DC15" modified="2019-02-13" version="1">MSELSGRVQTVLGLVDPDQLGRTMTHEHLTMSFECCFSPPPPGDEAVAENPFQMQHMFWLRQNPYSSPENLLLKQETAAVRDELLAYRRAGGGTIVENTTTGIERDLPTLRQLAKDTGVHIIAGAGYYVDCTHSEATKGMSVEKLTDIIISEVLHGADGTDIRCGVIGEIGTSWPITESETKVLRASAHAQAQLGCPVIIHPGRDHAAPAEIVRILQEAGGDISKTVMSHLDRTILDEGELLEFAKLGSYLEYDLFGTEMLNYPYNLDVDMPSDSQRVKALAFLVKEGYEDKIVIAHDIHTKNRLTKYGGHGYSHILKNIVPKMLTRGISQHQVDKILIDNPKCWLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DG31</accession>
    <name>A0A3P9DG31_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemokine interleukin-8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DG31"/>
    <dbReference type="Ensembl" id="ENSMZET00005034833.1">
        <property type="protein sequence ID" value="ENSMZEP00005033660.1"/>
        <property type="gene ID" value="ENSMZEG00005025163.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287013"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018045413" description="Chemokine interleukin-8-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="3">
        <location>
            <begin position="39"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="94" mass="10411" checksum="9F8BD2FABEF7046A" modified="2019-02-13" version="1">MTVKILSITLLLLSVCKIPFLTFNLSGTRRRHPGRIPPCCPAVTKGNRTAEVVGETYREQAASGRCVKAIIFNTEYGQLCADPDAQWVKDRKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DG94</accession>
    <name>A0A3P9DG94_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuronal differentiation 6b</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Efficient DNA binding requires dimerization with another bHLH protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004542983.1">
        <property type="nucleotide sequence ID" value="XM_004542926.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DG94"/>
    <dbReference type="Ensembl" id="ENSMZET00005034910.1">
        <property type="protein sequence ID" value="ENSMZEP00005033725.1"/>
        <property type="gene ID" value="ENSMZEG00005025218.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472195"/>
    <dbReference type="KEGG" id="mze:101472195"/>
    <dbReference type="GeneTree" id="ENSGT00940000159827"/>
    <dbReference type="OrthoDB" id="10039134at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000006">
        <property type="entry name" value="Neurogenic differentiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022575">
        <property type="entry name" value="NeuroD_DUF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF9">
        <property type="entry name" value="NEUROGENIC DIFFERENTIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12533">
        <property type="entry name" value="Neuro_bHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="340" mass="38566" checksum="96DA9CF071DCFE6B" modified="2019-02-13" version="1">MLTRGNMLTLPFEEPHIMCEPRFGANYPRESLPESLEQERQHNPDRSNSDMREIEDDISDRDEDEREDDQDENGLPKKRGPRKKKPGKEQVDRAKLRRQEANARERSRMHGLNAALESLRKVVPCYSKTQKLSKIETLRLAKNYIWALSETLSAGKRPDLLAFVQTLCKGLSQPTTNLVAGCLQLNARNFLTDHNGEVMFSGRAPYDAMYPYPGSDMNTPPGHSGSSLDSSAKPFRHYSYSSAYEPYYENQSPESGSPHFDGQLSPPMNFNGIFSLKHDDPPEYGKNSHYGMRYCGAPGRTALAHNSMYRVSPEARFPYDLHVRSQSFQAQGEVNGSFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGX7</accession>
    <name>A0A3P9DGX7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGX7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033422"/>
    <dbReference type="Ensembl" id="ENSMZET00005034552.1">
        <property type="protein sequence ID" value="ENSMZEP00005033422.1"/>
        <property type="gene ID" value="ENSMZEG00005024951.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282522"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF180">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="282" mass="32059" checksum="1B9BCD0C2E29AEAA" modified="2019-02-13" version="1">MSFFESDDASTLVLVGKTGVGKSSSGNTILGKDVFRAATVTAECSKQQEKLFQRTISVVDTPGLFDTTMSEDAVKREISKCINMSAPGPHAILLVIRVGRFSAEERDAVKKVEEIFGEGAWRYTMILFTHGDKVKADFDHMLKTAGTELQEVLRKAENRYHVFNNLRANDRGQVLDLLKKVDKMVADHGGEFYSNYTYLQVEEMLKQRESELREFYEKKLKEEIKAVKLKYEKKLKERYYLALASGVRQFVEQVAKDAELSCSHFLSRLKVHSHPSSVLFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHA5</accession>
    <name>A0A3P9DHA5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHA5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034110"/>
    <dbReference type="Ensembl" id="ENSMZET00005035308.1">
        <property type="protein sequence ID" value="ENSMZEP00005034110.1"/>
        <property type="gene ID" value="ENSMZEG00005025494.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157151"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000019">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase kappa isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000009">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000048">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000025">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF10">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE U-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="119"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="217"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="315"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="422"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="838" mass="93287" checksum="92EC3C6B0EB209D0" modified="2019-02-13" version="1">MLVNSSQHAVGHRAQLLLQTLSENDTHCVQFSYFLYSRDGHSPGALRAYVRVNGGPLGSPVWNTSGPHGKQWHQVELAVSTFWPNEYQVLIEATVSKERRGYIAIDDIMVLNYPCYKAPHFSRLGDEEVNAGQNATFQCVAAGRASEAEKFLLERHNGDILTMASVKHLSHRRFVVSFQLDSVQRTDQDLYRCVTQSPRGSGVSNFAELVVKVPPSPIAPPQLLRAGSTYLIIQLNTNSILGDGPIIRKEIEYRASQSPWSEVHGVNMVTYKLWHLDPDTEYHISVLLTRPGEGGTGPPGPPLVSRTKCAEPMRALRGLAATDIQPRQLSLQWENLAFNLTRCHTYSVSLCYRYTMAGGGGGHNTTVRECLAVEHNASRFTLRDLPPYHAIHVRLSLANPEGKKEGREVTFQTEEDIPGGIAPESLTFTPLDDMIFLKWEEPVEPSYEISYQSIESSDPSINVPGPRRTVSKLKNETYHMFSNLHPGTTYLISVRARTAKGFGQTALTEITTNISAPTFDYGDMPSPLSETESTITVLLRPAQGRGAPVSTYQVVVEEETGKKVKRELGVQECFPLPMSHGEAQARGTPHYYTAELPPSSLPEASPFTVGDNHTYNGYWNSPLDPRKSYLVYFQAMSNFRGESRINCIRIARKAACKDHRKALEVSQHSEEMGLILGVCAGGLVVLILLLGAVIIIIKKGDYYSYYPKPGNMNKTPITYRQEKSHMGSMERSFTDQSTLQEDERMALSFMDSHTCGDARSSVNEASSLLGGSPRHQCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYEVKGSIRRKHNPENKQHFQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHV3</accession>
    <name>A0A3P9DHV3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TLC domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="entry name" value="CT120 PROTEIN"/>
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        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN"/>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Aken B."/>
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                <person name="Baroiller J.F."/>
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                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
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                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIS3</accession>
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        <submittedName>
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004542527.1">
        <property type="nucleotide sequence ID" value="XM_004542470.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIS3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034303"/>
    <dbReference type="Ensembl" id="ENSMZET00005035508.1">
        <property type="protein sequence ID" value="ENSMZEP00005034303.1"/>
        <property type="gene ID" value="ENSMZEG00005025643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476944"/>
    <dbReference type="GeneTree" id="ENSGT00940000164939"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06968">
        <property type="entry name" value="NR_DBD_ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000003">
        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044101">
        <property type="entry name" value="NR_DBD_ROR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003079">
        <property type="entry name" value="ROR_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF7">
        <property type="entry name" value="NUCLEAR RECEPTOR ROR-BETA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01293">
        <property type="entry name" value="RORNUCRECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="252"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="105"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="502" mass="55404" checksum="35DC5D32A5BF49C3" modified="2019-02-13" version="1">MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNAMYSCSRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQKSQECVGSGSGGSATLSLPREDGVCGSGGEDGEEGLSRSYSSGGSSSTLSDLDDIAALPDLFDLPLTPEEASEYCSLELLGGGGASAGNTSNSSSSSSTSSSMSNQNSPQQTMLDGADSNGIQLLHSHTHSLLGHTHALLDQLPDDCSITDLEHITQSIVKSHLETCQYSAEDMKRFNYVQYTPEEMRTFQNKSAEWMWQQCAHHITNAIQYVVEFAKRIAGFMDLCQNDQIILLKAGCLEVLLIRMCQAFNSSNNTIFFNGKFASAQFFKALGCDDLVSAVFDLGKGLCRLQLSDDEMALFSAAVLLTPDRPWLTEGQKVQKLQEKVYLALQHSLQKSGASDEKLDNMLSRLPVMKSICNLHIDKLEFFRLVHPETAYSFPPLYREVFGSEISLPDSTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DKC6</accession>
    <name>A0A3P9DKC6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase 2, mitochondrial</fullName>
            <shortName evidence="7">AK 2</shortName>
            <ecNumber evidence="7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-AMP transphosphorylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AK2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + AMP = GDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:29863"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="7"/>
    <dbReference type="RefSeq" id="XP_024654111.1">
        <property type="nucleotide sequence ID" value="XM_024798343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DKC6"/>
    <dbReference type="SMR" id="A0A3P9DKC6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034818"/>
    <dbReference type="Ensembl" id="ENSMZET00005036058.1">
        <property type="protein sequence ID" value="ENSMZEP00005034818.1"/>
        <property type="gene ID" value="ENSMZEG00005026032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="112430163"/>
    <dbReference type="GeneTree" id="ENSGT00940000154576"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Adenyl_kin_sub"/>
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        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
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        <property type="entry name" value="AK2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK00279.1-2"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="48"/>
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        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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        <location>
            <position position="53"/>
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        <ligand>
            <name>AMP</name>
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        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>AMP</name>
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        <location>
            <position position="109"/>
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        <ligand>
            <name>AMP</name>
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        </ligand>
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        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <location>
            <position position="177"/>
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        <ligand>
            <name>AMP</name>
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        <location>
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        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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        <location>
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        <ligand>
            <name>ATP</name>
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        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003330"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05191"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="243" mass="26586" checksum="BB9A2955115CCD5D" modified="2019-02-13" version="1">MAPSTQLKEAIADVQDGIRAILLGPPGAGKGTQAPRLAEKYCVCHLATGDMLRAMVASGSELGKRLKETMDSGKLVSDEMVVELIEKNLESPACRNGFLLDGFPRTVKQAEMLDDLLDKRDEKLDSVIEFSVDDSLLVRRICGRLIHQPSGRSYHEEFNPPKESMKDDVTGEPLIRRSDDNENTLRSRLEAYHRQTSPLVQYYSARGLHTAVDAAQNPNVVFASIVAAFSAATEMPARATASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSI8</accession>
    <name>A0A3P9DSI8_9CICH</name>
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        <recommendedName>
            <fullName evidence="2">Short myomegalin-like EB1 binding protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005027758.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:molecular adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:centrosome cycle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of microtubule nucleation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of Golgi organization"/>
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        <property type="entry name" value="MT-associated_AKAP9-binding"/>
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        <property type="entry name" value="SMYLE_N"/>
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        <property type="entry name" value="MYOMEGALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SI:CH73-95L15.5"/>
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        <property type="entry name" value="SMYLE_N"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Short myomegalin-like EB1 binding protein N-terminal" evidence="2">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18615"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="488" mass="55085" checksum="E190AC5E6B63D299" modified="2019-02-13" version="1">MSSRSKKDQCQICGGALQGNQRRWLSPSKSVDLLTVLTHILGQSVPRGGGQGEFVCGKCVCLLERVFKFDTVIARVRVLSSERLQKLTHERDKIRQWVRQNYCHRHLQDFQSRSSTSEEEGEVEKEGYREMLKENMALSEYECWSEKWDTCPYFIRTGKRCRKGKGCEGCDSLRVSDSDYESVCGVPRHMPFQPFSPLSQDRSQSVPLHWQRVPSVNSSPASLAGSSLSLRAPSHTESIQSLDSLDGNDPFDSASDQSVNFMLRELRSIGGKPVSSPSGSKIPVLGKRDGRYLGKIEETASPTVTRVLNFRDVENGGDEENGDVLTLLRDEFMPLHPFVSLKGWKYCDGHFLLSSKLCLFSVDKLIVSFSDLQAALEALRSEITEKEKSMEKEIEALWKAGRDRERDLDTLNTVLQCNQDIISVRPHTATRVVSCLAVTLFLFDTRLEMQDNSGNIKQSCQLLSCCLFCRHAHSYIAHILICLFGYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSM3</accession>
    <name>A0A3P9DSM3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin/ISG15 ligase TRIM25-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSMZEP00005037454.1"/>
        <property type="gene ID" value="ENSMZEG00005027931.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286931"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
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    </dbReference>
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        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50119"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037454.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="294" mass="33370" checksum="B0E1C93267DD49F9" modified="2019-02-13" version="1">MAQKGVQLDQETFSCSICLDLLKEPVTIPCGHNYCMNCINGFWDGEDEKKIYSCPQCRQTFTARPVLVKNTMLTILVEELKKTGLQAAPADHCYAGPEDVACDFCTGREMKAVKSCLVCLVSYCEKHLQPHYDVAPLKKHKLVEPSKKLQENICSRHDEVMKMFCRTDQQSICYLCSVDEHKGHDTVSAAAERTERQRELEVSRQNIQQRIQDREKDVKLLQQEVESILGLDHWGTKILYSGFCKALDCLEGLLFGLRMTRGGQQCASSTRNSNRRSIAEMTSLKLHNKQTTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ART8</accession>
    <name>A0A3P9ART8_9CICH</name>
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        <name type="scientific">Maylandia zebra</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_014262763.1">
        <property type="nucleotide sequence ID" value="XM_014407277.3"/>
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    <dbReference type="Ensembl" id="ENSMZET00005000157.1">
        <property type="protein sequence ID" value="ENSMZEP00005000117.1"/>
        <property type="gene ID" value="ENSMZEG00005000168.1"/>
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    <dbReference type="KEGG" id="mze:101487872"/>
    <dbReference type="GeneTree" id="ENSGT00940000168028"/>
    <dbReference type="OrthoDB" id="10072641at2759"/>
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        <property type="component" value="LG6"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
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        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
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        <property type="entry name" value="RRM_dom"/>
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        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
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        <property type="entry name" value="ZnF_U1"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ZF_MATRIN"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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            <begin position="1510"/>
            <end position="1541"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AS47</accession>
    <name>A0A3P9AS47_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AS47"/>
    <dbReference type="Ensembl" id="ENSMZET00005000605.1">
        <property type="protein sequence ID" value="ENSMZEP00005000540.1"/>
        <property type="gene ID" value="ENSMZEG00005000499.1"/>
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        <property type="component" value="LG18"/>
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    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:activation of innate immune response"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RBD_ZCCHC3_1st"/>
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        <property type="entry name" value="RBD_ZCCHC3_2nd"/>
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    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
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    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
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    </dbReference>
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        <property type="entry name" value="RBD_ZCCHC3_1st"/>
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        <property type="entry name" value="RBD_ZCCHC3_2nd"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="342" mass="39006" checksum="3A423C6454CFCE7E" modified="2019-02-13" version="1">MPFSEQYPVIYKVVIRLLKRFPNKITSQEITRATIEEILFPTVSMSLIEKLREIHTKMAWGNVNNKFLLNSHKNLAWQAAQECLPTRAFLPTMATSTANMTGSRRNAVRFEMQGNCKRDRLHFSRIVIQKELGFSPTQIDYIFGLPGKKSYEVIFATNTLFESCIDKFNRLKQSRPQLENIKRTALSGSEPKAVTVIMHSEYVRGEDIKIWLSFKCVVMRGLDLKDKDGIRTGAYRFYVHLHRDENSGDLTHLPPIIQLGAIRGYVFYAGQPKTCRKCGGNDHLAAECDNVVCKNCNSDEHIARKCNLCGGEGHNFRACPQSYANRVKRPQLHSTRNHASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVH6</accession>
    <name>A0A3P9AVH6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ig kappa chain V region GOM</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVH6"/>
    <dbReference type="Ensembl" id="ENSMZET00005001498.1">
        <property type="protein sequence ID" value="ENSMZEP00005001408.1"/>
        <property type="gene ID" value="ENSMZEG00005001179.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005001510.1">
        <property type="protein sequence ID" value="ENSMZEP00005001420.1"/>
        <property type="gene ID" value="ENSMZEG00005001179.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005001512.1">
        <property type="protein sequence ID" value="ENSMZEP00005001422.1"/>
        <property type="gene ID" value="ENSMZEG00005001179.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005001515.1">
        <property type="protein sequence ID" value="ENSMZEP00005001425.1"/>
        <property type="gene ID" value="ENSMZEG00005001179.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005001520.1">
        <property type="protein sequence ID" value="ENSMZEP00005001430.1"/>
        <property type="gene ID" value="ENSMZEG00005001179.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153770"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002525">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044597110" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="119" mass="12937" checksum="1152B09C7AA04B0B" modified="2019-02-13" version="1">MMMSLTLLLATLGLLVQGLSGEKVLTQTPKAQSVVLGQTVSVRCKASSSVSNNLHWYLQKDGESPKLLIYHATNRQSGVSDRFSGSGSGTDYTLTISRVQAEDAGVYYCQQCNSWPFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWA3</accession>
    <name>A0A3P9AWA3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 20">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 20">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:11581"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:11582"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20 21">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 20"/>
    <dbReference type="RefSeq" id="XP_004556513.1">
        <property type="nucleotide sequence ID" value="XM_004556456.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWA3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001707"/>
    <dbReference type="Ensembl" id="ENSMZET00005001801.1">
        <property type="protein sequence ID" value="ENSMZEP00005001707.1"/>
        <property type="gene ID" value="ENSMZEG00005001404.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482332"/>
    <dbReference type="KEGG" id="mze:101482332"/>
    <dbReference type="CTD" id="10423"/>
    <dbReference type="GeneTree" id="ENSGT00940000154169"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 20" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 20" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="212" mass="23676" checksum="E56E211B77BFA9FA" modified="2019-02-13" version="1">METENIFLFVPNLIGYARVVLALISFFLMPCCPWPAVFCYLLSALLDAFDGHAARALNQSTKFGAMLDMLTDRCATMCLLVNLSLLYPSYAFLFQLSMCLDIASHWLHLHSSTVKGSASHKTIDLSGNAILRLYYTSKPVLFVMCAGNELFFCLLYLLYHIEEPAGWLYWLQGLCGIICLLKSGISVLHLITASKNMAAIDAAEREKALKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWG2</accession>
    <name>A0A3P9AWG2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Beta-glucuronidase</fullName>
            <ecNumber evidence="5 12">3.2.1.31</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Plays an important role in the degradation of dermatan and keratan sulfates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:17633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:83411"/>
            <dbReference type="EC" id="3.2.1.31"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Inhibited by L-aspartic acid.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.31" evidence="5 12"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWG2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001969"/>
    <dbReference type="Ensembl" id="ENSMZET00005002067.1">
        <property type="protein sequence ID" value="ENSMZEP00005001969.1"/>
        <property type="gene ID" value="ENSMZEG00005001560.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001752"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019391">
        <property type="term" value="P:glucuronoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000027">
        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000628">
        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000029">
        <property type="entry name" value="Beta-glucuronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007538">
        <property type="entry name" value="PRK10150.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10066:SF67">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10 12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018062033" description="Beta-glucuronidase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="16">
        <location>
            <begin position="41"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="14">
        <location>
            <begin position="227"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="15">
        <location>
            <begin position="330"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003025"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="647" mass="74423" checksum="10277C598BC08488" modified="2019-02-13" version="1">MSVPGSSAVLRVLWLLSVFGTVLPLDGGMLFPRESTSREVKELNGLWDFRPDGSLNRNEGFEKAWYKRRLAETGPVIEMPVPASYNDITQDPTLRDFIGWVWYEREVFVPARWISDEGTRVVLRVGSAHYYSIVWVNGEKVTEHEGGHLPFEAEISSLIRRDPTKPCRITIAVNNTLTLETLPPGTIQYMNDRTRYPDGFFVQNIYFDFFNYAGIHRPVLLYTTPTVYVDDIIVETNFMDNTGLVRYKVSVQGAATATLKVTLMDKDGHCVASSNTPSGVLKVVDVKLWWPYLMHENPGYLYSMEVHLIAVSETSTYEDVYTLPVGIRTVNVTKTQFLINNKPFYFHGVNKHEDSDIRGKGLDWPLIVKDFNLIKWLGANSFRTSHYPYAEEILQMCDRHGIVVIDECPGVGIKDIRSFGNASLSHHLVVMDELVRRDKNHPSVVMWSVANEPASEMPPAEFYFKTLIKHTKALDHTRPVTYITDSNYARDKGAPFVDVVCVNSYFSWYHDPGHLEVIPIQLNAQFENWYGKYKKPIIQSEYGADALPGLHMDPPMMFTEEYQNALLQSYHDVFDQKRKQYVIGELIWNFADFMTAQAIHRVVGNKKGIFTRQRQPKAAAFILRRRYWRLANETWRLPPWTKYPCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWH9</accession>
    <name>A0A3P9AWH9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004572651.1">
        <property type="nucleotide sequence ID" value="XM_004572594.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWH9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002051"/>
    <dbReference type="Ensembl" id="ENSMZET00005002150.1">
        <property type="protein sequence ID" value="ENSMZEP00005002051.1"/>
        <property type="gene ID" value="ENSMZEG00005001664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471265"/>
    <dbReference type="KEGG" id="mze:101471265"/>
    <dbReference type="CTD" id="254225"/>
    <dbReference type="GeneTree" id="ENSGT00940000153680"/>
    <dbReference type="OrthoDB" id="8959987at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051657">
        <property type="entry name" value="RNF168/RNF169_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="585" mass="64507" checksum="9791EB4414C71378" modified="2019-02-13" version="1">MATAGSAERPGRPASATAAGTSRAGLAARCRSGSSPPEYESKKCMACAETGGSPAGRHLACPLCLAPRHSGSEERLRGRSDHESSSSRPGGRDCDSRREFFVSPVLIPKSADAPSGPSGKHKLLLCDDREEVKRRSSLNCKDESVRRDEDPGVLSDSENEEPISRRIRNISAFIRKTKNSSAGSCQRSRSCTDPVEDGGGKMKLVTQPAAVMDRVGISHSYAAGILLSSENSRSISAPITAPDRRLTWRAVLTSSSSALLCMPPPRPERSISPESNDSISEELNHFKPIVCSPCTPPKRLPDGRLMEPTIVKSTPRNLTRGLQKATSYEASPAVLQKWRQIELDRQSLKVNSKATLTSPVSEVNHNKLGMGGEGAKTRQSPAGDAVTSANKRRLLFDSPAGDTDSFQKQSVKIRVPAVRYSSESTFKGGFEPPAGTPESCSTGALFSRKQSFSPYTKNSGVQSCKLVPKDSQSPRKESDSSIHNQTTSRRGKKRKQKTKHLDSSRDLDLKRGRPVNQEALDERYICQIQQERQDRALALKLQRQFDRENQNRRRSPDKYFLRSWMSTQSRRRRGLRRSRRINKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWU7</accession>
    <name>A0A3P9AWU7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C-terminal-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561239.2">
        <property type="nucleotide sequence ID" value="XM_004561182.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWU7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002109"/>
    <dbReference type="Ensembl" id="ENSMZET00005002209.1">
        <property type="protein sequence ID" value="ENSMZEP00005002109.1"/>
        <property type="gene ID" value="ENSMZEG00005001655.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101467118"/>
    <dbReference type="GeneTree" id="ENSGT00940000166669"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001383">
        <property type="entry name" value="C-terminal-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF3">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="16">
        <location>
            <begin position="633"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="17">
        <location>
            <begin position="730"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1000"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1007"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1034" mass="110966" checksum="CE79D797533547A4" modified="2019-02-13" version="1">MPNSSEQSCFGGSLSQRGPEWSEGQNDRAASRCHYCGNIAGCRNSSALCGEDGDVWFHGHLDLGEKRDPVLHSSLYRQIQQDQHGQPPLKKTSVPDLSSSLYLKELMAGRASAPPQDYYLTDATLSGHPPKESGFYRDNQHLLTRSALHYGPSVGGVRSSWDQGQARATPSLLASASTPTPAPLPPPPPPPPPPPPPPPPLHELSRLYRETLGSKMIPDVQRIGGSSPATAIFGAQPPLPVYAAEPLSARQTYNSINSLRLDPLQPAATSSLVDPASQGMDAAFPRAYGAVASQRLPYDPNYDPSSAMVAATAGMVSTLPPHQPSAADPKKMVDPAFLAFLRGEGLAESTITLLLQHGFDSLSTLGMMEDHDVRSVAPNLAQARVLSRVVLSCKTVGTATRARSNSFSHRNDLYVQPQGLTMDPNLMQQPPTTVQTVSPRMGEFLGRRPSSAPSQHLLETTTYPGARPLAPGAFPVSPGGYSSAVTQGRPFSMYNAHTGLAMSALGNQPPPAPGTPGAAPKTFSGSYSPMELMKRAPNFPPASPVGAASPLHSPQLLRKGINAAPESTIVPVSSATTLQAQNLNNNKMVGRRTGPPVIVSTMVTTPDTSIRPQIMNGPMHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRIIIRIGSGYDNIDIKAAGELGIAVCNIPSAAVEETADSTLCHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRSGQAVAVRAKVFGFNVIFYDPYLQDGLERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHETEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPDSLRNCVNKEFFVTTAPWAVMDQPGVHPEHNGAAYRYPPGVVGVAPGGIPGALEGMVPGGVPIAHTLPSGTHPSQAPSPNQPSKHGDTREHLTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWU8</accession>
    <name>A0A3P9AWU8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWU8"/>
    <dbReference type="Ensembl" id="ENSMZET00005002233.1">
        <property type="protein sequence ID" value="ENSMZEP00005002133.1"/>
        <property type="gene ID" value="ENSMZEG00005001693.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166432"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF114">
        <property type="entry name" value="PCDH2G3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="98"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="211"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="292"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="416"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="646" mass="70727" checksum="AB80C0B41620AC3F" modified="2019-02-13" version="1">MLNTSAEKGTRFRIEGAHDADIGKNSVQRYSLQKNDNFILMVDANNVELVLDHKLDRETQREINLPLTAVDGGSPQRSSTVMIHVTVLDANDNAPVFSQAVYKASIPENSPLNTVVVRVSATDADEGVNGEVSYDFGHVSDIDEKVFSIDFKTGEIRVIGATDFEKKNAFELPVIANDGLGLSSSAKVYIELTDENDNAPVVYLKSLSNPIPENAQTGTEVGIINVQDRDSENNRQVRCSIQQGVPFKLVPSIKNYYSLVTTGQLDRELVSDYNITITLSVADINDNPPVFEEQSYSAYVSENNKPGSTLCSVSARDPDWRQNGTVVYSLLAGEVNGAPVSSYLSVNGDTGVIHAVRSFDYEQFRSFKVHVMARDNGSPPLSSNVTVSVFISDVNDNSPQILYPSPEGNSFMTELVPKAAHGGSLVSKVIAVDADSGQNAWLSYQIVKSTDPGLFTIGVHSGEIRTHRDISESDSTKQNLVVAVKDNGQPSLSATCSMYLLISDNLAEVPELKDLSYNESNSKLTSYLIIALASVSTFFLTFIIIILGLRFCRRRKPRLLFDGAVAIPSGYLPPNYADVDGTGTLRSTYNYDAYLTTGSRTSDFKFVTSYNDNTMQTLGKINRSAAPFSRVSPLSWFLLLKTIILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXB8</accession>
    <name>A0A3P9AXB8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="10">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004572634.1">
        <property type="nucleotide sequence ID" value="XM_004572577.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXB8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002335"/>
    <dbReference type="Ensembl" id="ENSMZET00005002441.1">
        <property type="protein sequence ID" value="ENSMZEP00005002335.1"/>
        <property type="gene ID" value="ENSMZEG00005001832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466969"/>
    <dbReference type="KEGG" id="mze:101466969"/>
    <dbReference type="CTD" id="83939"/>
    <dbReference type="GeneTree" id="ENSGT00730000111053"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000149">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="12">
        <location>
            <begin position="215"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="580" mass="64107" checksum="1F56C1DB5A4618FA" modified="2019-02-13" version="1">MAPPVPLLAVRGSDGTSLLRGPPHCEPHAAFQRDCRPSRCVTFSTDGTLFGWCNGQNVSIVNPSDGAVVSTFDLPKTALLEFSPLNNILVTWQLYTKTQDSPQGEANLQLWELRSGRLIKALYQKKVESWCPSWSEDEKICVRIVNNELHFYEDNDFDSIANKLHMQKVSDFALSPGGQPSKVAVYVPGSKGAPSFVRLYQYPAFGGPTAALANKSFFKADRVMMQWNKKASAVLVTASTEVDKTGASYYGEQTLHYLGVNGETALVQLSKNGPIYDVAWSPSSTEFCVVYGFMPAKATVFNLKCDPVYDFGTGPRNAAYYSPQGHILILAGFGNLRGQMEVWDVKNYKQVSKSQAPDATHFSWCPDGEHIVTATCSPRLRVSNGYKIWHYTGSVLQKWDVAAGSELWEVRWQSLPDGSFPKRPIKYQAAPSQLGSTQAPPTQAYRPPALRHLPATPSSKLHEDEPPQDLRPGASGEKSLSKSALKNQRKREAKKAAKQEAKPEPEPPTDPAAVSNSQSEASIGDPEVEKKIKNLKKKLKAIEELKEQQASGKVLQKNQVEKIQKEEQLLKELQELQIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2A4</accession>
    <name>A0A3P9B2A4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2A4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004053"/>
    <dbReference type="Ensembl" id="ENSMZET00005004220.1">
        <property type="protein sequence ID" value="ENSMZEP00005004053.1"/>
        <property type="gene ID" value="ENSMZEG00005003124.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155060"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="BASIGIN RELATED"/>
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        <property type="entry name" value="CELL ADHESION MOLECULE DSCAM2-RELATED"/>
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            <begin position="134"/>
            <end position="160"/>
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            <begin position="1"/>
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            <dbReference type="ARBA" id="ARBA00023319"/>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004053.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="202" mass="22327" checksum="6D2DC8F4ACC2BB2D" modified="2019-02-13" version="1">MGHRQRKKVESGFCLSKKRTDKPNSLISPFSGGCLPSFVKSPEDQTGISGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGSGSVLRIQPLRTHRDEAIYECTATNSAGEINTSAKLTVLEGKISLLLFPLGFSLHTCFHCGPFFFLLLVVFKSFMSIYKEIGVFALIIHTYEIGEIPGIALAKEEQQYLNLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2G1</accession>
    <name>A0A3P9B2G1_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the peptidase A1 family.</text>
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        <property type="component" value="Unplaced"/>
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            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="151" mass="16758" checksum="E550BB2A984EA83C" modified="2019-02-13" version="1">MTGFLGYDTVTVAGLTVTNQIFSLSQTEAPFMQYMQADGILGLAYPSLPLVRHLSHKYYAGFYLTLEIIYRSRSQNGEYMVSCNNIDQMPDVTFNINGQQFTLPASSQSYGCLTGFSGQGSNLWILGNVFLGQYYSIFNRGQKTVGLAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2N3</accession>
    <name>A0A3P9B2N3_9CICH</name>
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        <submittedName>
            <fullName evidence="5">R3H domain containing 1</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_014413145.3"/>
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        <property type="gene ID" value="ENSMZEG00005003157.1"/>
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        <property type="protein sequence ID" value="ENSMZEP00005004170.1"/>
        <property type="gene ID" value="ENSMZEG00005003157.1"/>
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        <property type="component" value="LG23"/>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="R3H domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="R3H-like domain"/>
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        <property type="entry name" value="R3H_dom"/>
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        <property type="entry name" value="R3H_domain_containing"/>
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        <property type="entry name" value="SUZ"/>
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        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
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        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="157"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
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            <begin position="221"/>
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        <location>
            <begin position="892"/>
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            <begin position="38"/>
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            <begin position="99"/>
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        <location>
            <begin position="319"/>
            <end position="331"/>
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        <location>
            <begin position="381"/>
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        </location>
    </feature>
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        <location>
            <begin position="392"/>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51061"/>
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            <dbReference type="PROSITE" id="PS51673"/>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113465" checksum="6A556D2C6AF5CE87" modified="2019-02-13" version="1">MRMSDNVDTETMKVSEAAEPASSAKDAKTEVSDQSQNSRDEHGCNNKKDIQPVKYSKSNTRLKLVRSLAVCEESFPCPIPEPSAAPQDGFLLQPFEKEERAAQVQAEKEENYDKADKPEKTQKKMLSRDSSQDYTDSTGIDLHEFLVNKLKGNPRDRIMLLKLEQDILDFISNNESQKRKFPPMTPYHRMLLHRVAAYFGMDHNVDPSGKSVVINKTTNTRIPDQKFSEHIKDDRADDFQKRYILKRDNSSFDREDSTIRMRLKADKRSKSMEEREEEYQRARERIFAHDGDHFILDRSAQDEDACMSTQQRRQMFRLRAGQSGASRQSSSETEALPRHGEPRPWSSTDSSDSSNRLAPRPAITKASSFSGISPVLVRGDSTASSKSTGRLSKTGSESCSSVGSSSSSLSRPQLPLPVSTSSRSNVPSAPLIHPAADARGAGHPEMTKSLLSQPPPATDAANYYLLPLEASGIPPGSVLVNPHTGKPFIHPDGSAVVYNPASIAPAAGRIQQQGKPPQQPVPATVQQQPTNHLHSQPICPPLQPPSEPVHNPMVSSYPLPPPPLPPSQFLPVCPNQQYTVPDSLNAQFSHMTLAQQPANDSGPSAPDGRHYPSVYHHHHPSAVVLQGTPPQQVASYIVAGPSGGHPGVLQGQPIPLPTPAQNHTYPSSALGHAAFPGSALNQPLLQQHTYIQQPVQQMSSCYCSSTHHPHCSSTQQQQHYRPPVSTLPYNCPQSQNLPQQQVHQAVMPNPASSYQTVVGVQPTPNLAFTGNQQSNMGNQMQGMMVQYPPMQSYQQVSVPQQTYQQPVFVSCQPGQGAVAVAGMQPCYSLLPPNQHTTMSSTVSFLPTPMMEQLQFPQTSSPCVSQQHPGQQYAGLLPPAPSSGMVMLQMTAAPCQQPRAPSPCQRKPLSHKHLGPEHQRNRRPAELPPLPDNTQSSLPSSPALTPSPGQPPSVKGLPTGISPIPVMAHHPQLPTAFCHSGQGEAHYSLLGQPLQYKPSIRPPFIHTAHMMAKHQVPLGVWRGSHGRKAGRKSVSSDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2X7</accession>
    <name>A0A3P9B2X7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550434.2">
        <property type="nucleotide sequence ID" value="XM_004550377.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2X7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004265"/>
    <dbReference type="Ensembl" id="ENSMZET00005004444.1">
        <property type="protein sequence ID" value="ENSMZEP00005004265.1"/>
        <property type="gene ID" value="ENSMZEG00005003308.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463627"/>
    <dbReference type="CTD" id="321590"/>
    <dbReference type="GeneTree" id="ENSGT00940000156068"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000036">
        <property type="entry name" value="septin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="39"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="321"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="474" mass="54721" checksum="30883EED2923A19F" modified="2019-02-13" version="1">MAATDVDVFSNEEKRNLSLGGHVGFDSLPEQLVSKSVTQGFCFNILCVGETGIGKSTLMNTLFNTMFENEEASHYQNGVYLRPRTYDLQETNVRLKLTIVDTVGFGDQINKEDSYKPIVDYIDTQFENYLQEELKIKRSLFNYHDTRIHICLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMSELVSNGVQIYQFPTDDETVSEINASMNAHLPFAVVGSVEEVKVGNKAVRARQYPWGVVQVENESHCDFVKLREMLIRVNMEDLREQTHARHYELYRRCKLEEMGFKDTDPDSEPFSLQETYEAKRKEFLGDLQRKEEEMRQMFVNKVKETEAELKDKERELHEKFEQLKRMHQEEKKKVEDKRGYLEEEMNAFNKRKAAAETLSLSQPVKKDKDKKKSVNMENQSGVSASSSKVMMAKANVEPLNCQSWWQAIQCCTCLVHNATWRPGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3L6</accession>
    <name>A0A3P9B3L6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3L6"/>
    <dbReference type="Ensembl" id="ENSMZET00005004703.1">
        <property type="protein sequence ID" value="ENSMZEP00005004500.1"/>
        <property type="gene ID" value="ENSMZEG00005003428.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012182"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033615">
        <property type="entry name" value="EOLA1/EOLA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31666">
        <property type="entry name" value="PROTEIN CXORF40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31666:SF0">
        <property type="entry name" value="PROTEIN EOLA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="151" mass="16549" checksum="B8B81AA576486C8B" modified="2019-02-13" version="1">MCRQHSQSQQESGILSEQPARNVLDDCHASKPVKHVETAVHPQLNTSVNDKVAQRDWEGSEWRAVLSGLLGMDSAQIEALLESREQFGHGVVAGLVDVGQTWLCPASLQGKDLQCLEQSAVLIGLQEKHLTNLSNPRWLKAPLRAPGGRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5E6</accession>
    <name>A0A3P9B5E6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5E6"/>
    <dbReference type="Ensembl" id="ENSMZET00005005324.1">
        <property type="protein sequence ID" value="ENSMZEP00005005100.1"/>
        <property type="gene ID" value="ENSMZEG00005003944.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000223460"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="231" mass="25653" checksum="460EFF6697544314" modified="2019-02-13" version="1">PNRCIILFFFRGDMPGKGDQPRRSKGQLGGTKLRGTRGILGLPGDLEGRNTSPTEDAEALIRTESDEQTLIRAESDEQTVIRAESGEQTVIRTESDEQTVIRAESDEQTVIRTESDKQTVIRAESDEQTVIRAESGEQPVIRAKSDEQPVIRTESDEQTVIRAESGEQTVIRTESGEQTVIRTESDEQTVIRTESDEQTAHIRCCNTKNFGDLRLAFAVVVELSRSSEGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B724</accession>
    <name>A0A3P9B724_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B724"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005703"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:intracellular protein transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="AP complex subunit sigma"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AP_complex_ssu"/>
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    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
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    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AP_complex_sigma"/>
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    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="9">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="138" mass="16290" checksum="85C0DD9D0900CDF6" modified="2019-02-13" version="1">MIKFVLMVNRQGQTRLSRYYHSVELSRRAALEADVVRYCLSRKKDQCSFVEYKDFKLVYRQYAALYIVVGITDSELSIYELVHNFVEVLDKYFSRVIMFNLDRVHIILDEMIQNGHIVETNKSRILAPLTTIDKMVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B968</accession>
    <name>A0A3P9B968_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P2Y purinoceptor 1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B968"/>
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        <property type="protein sequence ID" value="ENSMZEP00005006458.1"/>
        <property type="gene ID" value="ENSMZEG00005004989.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155094"/>
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        <property type="component" value="LG5"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="NPS_rcpt"/>
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    <dbReference type="PANTHER" id="PTHR24244:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEUROPEPTIDE S RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="342" mass="38891" checksum="1BD600091B89CEE0" modified="2019-02-13" version="1">MREMSVNNTKGPCEGNLINLNFTHSFLPPVFITVFIVGTVSNICGLRSVCVSWKKNGNINIFMFNLGVADLLYLFTLPFLVYYYARESDWQFGQPFCKVTRFCFNLNLYGSIGFLTCISIYRYLGIVHPMKVMGKITSRHSLAISALVWVLVIIQITPDIFFDKNDEKKPNSCFDTTSTNLTRYYLPYSISWTVTGFVLPLVIILGCYGHIVVVLGKNANVNPLLKQRCLKLVVILVILFSVCFIPYHIFRNLNLTTRILKQDGLCHHLFDDIYIAHQVGRFLACLNSAINPLIYIVGNDDFLTKFQDFSNRTRMSLAGLKSAIIYRKPIEADYVTATDDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAJ5</accession>
    <name>A0A3P9BAJ5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAJ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006919"/>
    <dbReference type="Ensembl" id="ENSMZET00005007222.1">
        <property type="protein sequence ID" value="ENSMZEP00005006919.1"/>
        <property type="gene ID" value="ENSMZEG00005005307.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:postsynaptic density"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071787">
        <property type="term" value="P:endoplasmic reticulum tubular network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046964">
        <property type="entry name" value="RTN1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799:SF6">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45799">
        <property type="entry name" value="RETICULON-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU210713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="229" mass="24988" checksum="C85586C8778F25CD" modified="2019-02-13" version="1">MDPVTQSAQISSSQGFADGQNSATKESKLSAKDLIHWRDPKKSGVAFGLSLLMLLSLAAFSIISVVSYLLLALLCVTITFRIYKSVVQAVQKSNEGHPFKALIDKDVSIAPESFRKHVDASLTYINRALKQMSHLFLVEDLVDSLKVSSSELVSVGGGFLFLSRSTSPDLSLLTCCSLCFVGAMLTSNQVMVGSHLHPQNNPRIYDRVRTVSHISTPYPAAGKRRQICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BB02</accession>
    <name>A0A3P9BB02_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14 16">Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA, ORC1, cyclin-CDK. Interacts with HUWE1. Interacts with ANKRD17. Interacts with GRWD1; origin binding of GRWD1 is dependent on CDC6. Interacts with CDT1; are mutually dependent on one another for loading MCM complexes onto chromatin. Interacts with TTC4. Interacts (via Cy motif) with CCNF; the interaction takes place during G2 and M phase. Interacts with CDH1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562263.2">
        <property type="nucleotide sequence ID" value="XM_004562206.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BB02"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007079"/>
    <dbReference type="Ensembl" id="ENSMZET00005007387.1">
        <property type="protein sequence ID" value="ENSMZEP00005007079.1"/>
        <property type="gene ID" value="ENSMZEG00005005448.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101471117"/>
    <dbReference type="CTD" id="990"/>
    <dbReference type="GeneTree" id="ENSGT00530000063498"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000265">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000058">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="251"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="19">
        <location>
            <begin position="506"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="602" mass="65805" checksum="577C6632FA826408" modified="2019-02-13" version="1">MPSTRSQGRAQPTLQFPRRKSSRVSSRSKKPEPQKSPAVSPIKPEPQAPGLMRIGPLSPRRPINLSTPLSPRRYTDQPTPLSPTRPVALSSPLSPRRTSAQLPAPSSPRLQSRIPLSPRKRTGDDNVCNLGTSLQCSPTKQRKLSLASPRKLGFDENSPVQARRQLIPSSGQQTPPSTAKSSPKREETPTGSPIHKNLNKKPPVARLFGEKMRLQSVKQALHTAIPERLMSREAERASIRSFLEDKVLQHVPGSLYISGAPGTGKTACLNCVLQEMKAELSSVQTVMVNCMSLRSSHAVFPLLADKLKASGGQNGLQRFLTAPGPTVLLVLDEMDQLDSKAQDVLYTIFEWPYLPKSRLCLIGIANALDLTDRILPRLQARPQCRPLLLHFPPYSREELTAIVQDRLVQASAEGLLDASAVQFCARKVSAVSGDARKALDICRRAVEIVESDERKKASDPKGESKASRVSLPQVARVLSEVYGDRMASQSSGSEGESFPLQQKLLVCCLLLLIRYGKSKEIGLGKLHEVYSRLCAQRQVSGVGQGECLSLCSLLESRGIVALKKAKEARLTKVFLKIEEKDVENALKDRTLLGSILAAGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBH0</accession>
    <name>A0A3P9BBH0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="22">ADAM metallopeptidase with thrombospondin type 1 motif 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552686.1">
        <property type="nucleotide sequence ID" value="XM_004552629.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBH0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007131"/>
    <dbReference type="Ensembl" id="ENSMZET00005007439.1">
        <property type="protein sequence ID" value="ENSMZEP00005007131.1"/>
        <property type="gene ID" value="ENSMZEG00005005487.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472551"/>
    <dbReference type="KEGG" id="mze:101472551"/>
    <dbReference type="CTD" id="9510"/>
    <dbReference type="GeneTree" id="ENSGT00940000156815"/>
    <dbReference type="OrthoDB" id="412680at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013274">
        <property type="entry name" value="Pept_M12B_ADAM-TS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF40">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01858">
        <property type="entry name" value="ADAMTS1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018032950" evidence="20">
        <location>
            <begin position="23"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="21">
        <location>
            <begin position="221"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="15 18">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="16">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="325"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="342"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="535"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="539"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="948" mass="103213" checksum="7173E1D1A9583DD1" modified="2019-02-13" version="1">MMSFLPISISLIAALCVCAAHGAWEQGTVVPVRLDPTARSESETEPWRTLSAEESEKEAEMRVYRLDVFGMQLVLRLEPDQTFLAPGFVFHIVGTPVSEPTPKPNSGAEPGCFYSGTVNGDERSAAALNLCHGLRGGFYFKGEEYFIQPLNSTDFLGTDEDVHTIRRRGRAASAEESTSKCGVNEDEERVPKNLGKAASHGAPNADQTAHHRARRFVSTPRYLEIMLVADQSMAEFHGTGLKPYLLSIMAVASRLYRHPSIHNSISLAVVKLLVVYEEERGPQVSSNAAMTLRNFCKWQRQHNPPSDRHPEHYDTAVLFTRTDLCGAHSCDTLGMADVGTVCDPDRSCSIIEDDGLQAAFTVAHELGHVFNMPHDDAQLCSGINGAHWGSHMMASTLSNLDQQQPWSPCSALMVTTFLDNGHGQCLLDKPVKPEPLPQPLPGAVYDADHQCSLTFDEDSQHCPDLSTTCAALWCTVTTSNGLLVCQTKNFPWADGTPCGHDSYCLAGHCLTKSQAAKQQTPVNGGWGPWGPWGDCSRTCGGGVQYSFRACDNPVPENGGKYCEGKRIQYRSCNTEVCPDTNGLSFREEQCLAHNDMSAQVSLGSGDGVEWVPKYAGVSPKDRCKLVCRAKGTGYFFVLKSKVADGTPCSPDSTSVCVQGQCVKAGCDRIIGSNRRFDKCGVCGGDGSTCKKVSGSMERARPGYQDVVTIPAGATHLDIKQRAPASSRHDNSYLAVRRQDGTYLLNGDYKLMTMETDIPLPGALLRYSGSSATLERIRSFSPLPEALTIQVLSVGESPRPRVKYSYFAPRPNHAASSSNNNNIGGRRKSINAIQEVGGAEWTLREWGPCSQTCGEGVQQRAVVCLDSQGHPSGDCPEELRPLASRSCALHSCPSWLLGKWSPCSKTCGRGFRKRALRCIDHNGRTLTNDSCDPKDRPRPLLELCDQSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCY5</accession>
    <name>A0A3P9BCY5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neurofilament light chain</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCY5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007748"/>
    <dbReference type="Ensembl" id="ENSMZET00005008066.1">
        <property type="protein sequence ID" value="ENSMZEP00005007748.1"/>
        <property type="gene ID" value="ENSMZEG00005005562.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156208"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099160">
        <property type="term" value="C:postsynaptic intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099184">
        <property type="term" value="F:structural constituent of postsynaptic intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033693">
        <property type="term" value="P:neurofilament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050405">
        <property type="entry name" value="Intermediate_filament"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652">
        <property type="entry name" value="GLIAL FIBRILLARY ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45652:SF8">
        <property type="entry name" value="NEUROFILAMENT LIGHT POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="9">
        <location>
            <begin position="75"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="79"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="558" mass="63368" checksum="7E904032E5C03BF6" modified="2019-02-13" version="1">MASAGFDPYFSSAYKKRGVVRSGGYGTGGGGAARSVYSTHSAPVTSYASSRRSYPLRLDQAAQVSSEFKAVRTQEKAQLQDLNDRFASFIERVHELEQQNKLLETELLLLRQRQTEPSNIRALYEHEIRQLRVAVEEARHEKQAAQDHRDQMEDVLRNLQKQYEEEVLGREEAEGRLMDARKGADEATLGQAELEKRVETLLEELTFLKRLCESEIAELQAQIQYSAEVSVEMEVAKPDLSAALRDIRVQYEKLAQRNLQSAEEWFCNKMNVMTVGATRTTETARSAKDEVGEYRRLLKAKMLEIDACREMNQALENQLQEVEEKQSGEIAALQDTICELEEELRANKNDMARYLKDYQDLLNVKMALDIEIAAYRKLLEGEENRLNVAGPISVTGYSQAMFSAPSYGRTQISMHSQLSSAAPYLLSSRLYTTSLPTEETISASQAQQAEASPPEEEEEEQVEEEEKAEEEEKEEEEAEQEEGGEEEEEETAEKEGEEEEGEKEEEEEGGEDGQPEDEEDAEQKETEGDEEGEKEEETVKEEEAEAEEKNRKTTDKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD47</accession>
    <name>A0A3P9BD47_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">TNF receptor-associated factor</fullName>
            <ecNumber evidence="19">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TNF receptor-associated factor family. A subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="19"/>
    <dbReference type="RefSeq" id="XP_004549985.1">
        <property type="nucleotide sequence ID" value="XM_004549928.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD47"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007802"/>
    <dbReference type="Ensembl" id="ENSMZET00005008120.1">
        <property type="protein sequence ID" value="ENSMZEP00005007802.1"/>
        <property type="gene ID" value="ENSMZEG00005005940.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101472424"/>
    <dbReference type="GeneTree" id="ENSGT00940000156621"/>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD87</accession>
    <name>A0A3P9BD87_9CICH</name>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002060">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="156" mass="17490" checksum="C57455AF66B65C8C" modified="2019-02-13" version="1">MVDSKPVNLGLWDTAGQEDYDRLRPLSYSNSLSPCLSIQDVFLICFSLVSPASYENVRAKWYPEVRHHCPSTPIILVGTKLDLRDEKDTIEKLKDKKLAPITYPQGLALAKEIDAVKYLECSALTQRGLKTVFDEAIRAVLCPQPAKVKKKPCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDV1</accession>
    <name>A0A3P9BDV1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase D interacting substrate 220</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005007834"/>
    <dbReference type="Ensembl" id="ENSMZET00005008152.1">
        <property type="protein sequence ID" value="ENSMZEP00005007834.1"/>
        <property type="gene ID" value="ENSMZEG00005005897.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005008251.1">
        <property type="protein sequence ID" value="ENSMZEP00005007931.1"/>
        <property type="gene ID" value="ENSMZEG00005005897.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156714"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000030">
        <property type="entry name" value="Kinase D-interacting substrate of 220 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000195">
        <property type="entry name" value="Kinase D-interacting substrate of 220 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052771">
        <property type="entry name" value="Neurotrophin_sig_adaptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057092">
        <property type="entry name" value="SAM_KIDINS220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24116:SF1">
        <property type="entry name" value="KINASE D-INTERACTING SUBSTRATE OF 220 KDA ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23307">
        <property type="entry name" value="SAM_KIDINS220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="4">
        <location>
            <begin position="448"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Kinase D-interacting substrate of 220 kDa-like SAM" evidence="5">
        <location>
            <begin position="1202"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1334"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1411"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1610"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1486"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1539"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1628"/>
            <end position="1656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1713" mass="189040" checksum="F375A3C45B8BC811" modified="2019-02-13" version="1">MDTSTSLKMTSLAVQSLFSYVDEENLAAIKAHLDMFTDVDSRSDNGQTPLMVAAEQGSLEIVQELIKRGANVNLDDIDCWTALISAAKEGHIEVVRDLLENNANLEHRDMGGWTALMWAAYKGRTDVAQLLLEKGSNPNITGQYSVYPIIWAAGRGHAEIVRLLLEHGAKVNCSDKYGTTPLIWAARKGHYDCVMHLLANGADVDQEGANSMTALIVAVKGGYTEVVKELLKRNPNVNKTDKDHNTALTIAAKEGHTEIVQDLLDAGTYVNVPDRSGETMLIGAVRGGHVEIVRALLNKYADIDARGQDGKTALYWAVEKGNATMVRDILQCNPDTESATKEGETPLIKATKMRSIEIVELLLDKGAKVSSVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCTHQKSILTQIFGAKHLSPTESDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLVVFLTLLLCGSVAIVLGFTVNPKLAIAVSLSLLALLYIFFVLVYFGSRRERESWNWAWVISTRLARHVGYLELLLKLMFVNPRELPEQTTRALPVRFLFTDYNRLSSVGGETSMAEMIATLSDACEREFGFLATRLFRVFKSDEIQGQKWKKTCCVPSFVLFALTLGCLITGVALLSIFKVDPRNLTVNAVLIAMASMVGLALLLNCKTWWQVADSVLNSQRKRLHSAANNLHRLKSEGFMKVLKHEVELMSKMAKTIDGFTQNQTRMAVIIDGLDACEQDKVLQMLDTVRVLFSKGPFISIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGFNTAKKMSMAAPTNGEPLSGEGWHEDTDKKMSQSSLAQDQAKLGSKNALNRRDTYRRRQMQRTLTRQMSFDLTKLLVTEDWFCDISPQTMRRLLNIVSITGRLLRANHIIFNWDRLASWINLTEEWPYRTSWIILYLEEADGMSDQVTLKTIYERISKNIPTTKDVEPLLEIDGDIRSFEVFLSSRTPVLTARDVEMFLPCTVNLDPKLREIIADVRAAREQMHIGGVTYPTLPLQEAAARPQSVYTQHSAACSPAGSFTGSLPPQPHSAYFSGMTGPQHPFYNRPYFPHHVYHLPRHFSHHVPSSSRPSIKPPGQPQDTSGLDIIAEDASEAFHTSPIDPTMGSPAILLSSLNTDAVCERLRQLEGIDPTMLPQYTSTIKKANINGRVLTHCNLDELKKEMEMNFGDWQLFRGMVIEQRHAESQAALQDESRAASEQGSSVHLGEPSRRSGGAQRETAAFSLNLSFEELSGVGLEEPVRRSNNSHWPVANHRTSSMSSLNSQESSNDICKLTDKQQAEYHDAYREYIAQMAQLEMSGSGGERPVQPHPGQFLQAASSEDKGAKEGSDQDSRKSFTKRSSKNSDATDFASGTDGLDPISEEDEKLDHSSSSRTPGSKKKGAGSYYHKLPNDEDSGPEDSDNTTPLLHKEAKFGALSSHSSKPTGLLAKPGFLTEILIDKKDSSDSGMRSSESSSDPSLEEAEGETGRQRDALKPSLIELELEGLVKKRGPLPSSLSGLQDATVARMSICSEAPSEASLMASSPDEGWPSSGVSNLNHSASNTTLNNNTSSPSDTNTNTNNSHQQQATITGTESACSNIISPDVIIIPGSSTANTTAATIHHNQNLRTISLGDERESVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BE12</accession>
    <name>A0A3P9BE12_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_014268699.1">
        <property type="nucleotide sequence ID" value="XM_014413213.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BE12"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008122"/>
    <dbReference type="Ensembl" id="ENSMZET00005008447.1">
        <property type="protein sequence ID" value="ENSMZEP00005008122.1"/>
        <property type="gene ID" value="ENSMZEG00005006183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467173"/>
    <dbReference type="KEGG" id="mze:101467173"/>
    <dbReference type="CTD" id="6790"/>
    <dbReference type="GeneTree" id="ENSGT00940000154900"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="157"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="11">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="427" mass="48360" checksum="ACEDC75D258DFDA7" modified="2019-02-13" version="1">MDSTAMHKMPKGTKLQRPEIKSTSDGPKRIPVLQQSQPIQKAVVTPTPHQRVLGVSNGPQRVQRPMSHQKPVSNLPATVKSTHPADQNVNPATQNVNAATQLKPSTQQKQLKTQAPKPNLTKPQLEPQKPEKPQDKPAKNDHAQTSTSKTRWSLENFDIGRPLGKGKFGNVYLARERQTKFILALKVLFKKQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDASRVYLILEFAPRGELYSELQRCGHFPENISATYIMELADALNYCHTKKVIHRDIKPENLLLGANGELKIADFGWSVHTPSSRRSTLCGTLDYLPPEMIEGKTHDEKVDLWSLGVLCYEFLVGKPPFEAKTHEETYRRISRVEYSYPPQATISAGAKDLVARLLKHNPMHRLPIQGVLSHPWVVEYSTKKPTTLNSEEPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BE79</accession>
    <name>A0A3P9BE79_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase activating protein 23b</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BE79"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008209"/>
    <dbReference type="Ensembl" id="ENSMZET00005008536.1">
        <property type="protein sequence ID" value="ENSMZEP00005008209.1"/>
        <property type="gene ID" value="ENSMZEG00005006234.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157982"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01253">
        <property type="entry name" value="PH_ARHGAP21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000014">
        <property type="entry name" value="Rho GTPase activating protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23175:SF5">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="166"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="376"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="628" mass="71309" checksum="6EE55C13CBD6CE83" modified="2019-02-13" version="1">MELGEHREVISPVSVTQEVVLRQKLPPGRHTPIQTLQHSNYNTPVESTELPGLTLCTSPVPAETIPNRRSSGNLAQNVFDSLSSIPFIGSIKNRRSSYLLAITTERSRSCDEGLNTFREESPVFSKLPKRVKSFFTDGSLESLQAQEDARSKRHSTSELGIITFSDVHKEGWLHYKQILTEKGKKVGGSMRPWRRAFSVLRSHSLFLYKDKRDAVIHGAGAGPGQVEHCPISIRCCLIDIAYSETKRKHTLRLTTQDFCEYLLQAEDSDDMLAWIKVIRENSKTDNEEIGFSRQALINKKLNDYKKHSLTGSKLDSSPRAHRMMPPFFLAKTDNTSVNRASRSGGSKHDSDDNKALWSINIMKKAKKTGVPKAFGVRLEDCQPAVNHKFVPLIVEMCCGVVEATGLEYTGIYRVPGNNAMVSNLQEHLNKGMDLNTAEERWQDLNVISSLLKTFFRKLPEPLFTDDKYNHFIDANRIEDGEERLKTMNKLIHDLPDHYYHTLKFLLGHLKKVADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLILHVRTTNDNWDIQPLPNIDHLLTNIGKPGMPREASGEEWGLLQESFNASPTDRFNCTHIVKQLDSREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEC9</accession>
    <name>A0A3P9BEC9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Terminal nucleotidyltransferase 4A</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA polymerase sigma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Non-canonical poly(A) RNA polymerase PAPD7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAP-associated domain-containing protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">TRAMP-like complex polyadenylate polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Terminal guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004539755.1">
        <property type="nucleotide sequence ID" value="XM_004539698.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEC9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008126"/>
    <dbReference type="Ensembl" id="ENSMZET00005008451.1">
        <property type="protein sequence ID" value="ENSMZEP00005008126.1"/>
        <property type="gene ID" value="ENSMZEG00005006186.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480725"/>
    <dbReference type="KEGG" id="mze:101480725"/>
    <dbReference type="CTD" id="64282"/>
    <dbReference type="GeneTree" id="ENSGT00940000158301"/>
    <dbReference type="OrthoDB" id="8398848at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070568">
        <property type="term" value="F:guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060212">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905870">
        <property type="term" value="P:positive regulation of 3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF51">
        <property type="entry name" value="TERMINAL NUCLEOTIDYLTRANSFERASE 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="18">
        <location>
            <begin position="180"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="17">
        <location>
            <begin position="368"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="531"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="531"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="669" mass="74055" checksum="CFE6830AF8348556" modified="2019-02-13" version="1">MDPRIAWFQPEQRGPANNLWMQIWEMTQRIGYLYVNNSYTTVSSPKANVNGVSGAVVAEGNEAPDTKSSGIGEAKTQGMSAPMGDGELTVQGDFIPLETNSNHNSRVVGTGGVGGGGQQQHGSGVAVSGVTDGQPPKRKRDNKASTFGFSVILNGDNKEYVGYTGTPWKERNYSEGIIGLHEEIIDFYNYISPRPEEEKMRLEVVDRIKEVIHDLWPSAEVEVFGSFSTGLYLPTSDIDLVVFGKWESLPLWTLEEALRKKNVADENSIKVLDKATVPIIKLTDSYTEVKVDISFNVTSGVKAARLIKEFKEKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHYREDVFGLNINIGVLLIEFFELYGRNFNYLKTGIRIKDGGCYVAKDEVQKNMLDGYRPSMLYIEDPLQPDNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKFYPNNESESILGRIIRVTQEVDDYREWIRKKWGSPLNKNEVTLFESQQLDERNNNVPDDDNDPVVAVLSTPLSKTSSNSSSPSLRSSPSSSPLSPSSTSSTSTSSDGDSDSTPCKTAKQQPSRGSSAHREKSAAVSNHRTQSHTTSTPPGGNKGGKARMSRSHQKSGHHGQQTNFSGGKSHPSNKPHHHQASSKRRKNVRDSTQEDLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEE5</accession>
    <name>A0A3P9BEE5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004566915.1">
        <property type="nucleotide sequence ID" value="XM_004566858.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEE5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008275"/>
    <dbReference type="Ensembl" id="ENSMZET00005008604.1">
        <property type="protein sequence ID" value="ENSMZEP00005008275.1"/>
        <property type="gene ID" value="ENSMZEG00005006300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479016"/>
    <dbReference type="KEGG" id="mze:101479016"/>
    <dbReference type="CTD" id="6902"/>
    <dbReference type="GeneTree" id="ENSGT00390000009710"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000008">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="108" mass="12569" checksum="B8E0E289C3C1CB32" modified="2019-02-13" version="1">MADPRTRQIKIKTGIVKRLAKEEIAYITEAKQQEEKIERLKTEAADDYVIKKQMEVLQESRMMIPDCHRRLAIAHADLLQLLETEEELAESEEYKEARSILDSVKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEP7</accession>
    <name>A0A3P9BEP7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEP7"/>
    <dbReference type="Ensembl" id="ENSMZET00005008712.1">
        <property type="protein sequence ID" value="ENSMZEP00005008379.1"/>
        <property type="gene ID" value="ENSMZEG00005006387.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175874"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER K-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="74"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="198" mass="22694" checksum="091BF9AD263E12AD" modified="2019-02-13" version="1">MSVFICQVGYQTPPLWGHLRPPNLGGPISTHHHFPCRWRTPSGVGALVVLCVWGWAFHNKTFSFLSGGLSTLPPHSREYHFVNQLMTWTEAQSYCREHFTDFVTIYNSNINQLLFSMSPRINAFAWKGLYDDPYSWKSSMEGKLFYVGSTHEFLIWANGQPNNENTNEYCVALQGQTQMNDRPCGSSYPFLCYNEFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFX0</accession>
    <name>A0A3P9BFX0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal pentraxin receptor b</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BFX0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008810"/>
    <dbReference type="Ensembl" id="ENSMZET00005009150.1">
        <property type="protein sequence ID" value="ENSMZEP00005008810.1"/>
        <property type="gene ID" value="ENSMZEG00005006689.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000248591"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000012">
        <property type="entry name" value="neuronal pentraxin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF162">
        <property type="entry name" value="NEURONAL PENTRAXIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51828">
        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pentraxin (PTX)" evidence="8">
        <location>
            <begin position="384"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="414"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="597" mass="63787" checksum="5E1CCE1706F2E11D" modified="2019-02-13" version="1">MKFAVVLVGAGTLAFLGAVICIIASVYPFKRAALVSDNGTLTSESLLQPLEPGSVAHAGPLGALHGAESYDGGNGLGGIGVEVPTLNELNLGEETGGGPAKQFSFSRLICTPVPVGECKTKDLRQRRDHQQQQADDPLYGTGDEDLRTTAEELRQMVLQQNDQILMDQRTIRELTGKLSECESGLEDERSIPERSIGVWSGNRRVMAGDDVTSSAAAQLQTARAVEELARAIMELKDRIEKLEAEIGPAALNLTDTSVGVNSGGSSSGSGSSTAGNTGKAPAPPSSTTSSLSAGSAPGGRRPASPGSSASRPPAKGPPGRGKSTWRVEDLEGELERKIKMLEKERQAMRKETQGQHEKINKGIDNVSHRVTELEHTMTEPPFPDGFVISFPMRTNYMYGLVRKEITEMYAFTACLWLKAKEGGIGTPFSYSVPGQPNELVLLQGVHNPVELLINDKVAQLPLSLPQDEWQHICVSWTLRDGVWKAYQGGKMKGRGEGLAAWHPIKPGGVLILGQEQDTLGGRFDASQALVGELSQFNLWDRVLKPAEVAAVADCSSSALGNIAPWTDHDVDVYGGATKESLDPCHAAQRSNPSGPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGI2</accession>
    <name>A0A3P9BGI2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Unique cartilage matrix-associated protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UCMA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567834.1">
        <property type="nucleotide sequence ID" value="XM_004567777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGI2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009020"/>
    <dbReference type="Ensembl" id="ENSMZET00005009368.1">
        <property type="protein sequence ID" value="ENSMZEP00005009020.1"/>
        <property type="gene ID" value="ENSMZEG00005006830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475800"/>
    <dbReference type="KEGG" id="mze:101475800"/>
    <dbReference type="CTD" id="405870"/>
    <dbReference type="GeneTree" id="ENSGT00390000011492"/>
    <dbReference type="OrthoDB" id="8907123at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045667">
        <property type="term" value="P:regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031386">
        <property type="entry name" value="UCMA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28647">
        <property type="entry name" value="UNIQUE CARTILAGE MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28647:SF2">
        <property type="entry name" value="UNIQUE CARTILAGE MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17085">
        <property type="entry name" value="UCMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0765">Sulfation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018305952" description="Unique cartilage matrix-associated protein" evidence="11">
        <location>
            <begin position="27"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="137" mass="16121" checksum="EB7339C24CED921B" modified="2019-02-13" version="1">MSWTYATLLALLTVLFALSWSPEASSAAVPSSTGSTKDPQGPLKRVFMKQADASNFFRRRSRRGVKSQDELDAEQRQILAADERKREFHEEKRNEFESYAEEEHDEQNERSRESTEQWREFHYDGMHPAYEYNRHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BID4</accession>
    <name>A0A3P9BID4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G protein-coupled receptor 157</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004554283.2">
        <property type="nucleotide sequence ID" value="XM_004554226.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BID4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009694"/>
    <dbReference type="Ensembl" id="ENSMZET00005010054.1">
        <property type="protein sequence ID" value="ENSMZEP00005009694.1"/>
        <property type="gene ID" value="ENSMZEG00005007340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475858"/>
    <dbReference type="KEGG" id="mze:101475858"/>
    <dbReference type="CTD" id="80045"/>
    <dbReference type="GeneTree" id="ENSGT00390000012992"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
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            <begin position="50"/>
            <end position="73"/>
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            <begin position="120"/>
            <end position="142"/>
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            <begin position="168"/>
            <end position="192"/>
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            <begin position="227"/>
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        <location>
            <begin position="308"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="332" mass="37287" checksum="38C9D4855D394A95" modified="2019-02-13" version="1">MANATQTQTEVYLFEQVIVLFSCALSFLGSSLIILTYIIWSDLRTTPRKLLVYLSVSDWLSAVSYAFGVWSVFRTNSAECVAQGAISTFANTSSFFWTVAIAVYLYVFIVRANQRVADSLVLVFHLVSWGIPLAITIAAVSLNKIGYDASEVSVGWCWVRINVQDRVLWMLLTGKIWEFLAYLTLPFLYILIKRHIHIAHAALSEYRPILANRPPAHSFSSMADVKLTLIPIIFIVLRIWSTVRFILLLADSSVRQNPALVTLHGIGNTLQGAANCVMFVLFTQPIRTRLCAALTSCSQCRAEAQRPHRLLPEQDATARREEDSTERGHADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIJ5</accession>
    <name>A0A3P9BIJ5_9CICH</name>
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        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005009750"/>
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        <property type="protein sequence ID" value="ENSMZEP00005009750.1"/>
        <property type="gene ID" value="ENSMZEG00005007384.1"/>
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        <property type="component" value="LG18"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
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    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
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    </feature>
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            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
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        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="203" mass="22454" checksum="C740FECDE1972A43" modified="2019-02-13" version="1">MERQHSNNLLNFLNEDRSRQKFCDVFVSVGGKTYSAHKVVLAHGSSYFHAELSKNPSAKTHVTLEHVEDSVFQHLLSFLYTAECVVAETALPLLCKDGEVQPVSVIQTQVETIASHKVETTSNNSPGADTEINSPADVQGNLFGHDNSNQGQLAESVHTDVHQEASNEEEKTTGQGSATTRRSARRRRTPTKYKRNDGEYISV</sequence>
</entry>
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    <accession>A0A3P9BIP2</accession>
    <name>A0A3P9BIP2_9CICH</name>
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        <recommendedName>
            <fullName evidence="1">AP-5 complex subunit beta-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Adaptor-related protein complex 5 beta subunit</fullName>
        </alternativeName>
    </protein>
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        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004559936.2">
        <property type="nucleotide sequence ID" value="XM_004559879.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIP2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009757"/>
    <dbReference type="Ensembl" id="ENSMZET00005010117.1">
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        <property type="gene ID" value="ENSMZEG00005007391.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101464724"/>
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    <dbReference type="GeneTree" id="ENSGT00530000064721"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030119">
        <property type="term" value="C:AP-type membrane coat adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038741">
        <property type="entry name" value="AP5B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048980">
        <property type="entry name" value="AP5B1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048981">
        <property type="entry name" value="AP5B1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048979">
        <property type="entry name" value="AP5B1_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048978">
        <property type="entry name" value="AP5B1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34033">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34033:SF1">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21589">
        <property type="entry name" value="AP5B1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21590">
        <property type="entry name" value="AP5B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21588">
        <property type="entry name" value="AP5B1_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21587">
        <property type="entry name" value="AP5B1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-5 complex subunit beta-1 N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="AP5B1 middle" evidence="6">
        <location>
            <begin position="254"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit beta-1 beta-barrel" evidence="7">
        <location>
            <begin position="743"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="AP5B1 C-terminal" evidence="8">
        <location>
            <begin position="838"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="937" mass="103998" checksum="C873C2262F3F532F" modified="2019-02-13" version="1">MAANWAERISAFSRRPSGFLSGTTAEAFLAELLRELRDDRATYSVKILLLSPLCEHPTLLCCSDSVGEETALELMSVFAQCPPKSVQFRCHLLLALTSVLICTSCVKSHSRASLDFLDVLLQIAQDTSDIHTDGSQRPLRAIACECLRELEACCPGLLSQRLELLGGLWQQETSRLHQAYAELYTLVLRNAIYQLTQETGAGAEHLKALLGGNTSAAWEADQESGLASSKDSAILSSLILGPMGTVPTLHTGPDCKELRSVLSTLLDESYLLTPLCQATLLHRLTEVVAMVPGVPPAIFRTHLLRLLGTSEVSLLHATLLLKCAFTDSLFSSEDEAFILKRLVVLSQHLLLSTPEKLFYMDCILHFPENRPISCGDGDETLPVLLTPQLASALVPTVFNDSATLLARFNMLSLVYLEEGEEGQGGQGLAYLYEHLSSLLSMVENGCGRELVVTFFRAAFLFLYYFCHVERYSNDLTKQLCQLYLNHTKLAPHFINLADQTQDRLSESSWSVGLLKALQRVITEAPLTQLTSHDLSRHLKMLARVAEEGEIIQQSTLTFLSSIITPSSSSLCTGGDWRLGNEILRVCRHLLVHPSLDSLLTPLADVLQLLVCHYADMEIQDHARLYYTLLTTLSREKLAGVLAQGMEEGGRQDKKQSLSCLIGEGLTSTLTIQQTERAVFRLIEAPPEPRAGDINSNEVQKGPEEASASMEAYRDQFSDSSFASEITLQYQLVHINSHDSHFDQLFSIRLHFSLTDHHYEELGDISVPCLLRERPSAIVQLTLKPRKPYPTSLHASAIFTSPDGHTWHTTLPDIHVAFQQTFLPLPVPSNWGRGGTLSVFEGLWDEICSESGDSAMSLFCCQLKEAALNTLVEKHFLPFLISDASHKEEFKVLFFLPPRSHILLKVSSEEDAVHFNIATDNWELLSHVNSYLLKITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIS0</accession>
    <name>A0A3P9BIS0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger E-box-binding homeobox 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIS0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009606"/>
    <dbReference type="Ensembl" id="ENSMZET00005009965.1">
        <property type="protein sequence ID" value="ENSMZEP00005009606.1"/>
        <property type="gene ID" value="ENSMZEG00005007280.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000168625"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000013">
        <property type="entry name" value="Putative zinc finger E-box-binding homeobox 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000082">
        <property type="entry name" value="Putative zinc finger E-box-binding homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF28">
        <property type="entry name" value="ZINC FINGER E-BOX-BINDING HOMEOBOX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="667"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="427"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="694"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="729"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="801"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="847" mass="93585" checksum="1CF6491A22AEB531" modified="2019-02-13" version="1">MVCPLCGYTATLRLEMERHLALHNPVQDKSAMTLDQGMETRKFKCLQCGKAFKYKHHLKEHLRIHSGEKPYECSNCKKRFSHSGSYSSHLSSKKCLSGGGHGGGNPGGASGVFNGHSQSSYPHSFPTSPSAGGGRSSNEKGSVLVLQNQDNTRPLGQVPVDPLQLSLQDLNQNTASLSSASDLARIWDPSELSLRASMLKGTSLLPYLHSGGTKFEHMLQEMFQRDVKKDEDLVREGGDEEERRAHQNGGSHERKVSPDRRRDTLSVEPERGVLGIMCRWCSQHFSSVAALLHHERHLCQLNREAAEVPEGFRSKAPSSPSIFFPRSVLQPENSKLSVVTNGLSGNKSPSQKHNWHAVPQHLLVAMHSPPQLHHNALSSRLHWPSQEKGSPSELTHRSPELSSPRGRKRALSSGFTSPVCLDLTSCSPELSSPQKETSNPWSAQNEPLDLSLPKQLSDQSSRNKTVNGSSGRGERRELGTQQLGRPSPTSHLPLHSHPVFSVAGAPVFPGSLYNGFPMFSQAGVGLSGHEGITSIPFNQTANTPGFLSPLAYMMEADAEATLKKIYQERQGLMGEALNRGALDYLSLIDEGFDGEGGPGRKRLKKTDEGLYACDICEKTFQKSSSLLRHKYEHTGKRPHECKICNKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYAYCSKDQDPDQDQDDMPLTPGAGNSLVGRLSEDAPLSLDETQTPHSFLSDSSLDGAPDALKEEEEEEEEGEERVCDDRKEGADVNLPDPAEELGGNPIQESPAGENGVQSERNRYDMQDHIDNTESQTWDRDTEDRNGDLDKCELSLDLTELPRIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJQ2</accession>
    <name>A0A3P9BJQ2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium inwardly rectifying channel subfamily J member 13</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570914.1">
        <property type="nucleotide sequence ID" value="XM_004570857.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJQ2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010184"/>
    <dbReference type="Ensembl" id="ENSMZET00005010553.1">
        <property type="protein sequence ID" value="ENSMZEP00005010184.1"/>
        <property type="gene ID" value="ENSMZEG00005007696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482683"/>
    <dbReference type="KEGG" id="mze:101482683"/>
    <dbReference type="GeneTree" id="ENSGT01140000282491"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000081">
        <property type="entry name" value="inward rectifier potassium channel 13 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF3">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="51"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="189"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="362" mass="39998" checksum="12940177C9C74B2B" modified="2019-02-13" version="1">MTSKSKGSVPGDKASSSLLLSSPPYQRLITKEGRCAFRVPLSSSGSRRESLHRAWLLALQDLWGLLVNLRWRWTLLAFCSSFVAHWLFFACLWYLLAHLNGDLDVQDHDAPPQGHVVCVKYITSFSAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAVQMLLGLMLEVFITGAFVAKLSRPQKQAGAIQFSPQAVVGQHLGQTCLMVRATNLLKRPLVDVKLSAVLYKCEGQALHQTSLDFYLDHLGQKACPLFIFPLTFYHPLEPQSPLYPALCEGSSTNFELVVFLSALQEGTGDSCQKRTSYLRQEIKLNHCFAPAFRIDSRGRYTVSSQHLSTAPSNEPVNKDSVVQINSDGMEQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BKP3</accession>
    <name>A0A3P9BKP3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">IgLON family member 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the immunoglobulin superfamily. IgLON family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551095.1">
        <property type="nucleotide sequence ID" value="XM_004551038.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BKP3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010503"/>
    <dbReference type="Ensembl" id="ENSMZET00005010875.1">
        <property type="protein sequence ID" value="ENSMZEP00005010503.1"/>
        <property type="gene ID" value="ENSMZEG00005007916.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468483"/>
    <dbReference type="KEGG" id="mze:101468483"/>
    <dbReference type="CTD" id="402665"/>
    <dbReference type="GeneTree" id="ENSGT00940000160467"/>
    <dbReference type="OrthoDB" id="6159398at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000013">
        <property type="entry name" value="cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000305">
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    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
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        <source>
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        <source>
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    <sequence length="333" mass="37149" checksum="654C48AA52120A3A" modified="2019-02-13" version="1">MGCPLLRNVFAALILVLLSKGSSVHGAEFGHLPDNITVLEGESVTLRCRIDEEVTHKAWLNRSNILFTGTDKWSLDRRVTLVNSNNSDFSIHIDKVQVTDEGPYTCTFQANNKPRIVHVYLIVQVPARIVNISKNVSVNEGENVNLYCLAVGRPEPTVTWKEQKYGTLREGEFLEITEITRQQAQDYECITNNGVAPPDQRKVIVTVNYPPMITDMKNMPAHLGKTAILRCEAMAVPPASFEWYRDDHRPVESDNTLRIKNEKTRSLLLFTNVTEKHFGNYTCFASNRLGASNASMLLFRPGALQGRGTGLHAGISVIVCVWVSLSAALLLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLF0</accession>
    <name>A0A3P9BLF0_9CICH</name>
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        <submittedName>
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        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="nucleotide sequence ID" value="XM_004557362.1"/>
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        <property type="gene ID" value="ENSMZEG00005007901.1"/>
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        <property type="term" value="C:dendritic shaft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="term" value="C:neuronal cell body"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of protein kinase C signaling"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Complement Module, domain 1"/>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
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        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SEIZURE PROTEIN 6 HOMOLOG"/>
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        </source>
    </evidence>
    <sequence length="1021" mass="112038" checksum="AA78A4AEA33C6F70" modified="2019-02-13" version="1">MCVKQGCQFQTLCTVLLLAAAVAEIHGQVAKDSNSISKRTLDLDRDLFTHSSTQDTESEVHSITTVSPMNIPNHQPVFKGLLLHEHLLTRDFRGDQHFFRKDGYVAAYPTMPGSVSAPNAADLVTQLVPHEDAPAFSDVASTATVAATSPLTTFSPTTPALPMSMPQKKSKERTRGTDKVDPTTHSLTTQVTPNNRGSGGENSGVPPSSSLGSQPQSLGASPEEATSGKMEKGEASEMALKNKTSPGHQLHKLTPASSEKDTTTMSTTVTTTTTITTMQTSEPCSLNFTDPEGNIEILQQLDSGVECNYLITVYLGYGIEVQVLNVSVLEGEQVTVEDTGGQEPFILANESVLMTGLVLRSWSNQISISLRSEKRRNSAYLLLHYQAFVLSCAFPKEPAGGEVSVTHLHPGGEAYFNCFTGYKLQGPKMLTCRNATTPYWSGKEPRCVASCGGMIKNATYGRIVSPGFPGNYSNNLTCHWVLEAPEAHRLHVHFEKVALAEDDDRLLIKNGNNIDSPPVYDSYEVEYLPNEGVLSTGRYLFVEFTTDGTMTSTGAAIRYEAFAKGMCYEPFVKYGNFSSSDSTYSVGAVVEFSCDPGYTLEQGSVVIECVDAQNPQWNETEPACRAVCSGEITDSAGVVLSPNWPEAYDKGQDCIWGIHVEEDKRIMLDIQVLHLGKNDLLTFYDGDDLTANILGQYSGTRPHFKLYTSMADVTIQFQSDPATNIYGYNNGFVVHFFEVPRNDTCSELPEITNGWKSMSHPDLIHGTVVTYQCYPGYTLVGSEILMCQWDLSWSGDVPKCEEVMTCQDPGNVQHSRKVITGSRFAVGSTVQFICNKGYILSGSSLLTCYNRDSAMPKWNERLPKCVPEKYEPCRNPGAASTSMQSSEKAFYQAGEMLTFSCHPGYELQGYATIYCVPGHPSQWNSTPPACRASSTHYVNERRLDVVNTNYGTEGTNIALAVFIPTAVILVIVLGIYIYFAKLQGKSIRMPMSSPPYDNMTEESAFDNPIYESGHWQTHSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BN08</accession>
    <name>A0A3P9BN08_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Solute carrier family 25 member 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>citrate(out) + (S)-malate(in) = citrate(in) + (S)-malate(out)</text>
            <dbReference type="Rhea" id="RHEA:72483"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-threo-isocitrate(in) + citrate(out) = D-threo-isocitrate(out) + citrate(in)</text>
            <dbReference type="Rhea" id="RHEA:72471"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)</text>
            <dbReference type="Rhea" id="RHEA:72475"/>
            <dbReference type="ChEBI" id="CHEBI:16383"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate(out) + succinate(in) = citrate(in) + succinate(out)</text>
            <dbReference type="Rhea" id="RHEA:28835"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>maleate(in) + citrate(out) = maleate(out) + citrate(in)</text>
            <dbReference type="Rhea" id="RHEA:72491"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)</text>
            <dbReference type="Rhea" id="RHEA:72487"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>trans-aconitate(in) + citrate(out) = trans-aconitate(out) + citrate(in)</text>
            <dbReference type="Rhea" id="RHEA:72479"/>
            <dbReference type="ChEBI" id="CHEBI:15708"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567017.1">
        <property type="nucleotide sequence ID" value="XM_004566960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BN08"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011317"/>
    <dbReference type="Ensembl" id="ENSMZET00005011711.1">
        <property type="protein sequence ID" value="ENSMZEP00005011317.1"/>
        <property type="gene ID" value="ENSMZEG00005008502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480153"/>
    <dbReference type="KEGG" id="mze:101480153"/>
    <dbReference type="GeneTree" id="ENSGT00550000074856"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF6">
        <property type="entry name" value="SI:DKEY-178E17.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="128"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="19">
        <location>
            <begin position="224"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="317" mass="34446" checksum="061082479A84A548" modified="2019-02-13" version="1">MSGQNTFVSPFHRPQCLAAAAPAGKAKLTHPGKAILAGGIAGGIEICITFPTEYVKTQLQLDEKANPPKYKGIVDCVKQTVKGHGVRGLYRGLSSLVYGSIPKAAVRFGMFEFLGNKMRDESGKLDSKQGFFCGLGAGVAEAVVVVCPMETIKVKFIHDQTSANPKYRGFFHGVREIIRSQGLKGTYQGLTATVLKQGSNQAIRFYVMTSLRNWYKGDDPNKAINPLITGLFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYKSTVDCAVKILKHEGPLAFYKGTVPRLGRVCMDVAIVFIIYEEVVKLLNLVWKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNK2</accession>
    <name>A0A3P9BNK2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Frizzled class receptor 10</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNK2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011520"/>
    <dbReference type="Ensembl" id="ENSMZET00005011920.1">
        <property type="protein sequence ID" value="ENSMZEP00005011520.1"/>
        <property type="gene ID" value="ENSMZEG00005008644.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161861"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090504">
        <property type="term" value="P:epiboly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000007">
        <property type="entry name" value="Frizzled class receptor 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000020">
        <property type="entry name" value="Frizzled class receptor 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF86">
        <property type="entry name" value="FRIZZLED-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018336046" evidence="18">
        <location>
            <begin position="22"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="19">
        <location>
            <begin position="30"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="20">
        <location>
            <begin position="227"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="146"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="554"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="580" mass="65585" checksum="20ACA69708D871B4" modified="2019-02-13" version="1">KLDVLLPLSLCVLAFLHEGSAISSIDPDWSGEGRCQHITIPQCKDIGYNMTRMPNLMGHDDQKEAAIKLQEFATLIQFGCHSHLRFFLCSLYAPMCTEQVSNPIPACRVMCEQVKLKCSPILEHFNFHWPESLDCSRLPTKNDPNNLCMEAPNNGSDEPPKVSHTQPPDFRLQRPLSGQDLHPKDSGSKQMCSNPGKFHFVEKSESCAPKCYPKVDVYWSQGDKQFSLVWMAIWSILCFVSSAFTVLTFLIDPQRFKYPERPIIFLSMSYCVYSVGYLIRLFVGADRIACDRDNGVQYIIQEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAIKTIMILVMRKVAGDELTGVCYVGSMDVKALTGFVLIPLSCYLIIGTSFLLSGFVALFHIRKIMKTEGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWRILAGEQKCSSSGLESDDCIMKASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVFSRKIKKRTRRKAASVFTSSRPYIKPHPSLKGPNTKYEPTRPPPTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNQ4</accession>
    <name>A0A3P9BNQ4_9CICH</name>
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        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain 34Ba</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKRD34 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567027.1">
        <property type="nucleotide sequence ID" value="XM_004566970.2"/>
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    <dbReference type="Ensembl" id="ENSMZET00005011958.1">
        <property type="protein sequence ID" value="ENSMZEP00005011557.1"/>
        <property type="gene ID" value="ENSMZEG00005008675.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482578"/>
    <dbReference type="KEGG" id="mze:101482578"/>
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    <dbReference type="GeneTree" id="ENSGT00390000012355"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
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        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042637">
        <property type="entry name" value="AN34A/B/C"/>
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    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156:SF1">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 34B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="532" mass="57924" checksum="8173A9EDC277B5B5" modified="2019-02-13" version="1">MEAEGCNPGVTIDSGNPLLKAVFLRRLRLTRLLLEGGAYINESDSQGQTPLMVACRTQHVDAQSASRVKLIQFLLEKGADPNIQDKEGRSALMHACREQAGPEVVSLLLASGADISLEDQSGTSALVYAVMTGDLKVLNLLLDACKDKGKEVIIITTDKFPCGKLQTKQYLSMPPLRPLDQAEKMTLPAPASPSEIQLITSPQCTSSTLCPPKPVFSFKEAQICGISSHPCSPSRFRGLCQAPLNGLQQPLLRLNSEPWLKIPASLLTQQPLEASVSEKAQDLSRTDNFSFRVPRLDEDNSQNSDSYKWCEASNEKARDGKNDSAKQVGQKIPLPGLISSHSASHPNLHSENLGTDSVPSSLSTGKILVTQLQPCMASSSLHNVIQRRKLGADIYNSDPQIAVNIQNVPEEQKARDLTDGKRLAPLHSSSTMGSRELVSGTSQRILSGYERRGSGAFLLDLNSQARPRSLPPLTNTPILNVCNLSNGSSFSEKESGQKQFFPSAPPGPRKELTRRMLLRRHSMQTEQFKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRV6</accession>
    <name>A0A3P9BRV6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004539620.1">
        <property type="nucleotide sequence ID" value="XM_004539563.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRV6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012356"/>
    <dbReference type="Ensembl" id="ENSMZET00005012789.1">
        <property type="protein sequence ID" value="ENSMZEP00005012356.1"/>
        <property type="gene ID" value="ENSMZEG00005009292.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469683"/>
    <dbReference type="KEGG" id="mze:101469683"/>
    <dbReference type="CTD" id="55794"/>
    <dbReference type="GeneTree" id="ENSGT00940000161738"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="179"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="400"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="561" mass="61848" checksum="4A0B1C39507B0AFD" modified="2019-02-13" version="1">MQAVKVAHLALVASRALGSRRLCCCELFKASAWLRSLGQSRFCQTGAETAVIRVPRYLQRRIENVKEIRSKSKINTIKAGKLLIQSKNPALNQSAGYILGKFEQPSLCSKGWKHNKSFGDYFSINNVRAVAPYVAENGNEDAEQKPLATFNNLHICKELVETLETLSIKHPTTVQLQTIPKVMRGHNVLCAAETGSGKTLSYLLPVIHRLQADRESESYSESAHKICTVVLVPSRELAEQVAAVSRTLCAPFGFVTRTIGGGRGVGHIKTVFRRDHPDILVATPGALVKALRRRCLDLSELGFFVVDEADTMFDPSFSDMLENILLHVNVASDPKETRGLGHKAQLLVVGATFPGGVGDVLSKVTDLGKIVIIRSKMLHFLMPHVKQTFLKVKGADKILELHQALKLLQQDRGGGAVLVFCNKSSTVNWVGYSLEEMGVKHARLQGEMPAAVRAGIFHSFQKGNVDVLICTDIASRGLDTSRVRLVVNYDFPESHTDYIHRAGRVGRAGGVEDGEVLSFVTHPWDVELVQKIETAARRRLSLPGMESDIHEPKPIMLNEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTP5</accession>
    <name>A0A3P9BTP5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Si:ch211-172l8.4</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTP5"/>
    <dbReference type="Ensembl" id="ENSMZET00005013721.1">
        <property type="protein sequence ID" value="ENSMZEP00005013269.1"/>
        <property type="gene ID" value="ENSMZEG00005009974.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176901"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="74" mass="8228" checksum="6D8A294407ED318D" modified="2019-02-13" version="1">FVSCYASVQPLQLFGRGPRGGNYLSLLTNRGPRCAPRPRLACHAPKMTLRQICRMLKVMKQIRNREAAATASPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BU10</accession>
    <name>A0A3P9BU10_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nfe2 like bZIP transcription factor 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. CNC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547917.1">
        <property type="nucleotide sequence ID" value="XM_004547860.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BU10"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013397"/>
    <dbReference type="Ensembl" id="ENSMZET00005013851.1">
        <property type="protein sequence ID" value="ENSMZEP00005013397.1"/>
        <property type="gene ID" value="ENSMZEG00005010077.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471350"/>
    <dbReference type="KEGG" id="mze:101471350"/>
    <dbReference type="CTD" id="9603"/>
    <dbReference type="GeneTree" id="ENSGT00950000182892"/>
    <dbReference type="OrthoDB" id="7458135at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14720">
        <property type="entry name" value="bZIP_NFE2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.880.10:FF:000004">
        <property type="entry name" value="Nuclear factor, erythroid 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF8">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="526"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="646" mass="70593" checksum="EDE519A59B3D1F2F" modified="2019-02-13" version="1">MQIAKKYFSESLIQLTILLSLIGVRVDIDSYLSGYYTPLTEINLGPSSAYIQTPFHILRDTFDGYGVHPKCPELDYFFASRRLLDEVRTLGSPRFHTQLNAWLVHEVPATDKADCGPSTSNNTESSSGLESPGEESRDVSEHLPVSGPAVYQTNIELGQGPCGAGACGFLKEEEDVKVKEEEEPAPVSQLAHSSTLEQESLLEGITALSSPTRHPSATLDIDQQWNNLLSVADLDDLDPLVTERLSDLDTDITSAISRNVSLHDAMLTSPGVFGLASDRTEPRTTTQQQRALFRMESIGSLNSDASPGMALGLAALPFASVCNITGNVSSNSALGGCLDEAVFDQINQLGLEGLDSIDSSLMDCLDSIDPRVLEDLESDSGLSLESSSGGPVSPGSSEMSSSSSSYCEDECGATGYSSEADSIPSKGIVDYTTAWPPVESVWHDHSYSSANFFNQPSVTLPRKNIKEEPLSDDDGFRLEEGELSRDELRARAMCLPFSVLQIVNMPVEEFLEVLDGHGFSPEQVTLLRDIRRRGKNKLAAQNCRKRKLDAITGLQEEVERLQVQRDKLLREKHLTAKTMGAVGHQIRQLTRDILSRLRDESGTPLNPDRFTLQCGANGRVVVQPVRRPAVSTSGNKTDKRKKEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVI4</accession>
    <name>A0A3P9BVI4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Runt-related transcription factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with DDX5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004542248.1">
        <property type="nucleotide sequence ID" value="XM_004542191.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012771709.1">
        <property type="nucleotide sequence ID" value="XM_012916255.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVI4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013927"/>
    <dbReference type="Ensembl" id="ENSMZET00005014398.1">
        <property type="protein sequence ID" value="ENSMZEP00005013927.1"/>
        <property type="gene ID" value="ENSMZEG00005010495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474902"/>
    <dbReference type="KEGG" id="mze:101474902"/>
    <dbReference type="CTD" id="405788"/>
    <dbReference type="GeneTree" id="ENSGT00940000166083"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007178">
        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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            <end position="195"/>
        </location>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWB3</accession>
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            <taxon>Cichlomorphae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="8">HTH CENPB-type domain-containing protein</fullName>
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        <name type="scientific">Maylandia zebra</name>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00674">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="8">
        <location>
            <begin position="234"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="598" mass="68424" checksum="2B8515B201A95697" modified="2019-02-13" version="1">MSGKHFKAHEVSCCIKYFIFGFNIIFWFLGVAFLAIGLWAWSEKGVLSNISSITDLGFVCLLKFSVFLGIIFFLELTAGVLAFVFKDWIKDQLNFFINNNIRAYRDDIDLQNLIDFTQEYWECCGAFGADDWNLNIYFNCTDSNPSREKCGVPFSCCTKDPAVCMCIMQDIVVLTTLKMAKRHAYEAQFKLKAISYAEEHGNRAVAREFKINESMVRKWRKLENKLRQVKKTQLSFRGHKARWPELEERLERWIIEQRASGRSVSTVTIRLKAVSLAEEMNIEHFQGGPSWCFRFMKRCHFSIRTRTTIAQQLPADYKEKLAIFRSYCSKHIGDKNIQPSHITNMDEVPLTFDIPVSHTVEKKGTSTVAIRTTGYEKSSFTVVLGCHANGQKLPPMVIFKRKTLPKEKFPAEIIIKANEKGWMDEEMMKEWLREVYVRRPGGFFHASPSLLICDSMRAHLTADVKKLVKQMNCELAVIPGGLTKELQPLDIGVNRPFKVRLRAAWERWMTGGDHSFTKSGRQRRASYATICQWIVDAWANMSAGTVVRAFAKAGIISEEPHGTESDSDGEDSEPGMFDGDLAQLFNSDTEDEDFDGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXL9</accession>
    <name>A0A3P9BXL9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ras-related protein Rab-4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cell membrane</location>
            <topology evidence="17">Lipid-anchor</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539536.1">
        <property type="nucleotide sequence ID" value="XM_004539479.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXL9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014738"/>
    <dbReference type="Ensembl" id="ENSMZET00005015223.1">
        <property type="protein sequence ID" value="ENSMZEP00005014738.1"/>
        <property type="gene ID" value="ENSMZEG00005011086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471216"/>
    <dbReference type="KEGG" id="mze:101471216"/>
    <dbReference type="CTD" id="5867"/>
    <dbReference type="GeneTree" id="ENSGT00940000157464"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001944">
        <property type="term" value="P:vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04113">
        <property type="entry name" value="Rab4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000280">
        <property type="entry name" value="Putative ras-related protein Rab-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041819">
        <property type="entry name" value="Rab4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 17" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="213" mass="23942" checksum="7F99D72E6A4918EB" modified="2019-02-13" version="1">MSESYDFLFKFLVIGNAGTGKSCLLHQFIEKRFKDESNHTIGVEFGSKIISVVNKMVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNALTTWLSDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFVQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRAQPQGTQECGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY76</accession>
    <name>A0A3P9BY76_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Crystallin, beta B1, like 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538899.1">
        <property type="nucleotide sequence ID" value="XM_004538842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BY76"/>
    <dbReference type="Ensembl" id="ENSMZET00005015079.1">
        <property type="protein sequence ID" value="ENSMZEP00005014596.1"/>
        <property type="gene ID" value="ENSMZEG00005010981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465018"/>
    <dbReference type="KEGG" id="mze:101465018"/>
    <dbReference type="CTD" id="560055"/>
    <dbReference type="GeneTree" id="ENSGT00940000164963"/>
    <dbReference type="OrthoDB" id="5411518at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000005">
        <property type="entry name" value="Crystallin, beta B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000002">
        <property type="entry name" value="Crystallin, beta B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF55">
        <property type="entry name" value="BETA-CRYSTALLIN B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="7">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="7">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="7">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="220" mass="25452" checksum="656389ECBF000E62" modified="2019-02-13" version="1">MSAGGEKSKSASQTDGKAAQTKTSEMGLTSYKMWVYDQENFQGRCIEINAECMNVCDLGMDKVRSLRVDCGPFVGFEQMNFCGEMFILEKGEYPRWDSWSNCQKNDYLLSFRPVRMDPEKHKICLYEVGEFKGRKMEIMDDDVPSLFSYGFTDRVGSIMVSCGTWVGYQFPGYRGSQFLLEKGDYRHFNEFGARCPQMQSIRRIRDMQWHPHGCYTMSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYZ9</accession>
    <name>A0A3P9BYZ9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex I-B12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004565471.1">
        <property type="nucleotide sequence ID" value="XM_004565414.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BYZ9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014851"/>
    <dbReference type="Ensembl" id="ENSMZET00005015339.1">
        <property type="protein sequence ID" value="ENSMZEP00005014851.1"/>
        <property type="gene ID" value="ENSMZEG00005011181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479944"/>
    <dbReference type="KEGG" id="mze:101479944"/>
    <dbReference type="CTD" id="4709"/>
    <dbReference type="GeneTree" id="ENSGT00390000010316"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="92" mass="10409" checksum="64A8C4724EE525CE" modified="2019-02-13" version="1">MGGDHGHSKLSMPDWRQWKTQGTPLEFTQQRLAARGLKDPWARNEAWRYSGGFARAVTLSEVLLRGFKWGFAAFTVALAIEYTMFPPKKGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0E8</accession>
    <name>A0A3P9C0E8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat and fibronectin type-III domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="ANKYRIN REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
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            <end position="109"/>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3P9C436_9CICH</name>
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            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
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                <person name="Lara M."/>
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                <person name="MacCallum I."/>
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                <person name="Nishihara H."/>
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                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
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                <person name="Renn S.C.P."/>
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                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
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                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SANT"/>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
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    <feature type="domain" description="ELM2" evidence="12">
        <location>
            <begin position="616"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="715"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="794" mass="87245" checksum="B55B0E2D43FD511C" modified="2019-02-13" version="1">MSDCWTYSSSSTPPITYHPSQTPPSLSSPHSFRNHGNPPHAKVTSPHLFPQQQGSSSPFFHQPQINSPQTPSPHLPPPQLTSPQFAYPPVTSPHLIPHAQVTSPHPEQQPLITSPHLLSPTQHALYPELQPQISSPHLFSSSQHNFFCQNPDPDLDHSNWAKCESNSELSCLLNGNSFSYQNQTSAHLDFQNQNQFSSGLPQHEDSLENTHRSYDAQTLLFSGVCTHSDTSNPGEDSWRHLEPTVSQLQCAALDSISAGAHQADPSPHRLSVGGWSATELNPAEDFSSTQFFQDGYLNAPQPFCSPTTPGPSPHYPQTPAVSSPSPQMHPRTERTGFHTQINSDQTSDPSQYHQRLLSSQTEQMQNLTGLLHTAGTSETSLSTPRRGQHVRNAAQSMSLSTGLNWTEECGGGKGGKGGDDSHADWNWMQKEHTAESLDTRLLCMVCKRDFRSLPALNGHMRSHSGFRSSTCLKKDSAPSVQRPFTMVLPVSVPVKSRSVSKASRGGQTRSSRLPPATGSTALFRSLMRPQDEEDAAKGIKDGEKRVASAPNKGTRHYTPPPMLCPQRAGPGLYCSLTTRRQQRVQTVQLHNGARDLGAKETAFLPPGTLTSGIVKPQINLGRGFQAEIPPLQDQKYAHSDSHNALLQWTPWDDLERPVNQHRVETLLMMARSSVVPGGGASAEYTLQVLSECKGDFLLTVEKLLSTPEPNNHRHHTGVSWSAAEKRSLVKSLQLHQKDFSSIQKTVQTKSLSECVEFYYLWKKKLSLSTKTSTSLTVSLPNTNGQRSSRSQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4E3</accession>
    <name>A0A3P9C4E3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4E3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016904"/>
    <dbReference type="Ensembl" id="ENSMZET00005017444.1">
        <property type="protein sequence ID" value="ENSMZEP00005016904.1"/>
        <property type="gene ID" value="ENSMZEG00005012375.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162200"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF15">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="278" mass="30375" checksum="018988B2E813DB22" modified="2019-02-13" version="1">LAMASGSIPFPTSDCYNLRYSRLETSENNCGVPLHFFIPPLPHSSSFINRPLSSFCPPKNSMTVQKPFRLAHGTTTLGFIFQGGVIAAADTRASAGGLVACPAVHKITPIHSHLVVTSSGSGADCMLWERILIREIRLYQLRHGHRLSIRATAKLLSSMLHPFKGTEMCVALTLCGWDNGPKLIYVCSDGARLQGDVFSVGSGSPYAYGVLDRELRWSLSKGEAISLAREAVFRATHRDAYSGNNVDLFHITKSLESGNVLFDVVHQSRKSKRGENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4M4</accession>
    <name>A0A3P9C4M4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ArfGAP with dual PH domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADAP1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4M4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016989"/>
    <dbReference type="Ensembl" id="ENSMZET00005017529.1">
        <property type="protein sequence ID" value="ENSMZEP00005016989.1"/>
        <property type="gene ID" value="ENSMZEG00005012755.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101483986"/>
    <dbReference type="GeneTree" id="ENSGT00940000155698"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08832">
        <property type="entry name" value="ArfGap_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01251">
        <property type="entry name" value="PH2_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000011">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000080">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000099">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037851">
        <property type="entry name" value="PH2_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF5">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="10">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="132"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="255"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="377" mass="43629" checksum="DC0B0E36C16D6916" modified="2019-02-13" version="1">MTSDHEMIRQRVKALLDKPGNGNCADCGAAGPEWASYTLGVFVCHSCSGLHRNIAQISKVKSLILDPWTPSELEFMDSVGNNAAKAIYEQLVPAFYYCPTFKDCTVLRDQWIRAKYERKEFLCVEKQEPYSAGYREGFLWKRGRDNGQYLSRKFILSEREGVLKYFNKHDAKEPKAIMKINTLNATFQPSKMGTAHGLQITYLKDNSTRNVFVYHEDGKEIVDWFNGIRAARLRYLQVAFPLALNSELLPKVTRNYLKEGYMEKTGPKHTEGFKKRWFTMDDRRLLYFKDPLDAYARGEVFIGSQENGYIVLPNLPSTIQGYHWPFGITIVTPDRKFLFACETEVEQKEWITAFLTVINRPMLPQEYAVEAYFKHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C529</accession>
    <name>A0A3P9C529_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="13"/>
    <dbReference type="RefSeq" id="XP_024660524.1">
        <property type="nucleotide sequence ID" value="XM_024804756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C529"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017006"/>
    <dbReference type="Ensembl" id="ENSMZET00005017548.1">
        <property type="protein sequence ID" value="ENSMZEP00005017006.1"/>
        <property type="gene ID" value="ENSMZEG00005012763.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158327"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060027">
        <property type="term" value="P:convergent extension involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07876">
        <property type="entry name" value="STKc_JNK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000009">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="379"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="420" mass="47927" checksum="19554F4874C8EDA4" modified="2019-02-13" version="1">MSEAEGQFYSVQVVDSTFTVLRRYQQLRPIGSGAQGIVCSALDTVLSIPVAVKKLCRPFQNQTHAKRAYRELVLLKCVNHKNIIRLINVFTPQKSLEEFQDLYLVMELMDASLCQVIHMDLDHERMSYLLYQILCGIRHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMKYKENVDIWSVGCIMGEMVKGSVIFQGTDHIDQWNKVIEILGTPSLEFMNRLMETVRNYVMNKPQYPGVSFAELFPDWAFPSESEHDKLKTSQARDLLSKMLVIDPECRISVEEALNHPYIHVWYDPAEADAPPPQISDKQLEEREHTIEQWKELIYEEVIDWEERNKNGLMKEDCSDVVSCSASQSSSANDISSMSTEQTLASDTDSSSIDTLTGPLDENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C549</accession>
    <name>A0A3P9C549_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Aminopeptidase</fullName>
            <ecNumber evidence="23">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 23">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 23">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="23"/>
    <dbReference type="RefSeq" id="XP_012773537.2">
        <property type="nucleotide sequence ID" value="XM_012918083.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C549"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017403"/>
    <dbReference type="Ensembl" id="ENSMZET00005017955.1">
        <property type="protein sequence ID" value="ENSMZEP00005017403.1"/>
        <property type="gene ID" value="ENSMZEG00005013069.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101472801"/>
    <dbReference type="CTD" id="393175"/>
    <dbReference type="GeneTree" id="ENSGT00940000159086"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000007">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000003">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000001">
        <property type="entry name" value="Leucyl-cystinyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF156">
        <property type="entry name" value="ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3 23" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 23" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 23" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="24" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 21 23" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018217311" description="Aminopeptidase" evidence="24">
        <location>
            <begin position="39"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="27">
        <location>
            <begin position="72"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="25">
        <location>
            <begin position="289"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="26">
        <location>
            <begin position="610"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="22">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="959" mass="109599" checksum="3334FC177C403C73" modified="2019-02-13" version="1">MISAEAACRRRSGPASVVTMLVAPLLLVLFVPFSPSSGAQLPNQAKAKDLPIATNGQPFPWDRMRLPTTVTPLHYDLAIHPNLTTLDFTGVVRIELDVHEDTNTVILHAKQMQISNVFLLAPEGIKRLKVLEYPRFHQLALLSDSVLIKGRKYEVHLAFAANLSDSFHGFYKGSYRTSSGEVRVLASTQFEATFARGAFPCFDEPAFKANFTIRIIREPRHIAISNMPMVKTVELPGGLLEDHFDTTVKMSTYLVAYIVSDFKSVSKTTQHGVKISIYAVPEKIDQTAFALDAAVKLLDFYDDYFDIPYPLPKQDLAAIPDFQSGAMENWGLTTYRETGLLFDPEKSSASDKLGITKVIAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSLDITYPELHVDDFFLAKCFEAMEVDSLSSSHPVSTPVENPTQIQEMFDDVSYDKGACILNMLRDFLTPEAFEIGIVRYLKRYSYQNTVNSHLWESLTNICSSHDLDEGRLKHTEFCSKRKTQSGASKWYSGDELDVRAIMDTWTLQEGFPLVTVEVRGREVRLSQERYLKTDDPSPSEGFLWQIPLTYKTSASNTVHRFLLKTKTDVLFLPEEVDWVKFNVDMSGYYMVHYAGEGWNSIIKLLQHSHTALSGNDRANLIHNVFQLVSIEKVRLDTALELSLYLSRETKIMAVTQGFGELVPLYKLMEKRDMKVLENQMKSYIVDLFQDLIDQQEWNDSGSVSQRVLRSYLLLFSCVRNYAPCVTKATQLFNQWKDSDGTMSLPVDITMAVFVIGARTPEGWDFLFEKYRHSLQMSVKSRMKTAMAVSPLQDKLKWMMEQSLIGEIMKTQDLPDVVVSVSKNPHGYQLAWDFLRANWHTMIKKFDLGSSTISYLVTGVTNQYSTREMLDEVRSFFGSLTEETGSEMRCIQQAYETIEDNIRWMDKNLPLLQAWLDKRNRRVSHEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C5S2</accession>
    <name>A0A3P9C5S2_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Transmembrane protein 164</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004557377.1">
        <property type="nucleotide sequence ID" value="XM_004557320.4"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005017404"/>
    <dbReference type="Ensembl" id="ENSMZET00005017956.1">
        <property type="protein sequence ID" value="ENSMZEP00005017404.1"/>
        <property type="gene ID" value="ENSMZEG00005013086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471883"/>
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    <dbReference type="CTD" id="84187"/>
    <dbReference type="GeneTree" id="ENSGT00390000007430"/>
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        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026508">
        <property type="entry name" value="TMEM164"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20948:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 164"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TMEM164"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="313" mass="35545" checksum="2760B5E851261586" modified="2019-02-13" version="1">MFRQEVGVASFIPSCSYLFQHEKRNMSRYNIYSLLDWIYGGVDPKFEGNGGPECAAFLAPQQRISESLVIVLISLVEILVALKKINISKELRVAGKDCIRAKEDSLGKNLLLVTLCMTFGVEVGFKFATKTLIYLLNPCHVVTMVQIFLLACPPCKTAMVVFRLQVHMLNGALLALMFPVVNTRLLPFEKEIYYIQHSMMYLVPVYLFRKGGVYKPEPLGDMWWAVLSTGILFFYHFTFLQLLGLATEVNLNNMLCPAVSDPFYGPWYRVWATGHQTLLTLIHGKLLTLLSQHSGTACRYLLDTLRLRSKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C619</accession>
    <name>A0A3P9C619_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vasodilator stimulated phosphoprotein b</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C619"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017336"/>
    <dbReference type="Ensembl" id="ENSMZET00005017883.1">
        <property type="protein sequence ID" value="ENSMZEP00005017336.1"/>
        <property type="gene ID" value="ENSMZEG00005013032.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156765"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005522">
        <property type="term" value="F:profilin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000005">
        <property type="entry name" value="vasodilator-stimulated phosphoprotein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014885">
        <property type="entry name" value="VASP_tetra"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF12">
        <property type="entry name" value="VASODILATOR-STIMULATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08776">
        <property type="entry name" value="VASP_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VASP tetramerisation" evidence="3">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="294" mass="30647" checksum="396C3D522C77256A" modified="2019-02-13" version="1">QICLFVHRLEQQRLEQQDRERQERERQERERQERERLERERQAAAVPPAPPAPPLATGGPAPPPAPPPPPGPPPAPAPPPAAGIPPPPGPPPTGPPPAPPLPTSGGGNGIGGGGGGAGGGLAAALAGAKLRKVSKQDDGPSAPPTPTPVSRTESTRSSNASIGGGGGGGGLMGEMSAILARRRKAADTGEKPPVKPQDNDESESPSQSDAVRRPWEKPSMIRNNSIPKSMDSTSSLSQVPRAKAASNNNEASGADDSDLEKMKQEILEEVRKELQKVKEEIIGAFIQELQKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7Z4</accession>
    <name>A0A3P9C7Z4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">V-set and immunoglobulin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004557382.2">
        <property type="nucleotide sequence ID" value="XM_004557325.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7Z4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018390"/>
    <dbReference type="Ensembl" id="ENSMZET00005018984.1">
        <property type="protein sequence ID" value="ENSMZEP00005018390.1"/>
        <property type="gene ID" value="ENSMZEG00005013807.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101473139"/>
    <dbReference type="GeneTree" id="ENSGT00940000160507"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003382">
        <property type="term" value="P:epithelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030277">
        <property type="term" value="P:maintenance of gastrointestinal epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029861">
        <property type="entry name" value="VSIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44974">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44974:SF1">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018335551" description="V-set and immunoglobulin domain-containing protein 1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="141"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="309" mass="33161" checksum="BED6ADC7ADBA9FEC" modified="2019-02-13" version="1">MCSVQLLLVLLSITGCVELITVTTTQKYVNVTIGGSVLLDCTFATTVATTADLTIQWEFLSKSAMTAQQIFYYQSGKVVIPKSYEGRIQTPAAPGATMNASITIRNMQPSDSGLYTCEVHNLPDVDGQSQANIIVNVLEKPSAPYCAVHGNVESGHLVTLTCHSEQGNPTPTYNWAKLDQTKTRRPVLGRTTTTGILEIKNISQFEFGEYQCIATNVVGFATCTIELSPEVADGVIAGAVIGALLGCVLIGLVAWFIAHTVKKHKYNAVKMAEANEMKGSSPPAQEPYESIPNANTADNVQDEEEGPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8N5</accession>
    <name>A0A3P9C8N5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal protein CCDC61</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">VFL3 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CCDC61 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573380.2">
        <property type="nucleotide sequence ID" value="XM_004573323.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8N5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018628"/>
    <dbReference type="Ensembl" id="ENSMZET00005019228.1">
        <property type="protein sequence ID" value="ENSMZEP00005018628.1"/>
        <property type="gene ID" value="ENSMZEG00005013984.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478302"/>
    <dbReference type="KEGG" id="mze:101478302"/>
    <dbReference type="CTD" id="729440"/>
    <dbReference type="GeneTree" id="ENSGT00940000154133"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22284">
        <property type="entry name" value="HD_CCDC61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049733">
        <property type="entry name" value="CCDC61_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN CCDC61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="307"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="509" mass="58036" checksum="B9A65F1049E0DD03" modified="2019-02-13" version="1">MEGGSELMEDIVFRGVEFSVKMEVDKGLLIVEISDSMTADQWTGEFDPAYIEDLTRKTGNFKQFPIFCSMLESAVRKTSDSVTLDLLTYADLELLRNRKAGVVSRPRSHQQPSALTAKRYLILIYTVEFDRIHYPLPLPYVGKPDPAVLQKEIRALRAELSALTSHGVNKSADLEIQRLRAELALVKEEKESMAKVLERLQLSGNDPTSGREDWRMRDVVRTLEEQLVKERAKSQRSMSKRCQEQRLLVEQLEELRASECALRVRVKSLTNELALLRRGRVTPVSGRISSRVDGEIYRSLSRERRSGYGTIRARSGSRERTEDRGQRLVERGRRADSSGPRAHIPRPSPSPTGSRVPRFDPTAYIQDRQRRQKEAEIKKQRKVRRDMLASPVLPERGRSRSREAYPQLTRSGSRGRSLSMERRGSRNSSESSLVDMDEMTKTLYRGRKQTYNGPNVSRGGLLSRKPLCSTPTLRVKDKESSVDTGTELSEIDARLQALQEYMRDLDTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAH2</accession>
    <name>A0A3P9CAH2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PMS1 homolog 1, mismatch repair system component</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559192.2">
        <property type="nucleotide sequence ID" value="XM_004559135.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004559193.2">
        <property type="nucleotide sequence ID" value="XM_004559136.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004559194.2">
        <property type="nucleotide sequence ID" value="XM_004559137.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004559195.2">
        <property type="nucleotide sequence ID" value="XM_004559138.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004559196.2">
        <property type="nucleotide sequence ID" value="XM_004559139.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004559197.2">
        <property type="nucleotide sequence ID" value="XM_004559140.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAH2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019285"/>
    <dbReference type="Ensembl" id="ENSMZET00005019907.1">
        <property type="protein sequence ID" value="ENSMZEP00005019285.1"/>
        <property type="gene ID" value="ENSMZEG00005014474.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101488039"/>
    <dbReference type="CTD" id="5378"/>
    <dbReference type="GeneTree" id="ENSGT00940000157085"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03485">
        <property type="entry name" value="MutL_Trans_hPMS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000026">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000030">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF54">
        <property type="entry name" value="PMS1 PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="533"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="533"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="897" mass="99570" checksum="4D9B99B9BB4D4E77" modified="2019-02-13" version="1">MKQLPPDTVRLLSSSQVITSVVNVVKELIENSLDAGASSIDVKLENFGLDRVEVRDNGQGIKTVDTPVMAVRHFTSKICRHEDLEHLETYGFRGEALGSICAVAEVAVTTKTEEDEISTQYTMDLTGKIVSQKPSHLGQGTTVSVMKLFKNLPVRRQCFSSTKKCKEELKKVQDLLMAYAIIKPELRLMLVHNKVVLWQKAKVADNRSALLATLGPGAIANLIPCHHHQEQPEILLEGFFPKPGADYSSTSTSNPDKTFIFVNNRPVQHKEIMKLLRQHYTAQYADDQARNRYPTLMLKISVPPSSVDVNLTPDKTQVLLHNKETVLTAIEALLVSLYGFRPNADLPADKHLSSEPFPSPSSPLQADSERNAENSHSNDSVPRDGPKQSSADTSLDRQASNCSSSSSIADDWIVNQIPADLESNFSLYDDEMSQTVTKPASKSPERLVDNKMTAATISKVQISAEDWSRGTALTDPVSGEPLQPVIIHRPTKQNHSVPDEAMSESSSSKKTLNAITEKRAALTAYDMISNRTMRAPLSPVTIFEKEARAEVLREKPTASLQDISVAIHERWKNLREEDRKKYEEKAKKHLEHHEQRTKLASAEGPREPGVRSHMQGQKRKAPLSNQQLLDELFAAQPQKKMKNPAPKPSQPLPCSVAALRLQLQRLSSQSSAAPQGLRLVNRLASQSAWVILCGQRLMLLNPFRVEEALLFKRLLENNILPAASLQNPIQLTDGSLGGAEYTEALCSMEKQSPELNGAAFFSDPRLVANGFKVKLTPGVTSAERHLEVTAMADCVPFLGVEDLREILTAVLHKKARTVRECRPLKVTNYLQGEAVRLTRQLPTNLSREDVKETLLQMEQQLGGANHTCIHGRPFLQHLTDVPTTEQEVKALLRPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAI6</accession>
    <name>A0A3P9CAI6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neuropeptide Y</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NPY family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A3P9CAI6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019127"/>
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        <property type="gene ID" value="ENSMZEG00005014357.1"/>
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        <property type="component" value="LG11"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:neuropeptide Y receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:feeding behavior"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:neuropeptide signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Hormone_3"/>
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    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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    <feature type="chain" id="PRO_5018186915" evidence="5">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="122" mass="13888" checksum="3F2598C850F38C18" modified="2019-02-13" version="1">MSLSILALCLLVCIHSGINAYPAKPANPRQGAPPEELAKYYSALRHYINLITRQRLVIYFYIIESILTLYGKKYCLIADIFFMHRYGKRDSPDTVFSDVLVRESTESVPGSSYIRYDGLPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CB97</accession>
    <name>A0A3P9CB97_9CICH</name>
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            <fullName evidence="5">Protein HTATIP2</fullName>
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        <name type="scientific">Maylandia zebra</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
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                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
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                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
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                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="4">Monomer. Forms homodimers during oxidative stress. Interacts (via N-terminus) with elongation factor EEF1A1 (via middle-region); the interaction is direct and competes with EEF1A1 binding to guanyl-nucleotide exchange factor EEF1B2, thereby inhibiting GDP for GTP exchange and reactivation of EEF1A1. Interacts with nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA.</text>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
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    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
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        <location>
            <begin position="15"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEH1</accession>
    <name>A0A3P9CEH1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Schwann cell-specific EGF-like repeat autocrine factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEH1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020650"/>
    <dbReference type="Ensembl" id="ENSMZET00005021330.1">
        <property type="protein sequence ID" value="ENSMZEP00005020650.1"/>
        <property type="gene ID" value="ENSMZEG00005015496.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165119"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000020">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000774">
        <property type="entry name" value="von Willebrand factor D and EGF domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="196"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="276" mass="29209" checksum="970178A446B65789" modified="2019-02-13" version="1">MFHANMDCIDLIQSLEKQPQPPPQGALPAPPHHHHPGREVFPVSSGDFLLLHPSTASLLFTLHLSNKAHPAMFFAPLLFASLMSLAGVCSGGSDAPRGVAVGFVFDLKAKCEPPCEHAGVCIRNNTCFCSRGYEGETCQYANCDPKCKNGGVCLRPGKCRCPPGFGGRYCHKVTCDGGCWNGGECTAVNGVAKCICPSSWAGSKCQEAICPQGCRNGGLCVAPGICSCTEGWLGGACHMAVCSQPCLHGGKCVSPNKCRCRPPFSGPRCEERKKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEX7</accession>
    <name>A0A3P9CEX7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TAFA chemokine like family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TAFA5</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAFA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553997.1">
        <property type="nucleotide sequence ID" value="XM_004553940.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEX7"/>
    <dbReference type="Ensembl" id="ENSMZET00005021384.1">
        <property type="protein sequence ID" value="ENSMZEP00005020702.1"/>
        <property type="gene ID" value="ENSMZEG00005015542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474496"/>
    <dbReference type="CTD" id="25817"/>
    <dbReference type="GeneTree" id="ENSGT00940000160682"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020350">
        <property type="entry name" value="Chemokine-like_TAFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040329">
        <property type="entry name" value="TAFA-5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31878:SF0">
        <property type="entry name" value="CHEMOKINE-LIKE PROTEIN TAFA-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31878">
        <property type="entry name" value="CHEMOKINE-LIKE PROTEIN TAFA-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12020">
        <property type="entry name" value="TAFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="125" mass="13616" checksum="858C78B609AB1E37" modified="2019-02-13" version="1">MQLLRVAWALTGAAICCFLILLIHSRLLKEGQLAAGTCEIVTLDRDSSQPRRTIARQTARCACKKGQIAGTTRARPACVDAGIVRKKQWCEMVPCLEDEGCDLLVNRSGWTCTQPGGRVKTTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CG12</accession>
    <name>A0A3P9CG12_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Retinoic acid receptor RXR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nuclear receptor subfamily 2 group B member</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Heterodimer; with a rar molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CG12"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021220"/>
    <dbReference type="Ensembl" id="ENSMZET00005021919.1">
        <property type="protein sequence ID" value="ENSMZEP00005021220.1"/>
        <property type="gene ID" value="ENSMZEG00005015929.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159789"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06956">
        <property type="entry name" value="NR_DBD_RXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06943">
        <property type="entry name" value="NR_LBD_RXR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000002">
        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000005">
        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021780">
        <property type="entry name" value="Nuc_recep-AF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11825">
        <property type="entry name" value="Nuc_recep-AF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="166"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="261"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="496" mass="54450" checksum="2A070DF98FC3F2E3" modified="2019-02-13" version="1">METKPFLSLGFLKPQCSLAPPMQRGRSGDACSCFSGVCPLHDRRLSSDSSGQVTSSPLGSPTSHRGMHPSLLSPTSMGPSGPLHSPISTLSSPMNGLASPFSVISSPMGPHSMNSPGMGYGPSVSPQLNSPMNSVSSTEDIKPPLGLNGVMKVPAQPSSTALSLTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCVIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRAKEKNENEVESTSCANEDMPVEKILEAEEAVEPKTETYIETNLGVPSNSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPGEVEALREKVYASLEAYCKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGB1</accession>
    <name>A0A3P9CGB1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">GABA(C) receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGB1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021333"/>
    <dbReference type="Ensembl" id="ENSMZET00005022037.1">
        <property type="protein sequence ID" value="ENSMZEP00005021333.1"/>
        <property type="gene ID" value="ENSMZEG00005016015.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156864"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19005">
        <property type="entry name" value="LGIC_ECD_GABAAR_rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19059">
        <property type="entry name" value="LGIC_TM_GABAAR_rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000007">
        <property type="entry name" value="Gamma-aminobutyric acid type A receptor rho2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000005">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit rho-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008057">
        <property type="entry name" value="GABAAa_rho_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01670">
        <property type="entry name" value="GABAARRHO"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5022271790" description="GABA(C) receptor" evidence="18">
        <location>
            <begin position="21"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="64"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="271"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="469" mass="54081" checksum="ADC7AA525D2E2323" modified="2019-02-13" version="1">MPRYTRVLLLVLCVSLIGECRKHRSRKKRWSAPAGTHKPANPLSKKVVDGTKSRKVKTSHLLRIDEHDFTMRPAFAGPAVPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFPSTTNKSMTFDGRLVKKIWVPDVFFVHSKRSFIHDTTTDNIMLRVFPDGHVLYSLRVTVTAACNMDFSRFPLDSQTCTLELESYAYTDEDLMLYWKSGDESLSTDDRISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTLRDGKDRKLREKSRTLPCTCGMPHTKTMMLDGTYSEEDANSLAGYTRASMVAEDISDKQEQMVVHLSLDNESTGTKKKGIRGFRIIQNTHTIDTYSRMIFPGSYILFNLIYWCVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHE8</accession>
    <name>A0A3P9CHE8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transmembrane protein 267</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004538434.1">
        <property type="nucleotide sequence ID" value="XM_004538377.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHE8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021715"/>
    <dbReference type="Ensembl" id="ENSMZET00005022428.1">
        <property type="protein sequence ID" value="ENSMZEP00005021715.1"/>
        <property type="gene ID" value="ENSMZEG00005016290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484435"/>
    <dbReference type="KEGG" id="mze:101484435"/>
    <dbReference type="CTD" id="64417"/>
    <dbReference type="GeneTree" id="ENSGT00390000003050"/>
    <dbReference type="OrthoDB" id="10014558at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026572">
        <property type="entry name" value="TMEM267"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13628">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13628:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="247" mass="27014" checksum="75A2E6937E63DFAD" modified="2019-02-13" version="1">MQGFYSKLDSSPSSSPLLGPGLRGDGAPVPLSLALETERAQALLQTFSSASLLASAGLGMFCVVADHVLQLSVIQQHLWLRAVLDNATHGLVGLWSWAVVIGLRKKSDLYEVLLAGLLASIIDLDHFYMAGSLSLKAAVSLPQRPPLHCSSLIPIICLTLRFLMWLGRLKDAWCSLPWMLFISMVTHHVRDAVRHGLWVCPFGNTAPIPYWLYVSTTATLPHLCSVLMYLTGTRDVIFTKHGVAIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHQ4</accession>
    <name>A0A3P9CHQ4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004566248.1">
        <property type="nucleotide sequence ID" value="XM_004566191.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHQ4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021564"/>
    <dbReference type="Ensembl" id="ENSMZET00005022274.1">
        <property type="protein sequence ID" value="ENSMZEP00005021564.1"/>
        <property type="gene ID" value="ENSMZEG00005016193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468340"/>
    <dbReference type="KEGG" id="mze:101468340"/>
    <dbReference type="CTD" id="23491"/>
    <dbReference type="GeneTree" id="ENSGT00940000166187"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017856144" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="27"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="559" mass="61567" checksum="2E878472660AB639" modified="2019-02-13" version="1">MRTALFIVYVLPVLIVVAQATPAGRSDLVVSAKNGQIRGEYVSVKGTERRAKCYLGIPFAQPPVGDLRFSAPRPEEPWEGVRDGTQEPSMCIQDPELVVNVSKTMLLEFIPPAISEDCLYLNVYTPAEATKGNKLPVMVWIHGGGLAMGAASQYDGAPLAVYENIVMVIIQYRLGILGFLSTGDEHAQGNWGFLDQLAALRWVQENIEAFGGDPQTVTVAGESAGGISASILTLSPQAKGLFQRAIFQSGVATLGTYTTNHPLSQAQIVANHIGCNHSSTEELIRCMKGKSQDELVAATKQMKIFLGAVVDGEFLTDLAEALLQKHEVLKVPVLMGITNHEFGWILPQSFAVPGWENGMNRETVLAVVNMFNPPGASFVNNLIVDEYLQDAKTPEEIRDRFTEIIGDLLMTLPVVRVAGYHSDVGVPVYMYEFAYQAEIYKHNRPSFVKADHADDVGLMFGGCFWNGNIKILGNITKEDERFCRTMMSYWANFVRDGSPNGPGLVSWPQYNRQNQEYMELGPTQTVKQKLRKDRVHFATVTLPLKLRELEAAAKLVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHT7</accession>
    <name>A0A3P9CHT7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fas apoptotic inhibitory molecule 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAIM1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHT7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021599"/>
    <dbReference type="Ensembl" id="ENSMZET00005022309.1">
        <property type="protein sequence ID" value="ENSMZEP00005021599.1"/>
        <property type="gene ID" value="ENSMZEG00005016212.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007364"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.180:FF:000001">
        <property type="entry name" value="Fas apoptotic inhibitory molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.180:FF:000002">
        <property type="entry name" value="Fas apoptotic inhibitory molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.180">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FAIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038513">
        <property type="entry name" value="FAIM1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088:SF3">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13088">
        <property type="entry name" value="FAS APOPTOTIC INHIBITORY MOLECULE FAIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06905">
        <property type="entry name" value="FAIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00058770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="191" mass="21077" checksum="858740F7999B2B03" modified="2019-02-13" version="1">LAQGISSEGLTMSNDLAGVWEVALSDGVHRIEFEHGTTTGKRVIYVDGKEVLRRDWMFKLVGKETFSVGSSDTKATINIDAVSGFAYEYTLEINGKSLKKYMENRSKVTSTWLLNLDGIDCRVVLEKDTMDVWCNGQNIETAGEFVDDGTETHFTLGDHNCCVKAVSSGKRRDGIIHTLLVDGTEIAECTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQW4</accession>
    <name>A0A3P9CQW4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Titin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQW4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024738"/>
    <dbReference type="Ensembl" id="ENSMZET00005025547.1">
        <property type="protein sequence ID" value="ENSMZEP00005024738.1"/>
        <property type="gene ID" value="ENSMZEG00005018476.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286978"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048738">
        <property type="term" value="P:cardiac muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd05748">
        <property type="entry name" value="Ig_Titin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000002">
        <property type="entry name" value="Titin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000011">
        <property type="entry name" value="Titin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000034">
        <property type="entry name" value="Titin isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000003">
        <property type="entry name" value="Titin isoform E"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000073">
        <property type="entry name" value="titin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14340:SF13">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="64"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="162"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="255"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="442"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="541"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="642"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="742"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="838"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111487" checksum="E7C3A71D8BE0A309" modified="2019-02-13" version="1">MRETTGTSWVELAATVIRTTFKAARLTTGTQYQFRIKAQNRYGIGPSIISEPVVAVYPFDVPSQPGTPVVTSFNKDAMTLSWNEPSSDGGSAILGYHVERKEKNSILWQRISKALVVGNLFKSTGLIDGIAYEHRVIAENMAGLSKASKPSEPMYALDPVDPPGRPVALNITRHEVTLSWTKPEGDGGFSITGYTVERREMPNGRWLKANFNNILETIYTVSVEPLPEVYAENIVGIGECSKVSEVYVARDPCDPPSRPEAVIVTRHSVKLKWNPPAYNGGSLVTGYLVEKRDLPEGKWMKASFTNIIEHEFTVTGLTEDSKYDFRVIAKNAAGAVSKPSESTGSITAKDEVVPPKSETDPMYNQTIVINAGETFNLEASVEGKPIPTAQWFKGNLEVENSARAEIRNTDFKALLVVKDAIRVDGSKTIPFSVKVLDRPGPSEGPLTISNVTEEKCSLSWLPPRHDGGASISHYIIQKRETSRLAWTVVCSDCKATMFKVTKLLKGNEYIFRVMAVNKYGTGEPLESAPVIMRNPFVPPGAPQDLEITNITRDSMTVCWNRPETSGGSDIVGYIVEKRDRAGVRWTKCNKRRVTDLRFRVTGLTEDHEYEFRISAENAAGVGQPSPSTTYLKACDPTFEPGCPTNVHVVDTTRDSICLAWHRPIYDGGCEIQGYAVEITKADEEEWAICTPPCGVNATKFTIKKLIEHQEYKVRICAINKVGVGEPTEIQGVVKPMDKIDPPEVILDSELRKGIVVRAGGSMRVCIPFKGRPTPEINWAKEDGELPSKVQVETGEDYTQLSIEICDKYDAGKYVLNLENSAGTKSAFVSVKVLDTPGAPLNLTVTDIKRESVTLTWEPPLIDGGARIKNYLVEKRESTRKVYSNVDNKCTKTSYRITGLTEGTIYYFRVLAENEFGVGQPAETEESVKTSEPPLPVGKNAVGSVSNPSITVGPATCVDTYGRSFHVGLYLCIFFCNYALSCILRYLFHTLHILHPDLFYHLWSRCPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSN3</accession>
    <name>A0A3P9CSN3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSN3"/>
    <dbReference type="Ensembl" id="ENSMZET00005025625.1">
        <property type="protein sequence ID" value="ENSMZEP00005024816.1"/>
        <property type="gene ID" value="ENSMZEG00005018533.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10030" checksum="D172307208DB936E" modified="2019-02-13" version="1">EDVEHFGKHYKVEAFLGEGGFGIVAKCRDTTTNQAVAIKSTRATLIFCNRHMWKFSSWSSCEGWIQMPPTLFNGTAFPRRTAGLPEFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSY1</accession>
    <name>A0A3P9CSY1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actinodin1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004551908.1">
        <property type="nucleotide sequence ID" value="XM_004551851.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004551909.1">
        <property type="nucleotide sequence ID" value="XM_004551852.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSY1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025448"/>
    <dbReference type="Ensembl" id="ENSMZET00005026272.1">
        <property type="protein sequence ID" value="ENSMZEP00005025448.1"/>
        <property type="gene ID" value="ENSMZEG00005018990.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487464"/>
    <dbReference type="KEGG" id="mze:101487464"/>
    <dbReference type="CTD" id="794315"/>
    <dbReference type="GeneTree" id="ENSGT00500000045505"/>
    <dbReference type="OrthoDB" id="8682554at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033333">
        <property type="term" value="P:fin development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018329066" evidence="2">
        <location>
            <begin position="30"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="611" mass="68689" checksum="3DEDDB4E3B03BF34" modified="2019-02-13" version="1">MAERRRTSFSGVLITIVLAVMLLPAFLSAGPIVQKPRGDAGESIQEKAAAAAAHRRLIRNRRNISWYKQHSDFWAWYKYFTDNGNQEAIQEMDRIFLAYLQNKNRAEGRRSYKAYLRHLGDVYKSCSDTEDPNCVASYTSRASPKAEPPKPAPVKTCDPTKDPYCMYMALVQGKSPYKPLVLPAATPAPQYVHSPAPAKDPQSGYYYYSPSTMPFLTMEQKVELLRICGSDDVECLQYHLKAAYGYSGGSRPSYAHLGCDPKKDPACKMLQKAPAGLYMNAYSASSTAPQAAPGSCNPLFEDGCNPLTATRFSTSPESYKSNERDQAAAIRAAPPAEQYDPYSMYRDSYSNVNRVTDPYAMYRQASAPTSPPATDLFAVLRQYMAQAHTNDPYAPRMGAASESNSNDPYSTMRDAAGAMHLHTPPSPRQQHPYSYPSYEEPAQEERHPLGPPGKTKEGYDCFIGYDRECYPVKPSAPRSGVQRRIPYPAEAYEPHLNSDGTRNGVLEPVNPHCDPEYDRDCRLRRYETEQPQSQPERHAAEDHSQTAAEREQVNQDQYEAEPYQSGQEESHTPYQPLSQGMPSLQDILRRYGDQYPGQEDHRAYADNYHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CTG2</accession>
    <name>A0A3P9CTG2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S-adenosylhomocysteine hydrolase-like protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="5">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CTG2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025638"/>
    <dbReference type="Ensembl" id="ENSMZET00005026471.1">
        <property type="protein sequence ID" value="ENSMZEP00005025638.1"/>
        <property type="gene ID" value="ENSMZEG00005019121.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182981"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000002">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000009">
        <property type="entry name" value="Adenosylhomocysteinase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF2">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="7">
        <location>
            <begin position="246"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="277"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="470" mass="51997" checksum="0A4BB3CF4690A6A5" modified="2019-02-13" version="1">MILQQIPFTGQKQEFNRPPTRTVRSMSQSSTDSFASVHSDTSDDESSPRDKLQKSTKGPSDFCIKNISQADFGRKEIEMAEQEMPALMNLRKRAGGEKPLAGAKVVGCTHITAQTAVLIETLAALGAQCRWAACNIFSTQNAVAAALVKAGISVFAWRGESEDEFWWCIDHCVGTETWQPNMVLDDGGDLTDWIYKKYPELFKNLKGVVEESITGIYRLYQLSKAGRLSVPAMNVNDSVTKQKFDNLYFCKESVLEGLKRTTDIMFGGKQVVVCGYGEVGKGCCAALKALGAIVYVTEVDPICALQACMDGFRVIKLSEIVRHIDMVITCTGNKNVVMREHLDKMKNGCIVCNMGHSSSEIDLVKTHVVCACIAALTCSTVPSFVLSITAATQAMALIELYNAPEGRYNKDVYLLPKKMDEYVASLHLPIFDAHLTELSDDQAKYMGISKHGPFKPNYYRHKLLSHIDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CV30</accession>
    <name>A0A3P9CV30_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. Maf subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557605.1">
        <property type="nucleotide sequence ID" value="XM_004557548.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CV30"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025924"/>
    <dbReference type="Ensembl" id="ENSMZET00005026761.1">
        <property type="protein sequence ID" value="ENSMZEP00005025924.1"/>
        <property type="gene ID" value="ENSMZEG00005019336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483581"/>
    <dbReference type="KEGG" id="mze:101483581"/>
    <dbReference type="CTD" id="23764"/>
    <dbReference type="GeneTree" id="ENSGT00940000161112"/>
    <dbReference type="OrthoDB" id="5974330at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045604">
        <property type="term" value="P:regulation of epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14717">
        <property type="entry name" value="bZIP_Maf_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000011">
        <property type="entry name" value="Transcription factor MafG, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="208" mass="23508" checksum="422A9B54B0F786A1" modified="2019-02-13" version="1">MKESNLREQRSNSGKRRTDILSPELRRAIRLCVSGFTGAWGGEKNKDNWTMTTERNSKALKVKQECGENVPFLSDSELMSLSVRELNLHLRGLSRDDIQKLKQRRRTLKNRGYAASCRVKRVSQREALEQQKMELQREVERLGAENAGMRKELEGLSARLAALQRFARGLEAGGGSLLATAPRLNTASVITIVKSPQQPQPQREHELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CW77</accession>
    <name>A0A3P9CW77_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interferon-induced GTP-binding protein Mx</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Interferon-inducible Mx protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004557272.2">
        <property type="nucleotide sequence ID" value="XM_004557215.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CW77"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026329"/>
    <dbReference type="Ensembl" id="ENSMZET00005027178.1">
        <property type="protein sequence ID" value="ENSMZEP00005026329.1"/>
        <property type="gene ID" value="ENSMZEG00005019640.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101467302"/>
    <dbReference type="CTD" id="557996"/>
    <dbReference type="GeneTree" id="ENSGT00940000166903"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000045">
        <property type="entry name" value="dynamin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF54">
        <property type="entry name" value="DYNAMIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="16">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="527"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="15">
        <location>
            <begin position="660"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="748"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="795"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="828" mass="92957" checksum="70A42B528B814A0F" modified="2019-02-13" version="1">MGNRGMEDLIPLVNRLRDALSSVGESCSLHLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLLSDNTEYGEFLHCQGKKFTDFDEIRKEIETETHRLTGSNKAISPVPIHLRIHSPHVLNLTLVDLPGITKVPVGDQPTDIEYQVRDMIMQYICKENCLILAVTPANTDLANSDALKLAKDVDPQGLRTIGVITKLDLMDEGTNARQILENKLLPLRRGYIGVVNRSQKDIDGKKDIKEALRAEKEFFLSHPAYKHMSEKMGTPYLQRILNQQFTNHIRDTLPAFRSHLQSQLLALKKEAEDYMQFNPNDPARRTKTLLQLVQRFAVDFEKLIEGSGDKVDTVNLSGGAKINRIFHERFPYELIKIGSDEGKLRTEINYAIRNTHGVRTGLFTPDTAFEAIVKKQISRLKGPCVKFIDMVSQELTTTLYQCIDKLSSFPKLRDETERIVTTEIRELETKCRDQVMLLIDIQVAYINTKHEDFVGFNNSPQMHNHTNTKIAARIGGKQGVAPHSSLIVIRKGWLTINNIGIMKGGAKEYWFILSAENLSWFKDDKEKEKKYMLPLDNLKLRDVEKGFMSSKYVFAIFNTELRNVYKDYKCLELACNSQEELDSWKASLLRAGVYPEKVAVDEQGNGPPENLSDPQLERQVETISNLVDSYMGIIYKTVRDLMPKTMMHLMINSVKEFISSELLAQLYALGECSALMDESPEQQQHRVEVLQKHAALKEALAAIGEISTSTCTTPLPPPVDSSWIKPSSLPKTAASGKPGIRSHAPPVPRVPSAGPKSSPNGSRQHTSQQNRTPALVPRRLPPAIPSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CWI4</accession>
    <name>A0A3P9CWI4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004549708.2">
        <property type="nucleotide sequence ID" value="XM_004549651.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023010975.2">
        <property type="nucleotide sequence ID" value="XM_023155207.2"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005026750"/>
    <dbReference type="Ensembl" id="ENSMZET00005027608.1">
        <property type="protein sequence ID" value="ENSMZEP00005026750.1"/>
        <property type="gene ID" value="ENSMZEG00005019947.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101479052"/>
    <dbReference type="CTD" id="115701"/>
    <dbReference type="GeneTree" id="ENSGT00940000160524"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47091:SF2">
        <property type="entry name" value="ALPHA-PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47091">
        <property type="entry name" value="ALPHA-PROTEIN KINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="12">
        <location>
            <begin position="1224"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="833"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="930"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1459"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="834"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="890"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1459"/>
            <end position="1476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1490" mass="162465" checksum="6C0557AAEB6F2246" modified="2019-02-13" version="1">MDASLPCADSQSQPALTDSQTVDFDSVMHSPSVDKLSGTETAHCLSDTTDKSTHPHVSADPHSLKSLSSIQNVSEQFSLSSEAPPTDDNSRVQRCLSQSGRKSPLIRQLCQDLILPQSESASSLLMEGHTPPESFGAVSLTLEGLMEQSVTVPYSSPNFSSENKPPLFRSLSPQSDSSDSDMAVAPLSALYIFESDTQDFIVSPSIAPGEIKCSEYQPLSQTSVEQVNRDCDKHVLMCDSSDVTGCHHSSCEEQSTENNEPDVSEHLGLRTPAVDACEEYFMFLNDEREGEAEVTGATPQRGNSPMEVWQDAHQYLAGDDTEDRDVLHHSVIQEALSPASHLSCSPRETQVSHYNPEGSKGIGWTGDDTKGWGPPIERWSSVDSWASALSDWTGIIVAPSEDFTSAFSEIGAEIDALTQALSEVNTHTEAETVKEGHNLETTAKAQMGVQDQPLSAQNISESSIHSGQGCLSLYLDSTGLEPHHTEGAESFCDPTPTTQGDKCSPSRGAPGTTVASSGENTADATVVTLMPGSTSADLDLSPFDECAESQDTEHFIIDEKTSVVLSIIEDTDLDPPTDLITKEPVGDRLCEVTDEHRLVQLGSVAKPEAKLSCGRSEVNRDENKSITDFSVLTADALTNSNVPGGDTQPGLHFNADNCVSIGTLPDLDRAHQVEAQRDSPTFIMPLAPVSIGPSLNCRTSSSLEGDQICLKGSLNNNSCNQVRQSAVLPTPDGITNKTSLEGGEELIHEKQNTTKTAERSSPEGLQDLKTSDTIDSFFSRKTIFEEIDDFNRELENFIPIHAENLFISKEKHIACITLDIYDPFVSKPVKPKAIKSEKTDLTHKKTEKMPHKTHKNTSEGKTRSKKDKSAGHHHFTQPSKKQESKCHRVSAQQTSNQQETHPTIGKNHSSENSQSGLEAKEATLVIETGVTEKATSKPHSKKKKKHGQNTAPGEPLAEVENGAKSKTAKGRIELFESKLGAKAGKAQKESEQPDVAEIKSQQQSEAKASEGEQPPHPTDDKGHQPKNFTSPLNDDVVKRRRLSEDKFGKIVSILESKLPKSDVSAKGKEAELKTDVGGTRKKAYSEVVKQRIPPKEEPKVVKPIQAVPVSGDPQSLCLWCQFAAVTSAYTVTWSREGTVLAEMKRSAGDESRVTLTISNASHKDLGKYLCQLSSLYGSVSLDYLLTYEVLSEVVIPLAPKTISSDPVEVSSEEEDAHFSRLLFKDDFLSDQYFGDSHPISMITEKEHFGEGMHRRAFRTKLHAGQIPLLLPGHSCVLKVHNAISYGTKNNDELVQKNFTLAVEECQVQNTAREYIKAYTSAAQSTEAFGDIPEIIPIYLIHRPSNDIPYATLEEELIGNFVKYSVKDGKEINLMRRDSEAGQKCCAFQHWVYQKTDGNLLVTDMQGVGMKLTDVGIATCKKGYKGFKGNCGTSFIDQFKALHQCNVYCEMLGLKSLQPKAKKPASAPKPKPQSSTPPKKKTFGPVVKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZE7</accession>
    <name>A0A3P9CZE7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rubicon like autophagy enhancer</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZE7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027347"/>
    <dbReference type="Ensembl" id="ENSMZET00005028219.1">
        <property type="protein sequence ID" value="ENSMZEP00005027347.1"/>
        <property type="gene ID" value="ENSMZEG00005020397.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160585"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagosome maturation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagosome-endosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Autophagy_HostDef_Reg"/>
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        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048569">
        <property type="entry name" value="RUBC_PIKBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971">
        <property type="entry name" value="PHOX (PX) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45971:SF2">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH UVRAG AS AUTOPHAGY ENHANCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21054">
        <property type="entry name" value="RUBC_PIKBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01175">
        <property type="entry name" value="DUF4206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="3">
        <location>
            <begin position="222"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="434" mass="50306" checksum="E725435A4B2D1083" modified="2019-02-13" version="1">VSPVSVCVQENAHFIVVDMVLEMLENAKWTLSLDQWRSTMDTNCLMCKERHKSSAQESSPQKQTFRLHRHKVKYSRVDPRRERYKRRHLDEDMKMSHRETHPCVEQQTQDKAEEEAGKDEPKHQMKTLSVLSTDKMTTSILCSSCSYQLPGTENVAVSSDSLTEEIRQRTRMRGSLSWAPPRFQIIFTVQPTHRRSEVVASQHFLCAGCGTEVEPRYIKKLRYCEYLGRYFCDCCHSGSEAVIPGRVLSCWDFGRYPVSDFSKQLLDSVWQQPLFDLTCVGKNLYSKVKELDRFREVQDQLLGIKKLLKACRLSQSVLAELEHLPAHLREQSNLFSMDDLQKVKKGQLVPQAKAVLQSAITHVENCELCLARGFICEFCREKDIIFPFQTDICKRCPECKACFHKKCFVVKKCPKCARIQSRKDRRNESMKSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZS6</accession>
    <name>A0A3P9CZS6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZS6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027604"/>
    <dbReference type="Ensembl" id="ENSMZET00005028482.1">
        <property type="protein sequence ID" value="ENSMZEP00005027604.1"/>
        <property type="gene ID" value="ENSMZEG00005020588.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286992"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF62">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="37"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="333" mass="37791" checksum="5108A69CDCF4F9FF" modified="2019-02-13" version="1">MFSVSIAEAAALSCGRKVVGACRGGNPRTKWWTPEVKGATRLVLLGKTGSGKSHLGNNILGEELFATYDSPNSGTMKCQTETKTVSGRSITLIDTPGFFDTGRSEEDLKPEIMSCMTECAPGPHAFLIVLRVGKFTEHEQAVVTKIVQSFSDEALKYAVVVFTHGDQLKKNMKIEDFVSQNKNLSDLVSKCDGRCHVFDNEHWNNNQPNNYRSNQFQLEELLKTIEKMVVEKNGGYYTNKMLQHVETAIQEQVEHIRHSITYDWFFCTFYILHLYLLLKLAPREWHSNFVVLCTMTIKAILFYSILYASLHIYCATLQYCDFLHILSVHCVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3Q6</accession>
    <name>A0A3P9D3Q6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <reaction evidence="10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
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            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
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    <comment type="cofactor">
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00180">
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
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    <keyword evidence="9 10 13" id="KW-0464">Manganese</keyword>
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        <location>
            <begin position="50"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
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        <location>
            <position position="123"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="135"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
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    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
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        <ligand>
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    </feature>
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        <location>
            <position position="173"/>
        </location>
        <ligand>
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    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
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        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="350"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="452" mass="50464" checksum="246D37464886C14C" modified="2019-02-13" version="1">MAGYLKVLSSLSRSAGAAFSRNPAVLAPAANCQTLQQRNYADKRIKVANPVVEMDGDEMTRIIWEFIKEKLILTNVDVELKYFDLGLPYRDQTDDQVTIDSALATKKYSVAVKCATITPDEARVEEFSLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQPITIGRHAFGDQYRATDFVVDQPGKFKIIFSPADGSSNKEWEVFDFPAGGCGMGMYNTDESITGFAHSCFQYAIGKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFAQTLEQVCVATVESGTMTKDLAGCIHGLSNVKLNEHYVNTTDFLDAIKTNLDKALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D5P4</accession>
    <name>A0A3P9D5P4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D5P4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029995"/>
    <dbReference type="Ensembl" id="ENSMZET00005030939.1">
        <property type="protein sequence ID" value="ENSMZEP00005029995.1"/>
        <property type="gene ID" value="ENSMZEG00005022366.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234537"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057667">
        <property type="entry name" value="HTH_SB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF135">
        <property type="entry name" value="SI:DKEY-77F5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25787">
        <property type="entry name" value="HTH_SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sleeping Beauty transposase HTH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="149"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38926" checksum="2392E265EA48015D" modified="2019-02-13" version="1">MAKTKELSKDTRKSIVDLHQTGKSESTIGKQLGVKKSTVGAIIRKWKTYKTTDNLPRSGAPRKISSRGVKMIMRTVSKDPRTTRGDLVNDLQRAGTKVTKVTISNTLQWQGIKSRSARHVPLLKPVHVQACLKFAREHMDDTAEDWENVMWSDETKVELFGINSTRRVWRTKNTELHPKNTIPTVKHGGGNIMLWGCFSAKGTGRLIRVKNRMNGAMYREILSQNLLPSVRTLKMKRGWVFQHDNDPKHTARATKEWLRKKHLKVLEWPSQSPDLNPIENLWRELKVRVALRQPQNITALEKICMEEWAKIPATVCANLVKTYSKRLTSVIANKGYVTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6P2</accession>
    <name>A0A3P9D6P2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="4">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6P2"/>
    <dbReference type="Ensembl" id="ENSMZET00005030764.1">
        <property type="protein sequence ID" value="ENSMZEP00005029827.1"/>
        <property type="gene ID" value="ENSMZEG00005022228.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047417"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0835">Urea cycle</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="8">
        <location>
            <begin position="162"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="321" mass="36292" checksum="31ECB88B2C42AA82" modified="2019-02-13" version="1">MEVKEAPQNTLLLSLRSGTLAGAACLGSVNLKGRSCLTLKDFSSDEIKKLLWVSGDLKHRIKHEKQYLPLLQGKSIAMIFEKRSTRTRMSTETGFSLLGGHPCFLTSQDIHLEVLSGFCDVVWLVYTSFNPIINGLSDLYHPIQILADFLTYRSITDPLMSTVSWIGDGNNVLHSFMMTAAKLGVHLKVATPKGYEPDKGVTEEAHRLAKQAARDSNVLVTDTWVSMGQEEEEKEAKRLPWIPDFYAGKKDITFSQTGSVAKSDWTFLHCLPRKMGRWMIRCSTHPFSRFSEAENRKWTSWWGLIVSLLTDYTPQIPMLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6W5</accession>
    <name>A0A3P9D6W5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative ferric-chelate reductase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FRRS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6W5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030089"/>
    <dbReference type="Ensembl" id="ENSMZET00005031036.1">
        <property type="protein sequence ID" value="ENSMZEP00005030089.1"/>
        <property type="gene ID" value="ENSMZEG00005022436.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164178"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900449">
        <property type="term" value="P:regulation of glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09628">
        <property type="entry name" value="DOMON_SDR_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042789">
        <property type="entry name" value="FRRS1L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46902:SF1">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN FRRS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="228"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="309"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="535" mass="57900" checksum="4844356832A5EE29" modified="2019-02-13" version="1">MLSKQKYRASHPDSPAVLHPLVGSTVILCFAVFLTTERSRLENTFVAMALPVLLLLCTAPLVRGHGSGVVIDSCEDMELHHSGLSPQTAPSPFTVTTEQRPSTPFTGFLLEARELGSKSPVGSFAIPEGAAQLLTCSQRAVSILEVNLSSMFMYWNLSLASFVQNSTTFWINVTSPVLTFTNGRAARSAGALTTSTDNGTGPISSADCGVTKVCFSQPSNCDPAVSASCYFISAKMLAGGEAVHFEMTGPYEGYIAFGFSDDQRMGNDDIYVCVMKSNGQVEVEHMYSTGRSKPQVLPLGNVYNITTSLQNSVISCVFTTTNTISIEGTSGFNQWFVTPNKSRISIFNCVSGSLMLIAWMTTGSLGMMVARYLKKMAKGKKMCDKDLWFMVHVGAMCLTVAATIIAFILVFVHSQDWSGGAHPVLGCLVMILSLIQPIGALLRCGPQHHLRYLFNWTHFLNAVVIKSIAVAAIFTGLDRIDSDDGWLLKVMGGFFAWEVLFIIILEVKGDSCLIAVYLLGNLCFLVALLVGIGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8Q4</accession>
    <name>A0A3P9D8Q4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UDP-glucuronosyltransferase 2A1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8Q4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031090"/>
    <dbReference type="Ensembl" id="ENSMZET00005032092.1">
        <property type="protein sequence ID" value="ENSMZEP00005031090.1"/>
        <property type="gene ID" value="ENSMZEG00005023182.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153212"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000001">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF162">
        <property type="entry name" value="UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="558" mass="62580" checksum="FBDF73855B30DEA3" modified="2019-02-13" version="1">MQFQSDWICSQTQDLFVVSHMMQVSTSLPLLLLSLTLLLLHPVSLVHGGHVLAFPGEFSHWLNMRNIIEELVKRNHSVTILVPDASPSVNYNNSRDTAKFNFLVFKVSYSREEYVGTMHEFIQFSMYESHTSSPLQKIMKMNDFMGRTLDFGRQQCDGVLKNQQLMATLQDSAFDAILQDPLAMCGDLVADMLGVPLILSLRFSFGSVMERHCGHAPLPPSYVPLAPLPYNDRMTFVERLINMVTYVASSTLTELAWKLSVNKYYSEIKGTPSSVCETMGKADVWLIRTFWDIETPRPTPPNFKYVGGLHCKPANQLPEDLEAFVQSSGDAGIIVASFGSMVTNLTMQHANIIATAFGQIPQKVIWRYRGEAPTALAPNTKISDWIPQNDLLGHPKTKAFVTHGGTNGLYEAVFHGVPLVGVPLFGDQPDNLARMSRLGTAIVLDFNHLTAEELAEALHVVTNQPSYRTNMQRLSAVHRDQPVTPLSTAVFWVEFVMRHGGARHLRLASYDLNWFQYHSLDTGAALLVALMTIAALWWVGIRCILRQCRQRAGREKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9U4</accession>
    <name>A0A3P9D9U4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Protein phosphatase 1B</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Protein phosphatase 2C isoform beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Monomer. Interacts with PAK6. Interacts with the phosphorylated form of IKBKB/IKKB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 24">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004573384.1">
        <property type="nucleotide sequence ID" value="XM_004573327.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9U4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031129"/>
    <dbReference type="Ensembl" id="ENSMZET00005032131.1">
        <property type="protein sequence ID" value="ENSMZEP00005031129.1"/>
        <property type="gene ID" value="ENSMZEG00005023211.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478948"/>
    <dbReference type="CTD" id="564875"/>
    <dbReference type="GeneTree" id="ENSGT00940000164695"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.430:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.430">
        <property type="entry name" value="Phosphatase 2C, C-terminal domain suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012911">
        <property type="entry name" value="PP2C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036580">
        <property type="entry name" value="PP2C_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07830">
        <property type="entry name" value="PP2C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81601">
        <property type="entry name" value="Protein serine/threonine phosphatase 2C, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="18" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 24" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="26">
        <location>
            <begin position="76"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00065584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00070216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="430" mass="47022" checksum="137259DD7B94E0BA" modified="2019-02-13" version="1">MRTARKGSVEMPAFVRQLVKETEKRVSSFFKGGRGGTAEGEQQGEGEKEEVIPSPYLDRPVLDKLTEEGCARWGLTYALGSMQGWRANMEDFHNCVPQLGGELADWSFFAVFDGHAGSTVAQYCSQHLLGHILATDGIGPEDDPPKVKGAIEEGFLQTDKHLHSVARREGWERGGTTVVATLISPYYIYFANCGDSRAMLCRSGQVCFSTEDHKPYSPLEKERIESAGGSVSLQRINGSLAVSRALGDFGYKGAENRTPSQQMVSPEPEVCVVERSPADEFLVLACDGVWDTISNEELCAFIHNRLRVCTDLRDVCTQVIDLCLYKGSLDNISIILLCFPGAPQLSTEALHQEAELEDLLESKVAEIYDELCVRGEEPELLSVLTVLASTVIPGLPPGGGIQSKRNCIISAYYQQRDAHKPMIPNGLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DB64</accession>
    <name>A0A3P9DB64_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized LOC101480464</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004546068.1">
        <property type="nucleotide sequence ID" value="XM_004546011.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004546069.1">
        <property type="nucleotide sequence ID" value="XM_004546012.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004546070.1">
        <property type="nucleotide sequence ID" value="XM_004546013.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DB64"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031619"/>
    <dbReference type="Ensembl" id="ENSMZET00005032649.1">
        <property type="protein sequence ID" value="ENSMZEP00005031619.1"/>
        <property type="gene ID" value="ENSMZEG00005023587.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480464"/>
    <dbReference type="KEGG" id="mze:101480464"/>
    <dbReference type="GeneTree" id="ENSGT00940000168127"/>
    <dbReference type="OrthoDB" id="9939965at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050868">
        <property type="term" value="P:negative regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026072">
        <property type="entry name" value="Lime1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032748">
        <property type="entry name" value="PAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16322:SF1">
        <property type="entry name" value="LCK-INTERACTING TRANSMEMBRANE ADAPTER 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16322">
        <property type="entry name" value="PHOSPHOPROTEIN ASSOCIATED WITH GLYCOSPHINGOLIPID-ENRICHED MICRODOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15332">
        <property type="entry name" value="LIME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="547" mass="58149" checksum="7C1793D7E7686673" modified="2019-02-13" version="1">MERQGGSQDNLTYQNLLLLGAIAAASAFVVTILIVLVCVGCQRKSKSKHPPAGEKGTSVNMQGTLRHPKLNSMSKSDTRLHEINRFPCNGNSVSKSRPASMDLLLLHSRRSQTDLRPSHGRQLPQIPTSPQRSGQGGEGETGGEGGGGGGGGEARDHTYTEVGLRNNPTPTHYLDDGLYESVGVREGPKVPSAPPTTSANAPAIARAPQSPSTHASGARSGNGHANGGRGNDTINGPMTGRGNGASGVSRSPLSSVNSLAVQDPSLAEYASIRKFRKADKINRKENNGADSQSDSQSSVSDSPSAGPPPLHRSQEFPRKQLEPFHLHSFPKEAVFMGNGEQYIWKPPEDNDIITLHPPPHHPPGENEQGHPSPPTAKEIADTYSIVCKTQKKKPPMEHNGAKTLPRSFGGDRGNMGSRGRGRGVQSQARSQEEPCYEPVGDRSWSSPVAESDPAYATIDPHRKREQGGTNNSTAGGSATLKRKKQQQQQQQATPAAPQASGPSTLPTRGLPGGENFYETISDVKQGGNSTTTIFTFNDGMEMYVTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DD66</accession>
    <name>A0A3P9DD66_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cathepsin Z</fullName>
            <ecNumber evidence="3">3.4.18.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.</text>
            <dbReference type="EC" id="3.4.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.18.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_014268632.1">
        <property type="nucleotide sequence ID" value="XM_014413146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DD66"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032630"/>
    <dbReference type="Ensembl" id="ENSMZET00005033688.1">
        <property type="protein sequence ID" value="ENSMZEP00005032630.1"/>
        <property type="gene ID" value="ENSMZEG00005024313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465864"/>
    <dbReference type="KEGG" id="mze:101465864"/>
    <dbReference type="GeneTree" id="ENSGT00940000155569"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02698">
        <property type="entry name" value="Peptidase_C1A_CathepsinX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000060">
        <property type="entry name" value="Cathepsin Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033157">
        <property type="entry name" value="CTSZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018672319" description="Cathepsin Z" evidence="13">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="14">
        <location>
            <begin position="55"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="298" mass="33078" checksum="7564D22CB2C3EDF2" modified="2019-02-13" version="1">MAATNFACLLFCLASFSQQFSASRLLTEPCYKPIRDHRPDFVRTQARPHVEVLKLPPSWDWRNIDGKNYVSVTRNQHIPQYCGSCWAMGATSALADRINVKRGGAWPSAYLSVQNVIDCGRAGSCYGGDHLRVYAYAHESGIPDETCNNYQAKNQKCELFNQCGTCSFFESCAVVKNYTAWKVGDYGEVSGRDEMKAEIFTGGPISCALMATEGLERYSGGIFSEFHPLSLPNHIVSVAGWGVGEDGIEYWIVRNSWGEFWGEHGWARIVTSAFKGGKGNWFNLGIEKNCAYGDPIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDB7</accession>
    <name>A0A3P9DDB7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase 8 family, member A1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DDB7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032146"/>
    <dbReference type="Ensembl" id="ENSMZET00005033184.1">
        <property type="protein sequence ID" value="ENSMZEP00005032146.1"/>
        <property type="gene ID" value="ENSMZEG00005023126.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156799"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001758">
        <property type="term" value="F:retinal dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042573">
        <property type="term" value="P:retinoic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="139"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="382"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="461" mass="50739" checksum="3B46A39E865263E3" modified="2019-02-13" version="1">MSKTSEERSLLVLENYIGGKFVSCRSYIDSYDPSTGEVYCKVPDSGKEEVDAAVAAAKEILHKLADLIEANLEEFAQAESKDQGKTITAARTVDIPGQRYNFRFFSTSMLHHTTDCSPMDHMGCLNYTIRCPVGTGLISNTVVAKPSEMTSVTAWMLCKLMQQAGVPPGVVNIVFGSGPRAGDALVSHPEVPLVSFTGSTATAQRITERSAPYCKKLSLELGDLDQCIETTVRSSFLNQVKTKCEVCLCTSRIYVERSIYSEFLERFVAAAKKWKTGVPLTPAAKMERSSVRSYIALAKSEGGIIHCGEGSTSWTSRSATSLDTSCRRRSSQAYLTAPVSCRRRSLVPSPVSAPLILRMKLLPGAMVYVTVCQPQCGPRMWEVHRVAQRLQAGLVWTNCWLVRDLNLPFGGMKNSGGEGRRKRFLSLLHRGEDLFLIFTFNDVIVLIKSVTRSVKNAAFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEF4</accession>
    <name>A0A3P9DEF4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zgc:85932</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024660768.1">
        <property type="nucleotide sequence ID" value="XM_024805000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DEF4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033070"/>
    <dbReference type="Ensembl" id="ENSMZET00005034166.1">
        <property type="protein sequence ID" value="ENSMZEP00005033070.1"/>
        <property type="gene ID" value="ENSMZEG00005024659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471759"/>
    <dbReference type="KEGG" id="mze:101471759"/>
    <dbReference type="GeneTree" id="ENSGT00940000165978"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000011">
        <property type="entry name" value="Calpain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000114">
        <property type="entry name" value="Calpain a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000530">
        <property type="entry name" value="Zgc:85932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF434">
        <property type="entry name" value="CALPAIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="10">
        <location>
            <begin position="61"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 8">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="703" mass="79493" checksum="9067343E47B413EA" modified="2019-02-13" version="1">MFAMRKSLSVSSDSSLPPPEDDVDSVCSDELMGSQSRRWLAEILSGGIPPESGEVSPASGLFVDFNFPMGELEMQPGVKWKRPKELCSSPQFIVDGATRLDVRQGKLSDCWLLSAIASLSMNQSLLKKVVPLGQSFQDGYSGCFTFRFWQYGQWEEVRIDDLLPTVDNNLIFLSSPERQEFWSALLEKAYAKLKGGYRALDMGFPHEAMVDMTGGMTEVLQVASLPRDLPTFLRHLLVRGALINCANCQGPLEHRNELGIMFRHAYALTAVDKVRTTLGTEYLVRILNPWGNTEWEGPWSDFKGQEWKTVSIEEQKRLGRVRQEDGEFWMSVSDFRQNFEVMEVCHLTEALGEPGSSMLPLSCIMHHGNWAPNITAGGSPQGGWFYQNPQFYFVLSKADQNPDSAQKTCSFVLALMQKHQRRRGISLAIGLHVYPAHPKNTYLSREDLSVLRPVLHSPQYVARREVVLRGSLPPGCYIIIPSTAEPNQQGAFLLRVLAEQGNNATPARRPSTEDITSVTELSFPHQAALPSPQAIRQLFQKHCNKKGFCKPLHLYKLLTEAIQGGVLAGSEKYLALEQCKSLVVLMDSQGIAQLNWPEFQSLWDKIRRWTDIFLMHDKDKTQRLEYQEVMPSLKAAGIRVDELVMQLVGLRYTEPDMTISYPGFLYLLMKLESMIHKFQAYDVMGTGAVTISYRQWLHMTMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEN2</accession>
    <name>A0A3P9DEN2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ZZ-type zinc finger-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. Interacts via (ZZ-type zinc finger) with histone H3 in a methylation-independent manner and acetylation on 'Lys-4' (H3K4ac) moderately enhances the interaction.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004555226.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004555284.2">
        <property type="nucleotide sequence ID" value="XM_004555227.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004555285.2">
        <property type="nucleotide sequence ID" value="XM_004555228.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DEN2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032606"/>
    <dbReference type="Ensembl" id="ENSMZET00005033664.1">
        <property type="protein sequence ID" value="ENSMZEP00005032606.1"/>
        <property type="gene ID" value="ENSMZEG00005024295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475754"/>
    <dbReference type="KEGG" id="mze:101475754"/>
    <dbReference type="CTD" id="26009"/>
    <dbReference type="GeneTree" id="ENSGT00390000005307"/>
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        <property type="component" value="LG18"/>
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    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZZ_ZZZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000128">
        <property type="entry name" value="Putative ZZ-type zinc finger-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041981">
        <property type="entry name" value="ZZZ3_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH myb-type" evidence="19">
        <location>
            <begin position="833"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="17">
        <location>
            <begin position="833"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="18">
        <location>
            <begin position="1003"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="479"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="789"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="1088" mass="121691" checksum="F55F1A717A38FB34" modified="2019-02-13" version="1">MAASRSSRVTRSSVGLNGLDENFCGRTLRNRSIAQPEETSVSPLPRARSPKKKQDTKQESKHDAKQESKQDNKQDTKLESKHDAKQESKQDNKQDTKPESKQDNKQDTKPESKQDVTQDVKLESKQDNKQDTKPESKQDITQDVKPESKQVPRQDTKPESKQVAKQDVKPESKQVTKQDVKPESKNETKQESNQDVKQESKQDAKQETKHDETPDTYSQDGQQQALLQGNVTHSDASLVEADQWTSSRKRGQSCLEKDISPEKSENCDGGNGARDASPQIKRAKRCSRSGESQGQEKDPELVKPESPDSVPELSKDNSCEELPSQNFANTVPASPILSKQEGGLTGDDAEDGHVECDGASQFPNAHKASNGLRENNTEESNTLGEKSSSNPTPDTNFSSLLNGSQTGTPSSPDPAVPCRNSVPGHMEVSGSGELPSSSAPISEGVLDDSVPELIVAKEQEVEEMEVDVVGDSFCLAHEEQVMDSESDTNGRLLTPVQESVASTSFSTTNMNSSPIHNNNSNSGETTSPLTTPPSPTEPECNPSISSTSTSFTELYEHRYTRRTSPRRAVSSGKACSSKPSSPPRDNGPLREEGEVVVGLEEEDCPMVEEPAPSDSIGHSNEEPVSGDPGDRAGGEDGGFIEGKEAEHSKELTQSQAVEEEEEEEEEEEEEEPDVYYFESDHLALKHNKDYQRLLQTIGVLEAQRTQAILDLETLARHQREALADPISFVEQLQKRVNLGLPCPQHVVQLPDIAWEQYTSGLGDFEREFCDKKRKTRRLKLIFDKGLPLRPKSPVEPKKEGESSTMYSPLPTSDAPENGRQTQMIRGRICHPNKPDTFNQLWTVEEQRKLEQLLVKFPPEEVESRRWQKIADELGNRTAKQVASRVQKYFIKLTKAGIPVPGRTPNLCMYTKKASSKRQHHLNKHLYRPSTFLTSYEPPVYMDEDDERSAYYNSVQDPSADDSDEESVPVELRSLPEYKELLQLKRLKKQKLQEIQEDKTEIRHIGYKCDVCGMEPILGVRWHCQDCPPDNSVDFCSNCSDCLFKTETHKPNHHLEPVYQAETFLDRDYCLPQSTGYNYLDPNYFPANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DER9</accession>
    <name>A0A3P9DER9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004569702.1">
        <property type="nucleotide sequence ID" value="XM_004569645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DER9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032864"/>
    <dbReference type="Ensembl" id="ENSMZET00005033924.1">
        <property type="protein sequence ID" value="ENSMZEP00005032864.1"/>
        <property type="gene ID" value="ENSMZEG00005024470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469159"/>
    <dbReference type="KEGG" id="mze:101469159"/>
    <dbReference type="GeneTree" id="ENSGT00940000156536"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="C2_Calpain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000003">
        <property type="entry name" value="Calpain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000027">
        <property type="entry name" value="Calpain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000173">
        <property type="entry name" value="Calpain 5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033884">
        <property type="entry name" value="C2_Calpain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF402">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="496"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50004"/>
        </source>
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            <dbReference type="PROSITE" id="PS50203"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="637" mass="72572" checksum="403EDFE6B219CABD" modified="2019-02-13" version="1">MAVPYEGQSFSALRRQCQHKGTLFEDPLFPTSDQSLFYQRNQIGRVTWKRPNELTSDPHLFVDGISAHDLHQGQLGNCWFVAACSSLASREALWQKVIPDWKDQEWDKDKPNSYAGIFHFRFWRFGEWVDVVIDDRLPTVNGQLVYCHSNDSNEFWSALVEKAYAKMYGCYEALDGGNTADALVDFTGGVSEPMDLIENGYKQDEEKQHELFERVLKVHNRGGLISCSIRATTQADMEARLDCGLVKGHAYAVTDVRKVRLGHGLLAYFRSDKLNMIRMRNPWGKREWNGPWSDSSEEWQKVSKSEREKMGVTVEDDGEFWMTFDDFIANFTDLILCRLINTSYLSLHKTWEEAVMRGSWHRHDDPLLNRAGGCTNNKHSFLQNPQYVFDVKKPEDEVLICLQQKDRRATLRGGRGENLAIGFDIHKVELNRTYRMHVTQQKVGGSIYINSRSVFLRIDLKEGRYVIIPTTFDPGLEGDFLLRVFTDVTSDCKELTLDEPQKTCWSGMCGYPSLVTQVHILQADGLAAQDSDGASDPYVIIRCEGQKVCSPVYKNTCSPVFDTKGLFYRKKANQPIGIEIYNNNVLKDSFLGQVTLPAEQGEIKKTFHLKDKGDRRDNDLSGTITVAILTSSILTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGR7</accession>
    <name>A0A3P9DGR7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGR7"/>
    <dbReference type="Ensembl" id="ENSMZET00005034486.1">
        <property type="protein sequence ID" value="ENSMZEP00005033357.1"/>
        <property type="gene ID" value="ENSMZEG00005024896.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162312"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16040">
        <property type="entry name" value="SPRY_PRY_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Si:dkey-191j3.2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
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        <property type="entry name" value="Butyrophylin_SPRY"/>
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    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="NLR"/>
    </dbReference>
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        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13516">
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        <property type="entry name" value="BUTYPHLNCDUF"/>
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    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="121"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="313" mass="34678" checksum="BB657F88D41FA0CB" modified="2019-02-13" version="1">HGHPSQFVFIVPCNVLGGCNLSERSCEALCSVLSSQSSSLRELDLSNSDLQDSGVKLLSAGLKSSQCAVETLSLSGCLITEEGCTSLASALTSNPSHLRQLDLSYNHPGPSGVKLLSAGLKDPGWRLDTLRLRIISYSCQLTIDTNTVNTELQLSDNNRKVTRVEEVQSYPDHPDRFDYWAQLLCRNGLTGRCYWEVEWRGRVDISVSYRSIRRKGGSDDCWFGHNDQSWSLSCSDDGPRFLWHNNSRTSISSSSSSVSNRAAVYVDCPAGTLSFYRVSSDTLIHLHTFNTTFTQTLYPGFWFMYPGASLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHY5</accession>
    <name>A0A3P9DHY5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHY5"/>
    <dbReference type="Ensembl" id="ENSMZET00005035550.1">
        <property type="protein sequence ID" value="ENSMZEP00005034345.1"/>
        <property type="gene ID" value="ENSMZEG00005025670.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000193381"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Znf_B-box"/>
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        <property type="entry name" value="Znf_C3HC4_RING-type"/>
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    </dbReference>
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        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="50"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="11">
        <location>
            <begin position="602"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="496"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="797" mass="92178" checksum="5A02A71EDFA11589" modified="2019-02-13" version="1">ASGDFHEFKTGAPGRLELGRAGFRTRATGLTRPVCQRGLGSTMTNVTCHCSVQRLDPVILSCSHSFCRFCLQTWWRKNLKHNCPLCKKTNLSNDPPRNLVLKNLCEAFLLQRDKKASAVSEPLCRLHHETLRLFCLDHQQPVCVVCRDSKAHQDHRFNPTEEAAQDHREELQKHLKPLQDKMKVFEQVKGKFDQTAKHIKVQAQQTEKQIKEEFKKLLQFLQNEEKARLAALRTEEKKKSQMMKKKTEDLNRKMETLSETIRATEEQLRAEDVSFLHNYKAAVNRVKQRPLMDAPQLVSGALIDVAKHLGNLTYNIWNKMKEKMVSYTPVILDPNTAHPQLILSDDLTNPVILSCSHSFCRLCLQTWWTERDIKTCPLCKKTNLSNDPPRNLVLKNLCEAFLLQRDKKPSAVSEPLCRLHHEKLKLFCLDHQQPVCVICRDSKAHKDHRFNPTEEAAQDHREELQKHLKPLQDKMKVFEQVKGKFDQTAEHIKVQAQQTEKQIKEEFKKLQQFLQNEEKARLAALRTEEKKKSQMMKKKTEDLNRKMETLSETIRATEEQLRAEDVSFLHNYKAAVNRVKQRPLLDAPQLDSGALMDVAKHLGNLTYNIWNKMKKMVSYTPVILDPNTAHPQLILSDDLTSVTFGGRQKVPDNPERCHCCKVVLGSEGFDSGTHIWDVEVGEEGFWAFGVVNESYERKVQALSGYWQLCFHDEKYIVTTVPGTYEVLSVKKLQRVRVQLEYDRGKLSFFDLDANTLIHTFEHNFTEKLFPYLLTEKKPLKILPKGTNTDWILGNILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJ51</accession>
    <name>A0A3P9DJ51_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJ51"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034418"/>
    <dbReference type="Ensembl" id="ENSMZET00005035628.1">
        <property type="protein sequence ID" value="ENSMZEP00005034418.1"/>
        <property type="gene ID" value="ENSMZEG00005025717.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177079"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097169">
        <property type="term" value="C:AIM2 inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072557">
        <property type="term" value="C:IPAF inflammasome complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072559">
        <property type="term" value="C:NLRP3 inflammasome complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARD"/>
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        <property type="entry name" value="DEATH-like_dom_sf"/>
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        <property type="entry name" value="Pept_C14"/>
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    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CASPASE-1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEATH domain"/>
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    </dbReference>
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        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="103" mass="11823" checksum="65CD4645480503E8" modified="2019-02-13" version="1">MEELARVRLAFVWRVTTEILTQLLEALVCDTVLNELEKESILEKNLARADKARSLIDTVRKKGDKACKITIKHLQIKDPSLFSQLRLYSDPSAQQGEVMYHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DND4</accession>
    <name>A0A3P9DND4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DND4"/>
    <dbReference type="Ensembl" id="ENSMZET00005037220.1">
        <property type="protein sequence ID" value="ENSMZEP00005035954.1"/>
        <property type="gene ID" value="ENSMZEG00005026833.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263473"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER K-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="56"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="187" mass="21365" checksum="D11D96C2DFB5A30D" modified="2019-02-13" version="1">LFTVFAGLCAVASKHHYQFVRIFNLTRSLEQNRSCSVLLLMFQQRPNSLEYGLFSGSTRTFVFINIITSWANARSYCRLHYTDLASVRSMTENQKIDNLVPLGIRVWIGLFRESWKWMDGSNSSFTYWKTNEPNGPEPCVAANFEENAKWEDWNCESQKDLASVSLPQGSCGYNCSLSPPVCECESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNX8</accession>
    <name>A0A3P9DNX8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545297.1">
        <property type="nucleotide sequence ID" value="XM_004545240.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNX8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035988"/>
    <dbReference type="Ensembl" id="ENSMZET00005037254.1">
        <property type="protein sequence ID" value="ENSMZEP00005035988.1"/>
        <property type="gene ID" value="ENSMZEG00005026853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467158"/>
    <dbReference type="KEGG" id="mze:101467158"/>
    <dbReference type="GeneTree" id="ENSGT00950000182858"/>
    <dbReference type="OrthoDB" id="10013941at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005076">
        <property type="entry name" value="Glyco_trans_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10462:SF51">
        <property type="entry name" value="GLOBOSIDE ALPHA-1,3-N-ACETYLGALACTOSAMINYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10462">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03414">
        <property type="entry name" value="Glyco_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-galactosamine</name>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>an alpha-L-fucosyl-(1-&gt;2)-beta-D-galactosyl derivative</name>
            <dbReference type="ChEBI" id="CHEBI:140327"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605076-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="352" mass="39901" checksum="472953B8DEAE63B4" modified="2019-02-13" version="1">MALFPFCKASSAGPIRVSRIQLVLCCFLLSLIIYYLHGSRAAARVHPAHPIFHPLEMDRGRKVTDMEVLKGAESQTPAETPWGAPLVWGDSRHSASCRAKFAQREMRIGLLAFVVGTYAQFIRRFLYSAETYFLPGQVVTYYILTDNPRSLDPPVKLGPEREMKVVPIAELPGWERLAHRRMTLLGDAIRKSIDSETDYIFCADVDQEFVAPVRAEILGDLVATLHPELYGMPRNAFPYEDDEGSSAYVEEDEGDFYYTSEFYGGAVSEMYKLALACSLLILQDHADGITARGLEESYLNRYLIDHRPTCVLSPEYSWWDSDLSAQVPVHRLLSLGRQCESYNDKQREEHKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSB7</accession>
    <name>A0A3P9DSB7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Arachidonate 5-lipoxygenase b, tandem duplicate 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="10">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014265353.1">
        <property type="nucleotide sequence ID" value="XM_014409867.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSB7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037168"/>
    <dbReference type="Ensembl" id="ENSMZET00005038469.1">
        <property type="protein sequence ID" value="ENSMZEP00005037168.1"/>
        <property type="gene ID" value="ENSMZEG00005027695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482427"/>
    <dbReference type="KEGG" id="mze:101482427"/>
    <dbReference type="CTD" id="567204"/>
    <dbReference type="GeneTree" id="ENSGT00940000156111"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01753">
        <property type="entry name" value="PLAT_LOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.245.10:FF:000001">
        <property type="entry name" value="Arachidonate 5-lipoxygenase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000002">
        <property type="entry name" value="Arachidonate 5-lipoxygenase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020833">
        <property type="entry name" value="LipOase_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001885">
        <property type="entry name" value="LipOase_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
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        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PLAT_LOX_verte"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00467">
        <property type="entry name" value="MAMLPOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00711">
        <property type="entry name" value="LIPOXYGENASE_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="15">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="16">
        <location>
            <begin position="117"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Essential for stabilizing binding to COTL1" evidence="12">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51393"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="674" mass="77985" checksum="11AFB93EFD18C0AD" modified="2019-02-13" version="1">MPSYTVTIATGNQWFAGTDDYIYITLVGTEGCSERTLLDKPLYNDFERGAVDSYEVRVGENLGDIVLVKIEKKKYWVQDDWYCRYITVKTPSGDYLEFPCFCWLVNDKEVVLRDGRAHLPQDDKTSLVKQHRQKELDGRRKTYRWREWQPGFPMSIDANRHKDLPRDIQFDSEKGVDFILNYSKAIENLFVNQFMHMFQSSWSDFSDFEKIFVRIKNTISEYVMQHWKEDFMFGYQFLNGCNPVLIRKCKKLPDKFPVTHEMVAVSLERELTLEEEIEAGNIYIVDYEVLDGITPNSTDPCTLQYLAAPICLLYKNAQNKIMPIAIQLGQVPGEDNPIFLPTDGQYDWLLAKIWVRSSDFHHHQTITHLLRTHLMTEVFGIAMFRQLPAVHPAFKLLIPHIRFTIAINTKAREQLICECGIFDKANATGGGGHVQMVQRAVKTLTFRSLCFPDLIKSRGVDSKEELPTYFYRDDGYKVWEATKRFVSDVVNIYYTSDESVQGDEEIQAFVKDVCSFGMQDLDYCEFPKSVKTREELIEYLTVIIFTASAQHAAVNFGQYDWCSWIPNAPSTMRKPPPNKKGLANVNLIVESLPDRGRSSWHLGAVWALSQYQENELYLGMYPDEHFTEKPVKDAMAKFRKELAEITSSIKKRNEGKKLPYYNMSPDKIPNSVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSM0</accession>
    <name>A0A3P9DSM0_9CICH</name>
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        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain 2 (stretch responsive muscle)</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="STRING" id="106582.ENSMZEP00005037237"/>
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        <property type="term" value="P:protein K6-linked ubiquitination"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
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        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ANKYRIN"/>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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    <feature type="chain" id="PRO_5018239876" evidence="4">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="145"/>
            <end position="177"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="263" mass="28776" checksum="97227404547C2916" modified="2019-02-13" version="1">MPKGSFSLCVCVCVCGVCVVCVCVCFGGLCVCVCVGMTEEESERECRSGKYTAKYTHTCLSDEPLPLLLLCVCLCGQIEPVDTAEFMNAASECKLDIIDRYLEDGGNPNAHDERTALHRACLEGHAPVVQMLLGKGADINLKDQLGSRAIHWACRGGNLTVVEVLKSHGADLNVRDKLHSTPLHVATRTGHTSIVEYLLSCGALINSRDREGDTALHDAVRLNRYKIVKLLIVAGADTKIKNHVTPHKLSDWCIVFWLSCFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AS03</accession>
    <name>A0A3P9AS03_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Dual specificity mitogen-activated protein kinase kinase 7</fullName>
            <ecNumber evidence="20">2.7.12.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">JNK-activating kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">MAPK/ERK kinase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">c-Jun N-terminal kinase kinase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="20"/>
    <dbReference type="RefSeq" id="XP_004539307.1">
        <property type="nucleotide sequence ID" value="XM_004539250.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AS03"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000393"/>
    <dbReference type="Ensembl" id="ENSMZET00005000452.1">
        <property type="protein sequence ID" value="ENSMZEP00005000393.1"/>
        <property type="gene ID" value="ENSMZEG00005000337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475777"/>
    <dbReference type="CTD" id="5609"/>
    <dbReference type="GeneTree" id="ENSGT00940000158914"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06618">
        <property type="entry name" value="PKc_MKK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000214">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052468">
        <property type="entry name" value="Dual_spec_MAPK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238:SF2">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE HEMIPTEROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47238">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="121"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00073834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00077430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00083185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="423" mass="48117" checksum="9A338BBB4878002E" modified="2019-02-13" version="1">MSSLEQRLSRIEEKLKQENEEARRRIDLNIDMSPQRSRPRPTLQLPLANDGGSRSSSSESSPQHHPYPSRPRHMLTLPTPPYGLQKSLENAEIDQKLQEIMKQTGYLKIDGQRYPAEVTDLFSEGEIGSGTCGQVFKVRFKKTGHVIAVKQMRRTGNKDENKRILMDLDVVLKSHDCPYIIQCYGAIVTNTDVFIAMELMGTCAEKLKKRIQGPIPERILGKMTVAIVKALLYLKEKHGVIHRDVKPSNILLDAKGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEDPPLLPLGMGFSLDFQSFVKDCLTKDHRKRPKYHQLLEHSFIRRYEVLDVDVAGWFQVVMDRTESPRSSQCYSHQHQLHSLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AT85</accession>
    <name>A0A3P9AT85_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ELAV-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RRM elav family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554529.1">
        <property type="nucleotide sequence ID" value="XM_004554472.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004554530.1">
        <property type="nucleotide sequence ID" value="XM_004554473.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AT85"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000891"/>
    <dbReference type="Ensembl" id="ENSMZET00005000968.1">
        <property type="protein sequence ID" value="ENSMZEP00005000891.1"/>
        <property type="gene ID" value="ENSMZEG00005000778.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467705"/>
    <dbReference type="KEGG" id="mze:101467705"/>
    <dbReference type="CTD" id="1993"/>
    <dbReference type="GeneTree" id="ENSGT00940000156823"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12771">
        <property type="entry name" value="RRM1_HuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000006">
        <property type="entry name" value="ELAV-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000005">
        <property type="entry name" value="ELAV-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000017">
        <property type="entry name" value="ELAV-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="154"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="306"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="389" mass="42517" checksum="58A88DE18DAE65BD" modified="2019-02-13" version="1">MAVRLCDVASLLRSGSWAPEPWTGQVIAAMETQLSNGPTCNNTSNGPSTITNNCSSPVESGSVEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYVDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDRRVEAEEAIKGLNCQKPPGATEPITVKFANNPSQKTSQALLSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKSRFSPMAIDGVTSLAGINIPGHAGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAVAIASLNGYRLGDRVLQVSFKTNKTHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AU61</accession>
    <name>A0A3P9AU61_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MPV17 mitochondrial membrane protein like</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AU61"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001255"/>
    <dbReference type="Ensembl" id="ENSMZET00005001344.1">
        <property type="protein sequence ID" value="ENSMZEP00005001255.1"/>
        <property type="gene ID" value="ENSMZEG00005001040.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111088"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF39">
        <property type="entry name" value="MPV17-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="224" mass="26109" checksum="008C171FD1C9B213" modified="2019-02-13" version="1">MRRAVLKEAAKRFPWLANVTLYGCLFAGGDLVHQLIAQKEHMDWKHTRNVAIVAISFQGNFNYFWLRALERRFPGKSAGMVFRKLLLDQSFASPLATSVFYTGVSFLEGKEDVFEDWREKFFNTWKTGLMYWPFMQFLNFVLMPLYMRTAFMGCCAFLWATFLCFSRQNGDGTAGVAFAFIMDPRKTLEEMREAREEEGMEEEAASVIQVVEPWRKDREFVTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AV05</accession>
    <name>A0A3P9AV05_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemokine (C-X-C motif) ligand 14</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
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            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSMZEG00005001209.1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0202">Cytokine</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="23"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001458.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="99" mass="11780" checksum="E0D7C671607B39A7" modified="2019-02-13" version="1">MRGCTTVLLLLVVALCCLSAEAYKCRCTRKGPKIRYKDVQKLEIKPKHPFCQEKMIFVTMENVSRFKGQEYCLHPKLQSTKNLVKWFRIWKDKHRVYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AV56</accession>
    <name>A0A3P9AV56_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MYC</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="bHLHzip_c-Myc"/>
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    </dbReference>
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        <property type="entry name" value="Myc proto-oncogene protein"/>
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        <property type="entry name" value="Tscrpt_reg_Myc"/>
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    </dbReference>
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        <property type="entry name" value="MYC PROTO-ONCOGENE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LEUZIPPRMYC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="199"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="367" mass="41670" checksum="253A15FEE91BEE34" modified="2019-02-13" version="1">MPPVLNSTNYDYDYDVVQPYFFLNGEEEDFYPPPRSQLLPAPSEDIWKKFELLPTPPLSPSRRPSLSAADHLEAVSDLLDDDHSSSAAFLQSFIIQDCMWSSSFAAATELEKVVSERLASLRARRDSCNTKTITDRTADEQVGGSQVSAGYLQDFHTSVTDCIDPSVVFLGEKQMDDGVAMEVGSELRLDSPPPSSSDSESEEDDEEEEEEIDVVTVDRRKSSRRSHTSPLVLKRSHVNIHQHNYAAQQPPEKRVKAESSSAAPRQSGGRRCWSPKSEGEDNDKRRTHNVLERQRRNELKMSFMVLRDEVPAVANNEKAAKVVILKKAAEFIMEVREQERKLLAKKDELRKRSRELKQRLQQLRTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVP4</accession>
    <name>A0A3P9AVP4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin polymerization-promoting protein family member 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPPP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539904.1">
        <property type="nucleotide sequence ID" value="XM_004539847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVP4"/>
    <dbReference type="Ensembl" id="ENSMZET00005001788.1">
        <property type="protein sequence ID" value="ENSMZEP00005001694.1"/>
        <property type="gene ID" value="ENSMZEG00005001390.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470546"/>
    <dbReference type="KEGG" id="mze:101470546"/>
    <dbReference type="CTD" id="51673"/>
    <dbReference type="GeneTree" id="ENSGT00940000153875"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000057">
        <property type="entry name" value="Tubulin polymerization-promoting protein family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF16">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="178" mass="19726" checksum="3CBC1AD2E329F8D2" modified="2019-02-13" version="1">MAESADMEQLLTAFRKFAVHGDTKATGKDLTGKNWAKLCKDCKITDGKNVTGTDVDIVFSKVKQKTSRVINYEEFQKALEELAPKRFKGQSKEEALQSIHKLVEGREPTNVGVTKVAKTAAVDRLTDTSRYTGSHKERFDDSGKGKGREGREEIVENTGYVGAYKNAGTYDTKVKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVU0</accession>
    <name>A0A3P9AVU0_9CICH</name>
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        <submittedName>
            <fullName evidence="10">Leucine rich repeat, Ig-like and transmembrane domains 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVU0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001542"/>
    <dbReference type="Ensembl" id="ENSMZET00005001631.1">
        <property type="protein sequence ID" value="ENSMZEP00005001542.1"/>
        <property type="gene ID" value="ENSMZEG00005001262.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF14">
        <property type="entry name" value="LEUCINE-RICH REPEAT, IMMUNOGLOBULIN-LIKE DOMAIN AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018031759" evidence="8">
        <location>
            <begin position="23"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="253"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="555" mass="62474" checksum="60E9D61B6A12014F" modified="2019-02-13" version="1">MDAFYVTLHITLVFQFISFGSSTCLFGCSCTDDILGRSLLCMETSMGEIPVDIPHDFIKIRIEKSHLTELPRGSFSKVPALEFLWLNFNEIALMNMKSLERLANLTELRLQGNKLTSVPWTAFQDTPKLKILDLKHNHLDVLPEHALRYLPALTYLDLSFNQLSVIAKEVFINWPLFQIAEKAWAKEGMVSNVVLGLHDNPWLCDCRLKGFVEFTRAVSPPIILMNSYLMCSGPALKAHKFFHEIQLKSCMRPVTSAPETNITLPLGANATLTCLVKGRPEPTIQWMYSLKIIRGFTNIDEETFSSQLLIPSLHLADRGLYTCTANNFIGNSSVNITVNIASSDSSLPLLPPVPMLSSEENAYIEIHIAKQTVYGITLEWHAATENPAETWFTIHFGKYDSPKKEMIYIGPGINSYSVSNLLPVTKYEVCVTLKNHPPREGQCIVFVTGSDISEMEQKERLIHIIVIVCAMVLAVPVGMYACTTEARFSCVDRFVDLWRMHRMHDENLQEGARQGTFDSLQATSDEALCKSSMEKPTKRRRSEDKSKGGSAAYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWF9</accession>
    <name>A0A3P9AWF9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial enolase superfamily member 1</fullName>
            <ecNumber evidence="3">4.2.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-fuconate dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <reaction evidence="1">
            <text>L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:22772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:21291"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:amino acid catabolic process"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
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    <dbReference type="PANTHER" id="PTHR13794">
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
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                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005001791.1"/>
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    <dbReference type="PANTHER" id="PTHR11852:SF4">
        <property type="entry name" value="LITTLE ELONGATION COMPLEX SUBUNIT 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1018"/>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1574" mass="172620" checksum="DC88520813D2C351" modified="2019-02-13" version="1">MMPGENQSKALAIAADATTGNCQNCSVLQQSLAEYVSSFLALKQKIAVSDDTIRLQQQLEELQIRLVTLEKKTADYESVQAELEEKKSALKVYEQLSEEVEKLKVEKSETIAENKKLEDQLKNVKDLADKQTLENAQLKREKAVVENNLLISQTSLQKSQAQAEQAEKLMDENAKMTSTKDSLESKIRILEDSVCQQKHKISQLTKEKTILEKSINDLQVRLMKLERERNKEYRSTTTQASAPAEPKIDKEKFWMLLENLWACVDPEQESSVNQLHFHESRVPPSSPQATLHSHLSKMSPFGSPKISEPHSFHIPAKATCTPLNQSPRAQDAIKHKASLQCSGERKQAGTPKMSKRSPKARKTAESSTEMDTLSVEEIIRLFKPMPPSISPLPDLNTEVESMKMEVRENESHSKPCEDRPALKQEQTLHIATSPSSQRNPKSAALQMEENADLSVVADEREGEISNEKDFEPTKFGDIPKVIDKIATDVRGIRPQNDMLIEQEPSSAQLSPPSSSFSTSSFTGLIEAVPLPTESTLLSCNPGISRISKNENALEDANSDLSETVTSMDVDMSPSDITDNKTVAPDGGESALISDSMEGIVAAATQNSSDIEKNTLDSFKLQDSTRSGCKDSDIPEHTQSSSGSSDSITAVSNEHLEEKLEVDESIKLLGKEDGNAQRTAEDDVAALPASSTCNNIPPPPTSALLKKENDQSGADQESGHANVEPFRKKDADIEIVTSFQETNTINCESLKESAHSLCKRVSPSCLLASIKLQALDSHPGKLNVDVNIDHVSTNKPIPFPYLEKECDIEKATVEDLPQHKVHTSSSTSLETMPDSPETNTVNCKASKEDGHSLCRQLSPSCLLPTVKLASLDTQPNPGILDADVQTEIISTNIQSPSFSLEEQGVTKSATNEDQAQDEMNGGDTTPLIQNPATEGKDKSLDLQTVEPENLIREEKTTSGESSAEAQAPECISNVRGEMGPPLPRLLTPLKTPPKANRSINPRQAIGKLLFPSPMDGIESPTSPTQTNRTPNRHQLSSLSTNSPLPLNGVPSSPLQFGSATPKHAVPVPGRLPLTAVSSSPSSSSTTPSQENSMRFLDTMYPELSARARTLSILRGNVNLNICSSEGRTLPTTDSQKSSFKTINSTSTAFTKTEVRGEKRPAIGMLQPKSSKCLRLDQAAGVTRNQVLASSSKSGDDTSSAQNPTLEQPKTETTSSPLKSVEHPQKNLIVNSLRKIEDQCFDLLPVIRSHLHVGNLPKKPVLRDEEKEVIAEVCQSNSADDMIVAILNKLKAGKMDLSRNYVQALCRVYTGLCRQRRDVEKARVLAYSLLIENFPDSAKLILFMVTTWPNLLTHTSSLSQAIHAVTKLRASEELLSCLLAFLGWNKTPPCDIDELISRTLSEIRSGSNLSFTKHSRYGEDLGAEAWEHVYALHLLCTNKKWKWTYDNLLGKELWPLMNSWVTQPRQQQQPISDVAVATVLRLIGCLGQLGLKEKCNSTVVTIANVINTFGRHGPTEGVPWEVQLAAIYCIYDLSPCNPKQALEALAEWRGETSQSVPPAITSCINQLASICRQANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXK7</accession>
    <name>A0A3P9AXK7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myristoylated alanine-rich C-kinase substrate</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MARCKS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004540386.1">
        <property type="nucleotide sequence ID" value="XM_004540329.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXK7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002421"/>
    <dbReference type="Ensembl" id="ENSMZET00005002531.1">
        <property type="protein sequence ID" value="ENSMZEP00005002421.1"/>
        <property type="gene ID" value="ENSMZEG00005001901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475091"/>
    <dbReference type="KEGG" id="mze:101475091"/>
    <dbReference type="CTD" id="323201"/>
    <dbReference type="GeneTree" id="ENSGT00730000111419"/>
    <dbReference type="OrthoDB" id="9950867at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060027">
        <property type="term" value="P:convergent extension involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003381">
        <property type="term" value="P:epithelial cell morphogenesis involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900144">
        <property type="term" value="P:positive regulation of BMP secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060541">
        <property type="term" value="P:respiratory system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035914">
        <property type="term" value="P:skeletal muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002101">
        <property type="entry name" value="MARCKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14353:SF9">
        <property type="entry name" value="MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14353">
        <property type="entry name" value="MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE MARCKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02063">
        <property type="entry name" value="MARCKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00963">
        <property type="entry name" value="MARCKS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="218" mass="22233" checksum="A017E8E14D863F22" modified="2019-02-13" version="1">MGAQISKTAGKEEAAVEQPAEGAAVAAKTNGQENGHAKTNGDTSPATEEVNKAEVQANGSTPTEEAPKEEGEKVEGAEANGEKEPAATNGEASAKPEEGTPSTSEDGKQKKKRFSFKKPSFKLSGFSFKKTKKESEEATEDGAGAAAEPAEGEKATSEAPTEEAKPDEAGEEAKEAAAEEPKAEEGKAEETAGEEKPAEASPTEPETAASPEAAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXW9</accession>
    <name>A0A3P9AXW9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">MAP/microtubule affinity-regulating kinase 3</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with MAPT/TAU. Interacts with DLG5 (via coiled-coil domain). Interacts with STK3/MST2 and STK4/MST1 in the presence of DLG5. Interacts with YWHAB, YWHAG, YWHAQ and YWHAZ. Interacts with PKP2 (via N-terminus). Interacts with CDC25C. Interacts with KSR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004554775.1">
        <property type="nucleotide sequence ID" value="XM_004554718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXW9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002535"/>
    <dbReference type="Ensembl" id="ENSMZET00005002648.1">
        <property type="protein sequence ID" value="ENSMZEP00005002535.1"/>
        <property type="gene ID" value="ENSMZEG00005001972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465281"/>
    <dbReference type="KEGG" id="mze:101465281"/>
    <dbReference type="CTD" id="334300"/>
    <dbReference type="GeneTree" id="ENSGT00940000154862"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12196">
        <property type="entry name" value="MARK1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14072">
        <property type="entry name" value="STKc_MARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001032">
        <property type="entry name" value="KP78b, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000001">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049508">
        <property type="entry name" value="MARK1-4_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF98">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="54"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="24">
        <location>
            <begin position="324"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="25">
        <location>
            <begin position="764"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="369"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="592"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="689"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00054424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="813" mass="90670" checksum="80EF0D4AA11C6AF4" modified="2019-02-13" version="1">MSTKTPLPTVNEKVTESHTSHSNGRQEISTRSGRTGVRPARSSEEPQQPHVGNYRLLKTIGKGNFAKVKLARHMLTGREVAIKIIDKTQLNPNSLQKLFREVRIMKILNHPNIVKLFEVIETERTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKDRWINAGFDDDELKPYTEPELDITDQKRIDVMVGMGYNLEEIQESLAKMKYDEITATYLLLGRKASELEPGDSASSSNLSLAKPRPSSELNGQSPSHLKVQRSVSSNHKQRRYSEQVGQNLPPGMAHPKRSQTTTAENSVKEEGGVQLRKPSIPGTRGAPPSSPLLGNANNPNKADIPDRRKGATTAPSNNTASAGMTRRNTYVCSDRNNTDRLSVIPNGKENSMTEMACATSPPSAFAAAAFGASSSSVRLRYQTVGPLYACQAGWATLPHSYYALDYCSPNNVAVSPGSQRNPVASTHSVANTTTPDRLRFPRGTASRSTFHGGQLRDRRTATYNGPPASPTLSHDATPLSQTRSRGTSNLFSKLTSKLTRRNMSFRFTKRVSTEFERNGRLEGSSRHVPGDQKGENKDSKPRSLRFTWSMRTTSSMEPCDIMREIRKVLDANNCDYEQQESFLLLCVHGDGRAENLVQWEMEVCKLPRLSLNGVRFKRISGSSIAFKNIASKVANELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AY22</accession>
    <name>A0A3P9AY22_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AY22"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002590"/>
    <dbReference type="Ensembl" id="ENSMZET00005002703.1">
        <property type="protein sequence ID" value="ENSMZEP00005002590.1"/>
        <property type="gene ID" value="ENSMZEG00005002052.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016421"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF23">
        <property type="entry name" value="PROTEIN DOPEY-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="107" mass="12396" checksum="8CAE38958B265251" modified="2019-02-13" version="1">MDPEELELQNDYRYRSYAAVIEKALRNFESSSEWADLISSLGKLNKALQTNLRYSLLPKRLIIGKRLAQCLHPALPSGVHLKALETYEVIFKIIGTKWLAKDLFIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYP4</accession>
    <name>A0A3P9AYP4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosine receptor A2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 14">Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4. Interacts with NECAB2. Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567371.1">
        <property type="nucleotide sequence ID" value="XM_004567314.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004567372.1">
        <property type="nucleotide sequence ID" value="XM_004567315.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYP4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002793"/>
    <dbReference type="Ensembl" id="ENSMZET00005002909.1">
        <property type="protein sequence ID" value="ENSMZEP00005002793.1"/>
        <property type="gene ID" value="ENSMZEG00005002189.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475018"/>
    <dbReference type="KEGG" id="mze:101475018"/>
    <dbReference type="CTD" id="561701"/>
    <dbReference type="GeneTree" id="ENSGT01030000234555"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001609">
        <property type="term" value="F:G protein-coupled adenosine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060047">
        <property type="term" value="P:heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060784">
        <property type="term" value="P:regulation of cell proliferation involved in tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061469">
        <property type="term" value="P:regulation of type B pancreatic cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000061">
        <property type="entry name" value="Adenosine receptor A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001513">
        <property type="entry name" value="Adeno_A2A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001634">
        <property type="entry name" value="Adenosn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF47">
        <property type="entry name" value="ADENOSINE RECEPTOR A2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00553">
        <property type="entry name" value="ADENOSINA2AR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00424">
        <property type="entry name" value="ADENOSINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="21"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU201114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="444" mass="49331" checksum="56D24FF4FAD6316A" modified="2019-02-13" version="1">MRDKFFYITLELLIAIFSVLGNVLVCWAVALNSNLQSITNFFVVSLAVADIAVGVLAIPFAIVISIGFCSNFYGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIKIPLRYNSLVTGQRARGIIAICWILSIIIGLTPMMGWHGGESRNGTNETKSSPCQPGMMKCLFEDVVNMKYMVYFNFFACVLIPLLLMLAIYLCIFMAARHQLMLIEVKASHGEKSRSVLQKEVQAAKSLAIIVGLFAVCWLPLHIINCFTLFCPQCDRPPALVMYVAIILSHANSVVNPFIYAYRIREFRHTFRRIIRRHILGKREVFESSGSKRNSTHNSITDSIRLKANGLSFDLFTEHSSSTCENSCRCPAHISPLEGGLATVSHPPLSVVIAHCPKVGTCPLQALRQTQLPAGNDCSEPEILEENCRQNLAPAQVALLFNTQDRKSCCSELDKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0G4</accession>
    <name>A0A3P9B0G4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Olfactory receptor C family, u1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0G4"/>
    <dbReference type="Ensembl" id="ENSMZET00005003545.1">
        <property type="protein sequence ID" value="ENSMZEP00005003413.1"/>
        <property type="gene ID" value="ENSMZEG00005002608.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166814"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vomeronasal 2, receptor 120"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF579">
        <property type="entry name" value="OLFACTORY RECEPTOR C FAMILY, U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="650"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="727"/>
            <end position="750"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="770"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="804"/>
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        <location>
            <begin position="836"/>
            <end position="860"/>
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    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
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            <end position="874"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="876" mass="97716" checksum="F12812A2226E758E" modified="2019-02-13" version="1">MLYLFCNPVYIVFSDVSHTVDEGKPLRVEGHSIRKEEVMRETQHSLKIGDVRSSKSSLPDCVKLAGSEPLALHSDGDIVIGGFFTLHYVVPKPQQSYNSEPQIPPCSGFHERSFRWMMTMVFAVEEINHNSSLLPGVKLGYRIMDSCNYIHNSLQALYSLQSSTCLYYSPVPAVIGLASSSPTRAVAQTLGPFNIPLVSYFATCTCLSDKHLYPSFLRTVPSDLFQVRGLVNLVTYFGWFWVGTIGATDDYSLYGIQAFSNQFRRQGGCVAFHLSIPASPTTVEILEMADKLESSTARVVVVITAEVDVLHLFSELAQRNVTGIQWIASEAWVTSSRLASPDFHFLLEGTLGFSFPGVSIPGLKEFLLNVRPSPKPGKEFINMFWEEHYMVGNYAGSLAKPVCTGSEDLRQTDSSYSDVSPVRISYNVYKAVYAVAHALHTFLNCDSVGHNKGLCEKHRSFSNGQFLQHLKMVNFTNQFNEKVYFDSNGEPVPLYDIINWQKDTRFIKVGNYDGSAPHGQQLQIMKNTIVWTKGERQVPVSQCSAPCPPGSRQATRRGEPKCCFDCLPCADGEISNQTGSTDCIKCPEYYLSDKDKVKCVAGEEEFLSFYDAMGIILVALTLLGFILTSIITIVFHSFRFTPIVKANNSEISFLLLLSLKLCFLCSLVFIGQPSWWTCRLRQAAFGISFALCLSCVLFKTIVVLLAFRTNVPGSRGRMLFGTAQQRILIICTTAPQICLCAGWVLAAPPFPFRNPNYQIVVECKEPWPPGFYLLLGYIGLLAFACLLLAFLGRKLPDTFNEAKLITFSMLIFWAVWISFIPAYVSSPGKFSVAVEIFAILSSSFGLLLCIFIPKCYIILLRPERNIKKGMTGKYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0K4</accession>
    <name>A0A3P9B0K4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)H dehydrogenase, quinone 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0K4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003458"/>
    <dbReference type="Ensembl" id="ENSMZET00005003590.1">
        <property type="protein sequence ID" value="ENSMZEP00005003458.1"/>
        <property type="gene ID" value="ENSMZEG00005002670.1"/>
    </dbReference>
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        <property type="component" value="LG8"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF34">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE [QUINONE] 1 ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like fold" evidence="3">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="244" mass="27051" checksum="3F5C3E25F57A4BB2" modified="2019-02-13" version="1">AAAKDAAVAALTAQGCTVDVSDLYAMKFKAAATTEDITGGVKTAADRYADQIKLAWEEGRIADNIKKEQEKLKEADLVIFQFPMYWSSVPAIMKGWMDRVLGCAYAQEKRYSEGIFKDKKAMLSFTTDCPESVYSDTGINGDINVTLWPLQVRSHYKQSQIFWDPATGSPESRSSMLEGWRTRLQNLCGEATVYFAPLDYFDKEKGFLLKPEVKEKYASNESGLTVGIHMGKPLPANSQTKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B177</accession>
    <name>A0A3P9B177_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide 5'-hydroxyl-kinase Clp1</fullName>
            <ecNumber evidence="7">2.7.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polyadenylation factor Clp1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide kinase Clp1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Pre-mRNA cleavage complex II protein Clp1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CLP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13184"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136416"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-phospho-ribonucleoside-RNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54580"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:15179"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.78" evidence="7"/>
    <dbReference type="RefSeq" id="XP_004545536.1">
        <property type="nucleotide sequence ID" value="XM_004545479.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004545537.1">
        <property type="nucleotide sequence ID" value="XM_004545480.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B177"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003690"/>
    <dbReference type="Ensembl" id="ENSMZET00005003843.1">
        <property type="protein sequence ID" value="ENSMZEP00005003690.1"/>
        <property type="gene ID" value="ENSMZEG00005002850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487618"/>
    <dbReference type="KEGG" id="mze:101487618"/>
    <dbReference type="CTD" id="10978"/>
    <dbReference type="GeneTree" id="ENSGT00940000153668"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051736">
        <property type="term" value="F:ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070922">
        <property type="term" value="P:RISC complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021522">
        <property type="term" value="P:spinal cord motor neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.330:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000454">
        <property type="entry name" value="Protein CLP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="132"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="325"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="441" mass="48857" checksum="417F69C80F29898F" modified="2019-02-13" version="1">MATEGVEKTSEDAPAAGKASTRYDLEKETELRFEVESGEAAEQVELELLTGMAEVFGSELNRNKKYTFGPGSKIAVFTWQGCSVNLYGKPEVAYVSKDTPMLLYLNTHAALEQMRKQAERDNERGPRVMVVGPTDVGKSTVCRLLLSYAVRVGRRPTFVELDVGQSGVSVPGTVSALCIERPADVEEGFSVQAPLVYHFGSTSPGTNIKLYNKLTSCLAEVFSQRCEVNRKASVGGCIINTCGWVKGSGYQALVHCASTFQVDVVLVLDHERLYNELKRDLPHFVRVVLLPKSGGVVERSKECRRDTRDEKIREYFYGFRGVTFYPFSYEVRFSDVRIYKIGAPSIPDSCLPLGMSQDDTQLKLVPVTPGRDLTYHVLSVSSAEDGDEGARKGIVESPVCGFIVVTHVDTQTQVMKVLSPAPRPLPRHTLLIMDIRFMDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2K7</accession>
    <name>A0A3P9B2K7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 4 member 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554837.1">
        <property type="nucleotide sequence ID" value="XM_004554780.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2K7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004131"/>
    <dbReference type="Ensembl" id="ENSMZET00005004302.1">
        <property type="protein sequence ID" value="ENSMZEP00005004131.1"/>
        <property type="gene ID" value="ENSMZEG00005003156.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479451"/>
    <dbReference type="CTD" id="83959"/>
    <dbReference type="GeneTree" id="ENSGT00940000154894"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000002">
        <property type="entry name" value="Solute carrier family 4 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000017">
        <property type="entry name" value="Solute carrier family 4, sodium borate transporter, member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="315"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="849" mass="95761" checksum="0AB5D0CA216C6F2C" modified="2019-02-13" version="1">MKTVKDDGKVRAASVNRFTKEAPPSGMSKNGYFFQEMEQREVEQEEGSEGREEGQDSPIACGDDIHLYDNQISPGPETDDSGCVLLNTSRRYVKLMNFEEEVRAHRDLDGFLARASILLDETAASLDDVLKRMLHHVGQDSHALEPGCNFEEVMSMLFTDAGAQEVNVHLLSETIQGVTATATGVQYQQSWLCILCNVKHLQKRHVCISRLERPQNWGENCCEVRYVILILAPLKMKSTKTAMELGRTFATLFSDISFRQKLLETKTQEEFKEALVFQRHQLTAANQKPTALGKEETDPRSHKPLKCKDFFKAGRGIYEDFCRRLPFYPSDFTDGIVGSNKTLLKYMTTAIFLYIAILLPAIAFGSLNDESTRGEIDVRKTIIGQSIGGVIYSLFAGSPLVIPLTTAPLAIFISVIRGICDDYNLDFPAFYACIGLWNCLFLILGGIFNVSLLMKLFKRSTEEVIALFISIAFVVDAVKGTVKIFHRYYHAPTLANRSIGDFPQGGDLLGGNRSEVVAGFALTESFIQCSRERPVLCLLLMLGTLWMGYTLYQFKRSPFLHAKVREVLSDCALPISVLMFSFIGSYIFSDIELPVFKVHNRPTFNVAPFERLSPMNVVSAMGLGFLLALLIFIDQNIVVSLTNAPENRLLKGTAYHWDLMLSGLINILMSVLGLPWMHAAFPHSTLHVRQLAFVEQRVEGGHLYETIVQVKETRLTSLAANIFIGISVLLLPLPLQWIPKPVLYGLFLYIALTSIDGNQMCDRMALLLKEQTSYPPTHYIRKVPQRKIHYFTFLQMMQLLVLCTFGMYPIPYMKMIFPLVMILLIPIRNNVLPHIIEAKYLDIMDAQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3Q9</accession>
    <name>A0A3P9B3Q9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Interferon a3</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta interferon family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014265825.1">
        <property type="nucleotide sequence ID" value="XM_014410339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3Q9"/>
    <dbReference type="SMR" id="A0A3P9B3Q9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004519"/>
    <dbReference type="Ensembl" id="ENSMZET00005004721.1">
        <property type="protein sequence ID" value="ENSMZEP00005004519.1"/>
        <property type="gene ID" value="ENSMZEG00005003499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105941027"/>
    <dbReference type="KEGG" id="mze:105941027"/>
    <dbReference type="GeneTree" id="ENSGT00510000050089"/>
    <dbReference type="OrthoDB" id="8933852at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000471">
        <property type="entry name" value="Interferon_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691:SF73">
        <property type="entry name" value="INTERFERON BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11691">
        <property type="entry name" value="TYPE I INTERFERON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00143">
        <property type="entry name" value="Interferon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018271318" evidence="9">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="201" mass="22656" checksum="0912F4880A5599C9" modified="2019-02-13" version="1">MVTWGLLFVLCGALTPALCCDWLTHYKQPSKEARGLLTLMGDQLTEQHSSVHPVRFPKHLYKQIKNSEVDSKLVFIRDSLQLIFCLYRHDNLSAAPWGADKTEGFLTVIHRQIMELSACVSTNSPANSRLRSYYRTLANSTLSCSGCSTASWQLLRKETKLRLEQLELLVASIRVPAAASRRRSAATQQQRNTDTISEDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B575</accession>
    <name>A0A3P9B575_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerebellar degeneration-related protein 2a</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDR2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B575"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005043"/>
    <dbReference type="Ensembl" id="ENSMZET00005005267.1">
        <property type="protein sequence ID" value="ENSMZEP00005005043.1"/>
        <property type="gene ID" value="ENSMZEG00005003913.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018570"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026079">
        <property type="entry name" value="CDR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232">
        <property type="entry name" value="CENTROCORTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19232:SF1">
        <property type="entry name" value="CEREBELLAR DEGENERATION-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="205"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="461" mass="53152" checksum="0B46ACCB088E6500" modified="2019-02-13" version="1">MLTDMILEEEFEKNGESWYNQQELEHDLHLAAELGKTLLDRNHDLEQALQQMYSTNQEQLQEIEYLTKQVELLRQMNDQHAKVYEQLDTAARDLEQGNQRLVQDNRMAQHKIQNLTETIEALQTLMEDLQAQVGELKTAEAERNKRELAEQRRSLGAQSVSCLKELYDLHHDRYQANGSHLVDGLWSPYGSFQDRKKQPDPEEENAALQRSIQTLQSQIAAERSRREAAEREMELTARENSTLEQQLVQLSGYQARQKELEAEVEQLQLLWRADCTKRKPDELLVPDTVFFASEDKPCPEQSKPEEKTETVEEQSRYGRQRCNSDSVLKATNPDEILRSHEQLCIRRAEAVKKRGISLLNEVDAQYSALQVKYDELLQRCQQASDELSHKAVQTSSSPFASGRSRRRLSSSAALSDLSVLLEDGQQPEYKALFKEIFTCIQKTKEDLSGNEQPVRDDESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B850</accession>
    <name>A0A3P9B850_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G kinase anchoring protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GKAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547333.1">
        <property type="nucleotide sequence ID" value="XM_004547276.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B850"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006040"/>
    <dbReference type="Ensembl" id="ENSMZET00005006312.1">
        <property type="protein sequence ID" value="ENSMZEP00005006040.1"/>
        <property type="gene ID" value="ENSMZEG00005004690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464579"/>
    <dbReference type="KEGG" id="mze:101464579"/>
    <dbReference type="CTD" id="80318"/>
    <dbReference type="GeneTree" id="ENSGT00390000008742"/>
    <dbReference type="OrthoDB" id="5864420at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026109">
        <property type="entry name" value="GKAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14899">
        <property type="entry name" value="G KINASE ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14899:SF0">
        <property type="entry name" value="G KINASE-ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02083">
        <property type="entry name" value="GKINASEAP1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="384" mass="43019" checksum="708BE3AAF47D3947" modified="2019-02-13" version="1">MASSAMITVPTTASRFALLQIDSDSDSDTSESGKATTKTGRDSSGKPRQGKAGAAGGKAAQGNDKKKDKKKKKKEQQQSEANELRNLAFKKIPQKSSAPSPCMTLSGIAGELLNPTSVDQDTPSEGWQQWKQRDEQITTELYEADLEKALILSKLEYEQQKQSNTNTSSPKSRSGKEGGGKKDKKKNQQAKDKKTVSLQDFQAESSAENLSRKQEKEDSRTANLALGVGQDERFFNKLEDDVSRIIQREKRREQYTNSQGQEVSTSTEHEPDPRAEQLKYELEKKDQEIDKLKKNISQWEVKYKEVKARNAQLLKMLQQGEMKDKAEILLQVEELLHIKEELSSQVTLLHAALEQERSKVKGLQSEQPKHQGNKKGKKGSEADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8A8</accession>
    <name>A0A3P9B8A8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Pyruvate kinase</fullName>
            <ecNumber evidence="5 15">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 15"/>
    <dbReference type="RefSeq" id="XP_004567753.1">
        <property type="nucleotide sequence ID" value="XM_004567696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8A8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006105"/>
    <dbReference type="Ensembl" id="ENSMZET00005006393.1">
        <property type="protein sequence ID" value="ENSMZEP00005006105.1"/>
        <property type="gene ID" value="ENSMZEG00005004739.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478637"/>
    <dbReference type="KEGG" id="mze:101478637"/>
    <dbReference type="CTD" id="445094"/>
    <dbReference type="GeneTree" id="ENSGT00390000008859"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="16">
        <location>
            <begin position="42"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="17">
        <location>
            <begin position="409"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="530" mass="58178" checksum="41CA90ED26E62107" modified="2019-02-13" version="1">MSKPKDTGSSIIHTQQLQAAMADTFIEHMCLLDIDSEPAVARNTGIICTIGPATRSVEMAKEMIKAGMNIARMNFSHGTHEYHAETIKNVRDATESFVPGSVDYRPVAIALDTKGPEIRTGLIKGSGTAEVELKKGETIKITLDDQYTDNCDEKILWLDYKNITKVVQVGSHIYVDDGLISLKVKEVGSNYLICDIENGGTLGSKKGVNLPGAAVDLPAVSEKDIQDLQFGVEQGVDMVFASFIRKAADVHAVRKVLGEKGKDIKIISKLENHEGVRRFDEILEASDGIMVARGDLGIEIPTEKVFIAQKMMTGKCNRIGKPIVCATQMLESMTKKPRPTRAEASDVANAVLDGNDCIMLSGETAKGDYPLEAVRTQHLIAREAEAAMFHRQVFEELRRLTHLTRDPTESVAIGAVEASFKCCASAIIVLTKTGRSAHMLSRYRPRAPIIALTRCGQAARQAHLYRGIYPVLYTKTANDVWAEDVDLRVNFAMEVGKHRKFFKTGDMAIVVTGWRPGSGYTNTMRVVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8H7</accession>
    <name>A0A3P9B8H7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-BAR domain only protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FCHO family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B8H7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006209"/>
    <dbReference type="Ensembl" id="ENSMZET00005006498.1">
        <property type="protein sequence ID" value="ENSMZEP00005006209.1"/>
        <property type="gene ID" value="ENSMZEG00005004754.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157105"/>
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            <begin position="1"/>
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            <begin position="496"/>
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    <sequence length="1074" mass="117770" checksum="F230C97ADB02429B" modified="2019-02-13" version="1">MKHGQISTKELTDFIRERSTIEEAYARSMTKLAKSAGNFSQLGTFAPMWDVFKGSTEKLASCHMELVRKLQELIKEVQKYVEEQSKAHKKTKEEVASTLEAVQNIQSIFQALQKSKENYNAKIVEQERLRKEGATQRDVDKAGVKAKKATETYKSYVEKYATAKSEFEQKMTETAQKFQDIEENHILHMKEIIQSYSLYVDETHIQIGEVHHEFVRNIENTSVESLIQKLAESKGTGKERPGPIEFEECNVAIAAEGAKPRRRKLLIPGRRKDKDTDSTESTEVEAANTANGAPPGYFADIQNANVPQVDEEGFCIRPEVNENDAKENSFYSSSDSEDEDEPRKFHVQIKPVQPNNGVHQNQANIDELKASIGNIILSPSTSGQMRRNQSRITGVSTVRSKTKGFGDELGKPRVPTSFELTNNDLLSLDPLSPAQAIRSSSAVSSSADLASIFFSNPPSPPFLVNDSDSDVFLPETSAETVPQRERYPPLAESQQSKDVYSFSSSTSSPWDSPENPFQALKPVPARAQSAPITRPTEPVDPIKNSDTPSPPKSADTFSSVSWAQSQWIAFSDNFAPPPPRCQSSGSSVKELQKKQSGSSRSGHFLSDESADAFYKAASSRDDSSFSFTDVFSGITDRAAAPTSKIFNVPVPNRPTTPLAPGALVPPPRPSSRPKLPAGKLTGINEIVRPFSPPKASSPTPTAPLARAESSSSLSSNASLSAGNTPTVVQCTLSSPRPRFPSFTPLLTGAEHTFALPLSSPEPELLSLSPFFPLNQKDDMFIAKLPTFEKRCETPAGTSRGPSPVTLASQDALPIAVAFTESVNAYFKGADPTKCIVKITGDMTLSFPMGIIKVFTTNPSPAVLTFKLKNTSRLEQILPNQQLLYSDPSQSDSDSKDFWFNMQALTSYLRKASEQSPSASYYNVDILKYQVMSDGIHSTPLNLAVYWKCTASTTDLRIDYRYNPESMDSPSPLTNVQILVPVDGGVTNMQSLPNSIWNSEQSKCLWRLTDISEKSENDGAGSLRAKFELSNGPSHPSTLAVQFMNEGSTLSGVDMELQGAGYRLSLSKKRFATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAE7</accession>
    <name>A0A3P9BAE7_9CICH</name>
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        <submittedName>
            <fullName evidence="5">Pleckstrin homology domain containing A6</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005005175.1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="PKHA4-7_TBCA"/>
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        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
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        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 6"/>
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        <property type="entry name" value="TBCA_PH"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_DOMAIN"/>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="229"/>
        </location>
    </feature>
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            <begin position="397"/>
            <end position="422"/>
        </location>
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            <begin position="609"/>
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        <location>
            <begin position="728"/>
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        </location>
    </feature>
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        <location>
            <begin position="864"/>
            <end position="883"/>
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    </feature>
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        <location>
            <begin position="897"/>
            <end position="933"/>
        </location>
    </feature>
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        <location>
            <begin position="480"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
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            <begin position="398"/>
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        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="933" mass="105453" checksum="15C111F3209DF93F" modified="2019-02-13" version="1">MCEEECLCLCHCISQACSDHYGPILWETFNVEAEGIAGCPRRAVLIPVMFGLDIPASFYCFLILPIFTNPSCNCYFSHIFVALLKCNILDIFFTFLIFLFTDDKEDTVLGSLPLLSFQIGGVELSENITCKFAFKVEHVGTRTYYFSTDSYAEQEEWIRALSDAAEVTSQPRNSRSAEREPIHPSIHLHPLCPGPGRGGSSLCKEAQTSLSPATSSSLSGGIPRRSRPAERYNLSRGAQGHPCQMPEPPQLAPFDVSSSCSTLTHFCRFVPRTAPERLAQRKCSMAQLQQWVNQRRGMASQEDINRPPSYYSVNQEVSAGYYNFVDEYSLYLPGVRPDSICSMSAVGGYDRLWTIEQKRHSLRDEPHRLYRKQMPQDQWGPQYYGGMETSMRSLFIQPRSKSVPRSPSSSSRRPYSPASCTYASPARSLSNGFDRFSGRMNEDAIYPPVYSLRRSFSSPKVNRFTVFKLLGRLCEQNQILKDHEAVVHRLRMNKDSLEEALLATHQEMEIYHNQPLIMEKLQFKKETQQNQLINIRGELSQASSALTTACMEFEALEDEANAIHGDLWEQLNAGGQSELVRRHIQKEFWRVQDVLEGLQKNSLSRGIKTAKGRGSFTTNSPASPLSSVSLTSPLSPYSPVPVCQASPTKELGLENTNMFFLACTYKCIYFFTCTVGIVPPRTKSPTDESQRNFTEVHRRNSRVLNGVSRERPKSAAFPTEIKMKMSVEEQNERLRRNQCSSMRDKRRSLNLSGGQSPANYKVVRRRLTAHEIDIKDLEKAVRGQGQESPEEEIARLRCLQIEPEHYNISKEMAPDKVLIPERYLDVENNTLLSPEEQKEKQKKLERIKTLIAKSNLQNMVPLLDGPVEGGAPASSQQQLQEQEKRIEISCALAAEASRRSRLLSGEHSHHMASPCRTTESPRGAPSSTDDKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAF6</accession>
    <name>A0A3P9BAF6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cell adhesion molecule 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024660709.1">
        <property type="nucleotide sequence ID" value="XM_024804941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAF6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006888"/>
    <dbReference type="Ensembl" id="ENSMZET00005007191.1">
        <property type="protein sequence ID" value="ENSMZEP00005006888.1"/>
        <property type="gene ID" value="ENSMZEG00005005287.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470234"/>
    <dbReference type="CTD" id="562183"/>
    <dbReference type="GeneTree" id="ENSGT00940000156093"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008037">
        <property type="term" value="P:cell recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042271">
        <property type="term" value="P:susceptibility to natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05881">
        <property type="entry name" value="IgV_1_Necl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000013">
        <property type="entry name" value="cell adhesion molecule 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000184">
        <property type="entry name" value="cell adhesion molecule 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF2">
        <property type="entry name" value="CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018008333" evidence="11">
        <location>
            <begin position="29"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="134"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="234"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="420" mass="46115" checksum="041BF436D34D2BBE" modified="2019-02-13" version="1">MANTGSGSLAISFFVFVISAAFLPKGAAETLTVEGQNLATDNVTVIEGETATISCRVRNNDDSVIQLLNPNRQTIYFKDVRPLKDSRFQLVNFSDNELRVSLSNVSLSDEGRYVCQLYTDPPQEAYADITVLVPPGSPIIESREDVVSEGNETELTCTAIGGKPAAYIRWMKGEEELTGETTVEETYDRMFTVTSRVRFSVTKEDDGMPVDCIIDHPAVKDLLAQRHLEVLYKPEVKIVVTYPEGLTREGDNLDLTCIAEGKPHPHQINWLRVDEDVPPHAVVTGSDLYIENLNKSYNGTYRCVASNAVGEAYVDYILYVHDAPTTIPTPTTNPVNTQDSRAGEGAPQKIDHAVIGGVVAVVMFAILCALIVLGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGHNNTDEKKEYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCL7</accession>
    <name>A0A3P9BCL7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4200 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCL7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007506"/>
    <dbReference type="Ensembl" id="ENSMZET00005007822.1">
        <property type="protein sequence ID" value="ENSMZEP00005007506.1"/>
        <property type="gene ID" value="ENSMZEG00005005725.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167349"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF3">
        <property type="entry name" value="CILIA AND FLAGELLA ASSOCIATED PROTEIN 100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018075881" description="DUF4200 domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4200" evidence="5">
        <location>
            <begin position="112"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="484" mass="56545" checksum="92EBD0C70B4D4E82" modified="2019-02-13" version="1">MDLCCVKVMLLFALCAQEMRKFLALPIDEKTTHAARVTAKLKNELVGEVEDEAEEEKKGGNEKMTNLKPIKSRTVPPKQTSGGRMKQGKWKRSRKFKIYVNRYDQFNMLFLSVMTKRSEILRMDEAIAKEEKLLKHLERSIERDNVRFEEFLRENEKKSVEARTLYEQEARSTQEKNNEIRRLTAEILTIKSELASFEEILVDYKSYKDLLFKLSPPEWQKAQRPKVMSCKALSFHSWLCLIFLHIHCLCHSFDVVLNVVVKHLGAPSIHPLSETSHPRCKPSQPVQEKRENERPADEPELYFTDPQQLLDLMTELTEQNLSLIQNSTRVEETLEQLQQSLKTTKKNQLERKVLLHVSLNTQDQVTQNTPLHQAALGDFYRPRNHFAYPQDVLLDALSEKVAEVHRSCMDDRMTKLNTLEKLTNIEKRLSLLLQSLESIPEEKLELMKKIKDSERRTRYCVPQWLNVPPSAHLAIEFFTCKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEC5</accession>
    <name>A0A3P9BEC5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Forkhead box protein N3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004542303.1">
        <property type="nucleotide sequence ID" value="XM_004542246.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEC5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008254"/>
    <dbReference type="Ensembl" id="ENSMZET00005008582.1">
        <property type="protein sequence ID" value="ENSMZEP00005008254.1"/>
        <property type="gene ID" value="ENSMZEG00005006293.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463584"/>
    <dbReference type="KEGG" id="mze:101463584"/>
    <dbReference type="CTD" id="555843"/>
    <dbReference type="GeneTree" id="ENSGT00940000167372"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20059">
        <property type="entry name" value="FH_FOXN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000167">
        <property type="entry name" value="forkhead box protein N3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047404">
        <property type="entry name" value="FH_FOXN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047119">
        <property type="entry name" value="FOXN2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13962:SF32">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13962">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="12">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="392"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="486" mass="52421" checksum="AFC9ABF486BEEF06" modified="2019-02-13" version="1">MGPTMPPSKKAQSPSSGASASQGMSPLYRQGDAATAASEAEAADLSLSLSASFSKAEDEELTSLSWLHESTDLLNSFSHSGLRSVSPLQDPDGQHPRSPSSSSPSPDDPLLGDAHSAYDLTAGANRKPPYSFSCLIFMAIEDAPNKRLPVKDIYGWILEHFPYFASAPTGWKNSVRHNLSLNKCFKKVDKDRSQSIGKGSLWSIDPEYRHNLIQALKKTPYHPYSPSLTTPSTSPPTLPQTFHHSPPLWSGSPLFRKNGGVLLQVPRGVIQNGARVRSQALFPVIRPLPVSPVGSRTSAIRSSLGDYLSRGQDSPTCYSPPPCGEDLQDDHTYSTAKSPSRLCSSQVTSPSSPVDDDDIIAVEIQSDVKPEPREIPLDSHVTTAATTTTYISQQPPRGQRRSLGGAGTLAGSSLPWTKSRARGISDTLPLKKRRAATVEKPPESDDEEMKEAAGSLLHLAGVRACLNNITNRTAKGQKEQKEALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGE1</accession>
    <name>A0A3P9BGE1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="14">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="14"/>
    <dbReference type="RefSeq" id="XP_004566903.2">
        <property type="nucleotide sequence ID" value="XM_004566846.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGE1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008816"/>
    <dbReference type="Ensembl" id="ENSMZET00005009156.1">
        <property type="protein sequence ID" value="ENSMZEP00005008816.1"/>
        <property type="gene ID" value="ENSMZEG00005006688.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101475903"/>
    <dbReference type="CTD" id="26330"/>
    <dbReference type="GeneTree" id="ENSGT00940000160272"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF79">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="12">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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            <dbReference type="ARBA" id="ARBA00023152"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="335" mass="35834" checksum="034161120E1AE73A" modified="2019-02-13" version="1">MSDLCVGINGFGRIGRLVLRACLQKGIKVVAINDPFIDLQYMVYMFKYDSTHGRYRGEVSADNGKLVVDGQAISVFQCMKPAEIPWGSSGAIYVVESTGVFLSVEKASSHIQGGAKRVVVSAPSPDAPMFVMGVNEDKYDPSSMTIVSNASCTTNCLAPLAKVIHDSFGIEEALMTTVHAYTATQKTVDGPSAKAWRDGRGAHANIIPASTGAAKAVGKVIPELNGKLTGMAFRVPVADVSVVDLTCRLSKPASYAEIKEAVKKAAEGPLKGVLGYTEDQVVSSDFIGDTHSSIFDAGAGISLNDNFVKLISWYDNEYGYSNRVADLLLYMHSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIX0</accession>
    <name>A0A3P9BIX0_9CICH</name>
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            <fullName evidence="6">Large ribosomal subunit protein eL31</fullName>
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    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573640.2">
        <property type="nucleotide sequence ID" value="XM_004573583.4"/>
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    <dbReference type="Ensembl" id="ENSMZET00005010252.1">
        <property type="protein sequence ID" value="ENSMZEP00005009889.1"/>
        <property type="gene ID" value="ENSMZEG00005007495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476318"/>
    <dbReference type="KEGG" id="mze:101476318"/>
    <dbReference type="CTD" id="6160"/>
    <dbReference type="GeneTree" id="ENSGT00950000183030"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
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        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="124" mass="14321" checksum="6AF30176703B7724" modified="2019-02-13" version="1">MAPTKKGEKKKGRSAINEVVTREYTINVHKRIHGVSFKKRAPRAIKEIRKFAVKEMGTPDVRIDTRLNKAVWSKGVRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTCKGLQTVNVDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQJ3</accession>
    <name>A0A3P9BQJ3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proliferation-associated 2G4, a</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544946.1">
        <property type="nucleotide sequence ID" value="XM_004544889.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQJ3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012198"/>
    <dbReference type="Ensembl" id="ENSMZET00005012626.1">
        <property type="protein sequence ID" value="ENSMZEP00005012198.1"/>
        <property type="gene ID" value="ENSMZEG00005009163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475314"/>
    <dbReference type="KEGG" id="mze:101475314"/>
    <dbReference type="GeneTree" id="ENSGT00940000154281"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000008">
        <property type="entry name" value="Proliferation-associated 2G4, b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="53"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="424" mass="46919" checksum="7ED109B9871E4671" modified="2019-02-13" version="1">MWEGLAVAASVRAEPRGTVAVHSRLATSYYTAKMSDDEQEQTIAEDLVVTKYKMGGDIANQALRLVMEAAKPGVSVLSLCEKGDAYIMVETGKVFKKEKEMKKGIAFPTSVSVNNCVCHFSPLKSDPDYTLKDGDLVKIDLGVHVDGFIANVAHSFIVGASKENPVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKIAQSFKCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQRKDHEKAEFEVHEVYAVDVLISTGEGKARDSGLRTTIYKRDPSKQYGLKMKTSRTFFSEVERRFDAMPFTLRAFEDEAKARLGVVECAKHELLQPFSVLHEKEGEVVAQFKFTVLLMANGPHRITNGPLDPELYKSEHEVQDPELKTLLQSSASRKTQKKKKKKASKTAENASGQPTEDTEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRN6</accession>
    <name>A0A3P9BRN6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRN6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012605"/>
    <dbReference type="Ensembl" id="ENSMZET00005013049.1">
        <property type="protein sequence ID" value="ENSMZEP00005012605.1"/>
        <property type="gene ID" value="ENSMZEG00005009474.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234575"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051379">
        <property type="entry name" value="C-type_Lectin_Receptor_IMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46746:SF9">
        <property type="entry name" value="CD209 ANTIGEN-LIKE PROTEIN C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46746">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="112"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="233" mass="26338" checksum="FCC83D2C74219F14" modified="2019-02-13" version="1">VKVKHKATEQTPDTNNLKRNQTKLTLQMNNLTQVITVLEKNVTNLTAENQNLRGKNEELEAEKKNLTDQIQNMTTSWNELNVSRAQWSIDAYCPKTNNNRMCKICQTGWLPFQSGCYAINNPEASEQQKTWKGAQDDCIGKISDLAVVNNETEKSYISDNSWDSSGNKGYWIGLRVKDGNWKWVDGRNLTKSAWIPGSPTDGQCAISVTNQGFKSVSCSEQNRWICKKKALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRQ4</accession>
    <name>A0A3P9BRQ4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein max</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Myc-associated factor X</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004540811.1">
        <property type="nucleotide sequence ID" value="XM_004540754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRQ4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012604"/>
    <dbReference type="Ensembl" id="ENSMZET00005013048.1">
        <property type="protein sequence ID" value="ENSMZEP00005012604.1"/>
        <property type="gene ID" value="ENSMZEG00005009472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485218"/>
    <dbReference type="GeneTree" id="ENSGT00530000064011"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11406">
        <property type="entry name" value="bHLHzip_Max"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000049">
        <property type="entry name" value="MAX isoform 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="150" mass="17074" checksum="9FD40BCEEA3EA236" modified="2019-02-13" version="1">MSENDDIEVDSDADKRAHHNALERKRRDHIKDSFHSLRDSVPALQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKKQNALLEQQVRALEKAKGNTQLQTNYSSDSSLYTNRKGSAVSAFDGGSDSSSESESDETPNRKKLRLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTV6</accession>
    <name>A0A3P9BTV6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VPS26 endosomal protein sorting factor C</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTV6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013066"/>
    <dbReference type="Ensembl" id="ENSMZET00005013515.1">
        <property type="protein sequence ID" value="ENSMZEP00005013066.1"/>
        <property type="gene ID" value="ENSMZEG00005009816.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183064"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000008">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="248" mass="27854" checksum="25B30BB6C096DFE5" modified="2019-02-13" version="1">MSVTLDIRLKRANKVYLEGPIQLISSNIEVAKAGKIPGGKTEIPFEFPLHTKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLSRSCEFIVHCQPQKSKVIPTPVNFTITPDTLQSREKNSLPKFLIRGHLDATNCVISLPLTGEVVVENSDVPIKSIELQLVRVETCGCAEGYARDATEIQNIQIAEGDVCHSLAIPIYMIFPRLFTCPTLETTNFKVEFEVNVVVVLHDDHLITESFPLKLCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BUY4</accession>
    <name>A0A3P9BUY4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Immunoglobulin heavy variable 6-1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BUY4"/>
    <dbReference type="Ensembl" id="ENSMZET00005014259.1">
        <property type="protein sequence ID" value="ENSMZEP00005013790.1"/>
        <property type="gene ID" value="ENSMZEG00005010388.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286938"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:003074">
        <property type="entry name" value="Immunoglobulin heavy variable 11-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="101" mass="11433" checksum="5430257BFCF49E8F" modified="2019-02-13" version="1">GQTLIESKPVIKRPGESHRLTCTGSGFTFSSYPMNWVRQAPGKGLEWIAFVHTGSSHFFYSQSVQGRFTISRDDSSSKVYLQMNNLKTEDTAVYYCARQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVQ4</accession>
    <name>A0A3P9BVQ4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein serine kinase H1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564660.1">
        <property type="nucleotide sequence ID" value="XM_004564603.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVQ4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013716"/>
    <dbReference type="Ensembl" id="ENSMZET00005014185.1">
        <property type="protein sequence ID" value="ENSMZEP00005013716.1"/>
        <property type="gene ID" value="ENSMZEG00005010332.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483906"/>
    <dbReference type="KEGG" id="mze:101483906"/>
    <dbReference type="CTD" id="5681"/>
    <dbReference type="GeneTree" id="ENSGT00940000157041"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14087">
        <property type="entry name" value="STKc_PSKH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="108"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="434" mass="49134" checksum="6DD8A3C8EB7BB8F2" modified="2019-02-13" version="1">MGCRNSKVLPEPPEDVKLDLVKKVDPQPQTDIYKHFIRGDGSGSKMGVAGGGAGDKAEITSPHQAQSHTATPTASAHLPKDLSELPDPQRRKVAKYRAKFDPRVTAKYEIKALIGRGSFSRVVRVEHKSTRQPYAIKMIETRYREGREVCESELCVLRRVRHTNIIQLMEVFETAERVYMVMELATGGELFDRIIARGSFTERDATRVLQMVLDGVKYLHTLGITHRDLKPENLLYYHPGPDSKIIITDFGLASSRKKGGECLMKTTCGTPEYIAPEILVRKPYTNAVDMWALGVISYILMSGTMPFEDDNRMRLYRQILKGKYSFSGEPWPSVSNLAKDFVERVLTVDPSERLTAGQALKHPWIVSMAASSSMKNLQRCISHNLLKRASSRCHSTKSSQSTRSSRSTKSNKARRVREKELRELNRRYQQQYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVW1</accession>
    <name>A0A3P9BVW1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014052"/>
    <dbReference type="Ensembl" id="ENSMZET00005014524.1">
        <property type="protein sequence ID" value="ENSMZEP00005014052.1"/>
        <property type="gene ID" value="ENSMZEG00005010424.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158164"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF15">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="8" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="18 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="855"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="893"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="967"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="29">
        <location>
            <begin position="1427"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1264"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="1264"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00025760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1672" mass="189633" checksum="EDB8733761267CB8" modified="2019-02-13" version="1">FIPSSWDQHRCCCGHLIGEHSWQDSLPPLSLCPGPGQDVEEEWSMERHTRASPTNAYGTVDFEDTATRVCRAKYVRVAVDSKPEALLQLMLREWQMERPKLLLSVHGGSENFTLPPKVNQAFSKGLITAALSTGAWIFTDGINTGVSKYVGDAVKSFGSHDLRKRNTVGITPWGVIDNNMDLIGRDVFRPYQPLGNPLSKRACLNGFHSHFLLVDDGTLGKHGCQQGLRRKLEKHIQLQKIHPRLNQGVPVVCVVVEGGPSVVSTVLDYVSTVPPVPVFVFEGSGRAADLLVQYVGCYRPVVDNFLTTIGDVFGMERTEATDLYTLLLQCMDHRQSITIFDSESDDQMAPDAAILTATLKGTKASPSEQLSMTLAWDRADIAQKDVLVYGQHWQVGSLEQAMLDALVMDRVSFVKTLIDNGMTMSRFLTVDRLEEHLLFLICYRLSIIDMGLVIEYLIGGAYRSTYTRKQFRAAYSRLHEKVSNDCILFLCPSTRNRSLQDLHFFRTAQPYKRKEQDVSPSTSGDVSSPGLDDAPLLVPFNFNDLFVWAVLQQRQQMALFLWQHGEEALARATVACKLYRSMAFEARQSSLDDNIIERFKTYSLEFGKLAVDVLDCAFRQNEQMAMKLLTYEMEAWSHFTCLQMAVSSCHRPFVSHSCTQTLLTDLWTGPLNMRKNSFLKIILSLLLPPAILLLEFKSKAEMCHVPQTHEGSRDAEQGLSFQDKRVGPVSETMSSITVRCVSWITTLYDFYTAPVVKFWFHTMSYLAFLMLFSYVVLVKMEDQPSVQEWLVIAYILSTAAEKTREILMSEATKLSQKLKIWFSEYWNISDFIAILLFVAGLAMRWHSDPYRTAGRLTYCLDIIFWFIRVMDLLAVNQHAGPYLTMITKMTRNMFYIVVMMAIVLLTYGVSRKAVLSPDEEPSWSLARDIVFQPYWMIYGEVYASEIDPCQEDDSCPPASFLAPFLQAVYMFVQYIIMVNILIAFFNNVYFDMASTSNKLWKYNRYRYIMTYQVRPWLPPPLNLLSHMDLGLRAIYKKFSGDAEREERASGLKLYLGHEDRKKLHEFEERCVQAYFHEKSECPLSSQKNRIKVTAERTEEMCMMVGEVSEKVNFIQDSLSDLDSQLGHLQDLSALAVDTLTLLSASNNLHQEETRLAQCRLITASQHAIPHSWTLPHRSGADGDAANIQRLVAKPYKSTPPSLLKGYTLAGNRRESQECHVGVRGSRGGRYGHTEEPEERAREVLTVVFYAFLFDPEDISEGLTNPAFSCDDSQPTSRSRNSNQWRKPIKSPRWACLSRDRPYGYCRSLSSSMENMTFAGAPLSPTRGSFPSLNESMNNESLLGRRGLKNNTSLRCSRSQGMITHGFENQVNLWTLMFCLYRACVLTAVERNNLMRLAQTIPFTPVSIMGGEEVSVYSLEEVASDADPESSSVSSWSSRGLSAILQPLLSEEGSLDGGLRQGRRVLCTWAEQDVLRPGLVYVVKGFRPEVVRVCKKYFHGSTALQLCLREIQQQRAAQKMMQVFNQVKPDDLHHSPRFLDVSLVLWHSNGQWLTIERNMSGDFMKYNNNTGEEITPCCSLEEMLLAFSHWTYEYSRRELLVLDIQGVGEELTDPTVIMAEDQSVSRGEMLFGPDNLGDAGINGFLQKHSCSAWCHRLGLKGQKHTKPCLLFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BW85</accession>
    <name>A0A3P9BW85_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cystein proteinase inhibitor protein salarin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Inhibits papain and ficin (cysteine proteinases) but not trypsin (a serine proteinase).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BW85"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014122"/>
    <dbReference type="Ensembl" id="ENSMZET00005014597.1">
        <property type="protein sequence ID" value="ENSMZEP00005014122.1"/>
        <property type="gene ID" value="ENSMZEG00005010627.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155176"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2250:FF:000003">
        <property type="entry name" value="Cathepsin L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000006">
        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0789">Thiol protease inhibitor</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="16">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="15">
        <location>
            <begin position="98"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="313" mass="34551" checksum="2F1F1832AC80DFA9" modified="2019-02-13" version="1">MFESTLDAHWELWKKTHGKSYKNDVENAHRRELWENNLKMITVHNLEASMGLHTYELGMNHMGDLTEEEIMQFFASLTPPTDIQRAPSPFAGASGSGIPDTMDWREKGCVTKVKMQGACGSCWAFSAAGALEGQLAKSTGKLVDLSPQNLVDCSGKYGNHGCNGGFMTRAFQYVIDNHGIDSDASYPYTGRDDQCHYNPATRAANCSSYQFLPEGDENALKQGLATIGPISVAIDARRPRFSFYRSGVYNDPSCTQEVNHGVLAVGYGTLNGQDYWLVKNSWGTTFGDQGYIRMARNTGNQCGIALYPCYPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZ96</accession>
    <name>A0A3P9BZ96_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MAL family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZ96"/>
    <dbReference type="Ensembl" id="ENSMZET00005015721.1">
        <property type="protein sequence ID" value="ENSMZEP00005015229.1"/>
        <property type="gene ID" value="ENSMZEG00005011429.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182933"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047123">
        <property type="entry name" value="MYADM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER MYADM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17068:SF2">
        <property type="entry name" value="MYELOID-ASSOCIATED DIFFERENTIATION MARKER-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017980539" description="MARVEL domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="10">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="10">
        <location>
            <begin position="130"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="274" mass="30911" checksum="57B21052FC1711A8" modified="2019-02-13" version="1">PVGIMRIMAAILTCMCFSLAGAAGANSSSYWAWCMFTWCFCFFFTFLIVILEFTTVNSKVPFAWDDFTTAFAMLASLMCLIVSIIYPTFFTCKTCHRAIGASMVSWVCFATYAGEVVLTRLYPRGETSGFLSTLPGIMKMLETFIACLIFVSLDQGQYTGNSGLQWCVAVYSLCFIFSIIIILLTLAQLTSYLPISFDMVVIVYNILAAVMYTTAMVIWPLYSFSKNKQRPPNCGHFCPWDKLVVVTFMTIFNFIVYTLDAVYSIRLVFCIMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZG9</accession>
    <name>A0A3P9BZG9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZG9"/>
    <dbReference type="Ensembl" id="ENSMZET00005015866.1">
        <property type="protein sequence ID" value="ENSMZEP00005015368.1"/>
        <property type="gene ID" value="ENSMZEG00005011534.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166007"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050413">
        <property type="entry name" value="TCR_beta_variable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268:SF102">
        <property type="entry name" value="IMMUNOGLOBULIN V-SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268">
        <property type="entry name" value="T-CELL RECEPTOR BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="151" mass="16818" checksum="3FAA8E471226F38D" modified="2019-02-13" version="1">MIPVFKHCFSTGVSSTYNVLQTPPSIIKKVGQSVSNEIHCSHDVSIFEWILWYKQDKHRAPQFLGYLNLNFPYPEEDVKGKIIFNGNGKEYSNLTISNVSVTDSAVYFCAASQHSTTDPTEATKGVSLKLSQPQEATLVIRGVGCSNFFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZN3</accession>
    <name>A0A3P9BZN3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Scm like with four mbt domains 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004545379.1">
        <property type="nucleotide sequence ID" value="XM_004545322.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZN3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015096"/>
    <dbReference type="Ensembl" id="ENSMZET00005015586.1">
        <property type="protein sequence ID" value="ENSMZEP00005015096.1"/>
        <property type="gene ID" value="ENSMZEG00005011290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486375"/>
    <dbReference type="CTD" id="51460"/>
    <dbReference type="GeneTree" id="ENSGT00940000157363"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
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        <property type="term" value="F:histone binding"/>
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        <property type="term" value="F:transcription corepressor activity"/>
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    <dbReference type="CDD" id="cd09581">
        <property type="entry name" value="SAM_Scm-like-4MBT1_2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="SLED domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
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        <property type="entry name" value="Scm-like-4MBT1/2_SAM"/>
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    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02820">
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    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
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    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="128"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="244"/>
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        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="5">
        <location>
            <begin position="362"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="798"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="655"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="694"/>
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    </feature>
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            <begin position="695"/>
            <end position="706"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="710"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SMART" id="SM00454"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015096.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="871" mass="98085" checksum="14DA7365C6740F23" modified="2019-02-13" version="1">MSQETLVSDGDSAQDAPDFNWDDYLEETEAVAVPHHSFKHVDQGLQTGLTPGMKLEVCVRSEADSPYWVANIITTCGQLLLLRYEGYQDDRRADFWCDIMTADLHPLGWSRQHDKTMRPPEGVREKHQDWEALLEKALAEECSAPASLLELPQRGRDPVELLCAGCYVELQDSVDPGLAWAAEVEENVGGRLKLRLIGTEGLPDTPATLWLFYLHPRLHPPGWAKEHGCTLRPPSDLLGLRTEEEWEDVRQRISDLPQDEALTAELTKDQPAISAHCFKEGMKLEAVDPAAPISIRPATVTRVYNEQYFLVTMDNLCDIEESESAGRSFLCHRDSPGIFPAQWSLKNGLPLSPPPGYQGPDFDWADYLKQCEAEAAPQHCFPTEQCEHSFKEAMKLEAVNPLSPENIHVATVTRVKGQYIWLSLEGLKQPMPELIVHVDSLDIFPVSWCETNGYPLVYPIKPSVEKEKKIAVVQPEKHRTPPKSSSPDTVKQQITNQSETGQGNGKYCCPKIYFNHRCFSGPYLNKGRIAELPQFIGPGNCVLVLKEVLTLLINSAYKPSRVLRELQLDQESRWQGHGETLKAKYKGKSYRATVEIVRTADRVADFCRKTCIKLECCPNLFGPRMVLEHCSENCSVLTKTKYSRWQTAYYYGKKKSKRVGRPPGGQTNLDAGVKRRGRRRKRRKQLFVHKKRRSSASVDNTPAGSPQGSGEEEDLDEDDSLSEDSGSEMQDDLQDDSEQSIGKSQPTTPSPSPPATPRPTRRRRKPRSPSFSDDENRPPSPKTPKAEPPQKLCLDTSPLEWSVTDVVRFIRTTDCAPLARIFLDQEIDGQALLLLNLPTVQECMDLKLGPAIKLCHHIERVKLAFYQQFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZP1</accession>
    <name>A0A3P9BZP1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZP1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015379"/>
    <dbReference type="Ensembl" id="ENSMZET00005015877.1">
        <property type="protein sequence ID" value="ENSMZEP00005015379.1"/>
        <property type="gene ID" value="ENSMZEG00005011556.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177378"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050413">
        <property type="entry name" value="TCR_beta_variable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268:SF102">
        <property type="entry name" value="IMMUNOGLOBULIN V-SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23268">
        <property type="entry name" value="T-CELL RECEPTOR BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="136" mass="15832" checksum="FAAB054CD203F2B1" modified="2019-02-13" version="1">LNRQKENKKPIIMCIITGRTYGSYINQASMLWKNQGEDATLNCSHVMTIEFYQMYWYRQLPGEPMKQMVYTIPNAEPDFEPDFRDEKFSVTKPDARSGTLTVKNLVPGDQGLYFCAVSIHSDTLFCSRKFWITKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0Z3</accession>
    <name>A0A3P9C0Z3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0Z3"/>
    <dbReference type="Ensembl" id="ENSMZET00005016345.1">
        <property type="protein sequence ID" value="ENSMZEP00005015834.1"/>
        <property type="gene ID" value="ENSMZEG00005011892.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240400"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF32">
        <property type="entry name" value="BLOODTHIRSTY-RELATED GENE FAMILY, MEMBER 16 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="9">
        <location>
            <begin position="185"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="394" mass="44710" checksum="508E774850C00854" modified="2019-02-13" version="1">MSAASCLLSEDQFLCSICLDVFTDPVSTPCGHNFCKNCISKNWDISYRCQCPMCKKVFRMRPELHINTFISEMVSQFRHEAQQKVSSCSSEQQAAKPGEVPCDICTGTKLKALKSCLVCLVSYCQTHLEPHLTASRLKRHQLIDPEENLESRMCMKHDKPLELFCKTDQTCVCMLCCVFDHKTHEFVPLREEYEGKKAELGKTEAEIQQMIQKTWLKIQGIKESVKMKVSIHPPSYEGTRFSKFVCVLGKQSFSSGRFYFEVQIKYMTKWILGVVRESVNRKEAITPSPDEGYWTVAEHKNICVALDKPQVCLSLQSVPEKVGVFVDYEEGLVSFHNVDHATLIYSFTGCSFMEKLCPLFYPGVNDDGKNSGRLIICPVMVGDGISDDDEDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4U7</accession>
    <name>A0A3P9C4U7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4U7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016916"/>
    <dbReference type="Ensembl" id="ENSMZET00005017456.1">
        <property type="protein sequence ID" value="ENSMZEP00005016916.1"/>
        <property type="gene ID" value="ENSMZEG00005012709.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286939"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000585">
        <property type="entry name" value="zinc finger protein 784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="162" mass="18230" checksum="288B38C3E4C8F56D" modified="2019-02-13" version="1">MEAGSVCSTTAFHSLPLFVSLSLQDQHGKQSNTDGSSSRPCRHCGGGKDFCCDLCGKTFSHQWNLTIHQRRHTGDKMSFCKECGRGFPTPSELKRHEFIHGGVKKNICDQCGSSFFTADDLKRHKRVHTGEKPYKCRHCEKCFTQSSSRNLHEGTHGRELQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C620</accession>
    <name>A0A3P9C620_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM13C</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
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                <consortium name="Ensembl"/>
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        <text evidence="1">Belongs to the FAM13 family.</text>
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                <person name="Streelman J.T."/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004543901.3">
        <property type="nucleotide sequence ID" value="XM_004543844.5"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9C9X7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019090"/>
    <dbReference type="Ensembl" id="ENSMZET00005019703.1">
        <property type="protein sequence ID" value="ENSMZEP00005019090.1"/>
        <property type="gene ID" value="ENSMZEG00005014317.1"/>
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    <dbReference type="KEGG" id="mze:101466205"/>
    <dbReference type="GeneTree" id="ENSGT00940000163989"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC6-RELATED"/>
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        <property type="entry name" value="WD40_RLD"/>
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        <property type="entry name" value="RCCNDNSATION"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="RCC1_3"/>
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    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
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    <feature type="repeat" description="RCC1" evidence="5">
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            <begin position="48"/>
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            <begin position="7"/>
            <end position="18"/>
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        <location>
            <position position="974"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
    <sequence length="1014" mass="112638" checksum="1A2AC113E3C0FA70" modified="2019-02-13" version="1">MQLFCWGDSSSGQFGSQGAPSPVPWTVPGVVTKICCGDRHTLFLNADGDMLSCGHNSQGQLGRQKKKNGKIIAQVEGLGRVVAMACGQDHSLAVSASGHVFSWGAGEDGQLGLPTPSNSHRPSKVPIPLPIPIIQVACGNSHSLALTKGGDVFSWGLNSHGQLGLGKEVPVQDTPVIICALAGVAVTQIAAGGTHSLFLTLADLVYCCGANKCGQLGVNRVDEKGRFNICMVPALRPLSVSFISCGESHSAVLTKDGKVYTFGDGSQGQLGHSTSANEVKPKLVAGVDGPASQIACGRHHTLVLGSSGQLWAFGSGAKGQTGNGHNGGSLTPTLVQFPWTTDDAAAMPSDLKIAAGWNTNFAYSSPAENSVHKQITGRLDETKLQEWLMMEHSNVEAKREIGSMFLTSSSLVASFTKANGFPLEAGDLTVDLEAASRAFDQLFTRQWIKQSVNLVPLCDLLYLSRTALKSPEIILILLTCPLLQEDSNVMNTVLSVAITIAEMSDKTLETLKKWWSSLSPSILMKHIMVFKKALAFMLKNGLLQTHNPGVKFILEALKLLYKANKAGKSYKVPLSTFYVEEITNAVQLDTDIMFWWQFSKEEDDVNTPAIFCRYPFLLTLLHKVAVFNFCAATVKNAHQLAHQAALVPHQPHAPDSPPAPVFQLTLRRSHLVEDTFRQLSAADHCAFQRELLVLFVEDRKTTNVNKRDFFLHVFDELMAPESKRFIYNESQTVAWFPPKPKVEEKTYFLFGVLCGLALYNHNIIHLRFPQALFKKLLRVKPTLDDMKEFDPVLAESWRIILEDYTPDVVQTLDTTFTVSWAGETVELDPNEPGKLVTGSNRKEYVAAFVNYVFNKSVERLFDEFKRGFFKVCNMDVVDFFQPEELQAVMVGQENYDWEVFKKNTFYEGEYHDEHPNIVVFWEVFESLTAEEKKKFLLFLTGSDRVPFLGMESIKMRVAVLPDASERHLPESLTCHFLLLLPIYRRYPVERKMRTRLLQAINHNRGFRKKQRTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCN0</accession>
    <name>A0A3P9CCN0_9CICH</name>
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        <submittedName>
            <fullName evidence="12">Zgc:194202</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <dbReference type="AlphaFoldDB" id="A0A3P9CCN0"/>
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        <property type="protein sequence ID" value="ENSMZEP00005019636.1"/>
        <property type="gene ID" value="ENSMZEG00005014739.1"/>
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        <property type="component" value="LG15"/>
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        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:leukotriene receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leukotriene B4 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF946">
        <property type="entry name" value="LEUKOTRIENE B4 RECEPTOR 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="46"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="324" mass="35998" checksum="E935BA6D6DABAAB4" modified="2019-02-13" version="1">MAQLTNAVVTSNISSSPGYSPHFSWDYSGIAAAVVLSICFLLGFPGNIAVIILKPNWENMSSLTQSLMLNLAVSGLLCMFTVPFWIYSFLNSWTLGLVGCKIITYFGYCSIYASLLTVTVMSVQRYFQVVYLQRNLNHIQAWKLLVPLWLVAMILSIPALVVRQLVEQSDWTYCKHQYYSVNQSMAVLLAEILVGFVSVSVNVFSYICLYREVNQAAFFNNPQTTRLITSIIVTFFVVWVPCLAINVLGVAAISLNNKDLLKFCEAAWGTVTALTFANGAVNPLLYAFTSNGLSTLCQKNAEHLMQKLRITPQSKSANTVSDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CIX3</accession>
    <name>A0A3P9CIX3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sirtuin 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005016462.1"/>
    </dbReference>
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        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL"/>
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    </dbReference>
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        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018131772" evidence="4">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="69"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="210"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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        <location>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="351" mass="38901" checksum="063EC03E22183D7F" modified="2019-02-13" version="1">MASSVSCSLLLLPARLCRSLRSRASWTLSAKGFDQRSSFPSEGATVLSRHARSLCWTQTRGFFSHGGSSSAKQQTLEDIAKSIREQQFKRVVVMAGAGISTPSGIPDFRSPGSGLYDNLQQYDLPYAEAIFEISFFHHNPNPFFALAKELYPGNYRPNLTHYFVYLLHKKGQLLRMYTQNIDGLERLAGIPPEMLVEAHGTFATATCTACLRKYEGEDLRPDVMSGTVPKCPTCKGVVKPDIVFFGEELPRHFFKYITDFPLADLLIIMGTSLEVEPFASLARAVRSSVPRLLINRDLVGPFTWSRRPNDVAQLGDVVSGVQALVDALGWTRELDALMAASTEKSAPKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJ90</accession>
    <name>A0A3P9CJ90_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal-induced proliferation-associated 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005022217"/>
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        <property type="gene ID" value="ENSMZEG00005016660.1"/>
    </dbReference>
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        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06745">
        <property type="entry name" value="PDZ_SIPA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000002">
        <property type="entry name" value="Signal-induced proliferation-associated 1-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050989">
        <property type="entry name" value="Rap1_Ran_GAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711">
        <property type="entry name" value="RAP GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15711:SF64">
        <property type="entry name" value="SIGNAL-INDUCED PROLIFERATION-ASSOCIATED PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21022">
        <property type="entry name" value="Rap-GAP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="5">
        <location>
            <begin position="467"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="927"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1003"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115328" checksum="4EC96E30A2DECD4B" modified="2019-02-13" version="1">MQSDDLFIRKFRRQNQRPPIAAVNFDPKRETGVVEWPPRRDGDGAEADSLTPSRAGLTLRSMGRGHIMQRSNSDVTLGDLDSSGKAGGKTARAVGEKVDAGVQGDTGVLLHREYGSLSSLERQTQAQEPRADDQGPLSPSALRFKDPFLLLGLQGHPPEPDGYFRGVCTVDGPKPVKPPKPEGLSKKSKPTTSQVPQPVPYDNIGGGAWVRSFAHYDVQSILFDLTEVATNRDSIGRKKNITSGASAASQPRPLSLSTPSSPAQGGGGSTGNAEDNEQSMMLDEGDGNDNELLLSCPHFRNETGGEEQAGLGRSQGRKGLWSSLRIPNDAVSVLEEPRESNVQQQGKSNYFIEHADLGAHYYRKYFYMKEHQNFFGIDERLGPVAISFRREEKEGSSGAQNNCRIIFRTTEMKTLRGSILEESVPSAARHTTPRGLTPKRLLEFIMPELNQHCLRLASNSPKVRDTLLKLDEQGLNFQRKVGIMYCRAGQSSEEDMYNNESSGPAFEKFLDLLGERVRLKGWEKYRAQLDNKDSTGTHSLYTRYQDYEIMFHVSTMLPYTANNTQQLLRKRHIGNDIVTIVFQEPGAMPFTPKSIRSHFQHVFIIVQVHEPCTENTYYVAVTRSKDIPLFGPLFPKGARFPRSAAFRDFLLAKAVNAENAAEKSEKFRSMATRTRQEYLKDLAENYVTTTPIDSSTKFPLLSLGGKRKDKMKGAKGAELHSNGALVWAVMVNSIDEWEAGEHKLPCLLAVSTESVVLIERYSRKVVFNCSCRDVIGWKAVTEPKDGGPCLDIFYERGESVSISMMENQAEDIREVVQRLELVTRGCEALEVTPLRDGVGQPGFLMNEEGFVTELQRFCYAESGGLQLWARVVRLCGHSLVHLSLDERTRLLRTAHKIHITVIPPDENGKPRFSELYLKAIKDAECKPGENQSGEAWVLDEREEEEEAKKEDDDVKTGGVEEPDTKEAQAETDEGEEQLCDKVESERNPYSLLTMPSLPLLRATSLQDQPANQGQEGSASQLPRSYSLEKQLSYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKU6</accession>
    <name>A0A3P9CKU6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Copine-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Copine III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CPNE3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Interacts with ERBB2 (preferentially with the tyrosine phosphorylated form); this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner. Interacts with SHC1; this interaction may mediate the binding of CPNE3 with ERBB2. Interacts with RACK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copine family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKU6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022717"/>
    <dbReference type="Ensembl" id="ENSMZET00005023467.1">
        <property type="protein sequence ID" value="ENSMZEP00005022717.1"/>
        <property type="gene ID" value="ENSMZEG00005017000.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154968"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038128">
        <property type="term" value="P:ERBB2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000042">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000099">
        <property type="entry name" value="Copine 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF22">
        <property type="entry name" value="COPINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="131"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="541" mass="60371" checksum="592AECEC99AF82BF" modified="2019-02-13" version="1">MAAVGVQQTRVADCVTKVLLSISCDHLLDMDAFSKSDPLCVLFMNSSGNHWFEVGRTEKIENCLSPKFSKPIVLDYYFEMVQKLRFEVHDIDTENCSLQEADFLGQLECTLGQIVSSRKLTKPLVKKDKMPAGKGTITICAEEMTDNRVVAFEVAARKLDKKDFFGKSDPFLEFYKQTETGWQLAHRTEVVKNNLNPVWRPFQIPIQSLCAGDVEKPIKIDCYDHNNSGDHDFIGTFQTSLSQIQQATETFAAEFDCINSKKKEKKKGYKNSGIIVIKKSKIVRQYTFLDYIMGGCQINFTIAIDFTGSNGDPKFPQSLHYINPQGYNEYLAAIWAVGNVIQDYDSDKMFPAFGFGAQIPPAWQVNHEFPINFNPSNPFCAGVEGVVAAYQQCLPQVKLYGPTNFSPIINHVAQFGRQALQQQTASQYFVLLIITDGVITDMDETRNAIVNASRLPMSIIIVGVGGADFSAMEFLDGDDGVLRSTTGENAMRDIVQFVPFRKFQNAGSAALAQSVLAELPDQLASFFKLFELKPPTEPSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CL16</accession>
    <name>A0A3P9CL16_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Solute carrier family 41 member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) &gt; Ni(2+) &gt; Co(2+) &gt; Fe(2+) &gt; Mn(2+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Co(2+)(in) = Co(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28578"/>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Fe(2+)(in) = Fe(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28486"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Mn(2+)(in) = Mn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28699"/>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ni(2+)(in) = Ni(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29831"/>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570861.1">
        <property type="nucleotide sequence ID" value="XM_004570804.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CL16"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023023"/>
    <dbReference type="Ensembl" id="ENSMZET00005023780.1">
        <property type="protein sequence ID" value="ENSMZEP00005023023.1"/>
        <property type="gene ID" value="ENSMZEG00005017242.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469257"/>
    <dbReference type="KEGG" id="mze:101469257"/>
    <dbReference type="CTD" id="564932"/>
    <dbReference type="GeneTree" id="ENSGT00950000183042"/>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000002">
        <property type="entry name" value="Solute carrier family 41, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF25">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 41 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="19">
        <location>
            <begin position="132"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="19">
        <location>
            <begin position="347"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU369007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="502" mass="54404" checksum="C4F2F68C0A938166" modified="2019-02-13" version="1">MVVQESQDTKLTHSDSVSPSQQNRSNTSLSQFSGNSQHFTSNENIYYEPEEYTETDFLLPNQLYGRSRLTRSPQPKDANVSGALEESICSMVVQILVPFLLAGLGTVSAGILLDIAQSWEVFQEITEILILVPAVLGMKGNLEMTLASRLSTAVNAGKMDSPREKWMLIAGNLALKQLQATVLGLLASLMASLLGWMAEGQMPFNHIMLLCSTSVSTAFVASLLQGIVMVGVIIGSKRIGINPDNVATPIAASFGDLITLALLACFSQWFYSFIELYPYVLYLVNLSFLCLIPAWVAASSKHPASEILLHTGWEPIIIAMLISSIGGVILDKTVLDPNLAGIIVYAPVINGVGGNLVSIQSSRISTHLHLKYSPGQLPEGRQSCSNPWHTFFGSGANHRSAKILLLLVIPGQLIFLHVIHLIKGGHTLPSPLFTIAFLFASLIQVLILLCMADCLVHCLWRRGKDPDSYSIPYLTALGDLLGTALLSIAFLMLWCIGDPGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CME8</accession>
    <name>A0A3P9CME8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anillin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Bleb</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CME8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023505"/>
    <dbReference type="Ensembl" id="ENSMZET00005024277.1">
        <property type="protein sequence ID" value="ENSMZEP00005023505.1"/>
        <property type="gene ID" value="ENSMZEG00005017587.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008749"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032059">
        <property type="term" value="C:bleb"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01263">
        <property type="entry name" value="PH_anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000111">
        <property type="entry name" value="anillin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037840">
        <property type="entry name" value="PH_Anillin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF27">
        <property type="entry name" value="ANILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="132" mass="14781" checksum="C05C5ADF473A290A" modified="2019-02-13" version="1">VASPGGPNAVRTSNFALIGAYKLTLASIGKTQFPLEKVPFLCPLEGHIYLKMHCEVGSKVEERGFLTMFEDVSGFGAWHRRWCVLSGYCISYWTYPDDEKRKNPIGRINLSNCTSKAVEPASREFCARPNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CP94</accession>
    <name>A0A3P9CP94_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma-glutamylaminecyclotransferase</fullName>
            <ecNumber evidence="6">4.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May contribute to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:16961"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:133752"/>
            <dbReference type="EC" id="4.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.8" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CP94"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023849"/>
    <dbReference type="Ensembl" id="ENSMZET00005024633.1">
        <property type="protein sequence ID" value="ENSMZEP00005023849.1"/>
        <property type="gene ID" value="ENSMZEG00005017844.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010543"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042219">
        <property type="term" value="P:modified amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.10:FF:000008">
        <property type="entry name" value="Gamma-glutamylaminecyclotransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639126-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="172" mass="19875" checksum="2B60A5DE30EFEBC4" modified="2019-02-13" version="1">SVCKYLVTNVRLWSSVLMTRIFVYGTLKKGQPNNYRMFDNNNGKAEYLGSAFTSQKYPLVITTKDNIPFLLNIPGQGHRVHGEIYKVDDQMLKFLDDFESVPTLYQQTVVQLEVKEWVGKMEGEEKVSPGSIMDVFVYTATTYEPDWRSLPCYENYDSEGDHGLKYNTEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQD2</accession>
    <name>A0A3P9CQD2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein phosphatase Slingshot homolog 1</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">SSH-like protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQD2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024563"/>
    <dbReference type="Ensembl" id="ENSMZET00005025366.1">
        <property type="protein sequence ID" value="ENSMZEP00005024563.1"/>
        <property type="gene ID" value="ENSMZEG00005018362.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156133"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11652">
        <property type="entry name" value="SSH-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000423">
        <property type="entry name" value="Slingshot protein phosphatase 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF7">
        <property type="entry name" value="PROTEIN-SERINE_THREONINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="20">
        <location>
            <begin position="238"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="297"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="359"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="664" mass="74916" checksum="B2901C4AC428DC1F" modified="2019-02-13" version="1">VTTPPPPPPPHPRAPSLPGMNDGIVAGLSESFFMVKGAALFLQQGGSTQGPKTPTHHKHAGDLPQHLQVMFKILRSEDRIKLAVRLESSWTDRVRYMVVIYTTGHQDTEENVVLGMDFTDKDSKNCSIGMVLPLWSDTNIHLDGDGGFSVSTAGRSHVFKPVSVQAMWSALQVLHKACEVSRRFNYFPGGIALTWMAFYESCITSEQSCINEWNAMTDLESTRSDSPTMFVDQPTERERTECAIKAKLRNIMMFQDLENITSKEIRNELEQHMNCNLKEYKEFIDNEMLLILGQMDKATLIFDHVYLGSEWNASNLEELRECGVGFILNVTREIDNFFPGLFSYHNVRVYDEDATDLLAHWNDTYNFIVKAKKNNSKCLVHCKMGVSRSASTVIAYAMKEYGWSLEKAYNFVKQKRSIAQPNAGFMRQLAEYEGILDASKQRHNKLWRPGADEEGSDDLQASGHCAGGGETLREEEAWGGCGASPCRGMGLEMEPLDSLNYNYYFRRLSDSALDSEPSTPVRGPPLLGMERVFIEIEDVERDALLEDEGFPMAHLALPGEGTAAQTCGRLDPLEDMRLRLEFSTLEEEDEEERSEESRLGLANLNTNNSNRLAAKRSCPAAFDVSLKKTKHFYSWHMDLIKVDKIPASLHHSTMFGWFCPFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQZ3</accession>
    <name>A0A3P9CQZ3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Placenta-specific gene 8 protein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024661455.1">
        <property type="nucleotide sequence ID" value="XM_024805687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQZ3"/>
    <dbReference type="Ensembl" id="ENSMZET00005025291.1">
        <property type="protein sequence ID" value="ENSMZEP00005024489.1"/>
        <property type="gene ID" value="ENSMZEG00005018311.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:112436263"/>
    <dbReference type="GeneTree" id="ENSGT00940000163701"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="163" mass="17920" checksum="02F122121EA00DCA" modified="2019-02-13" version="1">MAEKPLTDWDSGLCDCFEDARTCCYGFWCCPCLACTVSGRFGENNCLPLCDICGSGVLAAFGIPVCVPPAVLSVRAAMRNRYGIKGSLCKDIAISCFCEWCSWCQMHRELRHRKKTPTVINIQNNTVVNMQPIPTFQPGVMMLPAQPVATGFMSQPTVVVQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRK5</accession>
    <name>A0A3P9CRK5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calmodulin regulated spectrin associated protein family member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The CKK domain binds microtubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CAMSAP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552160.1">
        <property type="nucleotide sequence ID" value="XM_004552103.3"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005024975"/>
    <dbReference type="Ensembl" id="ENSMZET00005025786.1">
        <property type="protein sequence ID" value="ENSMZEP00005024975.1"/>
        <property type="gene ID" value="ENSMZEG00005018643.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482812"/>
    <dbReference type="KEGG" id="mze:101482812"/>
    <dbReference type="CTD" id="57662"/>
    <dbReference type="GeneTree" id="ENSGT00950000182975"/>
    <dbReference type="OrthoDB" id="2125658at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036449">
        <property type="term" value="C:microtubule minus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030507">
        <property type="term" value="F:spectrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.360:FF:000001">
        <property type="entry name" value="Calmodulin-regulated spectrin-associated protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.360">
        <property type="entry name" value="CKK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031372">
        <property type="entry name" value="CAMSAP_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058042">
        <property type="entry name" value="CAMSAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022613">
        <property type="entry name" value="CH_CAMSAP_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038209">
        <property type="entry name" value="CKK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF2">
        <property type="entry name" value="CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17095">
        <property type="entry name" value="CAMSAP_CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11971">
        <property type="entry name" value="CAMSAP_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08683">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25532">
        <property type="entry name" value="CH_CAMSAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="217"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="CKK" evidence="9">
        <location>
            <begin position="1308"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="819"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1061"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="660"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="947"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1173"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1264"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1446" mass="159292" checksum="099E4CA28F75F817" modified="2019-02-13" version="1">MVDSPTMRKTFVVPDIKSLDLYDCTKSKICASVGWLLAKSYGSTENVPAELRDPFYCDQYEQEHLKPPVTHLLQSSELYCRTYNILLGSTATEAQPKDNATLLQLLTQRGVVAKDQDTTVTDADLRHKPIKMSAHLAVMDALMAVGAMETVTAVKTCSSAELLGKAASWEDALLHWVNELNQNLRERTEGAQNDLSETITDPQPVQPSCPTRWYWKLVPLRYRKDKIQSKLKPVFPVVNEVKDLSSGCAVAAVIHYYCPGLLRLEDVCMKDSMSVADSLYNLQFIREFCDSCLKSCCHLALEDMLYTPQELQMNLLSFLAELLSWFEVQRPEFVQPIDMLSESTPVTPSSLSDNSTSPSIFKKPFLPISSSASGSLTQSTSMSHIEGAGKTWSKKPLSRPLSAVSFSIPFGLDSDVDIVMGNPVITRSVSSDQLNPAGQNMARVPYTPPEDLSHLLSKPSGPNGPQRASWATQTPTVPKLAEENDLGTSETGELPTIEEALQIIHNESKMEPRLHPDGAPDGFYLHSPDDPASSRYNGNLPPISSSAPTRSGMMYRPTGESSESTRTRNTSECSRDDDSVLRDGSVDSDASEDMPKAQSTPSTPGAAGGAAIRAGKEVPDSGVKMTSFVERKKKQITDSPKSSDSPQMTSWAQKSEESPSKSPQLNNEMSELGVRLEEKRKAIEAQKKRIEAIFAKHRQRLGKSAFLQLKKEHREGKGEDGQVSTSFTEEDLSRLTLEERLARIELEDQQEQDEEHPTVEDEGNVKRGLALNKQVKEKAGTPGEKHHATPTDKVVAPLGDYNNAVSKLTAALSSLQSDMQRLTEQQNQLMKKKPSPSNNKSWVIPTSPKTSTSAPPPARLSRETTRDLNSASSSPSPSRKITNHTTSPKSPHVHRRAQSVPPKSPKHSRPSDTKVPSLSRVLTPPTNVDRIPHLRRVNPWQSQVQTSSSFSIGDSGSLDELRSLGPTPVPTTTLTPIPASTPTPGPGADDGLSEVGSNDGQSIFSMDLEVGSNHGPLTRKEGVAGGGYSSGAPSECSFESDAPAGMLNGKRSSLIEISLSALGGDDEEDDQVPDALSDSMSDLTEAENKAAVGFFFKDDKDRPEDEMAQRKAAFLEKQQKRTEEMKRRKLEQEKEKESNKPQWMIIEGWGSKNEDRPQTPGTPPKTPPAEGTPQRRGDFTKQEYERRQQLKIMEDLDKVLKQKPTTVRGVKKQRPKTMFRDDSVLSQSPVKGFMGTKLNKVYSHSSMNLSSMANDPGGMTVRKSPSRSHSPARSRGRSPGRIGVQNGEKDWETGSAISSPASIPEYTGPKLYKEPSFKSNKFIIHNAITRCCLAGKVNEPQKNKIVEEMEKSTANHFLILFRDSSCQFRAVYTMNPETDEMARLTGIGPRVITLDMVESIYKYSSDRKQFTVIPSKTMSMSVDAFTIPGHFWQKRPGTPKKFGTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRT2</accession>
    <name>A0A3P9CRT2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005025043"/>
    <dbReference type="Ensembl" id="ENSMZET00005025860.1">
        <property type="protein sequence ID" value="ENSMZEP00005025043.1"/>
        <property type="gene ID" value="ENSMZEG00005018678.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158735"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039797">
        <property type="entry name" value="Pecanex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007735">
        <property type="entry name" value="Pecanex_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF4">
        <property type="entry name" value="PECANEX-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1011"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1121"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1196"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1270"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1298"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="Pecanex C-terminal" evidence="8">
        <location>
            <begin position="1789"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="695"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="786"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="894"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2056"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2152"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2206"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="580"/>
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        <location>
            <begin position="599"/>
            <end position="610"/>
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    </feature>
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        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
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        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
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        <location>
            <begin position="2062"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2260"/>
            <end position="2275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2275" mass="249704" checksum="686A9B3A3FA0B1F4" modified="2019-02-13" version="1">MGSQALQILRQGVWASLTGGWYVDPHQSTFSNCFHLYLWIFLLAFPFLLYMALPPSLLVAGVYSAVVAVFFTAIKVVNYRLHAMFDLGEIVEKKQASLTAEVPRTEEGEEGSGAHEGNQHRDSHVGVEMTVFRKVNSTPPVRCSSQHSLFGLNQVSEFLPQLEDSGGTKDIKELMREQGSNNVIVTSAQREILRQSSQDPIRALNGVSSCIVAALGGEFQGLVGVSGVSAGFEEPGALSIPPSPSSQEDGGEKEHLQEVEMLTEQLSHQSSKDNDLGAYSPLGPSAESESLGDTPLSPLIKSSLSEELSENLLGLGLDPVAFAPGTELPGSRSGVALAAGSTDSCFSAGGATTDRETLSTVSSYRSEKTDSTQLESPSFSQSRPVDGQVSASAPAIGSDIHKPTEDSAVQDGSDTDNLSDSVLLRSPSKEFSLSQGLDRTLVEGEDLPSVPSDIAQPPPLQNSSPSSSGHSEVCELDRNVPVPPLPPPRQTNSVPSGLALGLVCSEPALPISSTPFLLSEQPALQSQQVVRPKDLKLLRASGGSMGHRPGRRKAPRRRAGAGSSSFDCGSYRRHHNHRQHRDYIPVRNRLGTKAYSESLFEDSSDEDDGSDMSAGSSLGSQRRYSSDDDDDDDDDSSSSTSCYSPDLANTGITSTLPPAAQLPTPREGDLPETAGPSHPRAAQRSSSTASAKTHARVLSMDGAGGSQSNAVALPSTLLAMPSTSTPAPRTLTISKSDLEARTIHSDGFAGAHHHRLDSLGGSWTGNQMGWRTGELVEEGAVGGAMATEEGGKHESVSSVKRTQAIRRRHNAGSNPTPPPSTMGSPPSLQDLQRARTSSHSRTRTLPSALQFASSLLLPRSGIHEASTFDDTSEGAVHYFYDESGVKRSYTFGPAGGGYEDPVQERERQSQSSSFTSTEVPEGAPVLSMLQPRQGALQGMQVRRVPLEMPEFDLDHESLQESQENTLMIEEKAKPKQYYRFWVLPGKWLRVRYDRLALLALLDRNRRVGENVFAVVLASLVAFLGFLLLLQGFFRDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWIIVYSRPVYFCLCCVMIWIFDLSGRSGSLQPFSLYGIIIFSAQFLLCVRDVLIVFALCFPVIFLFGLLPQVNTFVMCLLEQIDMHIFGGTATTSPLSSLYSLIRSVLVAALLYGFCLGAINAPWGDAHVPVLFSAFCGLLLALSYHLSRQSSDPTILWSLVRSKLFPELENRNPEEPPVEIKDPLPDKLRNSVKEILHSDLVICPLMAVITFAISASTVFIALQPALSVVLYILAGVVGFITHYLLPQLRKQLPWFCLAHPLLRSKEYSQFEVRDAAQLMWFEKLYAWLQCVEKYFIYPAVVLNSLTTEARTVGQNHKELDIYSRAFFISVAGMKLLRSSFCTPSQQYVTLCFTTLFFHYDYPHFSETFLIDYYFMSILFSKMWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAVLFVQAVFSAIFSTPLNPVLGSAVFVTSYTRPVKFWERDYNTKRVDHSNTRLATQLDRNPGADDNNLNSIFYEHLTRSLQHSLCGDLLLGRWGNYSTGDCFILASDYLNALVHIIEIGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGCCCCEPGHLPHMLSFNAAFGQRWLAWEVAATKYVLEGYSISDNNAASMLQVFDLRKILITYYVKSIIYYVSRSSKLEEWLTNETIQEALRPCLGSNYVDSDPTFNLNIDEDYDHRASGITPSSFCMVYLDWIQYCNSRRQTPVTCERDSPLVNLCFGLCILGRRALGTASHSMSASLEPFLYGLHALFKGDFRITSPRDEWVFADMDLLNRVVAPGVRMSLKLHQDHFTSPDEYEDPMVLFDAITANEEKMLISHEGDPVWRSAILANMPSLLALRHIMDDGSDEYKIIMLNKRFLSFRVIKVNRECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPIGYPIYVSPLTTSYAGEHSQLRSVWGGPVSPHNIYTWLISSWDRLQKGCGAGCNSGGNIEDSDCGGGSTSISTNPAVHTTQSTPASSLPQPHITTVQPSMGTDNPVGPTQSWHHHPQPLPLALLSQSEGRMEAGLLSSLQRTSSIQGLLGQQLSSSQLSFSSSVAPPPLPGPERFCPASLLESSGHRTGQRAGLGPGSGLHYESHFSKWSFSGRKGFNGPASTEGEGAPLQTIRTQPAPPASLQEAGLTQDPLGATQTTDPSPDPPTPREESTELPLLDHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRW6</accession>
    <name>A0A3P9CRW6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Exosome complex component RRP4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exosome component 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC4 and EXOSC7. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with GTPBP1. Interacts with ZFP36L1 (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538110.2">
        <property type="nucleotide sequence ID" value="XM_004538053.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CRW6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025095"/>
    <dbReference type="Ensembl" id="ENSMZET00005025913.1">
        <property type="protein sequence ID" value="ENSMZEP00005025095.1"/>
        <property type="gene ID" value="ENSMZEG00005018737.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101475682"/>
    <dbReference type="CTD" id="23404"/>
    <dbReference type="GeneTree" id="ENSGT00940000153596"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003407">
        <property type="term" value="P:neural retina development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009259">
        <property type="term" value="P:ribonucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021510">
        <property type="term" value="P:spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000022">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="14">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="16">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="15">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032383"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="293" mass="32627" checksum="C6CD7826ED97CBD9" modified="2019-02-13" version="1">MAADMRLPTIRKTVSLSASAFDRKDLVVPGDVITSDTGFMRGHGTYVDDDKLTASVAGEVQRVDKLICVRPLKTRFNGEVGDVVVGRITEVQQKRWKVQTNSRLDSVLLLSSVNLPGGELRRRSAEDELTMREYLQEGDLISAEVQSVFLDGALSLHTRSLKYGKLGQGVLVQLSPSLIKRQKTHFHNLPCGASIILGNNGFVWLYPTPGQQEEEAGGFYTSLEPVSLLDREVISRLRNCLLALAAHKVLLYDTSVLYCYESSLQHQVKDLLKPEVMEEIVMLTQQKLLEQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSG0</accession>
    <name>A0A3P9CSG0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zmp:0000001048</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSG0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025009"/>
    <dbReference type="Ensembl" id="ENSMZET00005025821.1">
        <property type="protein sequence ID" value="ENSMZEP00005025009.1"/>
        <property type="gene ID" value="ENSMZEG00005018666.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165414"/>
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        <property type="component" value="LG4"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006703">
        <property type="term" value="P:estrogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Estradiol 17-beta-dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011348">
        <property type="entry name" value="17beta_DH"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF1">
        <property type="entry name" value="RETINOL DEHYDROGENASE 8-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000095">
        <property type="entry name" value="17beta-HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000095-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000095-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="308" mass="34255" checksum="06746AB875BC5A32" modified="2019-02-13" version="1">MATRRVLVTGCSSGIGLAVAARLAKDELRRFKVVATMRDLGKRGPLEKAAGDSLNKTLEIKELDACCETSIKECINSLPNRRVDVLVNNAGVGMIGPLECQSIDAMKELFDTNFFGLVRLVKEVLPDMKQRQSGHIVVMSSVMGLQGLLFNDVYSASKFAVEGFCESLAVQAMKFNIKTTLVEPGPVVTEFERKMYESAEKMDLSGTDEETARIFRELYLPYSKEIFTSLSQTPEEVAEASVNVITAKDPPLRHQTNKVYMPMTALKHADPTGQLPLHTFYKMIFKHDRVFSATLGVLRLLQRRAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CU90</accession>
    <name>A0A3P9CU90_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FCH and mu domain containing endocytic adaptor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FCHO family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CU90"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025602"/>
    <dbReference type="Ensembl" id="ENSMZET00005026433.1">
        <property type="protein sequence ID" value="ENSMZEP00005025602.1"/>
        <property type="gene ID" value="ENSMZEG00005019101.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160489"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060028">
        <property type="term" value="P:convergent extension involved in axis elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000016">
        <property type="entry name" value="FCH domain only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF6">
        <property type="entry name" value="F-BAR DOMAIN ONLY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="9">
        <location>
            <begin position="579"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="823" mass="90269" checksum="FDE11180D4B93B56" modified="2019-02-13" version="1">MGTVLNLLSHKVCSPTIQFCVCLCFFHTTLSHGEKNAGFDVLYHNMKHGQLATKELAEFVRERAAIEETYSKSMSKLAKMASNGSPQGTFAPMWDVFRVSSDKLALCHLELMKKFNDLIRDINKYADEQVKIHRKTKEEMVGTVEAVQVLQVQSGQLQKSKEGYHAKCLELDRLRKEGGPQKELEKAELKSKKAAESFALCIEKYNRVGGEFEQKMSESAQKFQEIEEAHLRQMKQLIKGYSHSIEDTHVQVGQVHEEFKQNVENIGIDNLIQKFAEQKGTGKDRPAAVGFEEYMTALAPEGGKKSRAKAFRIPGLEFPLEVDDEGFVIREKETNFYSSDSDFDDEEPKKFHIQIRPVASSNRSSSVATEKELKATVGALTLPPNRGRSSQATSLPLSSTASGSDSLFGPPLESAFKSKSFDSRDQLRERSAFGASEYAAFSSDSSSPENVEDSGLDSPSHQPLGPSPEPAGWAAWPPASQSKEQTRGRPSDPFLSAFRDHSPGRSPHPQDTAEGVTAAPARATRAKRSSGRLGGCERSRSLCSSPLPEPNPSLTSSSSSSPMHLSRGPSPISLSTQEAWPVAAAITEYINAYFKGGQHNRCLVKITGDLTMSFPAGITRIFTANPNVPVLSFRLVNISKIDHFLPNQKLLYSDPSQSDPDARDFWFNMQALQLHLQREAEVNPQASYYNVGLFKYQVSSQDLGRAPLLLSAECQRSGTVTRVSLDYHCSDVTSLAVTDFKGSGLSCSLSLPCVDVIPGSGTLCASWQCLEVPRGPPPSLAVQFVGSGASLSGMDVELVGSRYRMSLVKKRFATGKYMAGCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVG1</accession>
    <name>A0A3P9CVG1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FAM20B glycosaminoglycan xylosylkinase</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557293.1">
        <property type="nucleotide sequence ID" value="XM_004557236.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004557294.1">
        <property type="nucleotide sequence ID" value="XM_004557237.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVG1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026064"/>
    <dbReference type="Ensembl" id="ENSMZET00005026903.1">
        <property type="protein sequence ID" value="ENSMZEP00005026064.1"/>
        <property type="gene ID" value="ENSMZEG00005019436.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473346"/>
    <dbReference type="KEGG" id="mze:101473346"/>
    <dbReference type="CTD" id="9917"/>
    <dbReference type="GeneTree" id="ENSGT00950000182951"/>
    <dbReference type="OrthoDB" id="8583677at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048701">
        <property type="term" value="P:embryonic cranial skeleton morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10470">
        <property type="entry name" value="FAM20B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF14">
        <property type="entry name" value="GLYCOSAMINOGLYCAN XYLOSYLKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017974893" evidence="9">
        <location>
            <begin position="23"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="FAM20 C-terminal" evidence="10">
        <location>
            <begin position="190"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR624869-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="409" mass="46035" checksum="62DDC17344DD3F31" modified="2019-02-13" version="1">MKLKQRMVVLCAVLLLLGLAKIFLLDGGEGTAASRRDLRAFRKMEAGLSLSRGARLTNTLQSSWEIASQWVGPREVYPEETPELAAVLTSLSSARIERADVGYKGTQLKALLVLDGGQKVVFKPKRYNRDYVVEGEPYAGYDRHNAEVAAFHLDRILGFRRAPLVVGRYVNLRTEIKPVATDQLLSTFLMQGNNTCFYGKCYYCRESEPACAEGEIMEGSLTLWLPDVWPLQKHRHPWGRTYREGKLARWEYDESYCEAVKKMPPYDAGPRLLDVIDTAIFDYLIGNADRHHYESFQDDGGASMLILLDNAKSFGNPALDERSILAPLYQCCMVRVSTWNRLNLLRSGALSSAMRQALAFDPIHPVLAEPHLAALDRRLSGVIETIKQCMEAQGPDNTLIEDRMNLPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CW93</accession>
    <name>A0A3P9CW93_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CW93"/>
    <dbReference type="Ensembl" id="ENSMZET00005027460.1">
        <property type="protein sequence ID" value="ENSMZEP00005026603.1"/>
        <property type="gene ID" value="ENSMZEG00005019839.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244843"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903037">
        <property type="term" value="P:regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF151">
        <property type="entry name" value="ICOS LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="186" mass="21000" checksum="6D72EF75CAF71739" modified="2019-02-13" version="1">MIPCTHCSLCLGTQIAQLQSPTLHSTSCEFDVVGSLQPILAAPGDDVILPCRVEPKFNVAGLTVEWSRPDRRPDPNDRLSRVEYVHLYRDAREVPDMKIPSYVGRTALFTDSLREGNISLRITNVTQEDEGRYRCFIPKLKSQIQSSIVHLIVGDRRISLCPVIFLESTTTILFAKFNLWDQTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CX70</accession>
    <name>A0A3P9CX70_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Nephronectin a</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nephronectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549482.1">
        <property type="nucleotide sequence ID" value="XM_004549425.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CX70"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026406"/>
    <dbReference type="Ensembl" id="ENSMZET00005027260.1">
        <property type="protein sequence ID" value="ENSMZEP00005026406.1"/>
        <property type="gene ID" value="ENSMZEG00005019704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468474"/>
    <dbReference type="KEGG" id="mze:101468474"/>
    <dbReference type="CTD" id="563273"/>
    <dbReference type="GeneTree" id="ENSGT00930000150973"/>
    <dbReference type="OrthoDB" id="10060424at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003171">
        <property type="term" value="P:atrioventricular valve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060347">
        <property type="term" value="P:heart trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000187">
        <property type="entry name" value="nephronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000476">
        <property type="entry name" value="nephronectin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000184">
        <property type="entry name" value="nephronectin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000268">
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        <property type="entry name" value="NOTCH1_EGF-like"/>
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        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="20"/>
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            <begin position="138"/>
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        </location>
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            <begin position="218"/>
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            <begin position="263"/>
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        <location>
            <begin position="472"/>
            <end position="616"/>
        </location>
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        <location>
            <begin position="323"/>
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        </location>
    </feature>
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            <begin position="352"/>
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            <begin position="391"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="623" mass="69118" checksum="BDBB6A4A78C7C2B1" modified="2019-02-13" version="1">MELWIKLMLLCSCSFGASADFDGRWPRQMASSNGLCRYGARVDCCWGWTRRSWGHCQPLFALTHRVVGIRCLPQAVCQPGCKHGDCVGPNKCKCHPGFTGKTCNQEEALDYLTPPVWASHLPIFLPVDHQPARVVMEDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGTCGNARTCGMANCQYGCEVLKGEVRCQCPSPGLQLAPDGRTCVDVDECAAGIAVCPRFRKCINTFGSYICKCHEGFDLQYINGKYQCIDVDECSLGQSHCSSFATCYNTPGSYKCKCKDGYRGMGHDCKPIPKVVIDPPRPGKVPPNHHNHIPDLDQQRTTTTRPPVTPKIIFPKLPPTATTTTKAPRPRVTPSQHKPLVPTRKPFIPTRKPFIPTRKPPVPTRKPYIPRPAVPTRPPLPLPPVTPVDNTIQKEVTKQRGDVHIPRNPSGNTVLDIDFDIELGNTADEAKDDPESGYLSCSFDDGLCGWIRDKDGDLHWETTPDPSGGRYLTIPEAGNKRTGRGARLVLPLIPPWNDGNLCLSFRHKLAGHHVGMLQVFVKKGKQYSPAVWGRTGGNGWRHTQITLWGTGLESVILKGERGRGRSGEMAVDDITLRKGSCTEEHNLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CXR1</accession>
    <name>A0A3P9CXR1_9CICH</name>
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        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <begin position="321"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="334" mass="35856" checksum="27BE4C16E565B1D6" modified="2019-02-13" version="1">MATAANSLEADRADGNGGEETVLEADRADGNGGEETVLEADRADGNGGEETVLEADRADGNGGEETVLEADRADGNGGEETVLEADRADGNGGEETVLEADRADGNGGEETVLEADRADGNGGEETVLEADRADGNGGEETVLGADRADGNGGEKAVLGADRADGNGGGNASLEAGHAEGSGGVQEGVHGGGDAQQAARQMTDDVEVVVGDLKAVWPLQPQVKRRPDQTRRTLMRRPDQARPKTLRPQQARTMKLQQARTMKLQQARTMRLQLARTMKLQQARTMKLQQAMRLQQVMRLQLMAGRNAQDRGTRKEKRKDKERRIEDKRNREKRQ</sequence>
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    <accession>A0A3P9CZT5</accession>
    <name>A0A3P9CZT5_9CICH</name>
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            <fullName evidence="4">Synapse-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">BSD domain-containing signal transducer and Akt interactor protein</fullName>
        </alternativeName>
    </protein>
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            <taxon>Eukaryota</taxon>
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            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
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                <person name="Russell P."/>
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                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
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                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
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                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts (via phosphorylated form and BSD domain) with AKT1; this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZT5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027885"/>
    <dbReference type="Ensembl" id="ENSMZET00005028773.1">
        <property type="protein sequence ID" value="ENSMZEP00005027885.1"/>
        <property type="gene ID" value="ENSMZEG00005020794.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3970.10:FF:000001">
        <property type="entry name" value="synapse-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF6">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="7">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00058614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00065448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="381" mass="44156" checksum="D77021D5DA3033BC" modified="2019-02-13" version="1">MKRRRNPLRAFLSMTTTTTDGRLAQTRWDNDSRKWNWSSWLGAEKESGQVTEEPADANEEKRFSEINKPSDQQGRDAGTDAQLLQKAKGFSGYIYNFASSASKKLSESVVETAQTLKKSVEEGKISGIIDKTILGDFQKEQERFVQEKRAKEYGAAVPLWVGYNEEDAIQEQILALSADKRNFLRDPPAGVQFYFDFDQMYPVAMVMLEEDELLRKMRFHLVPKQVKEEVFWKNYFYRVSLIKQSAQLTALAAQQAAEWIDVKKTSYPCKDPHQNDAVKSKASSLQPKSSEDEEELSTSLQLSEFVSDTFDSCEINKDDLCKEMRELVLDKRENLNPEQEEMPDWERELQEELREYDVLADSETHDDNWDKEIEEMLKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZU0</accession>
    <name>A0A3P9CZU0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase/reductase (SDR family) member 13b.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004572843.1">
        <property type="nucleotide sequence ID" value="XM_004572786.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZU0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027341"/>
    <dbReference type="Ensembl" id="ENSMZET00005028213.1">
        <property type="protein sequence ID" value="ENSMZEP00005027341.1"/>
        <property type="gene ID" value="ENSMZEG00005020399.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475537"/>
    <dbReference type="KEGG" id="mze:101475537"/>
    <dbReference type="GeneTree" id="ENSGT00940000155599"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF51">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE (SDR FAMILY) MEMBER 13-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018128649" evidence="4">
        <location>
            <begin position="17"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="317" mass="34900" checksum="74E7AE79784D49EC" modified="2019-02-13" version="1">MCLLLVLGLAIAVAYFYREIVVKGKRCTSKAKLHGKTVIVTGSNTGIGKTTALDLAKRGARVILACRSKQRGEAALEEIKRDSGNNQVVFMQLDLGSLKSVRSFAENFLKSEPRLDILINNAGVQMQGRTADGLGLMFGVNHIGHFLLTNLLLEQLKACGPSRVVNVSSMAHYFGKIDFDCLNTHKALGLGTSFMEVLQYYSDSKLCNYLFTHELAKRLKGTNVTCYSLHPGAINSELARNINSTLQLFLKPLTAYFFKNTEQGCQTTLHCALQEGIEPFSGRFFSNCTVKEVSDKAKDDAASKKLWELSERLCGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1I2</accession>
    <name>A0A3P9D1I2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="19">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58433"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:43485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="19"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1I2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028219"/>
    <dbReference type="Ensembl" id="ENSMZET00005029117.1">
        <property type="protein sequence ID" value="ENSMZEP00005028219.1"/>
        <property type="gene ID" value="ENSMZEG00005021037.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156180"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120548">
        <property type="term" value="F:phosphatidylinositol phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904088">
        <property type="term" value="P:positive regulation of epiboly involved in gastrulation with mouth forming second"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901232">
        <property type="term" value="P:regulation of convergent extension involved in axis elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007223">
        <property type="term" value="P:Wnt signaling pathway, calcium modulating pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13363">
        <property type="entry name" value="PH_PLC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000088">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000058">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000022">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF31">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="13 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PH" evidence="20">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="23">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="22">
        <location>
            <begin position="487"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="603"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="752" mass="86406" checksum="9CB99990D810AA79" modified="2019-02-13" version="1">VDKPQSSQGDDNLQAMLVGAMMRKIKSRNWKKQRYFKLEDDFMTIWYQSKKAGNVRSTFSVNDVEAVREGHQSEVLLSIADEFPPDRCFTLVFRGRRGNLDLVAESAEEAQSWIWGMRKLIENVENMGEREKLDQWIGEWFKKADKNNDGRMNFKEVQDLLKMMNVDMNEHHAHHLFTMADKSQSGTLENDEFVLFYKMLTQREDVLKVFQEYSVDGQKLSQSNLEDFLREEQLEGDDIQLHAKQLIECYEPSDKAKRMNAMTFDGFLMYLGSAEGSIFNPQQRGIFQDMTQPLCHYFISSSHNTYLMEDQLRGQSSVEGYIRALNRGCRCVEVDCWDGANGEPIVYHGHTFTSKILFKDVVSAVGNYAFKVSQYPVILSIENHCSVEQQRVMAHHLNHILGDRLLKTILDGKAPIRLPSPEDLKGKILVKAKKDGGLEQSLSGMVEDSLNGEVSDDDEAAEIDEDHPHHESIHCRLKSKQRLSKELSDCVVYCKSVHFTSFKHSRIHSKFYEVASFTESKARKHLRDAGAEFVHHNSRQLSRVYPSGFRTDSSNFNPQEMWNAGCQIVALNFQTAGEGMDVNDGLFSQNGCCGYVLKPSFMREADVRFDPEMPQKRDHYHPVVLTVQVISGQQLPKVNIKEDSIVDPLVRVEVHGVPMDQAKQETRYIENNGFNPMWYDTLHFTIHTPELAMVRFVVEDYDKTSKNDFVGQYTLPLSCMQQGYRHIHLLSKDGTSIPPSSLFVYLRIKHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1X0</accession>
    <name>A0A3P9D1X0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="11">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>phosphocholine + CTP + H(+) = CDP-choline + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18997"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.7.7.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:18998"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004546634.1">
        <property type="nucleotide sequence ID" value="XM_004546577.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1X0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028578"/>
    <dbReference type="Ensembl" id="ENSMZET00005029483.1">
        <property type="protein sequence ID" value="ENSMZEP00005028578.1"/>
        <property type="gene ID" value="ENSMZEG00005021312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479032"/>
    <dbReference type="KEGG" id="mze:101479032"/>
    <dbReference type="CTD" id="100001552"/>
    <dbReference type="GeneTree" id="ENSGT00940000156040"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="UniPathway" id="UPA00753">
        <property type="reaction ID" value="UER00739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000016">
        <property type="entry name" value="Putative choline-phosphate cytidylyltransferase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF20">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="14">
        <location>
            <begin position="68"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="303"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="361" mass="41406" checksum="FDBD10C00AE358C4" modified="2019-02-13" version="1">MVKQRRVRAHSSCAPVAPFCRRRGSLKTLTEPAIFANETSCDCRAPHEKLTIAQACKGTPVDRPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHKYKGFTVMTEHERYEALRHCRYVDEVLRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSEDVYKHIKEAGMFVPTQRTEGISTSDLITRIVRDYDVYARRNLQRGYTAKELNVSYINEKKYRLQNQVDRMKEKVRTVEEKSKHFVYRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGTWKQVFQERSGRMLSYALSPRESPSNSPPRELSPLRSPSPPSPPARWHNARPSPPTSPKGASASISSMSEGDEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1Z3</accession>
    <name>A0A3P9D1Z3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Caspase 9, apoptosis-related cysteine peptidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1Z3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028630"/>
    <dbReference type="Ensembl" id="ENSMZET00005029535.1">
        <property type="protein sequence ID" value="ENSMZEP00005028630.1"/>
        <property type="gene ID" value="ENSMZEG00005021345.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159698"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048696">
        <property type="term" value="P:regulation of collateral sprouting in absence of injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:renal filtration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08326">
        <property type="entry name" value="CARD_CASP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Caspase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042147">
        <property type="entry name" value="CARD_CASP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF157">
        <property type="entry name" value="CASPASE-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038001">
        <property type="entry name" value="Caspase_ICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="CARD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="10">
        <location>
            <begin position="142"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="9">
        <location>
            <begin position="317"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038001-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="406" mass="45480" checksum="74C634EDE41D69D5" modified="2019-02-13" version="1">MDEIHKNILQRNRSNLVKDLDPSKLYDGLLEKGIFTQDMIDEIQSAGTRRNQARQLVQDLETRGSRAFPLFLQCLQETGQESLAELLQNGAPAVTLQPATPTQVVRPVIQPLPFSKSPGGGKPGPGRVRRDSLQGYKMDASPCGYCLIINNMEFEPHSMLKNRKGSNIDCEKLERRFKTLNFVVEVRTNLRQKQIKHELLTLSKKDHSQYDCCVVIMLSHGTEVNHNRFPGAVYGVDGQYVPVQHITNYLNGQHCPSLQGKPKLFFIQACGGDERDMGFEVSPDEVEPSSGGMDDQTDAIPMSSSSDSLSMSDEPDARPTLPTPSDILVSYSTFPGYVSWRETQSGSWYVQTLDCILEENAATVDLVTMLMMVNNEVSQNSAKGLYKQMPGSFNFLRKLLYFRTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D286</accession>
    <name>A0A3P9D286_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat domain 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004562721.1">
        <property type="nucleotide sequence ID" value="XM_004562664.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004562722.1">
        <property type="nucleotide sequence ID" value="XM_004562665.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D286"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028464"/>
    <dbReference type="Ensembl" id="ENSMZET00005029368.1">
        <property type="protein sequence ID" value="ENSMZEP00005028464.1"/>
        <property type="gene ID" value="ENSMZEG00005021225.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474436"/>
    <dbReference type="KEGG" id="mze:101474436"/>
    <dbReference type="CTD" id="91875"/>
    <dbReference type="GeneTree" id="ENSGT00390000006227"/>
    <dbReference type="OrthoDB" id="423589at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032076">
        <property type="entry name" value="TTC5_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038645">
        <property type="entry name" value="TTC5_OB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16669">
        <property type="entry name" value="TTC5_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 5 OB fold" evidence="2">
        <location>
            <begin position="323"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="444" mass="49358" checksum="F18F70867914B4CC" modified="2019-02-13" version="1">MAEEEKSGEAVENKDELQIMKELVDELYKFRDCYFETHSVEDAGRKHSDVAEEMAQTLKKLEEKEDAFKHKAEFLLQKGRCLNVAPDFSAAAEECLSRAVKLQPGLVEGWNTLGEQYWKKGDLIGAKNCFTGALQQSKNKVSLRNLSMVLRQLPAADNDAHGKQVLESVDMARQAVQLDVKDGTSWYILGNAYVSLFFTCGQNPQLSQQALSAYTQSETVDRAASCYPELHFNRSTLFQYEEMYGSALAGYSRAAELDPGWKEPPEREKQLLEYLEKVTELLQNKGKVKARRLRTMLSNLNTSALGPCSSPQFRSPAGRVGSLEPRTLSSLTHGHNAGVAALGKVVFSLASEGRMAFTFGMVDSEETCIVVMVYNTADSWGVLIGDSVVIPEPQVKRHSITHKDKSLDFRSIRVDSPLLLIVNGKKQNVKSQIAASVSYKPQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D359</accession>
    <name>A0A3P9D359_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymethylenebutenolidase homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dienelactone hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D359"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028642"/>
    <dbReference type="ESTHER" id="9cich-a0a3p9d359">
        <property type="family name" value="CMBL"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005029547.1">
        <property type="protein sequence ID" value="ENSMZEP00005028642.1"/>
        <property type="gene ID" value="ENSMZEG00005021355.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000183"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000178">
        <property type="entry name" value="Carboxymethylenebutenolidase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042946">
        <property type="entry name" value="CMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46812">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46812:SF1">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="239" mass="27267" checksum="F2E2966A42C68488" modified="2019-02-13" version="1">MANEAKPCPCDIGDRMEYGALGQEVQMEHFKAYVVKPSTASDKAIVVIQDIFGWQLPNTRYMADMLAANGYMSICPDFFVGKEPWSPTKDWSNFQEWLQDKKEVDAVLKFLKNQCGAKHIGVVGFCWGGVATHYLALLYPEIKAGVSVYGIVREREDRYELKSPTLFVFAENDSVIPLDQVSALEANLKEKCKVDYQVKIFPGQTHGFVHRKREDINPADKPYIQEARKDLLNWLNTYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3Z2</accession>
    <name>A0A3P9D3Z2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Si:dkey-19b23.13</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3Z2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029074"/>
    <dbReference type="Ensembl" id="ENSMZET00005029992.1">
        <property type="protein sequence ID" value="ENSMZEP00005029074.1"/>
        <property type="gene ID" value="ENSMZEG00005021674.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156128"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000003">
        <property type="entry name" value="Calpain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000114">
        <property type="entry name" value="Calpain a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF405">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="4">
        <location>
            <begin position="83"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="441" mass="51027" checksum="6EBBC82D11E66381" modified="2019-02-13" version="1">RFSCMKEICDRLEILYKDPPFPSTDQSLFYKRQPPPGLSWQRPRVSCRTLAPPGPLTTTSRQRVRCLAQGHNDRGCPSQGSNRLNGCYEALEGGNTAEALIDFTGGVSEPLSLNHEALRLHSDQRRALCQTLTKVHEYKSLITCSIRGETVESVLECGLVRGHAYGITAVRKVRLGEKVLKRGGTSRLFMVRMRNPWGTTDWTGAWSQRSEQWQQLSRAERDKMGLVVRAVGEFWMDFEDFCQHFTDVVVCRLVERTLLWPRSRWREVSCYGEWLDKRSRCGGCINHRDTFLHNPQFMFEVRAKEEEVLICLQQEDRRMWRKNGKGENLPIGFEVLKVEVNRCSRVQCVVEQAASSIYMDSRSVTLRGTLTLGRYVVLPTTFLLRLFSHSRIRLRTSNCHDHCFEQKDDFTLMTPLVIQPYLHFMLQSFLLSQIFNISLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D505</accession>
    <name>A0A3P9D505_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A</fullName>
            <ecNumber evidence="17">2.4.1.145</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-{alpha-D-Man-(1-&gt;6)}-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-{alpha-D-Man-(1-&gt;6)}-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69631"/>
            <dbReference type="Rhea" id="RHEA-COMP:17739"/>
            <dbReference type="Rhea" id="RHEA-COMP:17740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:187880"/>
            <dbReference type="ChEBI" id="CHEBI:187881"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:69632"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16057"/>
            <dbReference type="Rhea" id="RHEA-COMP:13526"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60651"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="EC" id="2.4.1.145"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16058"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69635"/>
            <dbReference type="Rhea" id="RHEA-COMP:17741"/>
            <dbReference type="Rhea" id="RHEA-COMP:17742"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:187882"/>
            <dbReference type="ChEBI" id="CHEBI:187883"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:69636"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = an N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69615"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="Rhea" id="RHEA-COMP:17732"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:187873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:69616"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = an N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-Gal-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69627"/>
            <dbReference type="Rhea" id="RHEA-COMP:17737"/>
            <dbReference type="Rhea" id="RHEA-COMP:17738"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:187878"/>
            <dbReference type="ChEBI" id="CHEBI:187879"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69628"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = an N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69619"/>
            <dbReference type="Rhea" id="RHEA-COMP:17733"/>
            <dbReference type="Rhea" id="RHEA-COMP:17734"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:187874"/>
            <dbReference type="ChEBI" id="CHEBI:187875"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:69620"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;6)]-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-[alpha-L-Fuc-(1-&gt;6)]-beta-D-GlcNAc}-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69623"/>
            <dbReference type="Rhea" id="RHEA-COMP:13532"/>
            <dbReference type="Rhea" id="RHEA-COMP:18198"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137207"/>
            <dbReference type="ChEBI" id="CHEBI:187877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:69624"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 54 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.145" evidence="17"/>
    <dbReference type="RefSeq" id="XP_004551368.1">
        <property type="nucleotide sequence ID" value="XM_004551311.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D505"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029745"/>
    <dbReference type="Ensembl" id="ENSMZET00005030680.1">
        <property type="protein sequence ID" value="ENSMZEP00005029745.1"/>
        <property type="gene ID" value="ENSMZEG00005022186.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470408"/>
    <dbReference type="KEGG" id="mze:101470408"/>
    <dbReference type="CTD" id="11320"/>
    <dbReference type="GeneTree" id="ENSGT00940000159177"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008454">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF4">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
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            <dbReference type="Pfam" id="PF23524"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="533" mass="61263" checksum="1769AD29DCB36142" modified="2019-02-13" version="1">MRLRNGTVATALIFFTSFLSLSWYTAWQNGKEKLIAYQREFHALKERLRVAEHRTLQRSSELNNILEQFRRAIAETNSSKDALTNFSDETQKLLKELANRKPLQVPNIYHHLPHLLNNEGSLHPAVQVGLGRTGVTMVMGIPTVKRKVKSYLSETLRSLIDKLSPEEKLDCVIIVFVGETDLEYVHSVVAGLEKEFSTELSSGLLEVISPPASYYPDLNNLKETFGDSKERVRWRTKQNLDYSFLMMYAVSKGVYYVQLEDDIVAKPNYFATMKNFALQLSSEDWMILEFSQLGFIGKMFQAPDLNLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCERQKSSLRVRFRPSLFQHVGLHSSLAGKIQKLTDKDFLKPLLHKMHVNPPAEVSTSMKVYQGHTLEKTYLGEDFFWAITPTAGDYILFKFDRPVSIERFLFRSGNQEHPGDKIENTTVEILPVSESGLQTKDKYKRTEDRFYRIGQFEKGVAEGAVDPSLNPVVALRLSVLKDSAVWAILSEIHIKRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6D0</accession>
    <name>A0A3P9D6D0_9CICH</name>
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        <submittedName>
            <fullName evidence="4">Junctional adhesion molecule 2b</fullName>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="JUNCTIONAL ADHESION MOLECULE 2 PRECURSOR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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            <end position="249"/>
        </location>
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        <location>
            <begin position="16"/>
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        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="288" mass="31584" checksum="025C799FC9FEBD0E" modified="2019-02-13" version="1">MKMLALPLLITILHSPVSLSVTVSSSKPKVEVHEHTDAVLSCEFKTEKDQNPRIEWKKKGKGVTFVYFNHKFTGSYAGRAKIEGATLTIHSVTQKDSGEYRCEVTASEDHVNLGEATVTLNVLVPPHVPSCNVPSSVFVGSGLELLCKDKLSVPPATYRWYKDNKALTATGETPYSIDTNKGTLKFKSVSKVDAGMYRCESSNSVGAPKSCVAQQLKVIDYPLNMTILIAGAAGLAAFMLFCCICVCVCRHRGCCKKSKKTKSTKSYNPPPPPTRNLKHYKQTQSFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6Q9</accession>
    <name>A0A3P9D6Q9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SPARC-like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPARC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549572.2">
        <property type="nucleotide sequence ID" value="XM_004549515.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6Q9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030360"/>
    <dbReference type="Ensembl" id="ENSMZET00005031313.1">
        <property type="protein sequence ID" value="ENSMZEP00005030360.1"/>
        <property type="gene ID" value="ENSMZEG00005022624.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101467363"/>
    <dbReference type="CTD" id="8404"/>
    <dbReference type="GeneTree" id="ENSGT00510000046787"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000068">
        <property type="entry name" value="SPARC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000004">
        <property type="entry name" value="SPARC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015369">
        <property type="entry name" value="Follistatin/Osteonectin_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001999">
        <property type="entry name" value="Osteonectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF25">
        <property type="entry name" value="SPARC-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09289">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00612">
        <property type="entry name" value="OSTEONECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00613">
        <property type="entry name" value="OSTEONECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018276546" evidence="11">
        <location>
            <begin position="17"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="13">
        <location>
            <begin position="447"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="218"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="657" mass="74467" checksum="98285694CDFB9E1B" modified="2019-02-13" version="1">MKACLVFLCLLAATFALSVKSKPHGKHHGLHKSLHTTKEKDAITVEANKPKILPTLVTFEASSQEQEDEELSSEDNANKEDGERAEKREKSTAVLLSEEELVDLLTKEAEEEDEAEVRELEEEEVEADKAKVESSEVVEVAEDQEKLDENSETKKHLLDEEEVKEDSVEDVIEEKVQKMTHSERKEEPTEALLEEDGSTESVIPVNLDYAADSSLLQPLQTASANDKIHSDDTKPTSKTDIREKETSGKEMANIADDYEPGMQNTEAAHSEEVSDQTQDKDSSDQDVSAKKEPEANVDHPEPKDDAELELRATLSGKEEEKSKNVGASHTKAKTRKQKKNQTSRKHSPDREETQPGQEEGRQDPESESSSTDNTDQKTKRRRAGKWGPLVGVNPVQIRAAAELYPRSRPSLGGDIQLPETPTDPCENFRCKRGKTCKLDADNKPGCVCQEPSECPPSVNEFDYVCGTDNKTYDTSCELFATKCNLEGTKKGHRLHLDYTGPCKLIPPCVDNERVQFPLRMRDWLKNVLLQLYEHDSITPGFLTPKQRFRVKKIFESERRLHAGNHSVELLAQDFEKNYNMYIYPVHWQFAQLDQHPSDRFLSHSELAPLRVPLVPMEHCTSRFFQECDADKDKLVSFKEWITCFDIRNEDMDANLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAM2</accession>
    <name>A0A3P9DAM2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium voltage-gated channel, Isk-related family, member 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel KCNE family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAM2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031152"/>
    <dbReference type="Ensembl" id="ENSMZET00005032157.1">
        <property type="protein sequence ID" value="ENSMZEP00005031152.1"/>
        <property type="gene ID" value="ENSMZEG00005023231.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013776"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902282">
        <property type="term" value="F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097623">
        <property type="term" value="P:potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000369">
        <property type="entry name" value="K_chnl_KCNE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15282">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15282:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02060">
        <property type="entry name" value="ISK_Channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00168">
        <property type="entry name" value="KCNECHANNEL"/>
    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="195" mass="21614" checksum="997CC1FC2DF2CA2E" modified="2019-02-13" version="1">MEIFFFFRSPIQKLHLKMEHSENSTASPKRLVLHAQSTGEDKSDGNAYLYILIVMSFYGVFVCAIMLGYFRSKRREKRRVNIFTRLVHEEEQREWGALPKKHSLSCPAAASGLRSMQVSLPFYNNHGGHFGNLHYESALACVLCTEQSSISSLCSSADTRLTIEEESDSGTAEGPAEGPEESAKPGTENSGDDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAZ8</accession>
    <name>A0A3P9DAZ8_9CICH</name>
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        <recommendedName>
            <fullName evidence="9">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="gene ID" value="ENSMZEG00005023768.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
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        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="SRCR-like domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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            <end position="28"/>
        </location>
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    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DC48</accession>
    <name>A0A3P9DC48_9CICH</name>
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        <submittedName>
            <fullName evidence="6">Ecotropic viral integration site 5 like</fullName>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
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                <person name="Venkatesh B."/>
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                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_004539260.4"/>
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        <property type="gene ID" value="ENSMZEG00005023936.1"/>
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    <dbReference type="CTD" id="115704"/>
    <dbReference type="GeneTree" id="ENSGT00940000153846"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000002">
        <property type="entry name" value="Ecotropic viral integration site 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000002">
        <property type="entry name" value="Ecotropic viral integration site 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000003">
        <property type="entry name" value="Ecotropic viral integration site 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF12">
        <property type="entry name" value="ECOTROPIC VIRAL INTEGRATION SITE 5 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="150"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="789"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="395"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="472"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="856" mass="97561" checksum="4B9E4DAB0EC89F02" modified="2019-02-13" version="1">MSIPSGSPEREGSGGAPPQLECPSSPPGMDPDPSSNGSPVLSPDSSSHDAVLSAPAASPADSENLSPDELELLAKLEEQNRLLEADSKSMRSMSGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIVNEWEEWRRKKDKLLKELIRKGIPHHFRAIVWQLLGNATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYLLQEQLPELNVHFRSQSFHTSMYASSWFLTLFLTFLPLPVATRIFDIFMYEGLEIIFRVGLAILQYNQTDLIQLDMEGMSQHFQKVIPHQFDSCPDKLILRAYQVKYNPKRMKKLEKEYTTIKNKEMEEQIEIKRLRTENRLLKQRIETLEKESAALADRLIQGQVTRAQEAEENYVIKRELAVVRQQCTTASESLEKAQDTIRELQQRRYTEQFVSNLQTELEQSRLREAELLGALKEMQDKVLDLEKRSSCLPDENNLATLQEEVKQMKLRELETLRSFREMQEAVTELNQRWQHHMSRSSSTGGGGGHWKESPKKNAMNELQDKLMTVRLREAQAQAELREVKLKALQLESQNQIHSKLIGRNEQERSALQDRLQMVANQNKALQAQLNEMKRKQAESDCKSKEEVMAVRLREADSMAAMAELRQKIAELEIQKEEGLIQGQLNHSDSRQYINQLRDQIAELKNEIRQLRGQKVTPSSRVTSGGGSTNYQDLCLASPASAEGDFLSSDEDLLPSPLPATALYPSLSGQCHPSPRLDSEGSTDSEAEERVQTHPDPQQLYGSIVCAEALDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCF1</accession>
    <name>A0A3P9DCF1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UTP6 small subunit processome component</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCF1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032049"/>
    <dbReference type="Ensembl" id="ENSMZET00005033086.1">
        <property type="protein sequence ID" value="ENSMZEP00005032049.1"/>
        <property type="gene ID" value="ENSMZEG00005023895.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016493"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:003652">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001123">
        <property type="entry name" value="UTP6 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056907">
        <property type="entry name" value="UTP6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24892">
        <property type="entry name" value="UTP6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 homolog C-terminal" evidence="7">
        <location>
            <begin position="306"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="597" mass="70208" checksum="538FFCF471714D1F" modified="2019-02-13" version="1">MAEIVQQRIEDRIPELEQLERVGLFTKKEVKSIIKRVTALEYKLHRLIVNKEDFIAYIQYEINVLELIKKRRAHIHYQFKREEIEYPIIHRINSIFKRATNKWKDDVQLWLSHVAFCKKWATKSQISKVFSAMLAIHPDKPALWIMAAKSELEDRNSSESARHLFLRALRFHPNDKKVYQEYFRMELLHCEKLRKQKIQLEQAQMDLGEYEFSPEILSGKLAEVVYKDATGKIKEAEFVISLLNIAAIFDFTKDLQDSILQDLQTNYTDDSSTWDFMAKRELEAPGAGEELQTAKGRASDINRREERCCQVYEEGVKSLNTEPMWTCYVAFLLERMKRKTNVQELKEKRQERLLGVLQRAHDCSLLKENYYKNWLQILLSSGDAEGAASVAMTATQRYSQSVTMWSLSLQTLMELGSRDIGRCFQDALKHVNPKESLPLWQLQFEWSKASQSAEETEAILKRGLLSAVPAVAMEMKECYLDWSYSTGGYKKARKTFTSLQENRPLSKEFFTRMIQIEKEQVHTIRLRTFRFFVFFKHNCFLFRFSKDLWLQYIREELGPLGQPENCGKIHWRAMKFLEGESVERFISKHALLQTGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCX7</accession>
    <name>A0A3P9DCX7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase ZNRF1</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase ZNRF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc/RING finger protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004555262.1">
        <property type="nucleotide sequence ID" value="XM_004555205.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCX7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032540"/>
    <dbReference type="Ensembl" id="ENSMZET00005033594.1">
        <property type="protein sequence ID" value="ENSMZEP00005032540.1"/>
        <property type="gene ID" value="ENSMZEG00005024241.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469748"/>
    <dbReference type="KEGG" id="mze:101469748"/>
    <dbReference type="GeneTree" id="ENSGT00940000166346"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000235">
        <property type="entry name" value="E3 ubiquitin-protein ligase ZNRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="260" mass="28357" checksum="AB3BB679E40E8970" modified="2019-02-13" version="1">MGTRTSRLHEDTVSSAFGKDGTKRDSCRRPRCTRPTSLVVDFSVSFDDTEANRSRSEEGSDSDPGQLGASADGSPADHHSIPSSIGQASPGDDDSSEGKPEEDGNVSPEAPVDAEHQQVEETGRTPHRTFSERLPGNRHSATRVGARSARVRSTHQRPVSEAWIGLYRLNNRHGNIRCPFCSKPFPGGRIEDHLLSCLTSPPLPYNTDVLSKDSGECSICLEDLVQGETIARLACLCVYHKSCIDSWSKVKPCCPEHPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDE4</accession>
    <name>A0A3P9DDE4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Collagen IV NC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DDE4"/>
    <dbReference type="Ensembl" id="ENSMZET00005033582.1">
        <property type="protein sequence ID" value="ENSMZEP00005032528.1"/>
        <property type="gene ID" value="ENSMZEG00005024233.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24254" checksum="9A434FD9BDD9C47E" modified="2019-02-13" version="1">PLLFTTLLQSIEVCKRLFMHSSLKPHSHVFLLGRPGTLGEVGPSGQDGPRGVLGPSGPKGEKGHLGLKGPSGPKGDKVGASDLYVGCNLFFPLNVIRSLSGHLVNPLKPMGVLVLGQTFRSKETLRSNYNLSSCPYYPSLCRVTLVSRAAEDHRDWMAVTGPEEILEIPALGGDTLAPVDFLYGKTSCFIHLTYFNLTYSNTSNIIFTYRDRDTDVVFASNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDU8</accession>
    <name>A0A3P9DDU8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">GTP-binding protein Rheb</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Ras homolog enriched in brain</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Small GTPase that acts as an allosteric activator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. In response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change that allows the alignment of residues in the active site of MTOR, thereby enhancing the phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1). RHEB is also required for localization of the TSC-TBC complex to lysosomal membranes. In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1. Has low intrinsic GTPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Associates with the mTORC1 complex (MTOR, MLST8 and RPTOR) in a guanyl nucleotide-independent manner. Interacts with TSC2. Interacts with MCRS1; the interaction maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB. Interacts (when prenylated) with PDE6D; this promotes release from membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Lipid-anchor</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555338.1">
        <property type="nucleotide sequence ID" value="XM_004555281.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DDU8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032668"/>
    <dbReference type="Ensembl" id="ENSMZET00005033727.1">
        <property type="protein sequence ID" value="ENSMZEP00005032668.1"/>
        <property type="gene ID" value="ENSMZEG00005024338.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464515"/>
    <dbReference type="KEGG" id="mze:101464515"/>
    <dbReference type="CTD" id="6009"/>
    <dbReference type="GeneTree" id="ENSGT00940000165403"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
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    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
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    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00093480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="184" mass="20631" checksum="A39CC4B29DBC466C" modified="2019-02-13" version="1">MPQPKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKMITINGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSNKSFEVVQVIHEKLLDMVGKVQVPIMLVGNKNDLHMERVISCEEGKALAESWNAAFMESSAKENQTAVEVFRRMILEAEKMDGGVQPGKTSCSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDX0</accession>
    <name>A0A3P9DDX0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell adhesion associated, oncogene regulated</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004560547.1">
        <property type="nucleotide sequence ID" value="XM_004560490.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DDX0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032357"/>
    <dbReference type="Ensembl" id="ENSMZET00005033401.1">
        <property type="protein sequence ID" value="ENSMZEP00005032357.1"/>
        <property type="gene ID" value="ENSMZEG00005024108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479466"/>
    <dbReference type="CTD" id="50937"/>
    <dbReference type="GeneTree" id="ENSGT00940000157114"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070121">
        <property type="term" value="P:Kupffer's vesicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045879">
        <property type="term" value="P:negative regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000205">
        <property type="entry name" value="Cell adhesion associated, oncogene regulated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF1">
        <property type="entry name" value="CELL ADHESION MOLECULE-RELATED_DOWN-REGULATED BY ONCOGENES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018210109" evidence="6">
        <location>
            <begin position="26"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="117"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="218"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="312"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="451"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="593"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="696"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="930"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1122" mass="121676" checksum="059DDE46BC77C831" modified="2019-02-13" version="1">MDSGLRVLLSTVLCLSQSLLITCSSQYPSFHSEPASLVQSQGSVVHLQCSVSPPSAVVSWRFRGLPLDRDTLPGVELGSGSLTISSLMPSHAGVYQCVARLDHGPAIASRYARVAIAEISKYEDGQRRSLSVQEGSTALIECPLPRSIPPAIPRLRIQGGWVEASKDDYLILPSGNLQIISVSAQHQGMYKCGAVNPVTKETVIQSHGTKLSVKYSDPSSSVQIVYPKTPKTVSIEKSQPLTLECVVSGSPAPAAKWFKNGKVIPGPSHQRQHNNLAFVGAMRSDEGSYTCAVETEQGTLVSANYTVKVLEPVSIIEGPGNQLASLGSSARFICVAQGNPSPNITWLFNAEPITPSHRFQISGSSLVVSDVTRQDEGVYQCLLDNGFSSAQSFGMLTTQGDSQSGSTVGALPEASPSLHPIQGDEGHERLLTENEGDPINLPADRSSNRPTPEAPIIISPPQTHKPDVYDLEWKAGRDGGNPINAYFVKYRKVDEMGTVVGSWHTVRVPGSEKTLRLSELESLSLYEVLMVARNSAGEGQPAMLTFRTGKEKSTSPNKNPSKPPVISVPPKAPEDKTPNTHFGVVIHDRVPEAPDRPTISMATESSAYVTWIPRANGGSPITAFRVEYRRGRSAEWVVAADNISPLKLSVEVRNLEPGSTYKFRVAAMNMYGESPHSIPSKPYQVPQTSPPKTDRPVVGPHISSTDAISDTQIMLRWTYSPSTNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGIKNWHMIGHLQPETSYDIKMQCFNDGGESEYSNVMICETRARQSPGSPSQHPITPSDPHPVDTPSPPGGLLYVIVGSVLTVMVFILVSFIIICLWRNRQQNNMHKFDAPGYLYQSPELNGHVLDYTTLPGNSRVNGGIHSGYGHSGQMLPQGCHHLHHKLPNGLALLNGSGNLYTPGPPHGHNGTLPHSTRDCEHSHPHHHHNGGGMYTALPQTESSDCMSCQNLCNNNRCYNKTNGTFSSGTLPLMHRVAPCQQDGLEMVPLGQVSSQCRGHDSHTHSVDQEANAGYRSDEHKESSPSQHSCCLISNNETYLADNTAGEEPECVDTEGPVVGWESLGLPDLDCDEKPGWISSSSLAGELIQPGPQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEE2</accession>
    <name>A0A3P9DEE2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="20">PARP</shortName>
            <ecNumber evidence="20">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of a base excision repair (BER) complex, containing at least XRCC1, PARP1, POLB and LRIG3. Homo- and heterodimer with PARP1. Interacts (via the PARP catalytic domain) with HPF1. Interacts with core nucleosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="20"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DEE2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032537"/>
    <dbReference type="Ensembl" id="ENSMZET00005033591.1">
        <property type="protein sequence ID" value="ENSMZEP00005032537.1"/>
        <property type="gene ID" value="ENSMZEG00005024239.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158452"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08003">
        <property type="entry name" value="WGR_PARP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000003">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 20" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WWE" evidence="22">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="25">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="24">
        <location>
            <begin position="294"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="23">
        <location>
            <begin position="420"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="641" mass="72253" checksum="06B3FDCF6DCD5C75" modified="2019-02-13" version="1">MRRARSSRNKCESAPENGEAQSKTVWQWMGDKRQWESYSPSACAVLDSAVSSGKTSVTLSLGSGTAYEVDLKKMVQINPVTKYKRKVRCQNVKAAGDVATHNEKPAQVKEEEEDTEEQPAAKKRRGQSKSQTKTEEMPKKAKEEVKKVVKTVVMKGKAPVDSECKAKLGKAHVYNEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDSSKVYSVWMRWGRVGKVGQNSLTVCGGDLLKAKDVFKKKFFEKTKNEWEHRDSFEKVAGKYDMVFMDYSTNEKEENQTTVDTVPKKKTSELDSRIQSLLELICDLKAMEECVLEMKFDTKKAPLGKLTPEQIRAGYSALKKIEDCLKKKKGSSRDLLEACNQFYTRIPHDFGLKTPPLIQTEEELKAKIALLEALSDIQIAVKMVKSSEDSDEHPLDRQYHSLRCKLQPLDSSNNEYKVIEQYLHTTHAPTHCDYTMTVLDIFSVDRDGEKILLLTLLWHGSRLSNWVGILSQGLRVAPPEAPVTGYMFGKGIYFADMSSKSANYCFSNQNNNVGLLLLCEVALGESNELLDADYEANNLPAGKHSTKGLGQTGPDHKNSVTLDGMTVPMGPGVKTGVGKSNAYSLLYNEFIVYNPAQTRMRYLLRVKFNYSSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DG32</accession>
    <name>A0A3P9DG32_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DG32"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033096"/>
    <dbReference type="Ensembl" id="ENSMZET00005034199.1">
        <property type="protein sequence ID" value="ENSMZEP00005033096.1"/>
        <property type="gene ID" value="ENSMZEG00005024687.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163467"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="100"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="318"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="492" mass="55609" checksum="6B29C16B82DF11AA" modified="2019-02-13" version="1">MEEKRRKNYVCSAKEEFQEGTEVSCSTEAAPTPEGSRGRGRSQMTCPPAKRGKRSRSLSGDAAAWMSEKNPDSLPHPLLNFCPKRKPGVQLPFSESKNIAAGKKFTWTDLPEAELYHYIGITLYMGVLKLPKMRDFWRVNSIFHVQYPSEVMTRDRFLTITWNIHMSDPAEDTLNDRKKGTTDYDCLHRLRPLYDSLRVSYKAVYHPQQNLSVDERMVSTKARVVLKQYIKSKPTKWGIKLFVLSDNTGYTVDFNIYTGRSTLVTGKGLSFDAVMALINKNYLGTGYHIYCDNFYTSPALFHHPHDGFGACGTWIREGSLIFIKWMDTREVSVCSTLHSAFSGDTVKRMCKVEGQHRAIEVPVPSADQLIGSYSSWRKSRKWYVTVLHHFIDIAVTNSYLVSKELCGRLEQRPMTHQDFQEQLITELCGVSSQSGAKSYQHIPVAIVEGASGQNKATKGHRKCRLCGKCTPFKCEACKVALCVISHCPASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIG7</accession>
    <name>A0A3P9DIG7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIG7"/>
    <dbReference type="Ensembl" id="ENSMZET00005035399.1">
        <property type="protein sequence ID" value="ENSMZEP00005034198.1"/>
        <property type="gene ID" value="ENSMZEG00005025561.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177152"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029383">
        <property type="entry name" value="ARL6IP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28640">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28640:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15062">
        <property type="entry name" value="ARL6IP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="121" mass="14076" checksum="C20E0EE11EDE7EC7" modified="2019-02-13" version="1">MRKSNWNTVEHVNKCLCVYACVFHRRRWKVSLIVPGESKQNHKGWFLCALIYPILKELRAERVTGEDGTEEKMLGFWSLLVLSVLVGCICCVFSWMFTYLDSFQPGMDFPTLWTGAHVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK51</accession>
    <name>A0A3P9DK51_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase TRIM39-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_024657075.1">
        <property type="nucleotide sequence ID" value="XM_024801307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DK51"/>
    <dbReference type="Ensembl" id="ENSMZET00005035775.1">
        <property type="protein sequence ID" value="ENSMZEP00005034562.1"/>
        <property type="gene ID" value="ENSMZEG00005025815.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:112432878"/>
    <dbReference type="GeneTree" id="ENSGT01040000240400"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19802">
        <property type="entry name" value="Bbox1_TRIM8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF32">
        <property type="entry name" value="BLOODTHIRSTY-RELATED GENE FAMILY, MEMBER 16 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="349"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="190"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="565" mass="64007" checksum="6AA71C8B09F93527" modified="2019-02-13" version="1">MSAASNLRSEDQFLCSICLDVFTDPVSTPCGHNFCKTCISQHWDMNQSCQCPMCKETFYTRPQLRVNTFISEMVAQFRREAQQKASSSSSEQQAAKPGEVPCDVCTGTRLKALKSCLVCQTSYCQTHLEPHLTLKGLKRHQLVDAVENLEGRMCTKHDKLLELFCKTDQTCVCMLCSVLDHKNHEFVPLREEYEGKKAELEKTEAEIQQMIQKRRLKIQEITESVKMSKDAADRQKAEGVQVLTALMESVERRLKELMKEIEDKQEATEKQAEGLIKDLEQEISELMERSSEVEQLSRSEDHLHLLQSFSSLKAAPPSKDWTEVRVRPPSYEGTVGRAVAQLEETVWKPMKKKLFEAELQRVQQHEVDVTLDPDTAHPTLILSDDGKQVYDSDVRKNLPDNPERFSLCVCVLGEQSFSSGRFYFEVQVKGKTKWVLGVATESINRKGKITARPQDGFWTVWLRNGNEYKAAADPSVRLCLHPGPEKVGVFVDYEEGLVSFYDVGAAALIYSFTGCSFTHKLHPFFCPCTNDGGKNSAPLIICPVNNINRPLISFVELLDFCFDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DKT9</accession>
    <name>A0A3P9DKT9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gypsy retrotransposon integrase-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DKT9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034807"/>
    <dbReference type="Ensembl" id="ENSMZET00005036047.1">
        <property type="protein sequence ID" value="ENSMZEP00005034807.1"/>
        <property type="gene ID" value="ENSMZEG00005026023.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244855"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="101"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="285" mass="31396" checksum="65A3E3EC277ADF81" modified="2019-02-13" version="1">PGRPCPSVNKNGPRAGGHPGVGRRSAPSLRRFHRPPRPVVPLSWRRRVFDSVHALSHPGVRASVKLVSARFVWPGLRKTVKEWAAVCIPCQRSKIHRHTQAPLEPFRVPGRRFDHVHVDLVGPLPQSQGFTHLLTVVDRTTRWPEAVPLASTTAATVARAFLSTWVSRFGPPADITSDRGPQFVSELWSAMADGLGVKVHRTTAYHPQANGMCERFHRSLKAALRASLTSGDWVERLPWVLLGLRSAVKEDLGVSAAELVLGQPLRVPGEFLPESPPPCFDTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DL36</accession>
    <name>A0A3P9DL36_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Microphthalmia-associated transcription factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546337.1">
        <property type="nucleotide sequence ID" value="XM_004546280.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DL36"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035114"/>
    <dbReference type="Ensembl" id="ENSMZET00005036360.1">
        <property type="protein sequence ID" value="ENSMZEP00005035114.1"/>
        <property type="gene ID" value="ENSMZEG00005026253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473787"/>
    <dbReference type="CTD" id="114833"/>
    <dbReference type="GeneTree" id="ENSGT00940000156326"/>
    <dbReference type="OrthoDB" id="6242697at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18926">
        <property type="entry name" value="bHLHzip_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000003">
        <property type="entry name" value="microphthalmia-associated transcription factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
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    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR021802">
        <property type="entry name" value="MiT/TFE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF4">
        <property type="entry name" value="MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11851">
        <property type="entry name" value="DUF3371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="301"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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            <dbReference type="ARBA" id="ARBA00023159"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="513" mass="57277" checksum="0028FDC8E4030257" modified="2019-02-13" version="1">MQSESGIVPDFEVGEDFQEEPKTYYELKSQPLKNSSPSDQHSSSKPPLSSSAMTSRILLRQQLMREQLQEQERREQQRQQASQYTQTTQAQTPAINVSVPVSLPPAAQVPMEVLKVQTHLENPTKYHIQRSQQQQVKRYLGKLGSQALSLPCPNQSSDHGGMPPGPGNSAPNSPMALLTLNSNCEKEMDDVIDDIISLESSYSDDILGLMDPGLQMANTIPVPANLIDMYGNQGMPQQGLPISNSCPANLPNIKREYSVSQSPAIMHMLDKSGSCGKFDTYQRPEGFPVEAEVRALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQKKLEHANRHLMLRIQELEMQARAHGLAIASSALCSAEIGVRTIKQEPALEDCHQDLYTLHPHHQQHPACTPETPSNLELNEGHSNFSEGHYGVHSKSGSKLSDILMEDTLSPVRGGDPLLSSVSPDTSKDSSRKSSVSMDENEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLE6</accession>
    <name>A0A3P9DLE6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ICOS ligand</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004543934.1">
        <property type="nucleotide sequence ID" value="XM_004543877.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLE6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035580"/>
    <dbReference type="Ensembl" id="ENSMZET00005036837.1">
        <property type="protein sequence ID" value="ENSMZEP00005035580.1"/>
        <property type="gene ID" value="ENSMZEG00005026585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474078"/>
    <dbReference type="GeneTree" id="ENSGT00530000067879"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF2">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN CD86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="298" mass="33270" checksum="7A5894BC3242EC86" modified="2019-02-13" version="1">MMASTWSRYHFLTQRFSLDLLLSLVLTLTWPFTVTGGAAILKGEVGGNVTFHCSGKSVKNIDLLYLQRDNVFVNGYYESKKVPATWNNTKFDRNTSSVFMDNLKVSHSGEYKCHIRYKDEQHINEDSITLSVTAKYSRPLFSPPVCSEETQNCQTTCTSNNGYPESSMIVQAIVTSTNETIRQIWQHVKSVSSPNPSTFLYNITTAVSYNCSNGEIKFSCSVGDVTSDEFSVCAHQDQRSSDIVIMTAICILVVVVVMIAGVLCWRRRTGGSMRLERVNTNEAVEISLCEKNGEKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DN89</accession>
    <name>A0A3P9DN89_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Collagen type XIV alpha 1 chain</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.</text>
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        <property type="protein sequence ID" value="ENSMZEP00005036265.1"/>
        <property type="gene ID" value="ENSMZEG00005027050.1"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
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    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:interstitial matrix"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
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    <dbReference type="CDD" id="cd01482">
        <property type="entry name" value="vWA_collagen_alphaI-XII-like"/>
        <property type="match status" value="2"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000489">
        <property type="entry name" value="collagen alpha-1(XII) chain isoform X1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000444">
        <property type="entry name" value="Collagen alpha-1(XIV) chain isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Collagen type XII alpha 1 chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="3"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000480">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.410:FF:000001">
        <property type="entry name" value="Collagen, type XII, alpha 1"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
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    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF15">
        <property type="entry name" value="COLLAGEN ALPHA-1(XIV) CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="vWA-like"/>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017927021" evidence="12">
        <location>
            <begin position="21"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="13">
        <location>
            <begin position="115"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="311"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="402"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="493"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="586"/>
            <end position="678"/>
        </location>
    </feature>
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        <location>
            <begin position="683"/>
            <end position="774"/>
        </location>
    </feature>
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        <location>
            <begin position="775"/>
            <end position="865"/>
        </location>
    </feature>
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        <location>
            <begin position="983"/>
            <end position="1156"/>
        </location>
    </feature>
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            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
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        <location>
            <begin position="1421"/>
            <end position="1447"/>
        </location>
    </feature>
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            <begin position="1497"/>
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        </location>
    </feature>
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        <location>
            <begin position="1561"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="953"/>
            <end position="968"/>
        </location>
    </feature>
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            <begin position="1510"/>
            <end position="1524"/>
        </location>
    </feature>
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        <location>
            <begin position="1525"/>
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        </location>
    </feature>
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        <location>
            <begin position="1571"/>
            <end position="1580"/>
        </location>
    </feature>
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        <location>
            <begin position="1587"/>
            <end position="1598"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022530"/>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023278"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1615" mass="176416" checksum="7EF65E5E78A18F93" modified="2019-02-13" version="1">FICLLCKAVYWFFLCLVSSPRRLRTKVLSPTKLHVSWKEPKGQFESYKVIYTTRPEQKVVQASKQEAKLVIEDFDPSKTYNFKIIAVHEGQESKPLQGKHEAEAGFMCKTPAIADIVILVDGSWSIGRINFRLVRTFLENLVKAFSVEIDKTRIGLAQYSGDPRIEWHLNAHTTKESVIDAVKNLPYKGGNTLTGLALTFVLENSFKPESGSRPGVPKIGILITDGKSQDDVIPPAQSLKDAGIELFAIGVKNADENELKAIASPPEETHVYNVADFSVMSDIVEGLTKTVCDRVEQLDKKIKGLKTVVAAPRDLVTSEITARSFRVTWTHASGQVEKYRVVYYPASGGQPEEKVVQGTQNSVELSYLNSLTEYQVAVFAVYRSAASEALRGSATTLALPTVNNLELFDITHSTMRVRWKAVAGASGYMILYAPLTEEDASDEKEVKVDDSVTEVELEGLTPATEYTVTVYAMYGEEASDPMTSQQTTLPLIPARNLRFSEVDHSSARITWDSASRKVKGYRIMYVKTNGVQTNESLIIGPASVHSWLLKNLTSLTEYTVGVFAVYDEGQAEVVTDSFTTKTVPDPVDLRSSDISTNSFRVSWAHPASDVVLYRLTWTPTDGEESSEVLVNGNINTYLIKELTPSTEYEVLLAAIYGNELESDEVILVESTVSLSNPSAPRYGVRSMKIDEETTFSMRVSWQPVDPRNARHYRLSYISARGDRAAETRTVPTGQNSLVLQPLLSDTEYKVSITPVYPEGDGPAAAATGRTLPLLAPRNLRVSEEWYNRFKISWDVPPSPTMGYRVIYQPLTAPGQALETFVGEDVNTMLIVNLLSGTEYSVKVIASYSTGSSEALTGRAKTLYLGVTNLSTYQVRMNGLCAQWQPHRHASAYRVALESAVGSQKQETRLSGGASRHCFNNLKPNMQYKISIYAQLQDGTEGPAVTTAEKTLPVPTPPPTKPPTTTPPPTIPAAKEVCKAAKADLVFLVDGSWSIGDENFLKIIRFLYSTSGALDRIGPEGTQVAIAQFSDDARTEFKLNSYSDKEGLLDAINKISYKGGNTKTGRAIQHVKKNIFTEEAGARRGIPKVLVVLTDGRSQDDVNKVSKEMQMEGYIVFAIGFADADYGELVSIASKPSDRHVFFVDDLDAFKKIEEKLVTFVCEAATATCPAVPMSGSTMPGFRMMELFGLVENRYSSMSGVSMVPGTFNTFPCFHLHSDALLAQPTRYIHPEGLPSDYTITLLFRLLADTPEEPFALWEILNKNNEPLVGVILDNGGKTLTFFNNDFKGEFQTVTFEGPEIKKLFFGNFHKLHLAISKTSAKVFVDCKMVSEKTVNAAGNISTDGLEVLGRMVRSRGNKDNSAPFQLQNFDIVCSTSWANRDKCCELPSLVRSKSEAVSMFACLKQEEMTWKLLSAHLHTGPTGPVGDTGLPGPQGPPGRQGPSGRSIIGPPVGYTVFNNLLVFFGDLQSTASVQAIARQVCEQLIQSHMARYNSILNHVPSPPVSIRTVPGPPGEPGREGPPGPQGEQGPPGRPGFPGQNGQNGQPGERVLFSKLFILFLPGPQGQGRPGSSGPSGRPGNPGVPGRPGAPGPIGPQGPPGYCDQNSCVGYNVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DP93</accession>
    <name>A0A3P9DP93_9CICH</name>
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        <submittedName>
            <fullName evidence="15">6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesis and degradation of fructose 2,6-bisphosphate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567620.1">
        <property type="nucleotide sequence ID" value="XM_004567563.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DP93"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036052"/>
    <dbReference type="Ensembl" id="ENSMZET00005037322.1">
        <property type="protein sequence ID" value="ENSMZEP00005036052.1"/>
        <property type="gene ID" value="ENSMZEG00005026900.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469149"/>
    <dbReference type="KEGG" id="mze:101469149"/>
    <dbReference type="GeneTree" id="ENSGT00950000182835"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
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        <property type="term" value="P:fructose metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
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        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
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        <property type="entry name" value="6Pfruct_kin"/>
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        <property type="entry name" value="6Phosfructo_kin"/>
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        <property type="entry name" value="His_Pase_superF_clade-1"/>
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        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
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    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="11">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="255"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="468" mass="53457" checksum="DB1A3C3010BD156F" modified="2019-02-13" version="1">MMNGERIAAAGGDTPGAAGRTLRFQRPHASVPQFTNSPTMIVMVGLPARGKTYISTKLTRYLNWIGVKTKVFNVGQYRRQATCSYNSYQFFRPDNEEAMKIRKACAVAALQDVCEYISREQGQVVVFDATNTTQDRREVILNFAKENGYKVFFVESICDDPDIIAENIKQVKLSSPDYAGCDKEEAVADFLKRIECYTMTYVPLDDTKDRNLSYIKIFNVGSRYLVNRVQDHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLVGRIGGDSGLSSRGAKFASTLGTYMRGQCISDLKVWTSHMKRTIQTAEALGVQYEQWKALNEIDAGVCEEMTYEEIQEHFPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSANELPYLKCPLHTVLKLTPVAYGCKVESVFLNIEAVNTHRDKPVNVDVDRDPAEALETVPEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPK5</accession>
    <name>A0A3P9DPK5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DPK5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036167"/>
    <dbReference type="Ensembl" id="ENSMZET00005037441.1">
        <property type="protein sequence ID" value="ENSMZEP00005036167.1"/>
        <property type="gene ID" value="ENSMZEG00005026987.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177111"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF31">
        <property type="entry name" value="IM:7152348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="126" mass="14422" checksum="203E2B21A885980F" modified="2019-02-13" version="1">MVTAEELECCVCCYEYSRSNRIPRVLHCNHTFCAPCLERMSKLEGAIYTVSCPLCRWITCTRASLTLPGALWVNTEIWDQISTEQNQNENHSMEDLKDPKSLLIEHSLSSGFPPRQRSHQVYGVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ44</accession>
    <name>A0A3P9DQ44_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 39B</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_023009423.1">
        <property type="nucleotide sequence ID" value="XM_023153655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ44"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036256"/>
    <dbReference type="Ensembl" id="ENSMZET00005037530.1">
        <property type="protein sequence ID" value="ENSMZEP00005036256.1"/>
        <property type="gene ID" value="ENSMZEG00005027045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479187"/>
    <dbReference type="CTD" id="55116"/>
    <dbReference type="GeneTree" id="ENSGT00390000018895"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019397">
        <property type="entry name" value="Uncharacterised_TMEM39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 39B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10271">
        <property type="entry name" value="Tmp39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="489" mass="56005" checksum="A6F297CF436DFBB6" modified="2019-02-13" version="1">MAGGRRGANRTTYCRPPLSSDSGSVGNGNHTTSSPVTGVRSRTSRNSPGTCMSSPPLAAQTVVPLKHCKIPELSMDQNVLFELHLFFCHLIALFVHYVNIYKTVWWYPASHPPSHTSLNFHLIDYNMLVFTIIILARRLIAAIVKEASQSGKLSFPHSIFLVMARFAVLTLTGWSLCRSLIYLFRTYSVLSLLFLCYPFGMYIPLFRLSCDFRRAVPLSPITSIGSKEVGGVGRGRDYLTVLKETWKQHTSQLYGVQAMPTHACCLSPDLIRKEVEYLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFVKSTQYVDKRWSCELFILVSVSTSVILMRHLLPPRYCDLLHKAAAHLGCWQKVDPSLCSNVLQHIWTEEYMWPQGVLVKHNKNVYKAMGHYNVAVPSDVSHYRFYFFFNKPLRILNILIILEGAMIFYQLYSLICSEKWHQTISLALILFSNYYAFFKLLRDRIVLGKAYSYSNNSSDHKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRG7</accession>
    <name>A0A3P9DRG7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glial cell line-derived neurotrophic factor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TGF-beta family. GDNF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547360.1">
        <property type="nucleotide sequence ID" value="XM_004547303.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRG7"/>
    <dbReference type="Ensembl" id="ENSMZET00005038157.1">
        <property type="protein sequence ID" value="ENSMZEP00005036868.1"/>
        <property type="gene ID" value="ENSMZEG00005027475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471543"/>
    <dbReference type="KEGG" id="mze:101471543"/>
    <dbReference type="GeneTree" id="ENSGT00950000182993"/>
    <dbReference type="OrthoDB" id="9950038at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030116">
        <property type="term" value="F:glial cell-derived neurotrophic factor receptor binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007422">
        <property type="term" value="P:peripheral nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090190">
        <property type="term" value="P:positive regulation of branching involved in ureteric bud morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000015">
        <property type="entry name" value="Glial cell line-derived neurotrophic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043401">
        <property type="entry name" value="GDNF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173">
        <property type="entry name" value="GDNF SUBFAMILY OF TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12173:SF1">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018151075" description="Glial cell line-derived neurotrophic factor" evidence="12">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="13">
        <location>
            <begin position="141"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="271" mass="29897" checksum="7ADB1BC0C0DE9BD9" modified="2019-02-13" version="1">MKLWDSLTTCLILLSAVYASPLLQSPQQPTSTKRRGRVAESPPELPPAQIGLSVSSTSMSRADTANRDETLAGGDKYTTEEPLPNEFEDVVNFIKVTISRMRRSSSLTVSSSTSTTSTTAAAVPISSPSKDNFDSRTRHRRRKRKRTSQRNSNRREGGSRGAGAGGKIRGGGRGQGCVLKQIHLNVSDLGLGYRSSEEMIFRYCSGPCRKSETNYDKILYNLIHNRRLPAKDVPPQACCRPIAFDDDLSFLDDSLVYHTVRKHSARRCGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSS1</accession>
    <name>A0A3P9DSS1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCF1 rRNA-processing protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
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        <property type="entry name" value="PIN domain-like"/>
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    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="99" mass="11634" checksum="0B87405801F1B30E" modified="2019-02-13" version="1">MMDCLYAKCKYTIYTDCVMAEIEKLGMKYRVALRIAKDPRFERLPCTHKGTYADDCLVQRVTQHKCYILATIPGVPIMYISNHRYNIERMPDDYGAPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DT54</accession>
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        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="FC RECEPTOR-LIKE PROTEIN 4"/>
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        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
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        <location>
            <begin position="209"/>
            <end position="284"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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            <dbReference type="PROSITE" id="PS50835"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037639.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="293" mass="32198" checksum="D7AD97A48F6D09BE" modified="2019-02-13" version="1">QSDAFSFPVTSTANEPRPVLTVSPSWLSPGASVTLNCEVEHPSAGWSFYWYKAVADLSEKSSSYELLPDGSGTAQDSYIIHGQTHTAGYVCRAGRGDPEYHTDHSQPKFVWSAGQFDSVYPASLTVSPDRVQHFTSDSVSLTCEGNFPEWRVRKFSEDARLYSVCRRMTGSTCNINTSESDTAVYWCESGSGEFSSAVNITVQNDGNGPILVSPVHPVTEGASVSLSCSLRTQKILSNVFFYHNDKLIQNDTRGELKISAVSKSDEGFYKCQYSGRESAQSWMSVKGEQDQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTE5</accession>
    <name>A0A3P9DTE5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enkurin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
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        <subcellularLocation>
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        </subcellularLocation>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
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        <location>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037406.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="247" mass="29413" checksum="33890C6B4848EE53" modified="2019-02-13" version="1">MYISKYREAIVLENKYKNEHRTMVPRTVKAPSHREMCPQRPEGEKPEHTFRKKPEHTGMKKVMAQPACVDTRKGDKQLLEKSGLVPFYLQKNDYRIVPGYLRRRKAEKEKAKQDNDAWLTKQQETVKPLAEQEKQNILQGLKRRFNELNFEYQSLPFTISPSQHKKYNYKMFLEEAMSQVEKDIALFEEHKYIYVGREDASDEQHYENNSLNMFVAFTVKMTSIFYSDLNFFCLNLDLLCKYSINEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTN2</accession>
    <name>A0A3P9DTN2_9CICH</name>
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        <submittedName>
            <fullName evidence="17">G protein-coupled receptor 161</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Cichlomorphae</taxon>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 161"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_1"/>
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    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="54"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="492" mass="54149" checksum="CB760434384BBBBD" modified="2019-02-13" version="1">MPSPQHPPPFFTSPVAQLLTMNTSRNCTTVGNGEGLAALESVSIVTITLLACLGNFLIVATLYRRPYLLTPSNKFVFSLTLSNLLLSVLVLPFVAVSSAKREWMFGVVWCNFTALLYLLISSASMLTLGAIAIDRYYAVLYPMIYPMKITGCLPPLFGWSSFEFDCFKWTCVASWHREPSYTAFWVTWCILPPFFIMWRVTPAKFTVGLLLLAQDDSTGAQRNGRKNSSTSTSSNGSRRITILVVIGTFLMTWGHTWGGGTEALWGQGSVSQWVETLVAWLSFCSAVCHPLIYGLWNKTVRKELLGMCFGDRYYRESFATRQRTSRLFSISNRITGGTIAGLSLLAPGSSTGDTGFSSLRTHVSTDVMLLDNFSTDGSSLAQHHGPPSGKRRSSVTFEDQVEHSKAENTSSVQIHAEVHKSLDMFASCLAKAIESDAKLTLFGESSALSAGLLTARAAPRPRYLEGQRLRLESIDEGIVKDDRAAEKAVIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTY7</accession>
    <name>A0A3P9DTY7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTY7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005038210"/>
    <dbReference type="Ensembl" id="ENSMZET00005039643.1">
        <property type="protein sequence ID" value="ENSMZEP00005038210.1"/>
        <property type="gene ID" value="ENSMZEG00005028596.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155200"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000128">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="84"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005038210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="618" mass="69140" checksum="99B297751EB6C028" modified="2019-02-13" version="1">MEEVRLFFCRLKLVESRDTLHAILSLKLRGGICMRRDCLSWHLVFAKSPIVVMCIKTTMKSNAKLNFWFSMSVLFLCVATQLRAPVVHTKLGSLKGEYVSVKGKETGVHAYLGVPFAKPPLGPSLRLAPPQPAERWEGVRYATKQPPMCIQPERFALALLDKLGFLLADIPDISEDCLYLNIYTPAKRADDAQLPVMVWIHGGGLTVGSASTYDGSALAAYQDVVVVLIQYRLGLLGFLSTGDEHISGNFGLLDQIEALRWIQQHIHSFGGDPGLVTIFGESAGGVSVSLLLLSPLSDGLFHHAIAESGTAAMDLLVENYPLLKEVSNASGCSLKSTKTFADCIRSLDIDTIVDFTKDRRLRCPVNVDGHFLTKPVDELFRKHELLTVPFMMGVNNDEAGWMLKNLFISVPQNWAEGMDRAQVINAMAFFYPNPKDAFIKNLIIDEYIGNGANRVKNRDGFSEVTADIIFNIPVIKTANAHREAGAPVYLYEYQHSLKMVQKRRPSFVGSDHTDEIFTVMGFCFTTTHVKLPHPCFVEEEQLSRTMMSYWGNFARTGSPNGHDLVHWPKYEADEKYLAIGLTTQVTAQHLKKERFVFLTQTVPEKLKRHEENAKRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2000-05-01" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q9PUE9</accession>
    <name>Q9PUE9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Opsin 1 (cone pigments), short-wave-sensitive 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19">Putative ultraviolet sensitive opsin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="20">SWS1 opsin</fullName>
        </submittedName>
    </protein>
    <organism evidence="19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2000" name="Vision Res." volume="40" first="879" last="890">
            <title>Visual pigments of African cichlid fishes: evidence for ultraviolet vision from microspectrophotometry and DNA sequences.</title>
            <authorList>
                <person name="Carleton K.L."/>
                <person name="Harosi F.I."/>
                <person name="Kocher T.D."/>
            </authorList>
            <dbReference type="PubMed" id="10720660"/>
            <dbReference type="DOI" id="10.1016/S0042-6989(99)00238-2"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="19">Retina</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2011" name="BMC Evol. Biol." volume="11" first="120" last="120">
            <title>Divergence in cis-regulatory sequences surrounding the opsin gene arrays of African cichlid fishes.</title>
            <authorList>
                <person name="O'Quin K.E."/>
                <person name="Smith D."/>
                <person name="Naseer Z."/>
                <person name="Schulte J."/>
                <person name="Engel S.D."/>
                <person name="Loh Y.H."/>
                <person name="Streelman J.T."/>
                <person name="Boore J.L."/>
                <person name="Carleton K.L."/>
            </authorList>
            <dbReference type="PubMed" id="21554730"/>
            <dbReference type="DOI" id="10.1186/1471-2148-11-120"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF191219">
        <property type="protein sequence ID" value="AAF05730.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JF262085">
        <property type="protein sequence ID" value="ADW80523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_001297003.1">
        <property type="nucleotide sequence ID" value="NM_001310074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9PUE9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020537"/>
    <dbReference type="Ensembl" id="ENSMZET00005021204.1">
        <property type="protein sequence ID" value="ENSMZEP00005020537.1"/>
        <property type="gene ID" value="ENSMZEG00005015119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474256"/>
    <dbReference type="KEGG" id="mze:101474256"/>
    <dbReference type="CTD" id="30582"/>
    <dbReference type="GeneTree" id="ENSGT01030000234549"/>
    <dbReference type="OrthoDB" id="6142583at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000018">
        <property type="entry name" value="Rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001521">
        <property type="entry name" value="Opsin_blue"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00574">
        <property type="entry name" value="OPSINBLUE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9 17" id="KW-0157">Chromophore</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
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            <begin position="47"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00002881"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004951"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAF05730.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ADW80523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="335" mass="37383" checksum="0BAA8C6B3C56E6ED" modified="2000-05-01" version="1">MGKHFHLYENISKISPFEGPQYYLAPVWAFYLQAAFMGFVFFAGTPLNFIVLVATMKYKKLRVPLNFILVNISFSGFIFVTFSVSQVFLASMRGYYFLGHTLCALESAVGSVAGLVTAWSLAVLSFERYLVICKPFGAFKFGSNHALAAVAFTWFMGIGCACPPFFGWSRYIPEGLGCSCGPDWYTHNEQYNTTSYTHFLMVTCFIIPLSIIIFCYSQLLGALRAVAAQQAESASTQKAEKEVSRMIIVMVGSFVTCYGPYALAALYFAYSTDENKDYRLVTIPAFFSKSACVYNPLIYVFMNKQFNGCIMEMVFGKTMDESSEVSTKTEVSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARM7</accession>
    <name>A0A3P9ARM7_9CICH</name>
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        <submittedName>
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        <lineage>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
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                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005000350.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:extrinsic apoptotic signaling pathway via death domain receptors"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ISR_Activator"/>
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            <end position="219"/>
        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="514" mass="56824" checksum="390E2E39EA32C16A" modified="2019-02-13" version="1">MWRLHGFVGRVLHRYHGNSTLRLSQNHHVEDEVINSSAVLSTSRHSPDNRSQEEEDGERRRKQRTFQSKYAEFPRYTALDAVGWGAAAVLFMQLCRRIHSQFSSSTEPSPSPGALSALSTLHNCGYHILLEILSRHDVLPRGRNVLCLQGVLERQNQDQSPTQSSDSDSSSTQDQLTAISDHQRELLIQDTLIPEDEFLSASCPLQDDASQDKAEKPDTSDEEMLSDEERLAAAALNLRRVEDVCVPVVLNIIGLENAKRENHQEAFTCFLAAAQQGYSKAQFNVAVCYEKGRGVSKNKEKALHYYRQAAASGHRQAQYRCAKLLLTSRGHQSPEELSTAIDLLEQAAAAGLTKAQLSLASIYAQDTVKYGCKSIQNLEMAAESGDDTAQLFLGNCYESGFVVQQNLRTAIKFYKQAARAGNKQAERLLRPPNETYTKESVLRSIHSAPCFSKTFSPLSSCVTPSTSQPTALPLLPHSWSTGSLSGLPSLSSVPLHLHSPSTERRSCQWTVGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AT02</accession>
    <name>A0A3P9AT02_9CICH</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540348.1">
        <property type="nucleotide sequence ID" value="XM_004540291.2"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005000753"/>
    <dbReference type="Ensembl" id="ENSMZET00005000826.1">
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        <property type="gene ID" value="ENSMZEG00005000686.1"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47728:SF1">
        <property type="entry name" value="RAB GTPASE ACTIVATING PROTEIN 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47728">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="353" mass="40649" checksum="ECC639ED044B13C7" modified="2019-02-13" version="1">MMEEVSMVNAYDAHAIEQMSEEEIFACLESETGPKFTVPTKKAKLKECRLQIMDDEEDTLDKYVKENRQLQQASLRLEQENDNLAHKLITSKVALRNTLDKVEDRVDELTKDLMETRQQLQITEEEKRGKEEEAAMLKEVFRREIEKAEQKLKRSSGIIADYKQICSQLTNRLESQQAAHREEMDSLKSAIKACSHCQHIMNSDETSDIGRDSETAAQTEDQKVTEQGVEEKDEDPTLEEQRRREQEKELLRAQIGELEKELVQTKLQMVEATCKIQELEHQKGILTSDLQEAKNSWISKAFTSLRTSSEGLHSLNIHKAGTHTMGWNVHSASLSGWSPKKLSWPHRVNRENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVE3</accession>
    <name>A0A3P9AVE3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVE3"/>
    <dbReference type="Ensembl" id="ENSMZET00005001774.1">
        <property type="protein sequence ID" value="ENSMZEP00005001681.1"/>
        <property type="gene ID" value="ENSMZEG00005001368.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154725"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003836">
        <property type="term" value="F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097503">
        <property type="term" value="P:sialylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051757">
        <property type="entry name" value="Beta-gal_alpha2-3_sialyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46032">
        <property type="entry name" value="ALPHA-2,3-SIALYLTRANSFERASE ST3GAL I ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46032:SF6">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="136"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="328" mass="37831" checksum="8D9C04472863D062" modified="2019-02-13" version="1">MYLFSDWNSANMYFKWGRSRVSIFPLLSITAIVLVSNLLWSFSGYTFCHREPSLCGCQKCLRDSDPWFNDIISEAPEPFLSQKHIPSEKDFLWWKNLQGARLQNLTLYNKTLERLFQTITPIADIGEPRPDHCRSCAVVGNSGNLRGSHYGPLIDSHDIVIRMNRGRTKGYERDVGTKTTHHVMYPESSTRLDNTTHLLFFPFKTRDFLWLMKDINRGENGAPNLKKIANKDLIWILHPAFMKYVHQEWLGKKGAYPSTGFLAVVLSLVMCDEVTIFGFGADSGGSWSHYFEIFKNKKFKTGAHPGADEYKMIEKLHKKKTIVFFKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVV2</accession>
    <name>A0A3P9AVV2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVV2"/>
    <dbReference type="Ensembl" id="ENSMZET00005001642.1">
        <property type="protein sequence ID" value="ENSMZEP00005001552.1"/>
        <property type="gene ID" value="ENSMZEG00005001275.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230338"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047196753" description="C-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="155" mass="18054" checksum="2BEED3B9C9F9B379" modified="2025-10-08" version="2">MLCLFLLMGLITLVLLCKYNRNIISMPKSSQAMHVFYDDVSNISSEPKSWEESRQNCRQKGADLMIINSREEQNFVNQFKKHLWIGLTDSETEGTWKWVDGTQTTTSYWNQGNKEPNGGTWQNCGEIDNYNIEDSWNDAPCSNRQFWICEKRVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AW06</accession>
    <name>A0A3P9AW06_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="27">Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death.</text>
    </comment>
    <comment type="function">
        <text evidence="28">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle</location>
            <location evidence="7">Autophagosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6 28">Preautophagosomal structure membrane</location>
            <topology evidence="6 28">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 28">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004540372.1">
        <property type="nucleotide sequence ID" value="XM_004540315.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AW06"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001809"/>
    <dbReference type="Ensembl" id="ENSMZET00005001904.1">
        <property type="protein sequence ID" value="ENSMZEP00005001809.1"/>
        <property type="gene ID" value="ENSMZEG00005001449.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471315"/>
    <dbReference type="KEGG" id="mze:101471315"/>
    <dbReference type="CTD" id="79065"/>
    <dbReference type="GeneTree" id="ENSGT00390000014839"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="17 28" id="KW-0072">Autophagy</keyword>
    <keyword evidence="23" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="19 28" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="21 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 28" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="718"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00045832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="855" mass="97096" checksum="F965BBE1C03439CB" modified="2019-02-13" version="1">MAHFDTEYQRLEASYSDSPPGEENLLMHVPEGVKSQWHHIENLDLFFQRVYNLHQKNGFTCMLLGEIFELVQLLFVVGFTVFLANCVDYDVLFANKFVNHTDSSKVTLPDAFLPVDVCSARIRNNAFVIFVLIISGVFWLHRLFKFIYNVCCYWEIRSFYINALKMTMSELPYATWQEVQARIVEIQKEHQICIHKKELTELDIYHRILRFKNYMVAMVNKSLLPVRFRLPVLGEYVFYTRGLKYNFELIFFWGPGSLFENEWSLKQEYKRGGNRLELADRLASRILWIGIANLLLCPVILVWQILYAFFSYTEVIKREPGSLGARCWSLYGRCYLRHFNELDHELMSRLSKGYKAASKYMNCFLSPLLTVVAKNVAFFAGSLLAVLIALTIYDEDVLAVEHVLSSITLLGVCITICRSFIPDKHMVFCPEQLLRVILAHIHYMPDHWQGNAHRYETRDQFSQLFQYKAVFILEELLSPVVTPIILIFCLRRKSLEIIDFFRNFTVEVVGVGDTCSFAQMDIRQHGHPAWMSEGKTEASIYQQAEDGKTELSLMHFAITNPQWQPPRETTHFISQLKERVHREATGAPSDTHPMSLSESEPRSLIANLLTGPSTLASVHFDRDISLANHAAAGINDGGSALRSLSPISSSLHLRGSLSAAHRAAGHTSRTMAGSGTDARTVSSGSSAWEGQLTSLVLSEYASTEMSIHALYMHELHKQQSRGEMSRHTWHRQESDESSDSIPDEVRSEPIPHSRNFPRSHTFPTTVPSPSAIPTSASATSSTALGQERPTAQSSSQRHHSGPTTDPFGTGVKIVRSARVPMGGWAEDGQTAQRHHEPLPEESLEDEMPPHIHKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWT6</accession>
    <name>A0A3P9AWT6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Prostaglandin E2 receptor EP2 subtype</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Prostanoid EP2 receptor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573327.1">
        <property type="nucleotide sequence ID" value="XM_004573270.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004573328.1">
        <property type="nucleotide sequence ID" value="XM_004573271.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWT6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002165"/>
    <dbReference type="Ensembl" id="ENSMZET00005002266.1">
        <property type="protein sequence ID" value="ENSMZEP00005002165.1"/>
        <property type="gene ID" value="ENSMZEG00005001734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463917"/>
    <dbReference type="KEGG" id="mze:101463917"/>
    <dbReference type="CTD" id="393608"/>
    <dbReference type="GeneTree" id="ENSGT01050000244902"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004957">
        <property type="term" value="F:prostaglandin E receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071380">
        <property type="term" value="P:cellular response to prostaglandin E stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15139">
        <property type="entry name" value="7tmA_PGE2_EP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000212">
        <property type="entry name" value="Prostaglandin E2 receptor EP2 subtype"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000370">
        <property type="entry name" value="Prostglndn_IP_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF8">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00856">
        <property type="entry name" value="PRSTNOIDIPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="41"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="373" mass="42324" checksum="B282B129DDA6C1B6" modified="2019-02-13" version="1">MGESNCSRIDVDNDTCHFKHHINPPVNPLISASMFAIGIFGNVAALVILEIRRRRNVRSGGTWQRSLFHILITSLVVTDLTGTCLVSPLVLLSYSRNLTLIGMRPKTCGLCSYFGASMTFFSLATMLLLFSTALERCFAIGYPYLYSRHVTKKCAYITILLVFLLCIIFCLLPFAGFGRYVQYCPGTWCFIDMNAVKPQNKAYAILYATFMLVLVVAIVVCNAFVVYQLYRMYQRRRRNGTVMSTMRSNSERKLLSMSEEVEHLTMMVVMTVIFIICTLPLVIRVYINYNGENDHPSDLIALRFISVNSIVDPWVFILLSPGVQHFCWTSVCQSTLIDQRGSVFKSSLAKENAKLELSRPTLYMEQIDSVKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXZ6</accession>
    <name>A0A3P9AXZ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXZ6"/>
    <dbReference type="Ensembl" id="ENSMZET00005002632.1">
        <property type="protein sequence ID" value="ENSMZEP00005002519.1"/>
        <property type="gene ID" value="ENSMZEG00005001993.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164468"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000001">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.60:FF:000007">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000129">
        <property type="entry name" value="protocadherin alpha-C2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF296">
        <property type="entry name" value="PROTOCADHERIN 1 GAMMA 11 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="128"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="237"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="341"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="446"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="570"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="772"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="796" mass="88026" checksum="70D542C4352A0F57" modified="2019-02-13" version="1">MKKLTMERQVLIISIFCLSYVVGQVSYSVPEEMAKGSLVGNIAQDLGLDVKRLRSGKARLYTGDSVQYIELNRERGVLLIKEKIDREVLCRQTTPCALHFQITLESPLELFPVTVEITDVNDNAPVFQKEERVFEISESAIVGSKFMLEKAIDPDIGLNGLQRYTLKPSDNFVLKLHAQSDGSKKVEMILQKPLDREKQEHISLVLTAEDGGEPQMTGTMKIYVTVLDANDNAPVFSKPVYKASITENSVKGTLVTKVTASDADKGTNGEVTYVIGNSMDTVSKLFHINNEGDVILDGLIDYEIEKNYNIDIEAIDQGGLSDSSKLIIDVIDVNDNRPVVNMISASGSIPEDSARKTVIALMSVNDPDSENNGKVNCVINENIPFEIKFTSNNFYSLVTDSDLDRERASNYNITVICTDEGVPSLSSSVTLTLQISDVNDNAPVFERSSYEAYIVENNTPSLSIFTVKATDADWNQNARVSYILEDSSVNGVPVSSYVSVSADSGVIHAVRSFDYEQIKDFHFRVKAQDGGSPPLSSNVTVKIMIQDQNDNPPQVLYPVQTGGSLVAEMVPRSADVGYLVTKVVAVDVDSGQNAWLSYKLQKATDRALFEVGLQNGEIRTIRQVTDKDAVKQRLTVIVEDNGQPSRSATVVVNVAVADSFPEVLSEFTELTHDKEYNDNLTFYLVLALAVVSFLFITCLLVIISVKIYRWRQSRILYHSNLPVIPYYPPRYSDTLGTGTLPHVYNYEVCRTTDSRKSDCKFGRAGSQNVLIMDPSSTGTMHSSPILKPQRQEAHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYD0</accession>
    <name>A0A3P9AYD0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC. When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP. Start codon recognition also induces a conformational change of the PIC to a closed state. This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with eIF1A (EIF1AX) during scanning. Interacts through its C-terminal domain (CTD) with EIF1 or with eIF2-beta (EIF2S2) (mutually exclusive) through a common binding site. Interacts through its C-terminal domain (CTD) with the CTD of EIF5B. Interacts with FMR1 isoform 6; this interaction occurs in a RNA-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014263079.1">
        <property type="nucleotide sequence ID" value="XM_014407593.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024661982.1">
        <property type="nucleotide sequence ID" value="XM_024806214.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024661983.1">
        <property type="nucleotide sequence ID" value="XM_024806215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYD0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002691"/>
    <dbReference type="Ensembl" id="ENSMZET00005002806.1">
        <property type="protein sequence ID" value="ENSMZEP00005002691.1"/>
        <property type="gene ID" value="ENSMZEG00005002102.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468208"/>
    <dbReference type="KEGG" id="mze:101468208"/>
    <dbReference type="CTD" id="1983"/>
    <dbReference type="GeneTree" id="ENSGT00390000016478"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000018">
        <property type="entry name" value="eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="W2" evidence="16">
        <location>
            <begin position="229"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="381"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="432" mass="49276" checksum="83D7F4D889C2946B" modified="2019-02-13" version="1">MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKFFGCELGAQTQFDTKNDRYIVNGSHEANKLQDMLDGFIRKFVLCAECDNPETDLHVNPKKQTIGTSCKACGYRGMLDTRHKLCTFILKNPPESNDSGSASVKKEKEKKNRKKDKENGSGSGEAGNHDNFDAPEAVDRDDDDEDWAEETTEEAQRRRMEEISDHAKNLTLSEDLEKPLEDRVNLFYSFVKNKKESGTIDAADKEILAEAERLDVKAMGPLILSELLFNENIRDQIKKYKRHFLRFCHNNKKAQKYLLGGFECVVKLHQVQLLPRVPIILKDLYDADLLEEDVIFAWAEKVSKKYVSKELAKEIHAKAAPFVKWLKEAEEESEGSEEEEEEDDENVEVVYSSSARELKVETVKPDTPEKEEDDIDIDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYG5</accession>
    <name>A0A3P9AYG5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 18">P2X purinoceptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">P2X purinoceptor 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Receptor for ATP that acts as a ligand-gated ion channel.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer and heterotrimer; functional P2XRs are organized as homomeric and heteromeric trimers. Homotrimer. Forms heterotrimer with P2RX1. Forms heterotrimer with P2RX6. Forms heterotrimer with P2RX3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 18">Belongs to the P2X receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012779015.1">
        <property type="nucleotide sequence ID" value="XM_012923561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYG5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002726"/>
    <dbReference type="Ensembl" id="ENSMZET00005002842.1">
        <property type="protein sequence ID" value="ENSMZEP00005002726.1"/>
        <property type="gene ID" value="ENSMZEG00005002040.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483332"/>
    <dbReference type="KEGG" id="mze:101483332"/>
    <dbReference type="CTD" id="387301"/>
    <dbReference type="GeneTree" id="ENSGT01020000230351"/>
    <dbReference type="OrthoDB" id="494673at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004931">
        <property type="term" value="F:extracellularly ATP-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001614">
        <property type="term" value="F:purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033198">
        <property type="term" value="P:response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.490.10:FF:000001">
        <property type="entry name" value="P2X purinoceptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.940">
        <property type="entry name" value="atp-gated p2x4 ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.490.10">
        <property type="entry name" value="atp-gated p2x4 ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003045">
        <property type="entry name" value="P2X2_purnocptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027309">
        <property type="entry name" value="P2X_extracellular_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001429">
        <property type="entry name" value="P2X_purnocptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059116">
        <property type="entry name" value="P2X_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053792">
        <property type="entry name" value="P2X_RECEPTOR_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00863">
        <property type="entry name" value="P2X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125">
        <property type="entry name" value="P2X PURINOCEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125:SF18">
        <property type="entry name" value="P2X PURINOCEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00864">
        <property type="entry name" value="P2X_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005713">
        <property type="entry name" value="P2X_purinoceptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01309">
        <property type="entry name" value="P2X2RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01307">
        <property type="entry name" value="P2XRECEPTOR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01212">
        <property type="entry name" value="P2X_RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 14 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="17">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005713-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005713-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005713-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="396" mass="44521" checksum="5DDDD91493D5FA99" modified="2019-02-13" version="1">MSKSAGCCKRFLHYAFDYETPKTLVIPSLGVGFVFRFTQFLVVMYVVGYVCVVQKAYQDTDTVISTVTTKVKGFAFTNTSDTEPRFWDVADYIIPPQSDHSFFVLTNMVVTPKQVQSHCPELPSPSTTCVDDCNCVEGRSDPRGNGIQTGLCENYSTTARTCEVLSWCPLEIDTKLPEHALLVAAENFTVLIKNSITYPKFNFHRRNILPHVNSSYLKRCEFSRLTDPHCPIFRLKHIVSEAGEDFQDMAVKGGVLGILIDWSCDLDWWAGECLPKYSFRRLDNKHPVNNVAPGYNFRFAKYYKAADGEETRTLIKAYGIRFDVIVFGTAGRFSIVPTIVNLGAALSFLSLVPVVADWFLVTCSRKRDLYSRHKTTHLTEDADSASVSMGTTYGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B013</accession>
    <name>A0A3P9B013_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="22">RAD50 double strand break repair protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 24">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550391.1">
        <property type="nucleotide sequence ID" value="XM_004550334.2"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005003251"/>
    <dbReference type="Ensembl" id="ENSMZET00005003381.1">
        <property type="protein sequence ID" value="ENSMZEP00005003251.1"/>
        <property type="gene ID" value="ENSMZEG00005002481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477643"/>
    <dbReference type="KEGG" id="mze:101477643"/>
    <dbReference type="CTD" id="10111"/>
    <dbReference type="GeneTree" id="ENSGT00390000018781"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000947">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001037">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.510:FF:000001">
        <property type="entry name" value="RAD50 homolog, double strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75712">
        <property type="entry name" value="Rad50 coiled-coil Zn hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="21">
        <location>
            <begin position="635"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="203"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="415"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="587"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="712"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="846"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1043"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1312" mass="153224" checksum="6F5F35F009A646F2" modified="2019-02-13" version="1">MSKIDKMSILGVRSFGIEDKDKQVISFFTPLTVLVGPNGAGKTTIIECLKYATSGELPPGSKGGAFVHDPKDAHETDVRAQIRLLFSDVNGEKVTIQRSMSCTQKAKSYTFKSLEQVITRWKDGEKVSLSSKCGELDREMISALGVSKPVLNHVIFCHQEESNWPLSEGKALKDKFDSIFAATKYIKALETMRQLRLKQSQTVKECQVELRYLKQNKEKAQQIRETVDTKEAQLMASKASVQQIENQIEPLENRLMDIDLKLGKVMKLDNEIKALDSRKKQMEEDNKELEETMEQVFQGSDEELQDIYQNHQGTVREKERRLTECQKELERAGRECQRLNRIKAELLGEQGRLQSEADHHTQNIRKRDTQVRSLSTYLEMEGYDRPPFTALQLESFHRHVTQRLEQEKGTLGQVMVDLQEKEQQKQQSIDEMRDKKTGLERTVELKRDMQGKKQQELRSVRAELQRLEGSSTRLQDLENELAKVERELQSAIQNSNVEELKAEVSELQREKAELDRKQRRLDQEMETLNTHMTARTEMDMLKKNKGEKEEQVRKFKSRHSEDLVSLLGHFPNKRELEDWIYSKSKEINSTRNRLAKLNKDLASSEQNKSHISAELRKKEQQLTSDEEKFFNVCGSQDLDQDLGKLQEDLEKISKQRAMLAGATAVYTQFISQLTEDREPCCPVCQRTFPSESDLQEVINDMQSKLRLVPDKLKNTEQDLKRKERKKDEMMALKPVRQSIVQLQEKELPELKNRLQTVNREIERLKGDVEEQETLLGTLMSEEETAKACLQDISLMDRYLMDLKDVERKIAQHAAKLQGVDLTRTTQQVSQEKQETQHKLDTTSSKMELKRKLIQDQQEQIQMLRSAVNETRAEKLQLSSDMQKQQQLEEQCAEFTTEIQSLTRDIREAKEQLSPLSATLEKLQQEKQELLERKRQKQEEGQEKISSIKEKLKAITTLEKDITKYVDEGKDEYKEQKESELHETNTQLHEAEKHKEKINKEMGNIRQDIDTQKVQERWLQDNLTLRKRVEELKEVLGKREALMKDMGNMQVMQLRKERREAERKLEDLKRNRSIALGRQNGFEEEILHYRKELREDQYDKADERYRNKMITMRTTELVIKDLDLYYKALDQTIMKFHSMKMDEINKIIRDLWRSTYRGQDIEYVEIRSDVDENSSAGVRRRVYNYRVVMVKGDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSRQRNFQLLIITHDEDFVELLGRSSYIEHFYRIRKNQDQNSEITKCSINSLSSYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B196</accession>
    <name>A0A3P9B196_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)H dehydrogenase, quinone 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B196"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003492"/>
    <dbReference type="Ensembl" id="ENSMZET00005003624.1">
        <property type="protein sequence ID" value="ENSMZEP00005003492.1"/>
        <property type="gene ID" value="ENSMZEG00005002686.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159150"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000054">
        <property type="entry name" value="NAD(P)H dehydrogenase, quinone 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF34">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE [QUINONE] 1 ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like fold" evidence="3">
        <location>
            <begin position="3"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="251" mass="27673" checksum="FB3B8BBE91BDF74B" modified="2019-02-13" version="1">AAAKDAAVAALTAQGCTVDVSDLYAMKFKAAATTEDITGGVKDAESFCYAKEIKLASEEGKLAEDIKKEQEKLKEADLVIFQFPMYWSSVPAIMKGWMDRVLGFAYAQEKRYSEGIFKDKKAMLSFTTDCPESVYSDTGINGDINVTLWPLQNGILNYCGFQVFAPQIFWDPATGSPESHSSMLEGWRTRLQNLCGEATVYFAPMDYFDKEKGFLLKPEVKEKYASKESGLTVGIHMGKPLPANSQTKAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1T7</accession>
    <name>A0A3P9B1T7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 16 member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC16A3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B1T7"/>
    <dbReference type="Ensembl" id="ENSMZET00005004025.1">
        <property type="protein sequence ID" value="ENSMZEP00005003866.1"/>
        <property type="gene ID" value="ENSMZEG00005002987.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158181"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015650">
        <property type="term" value="F:lactate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17430">
        <property type="entry name" value="MFS_MCT3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000077">
        <property type="entry name" value="Proton-coupled monocarboxylate transporter 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004743">
        <property type="entry name" value="MCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00892">
        <property type="entry name" value="2A0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF27">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="487" mass="52004" checksum="9B30612179526192" modified="2019-02-13" version="1">MGGAVLDDGPPGVKAPDGGWGWAVLAGCFVITGFSYAFPKAVSIFFKDLIQEFEVGYSATAWISSILLAMLYGTGPLCSVLVNRFGCRPVMMVGGVFASVGMILASFAKSITHIYLCTGVITGLGLAMNFQPSLIMLNCYFSEKRPLANGLAAAGSPVALCCLSPLGQSLQNQYGWRGGFLILGGMLFNCCACGALMRPLSTPKKSQMLEENTLLAADKPKAKKKLLDFSVFKDRGFVIYAIAASVMVLGLFVPPVFVVSYAKGLGYKDTNSALLLSILGFVDMFARPASGLIAGMKRVRPRSVYLFSFAMIFNGCTDIIGSQAKNYAGLVVFCIFFGISYGMVGALQFEVLMAIVGKEKFSSAIGLVLLMEAVAVLVGPPGAGQSRLLDATHQYMYVFLLAGCEVTVSAFVIATGNFLCIRREREDGQAKIEMAVSAAELEGLNQAANEEHDGGKKEQTGKENGKVRVLKVQEDMTVTEAPEDTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2X8</accession>
    <name>A0A3P9B2X8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytokine-like nuclear factor N-PAC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glyoxylate reductase 1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nuclear protein NP60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Putative oxidoreductase GLYR1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574698.1">
        <property type="nucleotide sequence ID" value="XM_004574641.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2X8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004268"/>
    <dbReference type="Ensembl" id="ENSMZET00005004448.1">
        <property type="protein sequence ID" value="ENSMZEP00005004268.1"/>
        <property type="gene ID" value="ENSMZEG00005003309.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470017"/>
    <dbReference type="KEGG" id="mze:101470017"/>
    <dbReference type="CTD" id="84656"/>
    <dbReference type="GeneTree" id="ENSGT00940000156435"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05836">
        <property type="entry name" value="PWWP_GLYR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000058">
        <property type="entry name" value="Putative oxidoreductase GLYR1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000011">
        <property type="entry name" value="putative oxidoreductase GLYR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000027">
        <property type="entry name" value="putative oxidoreductase GLYR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035501">
        <property type="entry name" value="GLYR1_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="11">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="507" mass="55379" checksum="D14BBA384C4EC039" modified="2019-02-13" version="1">MATVHLRIGDLVWGKLGRYPPWPGKIVSPPKDLKKPRGKKCHFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEDFLKKAKGKEQNSDGKGDSKGKKTPNKPLKILDEDDEDLSALKDPSEKDLADSDPEPSTIERLGAGPGSGFKWESSPVKDDPHFHHFLLSQSEKPASSMEPISKRLKIIEEVTGSTSIQAADSTAINGSITPTDKRIGFLGLGLMGSGIVSNLLKMGHVVTVWNRTAEKCDLFIQEGARLGRTPAEVASMCDITFSCVSDPKAARDLVLGPSGVLQGIRPGKCYVEMSTVDPETITELSQVITSRGGRFLEAPVAGSQQLSNDGMLVILAAGDRTVYEDCSSCFQAMGKTSFFLGEAGNAARMMLILNMVQGSFMATIAEGLTLAQATGQSQQTFLDILCQGQMASTFVDQKCQNILQGNFKPDYYLKHIQKDLRLAISMGDMANHPTPMAAAANEVYKRAKALDQSDNDISAVYRAYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B465</accession>
    <name>A0A3P9B465_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G protein-coupled receptor 176</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004550598.1">
        <property type="nucleotide sequence ID" value="XM_004550541.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B465"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004671"/>
    <dbReference type="Ensembl" id="ENSMZET00005004875.1">
        <property type="protein sequence ID" value="ENSMZEP00005004671.1"/>
        <property type="gene ID" value="ENSMZEG00005003612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484497"/>
    <dbReference type="KEGG" id="mze:101484497"/>
    <dbReference type="CTD" id="11245"/>
    <dbReference type="GeneTree" id="ENSGT00950000182998"/>
    <dbReference type="OrthoDB" id="9339792at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="78"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="574" mass="62590" checksum="ABE3545B5CAA0CE7" modified="2019-02-13" version="1">MDSAGSRAAMVGDGAVNFTAAHLWLDLLNASSPSTRWDSSPPAEGTGLDERQRLVREQAYRDFTTTVQVFILLGSLIGNATVLWCTCCTNVFKTVTNRFIKNLAWSGICAGLVCIPFDVALGANPRCCLWLHTLVLCKALKFLHKLFCSVTVLSFSAIALDRYYSVLYPLERKISDARSRDLVIYIWVHATVVSLPVFAVTNVTDVYVTSSCSNDPARSLSHMVYVLIYNITTVILPLALVFLLMLLIRRALSASQKKKVIIAALRTPQNSISIPYVSQREAELHVTLLAVVLAFSACSAPYGALVFYRTILADAKELPVSLYLTALWLPKVSLLTNPLLFLTVNRSARHSCLDLLARIHRRYSRRNVVSTGGLASLGADGVIGEPVGLETAGRSGSQLLEMFNIGQQQIFRPSEEEEEEDGENDVELPSQGSGEGSGPKDDQKGGSRMGSLRGEVINKKDSLQGTGGGLVITKEVPPSVIAPRASPVHTCAYASSSQVAPATPTEAEDSPQFGFGPFELPPQWLPETRNSKKRLLPPLGNTPEELIQTKVPKQKPERRISRNNKVSTIPTVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B510</accession>
    <name>A0A3P9B510_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat and sterile alpha motif domain containing 4B</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004558364.1">
        <property type="nucleotide sequence ID" value="XM_004558307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B510"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004862"/>
    <dbReference type="Ensembl" id="ENSMZET00005005074.1">
        <property type="protein sequence ID" value="ENSMZEP00005004862.1"/>
        <property type="gene ID" value="ENSMZEG00005003779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484264"/>
    <dbReference type="KEGG" id="mze:101484264"/>
    <dbReference type="CTD" id="257629"/>
    <dbReference type="GeneTree" id="ENSGT00390000017548"/>
    <dbReference type="OrthoDB" id="76949at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000034">
        <property type="entry name" value="ankyrin repeat and SAM domain-containing protein 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000074">
        <property type="entry name" value="Usher syndrome type-1G protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="345"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="421" mass="46338" checksum="B2DD54F4B51A2048" modified="2019-02-13" version="1">MSRYHKAAIDGYVELLKEATVKDLNTPDEDGMTPTILAAFHGHISALQLICSRKGDPNRSDIWGNTPLHHAAGNGHMHILSFLVNFGANLFALDNEFHTPMDVAASRDHMECVRFLDAAAAKQTNQNPKKVANLKKEAEKEAEKRVKLCEKVKKKHKSKMDRMQRGSNSGSFSDAGTASSLSNDGTITGVNEHFSKLITDDKVGSIKGTLLKKFGKKDKGTLQRSEGSGNVIFLKPESGSENPDFVDVFNEQEENMLEEMDSFGDDDDDGGQVKQSIFNRPGLGGLMFRKKMGLDSDDIPSSANESLGYLVQSETFEADEDTSGLMTGDNALPWEQEDLGLDDDEDEETSPLDVFLSSISLPDFTPAFNREHLDLEALLLCSDEDLKGIRIQLGPRKKILEAVARRRKALENAGVMKDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B569</accession>
    <name>A0A3P9B569_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Paired amphipathic helix protein Sin3b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Histone deacetylase complex subunit Sin3b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcriptional corepressor Sin3b</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the SIN3B complex, which includes SIN3B, HDAC2 or HDAC1, PHF12 and MORF4L1. Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with C6orf89. Interacts with MYT1L.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004555099.4"/>
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        <property type="protein sequence ID" value="ENSMZEP00005004927.1"/>
        <property type="gene ID" value="ENSMZEG00005003816.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101466159"/>
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        <property type="component" value="LG23"/>
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        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:transcription corepressor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ossification involved in bone maturation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:swimming behavior"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
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        <property type="entry name" value="SIN3 transcription regulator family member B"/>
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        <property type="entry name" value="Paired amphipathic helix"/>
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        <property type="entry name" value="HDAC_interact_dom"/>
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        <property type="entry name" value="PAH_sf"/>
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        <property type="entry name" value="Sin3-like"/>
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        <property type="entry name" value="Sin3_C"/>
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        <property type="entry name" value="PAIRED AMPHIPATHIC HELIX PROTEIN SIN3B"/>
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    </dbReference>
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        <property type="entry name" value="SIN3B-RELATED"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="16">
        <location>
            <begin position="452"/>
            <end position="552"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="126"/>
            <end position="210"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
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            <end position="326"/>
        </location>
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            <begin position="660"/>
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            <begin position="742"/>
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        </location>
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            <begin position="133"/>
            <end position="156"/>
        </location>
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            <begin position="167"/>
            <end position="210"/>
        </location>
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        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
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        <location>
            <begin position="761"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
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            <begin position="819"/>
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        </location>
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        <location>
            <begin position="840"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="859"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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    <sequence length="1268" mass="143484" checksum="A94850105A9F2932" modified="2019-02-13" version="1">MAKIQAHSTAKQINQIQDKPYVITQKQVQQQHFQKLKVEDALSYLDQVKIRFANDPGIYNKFLDIMKEFKSQSIDTPGVINRVSQLFHGHPDLVLGFNAFLPPGYRIEVPKNGMAFLQSPFSAQVSPSPQGKSPVAPAVAATSGSASSSHSEVGPAQTSEVKVATTEPLSSSAAGPPEPPSRLSLPLTSRESQNPAATSSVSPPASETSPVEFDSAISYVNKIKNRFLDHPEIYRAFLEILHTYQKEQLEVKESRGSRGSSGMTEDEVFSKVASLFKGQEDLLAEFGQFLPDAKRSLFTGSSLTGGKEQLKRTEEEDTITKQNKKRPRPILLQHMSPLLKKKMKYSCTKDQSFASVGKHGVLREFSFFDKVRRLFKSQEVYENFLRCIALFNQEVVSGAELLQLVTPFLGKFPELYTQFKSFLGDKELSHAVSGLSDRYMEGGGGREVDYASCKRLGSSYRALPKTYQQPKCSGRTALCKEVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRLSPEDQDRFRLDDCLGGTSEVIQRRAVYRIYGDKAPEIIEGLKRSPATAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQGVNFKQNDMKALRSKSLLNEIESIYDERQEQSTEEGGVGQQSRNGSASSSEPHMVFTYEDKQILEDAASLIIYHVKRQPTIHKDDKDHIKRIIQHFVPDLFFSRRGELSDTEEWTDEEAELEEGGDKGGGGTATTAAGGGGNGNNASGAAASSCQSQPQPVQSQSQTQSQPQQQLNGDSRRRRCSPSQPAENEASTTSSSISQPAGSTPTPGSTPMEMSSGAAGEKVDLRDPEAEHQKELDGVYNLFFVNNNWYFFLRLHQTLCSRLLRVYRQAERQLLEHRAEQSRERLLMAEGRREKACDLAMELRLKQPSEVELEEYYPAFLDMVRSLLDGNLDSTQYEDTLREMFTIHAYIGFTIDKVIHNIIRQLQHLVSDEVCLQVVELYLAERKRGAAGGNLSSQCVRAAWETSYQWKAERVMAEENCFKVMFIQNKGQVTMTIELLDTEEAQADDPLDVQCLSSYMEQFVGTESSLCSQAEGYFFKPVFLPRNLRRFRRWQVRQVEAMRCRREWHRQLGVENAGSLDCRFKLNTHKMVFVMNSEDYMYRRGALVKARKSQHRVAASQHERFDKWHQSWLTNHVTASAERSVQNWLMGEDEEDLIPCKTTCLSTEVKGQMVNRYQVHYSGSKAPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6B4</accession>
    <name>A0A3P9B6B4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cathepsin L.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
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        <property type="gene ID" value="ENSMZEG00005004123.1"/>
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        <property type="component" value="LG19"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cathepsin S"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018778683" evidence="7">
        <location>
            <begin position="17"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="118"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="356" mass="39675" checksum="6A184CF52C2C3976" modified="2019-02-13" version="1">MKLLLVVAAVLAVSSCASISLEDLEFHAWKLKFEKSYDSESEEAHRKQIWLNNRKHVLVHNILADQGLKSYRLGMTHFADMENEEYRRLVSRGCFGSFNTSLHHRGSTFLRLPEGTDLPDTVDWRDKGYVTDVQNQMQCGSCWAFSAIGALEGQNFRKTGKLVSLSKQQLVDCSQSFGNHGCNGGWMDYAFKYIQATGGIDTEESYPYEAEEGNCHYNPETVGATCTGYVDVSPNEDALKEAVATIGPISIAVDASHESFQFYQSGVYDEPSCITSRYSHAMLAVGYGTENGHDYWLVKNSFGLGWGEKGYIKMSRNKSNQCGIASKASYPLHKLQFVVCTPCSSAAHTIQFYTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BA91</accession>
    <name>A0A3P9BA91_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cadherin-22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pituitary and brain cadherin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Cell membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004547696.1">
        <property type="nucleotide sequence ID" value="XM_004547639.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BA91"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006823"/>
    <dbReference type="Ensembl" id="ENSMZET00005007125.1">
        <property type="protein sequence ID" value="ENSMZEP00005006823.1"/>
        <property type="gene ID" value="ENSMZEG00005005232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484764"/>
    <dbReference type="KEGG" id="mze:101484764"/>
    <dbReference type="CTD" id="64405"/>
    <dbReference type="GeneTree" id="ENSGT00940000159376"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000007">
        <property type="entry name" value="Cadherin 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000008">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000009">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000012">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000017">
        <property type="entry name" value="Cadherin 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000014">
        <property type="entry name" value="Cadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF311">
        <property type="entry name" value="CADHERIN-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017954073" description="Cadherin-22" evidence="18">
        <location>
            <begin position="30"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="81"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="162"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="271"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="385"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="19">
        <location>
            <begin position="489"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="805" mass="88267" checksum="EF80040BB79357E1" modified="2019-02-13" version="1">MAPSWTSGVWTLLAALTLLSCNIFTWCEASRTSGTTTSGERDQEQGPSSLERVKRGWVWNQFFVVEEYTGTEPLYVGKIHTDSDDGEGNIKYTISGEGAGSIFIIDELTGDIHATERLDREEKAFYTLRAQARDRLSNDPLEPESEFVIKVQDINDSEPKFLEGPYIGSVAELSPIGTSVMKVTASDADDPTYGSSARVVYSVLDGEKFFTVDKNKGIIMTAVADLDRETQDRYELVVKATDMAGQMGGLSGSTTVTIVITDVNDNPPRFPQKMYQFSVSEGAAVGTPVGRVIATDADMGENTDMSYLITDGGELFKVTTDMETQEAVVSIKKPLDFENKRTHNVVVEAVNKHVDPRFVDLGSFRDQTIVLVSVSDTDEPPIFYPADGTIMEVQEDAKVGALVGIVTARDPDVKNKPVRFSIDRTTDQEMIFHIDPDSGAITLGKILDRETAGWHNITVKAVEADNHTMASQTSVSIRILDVNDNPPELATPYEASICEDAKPGQLIHTISVVDRDEPQSGHRFYFNLAPEASSNRYFSLLDLKDNTAGIRTQRSGFNRHEQNVYFLPILVVDSGPPSLSSTGTLTIRVCGCDTDGAIQSCNATAYVMSAALSPGALIALLVCMLILIVLVLLILTLKRHRKGQRMTEDEEDMRDNVIKYNDEGGGEQDTQAYDMSALRNLYDFPEAKSCDSGPDIRSLPQWIQAKRVGGSGAEAAAAAATDFSLFKGYIRKKVEQADADLSVPPYDSFQTYAFEGTSSPALSLSSIHTLSTTSEQDFSYLSEWGPRFRQLAGYYAPGNPEEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BB74</accession>
    <name>A0A3P9BB74_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized LOC101472033</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004548114.2">
        <property type="nucleotide sequence ID" value="XM_004548057.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BB74"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007149"/>
    <dbReference type="Ensembl" id="ENSMZET00005007459.1">
        <property type="protein sequence ID" value="ENSMZEP00005007149.1"/>
        <property type="gene ID" value="ENSMZEG00005005503.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000170761"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="735" mass="85021" checksum="3C1A8338E80105C6" modified="2019-02-13" version="1">MMDNFETPYEEEDIAFIECEICEKSLRGDTLYKIHLTTPGHIKKESGLVTSGRSVRRHVPEFKDIIEYLDYLNLDEPIIGLNFLEEGPPSDRQIGPKYLCKLCNQSAVLAEMVCHVIGRKHRQKYVELKRPDLVTWDRPSVQTLGGKIMRAKAEIIERQDGRGTPKSLFKKGNESRSNSSRASQRPRQNREQTNPQDLPPLLPELKDYHRRKHASSYPNASAFPPNDPNMNVDRRSQRENRLSNERTRDEPRRSDFREGHAYREGYMDSDYRHQYEEGYGGDSQRCLALEQGDAPKYDFREELPGGLGQSDYYPEGAPPYRRAYPERESVQDFHSEDVRGGNGRSEYSPSQAMYPEVDKLRWSLEREADRHDGMNKAGRQGSSEPEARRRNFSASMEGDRSRDNLFNIIQDYRHEMREVHQDEGVDRRAGGPASQRHMDVGRAISNIPEPFRRFLKGGAEDDVHGKRKRKSRFSDATPEEVEGTREMYGDNYGSPIPKFGGDPRPGSAPMSGGQFSDIYREPQGPHHPEMNQRGGSESEGVFDMLSNIEIENAEEADFLKSKLCNLLKEFKTKKMEKAVQNSHGREGIPRNYSNMELDPRQPPFERTMRDDSHHRQPEDLDFRDWRQREHLPEERHNVYPPPAHEDSRYSKRGRFEEESGTPHTNRLDEPPFYPERFPESLPSRDYQPPVGEFFDSHSSAPPLHMDQESRMPRGPRYSNNLDKITSALLELVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBL7</accession>
    <name>A0A3P9BBL7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase D family, member 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563218.2">
        <property type="nucleotide sequence ID" value="XM_004563161.5"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_004563162.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004563220.2">
        <property type="nucleotide sequence ID" value="XM_004563163.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBL7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007289"/>
    <dbReference type="Ensembl" id="ENSMZET00005007599.1">
        <property type="protein sequence ID" value="ENSMZEP00005007289.1"/>
        <property type="gene ID" value="ENSMZEG00005005611.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101487786"/>
    <dbReference type="CTD" id="558442"/>
    <dbReference type="GeneTree" id="ENSGT00950000183059"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF26">
        <property type="entry name" value="PHOSPHOLIPASE D FAMILY, MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="844" mass="93202" checksum="20B5D150BF08C3BA" modified="2019-02-13" version="1">MPMVLRSRKSLRPGEVQLPTSTPTARRSSRSRQERATYEESDESDSELVLLQEEMERREAELEEEAAEEADLTDLKDCSVVLDRLQADEKSLKKDLEEKEDMNRKGGKPVSRIPTFQKRPAGASQSTELPVPRKDTPVHAQPPEKLGSLETSKSKPPDPRETALPAPLFHTPKIGFEAPSTFSRTEVALATAHGPLIAAQPVHSPLLTASPRPALRSEQVKSKTSETTPDGPTTHLPRESFPSKIPWEEPAETYDPAVKDRILLTPSGDSEKSAEIFQAPEDSQVEAIMDEEPPWETEPLNTAGLRDSISSSEAECEDELAGERSEEVKEDRKLLISQSKFPKLEEKKADPDSDAAAAPKTPAKVKATKSAKRSGCPSFTLFCFLSTTLLLLGGFSHHVWHYGLPMSVSQLTAQLELHWLEGFGLLPEPCSTDCRVHLVESIPVGLYQSSPSSRKSIADSWLHLLDRANSSVHIAAFYFTLRDSDLGSHESSDSQGRKVFEQLMKLESKGVKLQIAVNAPQQSNHDTADLAGTGAEVREVDLKAVTGGIVHTKLWVVDQKHFYVGSANMDWRSLSQVKEVGLSVEDCSCLAQDAFRIFGVYWSIGGVINGSLPPYWPARLSALSSSQKPLHLKFNGVPAQVYLSSAPPQISARGRSDDLSTILSVINDAQGFVYISVMDFLPLSQFTEPLRFWPTIDTALRAAACTRGVRVQLLVSCWEHSSPDMFIFLQSLQVLRRHPLTCDIDVKIFTVPSTAEQKKIPFARVNHAKYMVTDRVVYIGTSNWSENYFAFTAGVGLVVNQTGSAVKPGQQTLQSQAEELFLRDWGSEYASTLPVEDVDVCPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCG7</accession>
    <name>A0A3P9BCG7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Microtubule associated serine/threonine kinase family member 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005007583"/>
    <dbReference type="Ensembl" id="ENSMZET00005007899.1">
        <property type="protein sequence ID" value="ENSMZEP00005007583.1"/>
        <property type="gene ID" value="ENSMZEG00005005800.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156399"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051067">
        <property type="entry name" value="NHER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191:SF27">
        <property type="entry name" value="MICROTUBULE ASSOCIATED SERINE_THREONINE KINASE FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14191">
        <property type="entry name" value="PDZ DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
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            <begin position="141"/>
            <end position="212"/>
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    </feature>
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            <dbReference type="Ensembl" id="ENSMZEP00005007583.1"/>
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            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="1809" mass="194960" checksum="0BDC90CD311DAC2D" modified="2019-02-13" version="1">MGHIKLTDFGLSKVGLMNMTTNLYEGHIEKDAREFSDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPDGDEAPPPDAQELITLLLRQNPLERLGTGGAAEVKQHQFFHNLDWNGLLRQKAEFIPQLESEDDTSYFDTRSERYHHLETEEEDTNDEDFNVDLRQFSSCSHRFSKVYSSLDLSRGHLEEKGETEEKKTESPLTVDSLSWTPDFAEAPSLSSTDTDSMNQGPRPSLLPKFAISAESEGDETSGIGDPSKASFSIGEFPQDEPEAATPGSTHSGATLSGSFSEHLDQLTPRGEGVESPDSTSHTSADHGPPSTSLRPESAVEKSGAVPKVPKSVSTGALSLMIPGDIFGASPLASPLSPYSLSSDPSSRDSSPSRDSSLCPSNPRQPVMIHSSGKKFGFTLRAIRVYACDSDIYTVYHMVWNVEDGGPAHKAGLKAGDLITHVNGEPVHGLVHTEVVELLLKSGSKVAISTTPFENTSIKTGPARRNSYRSKMVRCGKKPKKEKTPERRRSLFRRFAMQPSPLLHTSRSFSSLNHSLSSGESLPGSPTHSLSPRSPTAAFRPAPDFTQSGGNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLGPKLPGQRLRQGRRKSAGSIPLSPLARTPSPTPQPTSPQRSPPPLLSGHSVAISKTTQGFPAKIHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSYTGEKKHLCPRKRSLEVTQEEVQDEDVRTGERDFTGLQSVDEAACEPLTITRLRPVEQGCLKRPISRKMGRQESIEELDKEKLKSKMVVKRQEWSERRESLQKQDALHESDSSAPCAYDGDEGFLVRSQNKVQSSPESGTLEAKAASSTLKDVLYKKLSTRVSEGIAEPSGGSSESDGALRSALCSGHPEWQHSRQGKDGMKPDRLDFKAPSIEFTRKRLSFEEREDCMCRLTSTLHENLHFGSTRSKSLQLDTAMPHDHMKAGLGSVHSSPEGLAPKLFSGRGESAVEKLHLISSAESPLRKTSSEYKLEGRHVSSLKPLEGTLDIGLLSGPRVSKTETCLSKMAENTSDTVSVNPPIRLQSPTERQITIPQTKTTDKMKSPLTCSLSPEAVSSVNSIVVSKEQSNNSATEMKVNASGEKTQDRQGESLKASNSKADPSTFSVKQEGRTGMKASHEHRGPRHSSHFSSCGKTPSIREVSNEDQEDEVEQQEEIPDTTSQNTDSSKTAVSLVDLKTSPPFTTLEARAVSKPLTGPLKQSADSVLDTGQLQSCEKRKTAAQSSDTTSRPASEANVQTNSASVHVPANVPNICSSNTEPGVSVSASAFGALPDSKSEHSETSVSSSVKLVGDAGSSGSKTENSASSTAAKVEQKKEVCTINKATSLNIITDATLNKKHNTVSAAAVQDSGMSLQKKDVNVSPKTKNTAAVKDSEQPSQMCPTEKAQHRSSDAQLCTSVVSVKENTVVPSAKLKSSGATATSETVSSPKSKSRPDPQPTLPTSVKREKEAKTQESAAPPVPAVKGSPSSKEKDLPKESAPSTSHVQATHDAKRKEASPVSASDGAKSEDSVQAKPLPTHADTRQREIQPKCSAAVKDVPNSKLKSLPPKTSSALKPAAAPAIKQTLDSKPKDTSPKNHPTVIKDPRDPKTKECALPLTTSQQLRKEPLPPSDVSSQPDPPAVLPKLPAKTEPPSSADTSGKGFSCEPAVKISKDAPKSDTRTTTPDKPASSLRKEQGERKKKETAQEVTPAQKNTKRDTSRASPSAAKDSLDRDTSRCKQLKESPRSSSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEK7</accession>
    <name>A0A3P9BEK7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GTPase IMAP family member 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Immune-associated nucleotide-binding protein 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEK7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008327"/>
    <dbReference type="Ensembl" id="ENSMZET00005008660.1">
        <property type="protein sequence ID" value="ENSMZEP00005008327.1"/>
        <property type="gene ID" value="ENSMZEG00005006351.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271858"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000536">
        <property type="entry name" value="GTPase IMAP family member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF190">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="17">
        <location>
            <begin position="10"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="299" mass="34466" checksum="F30189666C7E8158" modified="2019-02-13" version="1">PQHMPNSSHEHPLRIMLLGKCGVGKSSSGNTILNKMVFCSEMKLASITVHCEKESAVVGDVPVDVIDTPGLFEKGSNKEDIIREILQRLKLQEPGPHVFAYVIPLGRLTQEDQDTHTLIEAKFGPRVWDYTIVLFTHGDRLEDKTINSIITESDENLRNFIRKCSGGFHVFNNKTPEDQKQVTTFMEKIETLVALNGGSYYKTELYPEKERKIRKRQESILAERDEEISKKEGNLREHYKDEELKKMKTKLWRKEEERARKDAERELYSMSYLMKIILLLAVLCLLLCCNLGVSLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGX1</accession>
    <name>A0A3P9BGX1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="5">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs. May regulate the activity of some transporters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with RSC1A1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004551029.1">
        <property type="nucleotide sequence ID" value="XM_004550972.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGX1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009143"/>
    <dbReference type="Ensembl" id="ENSMZET00005009492.1">
        <property type="protein sequence ID" value="ENSMZEP00005009143.1"/>
        <property type="gene ID" value="ENSMZEG00005006948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475338"/>
    <dbReference type="KEGG" id="mze:101475338"/>
    <dbReference type="CTD" id="79693"/>
    <dbReference type="GeneTree" id="ENSGT00390000015364"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000007">
        <property type="entry name" value="YrdC N6-threonylcarbamoyltransferase domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="60"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="267" mass="28887" checksum="5B6EB8748AFEF537" modified="2019-02-13" version="1">MKLVCSIAAVLVNTSKGVHGSVAARRISAEMFKELKTKVLRLLPPTSNGPTVHRDETDGAEILSCTVKALKEGHIVAVPTDTIYGLACLAQNSDAVRKTYDTKGRNGQKPLAICVGEIQDIYKYCKVKVKKELLGDLLPGPVTLVFERSEELNTDLNPFTSLVGVRIPDHPFMRQLCQMCGEPLALTSANISSHTSTVEVHEFQELWPKLAVVVDGGPIGDQSRLGSTVVDLSVLGKYSIIRPGCALSSTVDVLERKYGLSELSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJV6</accession>
    <name>A0A3P9BJV6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C1GALT1-specific chaperone 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545808.1">
        <property type="nucleotide sequence ID" value="XM_004545751.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJV6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010239"/>
    <dbReference type="Ensembl" id="ENSMZET00005010609.1">
        <property type="protein sequence ID" value="ENSMZEP00005010239.1"/>
        <property type="gene ID" value="ENSMZEG00005007726.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481901"/>
    <dbReference type="KEGG" id="mze:101481901"/>
    <dbReference type="CTD" id="29071"/>
    <dbReference type="GeneTree" id="ENSGT00940000155145"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000016">
        <property type="entry name" value="C1GALT1-specific chaperone 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF2">
        <property type="entry name" value="C1GALT1-SPECIFIC CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="317" mass="36256" checksum="335FF35169388CAB" modified="2019-02-13" version="1">MLSDGCSFMKGMLLGGVFCLVLSFLGSFNFSSESSTEDHHHHHIYAPSKDELKRLSDSRVEELKNQVRVYCIIMVQPKTLVYWATVLDTWSKHCDNAVFYTSEGSKALEAVDLNEKDDWARLRKALIHAYENAGDLRWFFVAQPTTFAIIENLKYLILAKDPNEPFYLGNAVKSGELEYVEYSSGIVLSYEALKRLMTMFKDEGQCPERTHTLWKMGEDKQLALCLKYAGVFAENGEDRHGKGLFNKQNVVNMIKQSMQDNPTDVVEGCCPDMAVTYGGMSPNQMHVMMFGVYRLRPYGHDFHDWLTFYPPKDSDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJV9</accession>
    <name>A0A3P9BJV9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Probable ribonuclease ZC3H12C</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573649.1">
        <property type="nucleotide sequence ID" value="XM_004573592.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004573650.1">
        <property type="nucleotide sequence ID" value="XM_004573593.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004573651.1">
        <property type="nucleotide sequence ID" value="XM_004573594.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJV9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010215"/>
    <dbReference type="Ensembl" id="ENSMZET00005010584.1">
        <property type="protein sequence ID" value="ENSMZEP00005010215.1"/>
        <property type="gene ID" value="ENSMZEG00005007718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478303"/>
    <dbReference type="KEGG" id="mze:101478303"/>
    <dbReference type="GeneTree" id="ENSGT00940000155107"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rege-1_UBA-like"/>
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        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
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        <property type="entry name" value="RNase_Zc3h12_NYN"/>
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        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF36">
        <property type="entry name" value="RIBONUCLEASE ZC3H12C-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF18561">
        <property type="entry name" value="Regnase_1_C"/>
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        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
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            <begin position="420"/>
            <end position="445"/>
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            <begin position="29"/>
            <end position="98"/>
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            <begin position="133"/>
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            <end position="232"/>
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            <begin position="474"/>
            <end position="504"/>
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            <begin position="693"/>
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            <begin position="786"/>
            <end position="914"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="718"/>
            <end position="735"/>
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            <end position="838"/>
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            <begin position="863"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010215.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="963" mass="104360" checksum="B68081AA642E8039" modified="2019-02-13" version="1">MGQKDHVEAGSGHILDLGLDLEYLHVAGGDRQAGGADGPPAMEEQGESTAGSPPLTVLEENSGFDAEGESALTSSSTLAPGTDSDGGDGGSTHSKNTHQPLCRTQCVDLGTEGPPEPPSELLAELECDAHAQSTLGSPSEHLPEPPPSLSASEPGYEAGGKEYQAKLEFALKLGYSEETVRLVLSKLGPDTLINDILGELVKLGTKSDSEQPAGLLASTSSSSSSSSSCGCSDLLEGQRPDSPCHSDSLCDQDNLRPVVIDGSNVAMSHGNKEVFSCQGIQLAVDWFLERGHQDITVFVPAWRKEQSRPDAPITDQDILRRLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAYESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKRPVMPEQKKQPCPYGKKCTYGHKCKYYHPERGAQPQRAVADELRASAKTCVVSKNQGDAGLVKSHSVPAGSIDAKKGAPKRQSDPSIRALSYSDAEEKLLAKGRLEVQKNTVCGSSSSSSTSGSCGGSVSMSPAPGGPPSTLGLPQEQQARPVMPHGHLPAPSHDLYPHCESPDLSYYSVTRAYTGLSLSSRRSPDCRFPNDTDLRLGSAGSECSSESSVSCGSSCDLYSERQCPGCPPDPLLEDAVHFPNPHSRLYSHHATSSHELCGLHPAEYTNIQHSHTPSTGLHPYHLSAAHGQSCAHDPPPLEAPPKRPLYPLPPHLQHQPLTARSSCPGDYHSLPQSNPAPPGSPLGRCLAPTRAESVSDSHLYEHLSTSHHRHRPKALPSWDKYYRQPPLPPSRYEPPTYQSLPDTRQSSWHTPPWTQDGYGQHHSSHPALHPSPTHYLSHPPPPAHSPCPPHPSSTPLPPYPPHSSHLTVPSHAPPSYMSQHPESPSHSRYGDAREKVYINLCNIFPSELVSRVMARSPHITDPQQLAAAILAEKAQTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BKT1</accession>
    <name>A0A3P9BKT1_9CICH</name>
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        <submittedName>
            <fullName evidence="6">NFKB repressing factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004545775.2"/>
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    <dbReference type="Ensembl" id="ENSMZET00005010921.1">
        <property type="protein sequence ID" value="ENSMZEP00005010549.1"/>
        <property type="gene ID" value="ENSMZEG00005007953.1"/>
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        <property type="component" value="LG2"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NFKB repressing factor"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
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        <property type="entry name" value="DSRM_CARF/NKRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
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    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
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    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034071">
        <property type="entry name" value="R3H_NRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF15">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26535">
        <property type="entry name" value="DSRM_CARF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="655"/>
            <end position="700"/>
        </location>
    </feature>
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        <location>
            <begin position="705"/>
            <end position="769"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="9"/>
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            <begin position="118"/>
            <end position="129"/>
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            <begin position="163"/>
            <end position="173"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="3">
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            <begin position="177"/>
            <end position="188"/>
        </location>
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        </location>
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        <location>
            <begin position="483"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010549.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="799" mass="89879" checksum="E83852A824244DE0" modified="2019-02-13" version="1">MAEGTDTGEMPSFEPSPSSEAKKRHISSDGREEPMRKMPLTKFGSRPRFEPVHFVSGGSSGGTYTDEKENDKERRRSELYSPRDSEHFSYNSSSRAQGSSSMRPAFDRVPAYTSDSWGSHRDRERDRDISSGSGLGYGSRGSSSNFLAKTQQEYTAKYEAQNFRSSDSYSQPPRYNGYGGGGRSGGWDSGRQGLGYSHQDRPSSSRLFSRVYNSPGRSSPNVSQSGSSLQPLPISQPTLDEKQRLIANVASALAVAFRDPMYMTGSDSPNYNFMLSRSIQACKTNPEYIYVSLKDIPQADLPKNKKVPTDGYACELRCQGVYLATGYSGSKNGARDRASEQAVKLFLKPVEVRVVQRKFRHTVVNDMVVCQLHSPTPAFLPALRNPEDKPTPSSKGQYEPDKHKHWTEFVVLDNAHDAICILNNSAAFNRMKIDYKFDLLPNSSKWLCSVFLQDELVAQAMGTKKSSKHAAAQEAVRKLRLNQAQQQQHQMQHQMQHQMQQQMQHQVQQQMQQQRQPQSQYSRGNIQSDFGGRFGQQGGKKKLSELVILENSDNAICIINDTAQFNKVTADYKFTVLPDHRWKCEVYLEGQYVAAGIGPKKIVKHIAAMEALVTLRQTQAVVKSNLRKEGHSDAISRSQIMGRSGEEATRQEIKEDNIGNQLLRKMGWKGGGLGRDGDGIAEPIRVKEQFSREGLGMDTDKTANQLSKRDIEDIIRSYASSDRQDDLRFSTDLTNDERKQIHQISQKYGLRSKSYGQGWQRFLVVSRKVHKDQLIGQLLQEGQVGRYELVKPQTSHEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BM41</accession>
    <name>A0A3P9BM41_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="35 36">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="31">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="31">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004539660.1">
        <property type="nucleotide sequence ID" value="XM_004539603.2"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005010988"/>
    <dbReference type="Ensembl" id="ENSMZET00005011367.1">
        <property type="protein sequence ID" value="ENSMZEP00005010988.1"/>
        <property type="gene ID" value="ENSMZEG00005008151.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479476"/>
    <dbReference type="KEGG" id="mze:101479476"/>
    <dbReference type="CTD" id="54822"/>
    <dbReference type="GeneTree" id="ENSGT00940000157091"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16971">
        <property type="entry name" value="Alpha_kinase_ChaK1_TRMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1010:FF:000002">
        <property type="entry name" value="Transient receptor potential cation channel subfamily M member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.200.10:FF:000001">
        <property type="entry name" value="Transient receptor potential cation channel, subfamily M, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000129">
        <property type="entry name" value="Transient receptor potential cation channel, subfamily M, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1010">
        <property type="entry name" value="TRPM, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057366">
        <property type="entry name" value="TRPM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029601">
        <property type="entry name" value="TRPM7_a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032415">
        <property type="entry name" value="TRPM_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037162">
        <property type="entry name" value="TRPM_tetra_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF8">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25508">
        <property type="entry name" value="TRPM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16519">
        <property type="entry name" value="TRPM_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 30" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="8" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="20 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 31" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 30" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 33" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="15 31" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="949"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1072"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-type protein kinase" evidence="34">
        <location>
            <begin position="1644"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="547"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1317"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1376"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1470"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="1880"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="1377"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="32">
        <location>
            <begin position="1424"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="32">
        <location>
            <begin position="1477"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="29">
        <location>
            <position position="1817"/>
        </location>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1674"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1698"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1770"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="1803"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1819"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="1827"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="1860"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="1862"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="31">
        <location>
            <position position="1866"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00025760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR629601-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR629601-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="PIRSR" id="PIRSR629601-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1909" mass="215924" checksum="D4A2678F74DC5740" modified="2019-02-13" version="1">MSQKSWIESTFTKRECVYILPVSKDPHRCLPGCQICQQLVRCCCGRLVRQHAGFTASLATKYSDVKLGESSNVPMPELEEWSVEKHTEARPTDAYGVINFQGGSHSYRAKYVRLSHDTRPDSILRLMLKEWHMELPKILISVHGGVQNFDLHPRIKQVIGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHCSRSSKKICTIGIAPWGVIENRNDLIGRDIIAPYQTLLNPLSKLNVLNSLHSHFLLVDDGTVGKYGAEVTLRRELEKHINLQKIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADILAYVHKQTEEGGGLPDGVETDIIATIKKTFNFSQGEAIHLFQTLMECMKSKELITVFHISSEEHQDIDVAILRALLQGTNASAFDQLVLTLAWDRVDIAKNHVFVYGQQLLVSSLEQAMLDALVMDRVDFVKLLIENGVSMHRFLTISRLEELYNTKQPPNNPTLLHLVRDVKQSHLPPNYKITLIDVGLVIEYLMGGTYRCNYTRKRFRIIYNNLHGNSRRSGRHTAGPGLRKSHESFSMQADKKEKTRHNHFIKTAQPYKPKLESSTEQKQKRSKEEIVDIDDPETRRFPYPFNELLVWAVLMKRQKMSLFLWQHGEENMAKALVACKLCRSMSYEAKKSDVVDDTSEELKEYSNEFGRLAVDLLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSHLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKSKAEMAHIPQSQDDHQMTMEDSEHNFQNIAEDIQMDVFKETRSHDHVETKSDMETHVRSRKLPLTRKIYAFYHAPIVKFWSNTLFYLGYLMLYTYVVLVKMSQWPTLQEWVVIVYIFTAAIEKIREMFMAEAGKISQKIKVWFSEYFNVSDFLAIVTFFIGCGLRLGGGDAFGPGRTVYCLNIIFWYVRLLDFLTVNQQAGPYVMMIAKMVANMFYIVVIMAIVLLSYGVPRKAILYPNEEPSWTLAKDVVFQPYWMMYGEVYAYEIDVCANNSDQSVKSLCTAGVWLTPFLQAVYLFVQYILMVNLLIAFFNNVYMQVKSISNLVWKYQRYHFIMAYHEKPVLPPPFILLCHIYSLFCMCRKRKKENIYGPKLFLTEEDQKKLHDFEEQCVETYFHEKDDQFHSGSEERIRLTSERVEVMCLQLKEVGNKVNFIKRSLHTLDSQIGHLQDLSALTVDTLKTLTVQRASEASKVHNQITRELSLSKNVVPSIAPMSTDTGPLSKSSVKGKSSVSAYFGSSFPQTGATIADALFGMGAERRAGTESRRRIGPSPASELGPDPTLNPALSPERRGLFGLGHLAAEVGSSSSADCRAFEQSVVPVSSSELRQRGHSLTQTKQTRPQEPGPSDSPSSLPNVPSPGVQFHISSTPSQPSGSSHSELALSGLYQHPLQSDSTSVEFGAFVGHKDSEELQHSLAKATPTSSKQQSPTPQTKSQAQPEGHTHIRAVNSYAGFTEFDRNPAFLHPDSTLTKKDRSRVSAEDILTHDDPRAAVLERIQVKSAQASSLRAPGEDTLTAAVSLYTPRHAHLGPRKDSIGSPFKPIESYQYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNTINNSMSSWAQRGLCAKIEFLSKEEMGGGLRRALKVLCTWSEYDILKPGHLYIVKSFLPEVVQTWQSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQIRPKTIPYSPRFLEVFLLYCHSAGQWFAIEECITGEFRKFNNNNGDEIIPTNLLEETMLAFSHWTYEYTRGELLVLDLQGVGEILTDPSVIKSGEKGSYDMIFGPANLGDDAIRNFRTKHHCNSCCRKLKLPDLKRNDYTPDKVTFPQEEPPSAGGGVKESRQSMRLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BN42</accession>
    <name>A0A3P9BN42_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="20">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="20"/>
    <dbReference type="RefSeq" id="XP_004545853.1">
        <property type="nucleotide sequence ID" value="XM_004545796.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BN42"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011350"/>
    <dbReference type="Ensembl" id="ENSMZET00005011744.1">
        <property type="protein sequence ID" value="ENSMZEP00005011350.1"/>
        <property type="gene ID" value="ENSMZEG00005008512.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467854"/>
    <dbReference type="CTD" id="695"/>
    <dbReference type="GeneTree" id="ENSGT00940000158469"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01238">
        <property type="entry name" value="PH_Btk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11906">
        <property type="entry name" value="SH3_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000053">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000040">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035574">
        <property type="entry name" value="BTK_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00779">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00107">
        <property type="entry name" value="BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="7 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 17" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 20" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="24">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="23">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="22">
        <location>
            <begin position="257"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="377"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="635" mass="73016" checksum="D34B6343CDD2542F" modified="2019-02-13" version="1">MSDSILEEVFIKRSQQKKKTSPLNYKERMFVLTAEKISYYDFDTDKMKRKGLKGSVDLEKIKCVEIVQPEPNAPQERMYPFQVIYDEGPLYIFSKTEDTRVAWIKKLKELVRFNSDLTQKYHPCFWVDGVWLCCHQEVKQAMGCKVLDSKNGVTSQLSRRSTRKPLPPTPAEKKPTRPLPPQPPDPPASSAGMTVVAEYSYTPMTPQDLELRKDEEYTILEKSDANWWRARDKYGKEGYIPSNYVVEAEDGLERFDWYCKNMNRSQAEKLLKAENKDGGFLVRDSSKAGKYTVSLLTRGGGEAVGSCRHYNICTTQQSQYYLAEKHNFNTIAELINYHQHNAAGMVSRLKHIVSNRARPPSTAGLGYGVWEIDPHLLTFIKELGSGQFGVVKYGKWQGQHDVAIKMIKEGSMSEDDFIEEAKIMMKLRHENLVQLYGVCTKQRPIYIVTEYLANGCLLTYLKEGLKQHPTSIQLLEMCKDVAEGMAYLESHQYIHRDLAARNCLVDGNGTVKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKSDIWAYGVLMWEVYTLGRLPYERLNNTEIVDQVSRGLRLFRPQLANERVYSIMSSCWLDKAEERPNFQELALTVQDLLYELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNB9</accession>
    <name>A0A3P9BNB9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNB9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011429"/>
    <dbReference type="Ensembl" id="ENSMZET00005011826.1">
        <property type="protein sequence ID" value="ENSMZEP00005011429.1"/>
        <property type="gene ID" value="ENSMZEG00005008571.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000276248"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="91" mass="9998" checksum="E55FEB4692E62E0F" modified="2019-02-13" version="1">FDHQCSNFAPDITSPMNSFGVKNFIKTVIKESLSVSLSFLDQDRSGYIEQGELQLKLCEGARPLTPADTRAFLLEGDLDGDGEIGWEGQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNK0</accession>
    <name>A0A3P9BNK0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BCL6A transcription repressor a</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
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        <location>
            <begin position="510"/>
            <end position="538"/>
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            <begin position="566"/>
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            <begin position="594"/>
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            <begin position="408"/>
            <end position="433"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="326"/>
            <end position="345"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <begin position="346"/>
            <end position="367"/>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="698" mass="78469" checksum="208E5181EFEFB7B2" modified="2019-02-13" version="1">MACAADSCIQFTRHASDVLLNLNRLRSRDILTDVTILVNRQQFRAHKTVLMACSGLFYTIFTDSHKCNLSAISLDPKVDPEGFAILLEFMYTSRLTLKESLIMAIMNTAIYLQMDHVVDTCHRFIKSSDPTVKLPRDEFLVSPLVLPQDVHAYRAHDVVDSLHSRVAPFRDGRHYGSNMFSGVSTPSNYHLYGQFPMPGFPFPLCKLADTKNAFADLSKSSIHHKHCPPHDSGIRADYSRAIGTNSSGIIHSTTYASREVVRDDEMRKESHEGVSQSVGFSTRKRAFPMLSLEHQKDLGKEHAPQAEEDLIHQHYPLGISAGRKSLMSSPQSPLKSDCQPNSPTESSSSKNASLSQAAGAQTPQGTQDPKARNWKKYKFIVLNQSAKEDKVGLRDPGLHSPQRLALQPYLHPNDSENLDPQTTSKSNSEDLPVPQASRLNNIINSALEGSLRNGDGHPPHYLNRLTCSSCGSQSPQHSEVCPNHSRSRLSEEMSELHSEYSDSSCENGTFFCNECDSKFAEDEALKQHMLQVHSDKPYKCDRCQAAFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKIQYRMSTVDMPTDLTKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNL5</accession>
    <name>A0A3P9BNL5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Anoctamin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the anoctamin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004548234.2">
        <property type="nucleotide sequence ID" value="XM_004548177.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNL5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011517"/>
    <dbReference type="Ensembl" id="ENSMZET00005011918.1">
        <property type="protein sequence ID" value="ENSMZEP00005011517.1"/>
        <property type="gene ID" value="ENSMZEG00005008619.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482106"/>
    <dbReference type="GeneTree" id="ENSGT00940000158969"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061590">
        <property type="term" value="P:calcium activated phosphatidylcholine scrambling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061589">
        <property type="term" value="P:calcium activated phosphatidylserine scrambling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002040">
        <property type="term" value="P:sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032394">
        <property type="entry name" value="Anoct_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF21">
        <property type="entry name" value="ANOCTAMIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16178">
        <property type="entry name" value="Anoct_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin dimerisation" evidence="10">
        <location>
            <begin position="63"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="9">
        <location>
            <begin position="289"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="901" mass="105477" checksum="C175465AAB931F2C" modified="2019-02-13" version="1">MSDHDILEMESDMEDLGDIELGMIEEEVVYPEEFLPTYHSIKEGGNVIKAQEVGFNDKPDSLFFNDGVRRIDFVLAYEDEDKKEYEKRHVFQRRKRRREYFEASLMKMGMELEATQSVLDEKLMFLKVHMPWDVLCTYAEVLHIKLPIQPNDMPARPSPLRFFSCITKHFYPDEKLISKESEFFTAPFEKDRQDLFCIKDKDLFFTPSMRSRMAYYILSRAPYDIRGNIKKFGITKLLDSGVYKAAYPIHDCRFNVKSQEPECPNERYLLYEEWAHPKSFYKIQPLDLIRNYYGEKIGIYFAWLGFYTRMLTWAAVVGIGCFIYGYYTRDTSTWSKEVCDPDIGGKIVMCPQCDTCQYWTLNSTCNTSKNLCIFDNFGTLVFAVFMSVWVTLFLEFWKRYQAELEYEWDTVEFLEQEEPPRPEYEAKCIYERKNPITGVKEKVPYTACGRCVRVSIGMTTVVFWIMLILASVVAITVYRLAVFFTFSRELRNTNLTIAEPIKEYVTPQMATSVTASLISFVVIMILNILYERVAIWITDFELPRTKTDYENSLTLKMFLFQFVNYYSSCFYIAFAKGKAVGHPGKPVYLLGKYRNEECDPGGCLIELTTQLAIIMGGKAIWNNIQEVLIPWLKNLIYRHCVHVTSEKVIPRWEQDYQLQPSSKLGLFYEYLEMAIQFGFVTLFVASFPLAPALALLNNIIEIRVDAWKITTQFRRDVPEKAQHIGAWQPILQGITILAVVTNAMIIAFTSDMIPRLVYYWSFSVYPYGNNTENTMKGYINSSLSVFSTNDFPPVDDEYIHTPPNLTTCRYRDYRFPPGHQRQYEYNMFYWHVIAAKMAFIIVVEHIVYFTKFILAYIIPDVPYAVKEQIKREKYLTQVILHETNLKLVSKRLKATETETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRS8</accession>
    <name>A0A3P9BRS8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein transport protein SEC61 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein Sec61 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63. The SEC61 channel associates with the multi-pass translocon (MPT) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545398.1">
        <property type="nucleotide sequence ID" value="XM_004545341.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRS8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012627"/>
    <dbReference type="Ensembl" id="ENSMZET00005013071.1">
        <property type="protein sequence ID" value="ENSMZEP00005012627.1"/>
        <property type="gene ID" value="ENSMZEG00005009480.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467346"/>
    <dbReference type="KEGG" id="mze:101467346"/>
    <dbReference type="GeneTree" id="ENSGT00390000003721"/>
    <dbReference type="OrthoDB" id="8385868at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048793">
        <property type="term" value="P:pronephros development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="7 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="18">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="476" mass="52314" checksum="82BFF1621651A531" modified="2019-02-13" version="1">MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPSEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGTEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSTRFSGNFLVNLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLDDPVHAVIYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGGLSVMADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMSALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BS48</accession>
    <name>A0A3P9BS48_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SRY-box transcription factor 14</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_004552868.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BS48"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012755"/>
    <dbReference type="Ensembl" id="ENSMZET00005013199.1">
        <property type="protein sequence ID" value="ENSMZEP00005012755.1"/>
        <property type="gene ID" value="ENSMZEG00005009572.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484987"/>
    <dbReference type="KEGG" id="mze:101484987"/>
    <dbReference type="CTD" id="8403"/>
    <dbReference type="GeneTree" id="ENSGT00940000160749"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="transcription factor Sox-2"/>
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        <property type="entry name" value="High mobility group box domain"/>
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        <property type="entry name" value="SOX_fam"/>
    </dbReference>
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        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
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    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF107">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
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    </dbReference>
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        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="238" mass="26607" checksum="7B135115A59A9647" modified="2019-02-13" version="1">MSKPADHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLSESEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDHLKGLPVSAADSLLGSSEKARAFLPPTSAPYSFLDPSQFSSSAIQKMTEMPHTLSTSTLPYASSLGYQNGAFGTLGCPSQHTHTHPSPTNPGYVVPCNCTAWSTSSLQPPVAYILFPGMTKTGIDPYSSAHATAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSG0</accession>
    <name>A0A3P9BSG0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dedicator of cytokinesis 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DOCK family.</text>
    </comment>
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    <dbReference type="Ensembl" id="ENSMZET00005013339.1">
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        <property type="gene ID" value="ENSMZEG00005009466.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155514"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08695">
        <property type="entry name" value="C2_Dock-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.350:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000003">
        <property type="entry name" value="Dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037811">
        <property type="entry name" value="C2_Dock-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF4">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="407"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1204"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1644"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1697"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1652"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1702"/>
            <end position="1719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1831" mass="212011" checksum="A136D30AF23212E6" modified="2019-02-13" version="1">MPWTPLSSSFYRISSFPISLILSTVICNFRGSVTQGLALEVGETVQILEKCEGKGVFPASYVHLKKAIVTNRGPHETVVPLEDPIVTEVTSTLQEWALLWKQLYVKHKVDLFYKVRHVMMELIDLRRQLLSGHLTQDQSRDVKRHITVRLDWGNEHLGLDLVPRKEFEMVDEDQISVSDLYKMVSQVTPRHGEPCRVPVPHHLLVNLKSFTYNSIGEDTDIFFSLYDLREGKTLSEKFMVRLNKNGGPKNPEKVDRLCALFTDLSNKDMKRDLYIVSQVIRTGRMLLNDSKKGPPHVQYRRPYGCAVLAMSDVLQTISELKEEKDFVLKVYTCNNENEWYQIHENIIRKSSTKYTAPSTNYGLIISLQLLRGDMEQVRRENPLIFSRGVAITRKLGFPDVIMPGDIRNDLYLTLERGDFERGGKSVQKNIEVTIYVLYADGEILKDCISLGSGEPNVPEHRSFVLYHNNSPRWSEVIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFTPLMREDGTTLSDESHELYVYKCDENTTFSNHALYLGLPCCKEDFNSCPNIPSSLIFQRSMKETFWISTQLSSTKLTQNVDLLALLKWKAHPDRVMDILGRLRHVSGEEIVKFLQDILDTLFSILDDNTDKYGPLVFQSLVFIINLLRDSKYYHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDRSAEVVRQDHIQEAMRALEYLFKFIIQSRILYSRATCGMEEEQFRTSVQELFQSIRFVLSLDSRNSETLIFTQAALLNSFPAIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFPESRRILLPVVLHHIHLHLRQQKELLICSGILSSIFSIIKTSSLDTSVQEEVEMMVESLLDVLLQTLLSIMSKSQSQEAVRGQRCPQCTAEIGEYVSCLLSLLRQMTDIHFQHLMENFQSKDELKEFLLKIMCVFRNLMKLSIFPRDWNIMRLLTSNIILTTVQYLSPALHKNFTEADFDFKVWNSYFSLAVLYINQPSLQLENLSPAKRKKVLDKYGDMRVMMTYELFSMWQNLGENKIHFIPGMIGPFLGVTLVPQVEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSLVSEGKGDENYRELFGLLLLEKIEQETWRETGISFVTSVTRLMERLLDYRDCMKGDETENKKIGCTVNLLNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYWELLHWDERPLKEFLHYPSQTEWHRKEGLCRKVIHYFNKGKCWEYGIPLCRELAFQYESLYDYQSLSWIRKMEAAYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEFVCRGHDYERLEAFQQRMLGEFPQAIAMQHPNQPDEAILQCDAQYLQIYAVTPVPDSVTVLQMDRVPDRIKSFYRVNNVRRFRYDRPFHKGPKDRDNEFKSLWIERTTLILTHPLPGISRWFEVEKRELVEVSPLENAISVVENKNQELRTLISQYQHKQLHGNINLLSMTLNGVIDAAVNGGIARYQEAFFDKEYITSHPEDTEKITQLKDLMQEQVHILGVGLAVHEKLVHPEMRPLHKKLIDQFQMMRSSLCHGLPGLDKSGSGPNTPRGILATHGPMSPESFKLMHRHRSATPVLTPVRNSSSSLSSHNSSEMGNVGNLLILADGMVVEHPEDFYRMQVSEKRDSQRGNALASLSSSSLSSTHSAPSQMINSAPSTIRVGSPSLPDKYRHNREMLMLLPPHRERPSSAMYTNITDNGQPPNFQRALFHQVIGPCKPCSDPNLSVAEKGQHLSMHFDAFHHQVSDLPPALPARSLRKVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BUQ4</accession>
    <name>A0A3P9BUQ4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tumor necrosis factor ligand superfamily member 13B</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BUQ4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013614"/>
    <dbReference type="Ensembl" id="ENSMZET00005014079.1">
        <property type="protein sequence ID" value="ENSMZEP00005013614.1"/>
        <property type="gene ID" value="ENSMZEG00005010245.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157536"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051748">
        <property type="entry name" value="TNF_Ligand_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15151:SF24">
        <property type="entry name" value="A PROLIFERATION-INDUCING LIGAND-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15151">
        <property type="entry name" value="PROTEIN EIGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018325262" evidence="7">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="8">
        <location>
            <begin position="75"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="209" mass="23366" checksum="A99E552F65CA5F54" modified="2019-02-13" version="1">MLYNALLSLTAFMFCLSLFLVHRARVLENDFRKLQGDIILQLNQPCSEGVDGKLAKMLKTSESSVYFLLLPASTAFLQLRADTNKRPDIRGNITVISWIVSAQRGTAISQKENRIVVQEDGYYLVFGQVLFESPSIVMGHVVRSRASAEAELLRCLQAMPDRYPANTCYTAGTVQLLQDDELELVIPDRPTALISTDEDSTFFGVIQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BX92</accession>
    <name>A0A3P9BX92_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 25 member 44a</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014266695.1">
        <property type="nucleotide sequence ID" value="XM_014411209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BX92"/>
    <dbReference type="Ensembl" id="ENSMZET00005014996.1">
        <property type="protein sequence ID" value="ENSMZEP00005014514.1"/>
        <property type="gene ID" value="ENSMZEG00005010921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474466"/>
    <dbReference type="KEGG" id="mze:101474466"/>
    <dbReference type="CTD" id="492478"/>
    <dbReference type="GeneTree" id="ENSGT00940000155399"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042164">
        <property type="entry name" value="SLC25A44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46314:SF2">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="107"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="223"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="317" mass="35207" checksum="17E6DAB87B44C17F" modified="2019-02-13" version="1">MQQKGAIQIIEWEDLDKRKFYSLGVFMTLTTRATVYPASVIRTRLQVQKGKSLYSGTFDAFCKILRTEGVRGLYRGFMVNTLTLIAGQGYITTYELVRKYVNQYSPSNTVKSVVAGGMASLVAQTITVPIDIVSQHLMMQGQGEHLTRFKAKPKVGLATTKHKLSFGQSRDITVQIFSADGFRGFYRGYVASLLTYIPNSALWWPFYHFYAEQLSLLAPSECPHLILQAVAGPMAAVTASTITNPMDVVRARVQVEGRTSVIGTFKQLLVEEGAYGLTKGLSARVISSTPTSVLIVVGYETLKRLSLRADLIESRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYQ9</accession>
    <name>A0A3P9BYQ9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RUN and FYVE domain containing 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_024657864.1">
        <property type="nucleotide sequence ID" value="XM_024802096.1"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005015118"/>
    <dbReference type="Ensembl" id="ENSMZET00005015608.1">
        <property type="protein sequence ID" value="ENSMZEP00005015118.1"/>
        <property type="gene ID" value="ENSMZEG00005011330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477784"/>
    <dbReference type="CTD" id="55680"/>
    <dbReference type="GeneTree" id="ENSGT00940000155595"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15759">
        <property type="entry name" value="FYVE_RUFY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17695">
        <property type="entry name" value="RUN_RUFY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000001">
        <property type="entry name" value="RUN and FYVE domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RUN and FYVE domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047333">
        <property type="entry name" value="FYVE_RUFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047332">
        <property type="entry name" value="RUN_RUFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF3">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="131"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="636"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="393"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="702" mass="79922" checksum="1C6F5BC9C03F0254" modified="2019-02-13" version="1">MASSAEHDLSLSEADSSKDKSQVFGILRLQEEKAAAGDKANSSSTVRGGGGGDGRWQAPIFALARKASETISGSIHVLPKVSEHRTSLPGDWAVQALRDPMAMERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLRVKKSFLGFNKSLWGPLELVEKLCPEAAEISASVRDLPGLKTPLGRARAWLRLALMQKRLADYLRLLITRKDLLSDFYENSALMLEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNDIDDYRSEERNSQIASILDQKNYVEELNRQLNSTVHGLQGRVDSLEKSNSKLIEELAIAKNNIIKLQEENQQLRSENTLILLKTQQHLELTQGDVSVERDTYKQSRQGLDEMYNEVRRQLKEECQLRQDVENELVVQVSMKQEMELAMKLLEKDIHEKQDTLIGLRQQLDEVKAINVEMYQKMQSSDEEMKKKNDVISRLEEKTNQITATMKQLEQRLQEAERHRTSAEEGTRRFKLDFANKADSLQRQIEHREKQLQQLETDLKIEREWRQTLQNDLHRERDSVAQLSTEALQINGLKKEFHRLQDENVQLKTICEDQEKALEELGSKLSESKLKIEDIKEANKALQGGQVWLKDKEATHCKLCEKEFSISRRKHHCRNCGEIFCNSCSDNELPLPASPKPVRVCDTCHALLLQRCSSNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYU0</accession>
    <name>A0A3P9BYU0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Axin 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
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        <scope>IDENTIFICATION</scope>
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            <taxon>Cichliformes</taxon>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Noh H.J."/>
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                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16040">
        <property type="entry name" value="SPRY_PRY_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001524">
        <property type="entry name" value="Si:dkey-126g1.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029495">
        <property type="entry name" value="NACHT-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14484">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01288">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="8">
        <location>
            <begin position="121"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="685"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="98102" checksum="F2BEDAA758C86CCE" modified="2019-02-13" version="1">RRAQSWEQLRYCAGPSSSQASDFHSFVPLGIPMGGLEPNLKSFLKKKFQCVSEGIAKSGKTTLLNQIYTELYIIEGGTAEVNDEHEVRQIETASRKIDSLETTIGQEDIFKASPGRDKPIRTVLTKGVAGIGKTFLTQKYTLDWAEDKANKDIQFIFPFTFRELNVLKEEKFSLVELVHHLFTETKEAGICNFEDFQVVFIFDGLDECRLPLNFHKTKILTDPRKSTSVDIPPDCVDMVTEVRGFTNPQKEEYFRKRFRDKKANMIISHIKTSRSLHIMCHIPVFCWITATVLEDVLRTREKGTLPKTLTEMYIHFLVVQAKVKKVKYDEGAETDPHWTPESRKMIESLGKLAFDQLQKGNLIFYESDLTECGIDIKAASVYSGVFTQIFKEERGLYQDRVYCFIHLSVQEFLAALHVHLTFINSAVNLAVDKALQSPNGHLDLLLRFLLGLSLQTNQTLLQGLLTQTGSSSQTNKKTVQYIKERISENLSAEKSINLFHCLNELNDHSLVEEIQKCMKSRSLSTAKLSSAQWSALVFILLSSEKDLDVFDLKKYSASDEAPQRLLPVVKASDKALLDGCNLSGRSCAALSSVLNFQSSSLRELDLSNNDLQDLGAKLFSEGLKDPHCKLESLSLSGCLITEKGCTSLASALSSNPSHLRELDMSYNHPEASGINLLLAGLKDPYDGSITAAGLCLFSPSDSCQLTIDTNTVHTNLQLSDNYTTVKHVEKVQSYPDHPDRFDVWPQLLCSNELTGRCYWEVEWSGRVDMSVSYRRIRRKGDSYDCVFGYNDQSWSLNCTDNGPDSVCHANSRTSISSSVSNRVAVYVDCPAGTLSFYKVSSDTLIHLHTFNTTFTETLYPAFYFFPCASVCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0V2</accession>
    <name>A0A3P9C0V2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B-cell translocation gene 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551192.1">
        <property type="nucleotide sequence ID" value="XM_004551135.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0V2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015727"/>
    <dbReference type="Ensembl" id="ENSMZET00005016235.1">
        <property type="protein sequence ID" value="ENSMZEP00005015727.1"/>
        <property type="gene ID" value="ENSMZEG00005011810.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473416"/>
    <dbReference type="KEGG" id="mze:101473416"/>
    <dbReference type="CTD" id="54766"/>
    <dbReference type="GeneTree" id="ENSGT00950000182952"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.90:FF:000002">
        <property type="entry name" value="BTG anti-proliferation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF5">
        <property type="entry name" value="PROTEIN BTG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="264" mass="29439" checksum="3060A2B1114F0C14" modified="2019-02-13" version="1">MKEEIAAAVFFLARLVKRYGCLDNDSRERFAASLTSLLFENYKNHWHPSAPARGQAYRCLRMNSVRLQDPVLEQVCERSGVRYEDLGLPQELTVWVDPGEVSCRYGEHSSPFCVSVVDNCRRGDGELSRRIHEAVERASLEVPSGSSSDEDEDGGGDNSMSMSTSSSSLSTLCPQIPPMNSEPKTIPTVSNPNSVYRFSEFSPGAPQSWLREKRKGFPGDMFPPHGAPAGAHFSSQKGFRSYRATFTFTGPRVDKYHWVSKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C231</accession>
    <name>A0A3P9C231_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PPFIA binding protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the liprin family. Liprin-beta subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C231"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016303"/>
    <dbReference type="Ensembl" id="ENSMZET00005016823.1">
        <property type="protein sequence ID" value="ENSMZEP00005016303.1"/>
        <property type="gene ID" value="ENSMZEG00005012230.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244951"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09563">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09566">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09569">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000005">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000007">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000017">
        <property type="entry name" value="Liprin-beta-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058914">
        <property type="entry name" value="LIPB1/2_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037617">
        <property type="entry name" value="LIPB1/2_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037618">
        <property type="entry name" value="LIPB1/2_SAM_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037619">
        <property type="entry name" value="LIPB1/2_SAM_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF18">
        <property type="entry name" value="LIPRIN-BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26022">
        <property type="entry name" value="CC_Liprin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="486"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="563"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="778"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="145"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="813" mass="90351" checksum="ABB2E4830C43ED6D" modified="2019-02-13" version="1">MNKELLHRASLENQKLSLMGEVSYLKLKLADMEGKQGHGGERQHKAETVVNFISELQEQIYQFQKEINSKIQEKKALEIPNDSRLPVECPAESSESQDSNLGVPCDKTSGIVNKLEDTPNGADGNTTTLEEGSSDAEQKYYCGGESGLLKELRILKDKVEHLEDQKLQYEKKLKATKAEISSLQQLLHSKNAEIESLHSQLLARPSLTTESTERDQELQKLRSGMKSLAAANDEKDRRIEELTLLLNQCRQFREVSSKARQAPSAVRTLSNGRSLSSSSEEEEQGLMKNGDTSSAKSEDVKSEASTNSSASQQTSISSVQKDSDSRSEVQTLSSSMNDITNGSAQKTGPSEMRSHTLPVNSSLSEQNGIGDSSSEIQSQRSPAGSEDGDSSQRKPEKGDDSTSSDTSPVHSGQRAVGSPEYMKNNRSFKRLWGKLRRTQSGGLPATDPDSGQFRRGGLRATAGPRLTRTPESFDSARDMNIPFSQWTKEQVCGWLEDYGLGQYVSLSRQWVENGQTLLSATPQDFEKEMGLKNPLHRKKLQLALRAFTTKAIEKSSELDHIWVTRWLDDIGLPQYKDQFHEARIDGRMIQYLTVNDLLTLKVTSQLHHLSIKCAIHVLHANKFNPNCLRRRPVEEKHPPPSEVVQWSNHCVMEWLRAVDLAEYAPNLRGSGVHGGLIILEPRFSSETLALLLNIPPQKTLLRRHLATAFSALVGLQAMQEKREYGNATGHVPLTTTAKVKPKKLGFTQFSHLRKRKPDESADYICPIDSGALTVNGVSRLPSSAQRGLSPRLDRQAEREEQVGIKAQTNGPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2N5</accession>
    <name>A0A3P9C2N5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2N5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016508"/>
    <dbReference type="Ensembl" id="ENSMZET00005017031.1">
        <property type="protein sequence ID" value="ENSMZEP00005016508.1"/>
        <property type="gene ID" value="ENSMZEG00005012389.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155366"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098560">
        <property type="term" value="C:cytoplasmic side of late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098574">
        <property type="term" value="C:cytoplasmic side of lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF28">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="10">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="164" mass="18254" checksum="2E9B91F4DB48B94F" modified="2019-02-13" version="1">MESNVDKLFPAPTPYFLPEDCKSDQDVKVYKVHSPFTRPPPPPAQPPQPPSSSSGVCLPNNILSAVPVYDAPLRTPRAKFVSYEAELRCSPGLATCPSCRTRVTTEVTFKAGTFAWLVCLVFVLCGLVLGCCLIPFFVNHFKDAYHSCPRCRRVLHVHKKRCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C562</accession>
    <name>A0A3P9C562_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 8B</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546990.1">
        <property type="nucleotide sequence ID" value="XM_004546933.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C562"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017237"/>
    <dbReference type="Ensembl" id="ENSMZET00005017783.1">
        <property type="protein sequence ID" value="ENSMZEP00005017237.1"/>
        <property type="gene ID" value="ENSMZEG00005012954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475726"/>
    <dbReference type="KEGG" id="mze:101475726"/>
    <dbReference type="CTD" id="51754"/>
    <dbReference type="GeneTree" id="ENSGT00940000157861"/>
    <dbReference type="OrthoDB" id="69646at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319">
        <property type="entry name" value="FIVE-SPAN TRANSMEMBRANE PROTEIN M83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8 9">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="803" mass="90169" checksum="02A9F80BA9FCA8D4" modified="2019-02-13" version="1">MWQLERLGSGCSPPRLLLLVYTYLCAVGDCLFVTEYFTRTPRKLSAFNSFASVELFHFNVPDDTMMAVWNLITFKEQGGTFGDSCPNRNVTVYFRSGAPPVINPLFTRFPRDTVIPGSFAVTLTWTLPNRTTGAFNVTSPLPGDWFLAAHLPKDEGKISVKGLSEECQYLFQPQLIVQRLIGISVLYPGYFIDQMIPVHNRSALYKVFIPNYISKVKVQLVNCSTKNKSSDSCPVVLKIRARAPPVHNSSALDCREWNPCELVTLVPAWEQWYYILVERYLSNSDVYFRIGVQVTDCSKPSLLKDQAQPSSSMNMPQSFGTAMGFSLSDTLLMAALPSLSQNSSHLHTSEDSIIYLAPTADTNKCWPIRPTLRNELDTFSVHFYVFFGPNISIPPDRAAVFAVNLMPVLDSGGVLNMELKLNMSTLKGANLTVFGCLNHGMPLFLRENTSLKCESESVAGFFLSVNTSTNITKLRIPYPQTGTWYLSLRSLCATEHGFEQCSNVTAEVYMRAYLTPCINDCGTYGQCKLLRTNNYLYAACECKAGWDGWGCTDNSEAYSYSFQLLSTLLLCLSNLMFVPPVAIAIRSHYLLEASVYIFTMFFSTFYHACDQPGIVVFCIMEYDVLQFCDFLGSLMSVWVTVIAMARLKSIIKQVLYLLGAMSLSMALQLDRHGLWNLLGPSLFALGIMAVAWTVRTIRRRRCYPPTWKRWVFFLFPGTMIATSAVALYAFVETEENYFYIHSIWHMLIAGSVGFLLPPRAKPDAKVTPLKRRRGCGYQLCVNEHEELGLVDPGIISINSICTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7Y7</accession>
    <name>A0A3P9C7Y7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transforming growth factor beta regulator 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004543979.2">
        <property type="nucleotide sequence ID" value="XM_004543922.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7Y7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018026"/>
    <dbReference type="Ensembl" id="ENSMZET00005018614.1">
        <property type="protein sequence ID" value="ENSMZEP00005018026.1"/>
        <property type="gene ID" value="ENSMZEG00005013545.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101486367"/>
    <dbReference type="CTD" id="84897"/>
    <dbReference type="GeneTree" id="ENSGT00390000013374"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056515">
        <property type="entry name" value="INO80E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040092">
        <property type="entry name" value="TBRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22715:SF0">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR BETA REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24237">
        <property type="entry name" value="INO80E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00542">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="5">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="590" mass="65118" checksum="70494FB0523782C5" modified="2019-02-13" version="1">MLAFSRSDCKQCNEDGRRFRLTRKLIVRSTKSNKCLLQFHLDALPSMESLNTFESEMEADGQGNYSLFPALDSIATLSGTTETLESEPPSEIAEKPNLTWLDAAQIVLEEAGGPMHIKEIKQRIIDRGLVQSNAKSSLEAVMYRETQKGSRRFKRIENRNGVFALLTDEERQQALQAFTAQSFLSSPQQNTISGSGSGVSAPTFPSPTTSSEHKAKGKRGPRKNQNEKYRLKYLRLRKAARAMIFENAALCDEVAHIEEKFLRAKEERRFLLKSLLQYQSLSEGELLPTPSSSAHLPLPPVALSSGPSGASGLSTTHSVSSTVPTGEEGALKKPKKERKERGRENGKDELPKKMSKKRKLADGSRKVVQPIPLDSSGRPVFPIVLGGLTVYSLGEIITDRMLFHDECAIYPVGFCSTRIFASMKNPEQQCLYTCQIKDGGTGPQFEIVPEEDPQNAIVASSALTCHANLLKAIASVSSKSMVSIVPSGADFFGFSHPTIQNLIQSCPGARKCSNYRWIRFEVCRPGDGQVPHSLSEDDASINFEAFQRHHGFENIKIEHITGQTPQSPSLSHQHHLTSPTMKASTSYFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8V0</accession>
    <name>A0A3P9C8V0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TNF superfamily member 14</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559600.1">
        <property type="nucleotide sequence ID" value="XM_004559543.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014264365.1">
        <property type="nucleotide sequence ID" value="XM_014408879.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8V0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018331"/>
    <dbReference type="Ensembl" id="ENSMZET00005018923.1">
        <property type="protein sequence ID" value="ENSMZEP00005018331.1"/>
        <property type="gene ID" value="ENSMZEG00005013766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474602"/>
    <dbReference type="KEGG" id="mze:101474602"/>
    <dbReference type="GeneTree" id="ENSGT01060000248544"/>
    <dbReference type="OrthoDB" id="6072476at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF34">
        <property type="entry name" value="TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="6">
        <location>
            <begin position="93"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="228" mass="25873" checksum="1C128D4F7F2ECBD2" modified="2019-02-13" version="1">MEKIKYPSVCVVDTHATRPPVPPRLIQMRKKTGVAQILLFMLVSVALCGMVIEACFIYGLYQAEHTDSESISKLIRVTTATEQPSYAIPPSKPVAHLTDGQDVAHAKNKMAWSMNADPLLYEMTYKDRELKIEKEGYYYVYSKVFFSDSNGFQHRISMHTDRYSGNITLLQSRKYPSHSKVSQKTQSNSYLGGVFHLYKDDGIFVDVSDTAKIVRHKPSENVFGAYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9G8</accession>
    <name>A0A3P9C9G8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urotensin-2 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Urotensin II receptor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9G8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018923"/>
    <dbReference type="Ensembl" id="ENSMZET00005019530.1">
        <property type="protein sequence ID" value="ENSMZEP00005018923.1"/>
        <property type="gene ID" value="ENSMZEG00005014196.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157017"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001604">
        <property type="term" value="F:urotensin II receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14999">
        <property type="entry name" value="7tmA_UII-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000687">
        <property type="entry name" value="Si:ch73-379f7.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000670">
        <property type="entry name" value="Urot_II_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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            <begin position="6"/>
            <end position="31"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="312" mass="34747" checksum="1515815C864724C5" modified="2019-02-13" version="1">SGGLWVTFLLGTTLIIMCVVGMSGNTYTLIVTRSAALRRTGSMYVYIINLALADLLYLCTIPFVVCTYFAHDWLFGEAGCRILLSLDLLTMHASVFILGVMSLERYRAVAKPFSAHKTSSRNRRLVSGIIWGLSFLLTLPMMVMIRLREGKPTVAGSVKRICYPTWTPEAFKAYIIALFFTSVLVPGLVIVGLYAGLARRYWVAQANLGGSSHSARRTRLKQKVVSMIFSIVVAYWTCFLPFWGWQLAKLFSPESLKALSPAAHNYVNFFVTCLTYGNSCINPFLYTLLTRNYKDYLAQKGQSSGSSRADPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9N9</accession>
    <name>A0A3P9C9N9_9CICH</name>
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        <recommendedName>
            <fullName evidence="11">ascorbate ferrireductase (transmembrane)</fullName>
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        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
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        <property type="gene ID" value="ENSMZEG00005013976.1"/>
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        <property type="component" value="LG10"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
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            <end position="159"/>
        </location>
    </feature>
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    </feature>
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            <begin position="244"/>
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        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="61"/>
            <end position="270"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="274" mass="30426" checksum="5C82EA6CF0170B32" modified="2019-02-13" version="1">MRAPDPADRFSXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXHSSHPRPLAADGHIFLMTRWSKRAAVALLAWLSKPLKGIFQVMDGDVVSCYPFTNICFLSLQYCLCMTEGILLFSAEGSPFCFKSWKSKVRLHWFCQALVLIAAATGLGFIVASRNVSELPHLASWHSLLGMCTLTATVLQTACGIAVIFPKLLRLSCPSSRLKLYHATCGLVVYLFSTVTVMSAMFTDWFQATAKGVAWWAFLILPLFPALVVMSQITNAYLPARILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBR9</accession>
    <name>A0A3P9CBR9_9CICH</name>
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        <submittedName>
            <fullName evidence="5">Pleckstrin homology and RhoGEF domain containing G3</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
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        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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                <person name="Streelman J.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="SIMILAR TO HUMAN CHROMOSOME 6 OPEN READING FRAME 52"/>
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        <property type="entry name" value="Trnau1ap"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="340" mass="37692" checksum="FF34D5AD477AC5A1" modified="2019-02-13" version="1">MMFNRQTSLWMGDLDPYMDENFIKQAFSAMGESPFGVKIITHRITGGSAGYCFVELADEASVERCVQRLNGKLVPGSNPPRKFKLNYATYGKRPEAGPEFSVFVGDLASEIDDFQLHQVFKKYPSCKGAKVVTDQYGYSRGYGFVKFGEESEQKKAIEECQGTMLGGKPLRLSIAVAKSQKMSSYHGGQGQNYQSNYNQTQSGYYGSHSGGSQGYYSQWGGYDQYGGYNSTGYNSGYGSGYNSGYNYGYGAYGYPPPGHMMPPPPMGMPPMSTDMSGAVEQSHVEAEDIDEDNAEEPIPECDVDLWNKDFMQRSEELYDAMMNCHWEALDSVDSPIPSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCT7</accession>
    <name>A0A3P9CCT7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CCT7"/>
    <dbReference type="Ensembl" id="ENSMZET00005020327.1">
        <property type="protein sequence ID" value="ENSMZEP00005019696.1"/>
        <property type="gene ID" value="ENSMZEG00005014785.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000245001"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="52147" checksum="F2A5940A1D446989" modified="2019-02-13" version="1">MPSLSTDDYHSLLQKIAVLETKIHRLEVNVEVNGLCGNETTLPLIQNNGDEQASTQLRSTDNMTKKVDSVHYYKSSSDNPPLDCLGAKPRHKSCLLEGGGRITGRAQRAEISETDWPSLPTRQRSSSTPVYGRKQDWTTVNRKVNNKPPKQLNVKLQNRFAPLSKDPGSISDNHPSKSSEIRSENLLKSERPQGKLKARPETLIVGDSAVKDVQKMCGKNTKVLCFPNDMVNNLKERILQIADEYPTVTNIVLHTGSNDVSKQQSEVLKRDFTGLLNTVNSLNAAVFISGPVPPVRGGDERFSRLFTLNKWLISACADHSVHFIDNFNIFWERRHLFKANGFNFNKSGVKLFTSNLFYSIRHPSVLGAKAEINEELSHKEEQTVLQEQTKPSRNLEEELHLPPPGKSLRKERHPWHLRKSLRKERHLRQEEGSLFASNSLNNTNDQDKGPRPSPVPQTPDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDF9</accession>
    <name>A0A3P9CDF9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Trace amine associated receptor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDF9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019911"/>
    <dbReference type="Ensembl" id="ENSMZET00005020556.1">
        <property type="protein sequence ID" value="ENSMZEP00005019911.1"/>
        <property type="gene ID" value="ENSMZEG00005014950.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182934"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001594">
        <property type="term" value="F:trace-amine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF415">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="309" mass="34978" checksum="6BEFDC6DE7B02720" modified="2019-02-13" version="1">MELFNVTVNTVSFLLCDSQKNKLCVLLYVVLSSFMLLTICGNLLVIISIIYFRYLHTPTNYLILSMAVADLLIGALIFPLSMTVSLKPCLYIYSLLCNLRSTMDVTMGVSSLLNLCCISVDRYYAVCHPLIYKTKITDCVAMKMGLGSWAVAILCGIFVFLLFFILDECDTSCVFALIAASVVVYYIPTIVLLFMYTKILVVALRQARSIHNTISQNTKSKAVSSTERKATKTLTIVIGIFLICWVPLFLSYSFVPLDSFILYVLLEPFNWFAISNSMLNPFIYAFFYTWFRRAFKMIISGKIFQGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CG41</accession>
    <name>A0A3P9CG41_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aryl hydrocarbon receptor 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_024654499.1">
        <property type="nucleotide sequence ID" value="XM_024798731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CG41"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020831"/>
    <dbReference type="Ensembl" id="ENSMZET00005021515.1">
        <property type="protein sequence ID" value="ENSMZEP00005020831.1"/>
        <property type="gene ID" value="ENSMZEG00005015628.1"/>
    </dbReference>
    <dbReference type="CTD" id="554265"/>
    <dbReference type="GeneTree" id="ENSGT00940000154486"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000035">
        <property type="entry name" value="Aryl hydrocarbon receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000019">
        <property type="entry name" value="Aryl hydrocarbon receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000041">
        <property type="entry name" value="aryl hydrocarbon receptor repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF18">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR 1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="10">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="599"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="794" mass="88191" checksum="C270DC75820BE921" modified="2019-02-13" version="1">MYAARKRRKPAQKGVKPPPIEGAKSNPSKRHRDRLNSELDQLASLLPFPEDVISSLDKLSILRLSVSYLRTKSFFSVALKNRLSSGTNRSSDHNNASKTTRATEIQIPEGELLLQALNGFVLVVTAEGIIFFCSHTIQDYLGFHQTDVMHQSVFELIHTDDQQEFKRNLHWALNPPVSLEPPTDPPDGKSVSTSSCLVSYNPEQLPPENSSFLERSFVCRFRCLLDNSFGFLALNIQGRLKFLHGQSRQQCNSDRTTPPQLALFAIATPLQPPAILEIRTRNMIFRTKHKLDFTPMACDAKGKIVLGYTEAELRVRGSGYQFIHAADMLYCAENHVRMIKTGESGLTVFRLLTKDNRWKWVQANARLIYKNGKPDYIIATQRPLADEEGGEHLRKRSMHLPFTFATGEALLYQTGYPLHGFSDPLQGKARGSKSKKSKGEKGSSDELDPKSLLGALMSQDESVYVCQPDTEPKVSYHSTLFSEQQSRADGLGALFSGDSWYVVSSEESPGERNGKTSSFDPLLTTLDSLSLDGEETCSNSELFSALENLGLNAEDLERLLLDERMMHVELDPDHIPTLSDLLTNNEILSYIHDSLEGASERQEQVNTGRFGSSNHQSNSDSAQSVSQQVCLTAGPVTGGPDSHWVVRTGNHHNRHHTNHNKATELDSKHANAPQWQLQQEQLSAPLQYLQEVCQSLVSTVQPYQLLGHHKHEQTEELEQLLVLTQPPHSVPSLETYGVFAATQDSTHSKLENGCLLGAASTAYVRTCLMSNGNAVATGDIPVPCPDELPALQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGL3</accession>
    <name>A0A3P9CGL3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGL3"/>
    <dbReference type="Ensembl" id="ENSMZET00005021989.1">
        <property type="protein sequence ID" value="ENSMZEP00005021287.1"/>
        <property type="gene ID" value="ENSMZEG00005015949.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166826"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11496">
        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF249">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 6 MEMBER 22, TANDEM DUPLICATE 2 ISOFORM X2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
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            <begin position="137"/>
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        </location>
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    <sequence length="600" mass="68095" checksum="00F57EDBD28F8270" modified="2019-02-13" version="1">HRNNLLGHTQPKAPEREQWANKLEFILAVAGHIIGLGNVWRFPYLCYKNGGGVFFIPYVLFLFTCGIPLFFLETSLGQYTSQGGITCWRKICPLFEGLGYGSQVVVLYTGMYYIIILAWAFLYLFSSFRAELPWASCHNSWNTNGCFEHSHNQTFPVDPNGKSVSSVVEFWERRILGLSDGIDNIGNIRWDLALCLLLAWVLCYFCIWNGVKTTGKVVYFTATFPFVMLVVLLVRGLTLPGAKDGIMFYLYPDPSRLTDPEVWMDAGSQIFYSYGVCTGVLTSLGSYNKYNNNCYRDCVYLCLLNSLTSFVAGFAIFSVLGFMAKEQGLDISMVAESGPGLAFIAYPRAVALMPVPQLWAIFFFIMVIFLGLDSEFVYQEALVTTISDMYPSFFQNNCHRKLLLLGINVGSFLVGLLMVTEGGLYIFQLFDYYACSGMTLLLFAILQSVCIGWVYGGDRQYDNTKDMIGYRPWPFMKYCWQYFTPAICTCTFLFSLIKYTPLKFNNTYEYPWWGYAIGGLFTLSSTLMVPLWMLYAVCITPGTLRQRLKLLCTPAKDLPSATSKKASNYEAFQTFTDLHTLRKTKSPDDRDEQIQGSYII</sequence>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
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                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
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                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
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                <person name="Gaffney L."/>
                <person name="Galibert F."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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                <person name="Streelman J.T."/>
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                <person name="Swofford R."/>
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                <person name="Venkatesh B."/>
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            <authorList>
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            <authorList>
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        <property type="entry name" value="EXPORTED REPETITIVE PROTEIN"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="235" mass="25823" checksum="8DF4802D00179814" modified="2019-02-13" version="1">MCLLVLFCVCQGPRCPLVLRLFSLGGPRSPSSLLFRRLGGPRSPSGLLFRRLGGLRPEACFTTYGCSAASCSTTTCSLSCLHPRLVQPSCLHPRLVQPSCQHPRLVQPSCLHPRLVQPSCLHPRLVQPSCLPPRLVQPSCLHPRLAQPSCLHPRLVQPSCLPPRLVQPSCLHPRLAQPSCLPPRLVQPLCLHHRLQQLLCISVHVSCVCVCVRIPCSAERKSPVKRRSTVSSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CIN0</accession>
    <name>A0A3P9CIN0_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
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            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004571879.1">
        <property type="nucleotide sequence ID" value="XM_004571822.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CIN0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022153"/>
    <dbReference type="Ensembl" id="ENSMZET00005022895.1">
        <property type="protein sequence ID" value="ENSMZEP00005022153.1"/>
        <property type="gene ID" value="ENSMZEG00005016613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463620"/>
    <dbReference type="KEGG" id="mze:101463620"/>
    <dbReference type="GeneTree" id="ENSGT00940000165402"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="76"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="595" mass="66164" checksum="6D78F65EB0F5DDE1" modified="2019-02-13" version="1">MNEDAFEVPERTEYRYLVQEEDEEEVQYVRHRHYISPFLVLSKRCIFLICLGVLALLALAAYLGYIAQTLPPGLAQVSTDCGDFRGRYKNGAYSFKGMSYAAPPVGGLRWAPPVEPVCKSGVIDAGHFRSMCPQVRPLSSTGKVMGQEDCLFINVWTPTLQPDAKLPVMVWIHGGYLHMLSGGEKGYSPTEKLAADTKVVYVSFNYRLNAFGFLALQMLREGSPRNTSGNYGFLDQIAALKWVQKNIRVFGGDPGKVTIFGQSSGGTSVWTLMMSPLAKGLFHAAVDMSGSYIYNATLEQAEVDNLAFLNKTGCGDLACLRRLSIGQVLQAIPWQEYPSWAADEMTDLPTKGKSIGPVAVVDGYVLKAPPFELWEKKGEHSDVPFLVGTTEQEADFAPPSTNISEWTWGDYTWFVTAKLKSFGDGLVKEALRLYPSSAWCPTKDRCPERSYTTMVSDIRVTCPNNDLAQRAAAALKSPVYRYVVRHTPSGPVNTSSDLLPFPSRFSFHCLDAVAFFGGLEFILGKPLSDKDRRFQDLITRNLVSFAKTGKVETKWSEYPSAIAFLSDILEVDSNYTSPQCDLWRKNGLYAYAWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKU1</accession>
    <name>A0A3P9CKU1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012780015.1">
        <property type="nucleotide sequence ID" value="XM_012924561.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKU1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022943"/>
    <dbReference type="Ensembl" id="ENSMZET00005023696.1">
        <property type="protein sequence ID" value="ENSMZEP00005022943.1"/>
        <property type="gene ID" value="ENSMZEG00005017179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464199"/>
    <dbReference type="KEGG" id="mze:101464199"/>
    <dbReference type="CTD" id="558648"/>
    <dbReference type="GeneTree" id="ENSGT00390000005508"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000658">
        <property type="entry name" value="PRK00029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153:SF15">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12153">
        <property type="entry name" value="SELENOPROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="637"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="689" mass="77028" checksum="D098DD0E1567CCA7" modified="2019-02-13" version="1">MAYLGPRLGPSRVFLSGVSALRLVSTAGMDDMGLAMSRSSLERLEFDNVALKKLPLDPSEEQGVRQVKGACFSRVTPQPLTKPRFVAVSHQAQALLGLDGEEVVNDPLGPEYLSGSKVMPGSEPAAHCYCGHQYGQFAGQLGDGAACYLGEVKVPSGQDPELLRENPSGRWEIQVKGAGLTPYSRQADGRKVLRSSIREFLCSEAMFFLGVPTTRAGSVVTSDSRVIRDVYYNGHARHERCSVVLRIAPTFIRFGSFEIFKPADEFTGRQGPSYGRDEIRGQMMDYVIEMFYPEIQQNYPDRVERNVAFFREVVLRTARLVAQWQCVGFCHGVLNTDNMSILGLTLDYGPYGFMDRFDPDFICNASDNSGRYSYQAQPAICRWNLVKLAEALAPELPPDRAEAVLEEYLDLYNRFYLENMRKKLGLLKKEDPEDEILITKLLQTMHNTGADFTNTFRSLSLISCPTEENSEGEEDSVKKATDLLIEQCASLEELKAANKPTMDPRELAVLLSMAQSNPALFQMISDRATIARQLERLSKLKDLMETTQEELKTKQAEDWTSWITQYRKRLARELEGQSDVQAVQEERVRVMDSTNPRVILRNYIAQNAIEAAENGDFSEVQRVLKVLEKPFSSQPGLELPAWVGGGGTSAEGERDEGEEQQQEAATAMPRNPVPYDSKPPAWANEICVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CL54</accession>
    <name>A0A3P9CL54_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 37</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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        <subcellularLocation>
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    <dbReference type="STRING" id="106582.ENSMZEP00005022779"/>
    <dbReference type="Ensembl" id="ENSMZET00005023530.1">
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        <property type="gene ID" value="ENSMZEG00005017050.1"/>
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    <dbReference type="KEGG" id="mze:101470374"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
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    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
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        </location>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLN1</accession>
    <name>A0A3P9CLN1_9CICH</name>
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        <recommendedName>
            <fullName evidence="5">hyaluronoglucosaminidase</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEMIP family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="5"/>
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        <property type="nucleotide sequence ID" value="XM_014411347.2"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005022944"/>
    <dbReference type="Ensembl" id="ENSMZET00005023697.1">
        <property type="protein sequence ID" value="ENSMZEP00005022944.1"/>
        <property type="gene ID" value="ENSMZEG00005017171.1"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd13938">
        <property type="entry name" value="PANDER_like_TMEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052252">
        <property type="entry name" value="CEMIP/CEMIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055401">
        <property type="entry name" value="CEMIP_beta-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055400">
        <property type="entry name" value="CEMIP_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019316">
        <property type="entry name" value="G8_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039473">
        <property type="entry name" value="TMEM2_PANDER-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025155">
        <property type="entry name" value="WxxW_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535:SF15">
        <property type="entry name" value="CELL MIGRATION-INDUCING AND HYALURONAN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15535">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24606">
        <property type="entry name" value="CEMIP_beta-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24605">
        <property type="entry name" value="CEMIP_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10162">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13330">
        <property type="entry name" value="Mucin2_WxxW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01225">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51484">
        <property type="entry name" value="G8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017947592" description="hyaluronoglucosaminidase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="domain" description="G8" evidence="17">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1348" mass="150927" checksum="CD85A01EF340591E" modified="2019-02-13" version="1">MKTCVVFLAALLLPTIHAVCPDKEPGLQPWMPGHSEDHRVTISNNSTVLLTTSATVHSIEILSGGKLVIADTNRPILLRTKHILIGNKGELHIGSPDCPYKGNLTILLFGRLDDSDEEHSYFGRKYIGVGSGGTLEIHGERKLSWTFLNKTLHPRESSQNNYLFQRSWGNRGIIIHVIDPKTGEVLHDDRFDTYRSKNESYRLAKYVNGIKPGLILAMMVNDEGSNNLEDSAKKSISRLGSKHIGSLGFRHPWTFIVTKGDVSSVVEDTAVYQGTKASSEARSAQVFQSSFGEHFTVTASSQWVQEAEWSNWFDRDDERGSGDWEKLSDLHKAYPDRLCSSPLDIQAETHDGIPSNQTGDVIHKKHKDYGFVCLNKDQTHGLCHNYRVRFLCGKLVHPQASVSIDMMSNSSILELADHPAGWGPGDRVVVASTDYSMHQAEEFTLLPCPTCASNQLKVRGKAKFIHMGEEVDGVDMRAEVGLLSRNILLRGEMEPSCYGNEACKFFNFDTFGGHLKVEHGFRAVHISGMELQHMGQQTMGHYPVHFHMNGDVDERGGYDPPTSVSDLSIHHSFSRCVTIHGSNGLMVKDVVGYDTLGHCFFTEDGPEERNTFEHCLGLMVRAGTLLPSDRDSKMCRDITDGAYPGYVPNPRQDCSATSTFWIANPNNNLINCAAAGSEETGFWFLFHHMATGPSNGSYSPGYTEHTPMGQFTNNRAHSNFRAGMILDNGVKTTQANNKDKRPFLSLIGARYGPHQDSDPFKPRVPALIHHFTAYKNQYHGAWLRGGDVWLDDCQFADNGIGLTLASGGTFPEDDGSHQQVKNSLFVGESDNRGMPFPDKRIWGPGGPDLTDRTLPRGIDFPIRGMQIYDGPINVQNCTFRKYTALNGRHTSAFGFRLNNSWQSCPNNNVTNITFDHVPITSRVFFGEPGPWFSKMQMDGDKTTIFHDIDGSVSEYPGAFLVKEDNWLLRHPDCIDVPDWKGAICSGHYAQIYVQTRNPANLNMQIVRDEYPDRPLTLEGALDKRKVYQQFQPVVTLAKGYTIHWDQAAPAEVTIWLINFNKNDWINVGLCYPQGTTFTILSDIHNRLTKQTRKTGVFVRTTHKEKINHLHLARGYFYWEEDTGLLFLKVKAHNHRETFAFCSVKGCERVKITAIVPKGSPPSNCLAKAYPKHAELPIVDVPMPRKIPTARLHSSEHFLEIKLESYNTRHFHIKKDVAFTEVNGKTLHQPEDGVHLTVIDGHDGKVVDTKGFRNSILQGIPAEIDNYISGLRDNSIVLMTSKGRLVTRGSWTKVLGKLGAEKSVRLKDKLAFVGFKGSFHPDWVYLEADSEQAKIHQVLPVPVIHKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMB4</accession>
    <name>A0A3P9CMB4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L1 transposable element RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMB4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022961"/>
    <dbReference type="Ensembl" id="ENSMZET00005023716.1">
        <property type="protein sequence ID" value="ENSMZEP00005022961.1"/>
        <property type="gene ID" value="ENSMZEG00005017192.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177124"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35078" checksum="4B727C5234DE1D4A" modified="2019-02-13" version="1">SQRVSKKNPSPSLQTATTPSSEPSSPAKPPTCQANPDIEALKVELLASLRKDIADIFKKELQDTLGDAFSTIKFDLQAVKTQLAIDKAANDATMSELKGTVKEMEHALTVCSDDIAEMKNTIKGLTAHVAKLESKCEDLESRSRRNNVRIVGVPEGPDTCTTAAVASLLKEAFDLGKEPLLDRSHRTLQPAPKPGDRPRAIVCRFHYHTDCVDILRRARERRQIKVRDRTISVFPDYTARVARARAAFNTVRQQLRGIDGVRYGLLHPALLRITYKGVEKDFVSAEEARDYVKTLISGWFLTHSKSGFSLDVTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMS9</accession>
    <name>A0A3P9CMS9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">deoxyguanosine kinase</fullName>
            <ecNumber evidence="7">2.7.1.113</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyguanosine + ATP = dGMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19201"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57673"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.113"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.113" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMS9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023387"/>
    <dbReference type="Ensembl" id="ENSMZET00005024153.1">
        <property type="protein sequence ID" value="ENSMZEP00005023387.1"/>
        <property type="gene ID" value="ENSMZEG00005017502.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159627"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004138">
        <property type="term" value="F:deoxyguanosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000461">
        <property type="entry name" value="Deoxycytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF8">
        <property type="entry name" value="DEOXYGUANOSINE KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="12">
        <location>
            <begin position="30"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="34"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039043"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="260" mass="29999" checksum="25C4F4E1871CD566" modified="2019-02-13" version="1">MANKRGSLTLFSSRCLSGSAADAKARVRRVSIEGNIAVGKSTFAKLLQSACADWEVVAEPVSKWQNIESETSKTTVSNLLQMMYQDPQRWSYTFQTYSCMSRLRTQLQPPPARLLQSKGTPVQVYERSVYSDRYIFALNMFELGCINTTEWAVYQDWHSLLVEQFGHQVELEGIIYLSAPPEKCMERLQRRGRAEEEGVKLDYLDKLHSQHERWLVEKTTEIHFEKLKQIPVLKLDASVEFKSDPEVQEQFITKVCLNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CN21</accession>
    <name>A0A3P9CN21_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005023201"/>
    <dbReference type="Ensembl" id="ENSMZET00005023962.1">
        <property type="protein sequence ID" value="ENSMZEP00005023201.1"/>
        <property type="gene ID" value="ENSMZEG00005017379.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16388" checksum="5BEB2678BBD9C0F1" modified="2019-02-13" version="1">MLHPEREVWSKLIKFTFEMNSILQKKLVDNDTCWKCHEEAGTLVHMLYTCRKNDYLWDGIINLVNDIFKLNRSKSPAVCVLGLLPDNSILSRRQRLWMRLAFITGCRIILRHWKSSSPCSLREWTEQMSKMALYERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CN45</accession>
    <name>A0A3P9CN45_9CICH</name>
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        <recommendedName>
            <fullName evidence="6">GDP-D-glucose phosphorylase 1</fullName>
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        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30387"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:62230"/>
            <dbReference type="EC" id="2.7.7.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GDPGP1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.78" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004563487.1">
        <property type="nucleotide sequence ID" value="XM_004563430.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004563488.1">
        <property type="nucleotide sequence ID" value="XM_004563431.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CN45"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023773"/>
    <dbReference type="Ensembl" id="ENSMZET00005024553.1">
        <property type="protein sequence ID" value="ENSMZEP00005023773.1"/>
        <property type="gene ID" value="ENSMZEG00005017782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485114"/>
    <dbReference type="KEGG" id="mze:101485114"/>
    <dbReference type="CTD" id="390637"/>
    <dbReference type="GeneTree" id="ENSGT00390000016718"/>
    <dbReference type="OrthoDB" id="417175at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080048">
        <property type="term" value="F:GDP-D-glucose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026506">
        <property type="entry name" value="GDPGP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058865">
        <property type="entry name" value="GDPGP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058866">
        <property type="entry name" value="GDPGP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20884">
        <property type="entry name" value="GDP-D-GLUCOSE PHOSPHORYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20884:SF8">
        <property type="entry name" value="GDP-D-GLUCOSE PHOSPHORYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26216">
        <property type="entry name" value="GDPGP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26217">
        <property type="entry name" value="GDPGP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDPGP1-like N-terminal" evidence="14">
        <location>
            <begin position="32"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GDPGP1-like C-terminal" evidence="13">
        <location>
            <begin position="224"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF26216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF26217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="365" mass="41329" checksum="A4E15A439D37107B" modified="2019-02-13" version="1">MSIQFVYSHQHFVTDVYRISGNNSAKNSASTKFDTAIQGGWADRMARGIFRYHLGDLKTRVLLGSHGYVAQLNIQRGIERRKPQEIMSIKQEFNAKQFNFNKIKHDEIIFEMIKDKKGGSPLTNNAECPQPQKMVVLVNVSPLEFGHCLFVPDPAHCRPQILTKFAIHVGIEAVLLSSDPGFRVGFNSLGAFASVNHLHLHGYYLDHPLKIESKPVKPLCPEKGFYRILDFPAGFLFYAESEEVEKVAQTICEVTDFLVNDNIAHNLFLTRGSPPCVQTQGEKDFCSRKGVRVAVWPRISCFGAKEESAFNVALCELAGHLPFKSKKDFERMTEKDVVDVIQSYLLPEDEFHQLEQQLTEHLLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNL5</accession>
    <name>A0A3P9CNL5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CNL5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023925"/>
    <dbReference type="Ensembl" id="ENSMZET00005024710.1">
        <property type="protein sequence ID" value="ENSMZEP00005023925.1"/>
        <property type="gene ID" value="ENSMZEG00005017907.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161373"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF3">
        <property type="entry name" value="PROGRAMMED CELL DEATH 1 LIGAND 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="139"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="288" mass="31952" checksum="A55DC6F7CBE97985" modified="2019-02-13" version="1">LNGTFLQIHLHAEQSMYTSEFGESVVMGCKFNPKPSYPHPDLNVTWHWINSDSVQDVIRLDNGVPRSESPKYRGRVQLLTEELAEGWAKLKMSSLRISDAGKYQCVVHSADGADYKTIALSVEASYKSVTKHIERAATGDEVLITCQSEGYPKSTVEWQNGNLKTLNPNTTAESTPDQIFRITSQIKVSSSEKNNYTCKFTKDGSSATIYIPDEIPLSPAKSDAVIIILCIAVIVAFVSVGVVTYRRRKGNQSVPQFSTDRNAYISCVVLQTEMLVSNKMMGNNLVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNQ1</accession>
    <name>A0A3P9CNQ1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hairy-related 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004562013.1">
        <property type="nucleotide sequence ID" value="XM_004561956.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CNQ1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023712"/>
    <dbReference type="Ensembl" id="ENSMZET00005024489.1">
        <property type="protein sequence ID" value="ENSMZEP00005023712.1"/>
        <property type="gene ID" value="ENSMZEG00005017735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479362"/>
    <dbReference type="KEGG" id="mze:101479362"/>
    <dbReference type="CTD" id="30288"/>
    <dbReference type="GeneTree" id="ENSGT00940000159619"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904888">
        <property type="term" value="P:cranial skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001757">
        <property type="term" value="P:somite specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021794">
        <property type="term" value="P:thalamus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11459">
        <property type="entry name" value="bHLH-O_HES1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="9">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="277" mass="29866" checksum="065E63F76B39E9FB" modified="2019-02-13" version="1">MPADMMEKTSSSPVAATPASMNTTPDKPKTASEHRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALNTDPTVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMNYPSQHQHQHQLPSTAGPTHPSFGQSMVQIPNSSPQVLPMNPVSCKGGSSPASLPSDATKVYGGFQIVPATDGQFAFLIPNAAFAPNGPVIPVYANNVSTPVPVPAAVSPGAPSGNTDSVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPT5</accession>
    <name>A0A3P9CPT5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538301.1">
        <property type="nucleotide sequence ID" value="XM_004538244.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPT5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023801"/>
    <dbReference type="Ensembl" id="ENSMZET00005024582.1">
        <property type="protein sequence ID" value="ENSMZEP00005023801.1"/>
        <property type="gene ID" value="ENSMZEG00005017804.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476171"/>
    <dbReference type="KEGG" id="mze:101476171"/>
    <dbReference type="CTD" id="51184"/>
    <dbReference type="GeneTree" id="ENSGT00950000183172"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="285" mass="32720" checksum="A826EB20F01559F9" modified="2019-02-13" version="1">MPRYAQLVMGPAGSGKSTYCSTMVQHSETLNRSVQVVNLDPAAEHFEYPVMADIRELIQVDDVMEDESLRFGPNGGLVFCMEYFANNFDWLEESLGHVEDDYILFDCPGQIELYTHLPVMKQLVEQLQQWEFRVCGVFLVDSQFMVESFKFISGVMAALSAMVSLEIPQVNIMTKMDLLSPKAKKEIEKYLDPDMYSMMEDGSNTIRSKKFKKLTKAICGLIDDYSIVRFLPFDRTDEEGINIVLQHIDFSIQYGEDLEFKEPKEVEEQPANLNYDDIFQDKANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQN7</accession>
    <name>A0A3P9CQN7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the POU transcription factor family. Class-3 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQN7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024663"/>
    <dbReference type="Ensembl" id="ENSMZET00005025469.1">
        <property type="protein sequence ID" value="ENSMZEP00005024663.1"/>
        <property type="gene ID" value="ENSMZEG00005018423.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160115"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000972">
        <property type="entry name" value="TF_octamer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF46">
        <property type="entry name" value="POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00029">
        <property type="entry name" value="OCTAMER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="14">
        <location>
            <begin position="321"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="420"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="422"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="519"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="655"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="655"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="699" mass="74125" checksum="97D4A45E3ABC3ACD" modified="2019-02-13" version="1">MFVPLPVPFVFQRATPDLNAWRLKSPLALRSNSIRMSKPGEAEKVGADSPLEGTDSERNGPESNHQTQSMKACPFPLSPNLSSTKNKMEECADMSPALPSSHGPTPSQTALQHTQLMLTGSQLAGLTALLPAQQQLLLQQAQAQLLAAAVQQSNAAHAAHAAHAAAQANQQAQAAAAANQQAQQQQQQQQQQQQQVGQQTQSQSQGQNTQEQSAQSVPVPPPPSQLTLSQPIQLTAQDIQQLLQLQQLVLVPGHPLPSPAQFLLPQAQQSQQLLSTPNLIPLPQQNQGSLLSAPTRMGLQAQVEVSGGGVTTVPSVTSHPEDPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDATMSIDSTLPSPSSLSSPSLGFDGVPSRRRKKRTSIETNVRVALERSFMTNQKPTSEEILLIAEQLNMEKEVIRVWFCNRRQKEKRINPSSATPPLPNQPPTAPPAHKPPCYSPHMTTMSSVCPLTSSLTSTHPSLSLTHTPLSSTPSPATPPPPPIPPRSTASPATPSHSTLNLNTNTVMGVNTGMNQALLGNNPLATIQSGGHLPLSTLEGGSKVMLGASGGQGGGIPSSLFLNHPALLHIGQNPNAGLVSTTVAKLSQSSPFPSASSISPTPCSPSPCSSPASSCSSSEMAHSPPSLGGAKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CR85</accession>
    <name>A0A3P9CR85_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zgc:153704</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CR85"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024589"/>
    <dbReference type="Ensembl" id="ENSMZET00005025393.1">
        <property type="protein sequence ID" value="ENSMZEP00005024589.1"/>
        <property type="gene ID" value="ENSMZEG00005018384.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271921"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
        <property type="term" value="F:small molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002345">
        <property type="entry name" value="Lipocalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11430:SF133">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIPOCALIN"/>
    </dbReference>
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        <property type="entry name" value="PGNDSYNTHASE"/>
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        <property type="entry name" value="Lipocalins"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018000346" evidence="2">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="34"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="182" mass="20279" checksum="5132B6A1CAF9252A" modified="2019-02-13" version="1">AMHLLLTLLGAVLSSLMVSSEVQPQADFNVQAMAGKWYLIGIATDAQWFVSHRASMKMGTAMITPTADGDLEMSYSSLSPNGSCWRMNNLAKKTEIPGKFTYTSRRWGYLSDLRMVDVKYDEYALIHSIKTKGKESYVVNKLYGRGVDLSAEVQEKFIQFSLQSSIQPENIVILPKNQCPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRE8</accession>
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        <submittedName>
            <fullName evidence="14">C-C motif chemokine receptor 9</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
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    <dbReference type="RefSeq" id="XP_004551993.1">
        <property type="nucleotide sequence ID" value="XM_004551936.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9CRE8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024915"/>
    <dbReference type="Ensembl" id="ENSMZET00005025725.1">
        <property type="protein sequence ID" value="ENSMZEP00005024915.1"/>
        <property type="gene ID" value="ENSMZEG00005018603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483872"/>
    <dbReference type="KEGG" id="mze:101483872"/>
    <dbReference type="GeneTree" id="ENSGT01030000234667"/>
    <dbReference type="OrthoDB" id="9942559at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="C-C chemokine receptor type 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000355">
        <property type="entry name" value="Chemokine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF664">
        <property type="entry name" value="C-C CHEMOKINE RECEPTOR TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00657">
        <property type="entry name" value="CCCHEMOKINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="55"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="359" mass="41031" checksum="E5E9B7AA5C53660C" modified="2019-02-13" version="1">MEDFSDFNETTYSPTEDYSLPTDESGMCDRTWVREFRGQYEPPLFWIIFILGAVGNLLVVWIYTTVRNRLKTMTDVYLLNLAVADLLFLCMLPFWAVDAIKGWDFGITLCKIVSAVYKINFFSSMFLLTCISVDRYIAIVQVIKAQNLKKKRLFYSKLACLGVWFVSALLTLPEFIFAEVKISQEMQFCTMVYWNNVNNHTKILVLSLQICMGFCIPLLVMFFCYSVIIRTLMQAKSFEKHKALRVILAVVFVFVLSQLPYNSLLIVEARQATNMTYTDCDTVINFDIAGQVAKSLAYTHACLNPFLYVFIGVRFRQDLQRMVRTCIGGMSKGGLSKTQAVPKRPSLMSDTDTTPALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CS05</accession>
    <name>A0A3P9CS05_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acyl-CoA-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004572007.1">
        <property type="nucleotide sequence ID" value="XM_004571950.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CS05"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024849"/>
    <dbReference type="Ensembl" id="ENSMZET00005025658.1">
        <property type="protein sequence ID" value="ENSMZEP00005024849.1"/>
        <property type="gene ID" value="ENSMZEG00005018559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472222"/>
    <dbReference type="KEGG" id="mze:101472222"/>
    <dbReference type="CTD" id="1622"/>
    <dbReference type="GeneTree" id="ENSGT00940000154846"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00435">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF54">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ACB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="89" mass="10152" checksum="782945764F1270DB" modified="2019-02-13" version="1">MAELQTKFDEAAAEVKQLKAKPTDEEMLQIYSLFKQATVGDVNTARPGMFDFTGKAKWDAWEKQKGKSNENAMNEYISLVEELKQKYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSA6</accession>
    <name>A0A3P9CSA6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitofusin 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004570985.1">
        <property type="nucleotide sequence ID" value="XM_004570928.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023009509.1">
        <property type="nucleotide sequence ID" value="XM_023153741.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSA6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024902"/>
    <dbReference type="Ensembl" id="ENSMZET00005025712.1">
        <property type="protein sequence ID" value="ENSMZEP00005024902.1"/>
        <property type="gene ID" value="ENSMZEG00005018589.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476877"/>
    <dbReference type="KEGG" id="mze:101476877"/>
    <dbReference type="CTD" id="9927"/>
    <dbReference type="GeneTree" id="ENSGT00390000013727"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019896">
        <property type="term" value="P:axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09912">
        <property type="entry name" value="DLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000012">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000214">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF1">
        <property type="entry name" value="MITOFUSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="94"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="709"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="759" mass="85920" checksum="A4715430AC2F98D4" modified="2019-02-13" version="1">MSLVFPRLSTNPFHSKKEKRIMAEVNASPLKHFVTAKKKINGIFEQLGAYIKESASFLEEAYKSEELDPVATEEQVQEVQGYLAKVTGIGEVLARRHMKVVFFGRTSNGKSSVINAMLCDKVLPSGIGHTTNCFLRVEGTDGNEAFILTGGSEERKNIKTVNQLAHALHQDEDLDAGSLVCVMWPKAKCALLRDDLVLVDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKSFFHKVNERLSSPNIFILNNRWDASASEPEYMEEVRGQHMDRCTNFLVDELGVVDRAQAGDRIFFVSAKEVLQARVQKAQGMPEAGGALAEGFQARMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQISEALRHIMDSVYIAAQEQRVYCLETKEDRQDRLEFIDKQLDLLTMDCKSKIKKITEEVERQVSNAMAEEIRKLHVLVDDFHMDFHPSPVVLKVYKNELHRHIEEGLGKNMSERCSTSISSALQTTQNDMIEGLKPLLPSAVREQVDKLVPRSQCFSLSYDLACDKLCSDFQEDISFHFSLGWTMLVNRFLGPKNTRRVLMGYNDQVPRPMALTPVSTSMPPFPQSAMTQEELMVSMVTGLASLTSRTSMGVLVVGGVIWKAVGWRLIALSLGLYGLLYIYERLTWTTKAKERAFKRQFVDYASEKLQLIVSYTGSNCSHQVQQELAGVFAQLCQQVDITRQNLEDDITDMNSKIELLDSLQSKAKLLRNKAGWLDSELNMFTQQYLHHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CT93</accession>
    <name>A0A3P9CT93_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Prolactin</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the somatotropin/prolactin family.</text>
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    <dbReference type="RefSeq" id="XP_004570369.1">
        <property type="nucleotide sequence ID" value="XM_004570312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CT93"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025242"/>
    <dbReference type="Ensembl" id="ENSMZET00005026064.1">
        <property type="protein sequence ID" value="ENSMZEP00005025242.1"/>
        <property type="gene ID" value="ENSMZEG00005018843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479120"/>
    <dbReference type="KEGG" id="mze:101479120"/>
    <dbReference type="GeneTree" id="ENSGT00950000182818"/>
    <dbReference type="OrthoDB" id="9946219at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031667">
        <property type="term" value="P:response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001400">
        <property type="entry name" value="Somatotropin/Prolactin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018116">
        <property type="entry name" value="Somatotropin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417:SF5">
        <property type="entry name" value="PROLACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11417">
        <property type="entry name" value="SOMATOTROPIN,PROLACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00103">
        <property type="entry name" value="Hormone_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00836">
        <property type="entry name" value="SOMATOTROPIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00266">
        <property type="entry name" value="SOMATOTROPIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00338">
        <property type="entry name" value="SOMATOTROPIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0372">Hormone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018216527" evidence="8">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="201" mass="22315" checksum="61027809E021D826" modified="2019-02-13" version="1">MAQRRIRGGKLVMVLCVVAMCRAVPINDLIYRASQQSDQLHALSTMLTQELQGSEVFPIDRVHACHTSSLQTPTDKEQALQVSESDLLSLARSLLQAWSDPLVVLSSSTNVLPYSAQSTLSKTIQKMQEHSKDLKDGLDILSSKMGPAAQTITSLPFIETNEIGQDKITKLLSCFRRDSHKIDSFLKVLRCRAANMQPQMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CV28</accession>
    <name>A0A3P9CV28_9CICH</name>
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        <submittedName>
            <fullName evidence="9">Ring finger protein 17</fullName>
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    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004573086.1">
        <property type="nucleotide sequence ID" value="XM_004573029.5"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005025681"/>
    <dbReference type="Ensembl" id="ENSMZET00005026514.1">
        <property type="protein sequence ID" value="ENSMZEP00005025681.1"/>
        <property type="gene ID" value="ENSMZEG00005019166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469824"/>
    <dbReference type="KEGG" id="mze:101469824"/>
    <dbReference type="CTD" id="56163"/>
    <dbReference type="GeneTree" id="ENSGT00940000157559"/>
    <dbReference type="OrthoDB" id="5800423at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="8">
        <location>
            <begin position="713"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="8">
        <location>
            <begin position="955"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="8">
        <location>
            <begin position="1219"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="8">
        <location>
            <begin position="1451"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="123"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1593" mass="177823" checksum="1B43C2200F8D2916" modified="2019-02-13" version="1">MDRGENHSAAICKLCGEAFTLPEDDIPGNLPRVLLCGHIYCTFCLQSLECDSVIRCPECEVVSTLPEGQVYGLQEDSRIIGLIYTTKMNKMKRCDKSKNRKKNKASPSTDTHVSSDMEQPADIEKIQKTVDEALAQAAETLAQLVHIHETLTTGLEEQVKREVARLEMEIKQAADKALHAVQNWKDSQMSQLTELETKFSSSQAAVRHIQERIKALEIAMQMARKVRCVPFLEQYCILNKVLETLQAPVDDQLIDMKCITVGTGMSCVFQLECLNGNLALSLKMEVSDPKDLAQSPPKSYQPGRFGRKSHLKRPDGRNSRCIPRSDKIHTPPKQRQQSPRANSPSSRGSSPSPRSRCRFNLSRHSSASDLGSPDVIIEDFLDEGQALPPTGPELASDKLRINRRRKHQFSATKRSAVTQWVVVTHIVNPSQFYVQSVAERRESEILSDKINQLCSGDGCSFTAKDTVETESLICVKWNEGHWCRARVVEVLQKGSLEPVKTCAVTQLASIRVFFLDHGLTKSITINSEDEATEASLSAVNNQLRKVGRAVKNDLAHFAPMVIRCSLKDLVPYDVTKGWSKEAQVEFRNVVGSAAVEMRPLGQDRESLLVDLRKAPVEQFSSSVFISIREYLVFIEVARFYSPVTLSRKPLLYYPPVYPKINSEISAMVCHINNPANFYINLVDNMEFMLLSAKLQEFYNDLALLEEDKLSIYCPVIGQSCVARLDDKLWYRAQVTGHPGGRKVEVQFVDLGNRKILSVSDLRKIKDEFFALPARAINCCLSDVIPVDGESWTDACTNRFISLANQKLVTIIATGQGPKSEPLPVKLFQGEVNEPLTSIAELLVKEELACFKESLNPKNAWPSGDDSAIWDPPLEVGLATGLVDVPDQIISGNQKEDPIEPQLKLPAQLKDLKVRVCHVNSPSSFYVRFAQYDSQLKRICELVKQECARIEPQDVEWKADMYCAALFNGVWERAQICSDVTSSDSAEVRLCDHGKMMKIDVSNLRPLPSSLIGSLALECTLNDIRPTGGRSTWTNTACDSFSYYLTGASAVMTIKELTDERPVPVTLFCSNRMGEFISIADFLVSEGLALRQRKPSNINVQQPKDMDPPSTVREVQNKSETETSSPSVPVISFPFQSSTVSGHMPPKPAPRSIMTAEKVKTSLYQPPELPCLGHIQISISAVGEDGLIYVRTQNAGYQLEQLKERIQQSMKALPRQKPYTWKSVLGCAVIGPDMLWYRGQLLEVLGGHVKVQYVDYGLVENIPVVHVYPILLCDDVPQLCMICQLLGINPVGGKWQQDAVALMREVLLNRSVDMNVVELPADPRGPVTVELFIDGLSLSRILCQHEHASMDRTVSPDKHLTVMPTAPVFDVWDINTEGLRDPEELMLGSFTYPNLQQEGEHFKVVVKHMCTPNELFLWPLEGTADVKVNGESLDEALTRINRNIDTLPRLSNFPEGGPCLAEYSDGKYYRARLMKFISAEPVTLLVQHVDFGSDDTLPTSKLRQMPAELLEFPCRALKVKVAGFKAPSVTREENVLPYSPKWSMKAAMEMIDLLHKNITASVVAQEPELTVLLYSEDGELVHLPLVTKGLAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CV67</accession>
    <name>A0A3P9CV67_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Si:dkey-175g6.2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CV67"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025721"/>
    <dbReference type="Ensembl" id="ENSMZET00005026553.1">
        <property type="protein sequence ID" value="ENSMZEP00005025721.1"/>
        <property type="gene ID" value="ENSMZEG00005019196.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144784"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026128">
        <property type="entry name" value="VGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15159">
        <property type="entry name" value="NEUROSECRETORY PROTEIN VGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15159:SF3">
        <property type="entry name" value="SI:DKEY-175G6.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017997203" evidence="2">
        <location>
            <begin position="30"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="499" mass="55805" checksum="DFA49B6665591F6D" modified="2019-02-13" version="1">MVMTCHHAPSTAHLILLVLLIVIPQLADTAPVWGEAGEGGVEGRTRTDRKEDNLAPFHSPQPQSLSSPDNVSLDWGRGPGQDSQLDKVTDPAQVLAVLLEALDHLGDSEKQASKNRDWEGDRSPELPSAEGSEGGEIRRTEQPQGERGVEAEKEGRGADKAIEQLNVGHLAAAQGDDLKEREGEEGDNTRSEDQGWSVKNVGTDSVREDEKKDEGEGQEEGKYSESFLDEAMPGSTSEGDDPSLQRKIRGYFQNIDLGLQDNEILPPLKGYKAYNTQLARAGKKQHWQENPSRNRPVKGGNFMDDFEDEGEELEEEVEEEEESLSHMEEEARARAEKQEVLRQQEEAERAREEEQRLADIASDMLLQYMGRKQQSYMKPRQKSSMGAAGNTAEDKRSEEILPDEDDLDQQMIDRLIEISSKLHLPADDVIEIISDVEEKKKKRKELQQLPTNSNPVAPRFRPLVPPPLVAPPVYHYTPGPPPPPLPPKQQMRKHLTLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CWL2</accession>
    <name>A0A3P9CWL2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomal protein of 19 kDa</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557237.1">
        <property type="nucleotide sequence ID" value="XM_004557180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CWL2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026728"/>
    <dbReference type="Ensembl" id="ENSMZET00005027585.1">
        <property type="protein sequence ID" value="ENSMZEP00005026728.1"/>
        <property type="gene ID" value="ENSMZEG00005019931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482246"/>
    <dbReference type="KEGG" id="mze:101482246"/>
    <dbReference type="CTD" id="84984"/>
    <dbReference type="GeneTree" id="ENSGT00390000016356"/>
    <dbReference type="OrthoDB" id="2163581at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097712">
        <property type="term" value="P:vesicle targeting, trans-Golgi to periciliary membrane compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029412">
        <property type="entry name" value="CEP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31539">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 19K CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14933">
        <property type="entry name" value="CEP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="158" mass="18731" checksum="BAFA5870A690D3E6" modified="2019-02-13" version="1">MRFAAKRCGVQFSPPSIVLIYEHTETKKVRKRIIPVRNFSKYSDYSMAAERLKNNPRHRDYLEGVSQSQLEKLHIILRDHMQGFSLEHSLSSFCLDPDEDLNKLDDEDLARKKGQMDELFEKNRRRKDDPDFVYDFEVDFTKTTLEKCSWDDESDDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CWU1</accession>
    <name>A0A3P9CWU1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CWU1"/>
    <dbReference type="Ensembl" id="ENSMZET00005027670.1">
        <property type="protein sequence ID" value="ENSMZEP00005026808.1"/>
        <property type="gene ID" value="ENSMZEG00005019996.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000193381"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="CDD" id="cd12893">
        <property type="entry name" value="SPRY_PRY_TRIM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="154"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="367" mass="41500" checksum="188C7A58D2C11BEC" modified="2019-02-13" version="1">MKTGFKVGLINEWKSCVLSWHGKVITHNSVLEPDCIPPLLSEHIKVQARHTERQIKEKFKKLHLFLAEEEEARLDALREEEEQKSGMMKEKMEALSRDIAALSDTIRATEEELRAEDISFLCSYKTAVERVQRCPLLDDPQLPSGALIDQAKHLGNLTFNIWINMKDVVSYTPIILDPNTAHPELILSEDVTSVRREGERQQLPDNPERFDYSCSVLGSEGFNSGTHSWDVEVGESTGWILGVSEESVERKGDIDSGLWIIWFYRGEYSASSPSAETVLSVEKKPQRIRVNLDWSRGKLSFSDPDTSHFFSSSSSSSYFGYFASFVQYVHYLTSHSRHSSSPTPPCLLSPSSLLCTVFCFGWLTPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CXA8</accession>
    <name>A0A3P9CXA8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Guanine nucleotide-binding protein G(olf) subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(s) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570788.1">
        <property type="nucleotide sequence ID" value="XM_004570731.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CXA8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027010"/>
    <dbReference type="Ensembl" id="ENSMZET00005027876.1">
        <property type="protein sequence ID" value="ENSMZEP00005027010.1"/>
        <property type="gene ID" value="ENSMZEG00005020149.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474191"/>
    <dbReference type="KEGG" id="mze:101474191"/>
    <dbReference type="GeneTree" id="ENSGT00940000155271"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000003">
        <property type="entry name" value="Guanine nucleotide-binding protein G(S) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006178">
        <property type="entry name" value="Guanine nucleotide-binding protein G(s) subunit alpha isoforms short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000367">
        <property type="entry name" value="Gprotein_alpha_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF233">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(OLF) SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00443">
        <property type="entry name" value="GPROTEINAS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="49"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="182"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="378" mass="43990" checksum="442D071F89366D83" modified="2019-02-13" version="1">MGCLGGKTDEERLDEKAKREANKKIEKQLQRERQTYKATHRLLLLGAGESGKSTIVKQMRILHVDGFNAEEKQQKVQDIRKNVKDAIVTIVSAMTILAPPIPLGNPGNQFRADYIKSIGPLSDFEYTEEFFEHAQKLWEDDGVKACFERANEYQLIDCAQYFLNRLESVRRPDYSPTDQDLLRCRVLTSGIFETSFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVAASSSYNMVIREDNSTNRLRESLDLFRSIWTNRFLKTISVILFLNKQDVLAEKILAGKSKLEDYFPEYNNYQLPADAVPDTDEDPKVMRAKFFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CXD5</accession>
    <name>A0A3P9CXD5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfotransferase</fullName>
            <ecNumber evidence="6">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004555837.1">
        <property type="nucleotide sequence ID" value="XM_004555780.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CXD5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026469"/>
    <dbReference type="Ensembl" id="ENSMZET00005027326.1">
        <property type="protein sequence ID" value="ENSMZEP00005026469.1"/>
        <property type="gene ID" value="ENSMZEG00005019749.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005027328.1">
        <property type="protein sequence ID" value="ENSMZEP00005026471.1"/>
        <property type="gene ID" value="ENSMZEG00005019749.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475274"/>
    <dbReference type="KEGG" id="mze:101475274"/>
    <dbReference type="CTD" id="562344"/>
    <dbReference type="GeneTree" id="ENSGT00940000166629"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002997">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF73">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044597188" description="Sulfotransferase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="8">
        <location>
            <begin position="56"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="63"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="306" mass="35050" checksum="9A9FAF485F530769" modified="2019-02-13" version="1">MLWTVLLALLVLLLLQTQLSVCLRELRSGGSSSSVYSPPSSSSSFYNATQQRLPGAIIIGVRKGGTRALLEMLNLHPDVEVAKAEVHYFNVEDHYRRGLAWYRAQMPFTVPGQLTVEKTPGYFAAPQVPARVSDMNPAVRLLLIVRDPAERLISDYTQVLHNRLTQHKPYKPLEELLLHKGHIDPGYKALQRSLYHQHLARWLEVFPREQIHVVDGDALIRDPFPELRKAERFLDLPPRINPSNFYYNTTKGFYCLLSSGHDKCLDESKGRPHAPLSTQALKKLCRYFRKPNKLFFEMVGRSFAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZM0</accession>
    <name>A0A3P9CZM0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease A-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the pancreatic ribonuclease family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZM0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027778"/>
    <dbReference type="Ensembl" id="ENSMZET00005028661.1">
        <property type="protein sequence ID" value="ENSMZEP00005027778.1"/>
        <property type="gene ID" value="ENSMZEG00005020711.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287131"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.130.10">
        <property type="entry name" value="Ribonuclease A-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001427">
        <property type="entry name" value="RNaseA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036816">
        <property type="entry name" value="RNaseA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023411">
        <property type="entry name" value="RNaseA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023412">
        <property type="entry name" value="RNaseA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437:SF10">
        <property type="entry name" value="ANGIOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11437">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00074">
        <property type="entry name" value="RnaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00092">
        <property type="entry name" value="RNAse_Pc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54076">
        <property type="entry name" value="RNase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00127">
        <property type="entry name" value="RNASE_PANCREATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ribonuclease A-domain" evidence="9">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005600"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="113" mass="12961" checksum="A04E530C8699F322" modified="2019-02-13" version="1">LLEHRGCDFLIANRNIRDNNGNCKRKNTFIISNFNQVKAICNGQGRYDQTNGTTKSVAKFRIVRCDLKNNGARKPKCQYKGTLLTNRIVVVTCEGKLPVHYYEAQRGRQRTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D504</accession>
    <name>A0A3P9D504_9CICH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D504"/>
    <dbReference type="Ensembl" id="ENSMZET00005030572.1">
        <property type="protein sequence ID" value="ENSMZEP00005029638.1"/>
        <property type="gene ID" value="ENSMZEG00005022105.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175631"/>
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        <property type="component" value="LG4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="140" mass="15070" checksum="BE4287009DAD5D48" modified="2019-02-13" version="1">INYRRSHQHENDKCFLVLVGAYPEVIGIHVELLRVHSAQFGVGLSDVVQVLHSIFQTTHHGLPVLCHFGVSHNGSVGGQVSKFFEVSLTPGAHNQKPGIRQETEKITILIPIHLSPQAVAVFDTGGILVGGGITGIGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6C3</accession>
    <name>A0A3P9D6C3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable serine/threonine-protein kinase kinX</fullName>
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    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004551341.2">
        <property type="nucleotide sequence ID" value="XM_004551284.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6C3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029646"/>
    <dbReference type="Ensembl" id="ENSMZET00005030580.1">
        <property type="protein sequence ID" value="ENSMZEP00005029646.1"/>
        <property type="gene ID" value="ENSMZEG00005022111.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101488112"/>
    <dbReference type="GeneTree" id="ENSGT00940000166048"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018129970" evidence="2">
        <location>
            <begin position="19"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="428"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="551" mass="62396" checksum="E5475B63B5716F23" modified="2019-02-13" version="1">MKMKTPALLSLSLAVALALPALPRGVEKSPVLTKENQLPLLGDSVPLQGHVQVENPAPQAVLPSKEQQEKVAEEDLKQNVAELEVKVKPDEEQEVKAEPEAEAEVEKAGVVELEVKVKPEVKVEEKSEAQQEAKAEVPVEAEAQMAGVNPEGEGDQELKDDPKFQVESEVKVEPDQLLMELEPEEKHMLDEENYQEPMQLQAHSGLEEEEEEYEEKVEEAEEESHNDMVDELEPLDDDNLFESELTEEEKAANAEFQSQESLIEPKPEEEEEEAKNEMVDEPIMELEPLDDNSPAEPLPEEELFMRKRDYALDQEPVMELEPEMMEEPFQNPSILEEGPALDIMEQPVSLMENYFPNEEAKMAARSEEQESPLAGEEKSQVQLYGEPETEDQIEPDDGEPTGLVSEEENRSRFKQAMQGRRSCPGVVLGEKCYQFFKGPKTPANAELFCQTFPGGHLASITSNHNHAELMKMILKENGKYTRTWIGGLRFLDTGRFIWLDGSKWDYADWLSGEPNNTANKENCLEVLPWGNGKFNDFTCWEPQAFICSYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7A3</accession>
    <name>A0A3P9D7A3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger translocation associated</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7A3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029971"/>
    <dbReference type="Ensembl" id="ENSMZET00005030914.1">
        <property type="protein sequence ID" value="ENSMZEP00005029971.1"/>
        <property type="gene ID" value="ENSMZEG00005022348.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00600000084617"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052675">
        <property type="entry name" value="ZnF_transloc-Spindlin_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34589">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2700081O15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34589:SF2">
        <property type="entry name" value="ZINC FINGER TRANSLOCATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="78"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="200"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="352"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="487"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="578" mass="64971" checksum="2ABFD15EB1DBE6C5" modified="2019-02-13" version="1">MTRIHVHTLQAGIHFSTQRPNEHEGGADGQTTLGRWGPDHPLLLSLAPGPSGAKPRVQRASRPGLSRIPGRDHRRYYHEYWRSEYLMDFDPQRHGMICMVCGSSLATLKLSTIKRHIRQKHPDSLLWSAADKEVIRSGWESHLSLGGGEVALFLQTGEAEPISLTPCSVEGEAPQPKEEEQYLPEPSAQILERYLNDSLHAWFRQEFLMEYESHAGRLLCMVCGAVLPSLHLDHIKSHLLDTHPNSLVYSSEEKHCILQAWTQTHDGELENTAQPPDLNPIELTNTKDGAVGLFSEDVETIQINTDVYTEGDGTFTQDTCLIGEDGGVGVPQQGLQPFRQPKKRRLHGGDPWRLRLDYLVAYGPQGHGMFCMVCSQVLHETKVSSFRRHIQECHPETTTLSRQEREAMAAAWTKDYPSEGMQIQDGEKENLWGPGSVKPGGSANRIACINIEEAVGEAKGKSKDSSAANTPRHGHYPGKDQRRNYQVRWRTDYLMDYDCRRHGLICMVCGATLATLKVSTIKRHVQQVHPHSLYFSAVEKQQALQSYNQTALHFIHSDDCFSPRDHGHTELKSNAICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8Z8</accession>
    <name>A0A3P9D8Z8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8Z8"/>
    <dbReference type="Ensembl" id="ENSMZET00005031544.1">
        <property type="protein sequence ID" value="ENSMZEP00005030582.1"/>
        <property type="gene ID" value="ENSMZEG00005022781.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161051"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF899">
        <property type="entry name" value="ASTACIN-LIKE METALLOENDOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017848377" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="61"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="250" mass="28155" checksum="64352A27ED94BA5B" modified="2019-02-13" version="1">MTPAFFFSICLSMTAVCLVSLTLPAKPLNVVQHCRLFCESNSNCVSKVLVHGDIVPTATRNAVPCTATGCKWPKRDALSMYLQERNVIINALVTFYASTCIRFVWRTSHRDFLHFFSGQGCYSYLGRQNGGQLVSLQRNGCLFQSTVQHEVLHALGFHHEQVRSDRDRHVRILTGNIITGQERNFVKVQTNNLGTPYDFNSVMHYGRLAFSKNGQPTIVARSNPNLNFGNAFRMSPNDIARVNRLYGCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9D1</accession>
    <name>A0A3P9D9D1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dapper homolog 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dapper family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574349.1">
        <property type="nucleotide sequence ID" value="XM_004574292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9D1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031178"/>
    <dbReference type="Ensembl" id="ENSMZET00005032185.1">
        <property type="protein sequence ID" value="ENSMZEP00005031178.1"/>
        <property type="gene ID" value="ENSMZEG00005023253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471273"/>
    <dbReference type="KEGG" id="mze:101471273"/>
    <dbReference type="GeneTree" id="ENSGT00950000183181"/>
    <dbReference type="OrthoDB" id="9886203at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024843">
        <property type="entry name" value="Dapper"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15919:SF1">
        <property type="entry name" value="DAPPER HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15919">
        <property type="entry name" value="DAPPER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15268">
        <property type="entry name" value="Dapper"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="578"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="665" mass="73508" checksum="C5A52A615D23AD30" modified="2019-02-13" version="1">MSFQDLRDSFETFSQYMKTGRSRNKERLQASLAGLCELGLLKQRQESRVLRALGIKDPSSTGGPDWGALCSELCAMDAPKGKESCGLNLHHSSLQFTPWGLSTSLEEQVAELKVDCEVKSSDSTDLDASQLISGKARVAKENGSSEMNCYPVTSCSLSAPEGSGEKETKKTYMSTLTRHAIVTGALGKLKEVDPSLYDYQQTQKVETYIFGVIQRRTLPTRPSKPRTSLAHDARVVNVVRQSSLCQKDEQHLPKQELAQEIIAPSQWSEGIASEAGLNLDQEQYLRIGPTEDPPLPYHLQQKGLYTKPRQASMTLLDYPHGKDVQPDSSTTEPDLSQRLPKYQSPPAAAAAAKSTQPSSPEDHLVSAEYIPGQPCRTSNRAYAHHHTNHHKGPGVSKSNRCAYSPERLYHQEQQPTAFHIQPPRYRGGPKKCRSNEDRGGASRKPGKKACRSQSENSLQRFPERKFNTVEKDGSGSGNAGRGSRGNQPRSKKQQQSSGSYRRSLSTLELSQDEADQPPVTIPVQSNQNCCLRRTRKPRPTHASYAYPTTSHHFHHHQHMEFQLERDQTQLCQATDDYSHAGQVESESSMSEADSPDSSSLSSDSDESGGLVWPQQLPPRLSLPSTLAPSGAPLQPKAFVKIKASHALKKKILRFRTGSLKVMTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9H5</accession>
    <name>A0A3P9D9H5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561645.1">
        <property type="nucleotide sequence ID" value="XM_004561588.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9H5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031350"/>
    <dbReference type="Ensembl" id="ENSMZET00005032364.1">
        <property type="protein sequence ID" value="ENSMZEP00005031350.1"/>
        <property type="gene ID" value="ENSMZEG00005023369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474783"/>
    <dbReference type="KEGG" id="mze:101474783"/>
    <dbReference type="CTD" id="30141"/>
    <dbReference type="GeneTree" id="ENSGT00940000164418"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021536">
        <property type="term" value="P:diencephalon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000064">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000435">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3510:FF:000004">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000347">
        <property type="entry name" value="delta-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 16" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12 14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 14 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018007957" description="Delta-like protein" evidence="18">
        <location>
            <begin position="21"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="20">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="422"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="627" mass="68980" checksum="56D8FE1FC7F9D616" modified="2019-02-13" version="1">MAHLHLRCLLALALVHVVLSSGVFELKIHSFHTAQRICRRHRDCHIFFRICLKHPEDVISAEPPCTFGTGQTNVIRADHTSISSSAPIRVPFHFKWPGTFSLIIEAWNAESPTEYTDNQNNLVSRLATRRRLAIGEDWSQDVHFGEQSELRYSYHVFCDEYYFGDGCADYCRPRDDTLGHYTCDEEGNRICLEGWKGNYCSEPICSAECSERHGYCEAPGGCTCRMGWQGPSCNECVRYPGCLHGTCSQPWQCNCQEGWGGLFCDQDLNYCTNHKPCTNGATCTNTGQGSYTCNCRPGFGGTNCELETNECDSNPCKNGGSCNDLENDYSCTCPQGFYGKNCEIIAMTCADGPCFNGGTCVETMTGGYTCRCPPSYTGSNCEKKLDRCSNRPCLNGGECLDLGQSILCRCQAGFTGANCQVNIDDCASSPCQNAGTCQDGVNDYTCSCTLGYTGKNCSVRSDACGAHPCQNGGTCFTHFTGPVCQCPKGFMGPSCEFTLQPSFKPALRQTSQPSSTTLTLSCALAILVLVLVAGILYLRRRRRMQGRKQLRDTAVYNDLETVNNLGGSERDAFLGPNGLFKISNSTARLSLSLCPDGRPGYRHNPVENSLSRGERQDFMWRDEAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAH2</accession>
    <name>A0A3P9DAH2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAH2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031354"/>
    <dbReference type="Ensembl" id="ENSMZET00005032368.1">
        <property type="protein sequence ID" value="ENSMZEP00005031354.1"/>
        <property type="gene ID" value="ENSMZEG00005023371.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155356"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14211">
        <property type="entry name" value="STKc_HIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000029">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000022">
        <property type="entry name" value="Homeodomain-interacting protein kinase 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF43">
        <property type="entry name" value="HOMEODOMAIN-INTERACTING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="190"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="770"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="870"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1052"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="945"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="960"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1096" mass="119752" checksum="7BD542B48A04FC1E" modified="2019-02-13" version="1">MASQLQVFSSPSVSSSAYSRSKRLKLGDNGYYQQSPTQGAAPSTSGSNFNQVYTSNQVHPPTAGSREQTVVRAADSTGSLCGPPSSSSSSSSSSRRIKDAESSSQPSDLYHKQYSLKRKSEEVDSSDSVQILEELSAPVVSNRNGGGGGGTTTAQSIAHSTSTTKSSNSHSEGDYQLVQHEILCSMSNSYEVLEFLGRGTFGQVAKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILSRLSTENADEFNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKHSKFSPLMLKCIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPLRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFNRGPDSSYPLWRLKTPAEHEAEMGIKSKEARKYIFNCLDDMMQVNMTNLEGTDILAEKADRREFIDLLKKMLTLDADKRITPMKTLNHPFVTMTHLLHFPHSSHVKSCFQNMDICKRRCSAFENGKNMFASNNTPSAATNLTVTFSSQLNQHNQMTSTGGQSLSLSSNVPLLNYQPGLYQQATINIPGLTQQGVPLQTRPTQLCTQTEPFQQTLIVCPPTIQGLQTSNKPSAYPVRMENSVPLVPQNQSSQSLHIQPSMLAQPLFHYPLGLAFFQHACVHVLTQQGWPAGTQQILIPSTWQQMPGMSIHNPGQAVVPEPPMGAHISDSQQTSAISLLCRGRHGSQYDSVNQHDSGAGRHTGTQNHSSGAAHSRSQQGKRSKARHAESRPSTSFAGDQSQPIVISDTPSPAVSIITIHSDSEDEDDTKFPAACQRTNVISCVTVHDSHDSDSSTSSPLSPKTSSQPTKSLAVIMPSVKSQPGESTTHKAPAASVKSKKASTQASGRSGDSTTERNQRAASSRSQPLNLSQLQQSVMPSSHEQTASSSSLRRQPTYPPPVSSHSSYRLHESTLFGSTPNLYAYPASAALASVSQAVDQMQGGTSRHGRASGAYSSLALLQKNSSLALGGSAPGQYGNNHQQQQQQQQQQLAAQPFQRSGAAYQRKLNQYPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCV0</accession>
    <name>A0A3P9DCV0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCV0"/>
    <dbReference type="Ensembl" id="ENSMZET00005033010.1">
        <property type="protein sequence ID" value="ENSMZEP00005031976.1"/>
        <property type="gene ID" value="ENSMZEG00005023847.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234820"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="66" mass="7504" checksum="48A0BEBC87A66C14" modified="2019-02-13" version="1">MSWLFLDWFVPLYLLVSVLVLAGFGACLYFLEPGLQDAHKWSNKTVRHHPLVASVNCRDDDSNALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFT1</accession>
    <name>A0A3P9DFT1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyribonuclease</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNase I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFT1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033239"/>
    <dbReference type="Ensembl" id="ENSMZET00005034363.1">
        <property type="protein sequence ID" value="ENSMZEP00005033239.1"/>
        <property type="gene ID" value="ENSMZEG00005024808.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182846"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10282">
        <property type="entry name" value="DNase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018057">
        <property type="entry name" value="Deoxyribonuclease-1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016202">
        <property type="entry name" value="DNase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371">
        <property type="entry name" value="DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11371:SF29">
        <property type="entry name" value="DEOXYRIBONUCLEASE-1-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000988">
        <property type="entry name" value="DNase_I_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00130">
        <property type="entry name" value="DNASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00476">
        <property type="entry name" value="DNaseIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00919">
        <property type="entry name" value="DNASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017971090" description="Deoxyribonuclease" evidence="8">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000988-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="271" mass="30720" checksum="2352BDC8E37C4A21" modified="2019-02-13" version="1">MHLVGTLGLFLTLLHLSNSLLLGAFNIKSFGDTKASNTTLMNIITKIVQRYDVILIQEVRDSDLSATQKLMEYVNKDSPQYKYIVSEPLGASTYKERYLFLYREALVSVAKSYTYDDGPEETGQDAFSREPFVVMFSSKHTAVRDFTLIPQHTSPESAVRELNALYDVVADVRARWNNDVFTAYNYVSGSDWQQIRIFTDKTFHWLITDAADTTVSQTVCPYDRIVVTADMMRGVVKDSAKVYNYMTDLNLKQDLALAVSDHFPVEVKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGS2</accession>
    <name>A0A3P9DGS2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Muscarinic acetylcholine receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGS2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033589"/>
    <dbReference type="Ensembl" id="ENSMZET00005034738.1">
        <property type="protein sequence ID" value="ENSMZEP00005033589.1"/>
        <property type="gene ID" value="ENSMZEG00005025083.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158450"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15300">
        <property type="entry name" value="7tmA_mAChR_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000047">
        <property type="entry name" value="Muscarinic acetylcholine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000522">
        <property type="entry name" value="Muscarinic acetylcholine receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF209">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR M5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0770">Synapse</keyword>
    <keyword evidence="11 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="22"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="58"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="409"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="38"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003336"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="RuleBase" id="RU361191"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="500" mass="56230" checksum="082C4F0CB69510C9" modified="2019-02-13" version="1">MGVVNTSTMDIHLVTHSLWEVITIATVSAIVSLITIVGNVLVMVSFKVNSQLKTVNNYYLLSLAAADLIIGVFSMNLYTSYILMGYWALGNLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSLVLWAPPILCWQYFVGKRTVPERQCQIQFFSEPVITFGTAIAAFYVPVSVMTILYCRIYKETEKRTKDLAELQGINCSTESGVAQPQKTIIRSCFSCKLSSASQDRNQASWSSSTRSNAVKSAATTSDEWSKAGQLTTFNSYASSEDEDRPSGVCSESEQLSSYDEESFFQTPPKSNSQKSSKCVSYKFKPVTKESHTEHQSRNGDTKITSPTFSSAESMSVPSTSTMSKPIDTTLKSQITKRKRMVLIKERKAAQTLSAILLAFILTWTPYNIMVLISTFCSQCIPVSLWHLGYWLCYVNSTVNPMCYALCNKTFQKTFRMLLLCQWKKKRIEEKLYWYGQNPVVSSKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DI88</accession>
    <name>A0A3P9DI88_9CICH</name>
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        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 186</fullName>
        </submittedName>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
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        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
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    </dbReference>
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    <sequence length="1006" mass="113702" checksum="07B5EC4391623221" modified="2019-02-13" version="1">MMEGSEVQSLTTASHQMNLLNVNTSNADEEEEISLNSAQEAETCSQAKDELQLDGESVKTTALAEMDTKTEHEAQICSHEHPDVKEEPVDTRTVLVESGKPPESPSNESGSTLVAPVPTVDVVENSPSVLKGTEDTVLTFDATIPNGNEQPSLLVTNCPTEPSPAEDSSSAESPSSSSVHSTSKNSPTDSTTTSGISNGPSTPISDTFSSSLASSPQTSAKNLFPSNSSASPYDTDCSRKLISQIQRSLSQESLLDELESELLACQLPHGDDRSERKGSSPVNGLPTDQEGCMVVFEKCVQYKYAQQEKAIQKLLEENKRHQELILGICSEKDKMRDELKRRTETEKQRFATITKLEAKVNELLKELKESRDKLVHQEQSAKAALQQMQKETGYRIEQVNKKCDEARQEKETMVMKYVRGEKEALDLRRDKESLEKKLREATKEVDRQALRGNQLAQEKGRLQQLYEAKEGEVGRLTRDVDKLKEEINSHLIKVKWAQNKLKSEADAHKETKDKLRETTSKLAQAKEETEQIRKNCQDMIRTYQESEELRSNELDAKLRETKGELEKHKQEQTDQLELHRVKAKELEDLKRSYKEAMDELDTLRTKLKCLEDERPRWEDELTKYREIINRQKTEIGRQREKLEEVTALQEQHQCDEQEIKSLRDEVDGLTNQMADLHRDVQGSREREAELLGFTEKLSSKNAQLQSESNALQSQLDQLTNNFTELQGKLEETNRLLEDKSQQLKQEEALRRQEVQSLQEERAALQTEVAQLKTRVEELRDELVTQKRKQAANIKDLTKQLTQARKRLEQVENGGCERDASSMGSRSSSSGSLNARHGGSSGVEERSPESQSGPSVVVVDSFPEVDKAVLVERIVRLQKALARKQEKIEFMEDHIKQLVEEIRKKTKIIQSYVLREETGALSSEASDINKAHLSRRGGIMASLYTSHPADSGLTLDLSLEINRKLQAVLEDTLLKNITLKENLQTLGAEIEKLIKQQRDPEDGVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK35</accession>
    <name>A0A3P9DK35_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carnitine O-palmitoyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.21</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12661"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17490"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="2.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:12662"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="4"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005034521"/>
    <dbReference type="Ensembl" id="ENSMZET00005035733.1">
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        <property type="gene ID" value="ENSMZEG00005020572.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286917"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015909">
        <property type="term" value="P:long-chain fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000002">
        <property type="entry name" value="carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000001">
        <property type="entry name" value="Carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF105">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="18">
        <location>
            <begin position="159"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="783" mass="88935" checksum="5609C19B23E88399" modified="2019-02-13" version="1">AFACSVNVALDLTVTIYSNGLLYISHQIKTLVNSLIKGVYPASPSSWLFVAIGILATMYMQSDPSMGLITKIQQHLPLHMSLSAQGQTMVSALVFSTLLWLSLILALRFCLKLLLSYHQWMFEKHGRMSNTTKVWVPLVRLLSSRKPLLYSYQSSLPHLPVPAIQDTVSRYLESVRPLLTDPEFKRMSDLANEFESNLGNRLQRYLKLKALWATNYVSDWWEEYVYLRSRGPIMVNSNYYGMDFLYVTPTSVQAARAGNTITALLLYRRKVNREELKPVRLRVPGTVIPLCAAQCERMFNTTRTPGVETDVLQHWLDSEFVAVYHRGRYFRLWVYRAGRLLSPREIEDQIQRILDDASPPLPGEEKLGALTAGDRIPWAQMRKQYFSSGVNKRSLDIIERAAFFVTLDDEEQGMRGDDPEGNLDRYAKSLLHGKCYDRWFDKSFSVVIYKNGKSGLNAEHSWADAPTVAHLWEYTLATDAFQLGYTEDGHCKGDVEPSLPQPQRLVWNIPAEVQAQVSSSLAVAQALADDVDCHVFPFREFGKGRIKKCRVSPDAFIQISLQLAYYRDRGGFCLTYEASMTRLFREGRTETVRSCSNESCAFITALESGETEEECRRLFQLASERHQNLYRMAMTGAGIDRHLFCLYVVSKYLGVESPFLKEVLSEPWRLSTSQTPVQQMNLFDLKNHPDFISLGGGFGPVADDGYGVSYIIVGEDMVNFHVSSKYSCSQTVSNVSVSWIDDLLYLLSCSPTPCNTFVNKMFYCVNPAYRPKKPGCLSWLCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK99</accession>
    <name>A0A3P9DK99_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DK99"/>
    <dbReference type="Ensembl" id="ENSMZET00005036427.1">
        <property type="protein sequence ID" value="ENSMZEP00005035180.1"/>
        <property type="gene ID" value="ENSMZEG00005026296.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000272271"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
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            <end position="200"/>
        </location>
    </feature>
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            <end position="313"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="409" mass="40435" checksum="8C16894C90C78B81" modified="2019-02-13" version="1">RFGTGEQPTAELRVRAISAAPEPTAAPKPVPEPTAAPEPVPEPPTTPEPFTAPEPTAAPEPVPEPPTTPEPAAAPEPTVTPEPVAEPSTAPEPTAAPKPVPEPTAAPEPVPEPTAVSKPVPEPSTAPEPTAVSKPVPELSTAPEPVTEPTATPEPIPESTVAPEPSTAPEPTAAHEPVTEPIATPEPTAAPEPIPEPSTAPEPTGAPEQTVTPEAVPVPSTTTEPTAASEPVPEPTAAPELTTAPEPIPEPSTAPEPTAASEPTAAPESTAASEPMTAPEPTAAPESTAASEPTAAPEPTAASEPTGASEPTAAPEPIPEPSTAAEPTAAPEPTAASEPTAAPEPIPEPSTAPEPKAAPESTAASEPSTAPEPTAASEPTAGPEPIPEPSTTPKQPDATEGTAAPEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLC9</accession>
    <name>A0A3P9DLC9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dishevelled segment polarity protein 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DSH family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_012917789.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLC9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035204"/>
    <dbReference type="Ensembl" id="ENSMZET00005036451.1">
        <property type="protein sequence ID" value="ENSMZEP00005035204.1"/>
        <property type="gene ID" value="ENSMZEG00005026314.1"/>
    </dbReference>
    <dbReference type="CTD" id="569863"/>
    <dbReference type="GeneTree" id="ENSGT00950000182903"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000001">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000040">
        <property type="entry name" value="segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000014">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024580">
        <property type="entry name" value="Dishevelled_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008339">
        <property type="entry name" value="Dishevelled_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003351">
        <property type="entry name" value="Dishevelled_protein_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEP"/>
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    </dbReference>
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        <property type="entry name" value="DIX"/>
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    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
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        <location>
            <begin position="256"/>
            <end position="328"/>
        </location>
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        <location>
            <begin position="406"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="681"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="182"/>
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            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
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            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
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            <begin position="599"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022687"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
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            <dbReference type="PROSITE" id="PS50841"/>
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    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="722" mass="79130" checksum="A7764BDCC3665EB8" modified="2019-02-13" version="1">MAETKIIYHIDEEETPYLVKLSVPPEKVTLADFKNVLNNRPVNSYKFFFKSMDQDFGVVKEEISDDNAKLPCFNGRVVSWLVLAESAHSDGGSQCTESHPELPPPLERTGGIGDSRPPSFHANAVSSRDGLDTETGTESLLSHRRERERERARRRARETELPRINGHSKSERTARDSAMGYDSASVMSSELESSSFVDSEEDEDASRLSSSTEQSSSSQLMRRHKRRRRRHKVAKIDRSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRILREIVSKTGPISLTVAKCWDPSPRSYFTIPRAEPVRPIDPAAWISHTTALTAPYPHYEFDDLPLSVSKTDMATIVKVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYSRVEGFKDRRDARKYASSLLKHGYLRHTVNKITFSEQCYYTFGDLCQNMASLNLNEGSSGGGSEQDTLAPLPPTSNPWPLGGQPFPYPPFPTAPPSFPPGYSDPCHSFHSGSAGSQHSEGSRSSGSNPSAGKGRRSSPQEKGQRSTCSESEPGIRGGRRGDRSASQMSHHSHAISSQSHARSSLSHSHSHRSHPVTQNNHPPFTYSHAAFTQPAPGSCAQSERSHASSYGPPGLPPPYCLARLAPKTSFNSSTPPGAPPGRELAAVPPELTASRQSFQHAMGNPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLL6</accession>
    <name>A0A3P9DLL6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Si:dkey-211g8.9</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLL6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035087"/>
    <dbReference type="Ensembl" id="ENSMZET00005036333.1">
        <property type="protein sequence ID" value="ENSMZEP00005035087.1"/>
        <property type="gene ID" value="ENSMZEG00005026241.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000203527"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045125">
        <property type="term" value="F:bioactive lipid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:response to fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013312">
        <property type="entry name" value="GPR40-rel_orph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45822:SF4">
        <property type="entry name" value="FREE FATTY ACID RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45822">
        <property type="entry name" value="FREE FATTY ACID RECEPTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01904">
        <property type="entry name" value="GPR40FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="263" mass="29363" checksum="765B506E5FA13BEA" modified="2019-02-13" version="1">DCIALIIYILTFLLGLPANLLVFFVYMRKARKHGATPNVVYALNLCLANLGLLVWLPVKTLETLLQDWRLPAPVCLVYNFFLFSSLYGSCLFITAVTAGRYFSIAFPIVYKRWRCARNSCIISAVLWLLVVLHLSPGVMVEEGGFFVSTGNNSSVCYEVFSASQLAVLLPLRLEMAITLFLLPLIVSTFCTMRCVTLVWRSKLSPMGKRRVLAVALSTLAVFVVCYAPYNASHVVGFVMGENVKWRTYAMLTSTCNVFLDPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMM9</accession>
    <name>A0A3P9DMM9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the citrate synthase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_014407415.3"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005035457"/>
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        <property type="gene ID" value="ENSMZEG00005026492.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471407"/>
    <dbReference type="KEGG" id="mze:101471407"/>
    <dbReference type="CTD" id="1431"/>
    <dbReference type="GeneTree" id="ENSGT00390000006813"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
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    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:citrate synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:citrate metabolic process"/>
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        <property type="entry name" value="ScCit1-2_like"/>
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    </dbReference>
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        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
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    </dbReference>
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        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
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        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00045710"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="469" mass="52247" checksum="96FD3982463AC864" modified="2019-02-13" version="1">MSFLTVTRLAPKLLNSKNASFLFVAARNASASTTNLKDVLSDLIPKEQTRIKNFKQQYGKTNIGQITVDMVYGGMRGMKGLVYETSVLDPEEGIRFRGYSIPECQKLLPKAPGGEEPLPEGLFWLLVTGQVPTEEQVNWVSKEWAKRAALPSHVVTMLDNFPTNLHPMSQFSAAITALNSESSFARAYSEGVHKSKYWEFIYEDSMDLIAKLPCIAAKIYRNLYREGSSIGAIDSNLDWSHNFTNMLGYSDPQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFSAAMNGLAGPLHGLANQEVLVWLTALQKELGGEVSDERMRDYIWNTLKSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPSDPMFKMVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYQMTEMNYYTVLFGVSRALGVLAQLVWSRALGFPLERPKSMSTDGLMSLVGAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMV2</accession>
    <name>A0A3P9DMV2_9CICH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
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        <name type="common">zebra mbuna</name>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSMZET00005037028.1">
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        <property type="gene ID" value="ENSMZEG00005026713.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00600000085659"/>
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        <property type="component" value="LG20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="156" mass="15931" checksum="D81BA2508CB262C9" modified="2019-02-13" version="1">MQRCLKGRAGALEMIDTFDRPGRAFTEDTFARAGTFADAFEDKPGKRLPKAGVYAEAGVGHARAEWSVFDAEDKGPNASTGAGASVASGAQAFARAEIASASASAGPVKASVGLGLDTGVGISPTGVEVKVLGMGISLGRKMGISLFGTGFEFNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNK3</accession>
    <name>A0A3P9DNK3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM domain and actin binding 1a</fullName>
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    </protein>
    <organism evidence="7 8">
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        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004560301.1">
        <property type="nucleotide sequence ID" value="XM_004560244.3"/>
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        <property type="nucleotide sequence ID" value="XM_004560245.4"/>
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    <dbReference type="Ensembl" id="ENSMZET00005036979.1">
        <property type="protein sequence ID" value="ENSMZEP00005035716.1"/>
        <property type="gene ID" value="ENSMZEG00005026681.1"/>
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        <property type="protein sequence ID" value="ENSMZEP00005035717.1"/>
        <property type="gene ID" value="ENSMZEG00005026681.1"/>
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    <dbReference type="GeneID" id="101463960"/>
    <dbReference type="KEGG" id="mze:101463960"/>
    <dbReference type="CTD" id="64000"/>
    <dbReference type="GeneTree" id="ENSGT00940000158313"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="LIM_Eplin_alpha_beta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM domain and actin-binding 1"/>
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        <property type="entry name" value="Cysteine Rich Protein"/>
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    <dbReference type="InterPro" id="IPR028740">
        <property type="entry name" value="EPLIN_Lim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
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            <begin position="317"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="76"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="395"/>
            <end position="430"/>
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            <begin position="444"/>
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            <begin position="80"/>
            <end position="95"/>
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            <begin position="96"/>
            <end position="130"/>
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            <begin position="135"/>
            <end position="159"/>
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            <begin position="188"/>
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            <begin position="568"/>
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            <begin position="590"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="706" mass="77170" checksum="3708AA683AAFC774" modified="2019-02-13" version="1">MASVAPFSRRQWASQSLRVTAKELSIVSARGKNTAIAERFSKYQMAAEEGSIEKKKTVVEALPSTLCGGNLSALKKRWEQQQQQEPPSIQRSQSQAPLTPVSTLPGSRSAPSSQIKLQQDSLKTTVLSQDQDTEIQVHRVTRETSQDMTDMEAKPSRDSEEQEGAAASAAEVPECEKPSIPLNSLKMMFEKGESPEKASREQTGRGNTGSMDQLLGDGSLAESTPLRDRMALYQAAISKQEVPPASVNDDQLDGFSGKQKENVPPCTLDMSPESEPNTRRIFTSETNGSGPGTPASSNQKDSSQSKTPRNFRLPVRETCASCLKTVYPLERLVANQNVYHSSCFRCSHCNTKLSLANYASLHNSVYCKPHFSQLFKAKGNYDEGFGHRPHKELWEGKNESAEASPTSVTKPTAQSPATPSDQESPSVEDSPLAKVNVLTATMEALGQGSSEKADKPTETRRLKISWPPKTEPEDTPSRGGAAANTEVVSTGKPIRAKWPPEEDSPSTPPEEARGSPVLRRNTPLKERSMPFTAAAQPDSPPAPEPKKQSAPVERQPSPEPASMDLQHGGQSSDSQTPTEDSCVDVHTSSGEEEQEEEMKSEDATDHHLPTEEDLDDAAGGQGEEEEQMEEEDGGVLEEDMPDAKLQETPTEPTAVSSPEAEVEASRSSQDVGFWDSEEEHEELTVEELIKRNRHYEEEEEEEEGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS02</accession>
    <name>A0A3P9DS02_9CICH</name>
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        <recommendedName>
            <fullName evidence="13">Metal transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metal transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ACDP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS02"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037224"/>
    <dbReference type="Ensembl" id="ENSMZET00005038527.1">
        <property type="protein sequence ID" value="ENSMZEP00005037224.1"/>
        <property type="gene ID" value="ENSMZEG00005027743.1"/>
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        <property type="component" value="LG13"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative metal transporter CNNM3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057492">
        <property type="entry name" value="Ig_CNNM1/2/4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF80">
        <property type="entry name" value="METAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25511">
        <property type="entry name" value="Ig_CNNM4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="16">
        <location>
            <begin position="192"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="459"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="725"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="780"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="837"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="891" mass="99355" checksum="560454EF1FC38EF7" modified="2019-02-13" version="1">MAADAADALCSILHPRRLSLLFLTVTISSLPAKTTALLGVRPEDTQSGELSVQDGILRAVEGTRFMLRVYYSASPGTENPNSLNISGRPDAAPAAPWIAFIEEPGGDSGDAESPLLSRGNPCEEENARSSDIELLGSFRSTSSHNSVLVELLAKDLRRDEVIKYYSMCAFDGVKWEHLSTKDFWLAVVERPPEADAWLQAGVSVLLLGLSALCSGLNISMLSLDPVELRVLQNSGTEKEQKYARKIESVRKHGNYILCTVVLGNVLTNTCFVVWMCQILGMTALSTASCTLGIFFIGEILPHSVASRHSLAIASKTLCATRLLMLIFFPIAYPVSKILDIMLHQEISNFYTREKLVAMLRVTDPYHDLVKEELNIIQGALELRTKTVEDVLTPLSDCYMLSSDAALDFCTMSDVMQSGFTRIPVYENERSNIVDILFVKDLAFVDPDDCTPLKTITQFYKHPMHCVFSDTKLDVMLEEFKRGKSHLAVVQRVNSEGEGDPFYEVMGIVTLEDVIEEIIKSEIVDETDLYTDNRTKRRVSNHERKQQDFSIFKVAENELKVKISAQLLLATHRFLATEVEPFRPCHLSEKILLRLIKHPSVVQDLKFNPKNKHAPQHYLFQRNKPVDYFILILQGRVEVEIGKEALRFENGAFSYYGMPAVIPPLPIGQRYSSRASSLNQSDSLLSGGSVGQLTAGGGVYLPDYSVRQLTDLQIIKITRNHYHNALTATRMDSSPQTPEAVDTDGKGRPPVPEARSHSIALPLTHTHTRLGLARLAHLHPHGGLRSTSQLNERNRIVRSKSDGQRSPNDTVFLRMDEIPYIHEDRPESHGEDDVPTESQPSTSPFISSLSLSSSEENIGKKLLRKLSNKRRKKSRDGENSLEEGSEQQPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS80</accession>
    <name>A0A3P9DS80_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS80"/>
    <dbReference type="Ensembl" id="ENSMZET00005038408.1">
        <property type="protein sequence ID" value="ENSMZEP00005037112.1"/>
        <property type="gene ID" value="ENSMZEG00005027652.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000173563"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF12">
        <property type="entry name" value="CYSTATIN C (AMYLOID ANGIOPATHY AND CEREBRAL HEMORRHAGE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="131" mass="14935" checksum="17ED0204E2DD56F4" modified="2019-02-13" version="1">GSIYLHKPLQGLMFAWFFVFVFVCASAAEQTMTGEPRRVPVNDTRVLTAAHFAVAEFNKVNAGEMFAYKTVVAGIKYILDMLLGQTVCSRNHLNVLICHFFQEYQCHFVVVEVSWEKSRVLSKNECHQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS95</accession>
    <name>A0A3P9DS95_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPRY-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS95"/>
    <dbReference type="Ensembl" id="ENSMZET00005038446.1">
        <property type="protein sequence ID" value="ENSMZEP00005037148.1"/>
        <property type="gene ID" value="ENSMZEG00005027679.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286950"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPRY-associated" evidence="6">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="172" mass="20307" checksum="B2124DD6CB5E515E" modified="2019-02-13" version="1">MDEHKHHDIVPAGTERTEKQKQLSVTLHKSQQRIDQRVKKWQDLRQAVESLKHSAQTVLEENERIFTELLLSIERKYIEVKEMIRTHERTTVTQAETLLDRLEEEITLLKKKHNDLELLSHTDDHIHFLQAGQLILDVNTVHPNLHLSEGNRAATMKNEPKNYPDHPDRFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AT27</accession>
    <name>A0A3P9AT27_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563353.1">
        <property type="nucleotide sequence ID" value="XM_004563296.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004563354.1">
        <property type="nucleotide sequence ID" value="XM_004563297.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024654979.1">
        <property type="nucleotide sequence ID" value="XM_024799211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AT27"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000844"/>
    <dbReference type="Ensembl" id="ENSMZET00005000920.1">
        <property type="protein sequence ID" value="ENSMZEP00005000844.1"/>
        <property type="gene ID" value="ENSMZEG00005000740.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473070"/>
    <dbReference type="KEGG" id="mze:101473070"/>
    <dbReference type="CTD" id="564608"/>
    <dbReference type="GeneTree" id="ENSGT00390000016940"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF16">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="9">
        <location>
            <begin position="39"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="364" mass="40530" checksum="B99B04EA67513C52" modified="2019-02-13" version="1">MTTTLETMLAQPDLELGPDRMDGCEAARGHYKVVPSVVCSMCCLFGIIYCFFGYRCFKAVMFLTGLMFGSVVIFMLCYKERVLDTQLSVEASVGIGLGIGTLCGLVTMLVRSVGLFMVGLLLGLLVAVATLVGMEELSDSPPRSVWVPLGVLLGLGMLFAVLTLQWQRLFTTLSTAVFGAAVITVALDYFVELFALVLYMYERIKAESGKPVCWMTWVVLGVWPALTLLGVVVQWKVTAEGYSHTKVIISRQQRRMQVMRIRQRDDRYRNKKKKKQQHGSSSHHQHQSKQLHTEPAYRRKPNPIRRYDTDVLSPSYIQSFRDRQVQAQPFPGRLVGGSHAVVEMGYDCGSTTPLTGAAGPSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATP0</accession>
    <name>A0A3P9ATP0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MCF.2 cell line derived transforming sequence</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATP0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001041"/>
    <dbReference type="Ensembl" id="ENSMZET00005001125.1">
        <property type="protein sequence ID" value="ENSMZEP00005001041.1"/>
        <property type="gene ID" value="ENSMZEG00005000848.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156974"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF207">
        <property type="entry name" value="PROTO-ONCOGENE DBL-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="491"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="687"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="805" mass="93134" checksum="54587B049B65067E" modified="2019-02-13" version="1">MAESNPLRGFPRLRRAATSFPGNLHLILVLNPSSLLSSAPSPSSSTDLGFRFSQDDFLLKMPVVMLRSVGDLLRYIDENHLTTDFTAKVQFCQSDWVVLRTLQSIETFAVTVKEIAQLLQSFGSELSDTELPDEANAIEFLLHSHTHRYRQMKDDIRNVLKEGRLLLSNLETVKASKRDAEEEREIQADMDTVKLLAQLGDMEEAFDGFFEKHHLKLQQYLQLLHYESSFQQMEEVLERLSAQEKEIASLGNTVVQTEQLLKDLDTLDKRAQEEMARAQVLILHGHQLAANHHYALALIIQRCNELRHYCDVITIAIRTKRASLTRTRDLLGCLEEALRWCDEGAYLLASQMVDKFQTREGAQEALQYLSCHQERAPSAMKNSQDTLSFEFQAILTPQLQSQISMVTEKLNSMQCMIRNREQCLRKLADVQVRPIQLVAPRPEPDQTFQRCKSPLFSPKHIEVMHDYQGNRSCLYGPNPETDSEAEDNPEQVTHIMKELIATERIYVDELLSVLLQGYRAEMEDPSVANLLPVALRSQKDVLFGNMPEIYQFHSIFLQDLQSCLETPESVGACFLKRKEKFQVYERYCQNKPRSELLWRQCADSLFFQCQKKLDHKLGLDSYLLKPVQRLTKYQLLLKLLKHCTEERYRCELQEALDSMLELLKSVNDSMHQIAITGYQGDLSHLGRVVMQGSFSVWISHKRAAVRMKELARFKPMQRHLFLYEHALLFCKRRDEDNHDRAPFYSFKSCLRMSAVGITENVKGDVKKFEIWYSSREVVYIVQAPTVEVKVAWLMEIRKILNNQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATS7</accession>
    <name>A0A3P9ATS7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-pass membrane and coiled-coil domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMCO4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATS7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001104"/>
    <dbReference type="Ensembl" id="ENSMZET00005001192.1">
        <property type="protein sequence ID" value="ENSMZEP00005001104.1"/>
        <property type="gene ID" value="ENSMZEG00005000952.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015987"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027960">
        <property type="entry name" value="DUF4519"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34644:SF2">
        <property type="entry name" value="SINGLE-PASS MEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15012">
        <property type="entry name" value="DUF4519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="84" mass="9494" checksum="1464DB07C7FDDC27" modified="2019-02-13" version="1">MNTLCRDTHDSGSSEHSKTNHHLVVMRQLKGKPKKETSKDKKERKQAMQEARQQVATVVLPTLAVVVLLIILFVYVATRPDAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUF5</accession>
    <name>A0A3P9AUF5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gap junction protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">A connexon is composed of a hexamer of connexins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the connexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563772.1">
        <property type="nucleotide sequence ID" value="XM_004563715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUF5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001037"/>
    <dbReference type="Ensembl" id="ENSMZET00005001119.1">
        <property type="protein sequence ID" value="ENSMZEP00005001037.1"/>
        <property type="gene ID" value="ENSMZEG00005000895.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466479"/>
    <dbReference type="KEGG" id="mze:101466479"/>
    <dbReference type="GeneTree" id="ENSGT01030000234513"/>
    <dbReference type="OrthoDB" id="9441654at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005922">
        <property type="term" value="C:connexin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.80">
        <property type="entry name" value="Gap junction channel protein cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000500">
        <property type="entry name" value="Connexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019570">
        <property type="entry name" value="Connexin_CCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017990">
        <property type="entry name" value="Connexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013092">
        <property type="entry name" value="Connexin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038359">
        <property type="entry name" value="Connexin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984">
        <property type="entry name" value="CONNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11984:SF29">
        <property type="entry name" value="GAP JUNCTION BETA-5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00029">
        <property type="entry name" value="Connexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00206">
        <property type="entry name" value="CONNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00037">
        <property type="entry name" value="CNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01089">
        <property type="entry name" value="Connexin_CCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00407">
        <property type="entry name" value="CONNEXINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00408">
        <property type="entry name" value="CONNEXINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0303">Gap junction</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Connexin cysteine-rich" evidence="12">
        <location>
            <begin position="141"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="270" mass="31439" checksum="75FADED781EC0E5A" modified="2019-02-13" version="1">MNWIFLEGLLSGTNKYATRFGRIWLAIVFIFRLLVFLVACEKVWGDEQKDFDCNTRQPGCQNVCYDHYFPISYTRLWALQLIFVTCPSLLVTLHVSYRKDRERKHRLKYGEDCTPLYDNTGKKRGGLWWTYFFSLLFKITVDGVFVFLLFYLYEAAFFPPLVKCREEPCPNVVDCYIARPTEKKIFTVFMVVTSFVCIFLTLCEVLYLCGKRFRECCKKGPRSMRDNSFMMTRVPLSGNENSAYKEPVLEKSVTNGEPGQKGSAPPYTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUK1</accession>
    <name>A0A3P9AUK1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec31A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">SEC31-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SEC31-related protein A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUK1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001351"/>
    <dbReference type="Ensembl" id="ENSMZET00005001441.1">
        <property type="protein sequence ID" value="ENSMZEP00005001351.1"/>
        <property type="gene ID" value="ENSMZEG00005001132.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003175"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000001">
        <property type="entry name" value="Protein transport protein Sec31A isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000009">
        <property type="entry name" value="Protein transport protein Sec31A isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000011">
        <property type="entry name" value="SEC31 homolog B, COPII coat complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF22">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC31B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="19">
        <location>
            <begin position="573"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="791"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="941"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1206" mass="130889" checksum="E45B140820E887FC" modified="2019-02-13" version="1">MRLKEIQRTAHQAWSPAGHHPIYLALGTAAQQLDASFNTTAAIEIFEMDFSDPSLDMQLKGSLATTNRLHSIVWVNFGSGADGTGGRLVGGSENGTLTVYDPEAIMNSSGEAVVGQSDKHTGPVRALDFNHFQSNLLASGANDSEIYIWDLNNFSSPMTPGAKTQPAEDISVVSWNRQVQHILASANPSGKAVVWDLRKNEPIIKISDHSNRMHCSGMLWHPDVATQLVLASEDDRLPVIQMWDLRFATSPLKVLENHTRGILSISWSQADSELLLSSAKDNRILCWNPNTGEVIYELPTTNQWCFDVEWCPRNPALLSTASFDGRITVYSVMGGSLKAQQQSTAERISSSFDTMDPFGTGQVLPPLQVPQPQVQDTIVPPLKKPPKWVRRPVGASFAFGGKLITFENPKLPPVQSPQPVPRQVFVSQVTTETEFLQRSRELQTALQSGSFNSYCQAKIQSSKSDAEQDIWKFLLVNFEDEARIKFLKLLGFSKDELERKISKCLGKNFQPNGHGVDAKDLAEKMQRLSTERSDEAAEARTSGSVSPADFFSQTPKENSNFQIPVSCDTDGLISQALLVGNFEGAVDLCLNDGRYAEAILLSISGGEELLKKTQQKYLSKQKNSISMLISSVVTQNWKDIVQSCELDNWKEALAALLTYAHPEDFARLCDTLGSRLECEGTEKRCLQACLCYICSGNIEKLVECWALYRDCSSPLGLEDLVEKVMMLRKSIERLRNCEVAVQSPVLAEKLTCYAGILAAEGSLTTALSYLPENSDQAGIVMLRNRLFHAQGEAPVQQQPPNTFNRVSVSTAKPTPAAPTPASKAQFTSHYQPSPAAQMTAQQQPPLPSVFTPQAAPTNPGPGWLEPSSHVLPPSTTRPALRPSYPQHPAVAPGFLPHQPFQPQSPSTAGPPVFPPPGPSMPAATLSGPQLPPSSSAAGGLPPMPSPGVPPISFMPPTPSGFAPPRSQPGAPVPVYPGSLHNQGTAPPSVPYVPPGSGYPQGGPGAPAAKPFPAPVVAPPPTGSQEGWNDPPTVRGGPRKKKVPDNYTPPAPITAPVMRFPVEAAQPHDNTQVPPGAPQEPSVQLLQQLPSEKVQQKEIPPEHMVLKSTFDSLVQRCQLAAGDPQTKRKLDDAAKRLGHLYDKLREQSLSHNILSGLHEISRCVASQNYQRGLEVHTQVVSSSNFSEISAFMPILKVVMTIANKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVD4</accession>
    <name>A0A3P9AVD4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 151Ba</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM151 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550505.1">
        <property type="nucleotide sequence ID" value="XM_004550448.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVD4"/>
    <dbReference type="Ensembl" id="ENSMZET00005001768.1">
        <property type="protein sequence ID" value="ENSMZEP00005001675.1"/>
        <property type="gene ID" value="ENSMZEG00005001370.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486398"/>
    <dbReference type="KEGG" id="mze:101486398"/>
    <dbReference type="CTD" id="100006371"/>
    <dbReference type="GeneTree" id="ENSGT00390000013762"/>
    <dbReference type="OrthoDB" id="190434at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026767">
        <property type="entry name" value="Tmem151"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31893:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 151B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14857">
        <property type="entry name" value="TMEM151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="510" mass="58373" checksum="979778884E216399" modified="2019-02-13" version="1">MSPASAATASESATATTTVPEEETESPREEQQPQKQSLAKSLCQETHWKCLLLSLLMYGCVGVMAWCQVTEVTRLTFNSAYKGNSMMYHDSPCSNGYIYIPLAFLVMLYVVYLVECWHCYTRNELQYKVDVDSVTERIQRMQQATPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHVAEAEFDYGNCGVKDISKNLLGLDGFPITKLRFTKCFSFANVESENSYLNQRARFFTENEGLDDYMEAREGMHLKNVDFKEYMIAFSDPDHLPWYASNSTFWVAAAFTLSWPMRVLTEYRTSCVHYHVEKLFGFDYVPVTPSDERVYCRHIPRVNTIDSTELEWHIRSNQQLVPSYSEAVLMDLAQLSGSCNSYSLSGGYGSYRQNCERCHRAISSSSIFSRSALSICNTGSPRIPFSASRFSLGRLYGSRRSCLWRSSGSLNEQSCPTESTRCLSGQQASEENPPAYQDALYFPVLIVHRNEGCLNHDHRSLHRNGSCVETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVF9</accession>
    <name>A0A3P9AVF9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVF9"/>
    <dbReference type="Ensembl" id="ENSMZET00005001700.1">
        <property type="protein sequence ID" value="ENSMZEP00005001609.1"/>
        <property type="gene ID" value="ENSMZEG00005001321.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177588"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47888:SF1">
        <property type="entry name" value="SERTA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47888">
        <property type="entry name" value="UPF0730 PROTEIN ENCODED BY LINC00643-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15827">
        <property type="entry name" value="UPF0730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="64" mass="7132" checksum="A208C210E4978DD3" modified="2019-02-13" version="1">MYPDRKRVKVLVTDCCSPGFGLEELQHYRLVPCYPSAGCLYSLGTCPGLTPNHQVLLYNLDDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVQ2</accession>
    <name>A0A3P9AVQ2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="RefSeq" id="XP_004561258.1">
        <property type="nucleotide sequence ID" value="XM_004561201.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVQ2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001785"/>
    <dbReference type="Ensembl" id="ENSMZET00005001880.1">
        <property type="protein sequence ID" value="ENSMZEP00005001785.1"/>
        <property type="gene ID" value="ENSMZEG00005001437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471898"/>
    <dbReference type="KEGG" id="mze:101471898"/>
    <dbReference type="CTD" id="36"/>
    <dbReference type="GeneTree" id="ENSGT00940000156525"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="57"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="172"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="279"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="433" mass="48262" checksum="F7A2C2A355C18D85" modified="2019-02-13" version="1">MAIPLVRIFSKSFKQLSRPWGACQAGWRSTSSRSVPDVASHHPAEVVSSFPPLQTYTEEEGMMREAVKKYAQERIFPLVSQMDENSQMDKEVIKSLFEQGLMGIEIDPEYGGTGSSFFSSILVIEELAKVDPSVAVLCDIQNTLINTLFVKLGTPAQKEKYLNRLSTDMIGSFCLSEAESGSDAFALKTRAEKHKDYYVINGSKMWISNAEHAGVFLVMANVDLSAGYRGITCFIVDRDTEGLEIGKKENKLGLRASSTCPLNFDNVKVPEKNILGEIGHGYKYAIGMLNEGRIGIAAQMLGLAQGCFDHTVPYTRQRVQFGKRIFDFQGMQHQIAHVATQIEAARLLTYNAARLKEAGRTFIKEACMAKYFSAEVATLTTSKCIEWMGGVGFTKDYPIEKYYRDCKIGTIYEGTTNIQLSTMAKFIDKEYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVQ8</accession>
    <name>A0A3P9AVQ8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ADAM metallopeptidase domain 9b</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561264.1">
        <property type="nucleotide sequence ID" value="XM_004561207.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVQ8"/>
    <dbReference type="Ensembl" id="ENSMZET00005001822.1">
        <property type="protein sequence ID" value="ENSMZEP00005001728.1"/>
        <property type="gene ID" value="ENSMZEG00005001420.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473447"/>
    <dbReference type="KEGG" id="mze:101473447"/>
    <dbReference type="CTD" id="570656"/>
    <dbReference type="GeneTree" id="ENSGT00940000166115"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000002">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018358">
        <property type="entry name" value="Disintegrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF136">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00289">
        <property type="entry name" value="DISINTEGRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00427">
        <property type="entry name" value="DISINTEGRIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018232773" evidence="11">
        <location>
            <begin position="20"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="14">
        <location>
            <begin position="210"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="13">
        <location>
            <begin position="414"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="12">
        <location>
            <begin position="642"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="736"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="738"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="365"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="818" mass="88726" checksum="891F80EECBC9CFD4" modified="2019-02-13" version="1">MIIKNHILITVFVFSFISGIDNKDAFQGFTSKLSKYSIVNPQAIHRGSRSINRQHHLKDKYGDETVSYAVNINNQKHVIHLKKNRDFLHPNFVQYSRDAAGNYNTSYPKEHVHCYYHGEVEGYKDSMVALSTCSGLRGVIFFENKAFGLEPVPQSTTNDHLLYLLEDVQTEPITCGVVTEATSVPSHEPFEPGQSLTSLLRRKRNLPQTSYVELVLVVDNLRYTFKKNNATAVREEMVQMANLLDGYYKQLNIRVVLVGLEIFKDSNPFSVDGSAGNVLGNFVQWRKTFLIPKIRHDIGQLIVGQSGAYPGGVLGMAFVGTVCSASSSGGINVFSNNNLAFVSTVVAHEMGHNLGMNHDSANCACNGKSCIMSGGASGATNFSQCSEADFEALILRGGGLCLRNQPAASNVISNPECGNGLLEQGEQCDCGKPQECTNKCCNAATCTFTHGSACAHGACCENCQLKVAGTPCRNSVNTCDLPEYCNGRNESCPNDFYLMDGLPCENNAAYCYEGRCQTYDYQCGHLFAPDNAIKAADICFQVANIQGDQFGNCGSNSNGNYIKCTLANTMCGKVQCTNVNVNNPPPGATVTIKIVAGKTCVNADFNLGTDVLDPAYVNPGSPCATGKTCVNFQCVNASALLPNLICDAKTTCNGRGVCNNLGHCHCENGWGPPYCDRSGWGGSIDSGPAQIDYSLRNGLLIFFLLVVPLLVLLILVLLYIFRRESLEPCLKRLRKTQTKNTNAGSNSNAQTGARPIPPPERPTNRPAFPAAASTPVSGFKYGETNYWDDENSHDPPEQPPPVQGPGVPRPIQPKHLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZD4</accession>
    <name>A0A3P9AZD4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentraxin family member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pentraxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZD4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003023"/>
    <dbReference type="Ensembl" id="ENSMZET00005003139.1">
        <property type="protein sequence ID" value="ENSMZEP00005003023.1"/>
        <property type="gene ID" value="ENSMZEG00005002348.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000248591"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000012">
        <property type="entry name" value="neuronal pentraxin receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051360">
        <property type="entry name" value="Neuronal_Pentraxin_Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030476">
        <property type="entry name" value="Pentaxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001759">
        <property type="entry name" value="PTX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277:SF3">
        <property type="entry name" value="NEURONAL PENTRAXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19277">
        <property type="entry name" value="PENTRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00354">
        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00895">
        <property type="entry name" value="PENTAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00159">
        <property type="entry name" value="PTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00289">
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    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="36"/>
        </location>
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            <begin position="1"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="196" mass="21677" checksum="2363A4614D606D3C" modified="2019-02-13" version="1">MRTNYMYGRMRRSVVTEIFALTICLWLKAGAGPGLGTPFSYSVPGQANELVLIEWGSNPMELLINDKAATLPITMTDEKWHHVCVTWSTRDGVWEAYQDGAKKGTGQNLSAWHPIKPGGIFILGQEQDTMGGRFDVTQSFVGELSDLQFWSRVLTSSEIYSQATCGGHLVGDVMSWSEESVELHGGLTELSFDPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0V4</accession>
    <name>A0A3P9B0V4_9CICH</name>
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        <submittedName>
            <fullName evidence="14">Extracellular calcium-sensing receptor-like</fullName>
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    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
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        <property type="gene ID" value="ENSMZEG00005002738.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Taste 1 receptor member 2"/>
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        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
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    </dbReference>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
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        <property type="entry name" value="GPCR_3"/>
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        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
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        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF528">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="698"/>
            <end position="721"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="733"/>
            <end position="753"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="13">
        <location>
            <begin position="539"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="805" mass="89387" checksum="A5ADBD60952D7853" modified="2019-02-13" version="1">MDGDYVIGGVFPIHYYMQTVNHDYTTIINTRELRFSRAMVFAIEEINNSTELLPGIRLGYQIYDSCSSVPVAVHVAFQLLNSLDTVFYTGGNCSLSGMVMTIVGESGSTPSISMSRILGSFNIPQVSHYATCACLSDKQQYPNFFRTIPSDRFQAEALAKLVKHFGWTWIGAVRSDSDYGNSGMASFLEAAQKEGICVEYSKFLNVLHSFLRSTAVVIVAFVASGDMKILLEELSREPSPPRQWIGSESWITDSEFRRFNFCAGAIGFGIQKSVIPGFRDFLLNLSSSQVATSPMLTEFWEESFNCKMKKSEKILLIFSNFCPVVDKKICDGTEDIQNLQIPYTDTSQLRITNMVYKAVYAIAHAIHNTVCQRTNGIAKCDKLNKLESKQVTELKKVNFSQNGYDVSFNANGDPVAIYELVNWQKSETGKTELVTVGLYDASLPIGQEFQINQSITWLEDDTQVPVSVCSASCPPGTRKVLQKGKPICCYDCILCPEGETSNTTDSADCLPCHKEFWPNAKRDTCIPKPVEFLSFEDILGIILATLSVLGACLAITTVAIFFHHGTSPIVRANNSELSFLLLISLTLCFLCSLTFIGAPSEWSCMLRHTAFGITFVLCISCVLGKTIVVLMAFKATLPGSNVMKWFGPPQQRMTVVSFTFIQVLICTIWLVLSPPFPIKNLTTYKEKIILECALGSAVGFWAVLSYIGLLAAFCFVLAVLARKLPDNFNEAKFITISMLIFCTVWITFIPAYVSSPGKFTVVVEIFAILSSSFGLIMCIFAPKCFIILFNPEKNTKKYLMNKNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0Y2</accession>
    <name>A0A3P9B0Y2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activating protein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0Y2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003372"/>
    <dbReference type="Ensembl" id="ENSMZET00005003504.1">
        <property type="protein sequence ID" value="ENSMZEP00005003372.1"/>
        <property type="gene ID" value="ENSMZEG00005002618.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153904"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04376">
        <property type="entry name" value="RhoGAP_ARHGAP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000017">
        <property type="entry name" value="Rho GTPase activating protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041852">
        <property type="entry name" value="ARHGAP6_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037863">
        <property type="entry name" value="RHOGAP6/36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12635:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12635">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="256"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="786" mass="87897" checksum="8582ECA963A1E3E7" modified="2019-02-13" version="1">MSAQGLLSTVFSCSLSPKSIAKRRLRQTRSLDSALMRHCGTEAEETSTKGDFTWNSLSGGTVGLKPVPLQSLSELERVRLQDVAFKRLLRCHDLGCHITIPKYGHKHKKTLRRKLDSLSKEKSKDKDTTPQAFGIPLSHVISNDRMHKLRHDHPREEHSDPTELMLSFLHLTSSYKRANKELSSSNSSLSSTSETLNESPLPSTPDIAPRTRRRGGVSVDCITDLDDNQSRLLEALQLSLPEEAAGNTKKHHDEKLSLNPIYRQVPKIVDQCCQHLEKYALQTIGIFRVGSSKKRVRQLREEFDQGWEVYMDEEHSVHDVAALFKEFLRDMPESLLTKELYTAFINTMLLNFLEQDSAIQLLVFMLPPCNSDTLQRLLSLLSTVSAHAEDSLDSEGHKVTGNKMTSLNLATVFGPNLLHKQKNSDKEFAVESFARAEESAAIIGVVQKMIDTYDTLFMVPPDLQNELLMSLQETDPDVVDYLLRRKASQCSEPSLRSEESFSLTDRRLSSDSHKPSSGEVSPYDNNSPVLSDRPRFKYTEDGSLLSDRVPRQDKLRDQSKDNSGSTSPTLSTDKETSADSFWDTWHELFGKDFTGIAGYLGDVSECDSYGSSEGLSSHQGNNKLPVSATQMSLGVSECRPHPPVTRCSSGPDDQREQRHPESLLLHQAMSSQSGAVSSDNLAQRTGCTECPLLQVRTDSLSSLNCSRPLRETHISHSTPSLLKSQHDPQIPQQSQQSADFKIVDTADATGPGEEKGPDSSNWQKERWHIWKMMSKENPEALPETLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0Z0</accession>
    <name>A0A3P9B0Z0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial proton/calcium exchanger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Electroneutral mitochondrial K(+)/H(+)exchanger</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Leucine zipper-EF-hand-containing transmembrane protein 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) + 2 H(+)(out) = Ca(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72199"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>K(+)(in) + H(+)(out) = K(+)(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29467"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LETM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554821.1">
        <property type="nucleotide sequence ID" value="XM_004554764.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0Z0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003544"/>
    <dbReference type="Ensembl" id="ENSMZET00005003677.1">
        <property type="protein sequence ID" value="ENSMZEP00005003544.1"/>
        <property type="gene ID" value="ENSMZEG00005002737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475753"/>
    <dbReference type="CTD" id="3954"/>
    <dbReference type="GeneTree" id="ENSGT00950000183167"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099093">
        <property type="term" value="P:calcium export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000290">
        <property type="entry name" value="LETM1 and EF-hand domain-containing protein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059005">
        <property type="entry name" value="LETM1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF8">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26561">
        <property type="entry name" value="LETM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15 24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 23" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="28">
        <location>
            <begin position="265"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="27">
        <location>
            <begin position="688"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="488"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="562"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="488"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00035046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="765" mass="87341" checksum="5372064DBC75640B" modified="2019-02-13" version="1">MALILFTRSRAPLMKTSRSLKNEFRKGKGKLQEGSYFSCTAFTLSSQKPDGLRLGSLAQVSSFGPSLPVSDEFVGPCQSSDAQRLYCAFASGASSSMYPAVGVGPQWTIVRPRDISGVRWIHTTRRRWDDSKVEKSLRSLKDKKKLEEGGPVYSPTLDAEPVRRTLRQWVVDEIKHYYHGFRLLWIDTTIAGRMFWRVLNGHPLSRRERRQFLRTCADVFRLLPFLVFIIVPFMEFLLPVALKLFPNMLPSTFETQTKKEERLKKELRVKLEMAKFLQDTIEEIALRNKAAKGDVTEEFSTFFQKIRDSGERPSNEQIIKFSKLFEDELTLDNLTRPQLVALCRLLELQSIGTNNFLRFQLIMKLRAIRADDKLIAEEGVESLNVNEVQAACRVRGMRSLGVTEERLREQLGQWLELHLNQQIPTSLLLLSRAMYLPDTLSPADQLKTTLQTLPEMVTKEAQLMAAELELSKVDNKTKLETMLQEEAAIRQDNKDREMERLADAAEKAAREGEPELQAERMKRSEAEPASSKAEKAADSETLKDTAPIIEGLKAEEITKEEIDLLSDACSKLKEQKKLLTLEKEELEELKDDVQEYNEDLEEIKKELSKTGQEKAIEESKASQRLSKRVNRMIGRIDKIILELEKDKVILDGQMDSGSTPPVGLFYTFRENLVSIDELINIMRQIQNIPEHKLQSIAEALDDNKDGKIDIDDVIKVVELIDKEDIDISTSQVADIMVMLQKEEKLMGKEKAKEKAEKEQAATLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1K1</accession>
    <name>A0A3P9B1K1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Potassium channel, subfamily K, member 10b</fullName>
        </submittedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Cs(+)(in) = Cs(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78555"/>
            <dbReference type="ChEBI" id="CHEBI:49547"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Rb(+)(in) = Rb(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78547"/>
            <dbReference type="ChEBI" id="CHEBI:49847"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004540431.1">
        <property type="nucleotide sequence ID" value="XM_004540374.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B1K1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003607"/>
    <dbReference type="Ensembl" id="ENSMZET00005003757.1">
        <property type="protein sequence ID" value="ENSMZEP00005003607.1"/>
        <property type="gene ID" value="ENSMZEG00005002776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485944"/>
    <dbReference type="CTD" id="565629"/>
    <dbReference type="GeneTree" id="ENSGT00940000156147"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000043">
        <property type="entry name" value="Potassium channel subfamily K member 10 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003976">
        <property type="entry name" value="2pore_dom_K_chnl_TREK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF32">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01499">
        <property type="entry name" value="TREKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="158"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="256"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="494"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="559" mass="61982" checksum="F1614106D5E5CC9F" modified="2019-02-13" version="1">MAVQTNLVPPKKVQPGMVKSTLVQASVATMQNPMGCDPKASGHCPLPRLSISSRSASVVASMDTNSDGSTTGLHSVMKWKTVLAVFIVVVLYLVCGGLAFKALEQPFESNLKTSITLEKASFLERHPCVTPNELDAIIKHAIDSVSGGVRPTGDTLYNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFVKSVLKVEKIFRQKHKQISQTKIRVTSVILFILAGCIVFVTIPAVIFKHIEGWTTLDAIYFVVITLTTVGIGDYVAGGNRKIDYMKWYKPLVWFWILIGLAYFAAVLSMIGDWLRVLSKKTKEEVGEFKAHAAEWKANVRAEFRETRRRLSVEIHDKLQRAATIRSMERRQLGLEQRAHSLDMLSPEKRALFASLDASRFKTSSQESIDSKLNNLRLKGACEPYDHQGNEQTQETASSSEENLFNLRFGSLSKLARRNKNRELRRNIPEDVRRASLSINNGSAMLGEEGTEEEEDGEPDEENKERKEGNTSLTNLSQYTMERSKLNGFTPALAKDSENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2I4</accession>
    <name>A0A3P9B2I4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein max</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myc-associated factor X</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="similarity">
        <text evidence="1">Belongs to the MAX family.</text>
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        <property type="term" value="C:SMAD protein complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:determination of ventral identity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:hemopoiesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="MAX isoform 13"/>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
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        <property type="entry name" value="bHLH_dom"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
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        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
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        <property type="entry name" value="HLH"/>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
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            <begin position="51"/>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50888"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004111.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2Z8</accession>
    <name>A0A3P9B2Z8_9CICH</name>
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            <fullName evidence="17">Receptor-type tyrosine-protein phosphatase F</fullName>
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        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004271"/>
    <dbReference type="Ensembl" id="ENSMZET00005004451.1">
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        <property type="gene ID" value="ENSMZEG00005003235.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="IgI_2_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IgI_3_RPTP_IIa_LAR_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="R-PTP-F-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000066">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000015">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000082">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000128">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000098">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000353">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase F isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF9">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1226"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="210"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="299"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="394"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="492"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="587"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="689"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="789"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="887"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="984"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="21">
        <location>
            <begin position="1315"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="1490"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="21">
        <location>
            <begin position="1602"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="22">
        <location>
            <begin position="1779"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1870" mass="209018" checksum="81F38B2C48735732" modified="2019-02-13" version="1">VVPESSPQRTPSFIKSPEDQTGISGGVASFVCQAVGEPKPRITWMKKGKKVSSQRFEVIEFDDGSGSVLRIQPLRTHRDEAIYECTATNSVGEINTSAKLTVLEEDQIPHGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEIYWFKDFLPVDISSSNGRIKQLRSGALQIENSEESDQGKYECVAVNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEVMPGGSVNLTCVAVGAPMPYVKWISGEVELTREDEMPIGRNVLELTNIRQSANYTCVAISSLGMIETTAQITVKALPKMPTSLTVTETTATSVTLTWDSGNPEPVSYYVIQYRAKLSENGFQEVDGVATTRYSIGGLSPFSEYEFRVMAVNNVGRGPPSSIVDTRTSEQAPSSPPLHVQARMLSSSTMLVQWEPPEEPNGQIRGYRVYYSSDHDAPLSAWQKHNTDDSHFTTISGLATDITYSLRVLGFTSVGDGPPSDTLQIKTRQGVPAQPSDFDGEAELDSRIMLSWLWPVQEPIISFELVYWEANNPTDKHRVTFDAAGSYAVDGLKPDTLYVFSLAARSEMGLGVFTQPIECRTAQSTPSAPPQEVHLLSLSSTSVEVRWVAPPTDSQHGEIVGYSLAYQALTGEDQKRHQVSGIGPDITSYILEDLEKWTEYLVWVRAHTDVGPGPESSAAKVRTKEDVPGAPPRKVEVEALNSTALRVSWKPPLSVKQHGQIRGYQLVYSRLENGEPHGQPVILDVNLPEAQEAFIAGLLPETTYSVTVAAYTTKGDGARSKAKVATTTGAVPGKPTMMISTTIGNTALIQWQPPKEMVGEHMGYQLQYKRAEEEAFTIKHFKKTDDHFTVTGLHKGAVYIFKLCAKNRAGNGEEYVKEISTPEDIPSSYPQNLSVVGLTATSTKLAWDPPPLAERNGKIVKYVVMYRDINSPNNSTNVTTDTQMTVYGLQPDTTYDIRVQAFTSKGGGPISPSIQSRTMSTSMPVFTKNFGVKAVTKTSVLLTWEVPETYKSQVPVKILYNQQSVEVQGNLKRKLITQLQPDTDYSFVLMSRGNSAGGLQQQVSIRTAPDLLTVKPAQHHIDVEEGGKVTISLPKVPDAAAVRWYYIVVVPVTPVSLRRWENPEDMDIQELLESGADSSLQRRKRQSNDFLQPYIAAKLDTLPEIFTLGDEKKYSGFYNKPLPGQQQYRCFVLADLTDHETFAASPFSDPFTVKISGVIRQPQEDPEMLWVMGPVLAVILIIIIVIAILLFKRKRTSPAKDEHMAGVKDSLLAHSSDPVEMRRLNYQTQGMREHPPIAVCDLADHIERLKANDGLHFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILTPVDGVPGSDYINANYIDGYRKQNAYIATQGPLPETLSDFWRMVWEQRTCTIVMMTRLEEKSRVKCDQYWPSRGTETYGMIQVTMLDTLELATYSVRTFALYKNGSSEKREVRQFQFLAWPDHGVPEYPTPTLAFLRRIKSCNPQDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKSVDIYGHVTCMRAQRNYMVQTEDQYIFVHEALLEAAVCGNTEVPARNLYAHIQKLTQVAAGEAVTAMELEFKKLANSKAHTSRFISANLPCNKFKNRLVNIMPFESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYMATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDLFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5B6</accession>
    <name>A0A3P9B5B6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Palmitoyl-CoA hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>butanoyl-CoA + H2O = butanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:40112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549285.1">
        <property type="nucleotide sequence ID" value="XM_004549228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5B6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005070"/>
    <dbReference type="Ensembl" id="ENSMZET00005005294.1">
        <property type="protein sequence ID" value="ENSMZEP00005005070.1"/>
        <property type="gene ID" value="ENSMZEG00005003930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464402"/>
    <dbReference type="KEGG" id="mze:101464402"/>
    <dbReference type="CTD" id="55856"/>
    <dbReference type="GeneTree" id="ENSGT00390000013934"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="28">
        <location>
            <begin position="53"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="142" mass="15113" checksum="620B0C73E343AF53" modified="2019-02-13" version="1">MASLTLNSLKHVMRAMVDSPGFDRVLSKVDILSASPGKVVCEMRVEEEHTNRGGTLHGGLTATLVDIVSTIAIMHSERGAPGVSVDMNITYMNAAKMGEDVLITAQVLKQGRSLAFATVDLTNKVTGKIIAQGRHTKHLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9F4</accession>
    <name>A0A3P9B9F4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pleckstrin homology and FYVE domain containing 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9F4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006510"/>
    <dbReference type="Ensembl" id="ENSMZET00005006808.1">
        <property type="protein sequence ID" value="ENSMZEP00005006510.1"/>
        <property type="gene ID" value="ENSMZEG00005005036.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160728"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01218">
        <property type="entry name" value="PH_Phafin2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="PH_Phafin"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE-rel"/>
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    <dbReference type="PANTHER" id="PTHR46280:SF2">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="280" mass="32267" checksum="DD55D5509174FF57" modified="2019-02-13" version="1">MMDHPTFERENQERVQAVESSFHQAGKPLSKPGRILIGEGTVFKQGRKKIQQKILFLFTDILVYGSIVVPGRWYKKQKIIPLEDIELEDLEDSDIFKHQWLIRTPSKSFFVSAPSYEEKKAWIEHINECRSSLMQGTSCKPSKKFAVSWIPDPAACKCMRCLSTKFSGVNRRHHCRNCGFLVCNSCSKQRAVIDHIHPTKKLRICSFCYKNINEEKFRDRGDSAGKSSSEEEEFCPSGEENEKVEEGEIGIYSPSNWLDTKNGTWERLSIYDYPKSIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAC7</accession>
    <name>A0A3P9BAC7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetyltransferase 8-like 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAC7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006741"/>
    <dbReference type="Ensembl" id="ENSMZET00005007041.1">
        <property type="protein sequence ID" value="ENSMZEP00005006741.1"/>
        <property type="gene ID" value="ENSMZEG00005005195.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182932"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF58">
        <property type="entry name" value="8B (PUTATIVE,_PSEUDO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="236" mass="26475" checksum="57440565D6BC17DC" modified="2019-02-13" version="1">QQPCHLVIRRYRPADKDTVLTLFSTGILEHIRPCFYNAMTSPLYLTITSTLCVVGYLLGSVFGAVLFPAAWVGLIYYCCHEVYATVVRVRLRNDMQDIPGNFLSRPDDCFWVAEAEVGARAQVVGMVAVVAKHSGTEKYGEMFRMIIFPQYRRMGLGFRLTQTAVDFCKERGFSKVVLQTTSTQMAAVVLYSKFVDGNSQKYRLRVVHTVASVHMLSADKLASPQIDCKRATPAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCL8</accession>
    <name>A0A3P9BCL8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCL8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007511"/>
    <dbReference type="Ensembl" id="ENSMZET00005007827.1">
        <property type="protein sequence ID" value="ENSMZEP00005007511.1"/>
        <property type="gene ID" value="ENSMZEG00005005747.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234537"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057667">
        <property type="entry name" value="HTH_SB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="Tc1-like_DDE_dom"/>
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            <begin position="1"/>
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            <begin position="71"/>
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    </feature>
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        <location>
            <begin position="149"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37716" checksum="4968EB056AC6FCF4" modified="2019-02-13" version="1">MAKTKELSKDTRKSIVDLHQTGKSESTIGKQLGVKKSTVGAIIRKWKTYKTTDNLPRSGAPRKISSRGVKMIMRTVSKDPRTTRGDLVNDLQRAGTKVTKVTISNTLQRQGIKSRSARRVPLLKPVHVQARLKFAREHMDDTAEDWENVMWSDETKVELFGIDSTRRVWRKKNTELHPKNTIPTVKHGGGNIMLWGCFSAKGTGRLIRVKDRMNGAMYREILSQNLLPSVRTLKMKRGWVFQHDNDPKHTARATKEWLRKKHLKVLEWPSQSPDLNPIENLWRELKVRVARRQPQNITALEKICMEEWAKIPATVCANLVKTYSKRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDU2</accession>
    <name>A0A3P9BDU2_9CICH</name>
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        <submittedName>
            <fullName evidence="9">SRY-box transcription factor 3</fullName>
        </submittedName>
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        <name type="common">zebra mbuna</name>
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            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="Ensembl" id="ENSMZET00005008365.1">
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        <property type="gene ID" value="ENSMZEG00005006007.1"/>
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    <dbReference type="KEGG" id="mze:101485414"/>
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    <dbReference type="GeneTree" id="ENSGT00940000162359"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:otic placode development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:peripheral nervous system development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="High mobility group box domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF111">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
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    </dbReference>
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        <property type="entry name" value="SOXp"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00398">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
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            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="300" mass="33491" checksum="38F67FDB64C3A90F" modified="2019-02-13" version="1">MYNMMETELKTPLPQSNSGSAPGAKNNSASDQERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGADWKLLTDSEKRPFIDEAKRLRAMHMKEHPDYKYRPRRKTKTLLKKDKYSLPGGLLAPGTNPVNNAVSVGQRMDGYAHMNGWTNSAYSLMPDQLPYPQHHSMNSPQIQQMHRYEMAGLQYPMMSSAQTYMNAASTYSMSPAYTQQTTSAMGLSSMASVCKTEPSSPPPAITSHSQRACLGDLRDMISMYLPPGGDSAEHSSLQSSRLHSVHPHYQTAGTGVNGTLPLTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BE23</accession>
    <name>A0A3P9BE23_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008006"/>
    <dbReference type="Ensembl" id="ENSMZET00005008327.1">
        <property type="protein sequence ID" value="ENSMZEP00005008006.1"/>
        <property type="gene ID" value="ENSMZEG00005006101.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157259"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="97"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="596"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="786"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1099"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1099"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1306" mass="143264" checksum="DB14083E10B11F78" modified="2019-02-13" version="1">MTQGGGVPAMRAAHGCLLFPQRGEKMAAVSSGGAAGSAAAGITHSARPTHAGMGSQNRAQPSSGISHSGRTSTATGCITNPGHTSVPRPPPARVGHYEIERTIGKGNFAVVKLATHIITKAKVAIKIVDKTQLDEENLKKIFREVQIMKLLKHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKDARKKFKQIVAAVHFCHCRSIVHRDLKAENLLLDHNLNIKIADFGFSNMFSRGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTDCEYLIRHMLVLEPSRRLTMEQICKNKWMRQGDPDPDFDRLIAECEQVKTEREMELINEQVLMAMCEMGLDRERTLQSLQTDAYDHYSAIYSLLADRLKKHKNLRVAQPTLRPISYPLNAVQTDPQGNPVSITVPHVQLINPENQIVEPDGSMALDSDEGEEPSPEAMARYLSMRRHTVGVPDQRTEMQEDLQKLPPGFPRGALPQPPFIPLAPTMGQMHTLMPTQSLQPTQQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQLLKRPRGPSPLVTSPHPIPAVAPVDEEGSDGEPDQEAVQRYLANRSKRHTTHTLMSTSHGEPSAESQRPQGPRQRVGWVPDTHTRSSYKDCNTLHLPMERFSPVRRFSDGAATIQAFKAHLENSSLIKQLKQECEQLQKMYAIQQDEKLLEHTQQQHILYQQEQQILHQQIQGLSLGHGESQPSHLTHQLQRLRIQPSSPPPTQPSNHLFRQPNQSSPPGSAGIMQGHGQSSVQYQHGAPAMYQGQSGSPPPTGLPRVSLQTNPQAASARPTVPLAQGVPQQQQVTIQVQEVELGGGAQRQSNFLSTPGGHRVLGKQLSADNAESHSRSLGRFTSGYDQAQFNPHLYSGDAASRGASGVVGSYSPYLQGASLKVPGLEGYQTGAVGTNNYGAPSTLQQALLSPTPLDYRPPQQHVTPTLQGLLSPRHSLTGHADPRLPPQDLAALLKRQSPRPCPAPPTPSSGAPQEYGDMLLLRQLGPGESLEPQAPQGASGGQHYHHLLQIRPPEVQQQQQAPCPSLPHSESMEEDEVPASYHHPHEGLLAKTGEGHELLGPPRGGTPPYTSPTHRHGGYIRTGTGNRESEHVECRPQGQAMEVPDHNGVGYSRGPQGEVYRSRGQLQRHHTIQTCDDAYDQADPMSGMSLLAGKALSSARMSDILSQTSLTGSQQLHQREESVCDVEGELHAAACYPSSCTSDMLLSYKPPDLQYSMEQAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFU2</accession>
    <name>A0A3P9BFU2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mesoderm specific transcript</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004548320.1">
        <property type="nucleotide sequence ID" value="XM_004548263.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BFU2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008780"/>
    <dbReference type="Ensembl" id="ENSMZET00005009120.1">
        <property type="protein sequence ID" value="ENSMZEP00005008780.1"/>
        <property type="gene ID" value="ENSMZEG00005006655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479042"/>
    <dbReference type="KEGG" id="mze:101479042"/>
    <dbReference type="CTD" id="4232"/>
    <dbReference type="GeneTree" id="ENSGT00510000047602"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000041">
        <property type="entry name" value="Mesoderm-specific transcript homolog protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018262328" evidence="8">
        <location>
            <begin position="21"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="62"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="326" mass="37608" checksum="F11DFEF42E8A0CA7" modified="2019-02-13" version="1">MREWWIHVGLICIPLVAVYLHIPPPQLSTALQKWHSAGKVFHFRGWKIFYRDSLGALGSSDVIILLHGFPTSSYDWSKIWDPLTQRFHRVIALDFLGFGFSDKPRPHKYSIFEQASVVEALVAHLGLSNQRVNLVSHDYGDTVALELLYRSDQNRTGHLTLNSLCLSNGGLFPETHHPRLLQMLLKDSSFLAPILTRLTNFVIFQKGIGEVFGPYTQPTDAEFWDMWTGLRYNDGNLVLDSILQYINQRLKHRERWVGVLTSTYVPLHMIYGPLDPVNPHPQFIRLYQKLVQKSTVTILDEHISHYPQLEDPTGFLNAYFNFIHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BG05</accession>
    <name>A0A3P9BG05_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BG05"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008822"/>
    <dbReference type="Ensembl" id="ENSMZET00005009163.1">
        <property type="protein sequence ID" value="ENSMZEP00005008822.1"/>
        <property type="gene ID" value="ENSMZEG00005006697.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175258"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38564">
        <property type="entry name" value="SI:CH73-250A16.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38564:SF2">
        <property type="entry name" value="WU:FC46H12 PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018208293" evidence="1">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="162" mass="17848" checksum="1F3D4B27CBC6608E" modified="2019-02-13" version="1">MDLRFLFLSSSLIVGATLSISPAERTAHCKIKWLFGISCSNVSERLVSQIKAWQISRSCLYAGEQCSYELVSSAPNLIIATHTSPRTKKVNDLQFLVEHQHVSDEQGEAVSQFSTDPADNGTNYCSMQNLMDGSTLSDAEGYKKFSNKWICPGFDAAKCALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BG82</accession>
    <name>A0A3P9BG82_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neugrin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Neurite outgrowth-associated protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the neugrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554322.2">
        <property type="nucleotide sequence ID" value="XM_004554265.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BG82"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008929"/>
    <dbReference type="Ensembl" id="ENSMZET00005009273.1">
        <property type="protein sequence ID" value="ENSMZEP00005008929.1"/>
        <property type="gene ID" value="ENSMZEG00005006770.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101485641"/>
    <dbReference type="CTD" id="51335"/>
    <dbReference type="GeneTree" id="ENSGT00390000014472"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF4">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="307" mass="33893" checksum="86D9BDD134083137" modified="2019-02-13" version="1">MARSVQILSLLSKFGAPSLISSVSATNCRFASRGAGKARMGQGPAQADRGSSRPGYSDQTSNGELELEDVEDKLQALIQEERKRQKTVKYHILRRQMTPSGAPERKLTWDAIEQIRHLKQNQPDEWTVERLAEGFSVSHDVILRVLRSKFVPSPERKAKQNAKVMAKMSQQVLPSGARTQQDRLKLPERNSQAILPPGSTEGALIPVANQTPVIQGHGSRSLAKSPVPVTVQPTHIAAGISEDATVTETTERSTNDSDLTEEDEESWDGQVLTQEELEELVKMEKPSPAVQVGNDFFDADGNFLYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BH82</accession>
    <name>A0A3P9BH82_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neurexophilin and PC-esterase domain family member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BH82"/>
    <dbReference type="Ensembl" id="ENSMZET00005009607.1">
        <property type="protein sequence ID" value="ENSMZEP00005009257.1"/>
        <property type="gene ID" value="ENSMZEG00005007013.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182866"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF9">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="2">
        <location>
            <begin position="336"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="547" mass="61529" checksum="D7A38931D2DD1C37" modified="2019-02-13" version="1">MKFLLYKHSTCLPKPGYIFVFLIVFVLILIIYIVDILDVSFFFIISATVTQPADMYSNFCKLKPLSPEEALEEHLVLESIAWPKTPPLPSPLSLNNTSDPAHSTFTILPRKRGEQWYIGDKLEVMIKMYDFQGYPKKSGGDVLLARLHNLTLGAGAAGHITDYLNGTYSAVFSLLWEGSAQVQVILVHPSEAVTELRRMNKEEPDRIFFKSQFRSSLFTRTTTCNVCLRPTEQPVCNYTDLHTGEPWFCYKPTNLSCNARISNYNGGYKKNLTTMEKCSFQILGVNMKVSIPASGPASVTILPKQKGQSEVSSSSGESKPSGYYYQGVWRALDGSTVQQFNTSSAITQCLKGKVVHMYGDSTMRQWFEYLNASLPDLKEFNLHSPKSIGPLMALDYANNIFVTHRAHGPPLRTVNVPSMELHYIANELDNVVGGSNTVVVFGIWAHFDNFPIEFYIRRLMSIRRAVVRLLSRAPGTVVVIRTGNPNLLHPLRLKALRAVFKGFNVHLVDAWEMVLAHHLPHNMHPQPPIIKNMINVLLSYICPQKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHF9</accession>
    <name>A0A3P9BHF9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase 6</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004543518.1">
        <property type="nucleotide sequence ID" value="XM_004543461.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004543520.1">
        <property type="nucleotide sequence ID" value="XM_004543463.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012772426.1">
        <property type="nucleotide sequence ID" value="XM_012916972.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BHF9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009318"/>
    <dbReference type="Ensembl" id="ENSMZET00005009668.1">
        <property type="protein sequence ID" value="ENSMZEP00005009318.1"/>
        <property type="gene ID" value="ENSMZEG00005007063.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465607"/>
    <dbReference type="KEGG" id="mze:101465607"/>
    <dbReference type="CTD" id="5597"/>
    <dbReference type="GeneTree" id="ENSGT00940000154351"/>
    <dbReference type="OrthoDB" id="8806754at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07854">
        <property type="entry name" value="STKc_MAPK4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000136">
        <property type="entry name" value="mitogen-activated protein kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000223">
        <property type="entry name" value="Mitogen-activated protein kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008350">
        <property type="entry name" value="MAPK_ERK3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01771">
        <property type="entry name" value="ERK3ERK4MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="758" mass="86019" checksum="625C5C291C2FFDB2" modified="2019-02-13" version="1">MAEKFESLMNIHGFDLGSRYMDLKPLGYGGNGLVFSAVDTDCDKRVAVKKIILTDPQSVKHALREIKIIRRLDHDNIVKVFETLGPSGRRLTEDVVSLTEVNSVYIVQEYMETDLCQLLERGLLSEDHARLFMYQLLRGLKYIHSANVLHRDLKPANLFVNTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVLRDEDRQELHSVIPVFIRNDMTKPHTPLAKLLPDVSPQALDFLEKILTFNPMDRLTAEEALAHPYMADYSFPLDEPVSLHPFHIEDEVDDILLMDQSHSHTCDRYHESQFSEADWHLHSTHDPDEVQVDPRALSDVTDEEVVQVDPRKYADGDREKFLDEPSFDYSTPFPLERSWQDDHHENKYCDLQCSHTCNYKAVSPSYLDNLIWRDSEVNHYYEPKLIIDLSNWKEQQSKEKADRKSKSKCEKNGLVKAQIALKEAEKSPVEKDKVQEKHQTEKPQSQQNQGFDFDSFIASTIKLSLQPEPCQEVTLLNDVGLLNEVGLLNELNFSVSQLEAPRSTSMSKSISQEKEEKCLVNLAQLGGGGLGVVGGDCVWPARPWESSGDTVGENGILIDEACWDIGKEDHLQKESPYTSYLDHLFSRREEAVSETASPQIGSPVVRELDESFLDRSTEIVLNMQLDSLALPGFDSTDELPLKSIQASLTPCAVKCSPQIAHKTYSSIFKHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIU0</accession>
    <name>A0A3P9BIU0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIU0"/>
    <dbReference type="Ensembl" id="ENSMZET00005010216.1">
        <property type="protein sequence ID" value="ENSMZEP00005009854.1"/>
        <property type="gene ID" value="ENSMZEG00005007461.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286973"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002353">
        <property type="entry name" value="AntifreezeII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00356">
        <property type="entry name" value="ANTIFREEZEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="161" mass="18411" checksum="114A0BC1C3833D52" modified="2019-02-13" version="1">SDSDSDYCVVICINSPLYNMQQTVKLQHGNCPTYWWSFNGRCYTYVATPMSWSDAEFHCLSQGANLVSIHNMEEENFVRSLIRNFDPAQRPTWIGLSDVHREGRWMWSDGSVVGFVNWNAGEPNNLAGKEHCATNNFSSHKKWNDCPCSLSFSSVCLKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJW3</accession>
    <name>A0A3P9BJW3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NIPA magnesium transporter 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJW3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009936"/>
    <dbReference type="Ensembl" id="ENSMZET00005010302.1">
        <property type="protein sequence ID" value="ENSMZEP00005009936.1"/>
        <property type="gene ID" value="ENSMZEG00005007498.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155651"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="384" mass="41206" checksum="B2E9089849792F62" modified="2019-02-13" version="1">CQLVNVTDRINTSSLTMAQDRGKYDFYIGLALAVSSSIFIGGSFILKKKGLLRLARKGSTRAGQGGHAYLKEWLWWAGLLSMGAGEAANFAAYAFAPATLVTPLGALSVLVSAVLSSYFLTERLNLHGKLGCLLSILGSTTMVIHAPKEEEISSLEEMAAKLVDPGFLVFATLVIIVALIFIFVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAIAGTSVVKNPLAWILLLGLVGCVSTQINYLNKALDIFNTSLVTPIYYVFFTTSVLTCSAILFKEWEHMGADDVIGTLSGFLTIIVGIFLLHAFKDVSVSLATLAVSMRKEERAFPTANGIASHTAYELLDEKSAGDLEERDTASHFDSVSRRNGTMTSLLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BKX9</accession>
    <name>A0A3P9BKX9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">VPS50 subunit of EARP/GARPII complex</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004547985.1">
        <property type="nucleotide sequence ID" value="XM_004547928.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BKX9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010594"/>
    <dbReference type="Ensembl" id="ENSMZET00005010966.1">
        <property type="protein sequence ID" value="ENSMZEP00005010594.1"/>
        <property type="gene ID" value="ENSMZEG00005007945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463810"/>
    <dbReference type="KEGG" id="mze:101463810"/>
    <dbReference type="CTD" id="55610"/>
    <dbReference type="GeneTree" id="ENSGT00390000003442"/>
    <dbReference type="OrthoDB" id="10263345at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="7">
        <location>
            <begin position="54"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Syndetin C-terminal" evidence="6">
        <location>
            <begin position="752"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="993" mass="114065" checksum="D742B8A6ED2FDC59" modified="2019-02-13" version="1">MQKIKSLMARQGLKSPQESMADLSPVENLRIPSKEELRELREQPIDPQAEQEIIDSIEEVYFSNDSFDMVQHELEKLPPELNLQELEEYRDKLKRQQAAVSKKVADLILEKQPAYVKELERVTALQTNLQLAAVICTNARRQLSVAKEGFTEASLGLLANQRRRQLLTGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKTCKHFDVSHYTKVQLAYTLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNADTKFQKMQYKDLCTHITPDSYIPCLTDLCKALWEVMLSYHHTMQWHEEHDKQETTPTPEDAAAAESDELAVDRSYVKKKLEHGLTRIWQDVQLKVKAYILGTDMSNFKYDDFIVVLDVISRLMQVGEEFCGSKSEVLQESIKRQSVNYFKNYHRARLEELRMFLENETWELCPVKSNFNIAQLHEFKFMGQCRSPSVSPSRQAASLSSSAQEELSLFQQYQREGNPFEMHMEHKEEETEDVLASNGYESDELEKSVYQDYDSDSDVPEELKQDYVDEQTGDAPLKSVPRETMRTKKKSDYNLNKTNAPILTNTTLNVIRLVGKYMQMMNILKPIAFDVIHCVSQLFDYYLYAVYTFFGRNDMPVPSPSLQAHGSREAGTARVVGPACLYESSGLGLISSRLRTTLNRIQESLIDMEAVGENAGVHGPAEDRKEKVPSPHLSQLVVLTNSGTLYGLAQRVVATESLVFLAEQFESLQSHLDAMMPAAKKPFLQQFYSQTVSTASELRKPIYWIVAAKAIDYEQMLLMMAGVKWDIREIMSQHNVYVDVLLKEFEQFNKRLGEVSRHVRIPLPVSNVLWEHCIRLANRTLVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDLRPIPDKEFVETYIKAYYLTENDMEQFIKNHREYSMKQLANLVNVCLGSHINKKARQKLLAAIDDIDRPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BM25</accession>
    <name>A0A3P9BM25_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB (POZ) domain containing 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540652.1">
        <property type="nucleotide sequence ID" value="XM_004540595.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BM25"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010982"/>
    <dbReference type="Ensembl" id="ENSMZET00005011361.1">
        <property type="protein sequence ID" value="ENSMZEP00005010982.1"/>
        <property type="gene ID" value="ENSMZEG00005008235.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469597"/>
    <dbReference type="CTD" id="55727"/>
    <dbReference type="GeneTree" id="ENSGT00390000014092"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061138">
        <property type="term" value="P:morphogenesis of a branching epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18489">
        <property type="entry name" value="BACK_BTBD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18283">
        <property type="entry name" value="BTB1_POZ_BTBD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18284">
        <property type="entry name" value="BTB2_POZ_BTBD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042345">
        <property type="entry name" value="Btbd7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047936">
        <property type="entry name" value="BTBD7_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047934">
        <property type="entry name" value="BTBD7_BTB_POZ_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047935">
        <property type="entry name" value="BTBD7_BTB_POZ_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16064">
        <property type="entry name" value="BTB POZ DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16064:SF3">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="142"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="293"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1118" mass="123711" checksum="066831B02F524800" modified="2019-02-13" version="1">MGANGSSYPHSCSPRIGGGSQAQQTFIGTSSYSQQGYGWESKLYSLEHGHERPADRKKKSLGLATLKRRFIKRRKSSRSADHARQMRELLSGWDVRDTNALVEEYEGTAALKELSFQASLARPEAPSLQRDLAALYQHKYCTDVDLIFRGTCFPAHRAILAPRCPFFKTLLSSSPGYGAEVLMDIDTAGIDVPMFSALLHYLYTGEFGVGGAEDTRLQNVDVLVQLSEEFGTPNSLEADMKGLFDYMCYYDALLSFSSDSEMIESCNERGAVAAATSVSQGGNGAPGAAGTPDEDLRAHKAILSARSPFFRNLLQRRIRTGEEMTERTLQTPTRIVLDESIIPRKYVQVILHCMYTDVVELGLVLRGSPSAGSLGEVQALVSGSRGASTRTEEAMELYHIALFLEFSMLAQGCEDIIVESLSLDSLVPILKWSSQPYGSKWVHRQAMHFLCEEFSQVVTSDVLYELGKEHLLSAIQSDYLQASEQDILKYVVKWGEQQLIKRMADREPNLLSGTAHSVNKRGVKRRDLDVEELKEILSPLLPFIRTEHILPPNSDVLADALKRGLISTPPSDMLPTAEGGKANAWLRQKNAGIYVRPRLFSPYVEEAKSVLDEMMVEQTDLVRLRLVRMSNVPDTLYMVNNAVPQCCHMINHQQMASNSTTAPSVVANEIPVPQLSVVKEMIRRLHELRHTEQVQRAYALNCGEGATVSYELQLRVLREFGLADGATELLQNPYKFFPDERFGDESPILALRQVGRCRVNSSPAMDSMFTELEGVAGFHPPLPPPPPPYHPPATPSHAQLKGAWRPRVPLPTPTRSFSYPCNRTLIQRHAATKHGSSDYSSVPRPQPPDCTNPQAMGRALLSDQQVMSMEPVMREFMPDIALGVSVMTLREQHMAEMEREGPQSHHLPHGPCPSSRLSHGYGPGHGHSCKRHAPEPKLEAQAEFPDLYDFSCRPATPTSTHPLPSFAGPDLYSHSCTASSSYPPPYVSDSQSQGHTQGRTASDPLRLDVLSITSQRHDGLLASPSGAQPRMGHISKGRSNETDLTHGLGHLRSPSGNMDNYEERHPGPRETPEEMGLAGESSGPGPLQQPHRNSVSEEIVRDRRSPSKPDYPYKKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BMX1</accession>
    <name>A0A3P9BMX1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 385A</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004544964.1">
        <property type="nucleotide sequence ID" value="XM_004544907.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BMX1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010961"/>
    <dbReference type="Ensembl" id="ENSMZET00005011340.1">
        <property type="protein sequence ID" value="ENSMZEP00005010961.1"/>
        <property type="gene ID" value="ENSMZEG00005008223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480458"/>
    <dbReference type="KEGG" id="mze:101480458"/>
    <dbReference type="GeneTree" id="ENSGT00940000160876"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000276">
        <property type="entry name" value="zinc finger protein 385A isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000121">
        <property type="entry name" value="zinc finger protein 385B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000293">
        <property type="entry name" value="zinc finger protein 385B isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051845">
        <property type="entry name" value="Znf385"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23067">
        <property type="entry name" value="DOUBLE-STRANDED RNA-BINDING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23067:SF13">
        <property type="entry name" value="ZINC FINGER PROTEIN 385A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="427" mass="45551" checksum="2E3058F5B91CEBBD" modified="2019-02-13" version="1">MWGSGGVNRPGPVPAFLRSPPVIPPPLDMKPFLQFPLESPHPASIGLFHNFNTMDPVQKAVMTHTFGPPMMKTKRPIISCNVCQIRFNSESQAEAHYKGNRHARRVKGIETSKTTRLQDGDKQHHPPPASPSPPGPLPSSPEPDPNNNKQDDNQSCPNSKESPSTPSCLPTSTPSSADTECPLLPSVNTPLPLSPSPSAALSTPSADSAAPAAAGLLDTPSPAPSPSSGESEEEKAKKLLYCSLCKVAVNSLSQLEAHNKGTKHKTILEARSGLGPIKAYPRLGPKPSPEQGGELSSDPNTQERTFHCEICNVRVNSELQLKQHISSRRHRDGVAGKPNPLLSRHKKRTDFMELPKTLGAGLLPNPLAVAAAMAAAASSNQLALRPPGPASHPHPHHHLLQGTPLSLLRPAPGPIRTTHGPILFTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BMZ8</accession>
    <name>A0A3P9BMZ8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BMZ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010986"/>
    <dbReference type="Ensembl" id="ENSMZET00005011365.1">
        <property type="protein sequence ID" value="ENSMZEP00005010986.1"/>
        <property type="gene ID" value="ENSMZEG00005008236.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001718"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="86"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="229" mass="25718" checksum="7C88B1E0A1FCB572" modified="2019-02-13" version="1">TYPNVDVFPWLPLSDLKTAPVQGDDFSSGTSSRSTKLIHGGVRYLQKAIMKLDYKQVNASFFLRFLQLSRPLLGVTHIPLLWSCPPAAGQHNDARMNLAIALTAARYGAAIANYTEVVHLLERADPQTGKERVCGAHCRDVITGQEFDVRAKCVINATGPFTDALWKMDDQKNPDICQPSAGVHIVIPHKTPRRRRIIFYLTWGADAQTHHRIASHLWRGYQCLNYILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNS4</accession>
    <name>A0A3P9BNS4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transmembrane protein 132D</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM132 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNS4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011582"/>
    <dbReference type="Ensembl" id="ENSMZET00005011984.1">
        <property type="protein sequence ID" value="ENSMZEP00005011582.1"/>
        <property type="gene ID" value="ENSMZEG00005008673.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158942"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055422">
        <property type="entry name" value="Ig_TMEM132_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031437">
        <property type="entry name" value="Ig_TMEM132_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055423">
        <property type="entry name" value="Ig_TMEM132_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055424">
        <property type="entry name" value="Ig_TMEM132_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026307">
        <property type="entry name" value="TMEM132"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055421">
        <property type="entry name" value="TMEM132_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031436">
        <property type="entry name" value="TMEM132_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031435">
        <property type="entry name" value="TMEM132_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388">
        <property type="entry name" value="DETONATOR, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388:SF23">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 132C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23481">
        <property type="entry name" value="Ig_TMEM132_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16070">
        <property type="entry name" value="Ig_TMEM132_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23486">
        <property type="entry name" value="Ig_TMEM132_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23487">
        <property type="entry name" value="Ig_TMEM132_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23039">
        <property type="entry name" value="TMEM132_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15706">
        <property type="entry name" value="TMEM132_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15705">
        <property type="entry name" value="TMEM132_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="916"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 N-terminal" evidence="8">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 second Ig-like" evidence="12">
        <location>
            <begin position="119"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 cohesin-like" evidence="11">
        <location>
            <begin position="270"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein family 132 fourth" evidence="10">
        <location>
            <begin position="416"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 fifth" evidence="13">
        <location>
            <begin position="516"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 sixth" evidence="14">
        <location>
            <begin position="650"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 C-terminal" evidence="9">
        <location>
            <begin position="883"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="788"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1052"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="979"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1052"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120081" checksum="9365E1502120B629" modified="2019-02-13" version="1">EPGAKMSTHCSVIFNFPLSDLSSKELTDNKSPVPFPVFLPVSYEVKDADYLFLKEVGQDFMRNSSMQSHIQPFVILRASRQPVVNASYRTMSAEKPVPLDMVQSVKLFNAPEVFTFNWKIQAFVLTPRVFSSKPKVRVLFYVAGRDWNRGEGALDELPCVTVYAFWQTQEVRGSCAIGGERGTCMAELVPTPGWFAPGSEGTSRERQDPSAGNPVELYYQAQPKVRGKCNSVDGSRWGGSQQQAEFIPVTPMQRIGSVRLLQVPKGMATLSRLKLGNAIVIRTSSKPLKKTDIATFYILMASSAQLTNFTLRATVRKGVTFRTVTPSNSLLWDITLDLSVDGAIAVICQRKAPIPGKRLESSLLEVLQIDFEVEELSSPLDSQVIIWKLELPSTSKNGVKTEGAMRIYTTQRDFVGLAPLIMDTEILNTAVLTGKKVVMPVRTVAVEEDGVVTDVSDYTDCSSTDEDVLKVSDRCDYVFVNGKEVKGKIKMTVNFTYSYLSAQLELNVWMPRLPLQIEVSDTELSQIKSWRVPILTSKRTGWNSDEDDRKGKGCMLQFQHALVRVLTHFMAEQEDPRDPKAYFLGSDWQVDVTRLVRYFMKVEDTRVARLQAGRVLSGKDFGTTAIQVFSPLSDAILAKTTIRVVDDKVTITELGVQLVTGLSMTLQLSAGSNRAILATTTTQEVLQSPKQEALVSAWIQFSDGNQTPLDIYDQSFFRVTVTSLDQGVVSVQGTPPAVAAEGEGEGVLVRVEMSICEACQKSKRKSTFAVGNGTLKVKFQANTKRSDGIFDSSTVSNKETDYGNDGEEVERQRKQRKPSQDASPRINSGSPGSPTTVANVSLMSSPGENSKGYGSDNMIVEDMSSVSFTSTVKVPRNLVNSNNFPTKVETPGQGTTEIEVGGEEVLANRPLTDLEIGMYALLGVFCLAILVFLVNCVSYVVKFRHKKPPSHGQEPTGHRHDWVWLGTDAELVMSVPGSPVQQDSQTTTTVIDIGPDKTGSLSRRPSCLASVTDSPLSCVGSLRGKPMPTESLHSPTSKRKRVQFTTFSTLERQHSPHLPPRENGHGIHWVGKEDSCGEEPQVPITEPGDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQN8</accession>
    <name>A0A3P9BQN8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein RRP5 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Programmed cell death protein 11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with NF-kappa-B p50/NFKB1 and NF-kappa-B p65/RELA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_023010188.1">
        <property type="nucleotide sequence ID" value="XM_023154420.2"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005011936"/>
    <dbReference type="Ensembl" id="ENSMZET00005012345.1">
        <property type="protein sequence ID" value="ENSMZEP00005011936.1"/>
        <property type="gene ID" value="ENSMZEG00005008949.1"/>
    </dbReference>
    <dbReference type="CTD" id="22984"/>
    <dbReference type="GeneTree" id="ENSGT00390000012228"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05694">
        <property type="entry name" value="S1_Rrp5_repeat_hs2_sc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05695">
        <property type="entry name" value="S1_Rrp5_repeat_hs3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05696">
        <property type="entry name" value="S1_Rrp5_repeat_hs4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04461">
        <property type="entry name" value="S1_Rrp5_repeat_hs8_sc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000065">
        <property type="entry name" value="Programmed cell death 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000175">
        <property type="entry name" value="Programmed cell death 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000200">
        <property type="entry name" value="Programmed cell death 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000148">
        <property type="entry name" value="protein RRP5 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000340">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.162, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="281"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="455"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="544"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="633"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="726"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="1014"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="1126"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="1207"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="1301"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="1660"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1394"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1483"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1439"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1488"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1510"/>
            <end position="1520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1806" mass="201119" checksum="4074C30C8A6F533E" modified="2019-02-13" version="1">MASAVEDFPRGGTAKKSTGSKTVVHRTEADNLFQSNEQAETKKRKAGAKDDSKKLKKQKAEEKKVGLTLNAPVKCVEILHVKDVKEGMLMLGCVKEVTDFEVTVSLPSGLQGFLSIKNICDSYTKLLSEQLDSADTEEICSLPHLFYPGMVLRCVVAKLDVTKRGSLSIQLSINPKLVNKSLTPSGLKTGMVLSACVESVEDYGYIIDIGVSGTKAFLSKESLKFKHNNAQELKVGQYLTSQVEEVKNDGRVVQLSANLTTIAQTCAEPKQGWNLTTLLPGLLVKAAIKEVTKHGLILDFLSSFNGQVDFLHMEPEQASSYTKGLQVNARVLYIEPQTRLVGMSLRSHLIHLDTGIEPVPAGRERIGEVVKECKMTAMHHLSGGVLELPDKTLAFVHRNHLKESNEQTNENRVFAQPEHICRILDFSPMEQIHFATLRRSVIGKPFYRYHDVQAGQVVEGTVSVLLSHGMVVHLSDHIKGLVPRTHLSDIVLQNPEKKYMEGMKVKCRVLSVDAENKKLYLTRKKTLVESSLPLFLSYNDTRPGRVSHGYIVSVKDFGCIVRFYNGVKGLVPLSELSSEPIVRPEDIFYVGQVVKAKVLQCDPEKGKMALSFKAVVKKENEETEKPEFDCEVGKRLDAKVLKKSLNGLEVAILPDEIHAVLPMSHLSDHMSNCPLLWESLQEGDIISKLICPSKNKQNITLTKKPTVRWSLEEGVVAKDFSEITVGLQLVGWIKNIMPYGVFVEFPYGLCGLAPKSAMTDKFIRDTTNTFQVGQTVIAKVTNLDEEKRRFLVTLKISEVISPQGDAQTRLINGLQERRAVTEMLVMKDNSELQQQLAALSVGQKLKLTVDTVNDTGATFKSDALIGATILANKHHMMGVKLTNGQKVGAVVLHVDMLSACVHVSILSKVMGKKKSLAEGLKYTAMVQHIDKDFAVISLGDTAQLTVIQTCSHLNEIFLSESEKLKAGMTLSAEVIEPSCQELQGLPLVSWERSMPERKRTASENQTGRKGHCFGEILQGTVRTVKPTCIQVTLEDGSSGSVHVSEVVEPAEVRLGSFPTSSVKVGSVVTARVIGGREASSHRFLPFSHPKFTYTISELTLIPSKLNESVDFKPVTAKEKLSSYTAGEEITCFVSKFNSDRKSLEVTTDPSVSGTVELLAMTTDPKDIGHPEKLYKLGQAVRARVVEASFPPHRFVLSLTGVHKLEKGSITLGIVTNIQPQTGLLVKLPFGGMGTVAVTDLADAYRPNPLAVYNKDQFLRCYLLDNENDKWQLSLRPSRLNPDKAKPAKDPEVLSVNKLKAGQIIRGYVKSVGEQGVFIRLSRSIIGRAELQQTTKYFVKNHKIVSEHLPPNALLTTKILSIDKEEEFINLSLLPEDTGKPDVLPESLGLPLRLVREEKKKQDKKSKKRPASESEEISKKKKKESKKARTDDNDSGVEVYFREEEDKEDEGKPAKQVTSSASCPSRLQVTAGFSWDVGLSSLKPASAAQEEDSSDGEDQEGSTKPQKKSRHEQEQEKKEAEKALIQREAELMDPNLRPQDAAAFERLLLASPNSSLLWLQFMAHHLQATQIEQARTVAERALKTISFREEQEKLNVWVALLNLENMYGTEESLKKVFERAVQFCEPMPVYQKLSEIYAKSNKIKEAEGLYKTMVKRFRQNKEVWFSYGTFLLQQGQSDAASNLLQRALKSLPPKESVDVIAKFAQLEFRYGDVERGRNMFDKVLSTYPKRTDLWSVFIDLMVKHGSQKEIRALFDRVIHLSVSVKKIKFFFKRYLEYEKTHGTPQSVQAVKEKAIEFVEAKGTEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BR41</accession>
    <name>A0A3P9BR41_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAS-associated factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UBX domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004541145.1">
        <property type="nucleotide sequence ID" value="XM_004541088.5"/>
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    <dbReference type="SMR" id="A0A3P9BR41"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012096"/>
    <dbReference type="Ensembl" id="ENSMZET00005012523.1">
        <property type="protein sequence ID" value="ENSMZEP00005012096.1"/>
        <property type="gene ID" value="ENSMZEG00005009052.1"/>
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    <dbReference type="GeneID" id="101480335"/>
    <dbReference type="KEGG" id="mze:101480335"/>
    <dbReference type="CTD" id="23197"/>
    <dbReference type="GeneTree" id="ENSGT00940000157197"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
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    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="UAS_ETEA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UBA_FAF2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UBX_UBXN3B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAS-associated factor 2 isoform X2"/>
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        <property type="entry name" value="FAS-associated factor 2 isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fas-associated factor family member 2"/>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAF1_2-like_UAS"/>
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        <property type="entry name" value="UAS"/>
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    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="11">
        <location>
            <begin position="357"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="303"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="303"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRG5</accession>
    <name>A0A3P9BRG5_9CICH</name>
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        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase domain containing 2A</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547114.1">
        <property type="nucleotide sequence ID" value="XM_004547057.4"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_004547058.4"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMZET00005012960.1">
        <property type="protein sequence ID" value="ENSMZEP00005012517.1"/>
        <property type="gene ID" value="ENSMZEG00005009401.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483451"/>
    <dbReference type="KEGG" id="mze:101483451"/>
    <dbReference type="CTD" id="51011"/>
    <dbReference type="GeneTree" id="ENSGT00940000160571"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
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        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051121">
        <property type="entry name" value="FAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796:SF4">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="321" mass="35293" checksum="8A9D4F6CEA7C80AF" modified="2019-02-13" version="1">MRLPLRSFCIFRSVIAQGQAVDVQRRGLSGAAMRLVQFRRRGEEASIRVGVEQGEGHSVVDLKAFDPLMPSTMRELLELGDKGLECAQRALASGKCVVDRADIQLLSPVTGPEKVVCVGMNYRDHCLEQNAPIPKEPIIFNKFPSAITGPYDDIILPSESQEVDWEVELAFVIGRRGKHIKEEDALSYVAGFTVANDVSARDWQMKRNGKQWLLGKTFDSFCPLGPALVTTDTVTDPHNLSIRCLVNGDTVQDSNTDQIIFKTAALVAWVSKFVTLIPGDVFLTGTPPGVGAFRKPPIFLKKGDVVECQIEQLGSIINKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRV8</accession>
    <name>A0A3P9BRV8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DENN domain containing 2A</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004563873.1">
        <property type="nucleotide sequence ID" value="XM_004563816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRV8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012361"/>
    <dbReference type="Ensembl" id="ENSMZET00005012794.1">
        <property type="protein sequence ID" value="ENSMZEP00005012361.1"/>
        <property type="gene ID" value="ENSMZEG00005009300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466843"/>
    <dbReference type="KEGG" id="mze:101466843"/>
    <dbReference type="GeneTree" id="ENSGT00950000182931"/>
    <dbReference type="OrthoDB" id="10266080at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.200:FF:000001">
        <property type="entry name" value="DENN domain-containing protein 2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000004">
        <property type="entry name" value="DENN domain-containing protein 2C isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF3">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="604"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118308" checksum="2593B7B6C2375C10" modified="2019-02-13" version="1">MPAASTMTGGRALLLCTNTDNCIYQSVNGLQCCGLKLGEAPSAVVPQPKEVCGSPVDRDRRDTAVSIKNHLSPLLSPGPPDSMLAHRRATTPATDPRAPNMENGLCAKLNHNKSPAGAKTASIRDKISQWEGKKESVPVTISGTCPLSATLKEAETVRKKESKTTEVQRTDSKRFVSWDRQDSGKENVGKLGDSRPKSPEAPANKDREVMVEREFRASKPTEQPQDKKSVLTHVKKLEKATKEVPDRPSLAFPGNYFCPPSKEELEETEKRGNEPIFGTFDMARPSGTRRWRDGDSENVYNEPGAPSINPLPKPQRTFQHHTPPATPASGPFLGKGRRNLPPLPSVPPPPLPTCPPPGVCRRPWADKARNSSNRKSYEFEDLLQSSAESSQVNWYHQSRLGLTRTLSEENVYEDIIDPPSKENPYEDIELERSCLGSKCISPASSSPVPSTPNKLSSKPGFLRQNSERRSFKIPELRKTNRDTGISSPSRISPPSTPSSPDDTPCLSGDPYNRRRRKIPKMVVKINGIFEARRGKKRMKKVSQSAESSSGRVTDENSESESDTEEKLKAHSQRLVSVQSMLRQTGRYRTLERDLMELQERKLFEYFIVVALHKTKAGVPYLPEVTQQFPLKLERSFKFMRETEDQLKVIPQFCFPDAKDWAPVDNFPSETFSFVLTGEDGSRRFGYCRRLLPSGKGRRLPEVYCIVSRLGCFDLFSKILDEVEKRRAISPALVQPFMRGIMEAPFPAPGRTITVKNFLPGSGTEVIELCRPSDSRLEHVDFECLFSSLSLRLLLRVFASLLLERRVIFTADKLSTLSQCCHAVVALLYPFTWQHTYIPVLPPSMLDIVCTPTPFIVGLLSSSLPRLKELPIEEVLVVDLGNSRFLRQLDDEDSILPHKLQAALEHVLDKRRELACEKGDLPNDSSSLSTVVSEAFVRFFVEMVGHYSLFMGGTEREEESVSSTTLPSPTSSSSFQREAFRKAVTSKSLRRFLEVFMETQMFTGFIQERDLRRQGLRGLFEVRAQEYLDSLPGSEQRGVNKFLKGLGNKMKFLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSG5</accession>
    <name>A0A3P9BSG5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mos1 transposase HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSG5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012898"/>
    <dbReference type="Ensembl" id="ENSMZET00005013344.1">
        <property type="protein sequence ID" value="ENSMZEP00005012898.1"/>
        <property type="gene ID" value="ENSMZEG00005009690.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166405"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052709">
        <property type="entry name" value="Transposase-MT_Hybrid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001888">
        <property type="entry name" value="Transposase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46060:SF1">
        <property type="entry name" value="MARINER MOS1 TRANSPOSASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01359">
        <property type="entry name" value="Transposase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="40151" checksum="B389A31950327D1E" modified="2019-02-13" version="1">MTSVLLSFRCRKLRAIQVLMSDKQENNGCKESLQSNLRGSKAMSRSRCKDWYLRFKNGRTSVDDEIRSGRPSTSTTPKHIREIDQLVRQDFRISLREISAILNVSFGTVQAILTSTLNLHQVANKLVPRLLTPELKQYRLRACEDLRQQTRDDPTFMSRIITGDESWVYGCKPGKARRVNPTRSQFKVKLIVFFDIHGVVHREVVPDGQAVDAPFYLSVMTRLRKNIEAKRPELWQKGDWLLHHDDTPAHDALKECHYFCYTDTNLILHPQHSPDLAPCDFFLFPKINAKLRGHFFDTVEELQHASLIVLDSLGEEDFRRAFRAWQQRWVWCAAVQGNRFAADGGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BST8</accession>
    <name>A0A3P9BST8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Extracellular sulfatase</fullName>
            <ecNumber evidence="10">3.1.6.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="13">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus</location>
            <location evidence="1 10">Golgi stack</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_004571939.1">
        <property type="nucleotide sequence ID" value="XM_004571882.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012780335.1">
        <property type="nucleotide sequence ID" value="XM_012924881.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012780336.1">
        <property type="nucleotide sequence ID" value="XM_012924882.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BST8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013015"/>
    <dbReference type="Ensembl" id="ENSMZET00005013435.1">
        <property type="protein sequence ID" value="ENSMZEP00005012986.1"/>
        <property type="gene ID" value="ENSMZEG00005009759.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005013451.1">
        <property type="protein sequence ID" value="ENSMZEP00005013002.1"/>
        <property type="gene ID" value="ENSMZEG00005009759.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005013464.1">
        <property type="protein sequence ID" value="ENSMZEP00005013015.1"/>
        <property type="gene ID" value="ENSMZEG00005009759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478192"/>
    <dbReference type="KEGG" id="mze:101478192"/>
    <dbReference type="CTD" id="393910"/>
    <dbReference type="GeneTree" id="ENSGT00940000166926"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002063">
        <property type="term" value="P:chondrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010669">
        <property type="term" value="P:epithelial structure maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014846">
        <property type="term" value="P:esophagus smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035860">
        <property type="term" value="P:glial cell-derived neurotrophic factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032836">
        <property type="term" value="P:glomerular basement membrane development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030201">
        <property type="term" value="P:heparan sulfate proteoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060384">
        <property type="term" value="P:innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010575">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021514">
        <property type="term" value="P:ventral spinal cord interneuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000003">
        <property type="entry name" value="Extracellular sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014615">
        <property type="entry name" value="Extracellular_sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024609">
        <property type="entry name" value="Extracellular_sulfatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF4">
        <property type="entry name" value="EXTRACELLULAR SULFATASE SULF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12548">
        <property type="entry name" value="DUF3740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036665">
        <property type="entry name" value="Sulf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044535813" description="Extracellular sulfatase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="15">
        <location>
            <begin position="51"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Extracellular sulfatase C-terminal" evidence="16">
        <location>
            <begin position="544"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via 3-oxoalanine" evidence="13">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="11">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="884" mass="101824" checksum="9EBF2200B135002C" modified="2019-02-13" version="1">MAERRLSAPLPLLLFLVLVGVLPEIESSGYLSGYRLRSRLQRDRHIRNIRPNVILILTDDQDIELGSMQAMNKTRHIMEKGGTHFSNAFSTTPMCCPSRSSILTGKYVHNHHTYTNNENCSSPSWQAHHEPHTFAVHLNNSGYRTAFFGKYLNEYNGSYVPPGWKEWVALVKNSRFYNYTLCRNGVREKHSSDYTKDYLTDVITNNSIDYFRTSKRLYPHRPVLMVLSHVAPHGPEDSAPQYSSAFSNASQHITPSYNYAPNPDKHWILRYTGPMKPVHMQFTNMLQRRRMQTLLSVDDSVEKVYNMLVETGELDNTYLIYTSDHGYHIGQFGLVKGKSMPYEFDIRVPFYIRGPNVEQGAVNPHIVLNIDLAPTLLDMAGVDIPAEMDGKSILKLLDTDRPVNRFQLSRKGKTWRDSFLVERGKPPHKRADGKEMAQEENFLPKYQRVKDLCQKEEYQTSCQQPGQKWQCVEDPTGKLRLYKCKGMASLFAPRMQALMASGASQLSLTSSSDSCDCSNSGFKPSIMKRKRLLTKKKIKSSKGTSRKRWARSISFELGGDLYAVDLEKGYWPLGSRNSSWARDRRRGVNEEDNEEFSGMEVTVKPTTSNKLATPAAIKVTYRCSILMNDTVKCDGGLYKSLQAWKDHKLHIEHEIETLQTKIKNLREVKGHLKNVRPEECQCDSPSYLTTNKETFQLNAGRMLSLRMPSKQKTQWLQKEQKRRKKLRKFLKRLQNNDTCSMPGLTCFTHDNHHWQTAPFWTMGPFCACTSANNNTYWCLRTINDTHNFLFCEFATGFLEYFDLNTDPYQLINAVNTLDRNALNLMHQQLMELRGCKGHKQCSPEKGGKERNYFSEYRPVHRRKRPKVKKPSSKSLGQIWEGWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSX7</accession>
    <name>A0A3P9BSX7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSX7"/>
    <dbReference type="Ensembl" id="ENSMZET00005013165.1">
        <property type="protein sequence ID" value="ENSMZEP00005012721.1"/>
        <property type="gene ID" value="ENSMZEG00005009546.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235259"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF32">
        <property type="entry name" value="BLOODTHIRSTY-RELATED GENE FAMILY, MEMBER 16 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="59" mass="6722" checksum="7F01AD807749153F" modified="2019-02-13" version="1">TRSLLCPVCLSVFTKPVSIPCGHNFCMNCITDYWSTLSVLQCPLCKETFYTRPSEQCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BUD4</accession>
    <name>A0A3P9BUD4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BUD4"/>
    <dbReference type="Ensembl" id="ENSMZET00005014012.1">
        <property type="protein sequence ID" value="ENSMZEP00005013553.1"/>
        <property type="gene ID" value="ENSMZEG00005010192.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282517"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001594">
        <property type="entry name" value="Immunoglobulin heavy variable 9-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="123" mass="13807" checksum="12814216BB4DF26F" modified="2019-02-13" version="1">KEMGFDDFCAFVINFLFTGAGVNGQTLTESEPAVKQPGQSHRLTCTTSGFTLSSHWMHWIRQAPGKGLEWIAADTSSSTNYYSQSVQGRFTVSRDNSREQLYLQMNSLKTEDSAVYYCARDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVB7</accession>
    <name>A0A3P9BVB7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor-binding protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm. Interacts with ELOC/TCEB1, ELOB/TCEB2, TSC22D2 and TSC22D4. Interacts with the Elongin BC E3 ubiquitin ligase complex via its interaction with ELOB/TCEB2 and ELOC/TCEB1. Interacts with SALL4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
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        <property type="gene ID" value="ENSMZEG00005010213.1"/>
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    <dbReference type="KEGG" id="mze:101480427"/>
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        <property type="component" value="LG1"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
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            <end position="363"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_024803579.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9BW54"/>
    <dbReference type="Ensembl" id="ENSMZET00005014589.1">
        <property type="protein sequence ID" value="ENSMZEP00005014114.1"/>
        <property type="gene ID" value="ENSMZEG00005010637.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:112435270"/>
    <dbReference type="GeneTree" id="ENSGT01140000282516"/>
    <dbReference type="Proteomes" id="UP000265160">
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="HCARs"/>
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    <dbReference type="PANTHER" id="PTHR46048:SF10">
        <property type="entry name" value="HYDROXYCARBOXYLIC ACID RECEPTOR 1-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46048">
        <property type="entry name" value="HYDROXYCARBOXYLIC ACID RECEPTOR 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
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            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="359" mass="40465" checksum="BFD0D36A8DED3B1E" modified="2019-02-13" version="1">MTSEPNFTTASNLTTPTADGGCPPVGIGLEGKIMPPVLIIDVILGLLGNLVALWIFCFKLKAWNPNSLFLFNLVIADFLALVSLPLRIDALLRSHWVFGDGMCRINLFLMFSNRSASIALMTVVAIYRYFKVVHPHHRFNRMTKRQAVFVSLFVWLLVITPRVPMLAYNHIKGSGNTTQCFFFTSYKEASRAIIILVAMHRILTVLEFIFPMAMLLFCSIRISSFLKERRMGKPDKVRKAMRVCIAIVTVFMVCFLPTTVTTIGVWIIRSYRPWDCTSFYRFTQLSIVSLGLNFLNSALDPIIYIFSSSMFRKALVSALPCALRCGQDAEDNKTSSSGTQSTTQEEMKSMRTDRGSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWZ6</accession>
    <name>A0A3P9BWZ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Calcium load-activated calcium channel</fullName>
            <shortName evidence="15">CLAC channel</shortName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Calcium-selective channel required to prevent calcium stores from overfilling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TMCO1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552975.1">
        <property type="nucleotide sequence ID" value="XM_004552918.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWZ6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014503"/>
    <dbReference type="Ensembl" id="ENSMZET00005014986.1">
        <property type="protein sequence ID" value="ENSMZEP00005014503.1"/>
        <property type="gene ID" value="ENSMZEG00005010913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472931"/>
    <dbReference type="KEGG" id="mze:101472931"/>
    <dbReference type="CTD" id="54499"/>
    <dbReference type="GeneTree" id="ENSGT00390000002659"/>
    <dbReference type="OrthoDB" id="342726at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008559">
        <property type="entry name" value="TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917:SF0">
        <property type="entry name" value="CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917">
        <property type="entry name" value="PNAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023322">
        <property type="entry name" value="DUF841_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 15" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR023322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="188" mass="21324" checksum="04F76F2DD3CBB7C7" modified="2019-02-13" version="1">MSTMFADTILIVFISICTALLAEGITWVLVYRTEKYKRLKAEVEKQSKKLEKKKETITESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTALMGMFNSIFDGRVVAKLPFVPLSYIQGLSHRNLLGEDYTDCSFIFLYILCTMSIRQNIQKMLGLAPSRAATKQAGGFLGPPPQAAKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY96</accession>
    <name>A0A3P9BY96_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized oxidoreductase YjmC</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563910.1">
        <property type="nucleotide sequence ID" value="XM_004563853.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BY96"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014864"/>
    <dbReference type="Ensembl" id="ENSMZET00005015352.1">
        <property type="protein sequence ID" value="ENSMZEP00005014864.1"/>
        <property type="gene ID" value="ENSMZEG00005011177.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476659"/>
    <dbReference type="KEGG" id="mze:101476659"/>
    <dbReference type="GeneTree" id="ENSGT00390000007126"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="362" mass="38916" checksum="8F227F9A6B1FA427" modified="2019-02-13" version="1">MNRCLISEVEVKGFIERCMTAVGTKQHHARSLAEVLVEGDHRGHYSHGLNRMDMYVKDIQTGICAKDGEPVVEKESEATALVDGKNLLGPVVGNFCMNLAIKKANDVGIGWVVAHNSNHYGIAGYYAMQALKENMIGMSFTNTSPLVVPTRAKECTLGTNPISVAAPAKDGDSFVLDMATSAVAIGKVELHERRGDPIPEGWGCDPLGKITTDPKRVLTGGGLVPVGGSEATGGYKGYGLGMMVEVFCGILAGAQYSKYIRSWKVTDRVANLGQCFVAINPENFAPGFSDRMSDLLSIHRNLNPADLDTPVLAAGDPERMNMKKCEDMGGIPYHINVVKYMNECAKKIGVNPLLPCDKIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZE4</accession>
    <name>A0A3P9BZE4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZE4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015343"/>
    <dbReference type="Ensembl" id="ENSMZET00005015837.1">
        <property type="protein sequence ID" value="ENSMZEP00005015343.1"/>
        <property type="gene ID" value="ENSMZEG00005011520.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000272079"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF26">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="198" mass="22675" checksum="DAE5A6DCAE382FB3" modified="2019-02-13" version="1">MSNTKIITLNVKGINHVIKRRKIISLLKKDRVQIALLQETHLTDSEHLKLKRDWVGQIYYSSFTSKSRGVAILVHKNLPFTLHTIVRDTDGRFILITGLLYGELILLGSVYAPNTFDRSFYSNFLAKTSPVCPNHVIIGGDFNFDLGLFDAWRVCNPHVKDFTFFSRPHFSFSRIDYMFGVILLPTSEEEVSLVHCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZJ8</accession>
    <name>A0A3P9BZJ8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myelin protein zero-like 1 like</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_024659643.1">
        <property type="nucleotide sequence ID" value="XM_024803875.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024659644.1">
        <property type="nucleotide sequence ID" value="XM_024803876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZJ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015061"/>
    <dbReference type="Ensembl" id="ENSMZET00005015550.1">
        <property type="protein sequence ID" value="ENSMZEP00005015061.1"/>
        <property type="gene ID" value="ENSMZEG00005011307.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485354"/>
    <dbReference type="KEGG" id="mze:101485354"/>
    <dbReference type="CTD" id="555163"/>
    <dbReference type="GeneTree" id="ENSGT01030000234556"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060028">
        <property type="term" value="P:convergent extension involved in axis elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000920">
        <property type="entry name" value="Myelin_P0-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869">
        <property type="entry name" value="MYELIN P0 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869:SF19">
        <property type="entry name" value="MYELIN PROTEIN ZERO-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00213">
        <property type="entry name" value="MYELINP0"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018244045" evidence="11">
        <location>
            <begin position="32"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="265" mass="29465" checksum="C5B5B59EBA8CE6FA" modified="2019-02-13" version="1">MESKWPNTIRKRILFTGFTLCVVLVTRPTSAIEIHADPEVIVQNGTTGILRCTFRSSEVVSSATTVTWNFQSSHPDSQYYKSPYVIFYFTSGRGFPGSEEFKDRVQFIGDINKRDVSIQLSPTYFSDNGTFFCDVKNPPDVMGTQARTELRVVLKESYSQNNTTLIVAGVCGALLVLVLIAVAACIVMRVLHNRHDYEGCTSLESVNSQAPQPRKKVESRVEGSRSTSPSGPLQGPVIYAQLDHSGSKNSFHKMEPVVYADIRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZT4</accession>
    <name>A0A3P9BZT4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004558512.1">
        <property type="nucleotide sequence ID" value="XM_004558455.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZT4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015146"/>
    <dbReference type="Ensembl" id="ENSMZET00005015636.1">
        <property type="protein sequence ID" value="ENSMZEP00005015146.1"/>
        <property type="gene ID" value="ENSMZEG00005011357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473440"/>
    <dbReference type="KEGG" id="mze:101473440"/>
    <dbReference type="GeneTree" id="ENSGT00390000008063"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="360" mass="39840" checksum="3DB456D702DE0CD0" modified="2019-02-13" version="1">MADQAPSVAMEAVLKPSCDLPEDMPKIRGYDFNQGVDLHAVLKSYLTTGFQASSLALAIQEINTMIEKRLEPVEEGEGNESETPKSGCTIFLGYTSNLISSGVRESIRYLAQHKMVDVIVTTAGGVEEDLIKCLAHTYLGDFSLPGKELRLRGINRIGNLVVPNDNYCKFEDWLMPILDQMLLEQNTEGTRWTPSKMIHRLGKEINNTESVYYWAYKNNIPVFSPALTDGSLGDMIYFHSYKNPGLILDIVEDIRRLNSQAVFAKRTGMIILGGGLVKHHISNANLMRNGADYVVYVNTGQEFDGSDSGARPDEAVSWGKIRTDAKPVKVYADASLVFPLIVAETFAQHVDKLAAGKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZU5</accession>
    <name>A0A3P9BZU5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZU5"/>
    <dbReference type="Ensembl" id="ENSMZET00005015996.1">
        <property type="protein sequence ID" value="ENSMZEP00005015498.1"/>
        <property type="gene ID" value="ENSMZEG00005011628.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286915"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029495">
        <property type="entry name" value="NACHT-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14484">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01288">
        <property type="entry name" value="FISNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="78"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="799" mass="89970" checksum="9F248E098DFA10A1" modified="2025-10-08" version="2">MKKRFQCVFEGIAKAGNPTLLNQIYTELYITEGGTAGVNDEHEVRQIETASRKPDRPETTIRQEDIFKASPGRDEPIRTVLTKGVAGIGKTVLTQKYTLDWAEDKANQDIQFIFPFTFRELNVLKEEKFSLVGLVHHFFTETKEAGICSFEDFQVVFIFDGLDECRLPLDFKNPEILTDPRRSTSVDVLLMNLIRGELLPSAHLWITTRPAAANQIPPNCVDMVTEIRGFTDPQKEEYFRKRFRDKNQGKRIISHIKTSRSLHIMCHIPVFCWITATVLEDLLKTRERGQLPKTLTEMYIHFLVVQAKVKTVKYDGGAETDPHWSPESRKMIESLGKLAFDQLQKGNLIFYESDLTECGIDIRAASVYSGVFTQIFKEERGLYQDKVFCFIHLSVQEFLAALHVHLTFINSGVNLLEEQQTTNNSERREFAAKHFYQSAVDKALQSPSGNLDLVLRFLLGLSLKTGQALLRGLLTQARNGSDLGQETIAYIKKVINEEDLSAEKSINLIHCLNELNDRSLVEGIQQSLRSGSLSTYKLSPAQWSALVFILLSSEKDLDVFDLKKYSASEEALLRLLPVVKASNKALLSACNLSERSCDALSSVLSSKFSSLRELDLSNNNLRDSGVKLLSLDLLSPHCTLETLRSEIPVLILLFLIYLIAAIIESSVEFTVCFHIFCIRRLSDCNLSKRSFESLSSVLSSQSSSLRELDLSNNNVHDSGVKFLYAKLQSSLCTLEILRLSDCNLSERACATLSSVLSSKSSSLRELDLSNNNVHDSGVKLLSDGLKNPQCKVETLWSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C024</accession>
    <name>A0A3P9C024_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C024"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015583"/>
    <dbReference type="Ensembl" id="ENSMZET00005016084.1">
        <property type="protein sequence ID" value="ENSMZEP00005015583.1"/>
        <property type="gene ID" value="ENSMZEG00005011689.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159829"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052672">
        <property type="entry name" value="Type1_Cytokine_Rcpt_Type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423:SF2">
        <property type="entry name" value="INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="543" mass="60627" checksum="5DBB2D7F96A72DCB" modified="2019-02-13" version="1">MTVSSVISRCIIVLLTFSINYFPLLPVGCQRAMTTRYTGYLVVEPAPLFLMGSNLTVYCHTHKCDWRAKIYMVLNGKPVDKWERINCTTVKFYLPSIWIPLSAAICSNYMHSVVNGVDLRAGLPPDKPDTITCETAKSSSLINCSWTRGQETYLPTLYNISVNRENGSQIRLFQIQDADKITIPRSMFDENTTYLIIITASNHFGTSQSDPVVLRVKDIVIPDAPIIMQIQFPSNSVAATLQWKSNESSVYLRPHVMLRTNNTSWEMRAGVELGKNLIRVDNLTHLTEYEFQMKICNTAPVPTHTNASSISARKALLCSKWSPSVRKKSPGKGPSQQLQVWRKVERQGTDGQRNVTVLWKPLPREDFSGKVIEYDIFLDNGQKLKTCAAECIQCSVQLPAEVSSLSISAVTTYGKSPPADVILRQSGVPGSLLIKFSPAADGSAVFVSWSWTTGNYPSTQEEELRYYVIERTIVSGEGLWWQKLAKDLNSTSITGRLTTEPLGNLAVHIRTAKILPTSQLWTNDVVIAIYFYVQSTLMGTSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0X5</accession>
    <name>A0A3P9C0X5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase II subunit J</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559007.3">
        <property type="nucleotide sequence ID" value="XM_004558950.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0X5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015890"/>
    <dbReference type="Ensembl" id="ENSMZET00005016401.1">
        <property type="protein sequence ID" value="ENSMZEP00005015890.1"/>
        <property type="gene ID" value="ENSMZEG00005011932.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486043"/>
    <dbReference type="KEGG" id="mze:101486043"/>
    <dbReference type="CTD" id="5439"/>
    <dbReference type="GeneTree" id="ENSGT00550000074975"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="117" mass="13250" checksum="C59FEEB2D9F4E5ED" modified="2019-02-13" version="1">MNAPPAFESFLLFEGEKKISISKDTKVPNACLFTLNKEDHTLGNIIRAQLLKDPQVLFAGYKVPHPLEHKIVIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2T9</accession>
    <name>A0A3P9C2T9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U8 snoRNA-decapping enzyme</fullName>
            <ecNumber evidence="8">3.6.1.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">IDP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Inosine diphosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nucleoside diphosphate-linked moiety X motif 16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">m7GpppN-mRNA hydrolase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>IDP + H2O = IMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35207"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="EC" id="3.6.1.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:35208"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63714"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="EC" id="3.6.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>dIDP + H2O = dIMP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35211"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:62286"/>
            <dbReference type="EC" id="3.6.1.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:35212"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Nudix hydrolase family. NUDT16 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.64" evidence="8"/>
    <dbReference type="RefSeq" id="XP_004565511.1">
        <property type="nucleotide sequence ID" value="XM_004565454.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004565512.1">
        <property type="nucleotide sequence ID" value="XM_004565455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2T9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016419"/>
    <dbReference type="Ensembl" id="ENSMZET00005016940.1">
        <property type="protein sequence ID" value="ENSMZEP00005016419.1"/>
        <property type="gene ID" value="ENSMZEG00005012332.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005016947.1">
        <property type="protein sequence ID" value="ENSMZEP00005016426.1"/>
        <property type="gene ID" value="ENSMZEG00005012332.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466673"/>
    <dbReference type="KEGG" id="mze:101466673"/>
    <dbReference type="GeneTree" id="ENSGT00390000016224"/>
    <dbReference type="OrthoDB" id="5950381at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990003">
        <property type="term" value="F:IDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016077">
        <property type="term" value="P:sno(s)RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054754">
        <property type="entry name" value="NudT16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31699">
        <property type="entry name" value="NUDIX T16 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31699:SF1">
        <property type="entry name" value="U8 SNORNA-DECAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22327">
        <property type="entry name" value="Nudt16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="17">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="219" mass="23739" checksum="247BD95BF687451E" modified="2019-02-13" version="1">MASGQLSRAEALACSGCRHACHVMLYADTKAQLFGRIPIKHIILMQMRFDGLLGFPGGLVNPSEETLESGLSRELSEELGLALPISVEDHVDSCYAPPSSPSSSSRLITHFYVKKMDEEQIREVERAAASTAADHGLEVLGMVRVPLYTMKGGGGLASFLSHSFIGNARSQLVHSMLRLNLVAPGELHKALTHSLKTHAHTKQDLQAALALTQGLRKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3J1</accession>
    <name>A0A3P9C3J1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3J1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016692"/>
    <dbReference type="Ensembl" id="ENSMZET00005017225.1">
        <property type="protein sequence ID" value="ENSMZEP00005016692.1"/>
        <property type="gene ID" value="ENSMZEG00005012535.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234618"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000144">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="18">
        <location>
            <begin position="229"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="534" mass="60862" checksum="B6F4740F327BE222" modified="2019-02-13" version="1">MFMLCISSCFRATEEEQQAQSKKALKKQQKEAEKAAKKAEKQAKMASEQQSAEEDDFAKDRYGVSAMVQSQQKLDRELVRVQDLTPEKADQLIWLRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDRASKQMVKFAANITKESIVDVEATVRKVEQKIESCSQQDVELHVERIFVISQAEPRLPLQLEDAVRPDGEGEEEGRATVNQDTRLDNRVIDLRTTTSQAVFRLQSGVCQLFRDTLTKKGFVEIQTPKIISAASEGGANVFTVSYFKTSAFLAQSPQLYKQMCICADFDKVFCVGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVIDSITDTMVQIFKGLRDNFQTEIQTVNKQFPSEPFKFLEPTLRLEYTEAVAMLREAGVEMGDEDDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPSNPKYSNSYDMFMRGEEILSGAQRVHDAQLLTERAIHHQIDLEKIKAYIDSFRYGAPPHGGGGIGLERVCMLYLGLHNVRQTSMFPRDPKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C446</accession>
    <name>A0A3P9C446_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ (Hsp40) homolog, subfamily C, member 5 gamma b</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004540128.1">
        <property type="nucleotide sequence ID" value="XM_004540071.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C446"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016814"/>
    <dbReference type="Ensembl" id="ENSMZET00005017351.1">
        <property type="protein sequence ID" value="ENSMZEP00005016814.1"/>
        <property type="gene ID" value="ENSMZEG00005012641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481581"/>
    <dbReference type="KEGG" id="mze:101481581"/>
    <dbReference type="CTD" id="393371"/>
    <dbReference type="GeneTree" id="ENSGT00940000164252"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000017">
        <property type="entry name" value="dnaJ homolog subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051434">
        <property type="entry name" value="DnaJ_C_subfamily_member5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44027:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 5G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="219" mass="24242" checksum="7AD87E7CD4D632B6" modified="2019-02-13" version="1">MEDPNRPQRKMSTAGESLYKLLGVEKGASPDELKRAYRKMALRYHPDKNPDNPEAAEKFKEINNAHSILTDLDKRGIYDQYGSMGLSVAEQFGEEGVKYYFLMSKCWFKTLFVCCTIFTCCCCCLCCCCCCGKCKPQDEEDNFVYMDPEDLEAQIREQDAADHPVIVIQPNSSDAASHSADHPVIVIQPNSSNAAMHSGENTPIVIQTHAAKGGSGPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C548</accession>
    <name>A0A3P9C548_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004571763.1">
        <property type="nucleotide sequence ID" value="XM_004571706.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C548"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017174"/>
    <dbReference type="Ensembl" id="ENSMZET00005017719.1">
        <property type="protein sequence ID" value="ENSMZEP00005017174.1"/>
        <property type="gene ID" value="ENSMZEG00005012899.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479043"/>
    <dbReference type="KEGG" id="mze:101479043"/>
    <dbReference type="CTD" id="324048"/>
    <dbReference type="GeneTree" id="ENSGT00940000158978"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000008">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF33">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="15" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="20">
        <location>
            <begin position="193"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="20">
        <location>
            <begin position="406"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="559" mass="63417" checksum="40CFAE25FC57D6B1" modified="2019-02-13" version="1">MPKEKYDPPDPRRMYTIMSSEEAANGKKSYWAELEISGRVRSLSTALWSLTHLTALHLSDNSLSRIPPDIAKLHNLVYLDLSSNKIRSLPAELGNMVSLRELLLNNNQLRVLPFELGKLFQLQTLGLKGNPLAQEILSLYQEPDGTRRLLSYLLDNLAGAIKRMPTEQPPPRSWITLQETDRARPSALFSVMCYNVLCDKYATRQLYGYCPTWALNWEYRKKSIMQEIMGCNADIISLQEVETEQYYNFFLPELKEQGYDGFFSPKSRARTMSESDRKHVDGCAIFYRTEKFSAVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLEVRKEMMELSSGKSLHGMEKQLLLVANAHMHWDPEYSDVKLVQTMMFLSEVKSIVDKATRSLKLSSVSGETNAIPLVLCADLNSLPDSGVVEYLSTGGVDCTHKDFKELRYSDCLTKFNCNGKNSTSNGRITHGFKLKTAYENGLMPYTNYTFDFKGVIDYIFYSKPHLNVLGILGPLDHHWLVENNVSGCPHPHIPSDHFSLFAQLELLLPNLPPQVNGLHLPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C5I4</accession>
    <name>A0A3P9C5I4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C5I4"/>
    <dbReference type="Ensembl" id="ENSMZET00005018101.1">
        <property type="protein sequence ID" value="ENSMZEP00005017538.1"/>
        <property type="gene ID" value="ENSMZEG00005013199.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163299"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000004">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF22">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="90"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="8">
        <location>
            <begin position="192"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="326" mass="34671" checksum="8607FC689BD9B6B1" modified="2019-02-13" version="1">HTHTHTRSARSSCSPGKAAGLTCSGRRGAAALVQTHFVLSLMTLRFLSEPVRLVGGASRCAGTLEVRRGEWRPVAMDIWNLKDAAAVYSVRLLNGSSLCSGGLQVKSNQRWSSVCEDDFDLQDAEVVCRELGCGPPSLLQGALYGEAEAPVWSREFQCGGHESALLDCRSSGSARSSCSPGKAAGLTCSEPVRLVGGASRCAGTLEVKQRLWRSVEASGWTLTDAAVACRELDCGSAVLTGRRNASWDGPTWKIKPDCVKSGSTLRECATSSQSSTVLELICSGKRLAVSQRSLTLNESSKVQPITSLFTDLFSSQTNASDTNSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C628</accession>
    <name>A0A3P9C628_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C628"/>
    <dbReference type="Ensembl" id="ENSMZET00005018306.1">
        <property type="protein sequence ID" value="ENSMZEP00005017735.1"/>
        <property type="gene ID" value="ENSMZEG00005013331.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163520"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF102">
        <property type="entry name" value="CEREBELLIN 13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018001939" description="C1q domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="49"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="170" mass="19094" checksum="678EF717F110320B" modified="2019-02-13" version="1">MNLNSLFLILLFCEKLNSLEIKMMNIESKLENFSWDKKVKNKAEADVFGLRNTVIFSVGIGVDSPFGPFDTDVTMIYDYTFLNIGNAYSPVTGVFTAPVSGVYFNIFSHSGGRHRTWLHLYKNNEVILHIHDHQSTDTADNGENAAFLQLQQGDTVTVTTFSGFLVKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6Z9</accession>
    <name>A0A3P9C6Z9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C6Z9"/>
    <dbReference type="Ensembl" id="ENSMZET00005018643.1">
        <property type="protein sequence ID" value="ENSMZEP00005018055.1"/>
        <property type="gene ID" value="ENSMZEG00005013562.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240400"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF32">
        <property type="entry name" value="BLOODTHIRSTY-RELATED GENE FAMILY, MEMBER 16 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="344"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="185"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="543" mass="61539" checksum="02FE8DD41BA9ED94" modified="2019-02-13" version="1">FAASSPQETEMRHMSAATNLLSDDELLCPICPDVFTDPVTTPCGHNFCKKCITQHWDINFPCQCTVCKKAFPNRPQLRVNTLLSEMVAQRREAQQKAEVPCDVCTGTRLKALKSCLVCLTSYCQTHLEPHLTATSLKRHQLIEPVENLESRMCRKHDKHLELFCKTDQTCVCMLCSVLDHKAHEVVPLREEYEGKKAELEKTEAEIQQMIQKRRLKIQEIKESVKMRKDVADRQKAEGVQVLTALMESVERRLKELIKEIEDKQETTEKQAEGLIKDLEQEISELMERSSEVEQLSRSEDHLHLLQSFSSLKAASPTKDWTEVRVRPPSYEGTVGRAVETLRKDMKKLFEAAELKRVQQDAVDVTLDPDTANPYLILSDDGKQVNHGDVRKKLPDNPERFSYCVCVLAEQSFSSGRFYFEVQVKGKTDWDLGVSTESINRKGNIRLIPQNGLWTVCLRNGSEYSACAAPPVRLCLRSGPEKVGVFVDYEEGLVSFYDVDAAALIYSFTGCSFTEKLFPYFCPCTSDDGKNSAPLLITAVDHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C835</accession>
    <name>A0A3P9C835_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GTPase IMAP family member 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Immune-associated nucleotide-binding protein 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C835"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018224"/>
    <dbReference type="Ensembl" id="ENSMZET00005018815.1">
        <property type="protein sequence ID" value="ENSMZEP00005018224.1"/>
        <property type="gene ID" value="ENSMZEG00005013689.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159509"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000536">
        <property type="entry name" value="GTPase IMAP family member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF188">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AIG1-type G" evidence="16">
        <location>
            <begin position="118"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="309" mass="35123" checksum="4803752ACECA35AA" modified="2019-02-13" version="1">MFICTPDLGTPCDDISEFLSKNPHPDMCLFVVKKGFSTEQIWQQIHVLNEKTGKPTEEFKVVLPLGYEPKDFPFKSFTLEQLFNELDKVIELKQTTYTRSISSPQSEDQLDRIGKHTYTTVNVVLLGLAGTGKSASGNTILGRKHFVSKPSSNPVTTECQAEETEINDLHVRVIDTPDMFDDETEPSVRDKHVKRCKELYESELCVFVLVMHVSRFTDGERDILKKLENTFGTKVKEQTVILFTRGDDLEEADMTLEDFLHSCQPGLKEIIEKCNNRCVLFENRSSSSDQVEKLMNTVSTVLKKTAKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C962</accession>
    <name>A0A3P9C962_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mesothelin a</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mesothelin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C962"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018441"/>
    <dbReference type="Ensembl" id="ENSMZET00005019036.1">
        <property type="protein sequence ID" value="ENSMZEP00005018441.1"/>
        <property type="gene ID" value="ENSMZEG00005013848.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182957"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010335">
        <property type="entry name" value="Mesothelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026664">
        <property type="entry name" value="Stereocilin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412:SF6">
        <property type="entry name" value="MESOTHELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412">
        <property type="entry name" value="STEREOCILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06060">
        <property type="entry name" value="Mesothelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51374" checksum="9EC7886AE047FBB6" modified="2019-02-13" version="1">MLPISSQIISVNTSSVQVIQNVPNDLATEIPRSLLVGFSSSNDVITILNRKEWKPQQLTVYMCVCVCVCVCSLSSSVLQGFTCTGARNIGNGQVKNLIKACRRSGSRKVKLVESQLTCMYTYIKDDAANFNLYPPDVLLYYDYSLVPQASCRAYFTELGNADFSVFSAALSYKRTALFENAKSCLGITNTSLTKDEISVLGNMCCILDASYILNSDSSILENLKSCPSLTSAQAAAVQARITNGNTRYGYAKLWTEQTLKDLGMLPLYMSSTFYDHFNTVKRIYCLTKNCFSFCVSACTLGFITRVTIVNLTFPLNYDISQFTSCLNSTIVKDNLDALVNQVQEQNYTKIVLSKLQEAYNASGIIPEDQVQILGAMSRSATMEDINMWSIIQIDTLASLMDASNGPWDPAKAIISKYLSVKGNSLGSVELNVFRGPNLCALDVVVIRNISCVCVWRLFLHHISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9D6</accession>
    <name>A0A3P9C9D6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Solute carrier family 8 member 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014268509.2">
        <property type="nucleotide sequence ID" value="XM_014413023.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014268510.2">
        <property type="nucleotide sequence ID" value="XM_014413024.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014268511.2">
        <property type="nucleotide sequence ID" value="XM_014413025.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014268512.2">
        <property type="nucleotide sequence ID" value="XM_014413026.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9D6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018659"/>
    <dbReference type="Ensembl" id="ENSMZET00005019259.1">
        <property type="protein sequence ID" value="ENSMZEP00005018659.1"/>
        <property type="gene ID" value="ENSMZEG00005014000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487495"/>
    <dbReference type="KEGG" id="mze:101487495"/>
    <dbReference type="CTD" id="553489"/>
    <dbReference type="GeneTree" id="ENSGT00940000155129"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008016">
        <property type="term" value="P:regulation of heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000001">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000003">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2030:FF:000001">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00845">
        <property type="entry name" value="caca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF69">
        <property type="entry name" value="SODIUM CALCIUM EXCHANGER 1H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01259">
        <property type="entry name" value="NACAEXCHNGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018300808" evidence="21">
        <location>
            <begin position="32"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="394"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="523"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="965" mass="107340" checksum="C2E082695283CF43" modified="2019-02-13" version="1">MSPARTMPMFFTYKLIFFLTVISTEFPYSAAAGSTLTLTSNQTATNHSKCGGSTNCIEGVILPMWKPENPAFTDRLARATIYFVGLAYMFLGVSIIADRFMASIEVITSQERRITIKKPNGEKITTTVRIWNETVSNLTLMALGSSAPEILLSVVEVCGHNFNAGELGPNTIVGSAAFNMFVIIGLCVSVIPEGETRKVKHLRVFFITAAWSVFAYTWLYLILAVFSPGVVEIWEGLLTLFFFPLCVGLAYIADRRLLFYKYMYKRYRAGKRKGVIIETEGEPELPSKVDIEMDGKMLNSHGEEFTDGEAGFEGKELDEEEARREVARILKELKQKHPEKEMEQLMELANYQVLTQQQKSRAFYRCQATRIMTGAGNVLKKHAADQAKRATHDIFSEVSVNDFSSKVIFDPGTYQCLENCGSVALNVVRRGGDLTSTVSVDYRTEDGTANAGSDYQFTEGTVVFKPSETEKEIRIDIIDDDIFEEDEHFLVHLSNVRVTAEGSNSHEANHVDTLAGLGLPCTATVTIFDDDHAGIFTFEEPVMTVSESVGVMEVKVIRTSGARGVVVVPYKTIQGSAKGGGEDFEDTHGVLEFENDEISKTIRINIIDDEEYEKNKNFFLEIGEPRLLEMSERKAVLLQEVGGFIKTDKQLYGRDIYRKVQGREHPVPSNIISIAEDGAEEPLTKKEEEERRIAEMGRPMLGEHVKLEVIIEESYEFKSTVDKLIKKTNLALLIGTNSWREQFVEAITVSSGDDDECGEEKLPSCFDYVMHFLTIFWKLLFAFVPPTDYWNGWACFVVSITVIGMLTAVIGDLASHFGCTVGLKDSVTAVVFVALGTSVPDTFASKVAAIQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAVYHYTQGQEFKVSPGTLAFSVTLFTIFAFICIAVLIYRRRPEIGGELGGPRIPKILTTCLFFSLWLMYIVFSSLEAYCHVKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CA61</accession>
    <name>A0A3P9CA61_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Granzyme K</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014263614.2">
        <property type="nucleotide sequence ID" value="XM_014408128.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014263615.2">
        <property type="nucleotide sequence ID" value="XM_014408129.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014263616.2">
        <property type="nucleotide sequence ID" value="XM_014408130.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CA61"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018934"/>
    <dbReference type="Ensembl" id="ENSMZET00005019541.1">
        <property type="protein sequence ID" value="ENSMZEP00005018934.1"/>
        <property type="gene ID" value="ENSMZEG00005014210.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101476156"/>
    <dbReference type="GeneTree" id="ENSGT00940000163484"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF52">
        <property type="entry name" value="GRANZYME K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018099495" evidence="7">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="27"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="255" mass="28072" checksum="77CF8D70554FFE63" modified="2019-02-13" version="1">MFCLRSFGLFLSCVLLFITQPGHGSEIIQGKEVEPHSLPFMAYLRGKLSSCGGTLIHPQWVLTAAHCTRMYKVVLGAHSIRKKEKDSKQIQEVEKLFPHPNYTHVTKGNDLMLVKLQEPVTLTRAVKWLKFGNTVRDPAAGSTCLVAGWGRTETKRTSDVLKSVNVTVVDRQTCNSRDYYNHDPVITDDMICAGSDGTNVADTCQGDSGGPLLCDGALVGVTSFGRGCGVITKPGVYSFVSRKQLKWIKKTMKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CB93</accession>
    <name>A0A3P9CB93_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Speckle type BTB/POZ protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004575049.1">
        <property type="nucleotide sequence ID" value="XM_004574992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CB93"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019565"/>
    <dbReference type="Ensembl" id="ENSMZET00005020194.1">
        <property type="protein sequence ID" value="ENSMZEP00005019565.1"/>
        <property type="gene ID" value="ENSMZEG00005014681.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485540"/>
    <dbReference type="KEGG" id="mze:101485540"/>
    <dbReference type="GeneTree" id="ENSGT00940000154376"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18518">
        <property type="entry name" value="BACK_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18279">
        <property type="entry name" value="BTB_POZ_SPOP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03774">
        <property type="entry name" value="MATH_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034089">
        <property type="entry name" value="SPOP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="374" mass="42103" checksum="00684DEDF811F7BC" modified="2019-02-13" version="1">MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKAEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPDCRLADELGGLWENSRFTDCSLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTDKAPNLDKMADDLLAAADKYALERLKVMCEDALCTSLSVENAAEILILADLHSADQLKTQAVDFINYHAAEVMETAGWKSMVASHPHLVAEAYRSLASAQCPFLGPPRKRLKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGC5</accession>
    <name>A0A3P9CGC5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Complement C1q tumor necrosis factor-related protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">C1q/TNF-related protein 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homomultimer. Forms trimers, hexamers and high molecular weight oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGC5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020911"/>
    <dbReference type="Ensembl" id="ENSMZET00005021598.1">
        <property type="protein sequence ID" value="ENSMZEP00005020911.1"/>
        <property type="gene ID" value="ENSMZEG00005015697.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161832"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000020">
        <property type="entry name" value="complement C1q tumor necrosis factor-related protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF118">
        <property type="entry name" value="COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0202">Cytokine</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018043253" description="Complement C1q tumor necrosis factor-related protein 4" evidence="10">
        <location>
            <begin position="23"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="11">
        <location>
            <begin position="29"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="11">
        <location>
            <begin position="226"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00084029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="387" mass="43484" checksum="55E05231FEE3CBCD" modified="2019-02-13" version="1">MLLPAGLLIVLLCLSHMGSAWGFAHLLDDVELRSAFSVARTSSMEGGPKMTVTFDAVYVNIGGDFDAKSGLFRCRIPGAYYFSFTVGKFPHKDLSVMLMKNRNEVQAIVYEENAGEERKVQSQSVMLQLEFGDTVWLRLHGDPRYALYSNTGHYTTFNGYLVYPDVYGYQTHHHHHQQHADSEQPLQDNIPLPSDNQATDHVRPGMTDGEKEPQMKEEEEEEEDEEDDQRSAFSVGRTQSIVGVNQLGMPQHQPVSFDTAFVNIGEDFNVTEGVFTCRIPGAYYFSFNVGKMPQKTLSVKLMKNRLEVQAMIYDDSQGEKALQSQSLMLSLKPGDTVWLYSHQRDGFGAYSNHAKYITFTGFLVYPDFPAAATTNTATSQSYADKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGU4</accession>
    <name>A0A3P9CGU4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021362"/>
    <dbReference type="Ensembl" id="ENSMZET00005022067.1">
        <property type="protein sequence ID" value="ENSMZEP00005021362.1"/>
        <property type="gene ID" value="ENSMZEG00005016035.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157372"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15618">
        <property type="entry name" value="PHD1_MOZ_MORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15527">
        <property type="entry name" value="PHD2_KAT6A_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000123">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000132">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000035">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF73">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21524">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="28">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="H15" evidence="26">
        <location>
            <begin position="103"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="25">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="25">
        <location>
            <begin position="268"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="27">
        <location>
            <begin position="410"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="751"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="797"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1209"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1299"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1473"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="880"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="927"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1025"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1219"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="21">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1667" mass="186543" checksum="A808094BFF13A98C" modified="2019-02-13" version="1">MVKLANPLYTEWILEAIQKIKRQKQRPSEERICHAVATSHGLDKKTVLEQLELSVHDGSILKVTNKGSASYKDPGHPGRVGSILPANAPVPSKESIWNSSDLRHIDWNKMLRRAIEGLDDTHGSSLKNIERYLRNQDDLSDIVDNPAFRQRLRLAAKRAVNTGRLSKNGPRYKLSHGSVEGRSSRCPSASTLVLSSVTLLPHERDQLRVDPIPICSFCLGTKESNRDKRPEELLSCADCGSSGHPSCLKFSTELTSNVKRLRWQCIECKTCSSCRIQGKNADEMLFCDSCDRGFHMECCDPPLSRMPKGTWICQVCRPKENGKKLLHKKADQIKRRYAKPIGRPRNKLKQRMSVTSGDGSMVALGGRGSPGRGQKITVCSTPSSGHAASVKDARDRFARTGSRSSLMNTDSVRCPAVIEFGKYEIQTWYSSPYPPEYSRLQKLYICEFCLKYMRSKNILQRHTKKCGWFHPPANEIYRKDNLSVFEVDGNVSKLFCQNLCLLAKLFLDHKTLYYDVEPFLFYILTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQYQRQGFGRFLIDFSYLLTRQEGQAGSPEKPLSDLGRLSYLAYWKSVILEHLYKHPDKHISVKGISRATGMCPHDIAATLQQLGMIDRQDGRIVLIRRERLIQRHMEKLRANPRQIEVDPDALRWTPSTTLNAVLSEEEREAEMDAERLKEQASCWEKEEREGYMMTHSSRQPLTKVHCKVPYRTYERRPAPPWTRRIQLTEEVSDEEADDDDDDSDGSPPILTKAHAMLAAKRKRTLVLKKRGRKRKRINSSVTTETISETTEVLNEPFDNSEDERPMPLLERTFRVGEMDEEDEEEAHKDKTPAAPIKRRRGRPRLEKNRPSKPRPVKRKKGWPKGVKRGPPKWKLKNERKMGFKLNLYTPPETPMEAEQHHIHTEEAKDGPHQDGVHVDEGSKAGRGSASPNIMLDRFPSEPPSPADHGSHKSSSPEASPVASLVCSPAASPGAVSPRQVDAADSPEPPEDDQQEVQHEQKSPAKDVVHSTEGAVSLENENEENEEGEQRAQIEDQDADDEDDRHSKTAGPENNTEDLEESSKDLPKCMPTFLDAKEDNDSELSQQVSTVLCSEAEPATATESIQDKHHLPLPPAERPILNPMLREDPPVCTEIDSETAQAVQSLTQETERENVFQDCVESQEPCRNLQTYAHVSQSPQITSLDDCPQSDHSSPLSSAHSHPSQSVRSVNSPAVSILDSGYTQISPDHSAISVPSLHNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGQNSCSYGSIPPSGLPRAAAPCGMIQQNSLSSPPHCNVKSPQGCVVVERPPSNSHQQQSMTQCAIPTNFATTMQLADIPESGNPNFTLYERINHQGEYGSGHYSQSSGLSLAKLQQFTNTFIEHPHSLPFNHSASHPITSYANTPSLSSQHSSLVSLSQTPHRVPNPQVQATVTPSPNLSSPPPMMLQRNMGIPHSQRIQPQMASKNHISARSKSASLSHHQQQMYPRPPQAVAMQAPSRTLTAMPRMNMSMNIMPAPAYNVNSMNMPSLNAMNGYSMSQPMMNSGYHGNHAYMNQSPQYSMQMGMMGTQPYPQQPMQAPPHGNMVYTPAGHHGYMDTGISKQSLKGPFIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHE4</accession>
    <name>A0A3P9CHE4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hairy and enhancer of split related-7</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHE4"/>
    <dbReference type="Ensembl" id="ENSMZET00005022277.1">
        <property type="protein sequence ID" value="ENSMZEP00005021567.1"/>
        <property type="gene ID" value="ENSMZEG00005016194.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00700000104815"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="222" mass="25237" checksum="07BB64362D15A1B2" modified="2019-02-13" version="1">MKLLQEAEEATNNKKLIKSQVEKRRRDRMNRSLECLRTMLLQEPHEGSTQHRVEKAEILEHTVLFLQNNAKGDKTTGGRGDQKRSFQDGFSTCLQTASGFLGPEGKGSELGSALHAAFAARLARSHSQPEGLQSRNFLPHAKFILRMLRQKSKLKLKQAQARASGEKRLIRPYPLPLQQRFPRVPKQPQKQRESEIRAERGATKQSSAQSSPSSHTLWRPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CIU6</accession>
    <name>A0A3P9CIU6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Contactin associated protein family member 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CIU6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021934"/>
    <dbReference type="Ensembl" id="ENSMZET00005022654.1">
        <property type="protein sequence ID" value="ENSMZEP00005021934.1"/>
        <property type="gene ID" value="ENSMZEG00005004458.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160532"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000026">
        <property type="entry name" value="contactin-associated protein-like 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF84">
        <property type="entry name" value="CONTACTIN-ASSOCIATED PROTEIN-LIKE 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1180"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="13">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="133"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="319"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="495"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="16">
        <location>
            <begin position="531"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="731"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="897"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="955"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1243" mass="137935" checksum="BF545154B424E287" modified="2019-02-13" version="1">IACVRPSACIFCSSSGAGGWSPMVTDQEPWLQVDLREQMEVTAVATQGRYDSWDWVSSYLLLYSDTGRAWKQYRHEDGVGRFVGNGNLESVVQNKLSHPVRTRFLRFVPLDWNPSGWMGLRVEVYGCSYKSYVADFDGRSSLLYRFNQKSMSTVKDVISLRFKSHQAEGVLLHGEGQRGDYITLELHRGRLDLYLNLGEARFSSHRVPVTVGSLLDDQHWHSVHIERFNKQVNLTVDSYTQRFQTKGEGHSLEVDYELSFGGIPLPGKPGTFLRKNFNGCMENLYYNGINVIDLAKRRKPQIHSVGNVTFSCSQPQLVACTFVSSSSSFLSLPSASPAVGGFSVRFQFRTWNPEGLLLSVQLNPDPQQLRLQISNSWLRLTLHSSGRQKSEVSAGRRVSDGLWHSVSLDARDLQITLTVDNEPSSTIELWEQVQSRGSFYFGGCAATAPDCQGFAPAFQGCMRLIFINSQLMNLSHVQQGLLGNYNELQFDTCNIKDRCLPNLCEHGARCSQMWSSFSCDCSGTGYAGATCHNSIYESSCEAYKLSGSSSGFYFIDPDGSGPLGPTQVYCNMTEKKVWTVLSHNSTAPVTVQTSSLQKPHVMIFNYSASAKQLRAIVSGSEQRKILSCGTYYGSPLSWWLDREGEKRSYWGGFLPGVQQCSCSLEENCIDMNYFCNCDADTDTWANDTGVLSYKDHLPVSQIVIGDTDRMGSQAVYHIGPLRCYGDRSIWNAASFYQESSYLYFPTLQAELASDISFYFKTSAPSGVFLENQGLKDFIRVELSSPSVVTFSFDVGNGAAVLSVKSHVPLNDRQWHYVRAERNAKEASVQVDQLPLRFLEAPADGHLRLRLSSQLFVGGTASQQRGFLGCIRSLTANGVSFDLEERAKMTPGVSAGCPGYCTGSSSLCHNRGRCVEKSNGYICDCSQSAYGGTTCNQEVSVSFDRESSVTYTFQEPFSVMQNRSSQASTSSTDSRAREDVALSFVTSQRPAMLLTVSTFSQQYIAVILATNGSVQIWYHLQTGKKPDVFTPTPSNLADGRLHRIRIHRVGKNLYVQVSNTGTGSPFLLLKLGVEFGCVQKHFSLLGCVFVGMENFDEEVIQGASKGFIGCLSSVQFNHVAPLKVALTNRGSSLVTVRGPLVQSNCGALAESHTLQGKTSTSMTLMICLLRLTNTRADCFCVVTAVVFITVCALAVVIRLVYQQRRAQRSSGSIKEEHRHSMYTDYRTELHLHNPVRDSVKEYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLK9</accession>
    <name>A0A3P9CLK9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AT-rich interactive domain 4A</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNB3</accession>
    <name>A0A3P9CNB3_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSMZET00005024356.1">
        <property type="protein sequence ID" value="ENSMZEP00005023582.1"/>
        <property type="gene ID" value="ENSMZEG00005017648.1"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="86" mass="9548" checksum="230865D2E4024B2E" modified="2019-02-13" version="1">MKSQTAHHVSSQINTEDGDGSQGQRDLSYLDSSTPAFTNSIRHSSTRRVNHGHESDEAQVLSGEVHFISIKSKSLWELVIRQVTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPN3</accession>
    <name>A0A3P9CPN3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Retinol binding protein 4, like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 9">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPN3"/>
    <dbReference type="Ensembl" id="ENSMZET00005024786.1">
        <property type="protein sequence ID" value="ENSMZEP00005023999.1"/>
        <property type="gene ID" value="ENSMZEG00005017957.1"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00510000047107"/>
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    <dbReference type="Proteomes" id="UP000265160">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:retinol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Calycin"/>
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    </dbReference>
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        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
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        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002449">
        <property type="entry name" value="Retinol-bd/Purpurin"/>
    </dbReference>
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        <property type="entry name" value="PURPURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11873">
        <property type="entry name" value="RETINOL-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00179">
        <property type="entry name" value="LIPOCALIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01174">
        <property type="entry name" value="RETINOLBNDNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0683">Retinol-binding</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017856920" evidence="7">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="175"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="196" mass="21597" checksum="9E4011B85321C5C9" modified="2019-02-13" version="1">MGSSKLALLLVLVSCVERCLSASCVVDSFSVKEDFDPKRYAGKWYALQKKDPEGLFLQDNISAEYTIDDDGSMTASSKGRVTLFGFWVVCADMAAQYSVPDPSTPGKMFMNYQGLASYLSSGGDNYWVIDTDYDNYAITYACRTLKEDGSCEDGYALVFSRNPRGLPPAIQRVVRQKQDDICMAGEFQPVLQSGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQQ1</accession>
    <name>A0A3P9CQQ1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Si:ch73-173p19.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQQ1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024670"/>
    <dbReference type="Ensembl" id="ENSMZET00005025476.1">
        <property type="protein sequence ID" value="ENSMZEP00005024670.1"/>
        <property type="gene ID" value="ENSMZEG00005018426.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470020"/>
    <dbReference type="KEGG" id="mze:101470020"/>
    <dbReference type="GeneTree" id="ENSGT00400000022514"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="187"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="912" mass="98895" checksum="2906064EBED17C05" modified="2019-02-13" version="1">MSSSNPATIGELFLVLSEMGFTEEQIQAAMQAGHFSVAEAADWLVQGQYLRHTLVPQPSQPAGTAFSAFNPPKEAAHASESRTSPTDSRADPSLVLRSPQSCSQDPPPPVESRIKSDKSDFEEKERQRVAQEVRAERRQKKQERELVLKRIAEDRRSLQDKKQTNAAADASPPSSEGQKLGGKIQTNVDNNCILMIRLPSGESMRERFPADAPLRSVVEHITGRHPSLPSFSLLQGFPRKRFGEAELACSLRSLGLTPNAALCIQTTPPETPQETSPAGHSAEPPPCVAPPQPPPGQDMVGDQVPVIPPPLPNQLWEEAVNYAGIPGVPPLRRGSHDWGQGQRLVPGDAEDPPIDVDMDQEGEEEPLHMPNGMPRLPFFPENRMRGGFEPWQRWPGQGNRLREGPEEEAADPENAGGPLAPAAAGQAAVERLQRAAQQEDRHANQGQPSPPKRPFRAPSVPSLCALAIRATVHLMTAPSMQYSSSLAGLTPELAELLLNHMSHERLLHPRTLELFFGCPIQKFVLNSYPYSTNELLRQLRAFTALKHLSLVNSSLITDSGLCILSTLVKLQYLNLASCSKLTDSCLQHITGLKNLCFLSLDQTKVTDAGMVLYLQSVPSCLSQLSLNQTAVTETTLAVLPTSVPQLRLLSIKQTKVKDLTALAAMSSLQTLNLDGTGVTEASLEHLATHPALTSLTLVGIPVADGSHALQIISGLKLTRITLPGRHSVTDSGLSFLSGLTLLSELDLTDYTQVTDQGVSHLSTLTRLKKLSLSNTQVTDAGLPSLRCMQELQELCLDRTAVTSRGVADLITCLPHLQVLGLASTQVGDNVVRKGLIRCSQLVKLNLSRTRITDHGLKFLKQIHLAQVNLDGTGVSLMGIASLVSCTNINSIRASNTRILSPDDVSDEELEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRW2</accession>
    <name>A0A3P9CRW2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1,4 N-acetylgalactosaminyltransferase 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004572574.1">
        <property type="nucleotide sequence ID" value="XM_004572517.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012780545.1">
        <property type="nucleotide sequence ID" value="XM_012925091.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012780546.1">
        <property type="nucleotide sequence ID" value="XM_012925092.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CRW2"/>
    <dbReference type="Ensembl" id="ENSMZET00005025908.1">
        <property type="protein sequence ID" value="ENSMZEP00005025090.1"/>
        <property type="gene ID" value="ENSMZEG00005018733.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476126"/>
    <dbReference type="KEGG" id="mze:101476126"/>
    <dbReference type="GeneTree" id="ENSGT00390000006679"/>
    <dbReference type="OrthoDB" id="8920080at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008376">
        <property type="term" value="F:acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019276">
        <property type="term" value="P:UDP-N-acetylgalactosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15046:SF2">
        <property type="entry name" value="BETA-1,4 N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15046">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="241"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="479" mass="54613" checksum="33CC88E82238CA1D" modified="2019-02-13" version="1">MFFNRFQLLFAVCLMILMAFYFIDFSKYRGEPPNITPTTPERSHVSRSSVTRPLPGSCTCPQDSYILKDHLPKEQSEELKQRRAREFQLNKNRTTSVLSRLLFALPNSPLQYPIQGYTVQPLTSTVIPALGLHAEKRKSYKVVLSVSKGILTTEIQHQDVTVKGSGENKLIIESNNLVILNNLLAKVSYTSTIYHINTGDLATFQFENHEAVFPIAIKQPHIPVLYDIGTDISSQVTITTKTFLRYRELKVLLDSIRKFYNNIKVIIADDSLEPEPIHRENILYYIMPPAQGWFAGRNLAVSQVTTKYFLWVDDDFVFTEKTKIEKLVEVMEANPELDVVGGAVEENQFYFTLIYEEGKENEGGCLYRKSQGKFHSLPGYPQCFLTNGVVNFFLARTDAVQKVGFDPKLQRVAHSEFFMDGLGSLLVASCSHVSIGHQPKTANSQSSIYDKYRHPGENDEEFKLQLHFYKNNLKCITYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CTW2</accession>
    <name>A0A3P9CTW2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CTW2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025768"/>
    <dbReference type="Ensembl" id="ENSMZET00005026602.1">
        <property type="protein sequence ID" value="ENSMZEP00005025768.1"/>
        <property type="gene ID" value="ENSMZEG00005019225.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177343"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052958">
        <property type="entry name" value="IFN-induced_PKR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289">
        <property type="entry name" value="52 KDA REPRESSOR OF THE INHIBITOR OF THE PROTEIN KINASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46289:SF14">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="148" mass="17179" checksum="67E09D2A860375BD" modified="2019-02-13" version="1">MEGIQACNPSSPTFLSKDALKPIAAHYHVTIKPEELVVAKNFMKRKMEKENICDITTAFHLLDEDMFPTLKVIFRIALTIPVSSCSCERSFSALRRLHMWLRRTMGQERLNDLAILSIEKYLDNVDPENVIDRFAKLKPRRYNLMLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYE6</accession>
    <name>A0A3P9CYE6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Virion membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CYE6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027375"/>
    <dbReference type="Ensembl" id="ENSMZET00005028248.1">
        <property type="protein sequence ID" value="ENSMZEP00005027375.1"/>
        <property type="gene ID" value="ENSMZEG00005020418.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064449"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF81">
        <property type="entry name" value="ERVV2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="7" id="KW-1043">Host membrane</keyword>
    <keyword evidence="5" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="470" mass="52138" checksum="DED0E6B0DB8545B2" modified="2019-02-13" version="1">MTRIQESTASRPDLEQTPIPDSATVYVDGSCSRPNDNSFLFNSWYENARTAARDLGNSNCYVCSKGNPEQVIVGYPISDNALLKDTLQLTLSPLDCLLRHAHTPTNPETPLGELLKLSNDTAGTCAPMKRPKNRLKPSLPLGQIPFHFNTSMICLRRLKLTGPDTHIDYTKDNYTFFSDSPGARCNETWLAVSVAEVLSYLEEHTHSSSSSGESIIVPPEGVLNDTDSGELVKSHMVTCLTRAIPNGYWMCNNTLRLALPVNWTGTCGLVTLAQELLIQQTSDLPVSSRRTKRSAYSHNVYIDAIGVPRGIPKELKAQGEISAGFASILPWIQVNKNVAWINYVYYHQQRHTNLTNTALKALEEQMSATSLMTMQNRMALDMLLAEKGGVCAMFRDVCCTFIPNNTAPNGSFTQAMNRLEALQIELRANAGHGQWLDKWLQDTFGKWKELIVAFVTVAACIILFLMIIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZZ5</accession>
    <name>A0A3P9CZZ5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Orthodenticle homeobox 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004540687.1">
        <property type="nucleotide sequence ID" value="XM_004540630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZZ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027674"/>
    <dbReference type="Ensembl" id="ENSMZET00005028553.1">
        <property type="protein sequence ID" value="ENSMZEP00005027674.1"/>
        <property type="gene ID" value="ENSMZEG00005020638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479186"/>
    <dbReference type="KEGG" id="mze:101479186"/>
    <dbReference type="CTD" id="30501"/>
    <dbReference type="GeneTree" id="ENSGT00940000155014"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097306">
        <property type="term" value="P:cellular response to alcohol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030917">
        <property type="term" value="P:midbrain-hindbrain boundary development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003406">
        <property type="term" value="P:retinal pigment epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000142">
        <property type="entry name" value="homeobox protein OTX2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003022">
        <property type="entry name" value="Otx2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003025">
        <property type="entry name" value="Otx_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013851">
        <property type="entry name" value="Otx_TF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45793:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN OTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03529">
        <property type="entry name" value="TF_Otx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01257">
        <property type="entry name" value="OTX2HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01255">
        <property type="entry name" value="OTXHOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="290" mass="31772" checksum="3332186C3648FEFE" modified="2019-02-13" version="1">MMSYLKQPPYTVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKSSPTREVSSESGASGQFTPPTSTTTVPAISTSTAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLSGPGSTLSPMSTNAVTSHLNQSPASLSTQGYGTSGLGFNSTADCLDYKDQAASWKLNFNADCLDYKDQTSSWKFQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2H5</accession>
    <name>A0A3P9D2H5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Adenylate kinase isoenzyme 6</fullName>
            <shortName evidence="9">AK6</shortName>
            <ecNumber evidence="9">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coilin-interacting nuclear ATPase protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="9">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AK6</name>
        <name evidence="9" type="synonym">CINAP</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11. Interacts with COIL (via C-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Cajal body</location>
        </subcellularLocation>
        <text evidence="9">Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="9"/>
    <dbReference type="RefSeq" id="XP_004558684.1">
        <property type="nucleotide sequence ID" value="XM_004558627.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012776601.1">
        <property type="nucleotide sequence ID" value="XM_012921147.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D2H5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028554"/>
    <dbReference type="Ensembl" id="ENSMZET00005029459.1">
        <property type="protein sequence ID" value="ENSMZEP00005028554.1"/>
        <property type="gene ID" value="ENSMZEG00005021300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474230"/>
    <dbReference type="KEGG" id="mze:101474230"/>
    <dbReference type="CTD" id="102157402"/>
    <dbReference type="GeneTree" id="ENSGT00390000015930"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003001">
        <property type="entry name" value="Adenylate kinase isoenzyme 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="174" mass="20151" checksum="A4EEA4A9084F2375" modified="2019-02-13" version="1">MKTKKQPNILLTGTPGVGKTTLGKELAQRTGLTYVNIGDLAQEGQLFDGYDDEYQCPILDEDRVVDELDEKMSEGGVIVDYHGCDLFPERWFDIVFVLRTDNTQLYTRLEARGYTGKKLQDNVQCEIFQTIYEEAMEAYSKEIVHQLPSNTPEDMEHNLEQIVHWTEQWMKDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3H4</accession>
    <name>A0A3P9D3H4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase MYCBP2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3H4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029175"/>
    <dbReference type="Ensembl" id="ENSMZET00005030093.1">
        <property type="protein sequence ID" value="ENSMZEP00005029175.1"/>
        <property type="gene ID" value="ENSMZEG00005021747.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155756"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008582">
        <property type="term" value="P:regulation of synaptic assembly at neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45943:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41107" checksum="EF64835650BE480D" modified="2019-02-13" version="1">MGLGLLLSGRALAERYRRIYTTAINDKEQGINQGRGKKALSKKKLKRRQKVKSKVKSRTKVRDGALCVPDIKLHSNPSAFNVYCNVRHCVLDWQQREASLALASRSSVQSGDSDSEEEEEYREPAVKLPKIIGIGLCGVFELIKETRFSHPLLCLRSLQALLDMLQGQQPEGFQTEPPDVLESLFQLLLETTVRSTGPNDPTGQAITALSCACLFSLVVAWGDTGKILQAVSAILTNNGSHACQTIQVPTILNALQRSVQAVLVGKIQIQDWFGNGIKRAALMNKWVLKEVTIDEDERCLLQTDGSFLYLLCKDGLYKVGSGYSGTVRGHVYNSTSRIRNRKEKRSWLGFAQVSNANIDMYTFFLHFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D470</accession>
    <name>A0A3P9D470_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cystatin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Stefin-B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546779.1">
        <property type="nucleotide sequence ID" value="XM_004546722.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D470"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029435"/>
    <dbReference type="Ensembl" id="ENSMZET00005030363.1">
        <property type="protein sequence ID" value="ENSMZEP00005029435.1"/>
        <property type="gene ID" value="ENSMZEG00005021960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466789"/>
    <dbReference type="GeneTree" id="ENSGT00940000167204"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071220">
        <property type="term" value="P:cellular response to bacterial lipoprotein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000001">
        <property type="entry name" value="Cystatin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001713">
        <property type="entry name" value="Prot_inh_stefin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414:SF21">
        <property type="entry name" value="CYSTATIN 14A, TANDEM DUPLICATE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11414">
        <property type="entry name" value="CYSTATIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00295">
        <property type="entry name" value="STEFINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="domain" description="Cystatin" evidence="9">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="99" mass="11196" checksum="E2A97F5ECC091502" modified="2019-02-13" version="1">MPMCGGLTDVKQADEEVQKICDTMKPHAEQKTGRNFEVFTAKNYKTQVVAGTNYFIKVHVGGDECVHLRVYKKLPCYGGELELSSVQHPKSHDDSIEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6C7</accession>
    <name>A0A3P9D6C7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKRD34 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553245.1">
        <property type="nucleotide sequence ID" value="XM_004553188.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6C7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029894"/>
    <dbReference type="Ensembl" id="ENSMZET00005030834.1">
        <property type="protein sequence ID" value="ENSMZEP00005029894.1"/>
        <property type="gene ID" value="ENSMZEG00005022298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468801"/>
    <dbReference type="KEGG" id="mze:101468801"/>
    <dbReference type="CTD" id="390616"/>
    <dbReference type="GeneTree" id="ENSGT00390000012355"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042637">
        <property type="entry name" value="AN34A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24156:SF6">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 34C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="529" mass="57246" checksum="E0E3E8FA596A80B9" modified="2019-02-13" version="1">MADILELRTDGNSLLKAVWLRRLRLTRLLLEGGAYINESNERGETPLMVACMSTHTDQQSVSKAKLVKYLLDNQADPNIQDKGGRTALMHACIHKAGHKVVDHLLSNGADPSLEDRSGASALVYAINADDKETLKLLLDACKAKGKEVIIITTDKSPSGTKTTKQYLNVPPSPELVERSSPAYCTSPSDINVTASPSPEQEQQNTVFSFQTKLKTSSSASKLANGPTSPTRRPANPKRARLPQLKRLQSEPWGLIAPSVLAAAAAAAHDESKKASSDEDVVAGVNGLSLSKRSALSRQNSVDGKDSLFPLVGEQPCKMTTSLSVPPTSKPSYERTLGQHQPLARRSTVPTEQESSSCSSGLASLRDTMHRRHLGNDHYDSDSQLYSDSAMLDSPKVPVERRKLNTSPLVMLTSSRESLDSNASTSSPSTARRRAPGLLERRGSGTLLLDHISHTRPGHLPPLNINPNPPIPDIGASNKPSSPLATGIRSIAPVAPNTPKRGGLKLKKKLVRRHSMQVEQMKQLSDFEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7V7</accession>
    <name>A0A3P9D7V7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004553174.1">
        <property type="nucleotide sequence ID" value="XM_004553117.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7V7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030186"/>
    <dbReference type="Ensembl" id="ENSMZET00005031135.1">
        <property type="protein sequence ID" value="ENSMZEP00005030186.1"/>
        <property type="gene ID" value="ENSMZEG00005022504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474766"/>
    <dbReference type="KEGG" id="mze:101474766"/>
    <dbReference type="CTD" id="556756"/>
    <dbReference type="GeneTree" id="ENSGT00940000153424"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000110">
        <property type="entry name" value="Death-associated kinase 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000250">
        <property type="entry name" value="Death-associated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF15">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="365" mass="42099" checksum="EB61612FBC3D8740" modified="2019-02-13" version="1">MRTPGMAVFKQENVEDFYEIGETLGSGQFAIVKRCIEKSTGNKYAAKFIKKRLSGASRRGVKREEIAREVDILQQLQHPNIVALHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATQFIKQVLHGVQFLHSKKIAHFDLKPENIMLLDRDATLPRIKIIDFGLAHKIQDGTDFKNIFGTPEFVAPEIVNYEQLGLEADMWSIGVITYILLSGASPFLGDTKQETLANISAVNYEFDEEFFSSTSELAKNFIRGLLEKETRKRMTIEDALNHPWIKPLNPRQALVKRLSVVNLENFKRQYARRRWKLSFRIVALCNHLTRIMKNHKNEKLPEEDGRNCESDQEEETMKRRPRTRKRSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8F4</accession>
    <name>A0A3P9D8F4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004552321.1">
        <property type="nucleotide sequence ID" value="XM_004552264.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004552322.1">
        <property type="nucleotide sequence ID" value="XM_004552265.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8F4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030386"/>
    <dbReference type="Ensembl" id="ENSMZET00005031339.1">
        <property type="protein sequence ID" value="ENSMZEP00005030386.1"/>
        <property type="gene ID" value="ENSMZEG00005022641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474304"/>
    <dbReference type="KEGG" id="mze:101474304"/>
    <dbReference type="CTD" id="2145"/>
    <dbReference type="GeneTree" id="ENSGT00940000156604"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
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    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="523"/>
            <end position="625"/>
        </location>
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        <location>
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            <begin position="1"/>
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            <begin position="200"/>
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        </location>
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        <location>
            <begin position="386"/>
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        </location>
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            <begin position="220"/>
            <end position="241"/>
        </location>
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            <begin position="425"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9A0</accession>
    <name>A0A3P9D9A0_9CICH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="common">zebra mbuna</name>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005023228.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="64" mass="7448" checksum="F1960579D494AA99" modified="2019-02-13" version="1">NRILKSSLESQNANGFYEVTLLNTQKSSKQKLEELNHMADKWEKSLSLTQKDQLQKKSVVEVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9B2</accession>
    <name>A0A3P9D9B2_9CICH</name>
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            <fullName evidence="14">Homeobox B4a</fullName>
        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
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                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
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                <person name="Greuter L."/>
                <person name="Guyon R."/>
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                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
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                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
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                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Ron M."/>
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                <person name="Venkatesh B."/>
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                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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                <person name="Di Palma F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Antp homeobox family. Deformed subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004568690.1">
        <property type="nucleotide sequence ID" value="XM_004568633.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9B2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030944"/>
    <dbReference type="Ensembl" id="ENSMZET00005031936.1">
        <property type="protein sequence ID" value="ENSMZEP00005030944.1"/>
        <property type="gene ID" value="ENSMZEG00005023060.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485691"/>
    <dbReference type="KEGG" id="mze:101485691"/>
    <dbReference type="CTD" id="30340"/>
    <dbReference type="GeneTree" id="ENSGT00940000162072"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000029">
        <property type="entry name" value="Homeobox protein Hox-D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="167"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="258" mass="29461" checksum="1B31033DA787C8C0" modified="2019-02-13" version="1">MAMSSYLINSNYVDPKFPPCEEYSQSDYLPSHSPDYYSSQREEPAPFQPDSLYHHHQHHPHQNHSQQQRAEPPYTQCQRGSQTASVVMSPRGHVVAPTGLQTTPLPEQSHRCDSVTPSPPPPPSCGQTPHSQSSSSPTSTRKDPVVYPWMKKVHVNIVSSNYTGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHTLCLSERQIKIWFQNRRMKWKKDHKMPNTKVRSGTGSNNTNSQALAGSQSRSSGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAX0</accession>
    <name>A0A3P9DAX0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pannexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PANX</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Structural component of the gap junctions and the hemichannels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAX0"/>
    <dbReference type="GlyCosmos" id="A0A3P9DAX0">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005032873.1">
        <property type="protein sequence ID" value="ENSMZEP00005031840.1"/>
        <property type="gene ID" value="ENSMZEG00005023749.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101487320"/>
    <dbReference type="GeneTree" id="ENSGT00940000153972"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022829">
        <property type="term" value="F:wide pore channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904888">
        <property type="term" value="P:cranial skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032732">
        <property type="term" value="P:positive regulation of interleukin-1 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039099">
        <property type="entry name" value="Pannexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15759">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15759:SF3">
        <property type="entry name" value="PANNEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="12">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600990-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="450" mass="51499" checksum="9222FE974B57A888" modified="2019-02-13" version="1">MSIAQAAAKAMLSDALLRDDSGIHRISHLELELPLDKVIKFVSVGLPLMLVCMAFAREISLGPQISCFPPSNFTVKQASYIDTYCWDSLMHHEFDSDGNFEERSLWVHKMFPYSLLAMAVLMYLPALLWRQLVMPTLGSDLLFIIDELDKSYNRSVRMAQNILDMRQNTKNPLTFQAELQRAKKKRYFEYPLLERHMQCKQNSYFLVSMLFLRGFLLLIFMTAACLYLAYFHLSAFLQDEFSCFVRTGMLRDQNWIPELVQCKMIGQLVFQVISVANGAIYILLAPIVLFSLLRLFVWDTTFISIYEVLPALDLINRRRLGCPLNDLNVLLLFLRANIAHLKSYGQVRALCSLAPPQVGNTTAQQGLHAMLTQEEIEEREEAAKELAEEVGEAREEGKLNLVDIMTILGAAQGRVVNCNEKRPLVEENMSLEPNHQGYHELKETAPFSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DBS4</accession>
    <name>A0A3P9DBS4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DBS4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031983"/>
    <dbReference type="Ensembl" id="ENSMZET00005033017.1">
        <property type="protein sequence ID" value="ENSMZEP00005031983.1"/>
        <property type="gene ID" value="ENSMZEG00005023854.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157340"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF14">
        <property type="entry name" value="TRIO AND F-ACTIN-BINDING PROTEIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="376" mass="42872" checksum="E09D6B7B7FF3956C" modified="2019-02-13" version="1">MSRLDEHGKWRKHWFVLRDTSLRYYRDSEAKESDDLDGEIDLTSCVNVSDCDVDKNYGLQIQTKGAVFTLSAVTSRIRKNWLKLLKQAIQNNTHQSDIGSEKENPLSRRPSPCQPPAQFTCKDSGYEPATCTSTTRAANSYQTEIHHQAADRDLGADLSLASQREEGECWDREQAKRLEERNKWFEEGLPVNEMGSRWESMELKKGSVPVPVIETMDSEVNRKWVEFETMSFQDMSSQSLIGTQAYQSSTAQASASLLTPQRDHSPPQEVNQSVTGSQTDTSNMKEAPPSINGAQITMNTAEALQKEVGENFQFKKSDAQSQGKKIILLSNRDRDFSLFFHLLPLYPYTFSIKQSSRLFFFESRWRALRGSVRPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DC18</accession>
    <name>A0A3P9DC18_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DC18"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031909"/>
    <dbReference type="Ensembl" id="ENSMZET00005032943.1">
        <property type="protein sequence ID" value="ENSMZEP00005031909.1"/>
        <property type="gene ID" value="ENSMZEG00005023803.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286933"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF129">
        <property type="entry name" value="TRANSPOSABLE ELEMENT TC3 TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="140"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="338" mass="38569" checksum="1E5577E5BECE5708" modified="2019-02-13" version="1">MGQKKDLTGSEKSKIVRYLAEGCSSLKIAKLLKRDHRTIKRFIQNSQQGRKKRVEKPRRKITAHELRKVKRAAAKMPLATSLAIFQSCNITGVPKSTRCAILRDMAKVRKAERRPPLNKTHKLKRQDWAKKYLKTGFSKVLWTDEMRVSLDGPDGWARGWIGKGQRAPVRLRRQQGGGGVLVWAGIIKDELVGPFRVEDGVKLNSQSYCQFLEDTFFKQWYRKKSASFKKNMIFMQDNAPSHASKYSTAWLARKGIKEEKLMTWPPCSPDLNPIENLWSIIKCEIYKEGKQYTSLNSVWEAVVAAARNVDGEQIKTLTESMDGRLLSVLAKKGGYIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCA4</accession>
    <name>A0A3P9DCA4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gypsy retrotransposon integrase-like protein 1</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCA4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031999"/>
    <dbReference type="Ensembl" id="ENSMZET00005033033.1">
        <property type="protein sequence ID" value="ENSMZEP00005031999.1"/>
        <property type="gene ID" value="ENSMZEG00005023862.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263500"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000004">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="6">
        <location>
            <begin position="397"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123153" checksum="95F3E94168147942" modified="2019-02-13" version="1">MKILDVASVVGQTEAVAAHQRPVNKDATPKLSAALNQCNVRKHLSKVSPKLIGTKSTCQVMIQDKQFNCLMDTGSQVTTVTKSFFDQHLFKTQIEPLYDLLEVEGANGLPVPYLGYIKITITFPEQFLGKECDVPTLALVVPDSGTSGFHVLIGTNTLDVAYNMHKEKGPVIHHPSADGYKTVLKVLQLRHEQCHDSNIGVVRMHGKDKKVVPAGETVVLEGTVAVKGLQSEKCAIVEYPTSSLPGGLLVKTCLLNIPTRSPCRLPVVISNASEHDITIPAKSVIAELNAIQAILPHKQSAMEGQEPTKLPGSKSPDQPKLVFDFGESHISPEWRDRIVEKLNGLPEVFAMNDIDFGRTDKVKHHIKLSDQTPFKHRARPIHPNDLEAVRKHLQELLDAGVIRESESPFSSPIVVVRKKNGQVRLCIDYRKLNLQTVKDAYALPRMDNTFTALSGSRWFSVLDLKSGYYQIEVDEADKPKTAFVCPLGFWEFNRMPQGVTNAPSTFQRLMEKCMGDMNLKEVVVFLDDLIVFSKTLEEHEARLIKVLNRLKEYGLKLSPEKCKFFQSSVRYLGHVVSERGVETDPEKIAALRTWPVPHRLKELRAFLGFCGYYRKFIKGYSSIVKPLNDLTSGYPPVQKHSKSKDKSGQYYHPKEPFLDRWTPACQQAFEMIIDKLTTSPVLAFADPTLPYILHTDASSTGLGAALYQEQEGQLRVVAYASRGLSRSESRYPAHKLEFLALKWSVTEKFSDYLYGNQFTVVTDSNPLTYILTSAKLDATSYRWLAALSTFSFKLQYRPGKQNGDADALSRRPHGNLRDDLPSQKEWDRIRRFTQHHLSDPGDIEVVNPEVVQAICERQLIYCTDNAMDCDGSISLVESLAISADAVPDSFGHEDGLGGLPIIPNLSEEDLRDKQRADQCIKHVISQIEHGVKPPSSLRTELPDLPLLLRELNKFELRNGILYRTRLEEGHPQHQLVLPEELRDVVLTSLHDDMGHTGKERTVDLVRARFYWPRMALDIEKKIRTCTRCVCRKALPERAAPLVNITTTRPLELVCMDFLSVEPDRSNTKDILVITDHFTKYAVAGPTQNQKARTVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DD46</accession>
    <name>A0A3P9DD46_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sprouty related EVH1 domain containing 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DD46"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032428"/>
    <dbReference type="Ensembl" id="ENSMZET00005033473.1">
        <property type="protein sequence ID" value="ENSMZEP00005032428.1"/>
        <property type="gene ID" value="ENSMZEG00005024156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161445"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10574">
        <property type="entry name" value="EVH1_SPRED-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000052">
        <property type="entry name" value="Sprouty-related, EVH1 domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023337">
        <property type="entry name" value="KBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041937">
        <property type="entry name" value="SPRE_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF19">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51488">
        <property type="entry name" value="KBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="KBD" evidence="6">
        <location>
            <begin position="232"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="521" mass="55286" checksum="65B6C98E309921EF" modified="2019-02-13" version="1">MEGVRVRAVVMTRDDSSGGWVPLGGGGLSHVVICKGRSHDGRGRREYIIRGERLRDRAPVLECAVQKGLVYNKVNPIFHHWRVEDRKFGLTFQSPADAISFEKGLQTVIDKLDRSDSPSSSTPEEADTEDDGQASHTGSESSSNSRKEMLPKPITIVTSESSSTCFVRSEEFSFGSSHAVTTQTPAQIHTRSGQHQLSQMTAVLNPPAPPPPPPAPPTPPVGPPASSPLSPLSPTISLLEEGDLHSVDPCKDLWGSRGYEDYRRAGATRTMVGGLTGGVVVGGGGSLQDKSELCVVRFEKELAGVGSAGCDVTVSLDSKASQRLSSSSPICMSMPNAVSGVSSGAGSPQETGKGSPSPCCIHTSLATPRSRTRKRGGGASSSGDPGAISPDDDSPCPQASSSCSSRCVYCRSVFSASENGRGRCRDAPDPALHCLRQWTCVWCAESLLYHCMSDSEGEFWEPCSCDDSMGGHPHPLCCARWLALLALSLFVPCMCCYLPLRACLRCGERCGCCGGKHKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DI09</accession>
    <name>A0A3P9DI09_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004550300.2">
        <property type="nucleotide sequence ID" value="XM_004550243.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DI09"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033771"/>
    <dbReference type="Ensembl" id="ENSMZET00005034957.1">
        <property type="protein sequence ID" value="ENSMZEP00005033771.1"/>
        <property type="gene ID" value="ENSMZEG00005025249.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183122"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000015">
        <property type="entry name" value="argininosuccinate lyase isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000014">
        <property type="entry name" value="Os03g0824900 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="10">
        <location>
            <begin position="369"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="465" mass="51638" checksum="81451CC56D770C27" modified="2019-02-13" version="1">MASTEGSKLWGGRFVGDTDPIMEKFNASIAYDQRMWDADIRGSKAYVKALERAKLVSTDEMEQILHGMAQISDEWSRGVFVIKPGDEDIHTANERRLKELIGAPAGKLHTGRSRNDQVVTDMRLWLGSAISTLTDNALQLITTMVERAAAEIEVLFPGYTHMQRAQPIRWSHWILSHAVALSRDVERLQELKKRVNVLPLGSGAIAGTPFDIDRELLQRELGFDSISLNSMDATGQRDFVAEFLFWASLCLTHLSKMAEDLILYSTKEFSFITLSDAYSTGSSLMPQKKNADSLELIRSKAGRAFGRCAGFMMTLKSLPSTYNKDLQEDKEAMFDCYDNVQAVLQVTTGVMSTLKINQTVMEAALSPDMLATDLAYYLVRKGVPFREAHGLSGKAVFTAESKNIALNQLTVEDLTAISPLFGSDVSSVWDYRSSVEQYSAPGGTAKSSVAAQVEHLRNWLKKHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIA3</accession>
    <name>A0A3P9DIA3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zgc:110366</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIA3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034138"/>
    <dbReference type="Ensembl" id="ENSMZET00005035336.1">
        <property type="protein sequence ID" value="ENSMZEP00005034138.1"/>
        <property type="gene ID" value="ENSMZEG00005025516.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164809"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19135">
        <property type="entry name" value="AKR_CeZK1290-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF10">
        <property type="entry name" value="ZGC:110366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="109"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="251" mass="27950" checksum="D09FE769A9D3CC88" modified="2019-02-13" version="1">MPLASVLNCPTVPLSNGLQIPVLGLGTSHNGGYSHDAVMYALTECGICHIDTAKRYGCEAELGKAVRESGLPRSDLWLTNKLWPGDYGYTAAKKACLDSCLEMGVEYFGVCRAIGVSNFLVHHLEQLKEDCTVIPHVNQVEYHPFQQPNHLIQYCRQEGIVFEGYSPLAKGQVFNNPTVLQIAEKHRRTPAQICIRWSIQNGVVTIPKSTKKKRIQENCEVFGFQLEDEDMAALGSLHDGRHVTWDPTNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK73</accession>
    <name>A0A3P9DK73_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DK73"/>
    <dbReference type="Ensembl" id="ENSMZET00005035769.1">
        <property type="protein sequence ID" value="ENSMZEP00005034556.1"/>
        <property type="gene ID" value="ENSMZEG00005025812.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="95" mass="10643" checksum="BDF086FA5392A904" modified="2019-02-13" version="1">MLSLGHRVMLSLGHRVIVVPGTSCNVVPGHRVMLSLGHRVIVVPGHRVIVVPGTSKRLRWRVDLVTCEPPTSTGWELMWSACRHGTENYSFNLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLF5</accession>
    <name>A0A3P9DLF5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Testis specific protein Y-linked</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546408.1">
        <property type="nucleotide sequence ID" value="XM_004546351.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLF5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035229"/>
    <dbReference type="Ensembl" id="ENSMZET00005036476.1">
        <property type="protein sequence ID" value="ENSMZEP00005035229.1"/>
        <property type="gene ID" value="ENSMZEG00005026330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466112"/>
    <dbReference type="KEGG" id="mze:101466112"/>
    <dbReference type="CTD" id="337214"/>
    <dbReference type="GeneTree" id="ENSGT00940000166378"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="554" mass="60226" checksum="FB324C53D82ECA53" modified="2019-02-13" version="1">MSEVMDCKQSADSASRKRCPSPDKDEGSLIPSKSAKLSDQPDETRVSSESCKDSEAESKEAAGSEGQSKDGKEEQAAVKADQGSEGAGGTSSQPVNSSSADSHHTSSSTDKPQSSDQQESAHAKDKAEKTVETERRPTAPLDKSDSAAIAAAEALASLTGGDGEDSQETPCSSEKAKQVKQGSKFKQRGGHQSSKVGSKTQAAAADSSTSVHSTDREDTDDVPEADEGDESVSGSSSTPSSSFPSENEENDDGECAIVSVKMAPELRQSVALLAQVQMRLEALEKKSARLHQRLELKISRQRRPHLDQRSSITKTIPGFWVTALLNHPHLSAHIDETDEDALSYMTDLEIESFKNNKLGYRIRFHFRRNPYFQNNIIMKELHLGMGGSPMSFSNPILWHRGHNLTAHSEPRKSSRGVYETFFSWFSDHSSPGQDDVAQILKDDLYRDPLRYYLTPLWEPRENGSSGTGARTADNGNGDDCVVISDSDDEPGEEAGEAEQGNSRDEEEEEEEEGEEEEERGQSADESPGEEEDGGEIVIDGSDDSDQEEEEEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMK4</accession>
    <name>A0A3P9DMK4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545281.1">
        <property type="nucleotide sequence ID" value="XM_004545224.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMK4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036020"/>
    <dbReference type="Ensembl" id="ENSMZET00005037290.1">
        <property type="protein sequence ID" value="ENSMZEP00005036020.1"/>
        <property type="gene ID" value="ENSMZEG00005026875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487043"/>
    <dbReference type="KEGG" id="mze:101487043"/>
    <dbReference type="CTD" id="364"/>
    <dbReference type="GeneTree" id="ENSGT00940000159054"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000005">
        <property type="entry name" value="Aquaporin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF15">
        <property type="entry name" value="AQUAPORIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="308" mass="32838" checksum="BF0B15E23D905A11" modified="2019-02-13" version="1">MKDLVQSVKPRVFQQRGGKVTRSKVWLKNELIRVGLAESLSTYVMMSLGLGSVAQVVTGQGAFGQYLSINLGFGLAVAMGSHVGGKISGAHMNGAVSFTMCVFRRLPWKMLPLYISAQLLGSFLAAGTIYAVYYEAIHDYCRGNLTVTGEKATAGIFATYPAPYLSLIAGFFDQVFGTAMLLLCLMALSDQKNKPAPAGSEPAFAGFLVLLIGISLGSNSGYAINPTRDIAPRVFTAMAGWGSDVFRAGNGWWWVPLVAPPIGGVLGAGLYKAVVELHHPHLSKAGGEMVEEAVPLDKEINTIENMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNB4</accession>
    <name>A0A3P9DNB4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deoxyribonuclease TATDN1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules. Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNB4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036295"/>
    <dbReference type="Ensembl" id="ENSMZET00005037569.1">
        <property type="protein sequence ID" value="ENSMZEP00005036295.1"/>
        <property type="gene ID" value="ENSMZEG00005027072.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156272"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000034">
        <property type="entry name" value="putative deoxyribonuclease TATDN1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="276" mass="31148" checksum="861F8124416556F3" modified="2019-02-13" version="1">MFRGLYRGKQKHDGELLLHSYFHCGFMITGGSLDDSREALKLAETRDEFYCTVGCHPTRCGEFEQNGESQYLTGLRELAAAHRGKVVAIGECGLDFDRLEFCSKETQLKYFEKQFDLAEETKLPMFLHCRNSHQEFIDIMKRNRDRCVGGVVHSFDGTAEDAAALIDLDLYIGINGCSLKTEANIEAMKSIPTERLMIETDAPWCGVKNTHAGSKCVKTTFPTKKKWEAGHCLKDRNEPCHIIQVLEVMAAAREEDPLELGNTIYNNTVKVFFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNV4</accession>
    <name>A0A3P9DNV4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
            <location evidence="1 9">Extracellular space</location>
            <location evidence="1 9">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNV4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036450"/>
    <dbReference type="Ensembl" id="ENSMZET00005037731.1">
        <property type="protein sequence ID" value="ENSMZEP00005036450.1"/>
        <property type="gene ID" value="ENSMZEG00005027205.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160329"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035284">
        <property type="term" value="P:brain segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021587">
        <property type="term" value="P:cerebellum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021592">
        <property type="term" value="P:fourth ventricle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030917">
        <property type="term" value="P:midbrain-hindbrain boundary development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19333">
        <property type="entry name" value="Wnt_Wnt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009139">
        <property type="entry name" value="Wnt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF91">
        <property type="entry name" value="PROTO-ONCOGENE WNT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01841">
        <property type="entry name" value="WNT1PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018155909" description="Protein Wnt" evidence="11">
        <location>
            <begin position="28"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="371" mass="41035" checksum="EF67E6413FB5B43E" modified="2019-02-13" version="1">TMRSLALLLGVKAACILLVPSLSGTGAVNNSGRWWGIVNVASSSNLLTNSKNVQLVLDPSLALLSRRQRRLIRQNPGILHAIAAGLHTAIKECKWQFRNRRWNCPTTHSPAVFGKIVNRGCRETAFVFAITSAGVTHAVARSCSEGAIETCTCDYRRRGPGGPDWHWGGCSDNVDFGRMFSREFVDSSERGRDLRYLTNLHNNEAGRMTVSSEMRQECKCHGMSGSCTVRTCWMRLPSFRTVGDFLKDRFDGASRVVYANKGSNRASHRADPRHLEPENPAHKPPSSMDLVYYEKSPNFCSYNGKTGTLGTSGRTCNSSSPGLDGCELLCCGRGFKSRTESVTERCHCTFHWCCHVSCLNCTSTRTLHQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPN2</accession>
    <name>A0A3P9DPN2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DPN2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036197"/>
    <dbReference type="Ensembl" id="ENSMZET00005037471.1">
        <property type="protein sequence ID" value="ENSMZEP00005036197.1"/>
        <property type="gene ID" value="ENSMZEG00005027004.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000175252"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052624">
        <property type="entry name" value="CRIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46439">
        <property type="entry name" value="CYSTEINE-RICH MOTOR NEURON 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46439:SF1">
        <property type="entry name" value="CYSTEINE-RICH MOTOR NEURON 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23334">
        <property type="entry name" value="VWC2L_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFC" evidence="1">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="1">
        <location>
            <begin position="165"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="1">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="320" mass="35211" checksum="10671BBBB57F1589" modified="2019-02-13" version="1">MLNLCPFHCVNSYAIESPVSKHECESMFVCVFLFFTEELRCAGVTCPNLQVPSCPEGSVLTKSYKPPAECCPSVPPQCTCDFSVCHKPQCPSEQHPVSLGQASGQPGDFTPKCVHSGKEYSEGEVYRMDPCWLCQCRGGISFCSKAECAELNCENFYIPEGECCPVCIGTHICFIIQLNCGETWNLDECTRCTCRKGRVLCDTELCPPALCQAPIRNKDTCCHVCEYCITSDGDVLLAGDSWKANVCTSCTCNNGTIQCFSQHCPAAKCRVPVLRKGQCCPHCLGEWLEPSHQWSAGGHFVALAVLVPFLLAQRSRYRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DT42</accession>
    <name>A0A3P9DT42_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT LRR and PYD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DT42"/>
    <dbReference type="Ensembl" id="ENSMZET00005038723.1">
        <property type="protein sequence ID" value="ENSMZEP00005037417.1"/>
        <property type="gene ID" value="ENSMZEG00005027901.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286904"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48007" checksum="84F2D23F861AC68C" modified="2019-02-13" version="1">MLIQASTSNPSGLLTRRSNNFYSSSTVILEILISINEGLFLCPREGFLLCVVAIPLLLKVQTSHNLKSTSHCCTEVIFRTQAKEVHCPNLLVLVLLIVRAGSGDPEPSLSYAAIEMDNRWIVVLCVCSLSGCLITEEGCTSLVSALSSNPSHLRELDLSYNDPGDSGMKLLSAGLKDPGWRLNTLRLSDCNLTERSCEALSSVLSCHTCSLQKLDLNNNDLQDSGITFLSVGLESPHCKLETLRYGIYIYIYIYMCVSSLWMFNYYISFSYSITFLRLSGCNLSERSCGALIRVIQSTNLREMDLGNNNLQDSGEILLSAALKSPCCKLESLRMLYYNFFIIVCQEFSYYLHRLSSCNLTERSCKALFSVLSFQLSSLRHLDLSNNDLKDAGVKALFAELANPPCKLETLRSDDITVFLFCFLCYEGGVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTK2</accession>
    <name>A0A3P9DTK2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTK2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005038075"/>
    <dbReference type="Ensembl" id="ENSMZET00005039477.1">
        <property type="protein sequence ID" value="ENSMZEP00005038075.1"/>
        <property type="gene ID" value="ENSMZEG00005028477.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005038075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="159" mass="17728" checksum="FB18B48B163847F8" modified="2019-02-13" version="1">MSLNVLYRDVISAVRNFFLRQVTIYSTFSCKLLADQPRATLTAGTTIIPVGGSVTLTCSVQSSDGWKYEWFRRTQTTSEGKIRGQQNRDIRVSQGGIYRCRGTRGNPVYYTDRSDDVTIEITSWMSPSLLCCSPSTPQHRKVLQQPLTGKTSSGASCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DU19</accession>
    <name>A0A3P9DU19_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_024656915.1">
        <property type="nucleotide sequence ID" value="XM_024801147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DU19"/>
    <dbReference type="Ensembl" id="ENSMZET00005039368.1">
        <property type="protein sequence ID" value="ENSMZEP00005037969.1"/>
        <property type="gene ID" value="ENSMZEG00005028389.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:112432644"/>
    <dbReference type="GeneTree" id="ENSGT00530000064359"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF45">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="447" mass="51338" checksum="6C383F0DEF760134" modified="2019-02-13" version="1">MDAATSLKKKLALPLIVALIFILLFNVNLPNNNNKSIPKPSGPAGVCSLGISEQTITPLKNTKHLLVSAYVDQRVKDLDIRIIGIFKRDSIQPLHCVFCCTNVLSKTTPATILQHSDHFGFPFTTTDVMCQIPQNCKATRVTLLTTPDKESASDSTWLPIRNQKSDRQKEENMKFDFTVCISNLFGDYNNVLQFAETLEMYRLLGVNRVVIYNTSCGPELDRLLQNYSQEGFVEMVPWPIDKHLNPSRGWLHSEHGGDVHYFGQLTTLNECIYRSMERSRYVLLNDIDEIIMPYQHKDLMSLMNTLQNQNPNTGVFLIENHTYPKKTFNQNKWGPLPQWNGVPGFDIMVHIYREEPNRNIYHPHKLIVQPRAVQQTSVHDVLMMSATKFKVPPDVCRIIHSPIRTPTDPPLDRLHVDTRLWDFKDKLLPNVIKVLRRAELLRSETQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARK6</accession>
    <name>A0A3P9ARK6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARK6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000339"/>
    <dbReference type="Ensembl" id="ENSMZET00005000398.1">
        <property type="protein sequence ID" value="ENSMZEP00005000339.1"/>
        <property type="gene ID" value="ENSMZEG00005000336.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234530"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF133">
        <property type="entry name" value="IMMUNE-TYPE RECEPTOR 5 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="129"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="327" mass="37448" checksum="06431D9676C30180" modified="2019-02-13" version="1">MLEQVTTVQLGEPATLTCVLPPGDLSTKIHWYKQRAGETLKLIATLRQTVHPQYGQGFNASRLEAKDNKNISSLTIFRTIPEDEGMYHCAVMEWNVNAWSGTYLLLKGNTQRNVTVRQWPTVLDSVHAGDSVTLNCSVLSDSDNKMCPGDLRVLWFRGQNSRPNIIYVDGKNQTECKKQSDTQKSCVYRFSKTVSSSDAGTYYCAVVTCGTILFGDGTQLQIETRPELEPVVLALGILLACCVSVIAFLLFYIKQSSTTKEHCRGRLIHTHTQNTHTPPYIHIYIYIYIYIYIYIYIYIYIYIYIYMYIYIYIYGLLHLPNSYRKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASM1</accession>
    <name>A0A3P9ASM1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase DHX29</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DEAH box protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DHX29</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the 43S pre-initiation complex (PIC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004549777.2">
        <property type="nucleotide sequence ID" value="XM_004549720.4"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005000699"/>
    <dbReference type="Ensembl" id="ENSMZET00005000772.1">
        <property type="protein sequence ID" value="ENSMZEP00005000699.1"/>
        <property type="gene ID" value="ENSMZEG00005000550.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157286"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000325">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03068">
        <property type="entry name" value="DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034730">
        <property type="entry name" value="DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056890">
        <property type="entry name" value="UBA_DHX29-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF264">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24899">
        <property type="entry name" value="UBA_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="578"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="848"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1366" mass="154286" checksum="C9B1347A3B3D5F24" modified="2019-02-13" version="1">MGGKKKKSPPQASAPAAPGNGVVEEPRKQAATSKPAKDSKSKAPKTYSLTNTAQVDTGGVSDKSILKVAIQADLEKKIIKLINEFRQENGDKGPISGRLTSKKLLDLYTALQKFNFKREHIEEAMKSSILYGGDLHSALDWLCLNLKDEELPDGFSQQMQEESQKNRPRFQPPVQQKPAAQDPKVSNNTTRREITKATEKDEAASMKDWILRYAEQSSEEEEEEGGKKTCNPELEEKFDPNDRYLILTVQLFDAKEMAAAAKTKADKAGQRMAQDRIRIIQQEMKQLESHPMFNPAIKVVDAPQKEKKILPAKEDKEELGFSLFEQAEKDPPAEKVVKKNEPKDIRNFDYTARSWTGKSPKQFLIDWVRKNLPKSPPPAFHKVACGRYWRCKVRVQRPDDVLEVCPTILTEDSMQAQHLGATLALYNLVKGQSVHQLLPPTYRDVWLEWRDSEQQQEEESRTAANKPRDQFISRLLTRLKQQQNQSQRQESQSQGKHASSADGDEEPEESWENLAGLDIGEKRQEQEDKSEKRGGRREVADLEAARELLLKLKKSPLARKLQAEREQLPVFQHRHRVLEALQRHPVVVVAGETGSGKSTQIPQFLLEDLLTGGTAAQPCNIVVTQPRRISAMSLACRVSQELGCEDGPGSKSSLCGYQIRMENQSGDWTRLLYCTTGVLLRKLQHDRHLTSLTHIIVDEVHERSVQSDFLLTILKDVVMKRSDLQLILMSATVDCDKFSNYFNRCPVISIPGRTFPVEVFHLEDIVEQTGYVLEKDSEYSQKILEEEEEVTISVTQKGGKTLQHQEVIVRDSSSGWDLGPDLDHFSSRTRHVLQYMNPNKVNMDLLVDLIDYLDKAPQFVDVDGAILVFLPGLAHIQQLFDLLSSDKRFRDKTRYRIVALHSTLSSKDQAAAFTVPPSGVRKIVLSTNIAETGVTIPDVVFVIDTGKTKENKYHESSQMSSLVETFISKASALQRQGRAGRVRNGFCFRLYPKYRFDIFMDYSIPEILRVPLEELCLHIMKCQYGSPEDFLSRALDAPQPQSVSNAVNLLRKIGACHPDDHILTPLGHHLASLPVNVKIGKMLIYGAILGCLEPIAIIAAAITEKSPFFTPMNRKEEANLAKAALAIANSDHLTIYNAYLGWKNSQTDGSRGEMSYCRKHFLNRTALITIEDVKRELMKMMEQVGFWSSRSSSSSSLKPQAASMSKQQISVLNAVLTAGLYDNVARVLCTPSVDVLERVACTVETPQGKAQVHFSSVNRNLQTHGWLLYQEKVKYTKIYLRDTTLISPFPMLLFGGDIDVQHRERLITLDGWIHFQAPVRIGVIFKHLRRLMDSLLERKLENPRMNLEGEATIRIILDLIKSEYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUF1</accession>
    <name>A0A3P9AUF1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUF1"/>
    <dbReference type="Ensembl" id="ENSMZET00005001396.1">
        <property type="protein sequence ID" value="ENSMZEP00005001306.1"/>
        <property type="gene ID" value="ENSMZEG00005001069.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01080000257344"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001230">
        <property type="entry name" value="Immunoglobulin kappa variable 8-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="130" mass="14180" checksum="FF17AE2077E4DB81" modified="2019-02-13" version="1">PRSREPAQLWSRRSLSFLHKYFVLPGAKSILTQTPTAHSAVGGSVSIKCTTSQDVFLSIALAWYQQKDGGVPKLLIYDADTLESGIPARFTGSGSDSDFTLTISGVQAEDAAVYYCQSVHEINSQYVFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUF8</accession>
    <name>A0A3P9AUF8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stabilizer of axonemal microtubules 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUF8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001345"/>
    <dbReference type="Ensembl" id="ENSMZET00005001435.1">
        <property type="protein sequence ID" value="ENSMZEP00005001345.1"/>
        <property type="gene ID" value="ENSMZEG00005001113.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000113054"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031410">
        <property type="entry name" value="SAXO4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34349">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34349:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15691">
        <property type="entry name" value="PPP1R32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="339" mass="37453" checksum="B9750CC376E9B9F1" modified="2019-02-13" version="1">MAEQGRIVIPATGAIGRKGQLTNNAVKLHNTTYTASHDRMGFTSYLGRPSETGFTSNHRPAIYYRPSLDHIDNPQFALLLSDSFVSQTKRHYQPPIHSGCSGSSTNIVNKPGNSGFHQLRIQPKTASVEEKTEYQSSFVPHRPTPAVSQNHVTVGPKGGSGFTKAAELQVNTSLMGEPHQTPSSVMKTDFMPLSLLQGTEAKSGLCSRSCRETGFTRGDIAPLAHPVSLLSSPQTKTEAPMPSIIGQKKPTGYVLNTHKNQTFPDAPLDPSDFITHYKSKFCHRDDRNWKSPEKFKSTNSCPRIVSSKMESGYNLRDTDRYVCYAQEVVSYRFPLTDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWI4</accession>
    <name>A0A3P9AWI4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA binding motif protein 25b</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AWI4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001782"/>
    <dbReference type="Ensembl" id="ENSMZET00005001877.1">
        <property type="protein sequence ID" value="ENSMZEP00005001782.1"/>
        <property type="gene ID" value="ENSMZEG00005001453.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111019"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000230">
        <property type="entry name" value="RNA-binding motif protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="4">
        <location>
            <begin position="720"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="818" mass="96457" checksum="877342F039D16D84" modified="2019-02-13" version="1">MSFPPHLNRPLLPPPGIPPQYTGFPPGAPMIPVHMGIMAPTPVMVSSVPVLSKPAVPKRETIAVIAKDSDENSGPTTTVFVGNISEKASDMLIRQLLAKCGIVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGDKNLLVKVDAKTKAQLDEWKAKKKTANGDKKSEDAGEDEEEVLDEETKKKDQIIKGAIDGLMREYAAELNAPSQDDESQRRKRKKEKKEEDDINTIDMEEDKRDLISREISKFRDTHKKLEEEKDKREKERLEFERERREREKERERERERRDREREKERERERERERERERDRDRDRDKDRDRRTRERERERERERDRSRDRSADRSRSREVSRDRDREKKRDQEDEEEAYERRKLERKLRDKEAAYQERLKNWELRERKKARDYAKEAEREDERRREMIKEGKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLDEGHPDPDAELRRMEEEEEERLRQPPIVQEPEPEEERERHRGSRDHRERRQEPERADSRSRPPQSDNEVEEGEEEDYDNDEDNPDVKPRLKPTMRPITAAPSVSSASGNVSPNTPGEESPCGIIIPHENSPPEALPQEEHRPKIGLSLKLGATGSPSQPNAGKRKKLPVDSVFDKFDDEEADEQPRKRKLVPLDYDDDKSLGVDGAGLSSIKGANAEEKRKHIKSLIEKIPTAKPELFSYPLDWSMVDTTLMERRVRPWINKKIIEYIGEEEPTLVDFVCSKVMAHSTPQTILDDVAMVSKDTVYRCLFMWFLCDCISCQDAGFFYLFYFIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXK6</accession>
    <name>A0A3P9AXK6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXK6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002369"/>
    <dbReference type="Ensembl" id="ENSMZET00005002477.1">
        <property type="protein sequence ID" value="ENSMZEP00005002369.1"/>
        <property type="gene ID" value="ENSMZEG00005001871.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165054"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF28">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="499" mass="58416" checksum="FF4458E17DF4FD97" modified="2019-02-13" version="1">MIHKIASKGNEFCSKIRYFLDARIAIPEKTPEEVIRSIIYVNDAEFRIAKGSDGTEVFLGLREDGTEVAIKRMSKSNYDELKNEEVILRHPELDHPYIVRYVDAAEDENFGYLCLQLCEYTLEEYIRNNDHDPLMLKKLVKQVLESLKVLHCQNPKILHRDLKPQNVLIDVTGRARLADFGISRRLLKGQTTLRTRSAGTKCWMARETLTEESVISYKSSTDIQVAGMLIYYILSGGHHPFGKSFECESNIYYGKYSLDHIQDEVAKDLIEWMINKEPKYRPKQKEDKRLLLHFERENQKLQELYKKMNYKATEMEGEKEKLQKQCSVMQSQLNDMLTKNTELEELSNTLKCKNTEVQLLKQQLEKTNEDLQCKLQETERKSQQLEDTHNKLQERYTEMQEAKVMQEETSKELKGRLKDKQAELEEVEKTCRRLEKENTETIDQLRTLILEKKVLVEKLLEKKKKRFCFFWRKDTPAFSTLSTFSTADVTSSSSTSVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXY0</accession>
    <name>A0A3P9AXY0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycoprotein endo-alpha-1,2-mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-{alpha-Glc-(1-&gt;3)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;3)-[alpha-Man-(1-&gt;2)-alpha-Man-(1-&gt;6)]-alpha-Man-(1-&gt;6)]-beta-Man-(1-&gt;4)-beta-GlcNAc-(1-&gt;4)-beta-GlcNAc}-L-asparaginyl-[protein] + H2O = alpha-D-glucosyl-(1-&gt;3)-D-mannopyranose + N(4)-{alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlaNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2)</text>
            <dbReference type="Rhea" id="RHEA:54824"/>
            <dbReference type="Rhea" id="RHEA-COMP:14010"/>
            <dbReference type="Rhea" id="RHEA-COMP:14011"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:52996"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:60627"/>
            <dbReference type="EC" id="3.2.1.130"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 99 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.130" evidence="9"/>
    <dbReference type="RefSeq" id="XP_004540391.1">
        <property type="nucleotide sequence ID" value="XM_004540334.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004540392.1">
        <property type="nucleotide sequence ID" value="XM_004540335.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004540393.1">
        <property type="nucleotide sequence ID" value="XM_004540336.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004540394.1">
        <property type="nucleotide sequence ID" value="XM_004540337.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXY0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002513"/>
    <dbReference type="Ensembl" id="ENSMZET00005002626.1">
        <property type="protein sequence ID" value="ENSMZEP00005002513.1"/>
        <property type="gene ID" value="ENSMZEG00005001998.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476482"/>
    <dbReference type="KEGG" id="mze:101476482"/>
    <dbReference type="CTD" id="79694"/>
    <dbReference type="GeneTree" id="ENSGT00390000016054"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004569">
        <property type="term" value="F:glycoprotein endo-alpha-1,2-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11574">
        <property type="entry name" value="GH99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000019">
        <property type="entry name" value="glycoprotein endo-alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026071">
        <property type="entry name" value="Glyco_Hydrolase_99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572">
        <property type="entry name" value="ENDO-ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13572:SF1">
        <property type="entry name" value="GLYCOPROTEIN ENDO-ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16317">
        <property type="entry name" value="Glyco_hydro_99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="440" mass="50688" checksum="5C25207640D12CD7" modified="2019-02-13" version="1">MARFKRKPCITLIALVLLILAITVFLSELISRDSPFSSPADIKGFPKPESQENRNKKPEEIKMSSAAQSDKDAELEATLRKFPPPNYYLHAFYYTWYGNPKIDGKYIHWDHPQLPHWDVKVAQGYPQGRHSPPDDIGANFYPALGVYSSRDPSVIEAHMQQLRTAAIGVIAVSWYPPNMKDDNGDSTDDIVPLLFEVAHKYHIKVAFHIEPYKGRDEVNMFTNVKYIIEKYGEHPAFFKYLTNTGKLLPLFYVYDSYLLNSEQWAKLLKHTETNSIRDTPYDAIFIALLVEEKDKRDILTAGFDGVYTYFATNGFSYGSTQRNWASIKAFCEDNNLMFIPSVGPGYIDTSIRPWNFQNTRNRINGKYYETSLSAALEARPDFISITSFNEWHEGTQIEMAIPKTSQTVYLDYLPNKPSIYLEITRKWAAIFGGERRKWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYB6</accession>
    <name>A0A3P9AYB6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein eL33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">60S ribosomal protein L35a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014266306.1">
        <property type="nucleotide sequence ID" value="XM_014410820.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYB6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002653"/>
    <dbReference type="Ensembl" id="ENSMZET00005002768.1">
        <property type="protein sequence ID" value="ENSMZEP00005002653.1"/>
        <property type="gene ID" value="ENSMZEG00005002093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473507"/>
    <dbReference type="KEGG" id="mze:101473507"/>
    <dbReference type="CTD" id="6165"/>
    <dbReference type="GeneTree" id="ENSGT00390000016972"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043009">
        <property type="term" value="P:chordate embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000005">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="110" mass="12442" checksum="5621C4DAC76334C3" modified="2019-02-13" version="1">MPGRLWSKAIFAGYKRGLRNQREHTALLKLEGCYSRDEVDFYLGKRCAYVYKAKKNTVTPGGKPNKTRVIWGKVTRAHGSSGMVRAKFSSNLPAKAIGHRVRVMLYPSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZ18</accession>
    <name>A0A3P9AZ18_9CICH</name>
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        <recommendedName>
            <fullName evidence="11">Forkhead box protein M1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZ18"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002931"/>
    <dbReference type="Ensembl" id="ENSMZET00005003047.1">
        <property type="protein sequence ID" value="ENSMZEP00005002931.1"/>
        <property type="gene ID" value="ENSMZEG00005002268.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158804"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20029">
        <property type="entry name" value="FH_FOXM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000245">
        <property type="entry name" value="forkhead box protein M1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047516">
        <property type="entry name" value="FH_FOXM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042839">
        <property type="entry name" value="FOXM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46878">
        <property type="entry name" value="FORKHEAD BOX PROTEIN M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46878:SF1">
        <property type="entry name" value="FORKHEAD BOX PROTEIN M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="14">
        <location>
            <begin position="168"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="12">
        <location>
            <begin position="168"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSMZEP00005002931.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="611" mass="67863" checksum="F501F7316D35E8F4" modified="2019-02-13" version="1">MRRSPRRPLILKRRKLPFHQNATDSQPGESGSKELSKPAAAQSFSDGIRIMDHPSKSDTQVVVIPEKANLQSVIGALTAKGKECGAQGPNKFILLNGGGSGNNVEFSAFFPLCLILVNKDVNCGPLDDSLTNIQWLGKMSTCALEPNSTNNSSLITENKAPQQPISERPPYSYMAMIQFAINSRKNRRMTLKEIYMWIEDNFPYYRDVAKPGWKNSIRHNLSLHDMFIRETSPDGKMSFWTIRPEANRCLTLDHVYKVSACFEIPHVVFHLIFPLISLHISLCKRKMKPLLPRTDSYLVPIQLPVTPSVYLPSTSTPFPPPCSQQKGNNSRGTKRVRIAPKVMNFSYISAFLKCVVVVVEVKEELVCVPIKCETPKAPPKRQASSSRRKQCLVLSVNEEPVLLCHESNFFDSGVASDASTFQDNPHIELDEDKHGQESPDREFSFKTPIKSRSHLTSSTPSKPPSYVALESWKVTPVGKGSQNILDFSPIRTPGGPTDTPQHDYTTFSFSSTPFKDLPLFNSPRELLTSAPSRVTGPAESPTECLKSSCSRELLQGGSSTTANRSITEGLVLDTMNDSLSKILVDISFSGLDDDDLGMANISWSEFIPQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0N1</accession>
    <name>A0A3P9B0N1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dynein cytoplasmic 1 intermediate chain 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0N1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003483"/>
    <dbReference type="Ensembl" id="ENSMZET00005003615.1">
        <property type="protein sequence ID" value="ENSMZEP00005003483.1"/>
        <property type="gene ID" value="ENSMZEG00005002671.1"/>
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        <property type="term" value="F:dynein heavy chain binding"/>
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        <property type="term" value="P:transport along microtubule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF37">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="387"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="549" mass="60456" checksum="E4D60B274AB73029" modified="2019-02-13" version="1">MGGSSAGHEDSDLERKRREAEALLQSVGITPDVPHVPAPMSPSNKSVGSDAGSQDSGDGNAGPRRGAVRLGMSKVTQVDFLPKEMVSYSKETQTPTEDEEITAPPPAEDNQEDKDEQDAPKELTEEEKLQLLHSDDFLSFFERGSRIVERALAEHVDVCFDYSGRDLEDKEGDLQAGAKLVLNRQFADERWTKNRVVTCLDWSPQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKPTPEYIFHCQSEVMSAGFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNANNLISISTDGKMCSWSLDMLSQPQDSLELVFKQSKAVAVTSMAFPLGDVNNFVVGSEDGSVYTACRHGSKAGITEVFEGHHGPVTGLSCHSAGGPVDFSHLFISSSFDWTVKLWSTKSTRPLYSFEDSCDYVYDAMWSPTHPALFACVDLAGRLDLWNLNNDTEVPTASVYVDGAPALNRVRWSHTGKEIATGDSEGQVQVYDVGEQICVPKADEWTRFVRTLAEINENRDEAEELANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3Y1</accession>
    <name>A0A3P9B3Y1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MAPK8</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3Y1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004594"/>
    <dbReference type="Ensembl" id="ENSMZET00005004797.1">
        <property type="protein sequence ID" value="ENSMZEP00005004594.1"/>
        <property type="gene ID" value="ENSMZEG00005003538.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153692"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07850">
        <property type="entry name" value="STKc_JNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000009">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="329"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="410" mass="46452" checksum="FF385E2CBDBF323D" modified="2019-02-13" version="1">MNKNKREKEFYSVDVGDSTFTVLKRYQNLRPIGSGAQGIVCSAYDQILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSFEEFQDVYLVMELMDANLCQVIQMELDHERLSYLLYQMLCGIKHLHAAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVILGMGYQANVDIWSVGCILAEMVRHKILFPGRDYIDQWNKVIEQLGTPSQDFLMKLNHSVRTYVENRPRYAGYSFEKLFPDVLFPADSDHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPAEVEAPPPKIPDKQLDEREHTVEEWKAVIDSPPQPTSSSSSSANDISSMSTEPTDPSSDPTMTSETDSSLDGHTSLGALACCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B483</accession>
    <name>A0A3P9B483_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B483"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004691"/>
    <dbReference type="Ensembl" id="ENSMZET00005004895.1">
        <property type="protein sequence ID" value="ENSMZEP00005004691.1"/>
        <property type="gene ID" value="ENSMZEG00005003630.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000203914"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="42"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="271" mass="31831" checksum="74EFAFC898E41A18" modified="2019-02-13" version="1">CKKKNKKGRFCCLRRKRSVSMASYGRDKRKDDRSSPPILKIITWNVRGLQSERLRKKKVLFLQKLDYDILCLQELRLKTKEDIEELIKLWGPSHSVVSIGEDSADGVGFFFKNTHVNIIKKRDIIPGRLLLVDCHYGGQKFRLINVYTAPERTKKMQLLKKMRHLLECGFNTVLCGDFNMVTEENDRIASTIFKESREGKLLTQICNDASLRDLYRILNPQTIHFTRFDSSSKTRIDRIYISSEIVALRYNDFSVKHKQNPWFRWASVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6J5</accession>
    <name>A0A3P9B6J5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane p24 trafficking protein 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">cis-Golgi network membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539154.1">
        <property type="nucleotide sequence ID" value="XM_004539097.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6J5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005519"/>
    <dbReference type="Ensembl" id="ENSMZET00005005752.1">
        <property type="protein sequence ID" value="ENSMZEP00005005519.1"/>
        <property type="gene ID" value="ENSMZEG00005004279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485390"/>
    <dbReference type="KEGG" id="mze:101485390"/>
    <dbReference type="CTD" id="791158"/>
    <dbReference type="GeneTree" id="ENSGT00940000158445"/>
    <dbReference type="OrthoDB" id="5976732at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="48"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="234" mass="26908" checksum="D44E8F37228F5EC8" modified="2019-02-13" version="1">MDALWRKSRNRGRLLVFAAVFVWYAGSVSCFGQSQDSEFTFLLPAGRSECFFQNAVKNGTMEVEYQVIAGAGMDVDFTVVSPQGIRLIYESRRSDGVHVVEPTEEGDYEICFDNSFSRFSEKMVFFEIIIEGQGGDVGGDDEWAGLEEPEGSLLEYKLEDIRESMESLYKRLERSRQMQTVLRAFEARDRNLLEDNLWRVSFWSCASVVVMLCVALTQVYTVRKLFDDKRRVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B7C9</accession>
    <name>A0A3P9B7C9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GST superfamily. Alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004555991.1">
        <property type="nucleotide sequence ID" value="XM_004555934.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004555992.1">
        <property type="nucleotide sequence ID" value="XM_004555935.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B7C9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005819"/>
    <dbReference type="Ensembl" id="ENSMZET00005006072.1">
        <property type="protein sequence ID" value="ENSMZEP00005005819.1"/>
        <property type="gene ID" value="ENSMZEG00005004494.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469751"/>
    <dbReference type="KEGG" id="mze:101469751"/>
    <dbReference type="GeneTree" id="ENSGT00940000161750"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000005">
        <property type="entry name" value="Glutathione S-transferase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003080">
        <property type="entry name" value="GST_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF230">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01266">
        <property type="entry name" value="GSTRNSFRASEA"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="85"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="220" mass="25301" checksum="D2557E7B5BEAE19A" modified="2019-02-13" version="1">MGERVVLHYFNGRGKMESIRWLLTVAEVEFDEKFLDTREEYLKLVNDGKLMFQQVPLVEIDGMKLVQTKAILNYLAEKYNMHGKDLKDRVMINMYSEGLMDLMEMIMVLPFNPDPTAKLEEIEKKAKERYFPVFEKALTGPVYLVGGKLSLADVLLVECTLMLEEKCVGILKDFSAVKSFQGRMIQIPAINRFLQPGSKRKPPPGENYAKAVIEIFQIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B8I4</accession>
    <name>A0A3P9B8I4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G protein-coupled receptor 68</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004569984.1">
        <property type="nucleotide sequence ID" value="XM_004569927.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012779764.1">
        <property type="nucleotide sequence ID" value="XM_012924310.3"/>
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        <property type="nucleotide sequence ID" value="XM_023153607.2"/>
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        <property type="protein sequence ID" value="ENSMZEP00005006195.1"/>
        <property type="gene ID" value="ENSMZEG00005004820.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472621"/>
    <dbReference type="KEGG" id="mze:101472621"/>
    <dbReference type="CTD" id="8111"/>
    <dbReference type="GeneTree" id="ENSGT00950000183136"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cellular response to pH"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="G-protein coupled receptor 4"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="OVARIAN CANCER G-PROTEIN COUPLED RECEPTOR 1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="57"/>
            <end position="79"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="99"/>
            <end position="118"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="158"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="209"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="39"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="405" mass="46640" checksum="AF9E51315EC3AF46" modified="2019-02-13" version="1">MMVINKSEEDMSNCSINHGIHQHVFSCVYILVLMVGVPANVYSLYHAALQLKQRNELGVYLMNLTVSDLLYLASLPFWLQYFFQDDDWRHREWLCQMCGFLLYENIYISIGFLCCISLDRYLAVVHPLRFTALRSMKAASVISAIIWLKEIAVGVFFFHHKELSKDPSNHSLCFEHYPMKSWERPINYYRISIGFMFPLAILLISYLWVLRAVGRSAGTQPDQKMRIRQLVSSTILIFLVCFSPYHVFLLVRTLLEEECSFIEAIFNYYHLSLLLTTLNCVADPVLYCFVSESARRGLYRVVFRPVARILCCCRRRGNASPASPANDSHEVATDENNGQPNVTLLTHSNTLNNGQMDAACRNTSLITRMHEESVKARVTENNTLEMCVTEKQKQNPDRTEGRGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9C9</accession>
    <name>A0A3P9B9C9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dpy-19 like C-mannosyltransferase 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024655257.1">
        <property type="nucleotide sequence ID" value="XM_024799489.1"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005006485"/>
    <dbReference type="Ensembl" id="ENSMZET00005006783.1">
        <property type="protein sequence ID" value="ENSMZEP00005006485.1"/>
        <property type="gene ID" value="ENSMZEG00005004977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467630"/>
    <dbReference type="GeneTree" id="ENSGT00530000063023"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF4">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="753" mass="85645" checksum="CA6CD012D1EF4188" modified="2019-02-13" version="1">MELRKRVKPKHGLSQDAPSEGRCNHNALSGTQEGGEGGVSLLGRSGSRSHSGSGVSPLRPWQQCVFMAAGLLAAVLLALTQAWCVNGLHENLLWFSQLTEVEREISFRTECGLYYSYYKQMLHAPSIQEGLKEMIHDNLTESKRTINLLQRMNIYQEVFLSVLYRLLPIQSYLEPVYFYIYTVFSLQAVYVIALYLTAWLLSGSWLAGALTGVWYILNRVDTTRVEFTISLRENWSLPFLALQVAAITCYLRPQLITLQQKVMVWLMYVTTFCFCLTWQFNQFILLVQALVIYTLDCGDFLTTTQVTTLYLVQVSSLLSVWFLQFCNSMILGSLVLSFIVAALFIRHCQPGVKTGSLVVRLGKVLLHSALVLLLTVTINYLAKKALQLQSDEHIFKFIKSKFALGSTRDFDASLYLCEEAFGLLPLDTLERLAGTLLLYPYVLTLLLLCGMLVAAALQNLSRPNRGSTEEKKGAREGQVAAFRPDVAYNLLHTLFYGLLAFSTMRMKYIWTGHMCAVAAYGVCGTELWTVLLSALRCNTKLLLRLVRYVVPVVMIGFLYYKFWPKLMEELSELREFYDPDTVELMTWISTKTPKQAVFAGSMQLLAGIKLCTGRVLTNHPHYEDKDLRERTRQVYQVYARRSPEEVYDILKAIGADYVVLENSICYERRHRRGCRLRDLLDLANGHIMDGPGEDDPDLVPATHPRFCDAIKTDAAAYNTLFTRTFQNKTFHVYRLKKKRKKNTKGSSEPSVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9X7</accession>
    <name>A0A3P9B9X7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Si:ch211-160o17.6</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9X7"/>
    <dbReference type="Ensembl" id="ENSMZET00005006998.1">
        <property type="protein sequence ID" value="ENSMZEP00005006699.1"/>
        <property type="gene ID" value="ENSMZEG00005005159.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011228"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009533">
        <property type="entry name" value="FAM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768">
        <property type="entry name" value="DOWN REGULATED IN RENAL CARCINOMA 1/TU3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16768:SF7">
        <property type="entry name" value="PROTEIN FAM107B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06625">
        <property type="entry name" value="DUF1151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="111" mass="13292" checksum="800C8412770D8B9F" modified="2019-02-13" version="1">KKLNGSSTEAPSYHNLHRELLLSHKRGLLLEEKPELKRVLEQRRLELHKEAEMAQRQPSDLEMELRKRQQKLQEEIRQRESQQKIPEFVRVKDNLRRTQTKDADVEEQTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD72</accession>
    <name>A0A3P9BD72_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine protease 23</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004543468.1">
        <property type="nucleotide sequence ID" value="XM_004543411.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD72"/>
    <dbReference type="Ensembl" id="ENSMZET00005008146.1">
        <property type="protein sequence ID" value="ENSMZEP00005007828.1"/>
        <property type="gene ID" value="ENSMZEG00005005972.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477143"/>
    <dbReference type="KEGG" id="mze:101477143"/>
    <dbReference type="GeneTree" id="ENSGT00390000000155"/>
    <dbReference type="OrthoDB" id="10037376at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF10">
        <property type="entry name" value="SERINE PROTEASE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018126844" description="Serine protease 23" evidence="10">
        <location>
            <begin position="30"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="160"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="408" mass="45962" checksum="46BD4F36B77F6D4A" modified="2019-02-13" version="1">MPRSRAELPRLTGLLVLLFLLPVFPFSSSSSSSSSHPQWVLQRIPVVIPQHTEARPAPHFLSQARLDVTSTCDPECHKKAPHPSYWDLRSLLAYETLHSNGRLTETAIRIYGYNPNSNTTPAYLTGSSGKAERSHVRRKRQIFGHDGRFSIAGQDFLLKYPFSVAVKLSTGCSGTLVGDRHVLTAAHCVHDGKNYVKGAQRLRVGFLKPKQRDTQQSSFHLLSNFTNHVEGGPSPYAPPTSDIMKFQWIRAKRTHVPKGWIKGNANDIGMDYDYALLELKKPHKRRHMKLGVSPPAQGLPGRRVHFSGFDNDRPGQLVYRFCRAGEETSDLLYQHCDAQPGASGSGVYARMWAGRRWERKVIGVFSGHQWVERQGASQEFNVAVRITPLKYAQICYWIKGNFMDCREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEC1</accession>
    <name>A0A3P9BEC1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Platelet-derived growth factor beta polypeptide a</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PDGF/VEGF growth factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574586.1">
        <property type="nucleotide sequence ID" value="XM_004574529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEC1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008249"/>
    <dbReference type="Ensembl" id="ENSMZET00005008577.1">
        <property type="protein sequence ID" value="ENSMZEP00005008249.1"/>
        <property type="gene ID" value="ENSMZEG00005006286.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487929"/>
    <dbReference type="KEGG" id="mze:101487929"/>
    <dbReference type="GeneTree" id="ENSGT00940000157367"/>
    <dbReference type="OrthoDB" id="8878063at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005161">
        <property type="term" value="F:platelet-derived growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001525">
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        <property type="entry name" value="Platelet-derived growth factor beta polypeptide b"/>
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        <property type="entry name" value="Cystine-knot cytokines"/>
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        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR"/>
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        <property type="entry name" value="Cystine-knot cytokines"/>
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        <property type="entry name" value="PDGF_2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="3" id="KW-0497">Mitogen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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    <feature type="chain" id="PRO_5018048563" evidence="6">
        <location>
            <begin position="24"/>
            <end position="552"/>
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    <sequence length="552" mass="62214" checksum="36F5B75BD8131638" modified="2019-02-13" version="1">MRSWVLVLLLAALLAARLRLGSAEGDPLPSSLVDLVRNSPISSVEDLKLLLQEETDAIEEEEDVHDIIPKGTHGRYIRSLVEAQPAQQAACKVRTEVMEVTRSMLDRRNANFLLWPPCVEVQRCSGCCNSPRMECVPIVTSTRYLQVIKIQYINKKPHYEKPIIPVEDHVSCRCQSLSSFSSSSVPSNPIPPPPPPQQPPLSSHVPRLVQPPSPKTQTSKADLHRHDDLKYNQQHYGPEEREPAVRQWQHGSYTQLVHWTQPRVHQIPQPGLPRPVSSWPSEARAEHSVMGSTQQVGHGSGFEGSREESGVHTSHSGGQVHHPDHAKRQQQLLEHQQRHQHHQHHHHHHHQSHYPQQYNHGATEDRELRTQYRLDTPQSDSASPPASQTEPPKFEETSTLPLTTIQKDFVTSQKSIEVTNHKQAETETASQKEGNEREESGSANSGDSATTELANQGKKKDSNVTGEDGRLTEAERRQKLLELVQREPSEQTHLHPLHPHQRPKPTTFKTASSTAAPISPSARKAPFRPASPRRRRKNRKRISKAAIRAMIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BF08</accession>
    <name>A0A3P9BF08_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BF08"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008478"/>
    <dbReference type="Ensembl" id="ENSMZET00005008816.1">
        <property type="protein sequence ID" value="ENSMZEP00005008478.1"/>
        <property type="gene ID" value="ENSMZEG00005006437.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000916"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000771">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000958">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="579"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="632"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008478.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="788" mass="86934" checksum="37202E32F0A89F6C" modified="2019-02-13" version="1">MAAAVIETCHVACCANRTPNVVSWGRGGTIAYGTCNSVALYDPEERRVVALLNGHTSRVNAVQWVHREDSGECGENGSVECKGHTGPVCAADAIYVEDSKILVASSASDSTVKLWLCCDAKQAECLHNLSFGSGFMMDVSLVLLPGSRVPILACGGDDSRVHLYVQADGQLQRAMSLQGHEDWVRGVEWASTGGELLLASCSQDSLIRVWRLCAKSGTDTHAEDNHSIIKMKEDIFESSVYAVSLETVLAGHENWVYGVHWQPPLYQGGELQQRLCLLSASMDKTMILWAPEEGSGVWIEKVRVGEVGGNTLGFYGCQMSADGSMILAHAFHGALHLWCKDLDKEWRPGVVISGHFNAVQDLSWDPEGEFILSVGSDQTTRLFTPWRTQESKKVTWHEISRPQIHGYDMQCLAMIGRFQFVSGADEKVLRVFQAPRNFVENFANISGTSKETLLTSCDSADLPEGASTPALGLSNKAVFQGDLVPKNKEEGEQFNRVSDQYQESYFHPLNLTEPPPEDHLLQNTLWPEVQKLYGHGFEMFCLASDSSRTVVASACKASKAEHAAVLLWSTTTWRQLQVLPCHTLTVTQMAFSPDAQLLLAVSRDRTWSLWRRNLPTPEKPLFSLYAHTEKDTAIHSRIIWSCDWSPDGKFFVTSSRDKKVIVWGPCSLDSGDPVLPPEIKPCSSILDVGDSATAIAFCPVLCSNDSYLLAVGLECGRIRLYRWSPGSEPAGDDWSCCGETDTSQSHTLAVKRLRWRPKTGREESSWVQLASASADHSVKIFNINKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BF60</accession>
    <name>A0A3P9BF60_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized LOC112430931</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BF60"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008381"/>
    <dbReference type="Ensembl" id="ENSMZET00005008714.1">
        <property type="protein sequence ID" value="ENSMZEP00005008381.1"/>
        <property type="gene ID" value="ENSMZEG00005006390.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182968"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF133">
        <property type="entry name" value="IMMUNE-TYPE RECEPTOR 5 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018080305" evidence="9">
        <location>
            <begin position="18"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="136"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="316" mass="35025" checksum="121B5E8BE9DB9A0A" modified="2019-02-13" version="1">MKMFFVNVFLICSLCAAQLSDVSQPESLKTVKIGDSATIKCFVKSASTKTVWYKVTTGRKLQLVVKADSQYNVREFSDEFVNRSSVKFDMTNNHLTINKTSWEDVGTYFCGVLHISEVQFGSGTFLMLTGAKTISDSVVQQPESKSVRSGDSVTLSCSLHSAQCTAELISFMWLKNSDRSAPEMIYCSDNKNNISQRTDRGRTTCVYNFVVRSRDDAGVYYCAVNACGQILLGNGTKIGISNFGRTLSCIIIIIIIMGVYLVFAVFMISKRNRYHCTETDAVDLYTVCSTEHNVNHFACFSEFSSGLSPLSKVCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIR6</accession>
    <name>A0A3P9BIR6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIR6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009601"/>
    <dbReference type="Ensembl" id="ENSMZET00005009960.1">
        <property type="protein sequence ID" value="ENSMZEP00005009601.1"/>
        <property type="gene ID" value="ENSMZEG00005007259.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164529"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001160">
        <property type="entry name" value="Alcohol dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000007">
        <property type="entry name" value="Alcohol dehydrogenase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="24"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="383" mass="41472" checksum="368EBD812B1D3F56" modified="2019-02-13" version="1">MTLVDNFNIVTFKVIKCKAAVAWESSKPLVIEEIEVAPPQANEVRIKIVATSLCHSDLYFLYESLDKSLFPTILGHEGAGIVESVGLGVTEFQPGDKVIPLFLLQCGECRFCKSPKTNRCEEAMKRHAQKSTEHSRLTCKGQKLQQFMGTGTFSEYTVMNQMAVVKIDPAAPLDKVCLLGCGVCTGYGAAVNTAKVEPGSTCAVFGLGAVGLAAVMGCKAAGAKRIIAVDINPDKFEKAKVFGATDFVNPKDHNKPISQVLMEMTGGGVDYSLECIGNVECMRSALESCVAGWGVSVIVGWTDLHDVATRPINLMLGRTWTGCLFGGFKGKGGIPRMVKAYLDKKVMLDEFITHNMTVDQVNDAIELLKNGKSIRTVMRFSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ27</accession>
    <name>A0A3P9BJ27_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA wybutosine-synthesizing protein 2 homolog</fullName>
            <ecNumber evidence="2">2.5.1.114</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004545793.2">
        <property type="nucleotide sequence ID" value="XM_004545736.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004545794.2">
        <property type="nucleotide sequence ID" value="XM_004545737.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ27"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009706"/>
    <dbReference type="Ensembl" id="ENSMZET00005010066.1">
        <property type="protein sequence ID" value="ENSMZEP00005009706.1"/>
        <property type="gene ID" value="ENSMZEG00005007349.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101477717"/>
    <dbReference type="CTD" id="55039"/>
    <dbReference type="GeneTree" id="ENSGT00940000153304"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000002">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000201">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056745">
        <property type="entry name" value="TYW2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25132">
        <property type="entry name" value="TYW2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="10">
        <location>
            <begin position="118"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="401" mass="44782" checksum="BF619C03FA023EE4" modified="2019-02-13" version="1">MDSVPCLRVPQCQAQKLRRSLQSKGALDLSLSLVKDSDGTVLLPILASCLSQLDLQSFRTTVASDDDFEVVWSKSALQSKKEKGRASSSKLEKVLQELLESHGERWTEELKRDIPRSFQRHGDLVLLGDTCFVLPLWENMDQQLWSTVARGLGAKRLAKIRRISRDGFRSPEVTMLLGAHSWVKHVDNGISYEFDVTKCMFSAGNITEKLRVAGFYCRGETVVDLYAGIGYFTLPYLVHAKASHVHACEWNPNAVEALKKNLEANGVSDRCTIHQGDNRQLQLCGVADRVNLGLIPSSEDGWSVACRLLRRATGGVLHIHQNVTSPVEHSTAGDAPQKVSGKKADREVWQAWAEDTAKHFTSLLKDFNGTQWTTNIQHIEHVKSYAPHVHHVVLDLECRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJV3</accession>
    <name>A0A3P9BJV3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Disco-interacting protein 2 homolog B-A</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005010210"/>
    <dbReference type="Ensembl" id="ENSMZET00005010579.1">
        <property type="protein sequence ID" value="ENSMZEP00005010210.1"/>
        <property type="gene ID" value="ENSMZEG00005007678.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182997"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000002">
        <property type="entry name" value="Disco interacting protein 2 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF38">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="712"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1291" mass="140872" checksum="F2A709C6EB637AD2" modified="2019-02-13" version="1">CNYGPHCCCEMRVPVSSRVSTKIQQLLNTLKRPKRPPLSDFFTDDAEEIVEVPQPDPNTPKPEGRQIIPVKGEPLGVVSNWPPALQAALARWGATQGKSPALTALDITGKPLYTLTYGKLWSRSVKLAYTLLNKLGTKNEQILKPGDRVALVYPNSDPGMFWVAFYGCLLAEVIPVPIEVPLSRKDAGISQVGFLLGSCGVGLALTSEICLKGLPKTPTGEILQFKGWPRMKWVITDSKYLTKPSKDWQPHIPTANTDPAYIEYKANKEGTVVGVAVSKVAMLTHCQSLTQACNYCEGETLVNVLDFKKDMGLWHGAVMNRIHTISVPYAVMKACPLSWVQRVHIHKARVALVKCRDLHWAMMAHREQRDISLASLRMLIVADGANPWSVSSCDAFLNKFQSHGLKPEVICPCATSPEAMTVAIRRSGVPGAPLPARAILSMGGLSHGVIRVNTEDKNSALTVQDVGHVMPGALMCIVKPDGPPQLCKTDEIGEIIINSRAGGNMYYGLPGLTKNTFEVIPVNANGVPIGEIPFVRSGLLGFVGPGSLIFVVGKIEGLLMVSGRRHNADDLVATALAVEPVKTVYRGSLHSVCLQYNLQSLDIHQVGLYCLALVPANTLPKTPLGGIHISDTKQFFLEGNLHPCNILMCPHTCVTNLPKPRQKQPVGVGPASVMVGNLVAGKRIAQAAGRDLGLIEDQDLVRKHQYLTEALQWRAQTDPDHVLYILLNAKGVTVGTATCVQLHKRAEKIAAALTEKGSINTGENVVLLYPPGIDLIAAFYGCLYAGCVPVNVRPPHPQNLAATLPTVRMIIDVSKAACILTTQNLMRTLRSKEAAASVNVKTWPTIIDTDDLPRRRPPQIYKPPTAEMIAYLDFSVSTTGMLTGVKISHAAVSALCRSIKLQCELYSSRQIAICLDPYCGLGFVLWCLASVYSGHQSILIPPFELETSLSLWLSTLSQYRIRDTFCSYSVMELCTKGLGTQTDLLKARGVNLSCVRSCVVIAEERPRLALTHSFSKLFKDVGLSSRAVSTAFGSRVNLAICLQGTTGPDPCTVYVDMKSLRHDRVRLVERGAPQSLPLMESGKILPGVRVIIVNPETRGPLGDSHLGEIWVNSPHSASGYYTIYGEESLQADHFNTKLSFGDPHTLWARTGYLGFVKRTELLDASGDRHDALFVVGSLDETLELRGLRYHPIDIETSVSRAHRSIAESAVFTWTNLLVVVSELCGSEQDALDLVPLITNVVLEEHHLIVGVVVIVDPGVIPINSRGEKQRMHLRDSFLADQLDPIYVAYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLX1</accession>
    <name>A0A3P9BLX1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proline-rich nuclear receptor coactivator 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004551075.1">
        <property type="nucleotide sequence ID" value="XM_004551018.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLX1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010927"/>
    <dbReference type="Ensembl" id="ENSMZET00005011305.1">
        <property type="protein sequence ID" value="ENSMZEP00005010927.1"/>
        <property type="gene ID" value="ENSMZEG00005008200.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487357"/>
    <dbReference type="KEGG" id="mze:101487357"/>
    <dbReference type="CTD" id="55629"/>
    <dbReference type="GeneTree" id="ENSGT00530000063881"/>
    <dbReference type="OrthoDB" id="8732832at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026780">
        <property type="entry name" value="PNRC1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15405">
        <property type="entry name" value="PROLINE-RICH NUCLEAR RECEPTOR COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="156" mass="16941" checksum="1E7C88026ACDF2FF" modified="2019-02-13" version="1">MGGGERYNIPVTHPERPLAKKNHQLGRAKQRSRDQNGAAASVGGAGGLHHHGHRRSEKGAAYHRSPETRQAVSAEKNASVRFSTNYDQNWEGAVSHLNTLLATQGSPSYAGPKFSEPPSPSVLPKPPSHWVSFPIGSCDNREVMTFQLKSLLKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNU7</accession>
    <name>A0A3P9BNU7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prenyl (decaprenyl) diphosphate synthase, subunit 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559341.1">
        <property type="nucleotide sequence ID" value="XM_004559284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNU7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011594"/>
    <dbReference type="Ensembl" id="ENSMZET00005011996.1">
        <property type="protein sequence ID" value="ENSMZEP00005011594.1"/>
        <property type="gene ID" value="ENSMZEG00005008691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477017"/>
    <dbReference type="KEGG" id="mze:101477017"/>
    <dbReference type="CTD" id="57107"/>
    <dbReference type="GeneTree" id="ENSGT00940000153498"/>
    <dbReference type="OrthoDB" id="9983019at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="385" mass="42175" checksum="353D44342EF2049E" modified="2019-02-13" version="1">MFSPCWSRLSCVALSSRGRLRTLSLFSSSGSSNWSKVVSDAEKIVGYPTSFMSLRCLLSDELSNVAMHLRKLVGTQHPLLNTARGFVYDSKNNLQMRGLVVLLLSKAAGPSHAASDLLAQDMVSGIYPSQRNLAEITELVHTAFLVHRGIVNLKEWTDSDGPLKDMQFGNKMAVLSGDFLLANACTGLAQLNNTKVVELISSAIGDLVQGVYYENSHNTEENGLTDGIDVAAWEEQTFLSHGALLAKSCQAAMELAKHDKESQRLAYKYGKHLSLGHKLNSDLQPFMKSRVGEPLSFSLSAAPVVFHRQIMGRETWHHQLQQAKTLRNQLDYSKLLAAVKSEKGVSTAMDLCCYHGNKALEAIQAFPSSEARSALENIASAVTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BPB3</accession>
    <name>A0A3P9BPB3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase 1, regulatory subunit 27a</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004560737.1">
        <property type="nucleotide sequence ID" value="XM_004560680.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BPB3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011466"/>
    <dbReference type="Ensembl" id="ENSMZET00005011863.1">
        <property type="protein sequence ID" value="ENSMZEP00005011466.1"/>
        <property type="gene ID" value="ENSMZEG00005008606.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479835"/>
    <dbReference type="KEGG" id="mze:101479835"/>
    <dbReference type="CTD" id="100332066"/>
    <dbReference type="GeneTree" id="ENSGT00940000159603"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053080">
        <property type="entry name" value="PP1_regulatory_subunit_27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46899">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46899:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="235" mass="26330" checksum="9BC10D3484571EA4" modified="2019-02-13" version="1">MKYSYRVPASTYARSSQYTPTYHTTTQYTPSYYTPPPYTSSYTSASKYKPTQYSTTYYTPSHHTSTYKPASAYVPSYSKGSRYSSTCGTQAQEKPAPVIPVTPAKRTVHFPNDIIFQDIVRRGDLEQIGRFMRARKVRVDTVFHSGMAALHEAVLTGNLEVVKLLVKYGADVHQRDEDGWTPLHMACSDGYPEIARYLLSMGASTEAENENGEKPADLIDPECKDLAKLFETGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQ72</accession>
    <name>A0A3P9BQ72_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Roundabout guidance receptor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the immunoglobulin superfamily. ROBO family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005012087"/>
    <dbReference type="Ensembl" id="ENSMZET00005012514.1">
        <property type="protein sequence ID" value="ENSMZEP00005012087.1"/>
        <property type="gene ID" value="ENSMZEG00005009061.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154477"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022603">
        <property type="term" value="P:regulation of anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035385">
        <property type="term" value="P:Roundabout signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07693">
        <property type="entry name" value="IgC_1_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05725">
        <property type="entry name" value="IgI_3_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05726">
        <property type="entry name" value="IgI_4_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20952">
        <property type="entry name" value="IgI_5_Robo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000053">
        <property type="entry name" value="Roundabout guidance receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000055">
        <property type="entry name" value="roundabout homolog 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000065">
        <property type="entry name" value="roundabout homolog 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="roundabout homolog 2 isoform X1"/>
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        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="roundabout homolog 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032986">
        <property type="entry name" value="Robo1_Ig-like3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF243">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="103"/>
            <end position="190"/>
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    <feature type="domain" description="Ig-like" evidence="18">
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            <begin position="195"/>
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    <feature type="domain" description="Ig-like" evidence="18">
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            <begin position="284"/>
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    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="388"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="496"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="609"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="19">
        <location>
            <begin position="711"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1089"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1140"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1230"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1282"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1350"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1096"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1166"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1230"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
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            <begin position="1251"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1309"/>
            <end position="1321"/>
        </location>
    </feature>
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            <begin position="1366"/>
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            <begin position="1388"/>
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        <location>
            <begin position="1416"/>
            <end position="1425"/>
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        <location>
            <begin position="1449"/>
            <end position="1484"/>
        </location>
    </feature>
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        <location>
            <begin position="1518"/>
            <end position="1528"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1543"/>
            <end position="1552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1593" mass="173854" checksum="EE6C86D615C21DDF" modified="2019-02-13" version="1">PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTVEWYKDGERVETDRDNPRSQRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSHNASLEVAILRDDFRQNPADVIVAAGEPAVLECQPPRGHPEPTISWKKDGVNIDDRDERITIRGGKLMITNARKSDAGKYVCVGTNMVGERESEIAELTVLERPSFVRRPSSQVVLVDQSVEFRCEARGDPVPTVRWRKDDGDLPKGRYEIREDHTLKIRRLVSADVGSYTCVAENMVGKAEASATLTVHVPPAFVVRPKNQVVGVGRTVTFQCEATGNPQPAIFWQREGSQNLLFSYQPPQPSSRFSVSQTGDLTITDAVRSDGGYYSCQALNIAGSVITKALLEVTDVVSDRPPPVIRQGPTNQTVAVDGTVVLNCVTSGNPTPTILWRKDGVLVSTHDSRVKQLDTGALQIRYAKLSDTGTYTCTASTPSGEASWKAYLEVQESGAQFQPNRPTDPNLIPSAPSKPEVTDVTRSSVTLSWKPNLNAGATPTSYIIEAFSHASGSSWQTLAEHVKPESFVLKGLKPSAVYLFLVRAANAYGLSDPSPITDAVKTQDIPPTSQGVDHRQIQRELGDAVIHLHNPTILSSSSVRVQWTVEQQSQYIQGYKVMYRPSPEGQQRSEWAVFEVRTPGEGSAVVPHLRKGVTYEFKVRPFFNEFQGTDSDVKIGKTLEEAPSAPPRKVTVTESGDNGTAIIVSWQPPPEEEQNGVVQEYKIWCLGNETRYHINRTVDGSTFSVLIPSLAPGIRYSVEVAASTGAGPGVKSDVTFFQLDASGRMTDTVNQENPLSQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLSSSYAGIRKVAYQRGGEGVSSAGRPGLLNIGDSATQPWLADTWPNSCSNHNDCSINCCTAGNGNSDSNLATYSRPADCIANYNNQMENKQTNLMVPESGVYGDVDLSNKINEMKTFNSPNLKDGRFVGPGGQPTPYATTQLIQSSIMGNNMNSDRVTGGSGGGLVGGGEVNEKHCWKPPSVQQQKQEISSQLQYNIMEQNKLNKGECVEYQGQKKGVRTPKVPKQSTMNWADLLPPPPANPPPTRNTEEYSLPMEESCDPDMQCPMPPSHMYLQPDELEEEEEMERGPTPPIRGAASSPAAVSYSHQSTATLTPSPQEEMQPMLQDAPDSHERRRHAVSPPPPPRPMSPSHTYGYINTPLALDTDGMEEEDILEEEEDGDETDAEVAKMHYHHTHPHTNPHHPQMHPRRLLLRGLEQTPASSMGDLESSVTGSMINGWGSASEEDNVSSGRSSAVSSSDGSFFTDADFAQAVAAAAEYSGLRVAKYPNSQGQEVGGASARKYQINPSSHRPGSPVSTDSNMSMAAVHRRPPKKQKQHPVGHPANQRREVFNEDLPPPPIPPPAVLKSPTHPSKVALEGRGVISPKAGEGRDKRGGTGGYRAREDSDPRTSSSERKDAQDRQKTAHGGKGNKHESSTTNKARQHAGSEDIMPYSRPQFPTVNSPRDPSSSSSMSSRGSGGRRRGEGGRRNPADMGLNTSRAFQPGDEEIEVKGSLRLYFSEIYLMGICILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQ93</accession>
    <name>A0A3P9BQ93_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Glutathione reductase</fullName>
            <ecNumber evidence="21">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16 21">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 21">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 21">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="21"/>
    <dbReference type="RefSeq" id="XP_012773146.1">
        <property type="nucleotide sequence ID" value="XM_012917692.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQ93"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012110"/>
    <dbReference type="Ensembl" id="ENSMZET00005012537.1">
        <property type="protein sequence ID" value="ENSMZEP00005012110.1"/>
        <property type="gene ID" value="ENSMZEG00005009098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474090"/>
    <dbReference type="CTD" id="2936"/>
    <dbReference type="GeneTree" id="ENSGT00940000156986"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000484">
        <property type="entry name" value="Glutathione reductase, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin reductase 2, tandem duplicate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
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    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
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        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
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    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FADPNR"/>
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    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 21" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="8 21" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14 20" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="23">
        <location>
            <begin position="40"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="22">
        <location>
            <begin position="388"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="212"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="19">
        <location>
            <begin position="76"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="499" mass="53966" checksum="6C3EF5471246CCC9" modified="2019-02-13" version="1">MLFTRVCRLFPSMSVSLALPRRGVISSGMASDPSEITRFDFLVVGGGSGGLAGARRAAELGAATAVIESHKLGGTCVNVGCVPKKVMWNAAVHAEYLHDHGDYGFETGDVRFSWETLKAKRDAYVSHLNRIYRNNLDKAKIQTIQGYARFINDAEPTVEVNGRKYTAPHILIATGGQPSVLSDAEVPGASLGITSDGFFELETLPKRSLVVGAGYIAVEMAGILSTLGSKTSLIIRQTGVLRNFDAFISANCTKELQNSGIDLWKNSQVKSVSKTDKGLEVTVVTKDPEKKNDEEKISTIQGVDCLLWAIGRQPNTGGLNIGEMGVDTDERGHIIVDEFQNTSRSGIYAVGDVCGRALLTPVAIAAGRKLAHRLFEGKKDSKLDYTCIPTVVFSHPPIGTVGLTEEEAIKTRGKENVKIYKTSFTPMYHAITSRKSQCIMKLVCVGKEEKVVGLHMQGLGCDEMLQGFAVAIKMGATKADFDKTVAIHPTSSEEFVTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQW6</accession>
    <name>A0A3P9BQW6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catenin alpha-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004541134.1">
        <property type="nucleotide sequence ID" value="XM_004541077.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQW6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012322"/>
    <dbReference type="Ensembl" id="ENSMZET00005012754.1">
        <property type="protein sequence ID" value="ENSMZEP00005012322.1"/>
        <property type="gene ID" value="ENSMZEG00005009239.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477413"/>
    <dbReference type="KEGG" id="mze:101477413"/>
    <dbReference type="CTD" id="1495"/>
    <dbReference type="GeneTree" id="ENSGT01030000234543"/>
    <dbReference type="OrthoDB" id="6376697at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034334">
        <property type="term" value="P:adherens junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043009">
        <property type="term" value="P:chordate embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001894">
        <property type="term" value="P:tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000006">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000007">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000008">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000011">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000012">
        <property type="entry name" value="Catenin alpha-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF24">
        <property type="entry name" value="CATENIN ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00663">
        <property type="entry name" value="VINCULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="863"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="907" mass="100291" checksum="474E1E405931E7B9" modified="2019-02-13" version="1">MTSNTAPNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTSNKGPSNKRKGRSKKAHVLAASVETATENFLEKGEKIAKESQFLKDELTAAVEDVRKQGESMRQASGEFAEDPCSSMKRGNMVRAARALLSAVTHLLVLADMSDVYKLLVQLKLVEDSLAKVRNAGTEQDLGIQYKALKPEVDKLNAMAAKRQQELKDVQHKDQMAAARGVLQRNIPLLYTASRACLQHPDVAAYKANRDLIYKQLQSAVSGISNAAQATPTGDSALSQSGGGGELADALNNFDKQIIVDPLAFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNSVRQALQDLLSEYMGNAGRKDRSDALNTAIDRMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMAASQLESLCPQVINAALALAAKPNSKVAQDNMDLFKEQWEKQVRVLTDAVDDITSIDDFLCVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVVHVVTSEMDNYEPGVYTEKVLEATKLLTDTVMPRFTEQVESAVEALSANPSQPVDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSSCKQDLHAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGLDSAMSLIQAAKNLMNAVVSTVKASYVASTKYQKNKGMEALNMPAVSWKMKAPEKKPLVKREKQDDGQTNRVKRSSQRKHVNPVQALSEFKAMDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BR73</accession>
    <name>A0A3P9BR73_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-2B adrenergic receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alpha-2B adrenoreceptor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547118.2">
        <property type="nucleotide sequence ID" value="XM_004547061.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BR73"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012450"/>
    <dbReference type="Ensembl" id="ENSMZET00005012889.1">
        <property type="protein sequence ID" value="ENSMZEP00005012450.1"/>
        <property type="gene ID" value="ENSMZEG00005009366.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101484392"/>
    <dbReference type="CTD" id="151"/>
    <dbReference type="GeneTree" id="ENSGT00940000161915"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004938">
        <property type="term" value="F:alpha2-adrenergic receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051379">
        <property type="term" value="F:epinephrine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071881">
        <property type="term" value="P:adenylate cyclase-inhibiting adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000488">
        <property type="entry name" value="Adrenoceptor alpha 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000100">
        <property type="entry name" value="alpha-2B adrenergic receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF130">
        <property type="entry name" value="ALPHA-2B ADRENERGIC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="61"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="238"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="525" mass="56886" checksum="6D0AA78233B2F05E" modified="2019-02-13" version="1">MASVQDSGCSMELSGWNSSVSGSGSSVPCNQSVLNPAPYSPEATAAFATAITLMVIFTIVGNIMVIIAVLTSRSLRGPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFKSLWCEIYLALDVLFCTSSIVHLCAISLDRYLSISRVTYGRQRTPKRIKAAIVVVWLISAIISFPPLLSLNKSEGGDKGSERGPQCQLNDERWYILYSTIGSFFAPCLIMILVYVRIYQIAKQRTRCPPGEPRKDGVGCATPSQPPRHVQANGKDEEESTPPSSNKTSNARPPTLAITPSPAPAESQTSPNPTPNNLLQPPSPSPAVPTATEVDTSSQVPSTPSTVPQSATKTKVEGKKGKRLQKKKADNNNADSSSTESDMEHSHGGGRGSTSMPGSPAGGGIHSPASVKHYRDMIATSKGARLVPGRKSKTDNNPGAARRKAMVNREKRFTFVLAVVIGVFVVCWFPFFFSYSLQAVCPETCTIPGPLFTFFFWIGYCNSSLNPVIYTIFNKDFRKAFKKILCRSTKGTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRF5</accession>
    <name>A0A3P9BRF5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">DDB1- and CUL4-associated factor 1</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Serine/threonine-protein kinase VPRBP</fullName>
        </alternativeName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex. Interacts with DDB1; the interaction is direct. Also forms a ternary complex with DDA1 and DDB1. Interacts with NF2 (via FERM domain). Component of the EDVP complex, a E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1. Interacts with DYRK2; the interaction is direct. Interacts with RAG1; the interaction is direct. Interacts with LLGL1 and LLGL2. Interacts with histone H3. Interacts with ESR1 and LATS1; probably recruited by LATS1 to promote ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation. Directly interacts with TET1, TET2 and TET3 (via C-terminus). Interacts with CEP78; promoting DCAF1 localization to centrosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VPRBP/DCAF1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012509"/>
    <dbReference type="Ensembl" id="ENSMZET00005012948.1">
        <property type="protein sequence ID" value="ENSMZEP00005012509.1"/>
        <property type="gene ID" value="ENSMZEG00005009371.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005874"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990244">
        <property type="term" value="F:histone H2AT120 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000055">
        <property type="entry name" value="DDB1 and CUL4-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033270">
        <property type="entry name" value="VPRBP/DCAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129:SF4">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129">
        <property type="entry name" value="VPRBP PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0804">Transcription</keyword>
    <keyword evidence="19" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="213"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="983"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="983"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="28">
        <location>
            <begin position="1015"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00063313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00071147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00078221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1487" mass="163781" checksum="328B9142AD3F3043" modified="2019-02-13" version="1">MSSADEEPSAAIVAALTSALSSAVSAAMAVAMAVDSKADLSALLDEWEEAQRGPTEQLVSVLNRISELIEKEMGEYHKADPDPFDDRHPGRADPDCMLGQLLKMLFMNDDFTNALLDTYIMTSREHSLNTAACRLLQNICPGLETAVVFQEKEGLAERLFGWAREAERPLCVYATGLLARAMSNQEVAANYREENAQLVPVMIKRLHELQSQEATSHFSATHTSENLPQDSQAETAQTSGVTTAQQDPMEMEARNERAGEGSRTTSNTKPTSLLGSAQKNGGRSSSSARLLPGFVYQVAPDSASRETEDMQGGRGGGGGKKWAIKENERKAKQKLNITNSSDRSGEDAERTEASEQPASTSSWSEMSSLMIGTDFRLSPLSPAMEQRLILQYLTPLGDYQELLAVFMQLDTRSLLMNYIDLRQTNNVQLTFDALLYLASLLLHKKFAAEFIAHGGVQKLLEIPRPSMAATGVSLCLYYLAYNQDAMERVCTLPDGVLSDTVSYALWLLESSHASGVCHATMFFSISFSFRAVLQLFDQQDGLRRLVNLISTLEILNVGSELSRLSDDQVFSSRQTAKHTCMALRRYFEAHLAVKTEQVKQSLHASDGGIVIPQQPFYKAYSYTREQIIEMMEFLIECGPPQLHWEPVEVFYKLACVPLMLQLISTACDWRTYFGRSDTVRYALDILSILTVVPKVQLVLAETVEVQDEARSPVSTVGMSIILGVAEGEVFVNDAEIQKSALQVIINCVCAPDQSLNSVGAFAVTPLKPLLHPQQPPTPHNRVLAHMWQVVQNNNGIKVLLSLLSVKMPITDADLIRALACKALVGLSRSSAIRQIISKLPLFTRSHIQQLMKEPVLQDKRSEHVRFCRFAAELTERVSGKPLLMGTDVSLARLQRANVVAQSRITFSERELLVLIRNHLVAKGLQDTANTLVKEANLPAATLCPNPSPSCVTPPPSASVVPRTCRLAGGIAARIASHVGASPVSSGASVSPCPSSSRPLAPPHPSCSSASTSAHPTPPPPPLPHPSPQGQGPYPLGRILFSRERPVAPCSSGKKLRALKQKSDHGAFIQTPAMKKQLERHLPSPPTLDSIITEYLREQHARCPNPVTTCPPFSLFTPHRCPEPKQRRQASPNFTARLGARVLYPKYGGVDRACLDRHLIFSRFRPMSVFHEGDGDESGFTCCAFSACERFLMLGTCSGHLKFYNVLSGEEAANYTCHTSAITHLEPSRDGKLLLTSASWSVPLSALWSMDGVFIKKNSFADDHYVEFSKLSQDRVIGTKDQVANIYDIQTGQKTLTLNDPGLANNYKRNCATFSPTDDLVLNDGVLWDVRASRAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNSNATIMYGAMLQADDEDDAMDQQMKGPFGSSFRTFDATDYKPITTVDVKRNIFDLCTDTKDCYLAVIENQDAVGLDTVCRLYEVGRQKLAEEGDDDDQVSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSV0</accession>
    <name>A0A3P9BSV0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bardet-Biedl syndrome 9</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004560188.1">
        <property type="nucleotide sequence ID" value="XM_004560131.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004560189.1">
        <property type="nucleotide sequence ID" value="XM_004560132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSV0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013043"/>
    <dbReference type="Ensembl" id="ENSMZET00005013492.1">
        <property type="protein sequence ID" value="ENSMZEP00005013043.1"/>
        <property type="gene ID" value="ENSMZEG00005009799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482162"/>
    <dbReference type="KEGG" id="mze:101482162"/>
    <dbReference type="CTD" id="27241"/>
    <dbReference type="GeneTree" id="ENSGT00390000000803"/>
    <dbReference type="OrthoDB" id="10262646at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028074">
        <property type="entry name" value="PHTB1_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055364">
        <property type="entry name" value="PTHB1_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055362">
        <property type="entry name" value="PTHB1_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23339">
        <property type="entry name" value="PTHB1_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14728">
        <property type="entry name" value="PTHB1_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23337">
        <property type="entry name" value="PTHB1_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 GAE" evidence="4">
        <location>
            <begin position="436"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 platform" evidence="5">
        <location>
            <begin position="530"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="6">
        <location>
            <begin position="639"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 C-terminal helix bundle" evidence="7">
        <location>
            <begin position="744"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="872"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="703"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="995" mass="109965" checksum="E0F75D01F5187DBE" modified="2019-02-13" version="1">MSLFKARDWWSATLGEGEEFDQGCLCVGDVDNSGTGHDKVVVGSYMGMLRIFSPHASKTIEGGQADAQLLEVQLQNAIIQVELGKFVSCSELLHLAVLHPRKLSVYSVSGTAGNVEHGDQYQLKLVYEHNLQRTACNMTYGTFGGVTGHHSLCIQSMDGMLMFFEQDSYSFGRFLPGFLLPGPLTYNPRTDSFLTVSSARELESYKYETLAVATEAGSRQDPNLPLKTGGKRLTPDWVFVLGEQALDLCVPSFSHASSHIFILGERNIYCLRDNGQIHFMKKLEFNPSCFLPYASVTDGTTNLLLGNHTNMLLVYQDVTLKWASQLSFIPVAVRVANFLDVKGVVVSLSSDGQLLCSYMGTDPSFFSTPKVDAREADYEQVEAEMKKLQKFIREATRTQDILPKTDSEDDLCITTTVSSSMDNPSQALIHDINGLPVPSVTVQVKVKASSVVKSSKLSIGVQPPLAVTQEQFVLEAMGVGSSKVVVFSAFLNGHYPPADLTGDITVSYSSPTELNPKGVPKVLQSRFNLPPSLVCVACPPPKATKFKITVDTNQPPVDLSSIFREFSAKSEDKDGNSLAFQLLSGAKVTVLASKTSQRYRIQSDSFEDMWLVVKELVHRFDQHFSKLGIKDFKKSFSGPLPLEEYFLSVDKHFQLRVSAQKYQDLLSERAVQFRAIQRRLLTRFKDKTPAPLQNLDTLMDATYSQVMALAEAAEENRALLEEAFVRLRSATHLLVLLLSLWQGLTPDQTSILEATLLPLLQDTPQLGWEESCDAAVSHLLRTCLSQNPKDQATSLAQTGGSVLGLPSDTARLKKHITLLCERIGKGGRLTLASEANVQVPAQVQNLAVPGGVEPIAELAGDGEEIEVPQEATKFIKKKQPSKKTKKEKEKKEVSKEPSEASVKEEEPIKETKKEKKESSKEKKESKKESTKEPKEEAKKESKKESSSSKEKKESSKEKKEKEKEKEGKEAGDKKVSRRSSVKVKEKKKEPEAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BT24</accession>
    <name>A0A3P9BT24_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">5'-nucleotidase</fullName>
            <ecNumber evidence="3 9">3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the pyrimidine 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="3 9"/>
    <dbReference type="RefSeq" id="XP_004560191.1">
        <property type="nucleotide sequence ID" value="XM_004560134.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BT24"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013113"/>
    <dbReference type="Ensembl" id="ENSMZET00005013561.1">
        <property type="protein sequence ID" value="ENSMZEP00005013113.1"/>
        <property type="gene ID" value="ENSMZEG00005009846.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482837"/>
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        <property type="component" value="LG11"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:5'-nucleotidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd07504">
        <property type="entry name" value="HAD_5NT"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.150.340:FF:000001">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.1000:FF:000032">
        <property type="entry name" value="Cytosolic 5-nucleotidase 3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.340">
        <property type="entry name" value="Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006434">
        <property type="entry name" value="Pyrimidine_nucleotidase_eu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01544">
        <property type="entry name" value="HAD-SF-IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13045">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CYTOSOLIC 5'-NUCLEOTIDASE 3A"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF05822">
        <property type="entry name" value="UMPH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01128">
        <property type="entry name" value="C1.4:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008389"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012643"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU361276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="331" mass="37632" checksum="6E230C45A67031AC" modified="2019-02-13" version="1">MDRTAVVKVGAAASASVCALFGGVVLAQYIVAKKKRAGKKTRIIEMMPQFEKTTVHMKDHGKVEDIICGLIKGGASKLQIITDFDMTLSKFSVNGKRCPTCHNIIDNCKLVTEECRSKLLALKNKYYPIEIDPQLTMEEKYPFMVEWYFNSHRLLVEQRLERDKLPEVVRESDVALRDGFEQFFDRLQQHNVPVFIFSAGLGDVLEEIMRQAGVYHPNVKVVSNFMDFDENGILKGFKGELIHVYNKHDGALRNSEYFKQIKEYSNIILLGDSLGDLSMADGVNNAENILKIGFLNDKVEERLDKYLDSYDIVLVKDETLEVPNAILQKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVX7</accession>
    <name>A0A3P9BVX7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004563890.1">
        <property type="nucleotide sequence ID" value="XM_004563833.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVX7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013786"/>
    <dbReference type="Ensembl" id="ENSMZET00005014255.1">
        <property type="protein sequence ID" value="ENSMZEP00005013786.1"/>
        <property type="gene ID" value="ENSMZEG00005010379.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471711"/>
    <dbReference type="KEGG" id="mze:101471711"/>
    <dbReference type="CTD" id="6540"/>
    <dbReference type="GeneTree" id="ENSGT00940000157478"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11496">
        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF111">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="620" mass="69666" checksum="32DD7A5C1E0EC822" modified="2019-02-13" version="1">MKGQSNDMENTSKVEASNGHSRPLDIVPSTEEKMTERGQWGNKVEFILSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFACGIPVFFLETALGQYTSEGGITCWRKICPLFEGLGYGSQVIVALLNIYYIIVLAWAIFFLFHSFTWDLPWASCNNSWNTNSCMPLQKGNTSINHHENTTSPVIEFWERRVLRISSGIDHIGSLNWDLALCLAFAWVICYFCVWKGVKSTGKVVYFTATFPYVMLLVLLIRGVTLPGASIGIHFYLYPDINRLSDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYNNNCYRDCVALCFLNSGTSFVAGFAIFSILGFMSNEQNVPISEVAESGPGLAFIAYPRAVTMMPFSPLWACFFFIMIVFLGLDSQFVCVESLVTAVVDMYPSVFRRKNRRELFILAVAIVSFFLGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFQTVCIGWVYGADRFYDNIEDMIGYRPGPAIKYCWLFFTPATCFGTFAFALIKYSPLKYNNDYVYPLWADGIGWILALSSMLCIPLCMAFKLYNTPGTLRERFVLLSTPSTELPKTKQEQEALHAIFAADGESLHQKAPPSRDGYVPVGEKESHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXB8</accession>
    <name>A0A3P9BXB8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Podocan</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_024654627.1">
        <property type="nucleotide sequence ID" value="XM_024798859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXB8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014628"/>
    <dbReference type="Ensembl" id="ENSMZET00005015111.1">
        <property type="protein sequence ID" value="ENSMZEP00005014628.1"/>
        <property type="gene ID" value="ENSMZEG00005010982.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160740"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF20">
        <property type="entry name" value="PODOCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018211323" evidence="6">
        <location>
            <begin position="25"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="7">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="586" mass="66195" checksum="F5A1D2CDD64C2D57" modified="2019-02-13" version="1">MAFLKHSILHALSVLLLAWVLVQCQASVEPEEEEEEEPTEETETATEVTKSEPEICPQDCSCTAERVVDCPGVNLIEFPAKLSEKTRQLSLQNNKIEEITVEHISHLHQLETLNLQNNWLTSDGLEDEGFEMLEQLAYLYLANNKLTLAPKVLPPSLVSADFAANQLTRIFPYTFGHKPKLRSVYLHNNKLTDAGLPEHMFNASDNLEILTMSSNFLRVVPKNLPPTLYRLHLKRNKLEKIPAGAFDSLPNLRELYLQNNLLSNEGMDNETFSQLSSLECLDLSNNNLSVVPKGLPRSLVLLHLEKNDIRSIPGDALTSARNLEYLLLHNNKLRSRSIHPAAFQGLKKLHTLHMHNNLLERVPRGLPRRAKTLMLLHNSISEIGRNDLTLLYTLIELNLSYNKLTSPKMQREAFRKLRLLETLDLSGNSLTSMPRGLPRSLHVLEIKNNLINSIPDGTLTKMEKLRKLILSNNQLKLNSVYQGAWMELTALTTLDLSGNLMTHIPADLPESLEYIYLQNNRISSIHGSAFEGTPNIKGIFLRFNPLSVDAVDESSFKYLSNLQVLDTGAGNPDLPIQKEEIEEEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0H4</accession>
    <name>A0A3P9C0H4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">X-ray repair complementing defective repair in Chinese hamster cells 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XRCC4 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004572864.2">
        <property type="nucleotide sequence ID" value="XM_004572807.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0H4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015669"/>
    <dbReference type="Ensembl" id="ENSMZET00005016174.1">
        <property type="protein sequence ID" value="ENSMZEP00005015669.1"/>
        <property type="gene ID" value="ENSMZEG00005011763.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101481251"/>
    <dbReference type="CTD" id="7518"/>
    <dbReference type="GeneTree" id="ENSGT00940000166544"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005958">
        <property type="term" value="C:DNA-dependent protein kinase-DNA ligase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033152">
        <property type="term" value="P:immunoglobulin V(D)J recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010165">
        <property type="term" value="P:response to X-ray"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22283">
        <property type="entry name" value="HD_XRCC4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010585">
        <property type="entry name" value="DNA_repair_prot_XRCC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053963">
        <property type="entry name" value="XRCC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053962">
        <property type="entry name" value="XRCC4_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053961">
        <property type="entry name" value="XRCC4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009089">
        <property type="entry name" value="XRCC4_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28559">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28559:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06632">
        <property type="entry name" value="XRCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21925">
        <property type="entry name" value="XRCC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21924">
        <property type="entry name" value="XRCC4_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50809">
        <property type="entry name" value="XRCC4, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRCC4 N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="XRCC4 coiled-coil" evidence="9">
        <location>
            <begin position="122"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="XRCC4 C-terminal" evidence="10">
        <location>
            <begin position="232"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="335" mass="37792" checksum="E84A46FD92F4E7DA" modified="2019-02-13" version="1">MHTSVREINLCSDTSYFLRVDWEGCNFSTGFQLLLTDGQDAWRGEVRGEVVCNEAEELEMPLERYIEDVEQAFTGRENSNTYNFTLTPNPPGHSSTLTLTYEKMQKDISFRLGCVLLKAVPEPAEAVRNLLIHSLQRGNNLQHHNQRLQEENERLRGEQQHITAELKRYIGGKEALEAELYSRFVLVLNEKKAKIRSLQQDVTKLEEMRSNDQRKKDSVKSGQTRGQDDGVEEDDYGGSTDEDPVETQSTPASSLESPTPGPLDESLSDLTDVAPSRKRRFRHLRAPEAAVKQPNPETSQRKRNDSPAGSSKHQTPRLSADAAASSAVEDLFEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0U2</accession>
    <name>A0A3P9C0U2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Solute carrier family 2, facilitated glucose transporter member 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fructose transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glucose transporter type 5, small intestine</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0U2"/>
    <dbReference type="Ensembl" id="ENSMZET00005016366.1">
        <property type="protein sequence ID" value="ENSMZEP00005015855.1"/>
        <property type="gene ID" value="ENSMZEG00005011909.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166173"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005353">
        <property type="term" value="F:fructose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070837">
        <property type="term" value="P:dehydroascorbic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001511">
        <property type="entry name" value="Solute carrier family 2, facilitated glucose transporter member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF130">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER 9-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="15">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="478" mass="53076" checksum="C4E25C80BD7BC851" modified="2019-02-13" version="1">MSPLSFLLHSVSIIWITFNNSLNLSPQYIQCFINNSWYDRYGEPPHPQMVTMIWSLIVSMFAVGGLFGAISVKFISDLLGRKKAMICNSFIAVLAAGFMLTSKNVNSFEMIIVARFLFGYSAGLGMNTHLIYLGEISPRKIRGIVTLTSATFTSLGKVSGRAFGLSEILGREDTWDILLSVAALFSFVQIVMLPFFPETPRYLLIEKGDDKACKKALQSLWGQGDYQQEMDEMLTEQAAIEAAPPVSLLQLLRDRTVRWQVITISTIYCCNQLSGMSTISTFTYDIFLEAGIPKKKIRYITLGLGVAEILTSLTCGLLIDLTGRRPLLFGGYGVMSACWIFVTVTLNLKDSSYWVPYITVSLMVVFIVFFCGGPGGATPTLNSELFIQSNRMASLVLTGLQGWFMFAVMGLVFPFLIDALSSYLFVLFASACMLGSLYTFFLLPETKGKTLLEISEEFKAITVCGKSFAEETRTETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C492</accession>
    <name>A0A3P9C492_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative monooxygenase p33MONOX</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the P33MONOX family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C492"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017093"/>
    <dbReference type="Ensembl" id="ENSMZET00005017639.1">
        <property type="protein sequence ID" value="ENSMZEP00005017093.1"/>
        <property type="gene ID" value="ENSMZEG00005012842.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000174372"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026759">
        <property type="entry name" value="P33MONOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28342">
        <property type="entry name" value="MONOOXYGENASE P33MONOX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28342:SF1">
        <property type="entry name" value="MONOOXYGENASE P33MONOX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15302">
        <property type="entry name" value="P33MONOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="100" mass="10958" checksum="B8BC46DBA491D14F" modified="2019-02-13" version="1">MGGNEGGGGDRWSFFGIRSVVQKSPTDPGSETSTSLQSYFGLQKSSTMDGTNTQVNLKVDDPTKFMPPKIEISDIEAKRQNPRPHKLKPRDMNVLTPSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C499</accession>
    <name>A0A3P9C499_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C499"/>
    <dbReference type="Ensembl" id="ENSMZET00005017482.1">
        <property type="protein sequence ID" value="ENSMZEP00005016942.1"/>
        <property type="gene ID" value="ENSMZEG00005012715.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153582"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000646">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="342" mass="39159" checksum="56635DF52B7C6AC6" modified="2019-02-13" version="1">MINHFQKLSRSTYISLHVADHVHFFWVCFDACTVNDLSKELDQGFCKVSLVVLGLCVQNVIHLDQHGARSQRSQEADKPHSRKGEKTYSCDECGKDFACSKHLKTHQLIHSEVKVYNCDECGRSFTDPRNLKTHQLIHSEVKVYNCDECGRSFTDPGNLKRHQLIHSEVKACNCDLCGKSFAHTGSLKTHQLIHSGVKAYTCDLCGKSFAQPRNLKAHQFVHSGVKPFTCDQCGKTFARSKTRNKHLRIHTGHDVWCCDQCGKLFTTHARLQNHKFTHTEERPYKCDLCEKTFKSPRELKCHKRVHTGEKPYKCRHCDRSFSHPGFVYSPLCSSCFVTFSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4F8</accession>
    <name>A0A3P9C4F8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein NLRC3-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="9" key="2">
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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        <source>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="CENTROSOMAL AT-AC SPLICING FACTOR"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>A0A3P9C538</accession>
    <name>A0A3P9C538_9CICH</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Alcazar R."/>
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                <person name="Baroiller J.F."/>
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                <person name="Hofmann H.A."/>
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                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
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                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
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                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="Ensembl" id="ENSMZET00005017710.1">
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    </dbReference>
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        <property type="entry name" value="DUF4549"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33331:SF13">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING 162"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 162"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF15082">
        <property type="entry name" value="DUF4549"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4549" evidence="1">
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            <begin position="1"/>
            <end position="113"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017164.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="114" mass="13668" checksum="2029E6638BC15DE5" modified="2019-02-13" version="1">KVKQMEAELWSHLSALKAEIEESVLPPKDISFFRVEREHALRRGLQSQADIMQRELESCLSSEYTPDSLPLLLHQFFTDRSYHLAQIRYLLMLRWRRFCHHASVIEKLYPHYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C541</accession>
    <name>A0A3P9C541_9CICH</name>
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        <submittedName>
            <fullName evidence="20">ST14 transmembrane serine protease matriptase</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="gene ID" value="ENSMZEG00005013050.1"/>
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        <property type="component" value="LG11"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
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        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Transmembrane serine protease 3"/>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
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        <property type="entry name" value="Spermadhesin, CUB domain"/>
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        <location>
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        </source>
    </evidence>
    <sequence length="853" mass="94824" checksum="6D51E341BB96F6F0" modified="2019-02-13" version="1">MWLPFCLLTVFFVLFLHQGHSKHERIDFLTQKEKAPPKSKTGIVIGVVVALLILSAVAAFLIWFFVCERSVRKSELSLTEYAALSKQLRQSVPVFSGRMTLVNQPYDQNLEDTNSPEFQALAEKLETVLGNYLKRDPILEKYYTKSVVTAFSEGVKAYYWSQFNIPHSDLEMIPDVSEERILDALESGIRQSRSASAPDVKISQVTASLTDSRMARDPRANDCFYRLEADTNPQNFSSPGYPTGYPPKSRCQWQIRASEENVIVVNFLYFYIEDDCSDDFVYIYDSLSPDDSQAITKKCGQRPPSNPLEVVSSNNIMLINFIAETDAQKPGFQAAYSVIPKADVTCGGSLSQKQGNFTSPLYPSFYPPAKDCKWTITVAPGSKVRLRFTMFRMKEPGVDTRLCHKDYVEIMGNKYCGEVASLSLTSDTNVLVVNFHSDRSHTDKGFSAEYSSYDPSNPCPDRFACTNGLCIDQKLKCDGWNDCGDMSDERQCNCDKDQFACSNGMCKPKLWVCDHVNDCGDGSDEKICGCAQNEFQCGNGVCLPQSVQCDDKQDCKDGSDEVGCKTGDICTDYSFKCKSGVCVNKVNAECDRVQDCSDNSDETICDCGTRPYKLNRIVGGQNAELGEWPWQVSLHFSTHGPTCGASIISNTWLLSAAHCFVTSNSDNNPSSWLSYSGMQNQYSHDNVQSRKLKRIIPHPLYNQMTSDYDIALLELSEPLQFANTIQPICLPDSSHVFPAGMSCWVTGWGALREGGQAAQILQKALVKIINDSVCDVVTEGQVTSRMLCSGYLSGGVDACQGDSGGPLVCFEESGKWFQAGIVSWGEGCARRNKPGVYTRVTKLREWIKQETNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C592</accession>
    <name>A0A3P9C592_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Si:dkey-238d18.5</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004541631.3">
        <property type="nucleotide sequence ID" value="XM_004541574.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C592"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017219"/>
    <dbReference type="Ensembl" id="ENSMZET00005017765.1">
        <property type="protein sequence ID" value="ENSMZEP00005017219.1"/>
        <property type="gene ID" value="ENSMZEG00005012926.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101485679"/>
    <dbReference type="GeneTree" id="ENSGT01150000286924"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46484:SF1">
        <property type="entry name" value="SCHWANN CELL MYELIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46484">
        <property type="entry name" value="SI:CH211-171H4.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018203239" evidence="8">
        <location>
            <begin position="23"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="136"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="233"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="496" mass="55076" checksum="B1852351DFBFF958" modified="2019-02-13" version="1">MDALQQLVFFMCICFKATQTESSWTVDVPSSVEGLLGSCVVIPCSYNYPDIAAHTFTGIWRIDDQVIYHPTESNTMEKYRGRTKLLGDLSKKNCSLMIENLQQSDGGPFFFRIELEGPNKFSYSNNKVSISMIGEPNPTDFFVQEEVKEGQTVSAFCSVSHSCPTNPPDFHWSHSGEQHFQTQNLQNGQWKATSTLTFHSDRTDNNKPLRCRVTYHGGKQREPSKTIKVKYAPVNVKVEYQSDVNEGETAHLKCSSDANPVSSYEWHSESGALLNKGQTYTMSNVSRNSEAVYCTAVNEEGRVKSSTVQLNVLYAPDIETYSKCSSYNGIVKCDCIVQSRPPSTVHFVLGDRVLPSSKVEKNGSVTTGTLQTDFGSFKFVHCLANNTLGNSNLTLFLPVNDNMQNIFIASGAGVIVLIILIAIGVGVVKKCRGQSDGTPKSDLSTTRSDRPAEPPRYAQTKRKENYEDVHCNDIYGNDSVYGNTETDWDESVYANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C5G5</accession>
    <name>A0A3P9C5G5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Myelin transcription factor 1-like, a</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYT1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C5G5"/>
    <dbReference type="Ensembl" id="ENSMZET00005017841.1">
        <property type="protein sequence ID" value="ENSMZEP00005017294.1"/>
        <property type="gene ID" value="ENSMZEG00005012992.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155671"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000001">
        <property type="entry name" value="Myelin transcription factor 1-like, a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013681">
        <property type="entry name" value="Myelin_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF20">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08474">
        <property type="entry name" value="MYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="CCHHC domain"/>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
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                <person name="Penman D.J."/>
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                <person name="Tan F.J."/>
                <person name="Williams L."/>
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                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
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                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
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                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
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                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
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                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
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                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
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                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7I4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018228"/>
    <dbReference type="Ensembl" id="ENSMZET00005018819.1">
        <property type="protein sequence ID" value="ENSMZEP00005018228.1"/>
        <property type="gene ID" value="ENSMZEG00005013690.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157905"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="6">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="4 5">
        <location>
            <begin position="162"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="178" mass="19574" checksum="AC22BFAF3A857D10" modified="2019-02-13" version="1">MKGLRFLNCQCSCRITRVTKERMSANASSSIPGTAAVVFSKPGRPLCTKSDEVRLAEEASKKYGSPAPTIFSKVIDKSIPADIIYEDEKCLAFRDISPQAPVHFLVIPRIPIPRISEAKDDDAELLGHLLVVAKNVAKQESLTEGYRVVINDGKHGAQSVYHLHIHVLGGRQMKWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C8K0</accession>
    <name>A0A3P9C8K0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Family with sequence similarity 81 member B</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM81 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8K0"/>
    <dbReference type="Ensembl" id="ENSMZET00005019007.1">
        <property type="protein sequence ID" value="ENSMZEP00005018412.1"/>
        <property type="gene ID" value="ENSMZEG00005013822.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004985"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029619">
        <property type="entry name" value="FAM81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420">
        <property type="entry name" value="PROTEIN FAM81A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420:SF5">
        <property type="entry name" value="PROTEIN FAM81B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="180"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="256" mass="28191" checksum="A17B66EFFF7B69B9" modified="2019-02-13" version="1">DYTNLYSQNHLRFYAAAPPLPSQRPGPPPASRSTLSRERSSSAGTPSAGTSGVLGFRAPPDVLEGRLRSQDRPLAVLLEQALRIKEEVTAGLQSSHGSVQIEALSRKLLENHILTITRIVKQLSMGIQELEKEMAQRDSVTSGVAHAVQNMDQKNTAGVGDLRGRVARCDSSIAKLSADVSFREQQVIRLQREVRELSEAVNGQLKELEDKVGKKRMHADKGLAEKELREQLSKTLQGHKDFKLKGITDCPFTFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C909</accession>
    <name>A0A3P9C909_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004541563.1">
        <property type="nucleotide sequence ID" value="XM_004541506.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C909"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018386"/>
    <dbReference type="Ensembl" id="ENSMZET00005018980.1">
        <property type="protein sequence ID" value="ENSMZEP00005018386.1"/>
        <property type="gene ID" value="ENSMZEG00005013800.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466487"/>
    <dbReference type="KEGG" id="mze:101466487"/>
    <dbReference type="CTD" id="393789"/>
    <dbReference type="GeneTree" id="ENSGT00940000166341"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024643">
        <property type="entry name" value="Hist_deacetylase_Gln_rich_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364:SF11">
        <property type="entry name" value="HISTONE DEACETYLASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45364">
        <property type="entry name" value="HISTONE DEACETYLASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12203">
        <property type="entry name" value="HDAC4_Gln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase glutamine rich N-terminal" evidence="12">
        <location>
            <begin position="67"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="222"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="434"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="524"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="623" mass="69865" checksum="2CD5A71A9456EB2D" modified="2019-02-13" version="1">MLQTIYEGESSFSITEGRVGHQQFPNPSKMHNVNNSVDIKPDVPLAVEPLSPLDLRTDLRMLGPGSDPGLWERQLQQELLLIQKQQQIQKQLLISEFQKQHEKLTRQHQAQLQEHLKLQQELQAMKQQQELAEKERRLEQQQQQQSQQEKEQEKHRREHHISSLSLRGKERSRESLTGAVASTEVKQKLQEFLLSKSAKDSASNGANHSFIQHPKLWYTSSHHTSLDQSSPPLGGTSPTCQYTLPSPVESKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPMLKRRDGNIMTPYKKRALELMDSTPTNSAPGSGPSSPIGASSALGAENGPSSLPTTTKTERWPSQPRLFRPEGSVPMLSLYTSPSLPNISLGLSTASSPISAAMGLKDRSTEIKHGLPGHLLGPVPLQTGLESKVSPSHQALLQHLLQKEQMRQQKILSSGQGSMSSHSQSPLAMKDRPSSTRPKLPKHRPLNRTQSAPLPQNTLAQLVIQQQHQHFLEKQKQYQQQVHINKLLSKSIEQLRQPSAHLQESEEEQEEQHREEVEGMQEDRLPPGGVIRKHTLSSSSSGSSSELPDTHYGVIKVKEEPADSEDEALTNQSLESEQSTYLHQVKGRLVIRAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C925</accession>
    <name>A0A3P9C925_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C925"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018549"/>
    <dbReference type="Ensembl" id="ENSMZET00005019149.1">
        <property type="protein sequence ID" value="ENSMZEP00005018549.1"/>
        <property type="gene ID" value="ENSMZEG00005013927.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162662"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="270"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="81827" checksum="0D2B80910E3A8D8D" modified="2019-02-13" version="1">MMRCCGLLTNSVCLSVPLKSIEVELEVRDHVATVVSTLNYENKENKPLEAVFVFPLPGDTAVCHFSAKIGQTQIVAEVMEKQKAREEYDDALSSGQQAFLLEESDQSPDIFSLSVGSLPPGESASIRLEYVAELAVQADDGLRFCLPAVLNPRYQPRGGLSSVGLVPYSLSFSARVSSPRPISKVESNCSLDPLQDLNTDQTQATVKLAAGHKFDRDVELLIYYKDAHQPTAVVEAGQASAEPGSLMGDPVVMVSLYPEFPQSAMSSCGEFVFLMDRSGSMSNTRIRSAKDTLLLLLKSLPMGCYFNIYSFGSCYEHIFPKSVEYSQQTIKESLKKVEQMEANLGGTEILEPLKYIYSQPCIPNQPRQLFVFTDGEVRNTKEVIDLVKKNSGSHRCFSFGIGEGASSALINGMAKEGGGHAQFITGTDRMQAKVMQSLRFALQPVVVDISVTWDLPKEVSVTVLSPPITALFQGQRSLIYAQLTGQVGAAAGCVMVKYSLAGHPSENQLHFSLRPAEDTGLTVHRLGARTLIRSLEMEEREHRGQQGGGVKEKVVHLSVQSGVSCSFTAFIAVNKDNSKVIQGPLVRRNIPTASEFFPIAKLKVSHRSEAKMVQYIELDSTLYVQLLFHLCTLSLSAAVQLQPPRDPLLQLVFLQEASGYWRLDPALATALGKISKEMEKSNNEVWATILALIWLHAFKMDAKDEWELLAMKAASWLRAQNAPCVSECVDAGNVLLGSSVKKEALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9W0</accession>
    <name>A0A3P9C9W0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Symplekin scaffold protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004559165.1">
        <property type="nucleotide sequence ID" value="XM_004559108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9W0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018877"/>
    <dbReference type="Ensembl" id="ENSMZET00005019484.1">
        <property type="protein sequence ID" value="ENSMZEP00005018877.1"/>
        <property type="gene ID" value="ENSMZEG00005014146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479833"/>
    <dbReference type="KEGG" id="mze:101479833"/>
    <dbReference type="CTD" id="8189"/>
    <dbReference type="GeneTree" id="ENSGT00390000017045"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="111"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="879"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136618" checksum="6687BA2BF1AD9228" modified="2019-02-13" version="1">MDFSSQEGDSEAPAVIDMTTSEKVVELLNQAALIPTDEKLNVLKQVQELIINKDPSLLDNFLDEMIAFQTDKSIEVKKFVIGFIEEACKRDNELLLRLIANLNMLLKDESVNVVKKAILTLTQLYKVTLQWLVRSKAVSEMQEACWDLVTQMKGDVLALLDSENDGVRTHAIKFTESLIITLSPRTADSDVPKRQEGDISLDKVPTDHSYIHYDELCEEGKTALEKLLKFMVHPAISSINLTTALGSLATIARQRPMFMSEVVQAYETLHANLPPTLAKSQVSSVRKNLKLHLVAVLKHPCSLEFHGQISILLLDLGMPQSEITRSTPVPREQRKRPRQEQYTEGKKVKMEPALIEDDEDKEEPAPLSVPKPAAVPVAQSAIDLTAEFLHPLLTPENVANLVLISMVYLPDIMPASFQATYTPVESAGTDAQIKHLARLMATQMTAAGIGPGLEQCKARGEGAVKEENDDDVGSKDILIKRKVPAVMVGQAISVVGGYAEKALPEVPAAVVKRLPEPILPSAQTKMTGASGRKKVFRLSDIVQQLSDSQIENLTSKAVKRILHSEKAIAQSGMSHVRVKLLSRLVTQFDGMMKADVLDFILDDIRTRSDLAFSLLYQEYNTYLSQLPSGLLDSYDHCLYTLLSGLQEKPEQRDGLFTKLVLEAPIITESALEVIRRYCEDESRVYLGMTTLKELIVKRPSRQFQYLHVLLDLSSHEKEKVRTTALAFLKRMYEKDHLRDYIEKFALNYLQLLVHPNPPSLLFGADKDTEVAAPWTEETVRQCLFLYLSLLPLNHRLVHELASVYTEAIADIKRSVLRAIEQPIRGMGMNSPELLLLVENCPKGAETLVTRCLHILTDKVPPSPELVERVRDLYHKRVPDVRFLIPVINGLEKNEVIQALPKLIKLNPIVVKEVFNRLLGTQHSEGSSSVSPLTPGDLLIALHNIDSIKCDMKSIIKATNLCFGEKNVYTSEVLAVVMQQLMEQNPLPMLLMRTVIQSLTMYPRLGGFVMNILSRLIVKQVWKYPKVWEGFVKCCQRTKPQSFSVLLQLPPAQLTSVFERCPEMRAPLLQHVHSFTPHQQAHIPGSIMAVLEANKKPEPKPAEPVVETDVTDQELQMEAAPAPSVVEEAPKEPETTVQLEPVTQKDEEEPMEQEESEPAIQEETLNISQVESEAETPVPEPEPVEEPMEESQPEPSEEPEPEKDTEADDVTKEAGNTSEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCN9</accession>
    <name>A0A3P9CCN9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Si:ch73-15b2.5</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004548741.1">
        <property type="nucleotide sequence ID" value="XM_004548684.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CCN9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020053"/>
    <dbReference type="Ensembl" id="ENSMZET00005020700.1">
        <property type="protein sequence ID" value="ENSMZEP00005020053.1"/>
        <property type="gene ID" value="ENSMZEG00005015053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465733"/>
    <dbReference type="KEGG" id="mze:101465733"/>
    <dbReference type="GeneTree" id="ENSGT01030000234571"/>
    <dbReference type="OrthoDB" id="27593at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF2">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="211"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="428"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="537" mass="61281" checksum="CBB1E837A8E8079D" modified="2019-02-13" version="1">MSQSPTTEGREMLCQGFSLENSRAEHTGGLDRGSGSLNKPENCSFPLDISPALRLVALRRTWDLKKNHLAAHKLKIFLPPGLQEDNSSSSAQCDPDKSKEGEENVIGEELQSERFQSKYIHIFPLYQDYCLQTMKDDLHRLKDGLLSELITPKYLQSLQTPMTRAESPQRSARHATPRSQPIRVTPSTLWQDLDEVKASGLLSSLTAREIRLQETMFELIGSEASYLRSLGVAVNHFYKSQELKQTLSQTEHHILFSKIQHVMVASEKFLTDLESRLGENVLIPQVGDVVLQHCKHFQTLYVPYVTNMMYQEALINEKLQHNRIFLYTLKKLESDPVCQRKTLKSFLVLPFQRITRIKLLLESILKLSEPDSDSVSNLKKAIDAIHEIVTECDKGVRKMKQIEELVCLEMLLDFGKVKSVPMVTSKRFLVHHGALKQLTKESAYNLRMSFVGVYLHLFNDLLIVSMKKDERFKVMDHAQFPEHVSVQPVKTEVLGLPSYSFLLHLSKTQTGHPTAMIIATDTRSEKEAWMKALSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CE67</accession>
    <name>A0A3P9CE67_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">14 kDa phosphohistidine phosphatase</fullName>
            <ecNumber evidence="5">3.9.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohistidine phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein histidine phosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits phosphohistidine phosphatase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(pros)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47964"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="3.9.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(tele)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47960"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:10719"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="3.9.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the janus family.</text>
    </comment>
    <dbReference type="EC" id="3.9.1.3" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004538507.1">
        <property type="nucleotide sequence ID" value="XM_004538450.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CE67"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020540"/>
    <dbReference type="Ensembl" id="ENSMZET00005021209.1">
        <property type="protein sequence ID" value="ENSMZEP00005020540.1"/>
        <property type="gene ID" value="ENSMZEG00005015205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477977"/>
    <dbReference type="KEGG" id="mze:101477977"/>
    <dbReference type="CTD" id="29085"/>
    <dbReference type="GeneTree" id="ENSGT00390000002738"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.20.20:FF:000001">
        <property type="entry name" value="14 kDa phosphohistidine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.20">
        <property type="entry name" value="Janus/Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007702">
        <property type="entry name" value="Janus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038596">
        <property type="entry name" value="Janus_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258:SF10">
        <property type="entry name" value="14 KDA PHOSPHOHISTIDINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258">
        <property type="entry name" value="JANUS-A/JANUS-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05005">
        <property type="entry name" value="Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143724">
        <property type="entry name" value="PHP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="128" mass="14511" checksum="81EE26226BA71519" modified="2019-02-13" version="1">MCTQTKAAALMANIPQADIDPSGVFKYVLIRVHSREEGDDSEVDIVRGYGWAEYHADIYEKVAEELERDGHLDCECIGGGRIKHDPQAKKIHVYGYSMGFGRANHAVTTEKLKVRYPDYEVTWDNEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CE76</accession>
    <name>A0A3P9CE76_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Tripartite motif containing 66</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004543232.1">
        <property type="nucleotide sequence ID" value="XM_004543175.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004543233.1">
        <property type="nucleotide sequence ID" value="XM_004543176.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024658151.1">
        <property type="nucleotide sequence ID" value="XM_024802383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CE76"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020339"/>
    <dbReference type="Ensembl" id="ENSMZET00005020978.1">
        <property type="protein sequence ID" value="ENSMZEP00005020326.1"/>
        <property type="gene ID" value="ENSMZEG00005015236.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005020991.1">
        <property type="protein sequence ID" value="ENSMZEP00005020339.1"/>
        <property type="gene ID" value="ENSMZEG00005015236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466579"/>
    <dbReference type="KEGG" id="mze:101466579"/>
    <dbReference type="CTD" id="9866"/>
    <dbReference type="GeneTree" id="ENSGT00940000159240"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05502">
        <property type="entry name" value="Bromo_tif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000123">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037372">
        <property type="entry name" value="TRIM66_Bbox1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915:SF7">
        <property type="entry name" value="TRIPARTITE MOTIF-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25287">
        <property type="entry name" value="zf-B_box_Trim66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="15">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="1005"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="1092"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="372"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="730"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="817"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="137"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="775"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1236" mass="137768" checksum="3CBE306430918962" modified="2019-02-13" version="1">MEKSCSECTEPTLAQSLCTLCNKWLCYQCTDVHQHLRTPNTSQYMESHQQQRPSATQFPELHQRGSSSLPPTGQGPGSYPWSLLMCHSHRQEPLELFCESCDLLCCSSCHLSSHKNHRVVQIGKALQDQQWLFESLMVQVEEKRSAVENSAKQIEERLHGVKIAHRKAENQIKMAKMIMMNELNKRANLLIEQLEKIAEGFQQRLEDQLQGAIEICGQLDHIQKFITWAMTHHCTSPVLFSRALISLQMQQLLEASHHSDSWSPVKIKFNWDASYWTKQISCLGQLTVEGGNCAYPPGLACSSIMRPQPITCLTLPPVFHRGREPGCGYQACCEPQMCCLHGIHSQPDLPSLDKSQLDTTLYNSSCAQPAHISASQHQNQQIQRFWDQESSLQRPPPASPVPNRRHNQLSRSRASASQPQAADSQPHSQSKSYLSHHQHRKEVLPNTQARLSAERGRPNRRRGKLSTSRSLQQELSYTALERDPMSEENRVETHRVEETCGQIAVAERREMLDQELQQGRRVQSPVQQQQLLLCLSGVRKEQKRTNSALTVKDHRDARPESCIRFPGGIDQRSTSLEVTVTAHECVSDVQNSSRLSTGSVCSRRKRRSQSIPTELAAPSASPYAERPTGWACSLEAGAANKYYVLDPRQRRASDGVLCVAKETSTEPPLMSYKTEPDHPITYVNEEIGFDANKKCSFSSNSNSSDVQNDSARPRVPVICLERLKILVSQLPPHGRRQSDPLPASGTDKSETLPQGITGESETSGATRVLAAPKRQTCNESTAQSDCSDSNIGVPVPRKESTLLSADSEYVAPSFYELDLDSDSDPRSVSEEAVISQADSDPQLDSDASPDSDPNAPSSSEAELECRAEQKSAEMGLCGDSEPSLEYEADPESDAGPDGRGLDADTESGDAETESDIQPVYDPTFQGETDSDVVSDQPPDSQGSVASELDVDSEPELTTDDPQPLRSDLDEEIGPGQRPLLIANPVVPGDTEEVQTEQDSTELESEDFCAVCLIGGDLLCCDRCPKVFHLSCHIPPLPTFPSGDWVCTLCRDVLHQGVEYNGDNERASGENASANLLSPCDQKKCERLTLLILSNILSAPFQEPVSPLARHYYQIIKRPMDLSVIRAKLSKGNTQCYSSPDEFVADMYLMFRNCAKFNYPDSEVAQAGRSLEAFFTSNLKEVFPGRVFPMAEVDSDSDEYDEAYRTTESGFPWPERREQCHRKRKRRQSLKSRRHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CE94</accession>
    <name>A0A3P9CE94_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane protein 63B</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CE94"/>
    <dbReference type="Ensembl" id="ENSMZET00005021006.1">
        <property type="protein sequence ID" value="ENSMZEP00005020354.1"/>
        <property type="gene ID" value="ENSMZEG00005015259.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157084"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF38">
        <property type="entry name" value="CSC1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018163138" evidence="10">
        <location>
            <begin position="17"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="119"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="239"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="11">
        <location>
            <begin position="432"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="750"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="831" mass="94558" checksum="811FFB9B9570F43C" modified="2019-02-13" version="1">MLRALIVTMAITSSHACSGQENCSADGDGEYKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLVLLFVFSILRKVAWDYGRLALVTDADSVASAMHSETPDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDEEIREKCGEDAVYYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGTNLLWLHTTFAFMYLLLTVYSMRRHTSKMHYKEDDLVKRTLFINGISKYAEESQIKQHFEQAYENCTVLEARICYNVAKLMALNAERKKTERSKKFFTDLMAKEHVPTMINPKPCGHLCCCAIAGCEEEEAVSYYTKREAKLKEEYRKEKEKVHTKPLGMAFVTFQNEAMTAIILKDFNACQVQGCRCRQEPRSSQFSEVLHVHNWSVSYAPDPQNVRWEHLSLGGISWWIRCFVINCILFILLFFLTTPAIIISTMDKFNVTKPVEYLNNPIVTQFFPTLLLWAFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDVFFRWLFDRKFLADAKVRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAADRRNVKRHQAYEFQFGAAYAWMMNVFTVVMAYSITCPIIVPFGLMYMLLKHLVDRYNMYYAYLPSKLDKKIHSGAVTQVVAAPILCLFWLLFFSTVRTGFDTPTSMFTLVVLIVTIVVCLSHVCFGHFKYLSAHNYKIDTKENDVDAVENGRPARPSSSPTTKSQQQQQMYIAQVLQDPNSDEPGGGSSEEDRGSSQDEEMLNGGNSINEADFQSGEDSLIANEVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEQ0</accession>
    <name>A0A3P9CEQ0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ephrin-A1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the ephrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004541328.1">
        <property type="nucleotide sequence ID" value="XM_004541271.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEQ0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020514"/>
    <dbReference type="Ensembl" id="ENSMZET00005021172.1">
        <property type="protein sequence ID" value="ENSMZEP00005020514.1"/>
        <property type="gene ID" value="ENSMZEG00005015381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479095"/>
    <dbReference type="KEGG" id="mze:101479095"/>
    <dbReference type="CTD" id="494151"/>
    <dbReference type="GeneTree" id="ENSGT00940000159919"/>
    <dbReference type="OrthoDB" id="8774972at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10425">
        <property type="entry name" value="Ephrin-A_Ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000017">
        <property type="entry name" value="ephrin-A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034252">
        <property type="entry name" value="Ephrin-A_Ecto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019765">
        <property type="entry name" value="Ephrin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF19">
        <property type="entry name" value="EPHRIN-A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01347">
        <property type="entry name" value="EPHRIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01299">
        <property type="entry name" value="EPHRIN_RBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51551">
        <property type="entry name" value="EPHRIN_RBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018172749" description="Ephrin-A1" evidence="11">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ephrin RBD" evidence="12">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="234" mass="26834" checksum="0C9689B3DEF54DC3" modified="2019-02-13" version="1">MDVVCLLCLVLTIGSWFASAERHSVYWNSSNANFQWNEYTVEVRINDYLDIICPHYTHDEVPSHAAERYVLYMVEREDYEVCKPHSFDQLRWECSRPFAPHAPEKFSEKFQRFTPFTLGKEFRQGESYYYISKPMHHHGKDCLRLRVDVVGHKGSGKNHYDKSKARETEKILGGEKVNFPATGGVHNPSNHLPADDPAAMEPNVQRSVGNSAAQLISRSLLFALIPVLLALMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFY4</accession>
    <name>A0A3P9CFY4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rho guanine nucleotide exchange factor 12</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004543798.1">
        <property type="nucleotide sequence ID" value="XM_004543741.2"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005020939"/>
    <dbReference type="Ensembl" id="ENSMZET00005021626.1">
        <property type="protein sequence ID" value="ENSMZEP00005020939.1"/>
        <property type="gene ID" value="ENSMZEG00005015720.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464277"/>
    <dbReference type="KEGG" id="mze:101464277"/>
    <dbReference type="CTD" id="562455"/>
    <dbReference type="GeneTree" id="ENSGT00940000157662"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030218">
        <property type="term" value="P:erythrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23069">
        <property type="entry name" value="PDZ_ARHGEF11-12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000006">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000033">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000072">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015212">
        <property type="entry name" value="RGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872:SF3">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45872">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09128">
        <property type="entry name" value="RGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="773"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="569"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="706"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1148"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1418" mass="158413" checksum="E86C0738FF5D9723" modified="2019-02-13" version="1">MSDTQPSFTDRFPKKANRTSSILSKDHPPDKKPKSERNSLPSNEFDPTEALVVQKSGSSSVLPEGKPESCGLVQRCVIIQKDENGFGLTVSGDNPVFVQLVKEDGAAMRAGVQTGDRIIKVNGTHVAHSNHTEVVKLIKSGSYVALTVLGRPPGLAQIPLPEAEPDMSLSSPNSPAPRRPCSPQDSILPIQQPWDEKADILEAMKEEYSRNPSPKLLKDIQEAEKHIPQLQGQLPKAIGTTQEIVPSDDADEDAFVPKGENNADLFWTRTPISRIFGPSSPDSQCPREFSCPSPKTTPRNSYNSFHSPETEDTTDLDALSPTTVSSPSSSRLVSQIIGAEDDYFDSDQEQTNGQCNSFNSIELLKSRPAHLAAFLYHVISQFDPAPVLCYLYADLYKQTNSKETRRVFMGLHNFFIDRGANLKVGVPESVSADLDRRRTELIPEEINRQHVQTLQDSLLPDIQKNLEDFRQKRSMGLTVAEAELGRLDQERVRDRGTLERERSYAENIIAKIDDILVTTQLTEEEKCTTMQYVIYTYMKHLGVRVKEPRSLESKRLRISFLPMIKRGNKTEKEREEKVKKVPKNNKFNIRVPQRRPSRIESSGGTTQEGRPRPQKQMSQPALSTSDYKESSRLKGSQSSEGPELIHSMSVNSSSPISATYSSDTSRDADMGGTPIFGPCRVSEILPSDSLDGLPYSASQFDPLYNLDQLPEDDRESDRTHEGTPKALRRLEGLGAADIQSEDDQGTDSECDPPNWQHLVRPEVLAGLRPHEIKRQEVIHELFYTERAHVRMLKVLDNVFYQKLTKDSILPPADIKNIFSNLEEVLQLHVNISDQMAAVRKRNDSSVIDQIGDDLLSWFSGGEEEKIKQAVGTFCSNQPFALELIKTKQKKDSRFTSFILEAESNRQCRRLQLKDIIPVEMLRLTKYPLLLDNIVKYTDNAEEKEKVKQAADCCRKILSHVNQAVKESEDKQRLEDYQRRLDLSSLKQTDNPMILELKNLDLTKKTMVHEGPLSWKVNKDKTIELYTLLLEDILVLLQKQDERLILKCHSKNLSGTADTKHIFSPIIKLNTVLVRSVATDNKSFFVLSMSENGAQIYELMAPTVSDQRTWQRLITQRAEAMKVKPHSVIPLPQTVGERDGVEIITTGVSRLSRDTDRTSTGSTQSTDKESSPVCRSALQTSLPGSNPFEGVKTEEEKEEEEEGFVDPELSYPVAEDCRGASFSMFPSRADEALKTLAALKHVLVTQLMSQEAAEQTKRSTGARLLRTTSLRTPIDSRARVTVHNGSEKTGSQTDDLAQDLGSGDTGFFDSTDDYAAYLVLEGYGGPGESSTDDDILATTTGKQLSTSQGCAADSGINLRFSSTSQAGSLSSFSRQVLSHLRNLQANLNYLKEVEAKYNSLIQQRPERSAADTHGNKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGU2</accession>
    <name>A0A3P9CGU2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">40S ribosomal protein S23</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004548837.1">
        <property type="nucleotide sequence ID" value="XM_004548780.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGU2"/>
    <dbReference type="SMR" id="A0A3P9CGU2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021500"/>
    <dbReference type="Ensembl" id="ENSMZET00005022210.1">
        <property type="protein sequence ID" value="ENSMZEP00005021500.1"/>
        <property type="gene ID" value="ENSMZEG00005016148.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465735"/>
    <dbReference type="KEGG" id="mze:101465735"/>
    <dbReference type="CTD" id="6228"/>
    <dbReference type="GeneTree" id="ENSGT00550000074784"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="143" mass="15849" checksum="8FCEB4CB8C40B815" modified="2019-02-13" version="1">MGKCRGLRTARKLRNHRREQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CH15</accession>
    <name>A0A3P9CH15_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Unc-13 homolog B</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005021437"/>
    <dbReference type="Ensembl" id="ENSMZET00005022145.1">
        <property type="protein sequence ID" value="ENSMZEP00005021437.1"/>
        <property type="gene ID" value="ENSMZEG00005016059.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154929"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20859">
        <property type="entry name" value="C1_Munc13-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08394">
        <property type="entry name" value="C2A_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04027">
        <property type="entry name" value="C2B_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000031">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037302">
        <property type="entry name" value="Unc-13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF8">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="9">
        <location>
            <begin position="455"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="561"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="11">
        <location>
            <begin position="1240"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1368"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1540" mass="175553" checksum="4F47FDB3B0ED5C27" modified="2019-02-13" version="1">LTMLCVFITFNTYVTLKVQNVKSTTITVRGDQPCWEQDFMFEINRLDLGLIVEVWNKGLIWDTMVGTAWIPLKSIRQSEEEGSGEWLFLDAEVLMKADEIYGTKNPTPHRVLLDTRFELPFDIPDDEAQYWTGKLERINRMGIHDEYSLQEDVQSHPLPFAASQCSLDDQDSAVDDRDSDYRSETSNSLPPRYHTTAQPNSSMHQYPMGPRPQHRPDGCTDSAHSFDLDYRDPRGSSPVESSRFGSSGNLSQTSSQLSETGHESTGGSELEESFHSYHSTGFHPSTNGQLRTNGTNLSINGHSVVSEREMDRLSPDKRQDIKSDTTAETGSPKLHRPSFHDDDGPPLPFSQSRLHWMKAITKVRVQLREEDSDPSVYMDCLEIGGSGLYGIDSMPDLRKKKPIPLVSDVSLVQARKAGIASAMAARSSIKDEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHEKCQELLNADCLQRAAEKSSKHGAEDRTQNIIMAMKDRMKIRERNKPEIFELIREVFVISKAIHAQQMKTIKQSVLDGTSKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQSIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQINVEIKGEEKVAPYHVQYTCLHENLFHHSTDVLGQGVVKIPEARGDDSWKVYFDDVGQEVVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAFYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSSYRNHFPASSKDRLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVRDCVKACLNSTYDYIFNNCHELYSRQYQPNKEELPLEEQGPSIKNLDFWPKLIMLIVSIIEEDRNSYTPVLNQFPQELNVGKVSAEVMWTLFAQDMKYAMEEHEKHRLCKSTDYMNLHFKVKWLYNEYVKELPVFKGVVPDYPSWFVQFVLQWLDENEEVSMEFMNGALERDKKDGFQQTSEHALFSCSVVDIFTQLNQSFEIIKKLECPDPRVMAQYSRRFSKTIAKVLLQYSAMLTKNFPSYIDKEKIPCVLMNNVQQLRIQLEKMFESMGAKQMDTEACDLLNDLQVRLNNVLDDLSRTFGNSFQTRISECMRQMASLLYQIKGPVNANNKNQVEADSDNMLRPLMDFLDGKLTLFATVCEKTVLKRVLKELWRIVMTSLEKTIVLPQGNDTFGAQILSAAKELGQLSKLKQYFHAGGNGLKKAFLEKSPELSSLRHALSLYTQTTDTLIKTFVTTQQAQGSGVDKPIGELCIHIELYTHPKSGERKVTVKVVGASDLKWQTSGMFRPFVEITMIGPHLSDKKRKFQTKSKNNSWSPKFNETFHFVLGNQDGFECYELQACVKDYCFGRADRVVGLVVLQLRDIMEKGNCACWCPLGQRIYMDDTGLTALRILSQRSNDDVAKEFVRLKSETRSAEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CIK7</accession>
    <name>A0A3P9CIK7_9CICH</name>
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        <recommendedName>
            <fullName evidence="3 9">Sigma non-opioid intracellular receptor 1</fullName>
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        <alternativeName>
            <fullName evidence="8 9">Sigma 1-type opioid receptor</fullName>
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    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
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        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ERG2 family.</text>
    </comment>
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    </dbReference>
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        <property type="term" value="P:lipid transport"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
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    </dbReference>
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        <property type="entry name" value="ERG2_Sigma1R"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
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    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="Conte M.A."/>
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                <person name="Galibert F."/>
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                <person name="Greuter L."/>
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                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
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                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
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                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
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                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004564229.1">
        <property type="nucleotide sequence ID" value="XM_004564172.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9CKL2"/>
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    <dbReference type="PANTHER" id="PTHR16231:SF0">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="183"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
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    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="183" mass="20374" checksum="8BA0B6FE98DED13D" modified="2019-02-13" version="1">MAELTENMVVLLSALANKDCRKLCHRVVDSLCGREPPHRGDYSATWSLQEWLQLLDSLTALFRLAVVNNISDEVVLSQLSDVSSSQAEVVLSVLRAREEEIRCALLDRTNSISSATLQDFDWQLKLALSSDKISSLHTPLLSLSLDVRENGVLRPVTLEMNRDELGMLISSLESANKVVLQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CR79</accession>
    <name>A0A3P9CR79_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain containing 1</fullName>
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    </protein>
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        <name type="scientific">Maylandia zebra</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
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                <person name="Jaffe D.B."/>
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                <person name="Nikaido M."/>
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                <person name="Penman D.J."/>
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                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="257" mass="29305" checksum="DB0F5E4C27821C32" modified="2019-02-13" version="1">MEQRENYSSLHEFTEEPRPGANRLVPQYSDGSQGLKQGVKCLRSKTSLLILIGFLASICGNIVLAVLLISRPVPTAPLESSSSSALGLKSMQRRYIQLCEDYTALGQGCSKTVKQCRECPEGWLHIGNQCYYFSNDRLDWVRSRDSCEEMGSHLTILHTIEQHDALEKEAKRIGGFYYHYWIGLSDIETEGEWKWVDNTTLEHKYWDQASSEPDNHHTGGEHGEDCATLDSHSKTWFDVPCDHIYKRICQMDAIQLN</sequence>
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    <accession>A0A3P9CTD9</accession>
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            <taxon>Cichlomorphae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <location evidence="4">Secreted</location>
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        <text evidence="1 4">Belongs to the intercrine beta (chemokine CC) family.</text>
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    </dbReference>
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        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
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        <property type="entry name" value="C-C MOTIF CHEMOKINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
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        <source>
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    </evidence>
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        <source>
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</entry>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_024802228.1"/>
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        <property type="nucleotide sequence ID" value="XM_024802229.1"/>
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        <property type="nucleotide sequence ID" value="XM_024802230.1"/>
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        <property type="gene ID" value="ENSMZEG00005018897.1"/>
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        <property type="component" value="LG4"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ICAM_N"/>
    </dbReference>
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        <property type="entry name" value="ICAM_VCAM"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771:SF9">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE 5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03921">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018094765" evidence="2">
        <location>
            <begin position="17"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="211"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="326" mass="35661" checksum="698CFBFB8F519799" modified="2019-02-13" version="1">MFFFIFIAWIGKPVSTSCPLEISPPSVVVRYQGSFSANCTSLSNQTDGMGWESPYGGVDLTKGVTSLLLRIDSVPVWELEPMCFVNLHDGDQCTKVLPVTVYKMPDSASLKNVRTVEESRQFAIQCDVVSVAPARNLSVVWHKGNKILSSQTFEESSPSPVSKSSVLTLTAHRDDDGAEIWCEAKLNLWPKEQRPPPVRSEAHTLTVLYQPTFISASNETLDLPAGKNILSCNATGNPLPSYHWQFPQAAQETYKDQDVNYPILTGPFEFPGVYTCTASNSQGTVTKYFTVNKPPGIGPGAIAAIAIAAIVFVICTLGVIHRKCKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CU23</accession>
    <name>A0A3P9CU23_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450, family 2, subfamily N, polypeptide 13</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024654345.1">
        <property type="nucleotide sequence ID" value="XM_024798577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CU23"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025532"/>
    <dbReference type="Ensembl" id="ENSMZET00005026361.1">
        <property type="protein sequence ID" value="ENSMZEP00005025532.1"/>
        <property type="gene ID" value="ENSMZEG00005019058.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:112429820"/>
    <dbReference type="GeneTree" id="ENSGT00950000182879"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11026">
        <property type="entry name" value="CYP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF177">
        <property type="entry name" value="CYTOCHROME P450 2J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="495" mass="56258" checksum="D9FE67AB61AC40F2" modified="2019-02-13" version="1">MWFSNFVLSTEGVLLSFFFILLIAYYFKNRNPRNFPPGPFALPLLGNLQFIGKKHLHLYFAELAEVYGNVFSFCFGRDKMVMISGYKMVKEALVTQADNFVNRPYSALADRFYSGPTEGLFMSNGGKWKAQRRFALSTLRDFGLGKNRMEQCICEEIRYLQEEIEQEKGKLFSAAGLFNNAVSNIVCQLVMGKRYDYSDHNFQLMLKYLSETLQLEGSVWGQLYDSFPGVMKLLPGPHNKMFSYFDIVKDFIAQEIKSHKEDLDHNNPRDYIDAFLIKMENLNESDLGFTETNLVMCSADLFLAGTETTATTLLWALVFLIRNPDIQEKVQAEIDNVIGQTRQPSMADRPNLPYTDAVIHEIQRMGNIVPLNGLRIAAKDITLDGYHIPMGTSVLPVLTSVLFDKTEWETPDTFNPGHFLDADGKFVKREAFLPFSAGKRMCLGESLAKMELFLFFVGLLQKFTFSVPDGVELSTEGVSGITRVPEPFKVHAKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CW08</accession>
    <name>A0A3P9CW08_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the heterodimeric DNA structure-specific endonuclease complex MUS81-EME1. Part of the heterodimeric DNA structure-specific endonuclease complex MUS81-EME2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_014269312.1">
        <property type="nucleotide sequence ID" value="XM_014413826.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CW08"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026575"/>
    <dbReference type="Ensembl" id="ENSMZET00005027432.1">
        <property type="protein sequence ID" value="ENSMZEP00005026575.1"/>
        <property type="gene ID" value="ENSMZEG00005019813.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480192"/>
    <dbReference type="KEGG" id="mze:101480192"/>
    <dbReference type="CTD" id="80198"/>
    <dbReference type="GeneTree" id="ENSGT00390000005498"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000001">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="331"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="97"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="236"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="620" mass="69238" checksum="98708358911419E0" modified="2019-02-13" version="1">MPATEPVRLGRKRALPSCPNPLFLKWLTELRDEAKEKGLKIQYTYQKAINSLNKYPLPLKNAKEAKILQNFGDGICKILDEKLQRYYRENGADASIHALPKGAPPPGRSDNNIILAPSKKKNAAGDQGKDGGGDGGRKKKREYVPQKRSGGYAVLLTLYKETQVPGSKGYMFKMELQAEAQHLCDKSFTVPDLGSKYTAWSSVSTLIQKNLVIKTHNPARYSLTEGGLTLAERLASAEQTNTDGDREAVRSELEATEEDDPVVDLTGSDEDEEEKEENRIHPAERQPTVTEVSCDVDDVRSSGKPQDSQTTMTTSRKPNAECLLPGTYEIMLCVDFIETTGGSHHRKQELVKELQRNGVNFDIRKLNVGDFLWVAREKVAPVAGQLRAPVGRELVLDYIVERKRMDDLCGSIIDGRFREQKFRLKRCGLHKPIYLVEECGSAASHLSLPETTLQQAIVNTQVVDGFFVKRVQDVRESAAYLTIMTRFLTKLYQNRTLICRSRELEGDGGSDEEERGLPSCSLMSFAEFNHGAVKNKCQTVREVFARQLMQISGLSGDKAAAILEHYSTPHSLLTAYEQCTSEAEKEKLLSSIRYGKLKRNLGPALSRTVYHLYCTQGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZH5</accession>
    <name>A0A3P9CZH5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Negative regulator of ubiquitin like proteins 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZH5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027373"/>
    <dbReference type="Ensembl" id="ENSMZET00005028246.1">
        <property type="protein sequence ID" value="ENSMZEP00005027373.1"/>
        <property type="gene ID" value="ENSMZEG00005020417.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005028250.1">
        <property type="protein sequence ID" value="ENSMZEP00005027377.1"/>
        <property type="gene ID" value="ENSMZEG00005020417.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005028254.1">
        <property type="protein sequence ID" value="ENSMZEP00005027381.1"/>
        <property type="gene ID" value="ENSMZEG00005020417.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010557"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000058">
        <property type="term" value="P:regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14292">
        <property type="entry name" value="UBA2_NUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17062">
        <property type="entry name" value="Ubl_NUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039749">
        <property type="entry name" value="NUB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041207">
        <property type="entry name" value="NUB1_ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948:SF3">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12948">
        <property type="entry name" value="NEDD8 ULTIMATE BUSTER-1 BS4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18037">
        <property type="entry name" value="Ubiquitin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="485"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="604" mass="68142" checksum="FBF73D5B37C1536B" modified="2019-02-13" version="1">MAEQNLEAKLKNLLKQEKIQLWNPPYTEQGQQQGQQQGQQQGQQHMQELAERYAPLLRLPMSEVGGALESIRAQAVKRGRGNQTFRETSVATLELLLPRDAKKDPKVRTYLETRLDVSAQQVVDRVAEEHGLRSIKLILSGRTLSAERRLDEQGVKNHSKVMVLRVSDGELKQQLTEEEEERRSQEESVQRTQKGFQILSERDGSEDPDTTPFLEIADQKGNPLKIPPTEKKALILAMGFHEKGRALMKRKQHDNALCHLLQADQQFRKCGSALLSSVDNYAVLQLDIVWCYRALEALSCLEDGRSRLQRAEDCFLRCYGEQQERLLMIKGNTGREEVLFLRLYLLQSLLSYIEGSDSEARLQLSRVESLYARLRPDSEKMAQLMELGFSEREARLGLRASRGDLQEAAIHISTRRQEREELKQRERQKRRTRMEAISALMELGFSQRDAARALHHADGNVDRAYAILLDSSQDAQATNNNTEGGASPEMVEQLLYLGFERDSAEAALRLTGGDVQSATQLLLDNQGVLSPELLTPPSTSSSSSTPSSEEPSSASSSPEDSELVSEVLEDIAPHEEDYLDLTLEEESELISAMKAYLHREPAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D009</accession>
    <name>A0A3P9D009_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D009"/>
    <dbReference type="Ensembl" id="ENSMZET00005028284.1">
        <property type="protein sequence ID" value="ENSMZEP00005027411.1"/>
        <property type="gene ID" value="ENSMZEG00005020437.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
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        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
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    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="185" mass="21462" checksum="6859F3C211ABFEEB" modified="2019-02-13" version="1">MLLVLSHQLEYFFSVYYSLRFSSSPVGWLRFNNKCFMFKGKKNDIKGNWSYARSWCREQGGDLAVIDDQRLFTFPFSPTDFVANLLVENQYAWSDGVSPVLYTNWNDKEPNNANGVVRTLCFRLSLIDMHASRMFHGTWNDTKCDLEKPYICKKTSGTNSIRIELFFSFFLILDCSTSSVCVDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D0I9</accession>
    <name>A0A3P9D0I9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat domain 8</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540728.1">
        <property type="nucleotide sequence ID" value="XM_004540671.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D0I9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027874"/>
    <dbReference type="Ensembl" id="ENSMZET00005028762.1">
        <property type="protein sequence ID" value="ENSMZEP00005027874.1"/>
        <property type="gene ID" value="ENSMZEG00005020788.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464264"/>
    <dbReference type="CTD" id="123016"/>
    <dbReference type="GeneTree" id="ENSGT00940000156816"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21341">
        <property type="entry name" value="TTC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000300">
        <property type="entry name" value="Tetratricopeptide repeat domain 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028796">
        <property type="entry name" value="BBS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="513" mass="58177" checksum="C90C631D5AF508D3" modified="2019-02-13" version="1">MEVTMDPLFLAWSYFRRRKLQQCSDICTKILQDNPYDQDSSLLISEAAWSLKTRALTEMVYIDEIEVDQEGIAEMMLDESSIAQVARPGTSLRLPGTCHGGGPTPAVRPMTQSGRPITGFVRPSTQSGRPGTMEQAIKTPRTASTARPVTASSGRFIRLGTASMLTNPEGPFINLSRLNLAKYSQKPNLSRTLFEYIFHHENDVKNALDLAAQATEHAQFKDWWWKVQLGKCYYRLGLYREAEKQFRSALNHQEMVDTYLYLAKVYQRMDQPITALSLFKQGLDHFPGEVTLLTGIARIHEEMNNISSATEYYKDVLKQDNTHVEAIACIGSNHFYTDQPEIALRFYRRLLQMGVYNCQLYNNLGLCCFYAQQYDMTLSSFERALALVANDEEQADVWYNIGHVAVGIGDLTLAYQCFKLTLAFNNDHAEAYNNLAVLELRKGHIEQSKGFLQTAASLAPHMYEPHFNLSILSEKLGDLQSSYSAAQKSEDAFPEHVDTQQLLKQLRQHFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1C5</accession>
    <name>A0A3P9D1C5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gamma-crystallin M3-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024661215.1">
        <property type="nucleotide sequence ID" value="XM_024805447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1C5"/>
    <dbReference type="Ensembl" id="ENSMZET00005029309.1">
        <property type="protein sequence ID" value="ENSMZEP00005028405.1"/>
        <property type="gene ID" value="ENSMZEG00005021180.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005029311.1">
        <property type="protein sequence ID" value="ENSMZEP00005028407.1"/>
        <property type="gene ID" value="ENSMZEG00005021180.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:112436167"/>
    <dbReference type="GeneTree" id="ENSGT00940000163148"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000001">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000003">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF139">
        <property type="entry name" value="CRYSTALLIN, GAMMA M1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="184" mass="22435" checksum="5BB53B3E192D5939" modified="2019-02-13" version="1">MSNTGMNMRGKIIFYEDRNFQGRSYECMSDCSDMTSYLSRCHSCRVESGCFMVYDRPNYMGNQYFMRRGEYADYMSMMGMSDCIRSCRMIHMYRGQFRMRIYERENFGGQMYELMDDCDNIMDRYRMSDCMSCNVMDGHWLMYEQPHYRGRMMYLRPGEYRSFREMGMSGMRFMSMRRIMDSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1W2</accession>
    <name>A0A3P9D1W2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBCC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004569900.1">
        <property type="nucleotide sequence ID" value="XM_004569843.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004569901.1">
        <property type="nucleotide sequence ID" value="XM_004569844.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012779758.1">
        <property type="nucleotide sequence ID" value="XM_012924304.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1W2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028600"/>
    <dbReference type="Ensembl" id="ENSMZET00005029505.1">
        <property type="protein sequence ID" value="ENSMZEP00005028600.1"/>
        <property type="gene ID" value="ENSMZEG00005021325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473894"/>
    <dbReference type="KEGG" id="mze:101473894"/>
    <dbReference type="CTD" id="55171"/>
    <dbReference type="GeneTree" id="ENSGT00470000042284"/>
    <dbReference type="OrthoDB" id="427777at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031616">
        <property type="term" value="C:spindle pole centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051661">
        <property type="term" value="P:maintenance of centrosome location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051684">
        <property type="term" value="P:maintenance of Golgi location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039589">
        <property type="entry name" value="TBCC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16052:SF0">
        <property type="entry name" value="TBCC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="8">
        <location>
            <begin position="303"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="595" mass="66398" checksum="212D02B3CBBDFB8B" modified="2019-02-13" version="1">MEANGVSIWPRMEPFLLGALQVAPSSKLNLHYLRKMAIYVRTRNGCFPILSWPMWRHIACGKLQLPEDLAWLYFETYDLLIGHTPEERLEWAECLSQCSTKSELDQQRNKLSVDTLQFLLFLYIQQLNRVSLRTSLIGEEWPSHRTRSPSPSDRESKTSYQNKNWDDQAHLSFVQSHLAEILELLVEPGQLSQSGQALRDCQVSLDAVRSLGLLLEGSVCQGKAVQPIHRLLTKGPLETQAGYSSLTRSFPLHNLLSCLQRSLTLNPFGITACLHSGKKLAWAQQVEGAMKRAKIARNTHMAPPGSKMVLMSQVLKQTLAKTSDKLTGANIKIHRCADAFIYLLSPLRSVSVDKCRDSTVVLGPVETSVHIHSCQNVWVVCMAGRIVIGTSSRCTIHALTPTRPLLLPGNTDITLGPFHTFYPSLEDHMASVGLAVVPNLWDQPLLLVTEGLASHSLNTLSSPDPSCYRLLPPSEFHTLVVPFQMEGDTCEVPGGLPPSYQAALDEKKRRIQNWQKTVIEARLSKEQKQQFQELVEMKFHEWLLETGHRQELDSLIPPTIASVKDSDGAAADTNQVNDPKHMRTGQAVGQSSMAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3F4</accession>
    <name>A0A3P9D3F4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin family member 1C</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004574885.1"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005028737"/>
    <dbReference type="Ensembl" id="ENSMZET00005029645.1">
        <property type="protein sequence ID" value="ENSMZEP00005028737.1"/>
        <property type="gene ID" value="ENSMZEG00005021434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481352"/>
    <dbReference type="GeneTree" id="ENSGT00940000159295"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin-like protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinesin_motor_dom_sf"/>
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    </dbReference>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1C ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="839"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="987"/>
            <end position="1007"/>
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    </feature>
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            <begin position="1045"/>
            <end position="1235"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="1270"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="879"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1128"/>
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    </feature>
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            <begin position="1136"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
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            <begin position="1172"/>
            <end position="1189"/>
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    </feature>
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    <feature type="binding site" evidence="9">
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            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
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        </ligand>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="1290" mass="143418" checksum="5114F4E592EAD7D5" modified="2019-02-13" version="1">MAGASVKVAVRVRPFNSREIGRNAKCVIQMQGNTTCISNPKQPKDGAKNFTFDYSYWSHTTPDDPGFTSQTQVYKDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEPGQEGIIPQLCEDLFQRTGENTDPDLTYSVEVSYMEIYCERVRDLLNPKSQGTLRVREHPILGPYVEDLSKLAVTGFTDIRDLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKRRDQMTSLDTEKVSKISLVDLAGSERADSSGAKGTRLKEGANINKSLTTLGKVISALAEMQSSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRAKQIRCNAVINEDPNAKLIRELKAEVERLRNLLFSQGLQELLDNAVNNNNNINNGPGGVAGASPSPLQLALTSNGITPENGPAPPGAEPVSEGDTPADPDQLIEDGEEREEGESTENISKEEAAERLMETEKIIAELNETWEEKLRKTESIRLERESLLVEMGVSIKEDGGTLGVFSPKGTPHLVNLNEDPLMSECLLYYIKEGVTRVGQQDVDIKLSGQFIKEIHCVFVSETNEQGEVVVTLEPLVGAETYVNGKQITDAVILKQGNRIVMGKNHVFRFNHPEQARLERERSATMEQQEEPEDWNYAQKELLEKQGIDIKLEMEKRLQDVETQYRKEKEEADLLLEQHRLYADSDSGDDSDKRSCEESWRLISSLREKLPANKVQSIVKRCGLPSSGKRREPLRVYQIPQRRRISKDPKRVTMEDLRMQAVKEICYEVALGDFRHSRQEIEALSIVKMKELCRMYAKKDTNERESWRAVAQDVCDTVGIGEERSPAAEEGGGGGGGGGSGGSGGGETVEGGEKRGVYDLKAHIDKLTDILEEVKLQNNMKDEEIKALRDRMIKMESIIPVQDDDMNGEGGESPQRERDGDVDEDDDCPNHPEVRVQRLMDEDPAFRRGRLRWMKKEQQRLLNLQQQNITKKLRGQNQSQGQNTPTVPIHLPGTGRFIPPQECKLKFPFKSNPAHRLSWGPASAALQALGLGEGGGAGTDAGEQKENRGGEATGSPSPPPPPQGQLPGLLPLPFPAQPPRMRTPSPHRAWQQRNQGNQGGYHYNNQGNNQNQQRRYRRNSLDSSPQGNGSYDNDQHFSGGGNGGHQGRPRQRRGFSPGPGGERGGGGRGGGGGSRDGDRDRDGGFPYNQRQHHQYHHHHPYYNPHNAPFQPGPHPHPHYHSLPRSGAPALPADMLLGIVPPPGVWAFNTPPRMRRQFSAPDLKNNNNNNNKETPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D430</accession>
    <name>A0A3P9D430_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synuclein, alpha interacting protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004555820.2">
        <property type="nucleotide sequence ID" value="XM_004555763.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D430"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029114"/>
    <dbReference type="Ensembl" id="ENSMZET00005030032.1">
        <property type="protein sequence ID" value="ENSMZEP00005029114.1"/>
        <property type="gene ID" value="ENSMZEG00005021699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469855"/>
    <dbReference type="KEGG" id="mze:101469855"/>
    <dbReference type="CTD" id="9627"/>
    <dbReference type="GeneTree" id="ENSGT00390000001485"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.750">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="SNCAIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032027">
        <property type="entry name" value="SNCAIP_SNCA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22882">
        <property type="entry name" value="SYNPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22882:SF3">
        <property type="entry name" value="SYNPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
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    </dbReference>
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        <property type="entry name" value="SNCAIP_SNCA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
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        <location>
            <begin position="552"/>
            <end position="597"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
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        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
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    </feature>
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        <location>
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        <location>
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            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="930" mass="99698" checksum="4C77E86143F0CE05" modified="2019-02-13" version="1">MEAPEYLDLDEIDFSDDSVYSVTSLKSIPELSRRSDGQAEERQAPAINWSRSVSSHSSGGIKPTGIAEVHSKFRPVKRVSPLKHQPETTDAETDGKVQGQGLVLGEPVESSKDDPDKQTNASSDGQGGKAKSLGSSVGVVGGSNNPQALFGELEHYDLDMDEILDVPYIKSTQQMSTLPRVPHDKRSVTGSNIGGGTLERNRGGGLKNSTLTHNEPLSLGSSSSSQTQYCVLSPVKWSDLRKSKSMDPDLHHLHRSPGGGGYQPEMSSGLLSCSSSLSSFSDADKLLSARVYPDSQSQRPSVDPPGGPGLIFPLPGGSVSRQDSSKSWASASGGVGGGSRGFGGSGGAGGEVDEESKKNQNIINIVREGQISLLPHLAADNLELIRDEDGNNLLHISASQGHADCLQHLTSLMGEDCLNERNNQQLTPAGLGVKNGHLECVRWMVSETEAIAELSCTREHPSLIHYAARYGQEKVLLWLLQFMQEQAISLDEVDQNGNTAVHIAAQYGHLSCIQTLVEYGSNVTFQNQQGERPSQSAERQGHTTCARYLVVVETCMSLASQVVKLTKQLNEQASERMALQKQLQRLMEPNKAEGTPSRSPSSHQPSVEAWQEMMLTAEGTPGDGHWLVRQGGVGPDSVLRQLLGKDMSETLCPRERLPPAGGMSREGPGAPGGRRIGLVERRELKLARLKQIMQRSLSESDSDGYPPEEGKNQGAPPSNTLRPDRPSHLPITEEEPVSNHLQLMMKKHLPSSSSSTVERKLAFSLSGSKSVDSIGYNPSPTSSDPEATDGKTPDVPGDQDATNGQKVATSPKSALKSPSSRRKTSQNLKLRVTFDEQVHKSSSQEAEPTKVHQGKERTPTGSSESKRPFGTFRSIMETLSGNSNHNNNNSGGQSGSAVKVSTMQNSSGRKSESKSSPGGGAKGKSKTSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4Y7</accession>
    <name>A0A3P9D4Y7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Upstream transcription factor family member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005029414"/>
    <dbReference type="Ensembl" id="ENSMZET00005030342.1">
        <property type="protein sequence ID" value="ENSMZEP00005029414.1"/>
        <property type="gene ID" value="ENSMZEG00005021946.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18910">
        <property type="entry name" value="bHLHzip_USF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000051">
        <property type="entry name" value="Basic helix-loop-helix domain-containing protein KIAA2018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053252">
        <property type="entry name" value="EMT_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048064">
        <property type="entry name" value="USF3_bHLH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46970">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX DOMAIN-CONTAINING PROTEIN USF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46970:SF1">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX DOMAIN-CONTAINING PROTEIN USF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="859"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1364"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1474"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1560"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1609"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1712"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2024"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="895"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1474"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1712"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1769"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2028"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2038"/>
            <end position="2047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2067" mass="217266" checksum="5CDF1E874A80215B" modified="2019-02-13" version="1">MTLCLFVVLVERHRKEKINAGINRIGNLLPCSQALKQSKNMILDQAFRYITELKKQNDTMLLEGGDKVQAEEIRRLRRQLEELRRESAHYIELLKANDINPLEDPTIHWKGKQRCAKVAKVPPTHQLPKGIIVCSNGNGKFPAGKETSPGKQSSETLIIQPSSEASARLRVNGALLHVNNSSSTPALLPGSAAAPTQSTPSLRMIEQCVVEAPTVAPTLPPSVSYITLQIPAASTSMPQQAQPLTLAATSASQLPTEGSALPASTHPTKASEGCSWVTQDATIRTASYTAIPTSQALLRAGAAGSTQTTWTTLQMAGNTVKPSIRPAPTLLQPAIIPQPQPLPQPALVPQPQATVLPLLQTMQVLQVNPGGATASGVTVPQNTNNPSVVILQQASACPTQPVVREEITSQTPCQHFVIIQAPNQAATSAQNPQVGMVPAAIPTVSTQIPMTSTSVSAPSLQSVGGKQLVHILPRPVQPQASHPPQATQTSSSPPVPTTPQTITVNGQVFALQPVKTSDKASSQGGQSTLQLVQPTTSEEPTTNVALNSLGALSSLNQSISQGLPLNISSQNNGQPPPAPLSVLQQQPPAPASISGATLALPARQLQVPVTSGLVVSTSKPSAKRLRTALNMKRAAAKRTKAAKKKETSPPQPAVSLCAKPITATGESQTVQVTGSQILQSASVKVTDINSTCTTAVTAIDKAIGSVTTQQNTQKMIVSSSSSGPAVFSQSHPRDKTSVSASQSDSTFSHSNTSSITTAVTTVTATSIEPSVSSDLVDKSKVSPLSGSDSAVTKLSTAEAKHPITSTETSITQTKCTASTAASGQNRPVVTSAAASETLYTSSSVSTVCLTPVCTSSTTATAPLPFNKTTQQTSPCGSQGSASQDSLPCNKQESQATPSSSVSTTLSSSAPAFSAMHSSATTPTTSSDISKRNTAPRVTTQQTDVSTPNLSSCHPTEGKPPQAPRPNSEAQEEMQSTPAAKESLVVAPDIPPRKDFSLSQQVYTNLDDQTLEHSLTSSRQTDSPMSSGAGGGRGFSVASMLPQGHTIGASSGSFGTFTFTNEQAEMLALAMLEQDSPGRRSGGCSGENTASTNPTTATWEPTKTTPVSASKERGSAGQQAKVNKPIDPGTVKPAVEVSVRGQVGEGPVSASQNSSQSGTVASLSVNNLIRPSSSHQPYPGSPNLPGQQASTPSPAGTSSLISQASNNAHSPCSVGIGERQVKLISKRQAQDEVMLNTGKRPKPCPPSGNPVNHMDVKAADHNQMMVGQLPSSSSTVMTRINSEGGGPIFSANSFMSPVVRPADGHCPPQGPPEQNQPGVLHLPQGHQQHAVTQPGQHLGGNLYMKQQQQEQQRHHLYHLQHHLTQSDPAQRHSIHQRALQQQEQHVQKKRALVRGSQTGSPAGLQQKQHHLEKSGVQQQQHPSHQQQQAQPQHFRHQEKSCEAQAASSRGHHSNHLAQQDHLKVGSGQDHNAMQRMMSSRSLEQQQLISPPANPVSRSSDLACTPSRQERHRVSSYSAEALIGKSSTSGEQQRIGLHLQPGHSGAQEQPDLRGYLDTSRGKANIAHNPQSRLPSDHPGSADVQRVSECPPFKAMGGAGGAHQLSGFEAQVSRGSDMTSKPVPPSQRGPQGQQQPGFRMGPATDGRNRGGYSGAHPGSQGVQVGPALPREQDGCHQSFMQSLLSPHLPEQSNHQRAVQCCPPVSMEYSCVPGNSSGDIQAKTSSPSVPQTQKAPPMRLAEGNKGHISQVSSNMHPGPGVRSGLPHPPPPHSSSEPGRSSAPSRPPTAVSQHSRHIARDPQPTKLRPGDRPRSGTLRPSNPFEPEGHLPLPPGGGVLLSRPQSGGEARRSAIVRFMSDSAQVPSDNNLVPDQHLTQNFGFPFIPEGGMNPPPPINANSTFIPPVSQPNASRTPSLLPVEPQNTLTSFYPSYSPAAHPSLSSDVTLQYFPNQMFTSPSADKGSAPPLNNRFGSILSPPRPVGFGQASFPLLPEMPPMPIANSSGITPHISNFNLTSLFPEIATGMPTDGSAMPMSPLLSLSNTASADSGKQPNRPAHNISHILGHDGSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D775</accession>
    <name>A0A3P9D775_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="10"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D775"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030027"/>
    <dbReference type="Ensembl" id="ENSMZET00005030972.1">
        <property type="protein sequence ID" value="ENSMZEP00005030027.1"/>
        <property type="gene ID" value="ENSMZEG00005022389.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000917"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000013">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="11">
        <location>
            <begin position="71"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="221"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="357" mass="38530" checksum="CDC983ABBC58D478" modified="2019-02-13" version="1">VCILMCASFYYGGGLVSESGPAEAAHCVFVVDHSGLKLARTLNTLTLFISSVFERFYGLGSTSHRGMEDDILPLVKNIVPPLTSKKHKGQDGRIGIIGGCQDYTGAPYFAAISALKVGADLSHVFCTKDAAVVIKSYSPELIVHPVLDSPNAVEEIEKWLPRLHGLVVGPGLGREDLLLKTVIEKSKARDIPIVIDADGLWLVTQQPSVIQGYQKGILTPNFMEFTRLYEALPMDSSDYQRSVMQLSVAMGNLTLVLKGEQDFITDGSKVYSCNLEGSGRRCGGQGDLLSGSMGVLAHWAHAVPGPDNMNPSVVAAFGACSLTRQCNSQAFQRHGRSTTTSDMIQEISSAFKKLFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7D4</accession>
    <name>A0A3P9D7D4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho family GTPase 3a</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7D4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030585"/>
    <dbReference type="Ensembl" id="ENSMZET00005031547.1">
        <property type="protein sequence ID" value="ENSMZEP00005030585.1"/>
        <property type="gene ID" value="ENSMZEG00005022784.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157541"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000407">
        <property type="entry name" value="Rho-related GTP-binding protein RhoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="250" mass="28019" checksum="1A68CE26F640C93E" modified="2019-02-13" version="1">MKERRSCQKLSLKSSMDPSQSVKCKIVVVGDSQCGKTALLHVFAKDCFPELRPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVMKKWKGEIQEFCPNTKMLLVGCKSDLRTDLSTLVELSNHRQAPVSYDQVYGSNFLTLISMAKQISAPYIECSAQQSENSVRDIFHVATLACINKNNKNVKRSKTARASKRISHMPGRPDLAAVASDLRKDKAKSCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7I8</accession>
    <name>A0A3P9D7I8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Advillin</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7I8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030640"/>
    <dbReference type="Ensembl" id="ENSMZET00005031604.1">
        <property type="protein sequence ID" value="ENSMZEP00005030640.1"/>
        <property type="gene ID" value="ENSMZEG00005022391.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159587"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
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        <property type="entry name" value="VHP"/>
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    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0117">Actin capping</keyword>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HP" evidence="9">
        <location>
            <begin position="698"/>
            <end position="783"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="783" mass="88854" checksum="47B2455D75E02BF9" modified="2019-02-13" version="1">GNMDQTFRAVTRSPGIIIWRIEVILITQKVGNSLSYNIHYWIGSQSTQDEQGSAAIYTVQLDEFLGSSPIQYREVQDHESDTFKGYFKQGIIYKKGGVASGMRHTETNTYDVKRLLHVKGKKRVIAKEVEMSWKSFNLSDVFLLDLGKNIIQWNGPKSNRQERLKGMLLAQDIRDRERGGRAEIRVVEGEAESSSPQAMELMTETLGERTVALKDGPPDEAVDQEQKGQLTLYQISDADGQMRVTEVATRPLVQDLLNHDDSYILDQGGVKIFVWKGKKANKEERQAAMTRALDFIKAKNYPITTNVETVNDGAESALFKQLFQRWTVKDQTQGLGKVNTKGRIAHVTQEKFDASLMHAQPEVAAQERMVDDGTGQVEVWRIENLELAPMDPQWYGYLYGGDCYLILYTYLVNNKKCYLLYMWQGRHATQDELAASAFQAVSLDQKYNGEPVQVRVTMGREPRHFMAIFKGKLVIFEGGTSRKGSSEPEPPVRLFQVHGTDQFNTKTIEVPALATSLNSSDVFLLKSQTGMYLWCGKGSSGDERAMAKEVSSAISQNSPRGSEEIIAEGQEPIEFWELLGGKAPYANDKRLQQVVLDHKPRLFECSNKTGRFIVTEVTHFIQDDLSEDDVMLLDTWDQVFIWVGKDANEEERKEALTTSQEYLQTHPGDRDPHTPIVLIKQGFEPPTFTGWFTAWDPTKWSSGKSYEELKKEFGDTASPVNVTVAVCKVLFISQTLFRLKLATKFYKYLSDTDFTTVFGMTKDEFVSLPQWKQLKMKKEKGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9Z1</accession>
    <name>A0A3P9D9Z1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zgc:195001</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9Z1"/>
    <dbReference type="Ensembl" id="ENSMZET00005032181.1">
        <property type="protein sequence ID" value="ENSMZEP00005031174.1"/>
        <property type="gene ID" value="ENSMZEG00005023248.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151196"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF14">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="33"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="230" mass="25937" checksum="959F12CFCF7B82E4" modified="2019-02-13" version="1">MPNCAVRNTRIMPVPRKAGRKNSSATEVTLPPYEPNIPEPTTRADFMKYWIPLSFDDRTAEKLLWISEGGSKVARTSSDAVCPYPQRPERYDHSPQVLCKEGLLGHRGYWEVEYDGWVVIGVVSESSPRKMQDGPCGIGENKTSWGAGWSGSCCQIWHNAENVDIQMPLSSTMGVYVDQPAGIIKFLLVEGEAEKEVRLIHKFKENLQEKVFPGFWVGTNSFCLIRKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAD5</accession>
    <name>A0A3P9DAD5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tocopherol (alpha) transfer protein-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004560337.1">
        <property type="nucleotide sequence ID" value="XM_004560280.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9DAD5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031518"/>
    <dbReference type="Ensembl" id="ENSMZET00005032545.1">
        <property type="protein sequence ID" value="ENSMZEP00005031518.1"/>
        <property type="gene ID" value="ENSMZEG00005023506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473266"/>
    <dbReference type="KEGG" id="mze:101473266"/>
    <dbReference type="CTD" id="79183"/>
    <dbReference type="GeneTree" id="ENSGT00940000155407"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
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    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
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        <property type="entry name" value="CRAL/TRIO_N_dom"/>
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        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
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        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
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        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
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        <property type="entry name" value="CRAL_TRIO"/>
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        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
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        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
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        <property type="entry name" value="CRAL_TRIO"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="285"/>
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        <source>
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        </source>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031518.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="345" mass="39334" checksum="71A85CFB63431D98" modified="2019-02-13" version="1">MADQHESIDLGGPTVDSSAAAVHSWFPSPPPPIYSCTLTPELVAKAREELQEKPEWRLRDVQALRDMILKEQPNLRTRLDDAFLLRFLRARKFDYDRALQLLLNYHAGRKAWPEVFQDLKPSTVKHVLDLGFLTVLPRPDPNGRYILCLRPGKWKPNDYPFVDNVRAIYLTLEKLIQPEETQVNGIVILADYTGVGMSQASNPGPFLAKKVVSILQDGFPIRIKAVNIINEPRIFKGIFAIIKPFLKEKMAERYILHGSDLRSLHRNIPRSVLPEEYGGTAGQLDMSAWSRLLLDCEEEFVVEFCQPDPLEGVVLPESMLFEGEQASGHDDDTFRGLRSQLYYCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAU7</accession>
    <name>A0A3P9DAU7_9CICH</name>
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            <fullName evidence="19">CD166 antigen homolog</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004575142.1">
        <property type="nucleotide sequence ID" value="XM_004575085.3"/>
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        <property type="nucleotide sequence ID" value="XM_024804099.1"/>
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        <property type="nucleotide sequence ID" value="XM_024804100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAU7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031484"/>
    <dbReference type="Ensembl" id="ENSMZET00005032510.1">
        <property type="protein sequence ID" value="ENSMZEP00005031484.1"/>
        <property type="gene ID" value="ENSMZEG00005023477.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485067"/>
    <dbReference type="KEGG" id="mze:101485067"/>
    <dbReference type="CTD" id="30194"/>
    <dbReference type="GeneTree" id="ENSGT00940000156881"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051116">
        <property type="entry name" value="Surface_Rcpt/Adhesion_Mol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11973:SF2">
        <property type="entry name" value="CD166 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11973">
        <property type="entry name" value="CELL SURFACE GLYCOPROTEIN MUC18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
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    <keyword evidence="10" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="chain" id="PRO_5018257152" evidence="17">
        <location>
            <begin position="23"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="506"/>
            <end position="528"/>
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    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="131"/>
            <end position="231"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="238"/>
            <end position="322"/>
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    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="332"/>
            <end position="397"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="404"/>
            <end position="485"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="558" mass="61555" checksum="91FF24783FC26F65" modified="2019-02-13" version="1">MDTVALLLLFVVNAGTLVQVKGTANLTTLYGETIVMPCNGGAPPPKDLMFIKWKYEKDDGTPGDLLIKQAHSDQATVQATDGYAQRVSINRHFSLLITQASLKDQRTFTCMVVSDANLMEYPVSVVVYKKPSPVRIMDKSELLQKDKLTAVGTCVVAEANPPATIKWRKNGQLLKDDQKSVVITNHLKLDPDTGLSTMLSTLQYAATKEDADAIFACEATHTLINQETELEPFPIHYPSEQVTLQIMSQPSIIEGDNVTLKCTADGNPPPRSFFFHIKGTKVLVENSDNYTVTAINRKDTGEYKCSLVDNEKVEASQNIVVSYLDLSLSPTGEVVKNVGETLSVKIEKSTSGDAKELWKKNGKMVKRPEFSNLTFADAGDYICEVSLTGLTRRQSFQLVIEGKPRITNLTKYRAADGKDTVLTCEAEGVPKPQFQWSVNNPIKEESSYINGKVIHKITIVPKENLNITCNVSNRLGQHAETISVSSVFKEENKGRGSREDRDQAKLIGGVVAGLVLVGITVGLICWLCSKKSRQGTWKTKEEINRSHENEKLTPIDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DBN3</accession>
    <name>A0A3P9DBN3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein CYR61</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539319.1">
        <property type="nucleotide sequence ID" value="XM_004539262.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DBN3"/>
    <dbReference type="Ensembl" id="ENSMZET00005033148.1">
        <property type="protein sequence ID" value="ENSMZEP00005032110.1"/>
        <property type="gene ID" value="ENSMZEG00005023934.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479175"/>
    <dbReference type="KEGG" id="mze:101479175"/>
    <dbReference type="GeneTree" id="ENSGT00940000165172"/>
    <dbReference type="OrthoDB" id="365605at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000015">
        <property type="entry name" value="CYR61 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050941">
        <property type="entry name" value="CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012395">
        <property type="entry name" value="IGFBP_CNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043973">
        <property type="entry name" value="TSP1_CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348">
        <property type="entry name" value="CONNECTIVE TISSUE GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348:SF20">
        <property type="entry name" value="PROTEIN CYR61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19035">
        <property type="entry name" value="TSP1_CCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036495">
        <property type="entry name" value="IGFBP_rP_CNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00121">
        <property type="entry name" value="IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01185">
        <property type="entry name" value="CTCK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017936754" evidence="7">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="94"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="8">
        <location>
            <begin position="285"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="381" mass="42236" checksum="6A924BF6FD10DE2A" modified="2019-02-13" version="1">MTFLIYLTLLTTVVITQVTARCPAVCECPAEPPVCPPGVSAVSDRCGCCKVCAAQLNQDCSPARPCDHHKGLECNYGNDVTMAWGICRAKSEGRTCEYNGRIYQNGESFRAGCKHQCTCIDGAVGCAPLCSNKLPPASPSCPYPRLVRIPGQCCFTVDCNKGTWRLPPKHQVHPPQQHPHRPRLHPVPRHPENDLVLANQLTDVKPSSWHSERGYKHLPVWSPLKENKCAVQTTDWSPCSRSCGMGVSSRLTNKNPQCKMERQTRICTIRPCHSLAVPAKKGKSCSPTEKVAEPIHLSYGECVSIRLYRPNYCGVCTDGRCCSPRRTRTVPVTFACPDGERFQRLSMLIQSCKCSSDCGHLNEVALPPQHWMYGDTHKFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCB9</accession>
    <name>A0A3P9DCB9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Large subunit of the RFC complex, an heteropentameric complex consisting of RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA and the interaction involves RFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564356.2">
        <property type="nucleotide sequence ID" value="XM_004564299.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCB9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031791"/>
    <dbReference type="Ensembl" id="ENSMZET00005032824.1">
        <property type="protein sequence ID" value="ENSMZEP00005031791.1"/>
        <property type="gene ID" value="ENSMZEG00005023710.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101476928"/>
    <dbReference type="CTD" id="5981"/>
    <dbReference type="GeneTree" id="ENSGT00730000111066"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061860">
        <property type="term" value="F:DNA clamp unloader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="406"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="242"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="495"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1093"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1104"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1136"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1151"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1161" mass="126706" checksum="8462359E5EF6ED6C" modified="2019-02-13" version="1">MDIRRFFAPTSAKPAVQKPAPNGNDKQEKKKKNSSSTDEEVKKKKKEANKVKSKKTEEQRKDGEKKRKKHAVIASDSDEEEPVRKSKSPKEKAKTNKKDPVQYVSETDSDSDNFQSLKKTSKSKQNGAAKTTKADAKQSGKSPVKPSSTQGKTTPKSPPVPSTPKSAPPPQSKQTPTSVLDYFGSASVQRSDKKLVASTKRKAPTLTDDLISDEEIARQLQMEEDMELEKQVHEDEEFARTLAMLDEEPKAKKARKGSDEKQVLTTSPKKKATDAAAPGSSSKTSVSEDVVSPSPKKTTAPVKASSKLAMMKKKDDDKNEGVKSKTPTKMKISPKKEPHASSISEKTFTPKTGTTPTALKTSPKKPESTSTSPDDQEKKKANSSAYRNFLNRDGPRALGSKEIPKGAENCLEGCVFVLTGVLESMEREDAKSLIERYGGKVTGNVSKKTTYLIQGRDSGASKLEKAESFGTQILDEDGLLELIGTKPGKKSKYEIAAEAESKTTKTKTPPSQASKSTPKAQKISPSKGNSRSPHTPSPSKTGQAQGRGTKTRDGGTPPGRGSGQTARRELGLSSATSSSSSVPEQSSPSPTEEGGSLLWVDKYRPRSLKAVIGQQGDQSCANKLLRWLQNWYKNHGSGKPAAARFGKFGGKDDGSGFKAALLSGPPGVGKTTTAALVCEELGFSYVEMNASCTRSKNSLKEVVAESLNNTSIENFYKGTSQTVSSKHVLIMDEVDGMAGNEDRGGIQEMIGLIKNSKIPIICMCNDRNHQKIRSLANYCFDLRFQRPRVEQIKGAMMSIAFKEGIRIPPPALNEIILASNQDVRQVIHNLSMWSAKDKVMTYDQCKSDAASARKDMKLGPFDVCRKVFASGEETARMSLIDKSDLFFHDYSLAPLFVQENYLHVRPAAAGGNLKSHLVLLSKTADSICDGDLVDRRIRSGQNWSLLPTQAIYASVLPGELMRGYMNQFPIFPSWLGKNSSTNKHSRIVQELSSHMGLKTLSSKQAVNLDYLHYLRQAILNPLQKHGAEGAAEAVQLLDDYQLIKEDVDSIMEISVWGGQPDPYSKLDSKVKAAFTRTYNKEVHLTPYSLQVVKKGRRGGGGDFEGGEEISQEDPESEDEGERLKADAMIKHKKAKPTKESNKEKKEDSGKGKGKGKGKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DD19</accession>
    <name>A0A3P9DD19_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Histone acetyltransferase</fullName>
            <ecNumber evidence="25">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="28 29">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 25">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="25"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DD19"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032585"/>
    <dbReference type="Ensembl" id="ENSMZET00005033643.1">
        <property type="protein sequence ID" value="ENSMZEP00005032585.1"/>
        <property type="gene ID" value="ENSMZEG00005024277.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157744"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036409">
        <property type="term" value="C:histone H3-K14 acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902035">
        <property type="term" value="P:positive regulation of hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0045935">
        <property type="term" value="P:positive regulation of nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone acetyltransferase"/>
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        <property type="entry name" value="Histone acetyltransferase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="Zf-MYST"/>
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        <property type="entry name" value="Znf_C2H2C"/>
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        <property type="entry name" value="Znf_C2H2C_sf"/>
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        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
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    </dbReference>
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        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
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        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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    <keyword evidence="21" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="22" id="KW-0137">Centromere</keyword>
    <keyword evidence="15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20 25" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="27">
        <location>
            <begin position="345"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="45"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="23">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="ARBA" id="ARBA00022763"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01143"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="623" mass="71145" checksum="D1594CF7C5D157CF" modified="2019-02-13" version="1">MPRRKRTAGSSSDGTEDSDFSADVEHAEAAEIVHRRSSTRLTRASLRLSRSSQDNCSSPVTVGSDEALDSAVESAPTAVAASVFSSGRRVTRSQQGAANTTAKKYPLRQSRSSGSDTEAHDIKQGADRDETPPRTPTGNAPSSESDIEVSSPSNDLVSSSNDIVVSQEEDERLAKELSLKEAAAHDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGRHERHFSISGCPLYHNLSADECKGKASTRDKQAEERTLSHRQDENRHSTRNQAPTERQLRYKEKVTELRRKRNTGLNKEQKEKYMEHRQSHGTSREPLLENITSDYDLELFRKAQEKLRLAGQVSEGSNMIKTIVFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGNISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLVGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLNNFQGKEISIKEISQETAVNPVDIVSTLQSLQMLKYWKGKHLVLKRQDLIDDWKAKETKRGNSKTIDPTALKWTPPKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDA2</accession>
    <name>A0A3P9DDA2_9CICH</name>
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        <submittedName>
            <fullName evidence="11">Protein phosphatase 1, regulatory subunit 13 like</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004560520.1">
        <property type="nucleotide sequence ID" value="XM_004560463.2"/>
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    <dbReference type="RefSeq" id="XP_004560521.1">
        <property type="nucleotide sequence ID" value="XM_004560464.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004560522.1">
        <property type="nucleotide sequence ID" value="XM_004560465.4"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005032488"/>
    <dbReference type="Ensembl" id="ENSMZET00005033541.1">
        <property type="protein sequence ID" value="ENSMZEP00005032488.1"/>
        <property type="gene ID" value="ENSMZEG00005024199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473148"/>
    <dbReference type="KEGG" id="mze:101473148"/>
    <dbReference type="CTD" id="10848"/>
    <dbReference type="GeneTree" id="ENSGT00940000160551"/>
    <dbReference type="OrthoDB" id="10038642at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Apoptosis-stimulating of p53 protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028320">
        <property type="entry name" value="iASPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24164">
        <property type="entry name" value="RELA-ASSOCIATED INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24164:SF4">
        <property type="entry name" value="RELA-ASSOCIATED INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
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        <location>
            <begin position="624"/>
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        </location>
    </feature>
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            <begin position="36"/>
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        </location>
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            <begin position="36"/>
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            <begin position="55"/>
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        </location>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="790" mass="86777" checksum="71DB1D6A07A5FEAB" modified="2019-02-13" version="1">MSSQTSFGSSMLFQTMNDDLSASLATADELSKEFNSLLQEASTSNNNTESKSQATSSISREQPQSSWSSSTSTTKQASGGSSNGSPSSSAYSTSSASFRPIDSVSSNNNNTRSSPVFPPSPLSSPKLQRSAHGSDIVHHSYSHSAQNTKYNSLPHYDKSPRSSVSSTDRSPAPNSKAVTLEPSASAHSNLLRPYDSSQMRPRSPRFDRSPSPLSANYPMSSTLPRNFSSSRQQDEAVQWQKSPGKWNETDLDMSYERKPHHTYDKTEWLRSTMPNPNWKESNLDGPSPAPSPIKDRLSNTLQFSSGSLPRNARIAVPPSQSHSPYQSQPISRISIPPNSTQSRQHKPIPLSVIMRLQNPYWGAMIAPQPRVVGGQSDMSPYQPAVPVPKEFFQPPAVQPQLKPPELWQPALYSDVLNPADIDAELERLVSAQQNPVNLENPAISEGSVETEGTNQQPPRPLSPTTLQPVVAPDAQSHVTPVIEEVLRIRAEIPRALKRRGSVNLSKPLKKPSHYQPNQYKHLINKLFRKEYHNKADKGSESSSSSDGEDSALPPPPPPKTPTLIKNDKNYRSILRLPNRKRKNSGRRARLSPLVLVLDGALAGDLDTVQKAVQEMSDPSQPNEEGITALHNAVCFRHHDIVDFLVRIGVNVSAPDSHGWTPLHCAASCNDRPLCEFLVRSGAAVMAVTESDRATASQKCDPYAPGYEECETFLRAAEEAMGVDNSGVLYALWSYPAQAADELSFKDGDMVTILQKPEGSDWWWASLCGREGFVPNNYFGLFPKVRPKSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDV0</accession>
    <name>A0A3P9DDV0_9CICH</name>
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        <lineage>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DDV6</accession>
    <name>A0A3P9DDV6_9CICH</name>
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        <submittedName>
            <fullName evidence="9">F-box protein 40</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
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                <person name="Alcazar R."/>
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                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004560560.1">
        <property type="nucleotide sequence ID" value="XM_004560503.3"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005032331"/>
    <dbReference type="Ensembl" id="ENSMZET00005033375.1">
        <property type="protein sequence ID" value="ENSMZEP00005032331.1"/>
        <property type="gene ID" value="ENSMZEG00005024085.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483222"/>
    <dbReference type="KEGG" id="mze:101483222"/>
    <dbReference type="GeneTree" id="ENSGT00950000183204"/>
    <dbReference type="OrthoDB" id="5918172at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRAF-like zinc-finger, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031890">
        <property type="entry name" value="Fbxo30/Fbxo40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043013">
        <property type="entry name" value="Znf_TRAF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15933">
        <property type="entry name" value="PROTEIN CBG16327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15966">
        <property type="entry name" value="F-box_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="557"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="685" mass="77171" checksum="6B9C43891BE428A8" modified="2019-02-13" version="1">MVKSMKMPVGYHKHCDKCYNVHCQVPAQTSVSCIVVKCHKNCGASLHMCKQEEHQLLCPNEIVPCLNVYYGCPLTMLRHRLAKHLEVCPASLVCCSQEWNRWPISESDLTFYRNVSENPVVNTEENLDVAMAHRDQEQLFQSIKMKNIFPELILEDSAVQNIAAGINSPADNACCSVDSGEYTENGSAKLDEELSQEERDTLAKCTDVTSIQNYSSWEKIFNKEKEGCKQTIKNLNKGEKGKEKEDQESSKSQKELHQGGECPVTARTMDGATGLAPWQDGVLERLGKEVNIAEYNMYLVHNGVMLINFGQLAACTPREKDFVYGSLEPIEVKSVRTFNVPTSYRAKRNHLKDPSRKAQTTHQSVDTSDLGISIEDLPKCEEVSTTLLCSLEKELKGHSISESVSTDGLYTDIGTQTYIFSSAPFKQDASLADVIAGKPCRLYLYIEAESVTRRHNKTSSAFSYMCGHYFRRDEYCFHFKNVHSDIQASLNGWFQQRCPLAYLGCTFTQMRFHPTGQEAIVKFSKDGSTLVLQPKANSSLCAGGKTFSPKRNDAQNLDPLSSLPLEIIQHIAGYLDSFTLSQLSQVSHLLREVCATLLQERGMVSLKWEKKKHSSEGSSWICQKKVWKFSSQFSSVDRWSFSDTPSMSNHLGTCSFYQREDRTEPVALPCLGEVRDKHGKLKHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGL7</accession>
    <name>A0A3P9DGL7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P2Y purinoceptor 14-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGL7"/>
    <dbReference type="Ensembl" id="ENSMZET00005034678.1">
        <property type="protein sequence ID" value="ENSMZEP00005033529.1"/>
        <property type="gene ID" value="ENSMZEG00005025051.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01110000267167"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045028">
        <property type="term" value="F:G protein-coupled purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24233:SF11">
        <property type="entry name" value="P2Y PURINOCEPTOR 14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24233">
        <property type="entry name" value="P2Y PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="30"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="316" mass="35880" checksum="0C6DE3AEDE9D984A" modified="2019-02-13" version="1">MADSKNMTSSFNQTCDPVVPSLNTFFVLVYSLVFLFYIGQAQQQASSSLMVYLKNLTAADFLLCLSLPLRIAHYGSKSLIIRRLYCSFGASALFLNMYASILFMCYIAANRYLKIVHPSGTHVLQSLRTAHIISMVTWVCLLAPSVTFAIAFFITQKPLTFTPSHCGALFSVSISLFFKILHTLWTIIFLLVSISLVFFYYSISRRVLQAQQRQLASSNAEKLVKSRRNMLVLVSIFCVCFVPYNLVRLPATFLWTSCSAGPVLFYLEEVAIMLSVFNICLDPVVYFFLCKTFRAQVRRVSRRVDDPNEQANRPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHG2</accession>
    <name>A0A3P9DHG2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid receptor RNA activator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Steroid receptor RNA activator protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SRA1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004556986.1">
        <property type="nucleotide sequence ID" value="XM_004556929.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024659584.1">
        <property type="nucleotide sequence ID" value="XM_024803816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHG2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033461"/>
    <dbReference type="Ensembl" id="ENSMZET00005034592.1">
        <property type="protein sequence ID" value="ENSMZEP00005033461.1"/>
        <property type="gene ID" value="ENSMZEG00005024979.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005034794.1">
        <property type="protein sequence ID" value="ENSMZEP00005033622.1"/>
        <property type="gene ID" value="ENSMZEG00005025134.1"/>
    </dbReference>
    <dbReference type="GeneID" id="112435365"/>
    <dbReference type="KEGG" id="mze:101487385"/>
    <dbReference type="KEGG" id="mze:112435365"/>
    <dbReference type="GeneTree" id="ENSGT00390000001803"/>
    <dbReference type="OrthoDB" id="5982138at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000006">
        <property type="entry name" value="steroid receptor RNA activator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
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    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3P9DI18_9CICH</name>
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        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4 gamma, 1a</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
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        </source>
    </evidence>
    <sequence length="1661" mass="184505" checksum="A89B3F7D14EBD881" modified="2019-02-13" version="1">MNKPPQPIAGPTSVPNPAPSPGLTQAAYGPGQPTSLVFATPPPPQMNSAPQPRQSYYQNRPTMATSAPRVPGNSGPRAVAPAHVYPPGSQMMMISQPFAGSPQGYFIPSGQYRAPYMPPTQQYPVTSGTANFYTGTSPAEYPPYAGAYYPTPPQYPPSVQPSTVMLSTQQQLQVPPPQQAPAQSQGLMKRERRPVITIRDPNQGGRDITHEILSGVMSSTTPTPQAPDASSAQVNGEIAQPVIAQTRRDDNTERPTSAETPPSLAAANAEPVLESKQEVDSQIVLPTELAAQSVAPVATTEVPSTLIKDQQSPPSLPPGATLTTTPAEAVNKVGTTVSDTVDAPHATSQSSEAPEAPVKIEELPAAPAQAEKGPEKEEAKTEEVKKVEKEEQVATTKLEPAAEAAAAGSSNLEEERKNKEEMATKTATEVSQPPPPAREPAGPQTQNAVLRSTPEPESTQVEAAEPVLPNGLPQETEELPKDNAISDTTPHKQPDASQSQESTPMAKTATAAQEVKEEAEEREEEEECKKKSEDTPPASVSCPEESTMQAATHVQRKKKNMKEFNKKEAIGNLLDAFTEEQGAKPASEPMPTQANPPAPAPAELPVEVADETWEQKEDKQNAEPDKSKATPEPTEQKYQYKQEEWKPINPEDKKRYDREFLLGCQFISASMHKPEGLPIISDVVLDKVNKTPLRPADPSRLMNTGPDFTPSYLGNLGSRSVGGPRGPPSGPRRSQTKKIITSMSLNDDVQLSKAEKAWKPSVKKVTRGRVDEPEEEDPEQAKTRELFKRLRSILNKLTPQKFQELMKQVTELTIDTEERLKGAIDLIFEKAISEPNFSVAYANMCRCLMGLKVPTSDKPGVFVNFRKLLLNRCQKEFEKDQDDDEIFEKKQKELEAAKDGEERERFRVELEEARDKARRRSLGNIKFIGELFKLKMLTEPIMHDCVVKLLKNHDEESLECLCRLLSTIGKDLDFEKAKPRMDQYFNQMDKIIKERKTSSRIRFMLQDVLDLRRNNWVPRRGDQGPKTIDQIHKEAEMEEHREQMKVQQQLMTKKESRDRFTGNMGSRGPHTPGGGRTSQPQDEGWNTVPISKNRPIDTTRLSKITKPGAMDFNNQLLAPGGKGMWGSWGKGSSGGTGAKPASGDQDSGRPGTSTLNRFSALQSGSLMSATDSDRRVPQRSSSSRERGSNRDRSDRNRDRFDRFDRSEGREANQVTKRSFSRESQERGGRGGDGRSSTESVRRVASMTDSRDRGSRDRGSRDRGSRDRGSRDKGSDFVPVKRESAPTPPPSLPKPALTEEEVEKKSHAIIEEYLHINDVKEALQCVVELNSTSLLYVFVRNGLESTLERSTIAREHMGLLLHQLIKAGTLPTQQYYKGLLEILEVAEDMAIDIPHIWLYLAELITPMLHEGGIPMGQLFREISKPLVPLGKASVLLVQILKLLCKEKTPNKVGALWTEAGLNWNDFLPKDEDVNKFVTDQKVEFTVGEEMEPKEASKKKVLSGEEISKQLDRLLQDKANNQRIRDWIEANLDEQQTASNQFVRALMTSVCQSAIICDNPYKVDAQQIGQRASLLQRYLYDEQKELQALYALQALMVHMEQPAHLLRMFFDALYDEDVIKEEAFYEWETSKDPAEQTGKGVALKSVTGFFTWLREAEEESDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIX5</accession>
    <name>A0A3P9DIX5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="20">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="20"/>
    <dbReference type="RefSeq" id="XP_004542706.1">
        <property type="nucleotide sequence ID" value="XM_004542649.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIX5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034101"/>
    <dbReference type="Ensembl" id="ENSMZET00005035299.1">
        <property type="protein sequence ID" value="ENSMZEP00005034101.1"/>
        <property type="gene ID" value="ENSMZEG00005025485.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475303"/>
    <dbReference type="KEGG" id="mze:101475303"/>
    <dbReference type="CTD" id="1263"/>
    <dbReference type="GeneTree" id="ENSGT00940000159121"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090166">
        <property type="term" value="P:Golgi disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044819">
        <property type="term" value="P:mitotic G1/S transition checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000189">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="65"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="23">
        <location>
            <begin position="483"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="23">
        <location>
            <begin position="581"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="667" mass="75465" checksum="4DDF448317B297B4" modified="2019-02-13" version="1">MSTGCFTAAQRISCHTMNADLFKPAAERGGPQQTSAPAKNSRNKHDQPKPELAQVVTDLKTGRSYIKGKLLGKGGFARCYEMTDLSNNKMYAVKVIPQSRVSKPHQRDKITNEIELHRTLSHKHVVKFSHYFEDQENIYIFLELCSRKSLAHIWKARHTLTEPEVRYYLRQIISGLKYLHSRGILHRDLKLGNFFINENMELRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTESDVWSLGCVMYTLMCGNPPFETLDLKETYKCIKEVRYNLPSTLSPAAQKLISGILQKNPSDRLTLDQILNHEFFKGFTPDKLPPSSCTMVPELHPPSPAKKFFTKMAKSLFGKKKAKVEKIPCEDKEDKDISKLVSGIVKCSINRQISYKTVGNNEVTSPTGQLVSSVPLEQTPAEEESRKSISRSFKGTMASSTEPCEDVLTPAAVADSALKVLTNCLATMPAANRNPPCLSSPQSFLWVTKWVDYSNKYGFGYQLSNQNVGVLFNEGTHLSLCDQRKTVHYCLTNNKHFSFPSNSLPEQLRNQKQIVELMANYMEENLMEGGDLHCQEHVSAPPPLLLQWVKTDHALVMLFNNDTLQVNFYTDHTKIILCKSSDDAYLLTYISRERASCTYLLSMLNEMGCTSELRHRLRYVVQLLQHHTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJP6</accession>
    <name>A0A3P9DJP6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 27">Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN</fullName>
            <ecNumber evidence="6 27">3.1.3.16</ecNumber>
            <ecNumber evidence="5 27">3.1.3.48</ecNumber>
            <ecNumber evidence="4 27">3.1.3.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Phosphatase and tensin homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="33 34">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="27">Dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also functions as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring of PtdIns(3,4,5)P3/phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4)P2/phosphatidylinositol 3,4-diphosphate and PtdIns3P/phosphatidylinositol 3-phosphate with a preference for PtdIns(3,4,5)P3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83420"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:43561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83416"/>
            <dbReference type="ChEBI" id="CHEBI:83419"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:43553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57627"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:77144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77155"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57895"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:77156"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:10685"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:25018"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Nucleus</location>
            <location evidence="27">PML body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 27">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6 27"/>
    <dbReference type="EC" id="3.1.3.48" evidence="5 27"/>
    <dbReference type="EC" id="3.1.3.67" evidence="4 27"/>
    <dbReference type="RefSeq" id="XP_004565290.2">
        <property type="nucleotide sequence ID" value="XM_004565233.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_024657139.1">
        <property type="nucleotide sequence ID" value="XM_024801371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJP6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034980"/>
    <dbReference type="Ensembl" id="ENSMZET00005036226.1">
        <property type="protein sequence ID" value="ENSMZEP00005034980.1"/>
        <property type="gene ID" value="ENSMZEG00005026172.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480618"/>
    <dbReference type="CTD" id="368415"/>
    <dbReference type="GeneTree" id="ENSGT00940000163053"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030351">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051717">
        <property type="term" value="F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051800">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010648">
        <property type="term" value="P:negative regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051129">
        <property type="term" value="P:negative regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023057">
        <property type="term" value="P:negative regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000003">
        <property type="entry name" value="Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000029">
        <property type="entry name" value="Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017361">
        <property type="entry name" value="Bifunc_PIno_P3_Pase/Pase_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038025">
        <property type="entry name" value="PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 27" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 27" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 27" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15 27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12 27" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="31">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="30">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="32">
        <location>
            <begin position="192"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="364"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="29">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="28">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00043760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRNR" id="PIRNR038025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR038025-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="411" mass="47800" checksum="B18514AC8D7B3354" modified="2019-02-13" version="1">MAALIRIRGIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDSSKFNCQVAQYPFEDHNPPQLELIKPFCEDLDKWLSEDEQHVAAIHCKAGKGRTGVMICAYLLHRGKFQEAQEALDFYGEVRTHDKKGVTIPSQRRYVVYYNFLLKNQLQYKPVALLFHKMLFETIPMFTGGTCNPQFVVYQLKVKIHTSNPGHTRREDKLMLFEFPQPLPVCGDIKVEFFHKQNKVLKKEKMFHFWINTFFIPGPEEVPERMENGSAGTPRELFDRTPQTPMTPGSETNDRDYLVLTLTKNDLDKANKDKANRNFSPNFKVKLFFTKTVEEGANCDASSTSSMTPDASDNEPDHYRYSDTTDSDPENEGFEDEDHNQITKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJQ4</accession>
    <name>A0A3P9DJQ4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fucolectin tachylectin-4 pentraxin-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJQ4"/>
    <dbReference type="Ensembl" id="ENSMZET00005035596.1">
        <property type="protein sequence ID" value="ENSMZEP00005034386.1"/>
        <property type="gene ID" value="ENSMZEG00005025628.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01060000248575"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF8">
        <property type="entry name" value="SI:CH211-215K15.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="10">
        <location>
            <begin position="128"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="10">
        <location>
            <begin position="265"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Fucolectin tachylectin-4 pentraxin-1" evidence="10">
        <location>
            <begin position="410"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="516" mass="55955" checksum="3D8443FE7B526051" modified="2019-02-13" version="1">AKPENAIDGNRASNYNQGSCACTNNNLNPWWRLDLLKTYKINTVTITNRQDCCPERINGAEIRIGNSLNDNGNANPRCAVISSIAAGASQTFACNGMEGRYINIVIPGRTEYLTLCEVEVDGTLSETNVARLGQVAQSSTYGNAKPENAIDGNRASNYNQGSCACTNNNLNPWWRLDLLKTYKINTVTITNRQDCCPERINGAEIRIGNSLNDNGNANPRCAVISSIAAGASQTFACNGMEGRYINIVIPGRTEYLTLCEVEVDETNVARLGQVSQSSTYGNAKPENAIDGNRASNYNQGSCACTNNNLNPWWRLDLLKPYKINTVTITNRQDCCPERINGAEIRIGNSLNDNGNANPRCAVISSIAAGASQTFACNGMEGRYINIIIPGRTEYLTLCEVEVDGTLSETNVARLGQVSQSSKLDLLKTYKINTVTITNRQDCCPERINGAEIRIGNSLNDNGNANPRCAVISSIAAGASQTFACNGMEGRYINIVIPGRTEYLTLCEVEVDVKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMK5</accession>
    <name>A0A3P9DMK5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized LOC112436673</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAMHD1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMK5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035657"/>
    <dbReference type="Ensembl" id="ENSMZET00005036919.1">
        <property type="protein sequence ID" value="ENSMZEP00005035657.1"/>
        <property type="gene ID" value="ENSMZEG00005026639.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005036921.1">
        <property type="protein sequence ID" value="ENSMZEP00005035659.1"/>
        <property type="gene ID" value="ENSMZEG00005026639.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005036924.1">
        <property type="protein sequence ID" value="ENSMZEP00005035662.1"/>
        <property type="gene ID" value="ENSMZEG00005026639.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005036927.1">
        <property type="protein sequence ID" value="ENSMZEP00005035665.1"/>
        <property type="gene ID" value="ENSMZEG00005026639.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013867"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="4">
        <location>
            <begin position="91"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="543"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="769" mass="89819" checksum="2614CBB9613949B7" modified="2019-02-13" version="1">MAKMNKVNQKSCKTPPFEINQPDKDDDDTNPGTCKIAVQENSKDLRKVFNDPIHGHIELHPLLVKIIDTPQFQRLRNIKQLGGIYFVYPGASHNRFEHSIGVAHLAGELAKALKVKQLEQIKPLEELKELKELKKLKPLELEQLKKLQNLTPQDLKELQELMPDNLEKLKKLQNSKPEDFEKLKAEELEDLKKLVELENLGFTKLEKLKKLQNSKPEDLEKLNPEDLKMLQRFKPKDVEKFEKLERLDELKKSLISDQDVLCVQIAGLCHDLGHGPFSHFFDGMFMDAIKRDKKGKADKEVTDNEKWTHEKASIEMFKHLLDQNGLKEVMKKYGLKVDEDGTDLVFIEEMIKKPQDEKPQNDAAQDNEHQNNDASKKVLWPYKGREEKKSFLYEIVSNKNTGIDVDKFDYFARDCHHLGIPNSFDHQRFVMFARVCDVEEDRKKTKHICSRDKESANLYDIFQQRLSIHRRACQHKIKMAVEIMLKDALILVDDHPDFKIKSSKGEMLNISQANGDMEAYTKLTDHVFERILHYQEGRKEPSSEEERKKEQDLEQAREILKRVMERDLYRCVGQAKKKSGEEIKERLKNLVNDIQEDGKDRDEVNNVTLTYNMGNEKSITKEYSYDKENSKTPEDKKKEKKEALEKIKEDLEGKLSECSPDDKFEVIDVTLDYGMENDDPLIKAYFYRKDNPDKGEPIPKSDVFSVLPDWFSDEMLRVYWKNPKELTDEQIKTKEEEFKKVFNDWCKENGYKDLNKEVPSAGRATSGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ34</accession>
    <name>A0A3P9DQ34_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Si:dkey-251i10.2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FRRS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024655539.1">
        <property type="nucleotide sequence ID" value="XM_024799771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ34"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036865"/>
    <dbReference type="Ensembl" id="ENSMZET00005038154.1">
        <property type="protein sequence ID" value="ENSMZEP00005036865.1"/>
        <property type="gene ID" value="ENSMZEG00005027472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485615"/>
    <dbReference type="KEGG" id="mze:101485615"/>
    <dbReference type="GeneTree" id="ENSGT00940000165599"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.4060:FF:000003">
        <property type="entry name" value="Ferric chelate reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF32">
        <property type="entry name" value="SI:DKEY-251I10.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018308052" evidence="2">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="3">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="196" mass="21096" checksum="5225F4F64330D863" modified="2019-02-13" version="1">MELLWPGLLILQMFCFINGYPNGAPSGACEDMLPRHSGVLPQPSPAPYTILTNARVFQPGKPITVTIVGPKYRGVLLEARIGGGLNAVGTWQRPPPDTKFLQCAHNPRGAVTHSNTNLKGNSTVYSWIPPNCEGPVYFMATVAQQRTVFWVNIRSMDLTRGKTGGLDLAVGASAGMAEGKPLLPLVICFLILNILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DR55</accession>
    <name>A0A3P9DR55_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nematocyst</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DR55"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036929"/>
    <dbReference type="Ensembl" id="ENSMZET00005038219.1">
        <property type="protein sequence ID" value="ENSMZEP00005036929.1"/>
        <property type="gene ID" value="ENSMZEG00005027523.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165500"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042151">
        <property type="term" value="C:nematocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051715">
        <property type="term" value="P:cytolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046931">
        <property type="term" value="P:pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050677">
        <property type="entry name" value="Actinoporin_PFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009104">
        <property type="entry name" value="Anemon_actinoporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40388:SF2">
        <property type="entry name" value="ACTINOPORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40388">
        <property type="entry name" value="BRYOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06369">
        <property type="entry name" value="Anemone_cytotox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0166">Nematocyst</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="4" id="KW-1053">Target membrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="147" mass="16089" checksum="71841B1BE0BFF1B4" modified="2019-02-13" version="1">NKYVRLLHLVSGLCQIPLPTKLGPSECGSALFSKTGGTARGSVGVFTYDLYDTAADRADKKIAVLFSVPFDYGLYSNWCATGVFDGETNSDSALYDKMYRTPERGFVRGKADGYDLTHTDINVTIKSSMTNFSVATLKVEVHNKVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DR69</accession>
    <name>A0A3P9DR69_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SHH signaling and ciliogenesis regulator sdccag8</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004551480.1">
        <property type="nucleotide sequence ID" value="XM_004551423.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DR69"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036737"/>
    <dbReference type="Ensembl" id="ENSMZET00005038024.1">
        <property type="protein sequence ID" value="ENSMZEP00005036737.1"/>
        <property type="gene ID" value="ENSMZEG00005027392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476892"/>
    <dbReference type="KEGG" id="mze:101476892"/>
    <dbReference type="CTD" id="10806"/>
    <dbReference type="GeneTree" id="ENSGT00940000164292"/>
    <dbReference type="OrthoDB" id="10252347at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043009">
        <property type="term" value="P:chordate embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035148">
        <property type="term" value="P:tube formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031887">
        <property type="entry name" value="SDCCAG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34343">
        <property type="entry name" value="SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34343:SF1">
        <property type="entry name" value="SEROLOGICALLY DEFINED COLON CANCER ANTIGEN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15964">
        <property type="entry name" value="CCCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="597"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="706" mass="80753" checksum="E9038809105C8DCB" modified="2019-02-13" version="1">MKPTDSDEDEAEHPSSMQKELRQRANQSIQHLSSAPLQLDPDGDEVEEVRGGDEDHYTTMAEEDKAAWNQKSQSEAVNQLKSLLLKQGREIPTPVSPSKKQSPSKEGMSSLPAFQDLVPVFHKSEYIQHLEAEVKFCKEELQGMKQRIRVVVVENEKLRSELKAEAVDESLKDYTIRNSTMNEVIDNSHVASIRDHSVLQKEEHNTWKNELEKLKVIYQAQMESLEAQVISLRKDLSVSQKECEEVKLRLRHREKQAADALKADGAPRVAGLCLKCAQHEAVLAGTHTNLHVQAIDRLTKERDELLVALRAVRASQQETQQREWSACLQVKQAVEMAEEANLQKARVEVQCEQLSRELARQREQLDRDAHGLQQRLAEAREEGRAEARKQKEELTNIVSGLSQRVAELEGQLDRALRDKSSLTSQLEDTLRTLTSQEQENTKVCVDLRYQLSQAALKKQEAERELRELNAKTSRRMEKAAQEVERLSSELVGCRQHLEAVQKDGSQWQAEALSLAEQLANAQRQLHLTRQDREGADRAHEEEMASVTLSARERERELTVMLQQAEAEHLQRVGELDGLLSSQNSLIGRLKEECCNLGTKLEELAEKSRSELEQLALEKQHLEETVKNLRARCSDMEEQCVQHGRMHQRMKDRLQQLDRHCQSSAQQVCELLAKQNQLMQERNTLSEEMQSLRIELPNTRRTETLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS39</accession>
    <name>A0A3P9DS39_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DEP domain containing 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004562106.2">
        <property type="nucleotide sequence ID" value="XM_004562049.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS39"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037585"/>
    <dbReference type="Ensembl" id="ENSMZET00005038894.1">
        <property type="protein sequence ID" value="ENSMZEP00005037585.1"/>
        <property type="gene ID" value="ENSMZEG00005028034.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101478710"/>
    <dbReference type="CTD" id="76131"/>
    <dbReference type="GeneTree" id="ENSGT00950000182976"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000182">
        <property type="entry name" value="DEP domain-containing protein 1B isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF12">
        <property type="entry name" value="DEP DOMAIN-CONTAINING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="867" mass="96952" checksum="04429B9592036DB0" modified="2019-02-13" version="1">MTSHVISPGPYRATKLWNEVTRLFRAGMPLRKHRQNFRHYASCFTASAAVDWLHQLLCNNSNFGPDVTRQQTVQLLKKFLKNHVIEDVKGRWGTEDLEDNNVLYRFPSTSPLKPIPCAAPASESRSIKKRPSFKDKEGFFRFRSTRRQEKETQENVDPALRIQQEGDNQPEEEQQKQRRELTVEDEQEIWRDITLTHLQRILDVPSLDEVLDHRYVNPQNIIHNMTKVNKHGVVTLDDKTNDLPDWVLSAMRSLANWPKYNGTQQSYPGFERDVFKTVSDYFYSLPQPLLTYELYELFINVLVFCGYVAAPSMHQHLKRKKSDLPAVPPPAKTSFRSTECLLLSLLRQGTCDETESPMREVIGGKLQSRLAALKGGGGADDGPLGGSCISLSTVVPTRPQTRSCSLETILDDSAPLTRQQLFQSSDSLASFAYSSRSQDDSSSITTPHTRSFGTSVSKPAPITSENAPGVTARNRLSVIPLAGLSASHRSRSLRPHSFSSCLDIVIETREEDVKELKWQGRAASCLSVNSPSSQCQASSASHPPSLSSCHPFSSSFRPFPSSFSSAATKAQGSNAATGPRPASSTSNLWTLPAPAAVRRCLSSLEVSHLSQPVSLLKAPVSVSAGNSQPPQNQNEHSVLQPQCERVAIEALQLCTLLLPPASRRKLQLLMRMASRISQNVDMPRLHPAIGTRTLMVHTFSGCVLGSAEECDLDELLATRLVSFLMDHQQSILSVPEYLLGAISDHIQYLRTSQVPIDSVSKTDKSDLVCPPLPVYTFCHQISGAEFEQQKLESSQKAMEELLEILVTDQNISEKDRRKKLKQFQKQYPDIYRQRFPSPDRESKTDNKPKIKPPLLNIKKTKAFSIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSZ4</accession>
    <name>A0A3P9DSZ4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Formin binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FNBP1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSZ4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037579"/>
    <dbReference type="Ensembl" id="ENSMZET00005038888.1">
        <property type="protein sequence ID" value="ENSMZEP00005037579.1"/>
        <property type="gene ID" value="ENSMZEG00005028031.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183047"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11628">
        <property type="entry name" value="HR1_CIP4_FNBP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000002">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000017">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057871">
        <property type="entry name" value="HR1_CIP4_FNBP1L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF14">
        <property type="entry name" value="FORMIN-BINDING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="18">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="19">
        <location>
            <begin position="346"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="496"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="278"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="419"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="563" mass="65505" checksum="4F7013BAB128D66B" modified="2019-02-13" version="1">MSWGTELWDQFENLDKHTQWGIDFLERYAKFVKERLEIEQNYAKQLRNLVKKYCPKRSKDEEPRFTSCLSFYSILNELNDYAGQREVVAEEMAHRVYGELMRYSQDLKAERKHHLQEGRKAQQHLDHCWKQMDNSKKKFERECKEAEKSQITYERLDNDINATKSEVEKAKAQFYMRTHAADESKNEYAAQLQSFNAEQWKHFHSAIPQIFKNLQNMDERRTVKLGETYRSFAEAERRVIPIISKCLEGMVSAAKAVDERRDSAIVVESFKSGFEPPADFPFEDFSQNLSRTGSDGTISNTPKGDRERDGAPGPRSDPKHPMSRTKNKLWLFGKKPKAPSLEDFSHLPPEQRRKRLQQRIDELNRELQKEMDQRDALNKMKDVYEKNPQMGDPNSLQPKISETICNMEKLRSEIHKNETWLSEVEGKQSSRGDRRHSADNHHHGPQGRESPEGSYTDDTSQEHQTPHHRPGPAQPRHPNPDPHEFDDEFDDDDPLPVIGHCKALYSFDGQNEGTLVMAEDEVLYIIEEDKGDGWTRARKQSGEEGYVPTSYVEITLEKNSKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTB6</accession>
    <name>A0A3P9DTB6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTB6"/>
    <dbReference type="Ensembl" id="ENSMZET00005039379.1">
        <property type="protein sequence ID" value="ENSMZEP00005037980.1"/>
        <property type="gene ID" value="ENSMZEG00005028398.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164979"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF77">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="100" mass="11076" checksum="2A6F7EAD901DE5FE" modified="2019-02-13" version="1">MSLEDELTCSICLSTFDCPVTIPCGHNFCQDCLLASWEDSYSCPQCRTVFDTKPELKKNTGLCAYLLLLEHICINTTMSGWSEVWSLLPPPFSAACWSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARR6</accession>
    <name>A0A3P9ARR6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Unc-119 lipid binding chaperone B</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004558587.1">
        <property type="nucleotide sequence ID" value="XM_004558530.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARR6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000097"/>
    <dbReference type="Ensembl" id="ENSMZET00005000138.1">
        <property type="protein sequence ID" value="ENSMZEP00005000097.1"/>
        <property type="gene ID" value="ENSMZEG00005000119.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473843"/>
    <dbReference type="KEGG" id="mze:101473843"/>
    <dbReference type="CTD" id="84747"/>
    <dbReference type="GeneTree" id="ENSGT00390000014595"/>
    <dbReference type="OrthoDB" id="10248777at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070121">
        <property type="term" value="P:Kupffer's vesicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.40:FF:000001">
        <property type="entry name" value="protein unc-119 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="entry name" value="GMP phosphodiesterase, delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051519">
        <property type="entry name" value="PDE6D_unc-119_myristoyl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951:SF3">
        <property type="entry name" value="PROTEIN UNC-119 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12951">
        <property type="entry name" value="RETINAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GMP phosphodiesterase delta subunit" evidence="7">
        <location>
            <begin position="85"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="247" mass="28259" checksum="6D61E1AB12456709" modified="2019-02-13" version="1">MNGSRNKPLQTVSKGPKDADTGTESNHRDRKSGGGMLKKLKSRRSQTEKWPVVTEDELRALGRDITPDHVLGLRAVTEDYLCRPEDNIYNIDFTRFKIRDLETGTVLFEIAKPPNSGPVESEEEGGDPDTSAGRFVRYQFTPAFLKLRTVGATVEFTVGDRPINSFRMIERHYFQGRLLKNFDFDFGFCIPNSCNTCEHIYEFPQLPDDLIRQMVAHPYETRSDSFYFVDNKLIMHNKADYAYNGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUT7</accession>
    <name>A0A3P9AUT7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylacetamide deacetylase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004543618.1">
        <property type="nucleotide sequence ID" value="XM_004543561.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUT7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001414"/>
    <dbReference type="Ensembl" id="ENSMZET00005001504.1">
        <property type="protein sequence ID" value="ENSMZEP00005001414.1"/>
        <property type="gene ID" value="ENSMZEG00005001181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467151"/>
    <dbReference type="KEGG" id="mze:101467151"/>
    <dbReference type="CTD" id="13"/>
    <dbReference type="GeneTree" id="ENSGT00940000155975"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF28">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="6">
        <location>
            <begin position="110"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="6">
        <location>
            <begin position="315"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="408" mass="46584" checksum="61032B9148E96C91" modified="2019-02-13" version="1">MRLGSIILFVAFCSFTAYYVYEPIPEEIEERWKLMLTNSFFRSLSHLADISELLGLKDYMGVMYFITLLEKIAPVSDEHVKVTEEKFDGVEVVLYQPKHRGSDTDLRRAIIYLHGGGWCLGSSRMSPYDLLARKVVTELDAVVLSVEYRLAPAHHFPIPYEDVYRVVKHFLQKGVLAQYYVHPGRIAVSGDSAGGNLAAAVTQQLQKEPTQQIQLKAQALIYPVLQALDLYTPSYQQNQYMPILPRTLMVRFWSEYFTSDKAFFRAMMANTHNNPESSSLLKFVNWSAFLPETYHRKYNYSAPAVTEGTVAMDGPSRSLADPRASPLLVPDAALRSLPKAYILTCEYDVLRDDGIMYATRLRAAGVEVTHEHYDTGFHGALMFTVWPTDFLIARRMTDNYIKWLKENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVD8</accession>
    <name>A0A3P9AVD8_9CICH</name>
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        <submittedName>
            <fullName evidence="3">Transmembrane protein 236</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVD8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001676"/>
    <dbReference type="Ensembl" id="ENSMZET00005001769.1">
        <property type="protein sequence ID" value="ENSMZEP00005001676.1"/>
        <property type="gene ID" value="ENSMZEG00005001371.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015525"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020394">
        <property type="entry name" value="Uncharacterised_FAM23-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31453">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31453:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="388" mass="42998" checksum="E869071FD8C13E65" modified="2019-02-13" version="1">MGSGRTVKFALCEVLQFAGLCVPLFIVMQRFAVIVAKVKTSAQPPGDGSTAYWLIVASSIAYVTSTALLVWVPLKYMVFMKKKFLIGRKKWRPVTLVYVILSTLPCFAFLIASSEVQINNNLKHDTFTELPVSLVLFSLICIDVVERIRHCRLTGQANDTERDADIPSTVLTHVEQVAPVTPITPAVPGPAVHRQGVPTPMQPGANQLNDRSHNGAGARPETNGTLPGIPGNNGRPYGMSGLSEPSGSTTPYHISPYAYTGPLRFLCATDARADVFVDSFMFWMDTVEMVRVAGHPLVYYSGWVFPIYIFSYLSCLRVVVMPHSPLLSSLGVALQDLPFFFVRVGLIAFFGFVTPILYLMKNLLVSLAFIYFNFMTKLKVFNTERMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVJ3</accession>
    <name>A0A3P9AVJ3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
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            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVJ3"/>
    <dbReference type="Ensembl" id="ENSMZET00005001757.1">
        <property type="protein sequence ID" value="ENSMZEP00005001663.1"/>
        <property type="gene ID" value="ENSMZEG00005001363.1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cytolytic_pore-forming_toxin"/>
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        <property type="entry name" value="SNTX_MACPF/CDC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048997">
        <property type="entry name" value="Stonustoxin-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040581">
        <property type="entry name" value="Thioredoxin_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594">
        <property type="entry name" value="AIG1-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31594:SF16">
        <property type="entry name" value="SI:CH211-281L24.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24674">
        <property type="entry name" value="MACPF_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21109">
        <property type="entry name" value="Stonustoxin_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18078">
        <property type="entry name" value="Thioredoxin_11"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018330809" evidence="1">
        <location>
            <begin position="16"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="SNTX MACPF/CDC-like" evidence="4">
        <location>
            <begin position="49"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Stonustoxin-like helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="SNTX thioredoxin-like" evidence="2">
        <location>
            <begin position="419"/>
            <end position="549"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF21109"/>
        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="554" mass="62604" checksum="0889546C84044834" modified="2019-02-13" version="1">YFSLLLGFLLPRCIAVVKKMWKNTSFFSVFGSHSDMAMDSKPSSTTEVAALGRPFSLGMLYDCRSDSLITGMTLWDHSDLIKDISERPQTSNDFEIIASESIEDKCSALSVDAPLKASFLGHLVQVDGSAKYLNDNKSSRNQARVTLKYKATTKIQELSMNHLGTKNVKHPNVFDQGLATHVVTAILYGAQAFFVFDREVSERENHQHVQGNLKVTIKKIPLLSVEGEGSLKMEGIEKESVDKFSCKFYGDFCLPKPPTTFQDAIKVYQSLPGLLGDKAVPVKVWLVPLESFNSSAPKVVREISIKLVQEAQTLLEDFSELEMCCTDVLRTSTAQQFPQIGKKLKRFKEMCSEFKLDFQKSLAKKLPSIRGGGEEEAELSEILKKRHSSPFSSKNLNEWMDCKEREIYTLMSFTKMMKNTKIISSQNDLYKESLSAEHVVCFVFTSLGKDEPYLSALSRYLRGKTNPDHRVSLFSLISIFFLQDPHTHDAEKEQWYASKEVTGEMRKKVKLFIDFAEANKENKNIKFLTVGLTNETQEGSSIYLYKGGFAHFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AW32</accession>
    <name>A0A3P9AW32_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AW32"/>
    <dbReference type="Ensembl" id="ENSMZET00005001948.1">
        <property type="protein sequence ID" value="ENSMZEP00005001853.1"/>
        <property type="gene ID" value="ENSMZEG00005001485.1"/>
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        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004720">
        <property type="term" value="F:protein-lysine 6-oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF9">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="6">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="58"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="172" mass="18386" checksum="FDF4B906312207AB" modified="2019-02-13" version="1">TTPDNIIYSLYYVLIGQIRLAGSGSTRQCFGRVEIYHSSAWGTVCDDGWDLEDAEVVCRSLDCGTALSATSSALFGQGSGQILLDDVACSGSESSLTECQHRGFGTHNCGHGEDAGVVCSGETWCCSLSPQTLRQCPQQSPSSSPHSERDCCQHTTWPGVSPHFCSRSHPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXS3</accession>
    <name>A0A3P9AXS3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Matrix metallopeptidase 23bb</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXS3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002453"/>
    <dbReference type="Ensembl" id="ENSMZET00005002564.1">
        <property type="protein sequence ID" value="ENSMZEP00005002453.1"/>
        <property type="gene ID" value="ENSMZEG00005001931.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165683"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF120">
        <property type="entry name" value="MATRIX METALLOPEPTIDASE 23A, LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ShKT" evidence="10">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="276"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="371" mass="42344" checksum="C70198305B787EA8" modified="2019-02-13" version="1">YFNINDCGCVKKVTTTFRAQVSTENVTGCFHRCCVNKQLTVDVFGDRAARSKRYAINPLGHKWTHHNITYRIIKFPNTLNVEDTRKAIGIAFTKWSDVSPLTFTEVTDGNATADITIGFYTFNHTDCWWSPLHPCFDGLNGELAHAFLPPRGEIHFDNHEFWILGKSRFSWKQGVWLNDLVQVAAHEIGHALGLWHSRDPQALMHPNATYTGQRNIAQDDVWGIQRLYGCLDKKRVCDPWARLGFCERRKTFMKKNCPQRCDFCYEPLEVVTTATPPAANTKIKMVPRGKVVGFRCGTKSTRSPPKISWYKDGEQILSSIPGYIVMKDRDLRIVANEFNEGVYTCRVHRRGDIVSANSWAIRLKPEQASNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYB3</accession>
    <name>A0A3P9AYB3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cyclin E1</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for the control of the cell cycle at the G2/M (mitosis) transition.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclin family. Cyclin E subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYB3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002634"/>
    <dbReference type="Ensembl" id="ENSMZET00005002748.1">
        <property type="protein sequence ID" value="ENSMZEP00005002634.1"/>
        <property type="gene ID" value="ENSMZEG00005002055.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156256"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000024">
        <property type="entry name" value="G1/S-specific cyclin-E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="232"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="13">
        <location>
            <begin position="326"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="508" mass="56942" checksum="92E907D2F7DD1B92" modified="2019-02-13" version="1">MSGQFPGSPRSGGGALGALGSGLLPRSPRQAEPGFVGRKAARSGGWGRCTSHFYGCLSLNFKSFVVHRFAPTDASTAPTIMRGTREDTEAKSAPAEAPKHTTVRPRKRKADVAIVLPDLDEEVAEMTKKKQRECEPGWSPAADRVSPQRWISTPDQEECPLVPLVNASFPHYSFHTTCVTPVHHAPLPALCWASKDAVWNNMLEKDKSYTRDVHMMDKHPHLQPKMRAILLDWLMEVSEVYRLHRETYHLAQDYFDRFMATQRNVLKSTLQLIGITCLFIAAKVEEMYPPKVHQFAYVTDEACTEDEILSMEIIVMKELKWSLSPQTPVSWLNVYMQVAYLKDADELLLPRYPQATFTHIAELLDLCMLDVRCLEFSNGVLAASALFHFSSLELVETVSALKRVEVEECVRWMVPFAMALREVGSSPMKTFPGISADDMHNIQTHAPYVTWLEKAYSYQEVELQCHGGCPVPSGVLTPPLSSKKTEEPDRGEATVVKIRASMESPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYQ9</accession>
    <name>A0A3P9AYQ9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone H4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 14">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYQ9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002744"/>
    <dbReference type="Ensembl" id="ENSMZET00005002860.1">
        <property type="protein sequence ID" value="ENSMZEP00005002744.1"/>
        <property type="gene ID" value="ENSMZEG00005002148.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000203553"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0164">Citrullination</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 14" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="15">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="100" mass="11026" checksum="85B64BA6AFBAA14C" modified="2019-02-13" version="1">MSGGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYW7</accession>
    <name>A0A3P9AYW7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Extracellular calcium-sensing receptor-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYW7"/>
    <dbReference type="Ensembl" id="ENSMZET00005002986.1">
        <property type="protein sequence ID" value="ENSMZEP00005002870.1"/>
        <property type="gene ID" value="ENSMZEG00005002232.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244874"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06364">
        <property type="entry name" value="PBP1_CaSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000016">
        <property type="entry name" value="Taste 1 receptor member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF528">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018177872" evidence="13">
        <location>
            <begin position="18"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="699"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="811"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="585"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="854" mass="95725" checksum="8D7CDCA489CE027D" modified="2019-02-13" version="1">FWPLIFTLLLVVSFSQADEQVCRQMGDPENPQLSQDGNIILGGIFSFHSSWKDRMDTYLHKPLPLQCTSLSFRGFQFAQAMLFAIEEINNSTDLLPGVSLGYKIYDACGSMARSVKVALTLTNGNEIVAGQSERPCTRPSQVQAIIGETSSSPCMAIATVLGPFYISMISHFATCACLSDKTKYPSFLRTIPSDYYQSRALAHLVKHFGWTWVGAIRTNDDYGNNGMATFTETAQQLGICLEYSVSFFRTDPADKIQKIIDIIKASTSKVIVAFLSHMDMDVLMYGMSQHNLTEYQWVGSEGWIVDSEIAALDIHHILNGAIGLSIPKAHVSGLREFMLNLKPLNSSNNELFIEFWEALFNCRFRQSISSSDIQRECTGHEDVTGVQNSYTDMSVMPIFNNVYKGVYAVAHALHNILSCNKTCNKTVQLDPFTILQHIKNIYFKTKEGEEVYFNENGDPAGKYEIINWQPRENGIVEFVTVGLYDISLAAEKQLYLQNKSLIWARNSKQVPVSVCSEKCPPGTRKVLQKGRPVCCYDCIRCAEGDISNITDSVTCVRCLPEYWSNERRDACIKKEAVFLSYEEIMGALLTAASVFGTCTTAGVVLIFFKHRKTPIVRANNSELSFLLLFSLTLCFLCSLTFIGQPSEWSCMLRHTAFGITFVLCISCVLGKTIVVLMAFRAKLPGSNMMKWFGQTQQRLCVLVFTLVQVIICIVWLTICPPFPFKNFKTFKDKIILECALGSAVGYWAVLGYIGLLSVLCFIFAFLARKLPDNFNEAKFITFSMLIFCAVWITFIPAYVSSPGKFSVAVEVFAILASSFGLLICIFMPKCYIILLKPEKNTKKNMMGKKATHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0W9</accession>
    <name>A0A3P9B0W9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ribosyldihydronicotinamide dehydrogenase [quinone]</fullName>
            <ecNumber evidence="15">1.10.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">NRH dehydrogenase [quinone] 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NRH:quinone oxidoreductase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Quinone reductase 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol</text>
            <dbReference type="Rhea" id="RHEA:12364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15927"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:55458"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.10.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)H dehydrogenase (quinone) family.</text>
    </comment>
    <dbReference type="EC" id="1.10.5.1" evidence="15"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0W9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003524"/>
    <dbReference type="Ensembl" id="ENSMZET00005003655.1">
        <property type="protein sequence ID" value="ENSMZEP00005003524.1"/>
        <property type="gene ID" value="ENSMZEG00005002707.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156563"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001512">
        <property type="term" value="F:dihydronicotinamide riboside quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000030">
        <property type="entry name" value="ribosyldihydronicotinamide dehydrogenase [quinone]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051545">
        <property type="entry name" value="NAD(P)H_dehydrogenase_qn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204">
        <property type="entry name" value="NAD P H OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10204:SF34">
        <property type="entry name" value="NAD(P)H DEHYDROGENASE [QUINONE] 1 ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018106111" description="Ribosyldihydronicotinamide dehydrogenase [quinone]" evidence="20">
        <location>
            <begin position="21"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like fold" evidence="21">
        <location>
            <begin position="13"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="279" mass="31143" checksum="F2BCD157C3A2E08D" modified="2019-02-13" version="1">MFCFVLFFGFVAKKVLIVYAHESPASFNAAAKDAAVATLTAQGCTVEVSDLYAMKFKAAATTEDITGGVKDAENFSYAKEIKLASEEGRLADDIKKEQEKLKEADLVIFQFPMYWSYVPAIMKGWMDRVLGFTYAQEKRYSEGIFKDKKAMLSFTTDCPESVYSDTGINGDINVTLWPLQNGILNYCGFQVFAPQIFWDPATGSPESRSSMLEGWRTRLQNLCGEATVYFAPLDYFDKEKGFLLKPEVKEKYASKESGLTVGIHMGKPLPANSQTKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B387</accession>
    <name>A0A3P9B387_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 5 (11-cis/9-cis)</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547683.1">
        <property type="nucleotide sequence ID" value="XM_004547626.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023010851.1">
        <property type="nucleotide sequence ID" value="XM_023155083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B387"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004370"/>
    <dbReference type="Ensembl" id="ENSMZET00005004570.1">
        <property type="protein sequence ID" value="ENSMZEP00005004370.1"/>
        <property type="gene ID" value="ENSMZEG00005003414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481430"/>
    <dbReference type="KEGG" id="mze:101481430"/>
    <dbReference type="CTD" id="5959"/>
    <dbReference type="GeneTree" id="ENSGT00940000161168"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001523">
        <property type="term" value="P:retinoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000074">
        <property type="entry name" value="Retinol dehydrogenase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF12">
        <property type="entry name" value="RETINOL DEHYDROGENASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="332" mass="37371" checksum="86CBB860FAF238FC" modified="2019-02-13" version="1">MDTQFVYDLLGENAWLYISATFIVLWIVGWLYRDSLEIEDFKNKYVFVTGCDTGFGNLLCKKLDRKGFRVLAGCLTEKGADDLKRVAGPYLKTVLLDVTSQDSIEKAMEWTKQEVGDKGLWGLVNNAGRSLPMGPSEWMKVEDFHSTLKVNMNGVIAMTMTFLPLIKQARGRIVNVASVLGRVAANGGGYCISKFAVESFSDCLRRDIHYFGIKVCIVEPGFFKTAVTSLEPIERELHRLWNQLSPEVKASYGDKYLDKYVNIQRLIMNAVCDSDLTKVTNCMEHALSAAYPRTRYSAGWDAKLVWIPLSYMPSFVVDIALKLVLPRPSKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3V9</accession>
    <name>A0A3P9B3V9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/arginine-rich splicing factor 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Delayed-early protein HRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor SRP40</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Splicing factor, arginine/serine-rich 5</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004550590.1">
        <property type="nucleotide sequence ID" value="XM_004550533.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774441.1">
        <property type="nucleotide sequence ID" value="XM_012918987.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3V9"/>
    <dbReference type="SMR" id="A0A3P9B3V9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004582"/>
    <dbReference type="Ensembl" id="ENSMZET00005004785.1">
        <property type="protein sequence ID" value="ENSMZEP00005004582.1"/>
        <property type="gene ID" value="ENSMZEG00005003550.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005004796.1">
        <property type="protein sequence ID" value="ENSMZEP00005004593.1"/>
        <property type="gene ID" value="ENSMZEG00005003550.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482700"/>
    <dbReference type="KEGG" id="mze:101482700"/>
    <dbReference type="CTD" id="436883"/>
    <dbReference type="GeneTree" id="ENSGT00940000158275"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12595">
        <property type="entry name" value="RRM1_SRSF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12765">
        <property type="entry name" value="RRM2_SRSF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000028">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000138">
        <property type="entry name" value="Serine/arginine-rich splicing factor 5 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF59">
        <property type="entry name" value="SERINE AND ARGININE RICH SPLICING FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="183"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="293" mass="32465" checksum="F11AC12C8EDD9337" modified="2019-02-13" version="1">MSGCRIFIGRLSPSAREKDVERFFKGYGRIRDIDLKRGFGFVEFDDPRDAEDAVYELDGKELCNERVTIEHARVRLRGGRGRGGGGGGGRFSDRYGRGSQNSRSRNPPPMRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASHSDLKNALDKLSGKEINGRKIKLIEAAKKRSRSRSRSESSSRSRSRSRGRSASRSPRRSRSPAKAHNRSRSRSGSPAGGASSPTSKSKEPAKRSSKMSKSATPPSPAPAQRASASRSRSRSRSRSRSPSTDSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3Z3</accession>
    <name>A0A3P9B3Z3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Superoxide dismutase copper/zinc binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3Z3"/>
    <dbReference type="Ensembl" id="ENSMZET00005004810.1">
        <property type="protein sequence ID" value="ENSMZEP00005004606.1"/>
        <property type="gene ID" value="ENSMZEG00005003280.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064791"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="159" mass="17180" checksum="8345C38A6E98514B" modified="2019-02-13" version="1">MFLEVSEFFLEVLSSVCTWFGPGVSDGQVGFSRAVPQGPTTINVSLMSLNSIASGYHVHVLPLNPGSAEPCSNANIQGHFNPLAWNVSQSPPPGVGTVDQYEMGDISGKFGTLNDQNNFEAVYMDPDMSMTGPYSIVGRSLVVHNCNYNILRSIKLFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3Z5</accession>
    <name>A0A3P9B3Z5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">AP3A hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ectonucleotide pyrophosphatase/phosphodiesterase family member 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004552627.1">
        <property type="nucleotide sequence ID" value="XM_004552570.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3Z5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004609"/>
    <dbReference type="Ensembl" id="ENSMZET00005004812.1">
        <property type="protein sequence ID" value="ENSMZEP00005004609.1"/>
        <property type="gene ID" value="ENSMZEG00005003578.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482036"/>
    <dbReference type="KEGG" id="mze:101482036"/>
    <dbReference type="CTD" id="22875"/>
    <dbReference type="GeneTree" id="ENSGT00940000158831"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF79">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE ENPP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018262325" description="bis(5'-adenosyl)-triphosphatase" evidence="23">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="462" mass="51692" checksum="00F99E3A67EF3A16" modified="2019-02-13" version="1">MLFQLVLAFLCGVGVWATENTTTQQEPPPLLLVSFDGFRADYLKRFPMPNLKLLYSQGVLVEQLTNVFITKTFPNHYSLVTGLYAESHGILASRMYDPISKKHFSVSNDTDPLWWNGAEPLWITALDSGYSTAAMMWPGSDVTIRNRTPTHFFPYNRHVTFQERLGNVTNWLLGNATEQRVKFAALYWEEPDKSGHTFGPDNTTAMGKALKEVDDNIGLLISELNRTGLWGRINVVITSDHGMAQCSADRLIRLDECLPEDNYTLVDLTPVAALFPNQSDQADAVFNALSKCHPHMTAYLKKSIPDRLHYQNNVRIQPIILIADEGWTIVKKGNKLPRLGDHGYDNALPSMHPFLAATGPGFRQGYQLNSLETVDVYALMCRLLSVPAQPNNGTLTQARCLLAAEACVDLPLVIGLVVGVLLVLTTITVLFRSLSTRRQSGPRPFRRLQVDYDDDDDDPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B4N9</accession>
    <name>A0A3P9B4N9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat containing 18</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B4N9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004861"/>
    <dbReference type="Ensembl" id="ENSMZET00005005073.1">
        <property type="protein sequence ID" value="ENSMZEP00005004861.1"/>
        <property type="gene ID" value="ENSMZEG00005003763.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156026"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF42">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 18-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="69"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="263" mass="29546" checksum="EBC3BEE7787E125C" modified="2019-02-13" version="1">MIQGKTGYSKGTKVTLKTAKKAIRTTPDGRRRLVLSNMGITIFPKCLFKITFVDELDLSRNLIEKLPENFGDLSSLRWLDLHSNKLVSVPESIGNHRGLTHLNLSNNCLTFSGLPSTLGSLTNLKSLNLGMNQLDDLPLTLVALENLQELGLFDNLFKKLPQFLQGLCNLTKVNVKRNPLSYHQRKDETLLKGKSEHKEDVYLVHESSLCRTCLKREAEGVDSCMSEKKKKSAFPGLVAPNSVATVNQDLWRLREKLECVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6B1</accession>
    <name>A0A3P9B6B1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6B1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005332"/>
    <dbReference type="Ensembl" id="ENSMZET00005005561.1">
        <property type="protein sequence ID" value="ENSMZEP00005005332.1"/>
        <property type="gene ID" value="ENSMZEG00005004133.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159930"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="139"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="369" mass="43038" checksum="B79C396E811DADA3" modified="2019-02-13" version="1">DFEAEIAEIADSAKNNTIQRIVAETPMALLYKKDFKKLPRWDFEDVYSKDTQHRRPTCAQSLRNTQDEKFKKAFLPNIRLFLHKDNINMSEWNRLSHFNSPFGFMNYKYDDVMDSVKLIPKPNKPLLLPKPGGDGCVRCAVVGTGGILNGSKKGVEIDGHDYVFRMNGAITKGYEEDVGNKTSVYVHTAHSITTSLYLLKKYGYKSAPHDEGIKYVLIPEGMRDFQWLKALLRGEKVSAGPYRNKLPRTYYSGQYNESRFYVLHQDFLRYVRNRFLLSPNLNKTYWSLVRPTNGAFTVFLALHTCDIVDAYGFMTDDYVKYPNYYVEKNMSKVIFYANHDYILEKNTWKDLHNRKIIRLFRRTESKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6W2</accession>
    <name>A0A3P9B6W2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6W2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005621"/>
    <dbReference type="Ensembl" id="ENSMZET00005005863.1">
        <property type="protein sequence ID" value="ENSMZEP00005005621.1"/>
        <property type="gene ID" value="ENSMZEG00005004349.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005213"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602:SF4">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="355" mass="39988" checksum="1B0582D1E7C41E80" modified="2019-02-13" version="1">MAACSVEELLAKAEAQEAETLKSISVQKELDLEFDIGNLLACDKNRIEPRDLREKSREDFLRALARDNTQLLVNEIWKQPTERVEEAIVAKLPEPTTRLPREKLPPKPRPPTKWEQFAKLKGIKKKKKTNLVWDETAKEWKRRWGYKRAGDDTKEWLIEVPESADPNEDQFAKRVKAKKERVAKNELNRLKNIARSQKVKIPAVTLTPKASQSKDELARAESVAKTSTASLGRFQDRLPKENPAKKGKKRKFEPLIGNFSNEKQKQLELLKVMDTKKPKLDITKAVNKQMRQEDREEAAAKHKKAAGKKGRKGGSMGGKARGKGGKGKAAGGEEGREEANLGTAARLVGFLECAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B721</accession>
    <name>A0A3P9B721_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-hydroxytryptamine receptor 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serotonin receptor 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552134.1">
        <property type="nucleotide sequence ID" value="XM_004552077.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774803.1">
        <property type="nucleotide sequence ID" value="XM_012919349.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B721"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005698"/>
    <dbReference type="Ensembl" id="ENSMZET00005005948.1">
        <property type="protein sequence ID" value="ENSMZEP00005005698.1"/>
        <property type="gene ID" value="ENSMZEG00005004414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474761"/>
    <dbReference type="KEGG" id="mze:101474761"/>
    <dbReference type="CTD" id="3360"/>
    <dbReference type="GeneTree" id="ENSGT00940000155983"/>
    <dbReference type="OrthoDB" id="5859976at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032098">
        <property type="term" value="P:regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15056">
        <property type="entry name" value="7tmA_5-HT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000046">
        <property type="entry name" value="5-hydroxytryptamine receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001520">
        <property type="entry name" value="5HT4_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF169">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01059">
        <property type="entry name" value="5HT4RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="20">
        <location>
            <begin position="42"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="404" mass="44953" checksum="E615017C580CF49A" modified="2019-02-13" version="1">MNVSAAGQMPAMAELGGESDSMPKRMALICFLSLVMLMSIFGNLLVMVAVCKDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVHQHWIYGETFCLVRTSLDVLLTTASILHLCCIALDRYYAICCQPLVYRNKMTPMRVALMIGGCWVIPTFISFLPIMQGWNSIGIDHLINERRFNNSSNTTSCVFMVNKPYALTCSLVAFYIPLVLMVLAYQRIYITARAHALQISMLQRAGGAGTSAAGTSGGVGASAPDSADHQRNHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNVVDPFIDYTVPEQLWAACLWLGYINSMLNPILYAFLNKSFRRAFLIILCCGRQRYRRPSILGSGAPCTATQINGSTHVLKYCVLHNGNHSEQEKKSLHTHIESHESCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9B6</accession>
    <name>A0A3P9B9B6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxisomal membrane protein 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts with PEX19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004547630.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMZET00005006684.1">
        <property type="protein sequence ID" value="ENSMZEP00005006391.1"/>
        <property type="gene ID" value="ENSMZEG00005004941.1"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
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    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Pmp4"/>
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        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="214" mass="24307" checksum="0A77B31A8636314C" modified="2019-02-13" version="1">MAGPDLIRTLLYTVNNLLQQEKYKAALAVLKGFRNGAVYGAKIRAPHALVMTFLFRSGSLNDKFKAILKATYTHSRNLACFVFTYKGLQALQQKLQGKSLQSHSFLAACVGGWLVFGDNNNINSQINMYLLSRILFALSRLAVEKGFIPQPKHDPFPLFATLVWGIVLWLFEYYPHTLQPSLQSSMNYLYHDSNVWHDISDFLVYNKPRTAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9S5</accession>
    <name>A0A3P9B9S5_9CICH</name>
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        <submittedName>
            <fullName evidence="7">Nudix (nucleoside diphosphate linked moiety X)-type motif 22</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_004545655.2">
        <property type="nucleotide sequence ID" value="XM_004545598.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9S5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006635"/>
    <dbReference type="Ensembl" id="ENSMZET00005006933.1">
        <property type="protein sequence ID" value="ENSMZEP00005006635.1"/>
        <property type="gene ID" value="ENSMZEG00005005126.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101469445"/>
    <dbReference type="CTD" id="84304"/>
    <dbReference type="GeneTree" id="ENSGT00390000017869"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052751">
        <property type="term" value="F:GDP-mannose hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000087">
        <property type="entry name" value="Nudix (nucleoside diphosphate linked moiety X)-type motif 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055295">
        <property type="entry name" value="NUDT22/NUDT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835:SF1">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="181"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="384" mass="42487" checksum="1509685AAD34CFDC" modified="2019-02-13" version="1">MMDPEVSVLLHCAHWHGLLESQVQVELSERFNRQTDLALERHIDEVWTKRVSKEPWLFNGAKFRLHSFCLADPQNPPSTPLSHGTIFHHTEDQNNQGQRDLGEIHNRCISQTENAEGASNHDYREFNGIADKLPPHPAPLLTLRLGLTCYKDYLGTNWSCGVAKLRQRGEAEFGDPLTLLAQPLGVGAILCTSNGQVVMIRRSQKVAEAGGLLDIPGGHPEPKAVCERLGQRVCEEQIGIAMMERKPETIVSELFSSVCAEIRDEVNIPLSSLGPPVLMGVALNHTSAGRPSAEFYVSCSLNSDEVRKLYWKGGVEASESTEVVFVSRTEVLQLDRSSPLWSELCPSAKGAVLLYQTVKPDVVPDQRGRGDAKLTPPHVHKETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAT1</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
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        <name type="common">zebra mbuna</name>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAT1"/>
    <dbReference type="Ensembl" id="ENSMZET00005007316.1">
        <property type="protein sequence ID" value="ENSMZEP00005007009.1"/>
        <property type="gene ID" value="ENSMZEG00005005371.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001663"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003360">
        <property type="entry name" value="US22-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02393">
        <property type="entry name" value="US22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018018102" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="171" mass="19712" checksum="61C8E5B2E25733F4" modified="2019-02-13" version="1">DGLLSLVLWRWLFCVVPCACEYLKWVKDFVSKNKSMCVHLKKPSGADLWIEELENTKYNGDDDEVNAWGKFYLPEIVKMQVIGVVKGTSCPCDELVLMTQELHLVASSFLELCDKTIEYPASKRYYNGEAFKDMTEEDWKKVKMSDVGRKLQEEHKKLVNETQSAFVSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD31</accession>
    <name>A0A3P9BD31_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD31"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007788"/>
    <dbReference type="Ensembl" id="ENSMZET00005008106.1">
        <property type="protein sequence ID" value="ENSMZEP00005007788.1"/>
        <property type="gene ID" value="ENSMZEG00005005946.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000178451"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052297">
        <property type="entry name" value="RING-CH-type_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471">
        <property type="entry name" value="MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="75" mass="8628" checksum="C214C9B555A9DC32" modified="2025-10-08" version="2">MDTKKDRCRICYSSDASPSNPLLSPCLCSGSLLFIHLDWLSFRAVQRCEICKGRVVVDPNVFDLKDCYMRIRQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEA5</accession>
    <name>A0A3P9BEA5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Pore-forming subunit of a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Voltage-gated sodium (Nav) channels consist of an ion-conducting alpha subunit which is functional on its own associated with regulatory beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Cell membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005008230"/>
    <dbReference type="Ensembl" id="ENSMZET00005008558.1">
        <property type="protein sequence ID" value="ENSMZEP00005008230.1"/>
        <property type="gene ID" value="ENSMZEG00005006202.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167352"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13433">
        <property type="entry name" value="Na_channel_gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000001">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000006">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000004">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000005">
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        <property type="entry name" value="Na_channel_asu"/>
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        <property type="entry name" value="VGCC_Ca_Na"/>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
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        <property type="entry name" value="SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA"/>
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    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00520">
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    <dbReference type="Pfam" id="PF06512">
        <property type="entry name" value="Na_trans_assoc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NACHANNEL"/>
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        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
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    <keyword evidence="14 20" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <keyword evidence="7 20" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="129"/>
            <end position="150"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="1605"/>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEZ6</accession>
    <name>A0A3P9BEZ6_9CICH</name>
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        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSMZET00005008664.1">
        <property type="protein sequence ID" value="ENSMZEP00005008331.1"/>
        <property type="gene ID" value="ENSMZEG00005006239.1"/>
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        <property type="entry name" value="ERICH3"/>
    </dbReference>
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        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23034:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15257">
        <property type="entry name" value="DUF4590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4590" evidence="2">
        <location>
            <begin position="282"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="120"/>
            <end position="182"/>
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            <begin position="222"/>
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            <begin position="387"/>
            <end position="1156"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF15257"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="1448" mass="159557" checksum="695851394C5652A7" modified="2019-02-13" version="1">NTKAFPGQLLSTYNSLTDKHLAGYFSSTRIRRHLQRAGLITRSGRIVPDKEYRHKLIQRAHQRHVRECLAQAIFHKVLEMERLHQIEIKRKLEEFARRERVHKIKVERSKRYEEGIVHILSPHPPEGARGIQKQHSGPEGEHSDSSESPSSSRPNTAPGKMQRPVRLKPIHSNSTTASVRHSSPYRLLQSSHDNHLPFNCTASHGISPYCLPVINNFVTPVPPATKRKERGLKGTASSTVRGRRLRPTTASSGADDAPLLRSSVHQSRVCVNMVYFGKTVRLSSDLTDMRDDVKVFQQHCGGENLCVYKGKLHEGETFQFISRRHRGFPFSLTFFLNGLQVERLSSCCEFKHRKGSRLGGKHGHFGFTGVEGASPCYKCIIAMGLDKKPTPPPKRIKEDTRREESVNSPKDEGEMETERTGEDAGSHLEGETSEPQNMETPVKEERALDEEKDDKAAEEEDKSEETGEALHPSKEENVTQDDKTTEHLEETPAETADTEAAEEGKEKTAEETDVQHDETGQGAKSSEEDESSEPDKKTDETAAPDNAEAVTARETIEIKAESSKEQEALSYEEAPVSDAEKEEQADSEDRAAGSETEVNAENSSSSPSGSGETTVEKIGDRGEENAIEESSKDDIKEEQVLEDESHEQCELPEERRTGAPEETGEKEDKEKTEEGGKEEEEKQTHVTSDKGEDENTGKRDDDDEKVKNEEEGNEESKEDEGTDKQENTAESSENGFKTKEDEEEAVKSLSEEDKVADDEKVEEKTENDENSECVENKLEESEVGDKSEGDNDNESKPAVQENDDEAEKSENLNKAEKSEDKEKHDEEDDKEKDISEAPVEEGEEISETTEEAEKSADVGANEAADGTKSADETPEAESVEQDAGKTSNTSEKEEINAENGEISTEAESNNHEDDGESQLKDKNDLKAKEEGDEESKADGPADDESADIKEVAVESEEGAKKHDADEVDQAPGADEVERDAEGDSVEKNDESTPSNSQPETAGTEMKAEPKLGDRKDGEEAEQDQNGNKSDCDNENKEPDLVKKESSAEENVDEVAAVSSGNQEQSPVAVDLDVLASKLDEESKDTKSDICPQTDENAVGGDLSAADGENGVDAEDASKASEEGASVLLKPQNNEADYTEETVAAGRESPEALAAEDSTDLVSNWVNKHQSSKFFETFVEPLEDMREEITDTPASSSNKEETKSTELPGSDSPLKMVRVSEDEVKAYRDAEDELQVEEKAEVKDLILKPQTEQSEEESAALQKMRSEEHKGSMGSLQECNGQESAEKGINEENAFSKTEVESTSGSLHSATEKPASVSKSQPDEKTVDNNFNVTEPQTEEGNQSTSPLGTEDVNETWGKADEQSREVTETTDFTTSKSDDGSPEDSRNEEIEGKASDRSVSRDRKDLQLIEDIKHTLSKDRLSAFSVDDTLFAHSSYPLLTAASAESGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFU4</accession>
    <name>A0A3P9BFU4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008621"/>
    <dbReference type="Ensembl" id="ENSMZET00005008961.1">
        <property type="protein sequence ID" value="ENSMZEP00005008621.1"/>
        <property type="gene ID" value="ENSMZEG00005006565.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157430"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14569">
        <property type="entry name" value="DSP_slingshot_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11652">
        <property type="entry name" value="SSH-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="12">
        <location>
            <begin position="250"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="309"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
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            <begin position="371"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="706"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="781"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1176"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
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    </feature>
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            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="957"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="984"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1181"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1243"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1286" mass="142138" checksum="D7EABC9826E62A7E" modified="2019-02-13" version="1">MALVTVQRSPTPSTTSSPCVSESGSGEDDCRFHLRSISESFLTVKGAALFLPRGNSPTQNSAPRISQRRNKHTGDLQKHLQTMFTVLRPEDTIRLAVRLESACPQVTRYMVVVSTNGRQDTEESIVLGMDFVSSDSCCTVGLVLPLWSDTMIHLDGDGGFSVSTVNRVHVFKPVSVQAMWSALQSLHKACEVARCHNYYPGSLFLTWVSYYQSRVSSSQLCINEWNAMQDVESHRANSPVLFTDLPTERERTERLIKTRLREIMMQKDLENVTSKEIRTELEIQMVCNLREFKEFIDNEMIVILGQMDSPTEIFDHVFLGSEWNASNLEELQNSGVRYILNVTREIDNFFPGMFEYHNIRVYDEEATNLLEYWNDTYKFITKAKKAGAKCLVHCKMGVSRSASTVIAYAMKEYGWNLDTAFDYVKERRAVTKPNPSFMKQLEEYQGILLASKQRHNKLWRSHSDSDLSDRLDSKPSSPSLNRADSHNNNTSSPSVHHFLGVAVLQALYPEPEDSHALSNGVCDSLVQEVRSDCADPRLLPLPRPRAATVVPEEKQGSSASVAITVPVALPLPPPSLHILPPTPELQRAHRDTPTHLSCSVGKPEELFLILPDRSSSEEVSPLTLGSTDSDMINQSLSDLTNNSHTPLSPATPTSSPPISAFAPSDDNNNNPSELDTRGEADGSSTHSTDSIDFFSAREKFLGLAKDGRHRTLSEQAQQRTSLSTDRETEVSEDEEEQRNEMSQESDDSSDKTSPDRIHHTHHDNGISVRHIVTEIEAISHPAASLQTPSSSSSSPLPPSSHSPQVIRPEHQEEGESSEVTHTSSTPPSHPQPPTTLLCDWPAGSVRRATKQLEQKLKQELEMVACQRSPLHSPSSEQPPVILSVSSEHVLLHSPMHAAEQRITQGENMAVSANATSKDEEKHTGSHKRPDFSGTSDLQDLSCSPKSDISQVSGAIPVSVHTSTDSHTVTSSLASAEQLSASSQDTSAQSLRRGQLHSQNLQDCSNLMTLDGVTLQESDTDESSRVRQEGCGPVCAAQKRLARGSQELEKIQQTLRELQAFLHEGITLETADSRGQELGQPQGPRDAMDTDPESYKGVSFEESPPALKVGQQLLEKQEQRSLLEPTEWHRATELEARIRQAGLTPPSLMKRSASLAKLDCLELSAHDLSSLDLRTHNRATLPHSPDSPSSPQSHPDDTWKKQKVLAQRPCSERTGSCSDDTSPPPLGLSPSTRGERGEREESENSSSSNSTVPASRQPGRGHSSRRSRKASAEKKQQRAVTLLYNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ25</accession>
    <name>A0A3P9BJ25_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Family with sequence similarity 160 member A1b</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ25"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009897"/>
    <dbReference type="Ensembl" id="ENSMZET00005010260.1">
        <property type="protein sequence ID" value="ENSMZEP00005009897.1"/>
        <property type="gene ID" value="ENSMZEG00005007490.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182936"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF6">
        <property type="entry name" value="FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26980" checksum="B62AB4EE98911C92" modified="2019-02-13" version="1">MMASVVIGGHRKKSLTLRGVDPETCMIVFKNHWAQVIFLFTPASSSSSLASAVQNYVEHMLFLLMEEEAGGAMGPILEFVVLEGVMERLFLWSLRRQFTEDMKLEQLRMYQMLLSQAKQPLLHHKPVLRPLMMLLLGHSPPPLGASPILTPGLPVLLLNQLCVALVKDPSVLELFFHTSEDQGAANFLLFSLLIPYTHRQGLVGQQARDALLLIMSLSASEPRVAQHIAENTYFCPVSKCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJT4</accession>
    <name>A0A3P9BJT4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560781.1">
        <property type="nucleotide sequence ID" value="XM_004560724.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJT4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010219"/>
    <dbReference type="Ensembl" id="ENSMZET00005010588.1">
        <property type="protein sequence ID" value="ENSMZEP00005010219.1"/>
        <property type="gene ID" value="ENSMZEG00005007705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467016"/>
    <dbReference type="KEGG" id="mze:101467016"/>
    <dbReference type="CTD" id="84516"/>
    <dbReference type="GeneTree" id="ENSGT00390000015360"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000014">
        <property type="entry name" value="dynactin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="182" mass="20159" checksum="5170405558FDC6A5" modified="2019-02-13" version="1">MELSEILYNKAEYIETASGNKVSRQSVLCGSQNIVLNGKTIVMNDCIIRGDLANVRVGRHCVVKSRSVIRPPFKKFSKGVAFFPLHIGDHVFIEEDCVVNAAQIGSYVHIGKNCVIGRRCVLKDCCKILDNTVLPPETVVPPFTVFSGCPGLFSGELPECTQDLMIDVTKSYYQKFMPLSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLZ9</accession>
    <name>A0A3P9BLZ9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Akirin 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012774573.1">
        <property type="nucleotide sequence ID" value="XM_012919119.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLZ9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010959"/>
    <dbReference type="Ensembl" id="ENSMZET00005011338.1">
        <property type="protein sequence ID" value="ENSMZEP00005010959.1"/>
        <property type="gene ID" value="ENSMZEG00005008231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486208"/>
    <dbReference type="KEGG" id="mze:101486208"/>
    <dbReference type="CTD" id="79647"/>
    <dbReference type="GeneTree" id="ENSGT00940000158787"/>
    <dbReference type="OrthoDB" id="10039914at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014839">
        <property type="term" value="P:myoblast migration involved in skeletal muscle regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902723">
        <property type="term" value="P:negative regulation of skeletal muscle satellite cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010592">
        <property type="term" value="P:positive regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010759">
        <property type="term" value="P:positive regulation of macrophage chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF9">
        <property type="entry name" value="AKIRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="187" mass="21050" checksum="82D59B2C822E063D" modified="2019-02-13" version="1">MACGATLKRSMEFEALLSPQSPKRRRCNPLPGTSSTPSPQRCSLRPAVDSPAHSMSPPATGGEHRLTPEQIFQNLRQEYSRIQRRRQLEGAFNQTEACSSSDAPSPSSSLNAPSSPPGASRKDQPSFTLRQVSYLCERLLKDHEEKIREEYEQILNTKLAEQYESFVKFTQDQIMRRYGARPASYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BN35</accession>
    <name>A0A3P9BN35_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dehydrogenase/reductase SDR family member 11</fullName>
            <ecNumber evidence="3">1.1.1.270</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">17-beta-hydroxysteroid dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">3-beta-hydroxysteroid 3-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Estradiol 17-beta-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Short-chain dehydrogenase/reductase family 24C member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>17beta-estradiol + NADP(+) = estrone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34787"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36836"/>
            <dbReference type="ChEBI" id="CHEBI:47788"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.270"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Steroid biosynthesis; estrogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BN35"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011359"/>
    <dbReference type="Ensembl" id="ENSMZET00005011753.1">
        <property type="protein sequence ID" value="ENSMZEP00005011359.1"/>
        <property type="gene ID" value="ENSMZEG00005008521.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00840000129887"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05343">
        <property type="entry name" value="Mgc4172-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="261" mass="28491" checksum="6F9B1DA166CA30F4" modified="2019-02-13" version="1">MERWRGRVALVTGASVGIGAAVAVELVRLGMKVVGCARDVGKIQKLAAECQSAGHPGVLVPFKCDLTKEEEILSMFATIKEQHKGVDVCINNAGLAHPEALLNGKTSGWKNMWDVNVLALCICAREAYQSMKERNVDDGHIININSVCGHQVFPNADGHFYTATKYAVTALTEGLRKELRAENTHIRATSISPGFVETEFVSRLYRDNSDKAAAVYTDYKSLEAKDLVHAVTYVLSAPPHVQGNMKMKPGDVLTESELNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQE7</accession>
    <name>A0A3P9BQE7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc transporter ZIP9</fullName>
            <shortName evidence="7">ZIP-9</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Solute carrier family 39 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Zrt- and Irt-like protein 9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">trans-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQE7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012148"/>
    <dbReference type="Ensembl" id="ENSMZET00005012576.1">
        <property type="protein sequence ID" value="ENSMZEP00005012148.1"/>
        <property type="gene ID" value="ENSMZEG00005009126.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010094"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF4">
        <property type="entry name" value="ZINC TRANSPORTER ZIP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="269" mass="28545" checksum="6E2736E049A46587" modified="2019-02-13" version="1">MDGGLIITFISVAMFVGSFLFGFIPLLLFWKLAEQLELFVSILGAGLLCGTALAITIPEGVGLLEDSWKSEQESSNIKENGTVAERGPPRFLIGVALTLGFTFMFVVDQIGSYLSTHQTTCLSNSVHFTATLGLVIHAAPAAFGLVSFLMHGGLEKKFIQGHLLAFSAAAPIVAIATYFILYASGSSSENQLSATGVGMLFSAGTFLYVATVHVLPEISSSRTDELPLDSEQQSGAEAHQQRHLGLLESLTLIIGVGLPMLLALGLHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQS2</accession>
    <name>A0A3P9BQS2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_004545891.1">
        <property type="nucleotide sequence ID" value="XM_004545834.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQS2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012278"/>
    <dbReference type="Ensembl" id="ENSMZET00005012710.1">
        <property type="protein sequence ID" value="ENSMZEP00005012278.1"/>
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        <location>
            <begin position="64"/>
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        </location>
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        <location>
            <begin position="1"/>
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        <location>
            <position position="189"/>
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            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
    <sequence length="331" mass="38195" checksum="6BBEE5D97F95AD88" modified="2019-02-13" version="1">MQNKENYEPRGLQRPFATPNLSGPQRVVVKQRADTMKNTVTGPARECIGSSSSSASKKISIDDFDIGRPLGKGKFGNVYLARVKKLQAIVALKVLFKSQMEKEGVEHQLRREIEIQAHLKHPNILRFYNYFHDRKRVFLVLEYAPRGEMYKELQRCGRFDDRRTATYMEEISDALMYCHEKKVIHRDIKPENLLLGYRGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGHTHSEKVDLWCIGVLCYECLVGNPPFETASHSETYKRIMKVDLKFPKVVSDGARDLISKLLRHNPIDRLPLQSVIDHQWVRANSHRLLPPTCPVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BS44</accession>
    <name>A0A3P9BS44_9CICH</name>
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        <recommendedName>
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        </recommendedName>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
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        <property type="entry name" value="Znf_B-box"/>
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    <dbReference type="PANTHER" id="PTHR25465">
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
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        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="236" mass="27385" checksum="BB86B910E416E3D1" modified="2019-02-13" version="1">MCLVSYCQTHLEPHQRISALKKHKLIDPVQDLESRICRDHGEPLELICRLDQRFLCRSCKCSDHKTHETVSLEDEAEMRKSQLRLENNSMDQMIQEREQKIQELQQSVKTSRSKAEEALSYSRKVMTALVQHIKTEFTRLSEAIETKRRNRVKSKCNKDSLPLVLLLKFPRVNFCNPLNLSLLQSLFCECQFDIPQRCSDSSILSPSHLLQFLDLLCVSFLLHLPNQEVQVDSSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTI1</accession>
    <name>A0A3P9BTI1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome assembly chaperone 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PSMG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561868.2">
        <property type="nucleotide sequence ID" value="XM_004561811.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTI1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013237"/>
    <dbReference type="Ensembl" id="ENSMZET00005013689.1">
        <property type="protein sequence ID" value="ENSMZEP00005013237.1"/>
        <property type="gene ID" value="ENSMZEG00005009949.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101484161"/>
    <dbReference type="CTD" id="8624"/>
    <dbReference type="GeneTree" id="ENSGT00500000044950"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR016565">
        <property type="entry name" value="Proteasome_assmbl_chp_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15069:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16094">
        <property type="entry name" value="PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="279" mass="31254" checksum="E828D8AF33F450D0" modified="2019-02-13" version="1">MATFFGEVLSVYSRAVEEDDDELDENEEDEQIRRELEEKREVHLHWSPEVSESLKSGNKLQCSDFILAVGQNASSFLSVHILSTPNWDTIGRASAWNERSRAVTGQSCEESACVFYRHKDNPTVLICQVSCYVAEDQLFQWTEKVFDCLQLRELNVTVLSDTSVADYKTADYLGGSSAPFLRSLHTSAFGDQPVCQSLEQPNIVTGLAAAVLNHCQVHRIAAVVYQCYSDVIGPDSVTMETYKPVLIKLGRSIQLDPSPSTDALRKFVRTTDLQSNLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTW3</accession>
    <name>A0A3P9BTW3_9CICH</name>
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        <submittedName>
            <fullName evidence="16">RNA binding motif protein 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTW3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013347"/>
    <dbReference type="Ensembl" id="ENSMZET00005013801.1">
        <property type="protein sequence ID" value="ENSMZEP00005013347.1"/>
        <property type="gene ID" value="ENSMZEG00005010035.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156617"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12755">
        <property type="entry name" value="RRM2_RBM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000110">
        <property type="entry name" value="RNA-binding protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055494">
        <property type="entry name" value="DUF7066"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034993">
        <property type="entry name" value="RBM5_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF21">
        <property type="entry name" value="RNA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23217">
        <property type="entry name" value="DUF7066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="95"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="228"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="14">
        <location>
            <begin position="759"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="520"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="727"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="688"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="831" mass="92580" checksum="C35AE06AA3A77EF0" modified="2019-02-13" version="1">MGTDRRISRSERTGRYGSDMRKHDPECYGKRSRDVEKDYDRRWVHDRYKDYCDERRDQDSPERSRKRRSSSRSDDEYDGEYPEQDYKMEQEEESKTIMLRGLPVHVTEDDMRTALEQLQGPQPVDIRLMKKRTGISRGFAFVEFYHLQDSTRWMETNQNKLVIQGKTIAVHYSNRKQKFENWLCNACGLYNFRKRLKCFRCGASKVGDSTGVNGLNVECQQPGEYSGDTIILRNIASLSTVDGILNLLAPHANLSTNNVRLIKDKQTGQNRGFAFVQLSSPLEASQLLTILQSLQPPLKLDGKTVGVDFAKSARKDSVPPEGIRASALSVASTAIAAAQWSSSQLQQSSGATSDQIAFPESYANMWPQQPEGLVPVVGEGLLGAAPGMASVIPASTAVVLSQAAQVYHPIIISQPAVQTHPLAVAAQQAASVCTTSLTTPASSTVAATICAGSTANTTAVPDTSMYQYDESSGYYYDPQTGLYYDPGSQYYYNSETQQYLYWDNEKQAYIPALSESGTNTEQASTASSAATSLSTGGKEAKEKKEKPKNKSAQQIAKDMERWAKSLNKQKESIKSTAQGLGSFKDEDRKESAAADAGFFLFEKKQIGSFEMPSLMTEQIKLEDEISSKSDLVAAYNGDSDPDDNGSDRAADEEGKMTDWKRMVCLLCRRQFPTKDALLRHQQLSDLHKKNLEMERRAKLSEMEVEELERKEAELKYRDRAAERREKYGIPEPPAPKKKFYKAPSPTVNFEQPTKDGLTSDNIGSKMLQAMGWQEGKGLGRHQQGITVPISASLRTKGTGLGIKGSSYELSPSDTYKDAVRKAMFARFTEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTX7</accession>
    <name>A0A3P9BTX7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTX7"/>
    <dbReference type="Ensembl" id="ENSMZET00005013816.1">
        <property type="protein sequence ID" value="ENSMZEP00005013362.1"/>
        <property type="gene ID" value="ENSMZEG00005010046.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282517"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:003074">
        <property type="entry name" value="Immunoglobulin heavy variable 11-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="104" mass="11783" checksum="E0A3920972B5BB01" modified="2019-02-13" version="1">MTAQWILTQSEPAVKRPGESHRLTCTASGYTFGDYSLVWVRQAPGKGLEWIAYIYWGDGSTSYSQSVQGKFTASRDNSREQLFLQMNSLKTEDSAVYYCARHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BV82</accession>
    <name>A0A3P9BV82_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deubiquitinase DESI2</fullName>
            <ecNumber evidence="4">3.1.2.22</ecNumber>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Desumoylating isopeptidase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PPPDE peptidase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Palmitoyl protein thioesterase DESI2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein FAM152A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">S-depalmitoylase DESI2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="4"/>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="RefSeq" id="XP_004539994.1">
        <property type="nucleotide sequence ID" value="XM_004539937.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BV82"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013885"/>
    <dbReference type="Ensembl" id="ENSMZET00005014355.1">
        <property type="protein sequence ID" value="ENSMZEP00005013885.1"/>
        <property type="gene ID" value="ENSMZEG00005010469.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471312"/>
    <dbReference type="KEGG" id="mze:101471312"/>
    <dbReference type="GeneTree" id="ENSGT00940000164487"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1720.30:FF:000001">
        <property type="entry name" value="desumoylating isopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF41">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PPPDE" evidence="18">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="197" mass="21968" checksum="687AB85295E59E61" modified="2019-02-13" version="1">MANEPVILNVYDMYWINEYTSNLGIGVFHSGIEIYGREFAYGGHPYPFSGIFEINPGNAAELGETFKFKEAIVLGTTDFTEEDIDKIMEELGKEFKGNAYHLMHKNCNHFSSSLSELLCGREIPRWVNRLAYFSSCIPFLQSCLPKEWLTPAALQSHISLGLHKEEHNESSDEDPSSPSGATAAGSGSSHSCRHTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BV94</accession>
    <name>A0A3P9BV94_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Gasdermin-E</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gasdermin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547887.2">
        <property type="nucleotide sequence ID" value="XM_004547830.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BV94"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013842"/>
    <dbReference type="Ensembl" id="ENSMZET00005014311.1">
        <property type="protein sequence ID" value="ENSMZEP00005013842.1"/>
        <property type="gene ID" value="ENSMZEG00005010434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463613"/>
    <dbReference type="KEGG" id="mze:101463613"/>
    <dbReference type="GeneTree" id="ENSGT00940000155880"/>
    <dbReference type="OrthoDB" id="8815334at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040460">
        <property type="entry name" value="Gasdermin_pore"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041263">
        <property type="entry name" value="Gasdermin_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042377">
        <property type="entry name" value="GSDME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15207:SF3">
        <property type="entry name" value="DEAFNESS, AUTOSOMAL DOMINANT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15207">
        <property type="entry name" value="NONSYNDROMIC HEARING IMPAIRMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04598">
        <property type="entry name" value="Gasdermin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17708">
        <property type="entry name" value="Gasdermin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1210">Necrosis</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Gasdermin pore forming" evidence="12">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Gasdermin PUB" evidence="13">
        <location>
            <begin position="281"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="463" mass="51162" checksum="5E688E49742B045D" modified="2019-02-13" version="1">MFSKATANFVREIDPEGLLIHVSRVNDSHKLVPMALVIKRKRWFWQRPRYQPTDFTLGDLLLGDKELIPGVSESEFLTYKGTYGAKLASDLGPEAGSASIRLEGRGTTKLQSCFGQLKKEEVNVKKLLLDSDNRSVDMQHVLVRQIEKRAEVVGLVKERIFTTSPCSITQTKVEECTFQGVLGLVGMLGSSVKVCVKDSNSIEIDSDVSVEIPSGTVIAYSILELEVKKDGQYYICLQPGAIGGFESDSISRSWPSDDCFDTVDGKCNEQKVPQKPPLIALHNESQEKVLSPLAKLPQPTRWALFKKLQETLNDSAALSYLQLVLEDLCSNEIHNGTPKEEQPSAESPTESTLNAAHLLVSAMEELPKETLELLSKSAPDFLQAFNMLVCKLKSSDVLNIQSLPALLQDNQAFQLAEQLLSSASVMLRRDADLLWMETRDNAGVLPVVLFLSIHGLCLLCNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVS7</accession>
    <name>A0A3P9BVS7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Caveolin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <location evidence="10">Caveola</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the caveolin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544887.1">
        <property type="nucleotide sequence ID" value="XM_004544830.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVS7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014017"/>
    <dbReference type="Ensembl" id="ENSMZET00005014489.1">
        <property type="protein sequence ID" value="ENSMZEP00005014017.1"/>
        <property type="gene ID" value="ENSMZEG00005010569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484108"/>
    <dbReference type="KEGG" id="mze:101484108"/>
    <dbReference type="CTD" id="859"/>
    <dbReference type="GeneTree" id="ENSGT00950000183006"/>
    <dbReference type="OrthoDB" id="5917823at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070836">
        <property type="term" value="P:caveola assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042693">
        <property type="term" value="P:muscle cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060035">
        <property type="term" value="P:notochord cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018361">
        <property type="entry name" value="Caveolin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF16">
        <property type="entry name" value="CAVEOLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01210">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="152" mass="17496" checksum="C6E1BC22B2E4ACC9" modified="2019-02-13" version="1">MADQYQYNTNEEKFVKDSHTKEIDLINRDPKQINEDVVKVEFEDVIAEPDGTHSLDGVWKLSYTTFTVSKYWCYRVLSAVFGIPVALLWGFLFACISFCHIWAVVPCIKSCLIESQCVSRIYSLCIQTFCDPFFEALGKIFSSVRVALRKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWY5</accession>
    <name>A0A3P9BWY5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Adapter molecule crk</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CRK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551266.1">
        <property type="nucleotide sequence ID" value="XM_004551209.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BWY5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014362"/>
    <dbReference type="Ensembl" id="ENSMZET00005014841.1">
        <property type="protein sequence ID" value="ENSMZEP00005014362.1"/>
        <property type="gene ID" value="ENSMZEG00005010819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468680"/>
    <dbReference type="KEGG" id="mze:101468680"/>
    <dbReference type="GeneTree" id="ENSGT00820000127055"/>
    <dbReference type="OrthoDB" id="9204160at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000145">
        <property type="term" value="P:regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09926">
        <property type="entry name" value="SH2_CRK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11759">
        <property type="entry name" value="SH3_CRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11758">
        <property type="entry name" value="SH3_CRK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000065">
        <property type="entry name" value="adapter molecule crk isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000026">
        <property type="entry name" value="adapter molecule crk isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035458">
        <property type="entry name" value="CRK_SH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035457">
        <property type="entry name" value="CRK_SH3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF8">
        <property type="entry name" value="ADAPTER MOLECULE CRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4 14" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="251"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="319" mass="35162" checksum="4264DCF5FCC5FAA1" modified="2019-02-13" version="1">MAGNFDAEDRASWYWGRLSRQEAVSLLQGQRHGVFLVRDSITIPGDYVLSVSENSRVSHYIVNSISNNRQSGSGLAPSRFRIGDQEFDGLPALLEFYKIHYLDTTTLIEPVNRGRQSGLISPPAVGPPQQTEEGEYVRALFDFPGNDYEDLPFRRGDILRVLEKPEEQWWHAKNQEGRVGMIPVPYVERFRPSSPTAASLSPVPAGTGQGGHVGGVMGSTDGTGSPQATALGEPGPYAQPVVNTQLPNLQNGPVYARAIQKRVPNAYDKTALALEVGDTVKVTKINVNGQWEGECKGKRGHFPFTHVRLLEQYYPDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BX58</accession>
    <name>A0A3P9BX58_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Urocortin-3</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds with high affinity to CRF receptors 2-alpha and 2-beta.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545392.1">
        <property type="nucleotide sequence ID" value="XM_004545335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BX58"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014442"/>
    <dbReference type="Ensembl" id="ENSMZET00005014924.1">
        <property type="protein sequence ID" value="ENSMZEP00005014442.1"/>
        <property type="gene ID" value="ENSMZEG00005010867.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101465616"/>
    <dbReference type="GeneTree" id="ENSGT00940000169986"/>
    <dbReference type="OrthoDB" id="9949770at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051431">
        <property type="term" value="F:corticotropin-releasing hormone receptor 2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000187">
        <property type="entry name" value="CRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024270">
        <property type="entry name" value="Urocortin_II/III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17575">
        <property type="entry name" value="UROCORTIN-2 AND 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17575:SF1">
        <property type="entry name" value="UROCORTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00473">
        <property type="entry name" value="CRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018258856" evidence="8">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor" evidence="9">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="123" mass="13615" checksum="68B9F6F99C95A436" modified="2019-02-13" version="1">MRSVRACFCLALLLPLCVQSRRSSLAVAKLNEDTERDMLAVDILNRNGALSSLLRSQHHLVLRRAPRPASQVPKRAQQASRFALSLDVPTSILSVLIDLAKNQDMRTKAAANAELMARIGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXU9</accession>
    <name>A0A3P9BXU9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Chemokine (C-X-C motif) receptor 4a</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXU9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014790"/>
    <dbReference type="Ensembl" id="ENSMZET00005015278.1">
        <property type="protein sequence ID" value="ENSMZEP00005014790.1"/>
        <property type="gene ID" value="ENSMZEG00005011138.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005015284.1">
        <property type="protein sequence ID" value="ENSMZEP00005014796.1"/>
        <property type="gene ID" value="ENSMZEG00005011138.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244848"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000063">
        <property type="entry name" value="C-X-C chemokine receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001277">
        <property type="entry name" value="CXCR4/ACKR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF594">
        <property type="entry name" value="C-X-C CHEMOKINE RECEPTOR TYPE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00645">
        <property type="entry name" value="CXCCHMKINER4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="63"/>
            <end position="88"/>
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            <begin position="100"/>
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            <begin position="140"/>
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            <begin position="316"/>
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            <begin position="79"/>
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            <begin position="363"/>
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            <begin position="370"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="384" mass="42123" checksum="50FCEAFAFAD2BA5B" modified="2019-02-13" version="1">MKINLSFTQRRSAAVSTMSYYEHIIFEDYYNDTSSGSGSGELGVDLEEPCGVEHMTTTELQQVFLPVIYALIFILGITGNGLVVVVLGCQRRSKCSLTDWYRLHLSAADLLFVLSLPFWAVDAALADWRFGAATCIGVHVIYTVNLYGSVLILAFISLDRYLAVVRATDTNTSGLRQLLAHKLVYVGAWLPAGLLAVPDLIFARTQEGGEGSTLCQRFYPEENAPLWVAVFHLQLVLVGLLIPGLVLLVCYCVIVTRLTRGPLGGQRQKRRAVRTTIALVLCFFVCWLPYGAGISVDALLRLEVLPRSCRLEAALGVWLSVAEPMAFAHCCLNPLLYAFLGAGFKNSARRALTLNRASSLKVLPRRRPGTSTTTESESSSLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BYM0</accession>
    <name>A0A3P9BYM0_9CICH</name>
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        <submittedName>
            <fullName evidence="9">Regulatory factor X, 1a (influences HLA class II expression)</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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            <taxon>Maylandia zebra complex</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="Ensembl" id="ENSMZET00005015477.1">
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        <property type="gene ID" value="ENSMZEG00005011253.1"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RFX1_trans_act"/>
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    </dbReference>
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        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="8">
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            <begin position="182"/>
            <end position="257"/>
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    </feature>
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            <begin position="298"/>
            <end position="310"/>
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        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="722" mass="80807" checksum="4A8D03C8E8451F1D" modified="2019-02-13" version="1">HSNDSVSDSSPPPAVVQTGVPTQVVQQVQTAQQVKFAHIHGYVRLCYIMLFSLLLNLLFISIEVSGVQQQLTSVPVQHVYTNQVQYVEGEDNNYTTSTIRSGTFPYTDTPLYTQTTAAPYYEGQPTSGTQASTPGTPLTVSVTAGTTAGGYMLGSGGSSSSSGSAAGNSQNYSHTARASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKAGSSLLRLMEDQQHLAMRQQPFSQKQRLKPVHKVEGMTNGTAAGAGQQQQQQQGSGHVDISTQVQQYQQFLDASRALPEFPEIDLQGKSLPEGIELEHIKSFQLLYREHCEAILDVMVNLQFTLVETLWKTFWRFSQSQAGDATHDESEKRLPKSCLVLLCKYEPVLRWSRDCDNSLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTNAMMNIPEEMVRIKVTSANAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKLTLQQQNSLEQWAAWLDGVVSQVLKPYQQSPAFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEVSTYTDPEMQIHSYNKEEEEEEEESDEEGQELSLPSDGAVLGEESLEPPAKLARTDQRVLFATGSADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2P8</accession>
    <name>A0A3P9C2P8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Secernin-2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2P8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016518"/>
    <dbReference type="Ensembl" id="ENSMZET00005017042.1">
        <property type="protein sequence ID" value="ENSMZEP00005016518.1"/>
        <property type="gene ID" value="ENSMZEG00005012384.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013474"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.10:FF:000001">
        <property type="entry name" value="Secernin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF16">
        <property type="entry name" value="SECERNIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="421" mass="46396" checksum="949AAF45FBB9B1CE" modified="2019-02-13" version="1">NQSSQPPMSCDCFVSLPPGSRDDHVIFGKNSDRPRDEVQEVVHYPAASHPPGSMLECTYIQIPQVEQTNAVVLSKPAWMWGAEMGASDKGVCIGNEAVWTREPVAPGEALLGMDLVRLGLERGDSARAALTVITSLLEEHGQGGQCREAPEPFSYHNTFLLVDRSEAWVLETAGRLWVAQKVSEGVKNISNQLTIGSEISTEHPDLQSVAKAQGWWDGEGEFNFSHVFSPENPPARMELAKQRYRGGTELLQQHDGSVTAEVMMSILRDKPSGICMDSGGFCTTGSMVSILPRDTALPCIHFFTATPDPSRSVFKPFIFSDCPTPVPRVVSPQFGPDDPARKQPRFQSQVDRRHDLYKAHQVALNTMETNPDEGLAVYNILRDLESQCLSEIAAMLSGEIPGEELGDLFFDCVDTEIKFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2Y3</accession>
    <name>A0A3P9C2Y3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C2Y3"/>
    <dbReference type="Ensembl" id="ENSMZET00005016763.1">
        <property type="protein sequence ID" value="ENSMZEP00005016246.1"/>
        <property type="gene ID" value="ENSMZEG00005012200.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183023"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000024">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052921">
        <property type="entry name" value="GPCR1_Superfamily_Member"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF871">
        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="44"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="332" mass="38561" checksum="B62F457B242584EC" modified="2019-02-13" version="1">MCPLIMDNQSNERSFILSGFNEIMNFTVPLFSVTLLYYCVILFFNISLVLLIVLDESLHEPMYILLSSFCINALYGTTGFYPKFLSDLLSSSHRISYEGCLLQGFIMYSFACCDLSILTVMAFDRYMAICRPLHYYSFMTKRRLSQLVCFSWLTPFCVFAINVLLTARLKLCGIKIQRALCLNWLIVQLACPEADTFPNNISAYVILVIYLSHWLFIIWTYIYIIKTCVRSREDRVKFTQTCVPHLTSVIINFTVLAFDSMYLLYMISGSTRLPQSLQNFITIEFLIIPPVMNPLIYGFKLTKIRNRILGLFYFKRTSKLRLSCSPNKNRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C485</accession>
    <name>A0A3P9C485_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-carbonic anhydrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C485"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017095"/>
    <dbReference type="Ensembl" id="ENSMZET00005017641.1">
        <property type="protein sequence ID" value="ENSMZEP00005017095.1"/>
        <property type="gene ID" value="ENSMZEG00005012837.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164039"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF200">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbonic anhydrase"/>
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    </dbReference>
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        <property type="entry name" value="ALPHA_CA_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="190" mass="21822" checksum="F0FEC19F8A91787F" modified="2019-02-13" version="1">MEVVTKIKLFFFFFYNQTHTCLYFIPLILFLVQMHIVSKKKDLTLDQALQAPDGLAVLGFFIEVKLGQTHPTSALTSKTNAWKKLTSYRSKIHKVTDDISIDDLLGDVNRHEYYRYSGSLTTPLCSEAVVWTIFKESINVDLNLMKMFPNQTGYFNVYRPTQPCHTRTILTTAGSYLSPCNNDGNKRIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4J4</accession>
    <name>A0A3P9C4J4_9CICH</name>
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        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4J4"/>
    <dbReference type="Ensembl" id="ENSMZET00005017499.1">
        <property type="protein sequence ID" value="ENSMZEP00005016959.1"/>
        <property type="gene ID" value="ENSMZEG00005012736.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161228"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051587">
        <property type="entry name" value="Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
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    <dbReference type="PANTHER" id="PTHR45813:SF2">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="89"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34425" checksum="5DF047F261989DC6" modified="2019-02-13" version="1">MESTLVFLLKSLTQLHLTQLSLPNTYFPLLTPRPRHFELQCVSWNYNQSKWTDEGCVWGGASKPDECTCNHLTSFAILMSRYPIKIPYMTEITYAGLSASVVSLVISLLIELIVWSKVVKTNTLHLRHTAHVNISLCLLVADCSFLASSQPKSISEIWCRIAALLKHFCYLAMFFWMLSLSTMLLHQAVFLFHKVGKKTYLRFSLILGYVCPFLIVFITFLTNNGGAQDAYFSLETCWLVYSGLLKGTIYTFILPVGIINGKFYLSTVTKYIYSSSVENLTMASPKTFANNGPHPFSRCEKGCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4V9</accession>
    <name>A0A3P9C4V9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4V9"/>
    <dbReference type="Ensembl" id="ENSMZET00005017683.1">
        <property type="protein sequence ID" value="ENSMZEP00005017137.1"/>
        <property type="gene ID" value="ENSMZEG00005012859.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156647"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1620.60:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000008">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
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        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
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    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
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    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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        <property type="entry name" value="Peptidase_M12B"/>
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        <property type="entry name" value="TSP1_rpt"/>
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    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
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        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
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        <property type="entry name" value="ADAMTS_CR_2"/>
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        <property type="entry name" value="Reprolysin"/>
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    </dbReference>
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        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
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        <property type="entry name" value="TSP1REPEAT"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TSP-1 type 1 repeat"/>
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    <keyword evidence="4 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
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    <keyword evidence="8 14 16" id="KW-0862">Zinc</keyword>
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            <begin position="44"/>
            <end position="248"/>
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        </location>
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        <location>
            <position position="47"/>
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        <ligand>
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            <label>2</label>
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        </location>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3P9C7T0_9CICH</name>
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            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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            <taxon>Haplochromini</taxon>
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        <scope>IDENTIFICATION</scope>
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</entry>
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    <name>A0A3P9C8F8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">procollagen galactosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.50</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5R)-5-hydroxy-L-lysyl-[collagen] + UDP-alpha-D-galactose = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12637"/>
            <dbReference type="Rhea" id="RHEA-COMP:12752"/>
            <dbReference type="Rhea" id="RHEA-COMP:12753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:133442"/>
            <dbReference type="ChEBI" id="CHEBI:133443"/>
            <dbReference type="EC" id="2.4.1.50"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.50" evidence="7"/>
    <dbReference type="RefSeq" id="XP_004559625.1">
        <property type="nucleotide sequence ID" value="XM_004559568.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C8F8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018558"/>
    <dbReference type="Ensembl" id="ENSMZET00005019158.1">
        <property type="protein sequence ID" value="ENSMZEP00005018558.1"/>
        <property type="gene ID" value="ENSMZEG00005013935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480600"/>
    <dbReference type="KEGG" id="mze:101480600"/>
    <dbReference type="CTD" id="565862"/>
    <dbReference type="GeneTree" id="ENSGT01030000234558"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050211">
        <property type="term" value="F:procollagen galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000048">
        <property type="entry name" value="Glycosyltransferase 25 family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF28">
        <property type="entry name" value="PROCOLLAGEN GALACTOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13704">
        <property type="entry name" value="Glyco_tranf_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018282581" description="procollagen galactosyltransferase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="11">
        <location>
            <begin position="329"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="610" mass="70944" checksum="BC02F95CBFD590AF" modified="2019-02-13" version="1">MPRLAGLNDALLLLLLSCCSPVRGYFAEERWNPESSLLAPRVLLALICRNSEHSLPYFLGTIERLNYPKDRMALWVATDHNEDNTTAILHDWLVKVQKLYHYVEWRPKEEPRNYEDEEGPKDWTDPRYEHVMKLRQAALESAREMWADYFMLADCDNLLTNSNVLRGLMKQNKTIIAPMLDSRAAYSNFWCGMTSQGYYKRTPAYIPLRKQIRKGCFAVPMVHSTFLIDLRKEASRQLAFHPPHPEYSWAFDDIIVFAYSAKMAEVQMFVCNKETYGYFPVPLRSHNTLQDEVDSFLHTVLEVNVRNAPVMPSKYISVPRKQPDKMGFDEVFMINLQRRTDRRERMLRALHEQEIACKVVNAVDGKAMNVSEIHALGIHMLPGYSDPYHGRPLTKGELGCFLSHYNIWKEIVERSLHTSLVIEDDLRFEVFFKRRLMNLMSEVDREGLDWDLIYIGRKRMQVAHPEKAVPNIHNLVEADYSYWTLGYMISLQGAQKLLKAEPLKRILPVDEFLPLMYNKHPVSDYMEQFETRDLLAFSAEPLLVYPTHYTGDPGYVSDTETSTVWDNEKIRTDWDRARSGKSHEQAEISTEAQNSDVLQSPLDSTARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9J6</accession>
    <name>A0A3P9C9J6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RELT TNF receptor</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RELT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004543906.2">
        <property type="nucleotide sequence ID" value="XM_004543849.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9J6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018948"/>
    <dbReference type="Ensembl" id="ENSMZET00005019545.1">
        <property type="protein sequence ID" value="ENSMZEP00005018938.1"/>
        <property type="gene ID" value="ENSMZEG00005014214.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005019555.1">
        <property type="protein sequence ID" value="ENSMZEP00005018948.1"/>
        <property type="gene ID" value="ENSMZEG00005014214.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101467437"/>
    <dbReference type="CTD" id="84957"/>
    <dbReference type="GeneTree" id="ENSGT00940000160350"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13419">
        <property type="entry name" value="TNFRSF19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022248">
        <property type="entry name" value="TNF_rcpt_RELT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022333">
        <property type="entry name" value="TNFR_19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034048">
        <property type="entry name" value="TNFRSF19L_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47397">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47397:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12606">
        <property type="entry name" value="RELT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01970">
        <property type="entry name" value="TNFACTORR19L"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044597149" evidence="9">
        <location>
            <begin position="24"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="10">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="434" mass="46335" checksum="909EFCAC39AAFE01" modified="2019-02-13" version="1">MRNHLCCSAIVLLALFGCGGTAAVQSRCGKGCACLQCPAGQEPSKACGQIQSPAEEVHCQVCPAGTFSDALDSEVCRPHTSCKILGRKLASSGNGTSDAVCGHCLTGFHSSAAGQVSTQSPCVKKGLHVRVVRNVGNGQSGGAGGPANSTVVRSAEEKTAEYAVFALVPVFCVMGLLGILICNILKKKGYRCTGEKEGGDEETATPQKEGNTCPYISDDLNEDTISVLVRLITEKKENAAALEELLLEYETKEMAMSKGSSIKFPMLSPLSQFRSLPRLCPHQSHHHTISGLSGLAPRHGYRCTRCAQKKWPPVLIPPLDSLKDPLKPPQSLILPSLDTSSDQQKSPLLGGECMNTHHTQAAVPKTVQEKMEGSEVKEKKEGELTVLSVGRFQVAQIPEQKPCTVETKRASQEQRNSFFGGKSFSLSSSSGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9X9</accession>
    <name>A0A3P9C9X9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA thioesterase 11</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9X9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018897"/>
    <dbReference type="Ensembl" id="ENSMZET00005019503.1">
        <property type="protein sequence ID" value="ENSMZEP00005018897.1"/>
        <property type="gene ID" value="ENSMZEG00005014172.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156460"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="5">
        <location>
            <begin position="245"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="440" mass="49485" checksum="2791B3BC70756FA1" modified="2019-02-13" version="1">AAVLSPFVVAIYMIIEVFAYNKDLFYIKYLCLAFFSFHLDLTVTLKPIVPVTQKEQVEYSVAAERRRVRMVHDDIIKDLLSNDSVGPSAVAAERTRVESVELVLPPHANHQVTRGRSWPIVSVLSACSRLSQAHPTLRAIDMFTFRGPSQVGDRLLLKAIVNNAFRNSMEVGVRAEAYHEEGPNRHINSAFMTFEVLDDGGKPRTLPRIRPEPLMSLWFLCLCFQVYLSFNNVSALKMLAARSSWCLSCEKDQLYTLEQKSMLSFKIECEVDVPAHRAFDLLAELSNRPSWDSHYKKCELIQLVDNDDFIYRVVTPSVRHGAMGSPTAANQAKGILQDFILLASKRKPCGSGDPYVIALRSVSLPTHPPTEGYNRGEVLCAGFTILETKDNKSLVRKAISYFNQASPEVLPYISTDIAGLSSSFYHTFCSCSQYLTRNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAV5</accession>
    <name>A0A3P9CAV5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Receptor tyrosine kinase-like orphan receptor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAV5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019041"/>
    <dbReference type="Ensembl" id="ENSMZET00005019654.1">
        <property type="protein sequence ID" value="ENSMZEP00005019041.1"/>
        <property type="gene ID" value="ENSMZEG00005014280.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153947"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05090">
        <property type="entry name" value="PTKc_Ror1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF134">
        <property type="entry name" value="INACTIVE TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
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    </dbReference>
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        <property type="entry name" value="KRINGLE"/>
    </dbReference>
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        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0420">Kringle</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="11">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="12">
        <location>
            <begin position="149"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="299"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="641" mass="71768" checksum="32DD836B666D18AC" modified="2025-10-08" version="2">MFTQIATALSFPLNGFPEDGFCQPYRGIACARFIGNRSIFVDSLQMQGEIETQITAAFTMIGTSNHLSDRCSQFAIPSLCHFAFPTCDRSSGSDKPRDLCKDECEILENDLCKTEYIIARSNPIILKRLKLPNCDDLATSDKPINKNHKCYNNSGVDYRGTVSITKSGRQCQPWNSQYPHSHNYQAVRYPELNGGHSYCRNPGNKHEPPWCFTLDEGVRMELCDIPLCGETLESGIEILYILVPSVVIPLAIALLFFFICVCRNNQKSSRPPVTRQPKPVRGQNVEMSIKAKELPLSAVRFMEELGECTLGKIYKGHLYLPGMDQAQLVAIKTLKDISNAQQWADFQQEAAVLTELQHPNLVCLVGVVTQEQPVCMLFEFLPQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHMAIQVAAGMEYLASHFCVHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYCLQPKIVLPIRWMPPEAVASGKFTTDSDIWSFGVVLWEVFSYGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRFYGLMTECWQEGPARRPRFKDIHARLRAWEGLSSHASSSTPSGGGGNATTQTTSLSASPVSNLSNPRYAAALCFVLTLTYHNLIGSNFCRNEVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBW9</accession>
    <name>A0A3P9CBW9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zgc:194202</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBW9"/>
    <dbReference type="Ensembl" id="ENSMZET00005020241.1">
        <property type="protein sequence ID" value="ENSMZEP00005019612.1"/>
        <property type="gene ID" value="ENSMZEG00005014721.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182966"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004974">
        <property type="term" value="F:leukotriene receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000109">
        <property type="entry name" value="Leukotriene B4 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF946">
        <property type="entry name" value="LEUKOTRIENE B4 RECEPTOR 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="94"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="397" mass="44418" checksum="3742AF4326829C85" modified="2019-02-13" version="1">MFLSKLFRSSKGLYVCVTLLVAMAQPLSVFQSLHLWRDPLTYQVQVCSMPQVNSTVATYNISSSPGYSTGTVWYSTNLVPAVVLSICFLLGFPGNIAVIILKPNWENMSSLSQSLMLSLAVSDLLCLGTLPLWIYSFLYSWTFSLVPCKLITYFVYGSVYASLLTVTVLSVQRYLQVIHLQRSLNQVRARKLLLPLWLSAMTLSTPALLAQQLVEVYQQRIYCRPQYSSEGQRMAILLTEALVGFVSLSVIVFSYISLYRKVNRAAFFNNPQTTKLITSIIVTFVILWVPYFVIDVLGVAAISLKNEALLTFCEDSWNTVGALTFVNGAVNPLLYAFTSDRLSTMWQKIAENLIQKFRIAQTLPELEVPGIGQQDGDFGGLALQHCPATKRPRHKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCD8</accession>
    <name>A0A3P9CCD8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TAR DNA-binding protein 43</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
    <dbReference type="RefSeq" id="XP_012773940.1">
        <property type="nucleotide sequence ID" value="XM_012918486.2"/>
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        <property type="protein sequence ID" value="ENSMZEP00005019965.1"/>
        <property type="gene ID" value="ENSMZEG00005014992.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154343"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:axon extension"/>
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        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:neuromuscular junction development"/>
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        <property type="term" value="P:skeletal muscle tissue development"/>
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        <property type="entry name" value="NTD_TDP-43"/>
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        <property type="entry name" value="RRM2_TDP43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAR DNA-binding protein 43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAR DNA-binding protein 43"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049124">
        <property type="entry name" value="TDP-43_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041105">
        <property type="entry name" value="TDP-43_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF9">
        <property type="entry name" value="TAR DNA-BINDING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20910">
        <property type="entry name" value="TDP-43_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18694">
        <property type="entry name" value="TDP-43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="105"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="192"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018889"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="402" mass="43585" checksum="D66FC804B87BD78F" modified="2019-02-13" version="1">MAEVYIRVAEEENEEPMEIPSEDDGTVLLSTVAAQFPGACGLRFRSPVSQCMRGVRLVEGVLHAPENGWGNVVYVVNYPKDNKRKMDEIDASSAVKMKRGDMKTSDLIVLGLPWKTTEQDLKDYFSTFGEVIMVQVKRDAKTGNSKGFGFVRFTEYEAQEKVISQRHMIDGRWCDCKLPNSKQGPDEPLRSRKVFVGRCTEDMTTDDLRQFFMQYGEVTDVFIPKPFRAFAFVTFADDQVAQSLCGEDLIIKGVSVHISNAEPKHGNRQFDRTARFGNGFGAQAFGSSRSGLGSSTNSSLANFGSFSLNPAMMAAAQAALQSSWGMMGMLASQQQTSTSGSTSSGTSSSRDQSQSFSTGNSNYGTSSASLGWGTGSNSTTSGSGFSSGFGSSMESKSSGWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCR7</accession>
    <name>A0A3P9CCR7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adrenomedullin a</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adrenomedullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004543216.1">
        <property type="nucleotide sequence ID" value="XM_004543159.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CCR7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019804"/>
    <dbReference type="Ensembl" id="ENSMZET00005020440.1">
        <property type="protein sequence ID" value="ENSMZEP00005019804.1"/>
        <property type="gene ID" value="ENSMZEG00005014863.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487032"/>
    <dbReference type="KEGG" id="mze:101487032"/>
    <dbReference type="CTD" id="556502"/>
    <dbReference type="GeneTree" id="ENSGT00940000154380"/>
    <dbReference type="OrthoDB" id="8771893at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031700">
        <property type="term" value="F:adrenomedullin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990410">
        <property type="term" value="P:adrenomedullin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010460">
        <property type="term" value="P:positive regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003073">
        <property type="term" value="P:regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051665">
        <property type="entry name" value="Adrenomedullin-reg_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021116">
        <property type="entry name" value="Calcitonin/adrenomedullin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23414">
        <property type="entry name" value="ADRENOMEDULLIN, ADM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23414:SF3">
        <property type="entry name" value="PRO-ADRENOMEDULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00214">
        <property type="entry name" value="Calc_CGRP_IAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018231488" evidence="7">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR621116-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="164" mass="18649" checksum="FF6E754428770294" modified="2019-02-13" version="1">MKLIFQSFICCCLLATVAHCVELEVNPELKKRLSIWLGSRLRRDVDTISVEKRAEAEHLVRPEDIRDALLPHSSTDIHVRTKRSSGCSLGTCTVHDLADRLHQMGKLRGGNAPAHKISAHGYGRRRRSLPSYRVSLRLEKGRLRPVWSTVDSQVHKLEALLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFB7</accession>
    <name>A0A3P9CFB7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Si:dkeyp-67f1.2</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CFB7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020983"/>
    <dbReference type="Ensembl" id="ENSMZET00005021672.1">
        <property type="protein sequence ID" value="ENSMZEP00005020983.1"/>
        <property type="gene ID" value="ENSMZEG00005015745.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183004"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13940">
        <property type="entry name" value="ILEI_FAM3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039220">
        <property type="entry name" value="FAM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039475">
        <property type="entry name" value="ILEI_FAM3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14592">
        <property type="entry name" value="UNCHARACTERIZED FAM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="ILEI/PANDER" evidence="8">
        <location>
            <begin position="91"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="216" mass="23471" checksum="93CDB7465FA697F4" modified="2019-02-13" version="1">LLLTAVLPLAAVIIVLLITWGISINSSVAQERERNTLAPPTSVPKCSLSRVCPPNHIALRIRSGAADIVGPTVCFDGKIIMSHALNNVGPGLNIAVINGETGVVEKSVCLNMKTGDPKDILAHLKKIKRGMIVLVASFDDVTQKMTNEMREIFSEMGSTLIRSVKRRDSWVFAGRAGTKIKSLFEKQAVNDEKNNIYGGWPEMVEVGGCFPRVFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFI1</accession>
    <name>A0A3P9CFI1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial tRNA-specific 2-thiouridylase 1</fullName>
            <ecNumber evidence="4">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004553982.1">
        <property type="nucleotide sequence ID" value="XM_004553925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CFI1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021048"/>
    <dbReference type="Ensembl" id="ENSMZET00005021740.1">
        <property type="protein sequence ID" value="ENSMZEP00005021048.1"/>
        <property type="gene ID" value="ENSMZEG00005015797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471286"/>
    <dbReference type="KEGG" id="mze:101471286"/>
    <dbReference type="CTD" id="55687"/>
    <dbReference type="GeneTree" id="ENSGT00390000014323"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061708">
        <property type="term" value="F:tRNA-5-taurinomethyluridine 2-sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000057">
        <property type="entry name" value="Mitochondrial tRNA-specific 2-thiouridylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000104">
        <property type="entry name" value="Mitochondrial tRNA-specific 2-thiouridylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
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        <property type="entry name" value="Translation factors"/>
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    </dbReference>
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        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF20258">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="16">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="15">
        <location>
            <begin position="303"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018888"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="416" mass="47276" checksum="B1276C1FAE9F5822" modified="2019-02-13" version="1">MALIKHVVCAMSGGVDSSVAALLLKRRGYNVTGVFMKNWDSLDEKGVCTTEKDCEDAYRVCQSLDVPFHQVSYVKEYWHEVFSNLLKEYERGRTPNPDILCNKHIKFNHFHKYAIDTLGADAMATGHYARTSQEDDEVFEQAHTAPPTTLFRDRFEIRNPVKLYKGADLLKDQTFFLSQIPQQALRQTMFPLAGLTKEFVKKMAAEAGFHHVLKKKESMGICFIGERNFENFILEYLDPKPGNFVSIEDGTVMGTHKGWFTLTLGQRARIGGQRDAWFVVDKDIVTGDVFVAPTTNHPALFRDTVRTERFHWVTEDPPPELARTQMMDCHFRFIHQMPLVPCTVTLNMDGSVWILLSQPVRALTPGQFAVLYKGDECLGSGKITQLGPSEFTLQKGRERIVAAFQRKEQSTPEPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CIY5</accession>
    <name>A0A3P9CIY5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Notch ligand N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CIY5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022255"/>
    <dbReference type="Ensembl" id="ENSMZET00005022998.1">
        <property type="protein sequence ID" value="ENSMZEP00005022255.1"/>
        <property type="gene ID" value="ENSMZEG00005016693.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166445"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
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        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Notch ligand N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="180" mass="19439" checksum="FC63C7456A0E524E" modified="2019-02-13" version="1">MESSRVHGITRKNLRSRGEKLNGNPDMRAGRHQGHFHLPRTVIFFVALTVQTQAVCAVGMFELQIRHFQNPHGRLQTGECCDLQASGAQHCSARDQCDTFFQACLKEYQARVAPTGACTFGTGSTGVLGGNSQLFHHRGHDRGGGGEDGSNGHIVIPFQYAWPVSTGAVMVSSMVTKGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CIY6</accession>
    <name>A0A3P9CIY6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 238a</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CIY6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022117"/>
    <dbReference type="Ensembl" id="ENSMZET00005022858.1">
        <property type="protein sequence ID" value="ENSMZEP00005022117.1"/>
        <property type="gene ID" value="ENSMZEG00005016591.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162720"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029365">
        <property type="entry name" value="TMEM238"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28613">
        <property type="entry name" value="SI:CH211-232M10.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28613:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15125">
        <property type="entry name" value="TMEM238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="109" mass="11705" checksum="6DF28389AACA43FF" modified="2019-02-13" version="1">MAPKYDGLSHCKLALVFAVLMDLLGVISLLLGVFAPLEIKGQDFGDLLVYSGALLVLFSLAGWVMWYSGNIEGLTSKIELGGVVGGAVDRLARNLSRRIRLPRTQSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CK52</accession>
    <name>A0A3P9CK52_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone H3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CK52"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012671"/>
    <dbReference type="Ensembl" id="ENSMZET00005013115.1">
        <property type="protein sequence ID" value="ENSMZEP00005012671.1"/>
        <property type="gene ID" value="ENSMZEG00005008058.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005015991.1">
        <property type="protein sequence ID" value="ENSMZEP00005015493.1"/>
        <property type="gene ID" value="ENSMZEG00005010575.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005023276.1">
        <property type="protein sequence ID" value="ENSMZEP00005022527.1"/>
        <property type="gene ID" value="ENSMZEG00005016180.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286903"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000047">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="4">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="90" mass="10279" checksum="D3C386B516CCA6D3" modified="2019-02-13" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQRFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKJ8</accession>
    <name>A0A3P9CKJ8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclosome subunit 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the APC8/CDC23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564047.1">
        <property type="nucleotide sequence ID" value="XM_004563990.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CKJ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022848"/>
    <dbReference type="Ensembl" id="ENSMZET00005023600.1">
        <property type="protein sequence ID" value="ENSMZEP00005022848.1"/>
        <property type="gene ID" value="ENSMZEG00005017099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465222"/>
    <dbReference type="KEGG" id="mze:101465222"/>
    <dbReference type="CTD" id="8697"/>
    <dbReference type="GeneTree" id="ENSGT00950000182950"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000093">
        <property type="entry name" value="cell division cycle protein 23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="11">
        <location>
            <begin position="15"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="575" mass="66482" checksum="10CD38ACACBEFC52" modified="2019-02-13" version="1">MKMAALCSEFGDLLQIKKQLISVISLCKERGLLHSAKWASELAFALDPLPKDELPPTSPLTEEDAQDLDALTLAKSYFDLKEYDRAAYFLKGCRSQKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVRNEALRELRVELSKKHTAGELDGFTLYLYGVVLRKLDLPKEAVDVFVEGIHALPLHWGAWLELSNLVTNIEMLKSLSLPDCWIKDFFMAHMYTELQMIKEALQKYQNLIEAGFSKSTYIISQIAVAYHNIRDIDQALALFNELREQDPYRIDNMDTFSNLLYVKSMKPELSYLAHNLVEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRCLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRKAHQLRPNDSRMLVALGESYEKLSQQAEAKKCYWRAYSVGDVEKMALLKLAKLHEQLNESDDAAQCYMLYIQDIFSCGEQLEHAEVSTALRYLGQYYFKNKLYDEASLCAQRCCDYNDAREEGKALLRQISQVRDQIETPSADLFAPLSNNNTPVRRVSPLNLISFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLQ8</accession>
    <name>A0A3P9CLQ8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin family member 25</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLQ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023265"/>
    <dbReference type="Ensembl" id="ENSMZET00005024026.1">
        <property type="protein sequence ID" value="ENSMZEP00005023265.1"/>
        <property type="gene ID" value="ENSMZEG00005017410.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162166"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF63">
        <property type="entry name" value="KINESIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="170"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="261"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="591" mass="65510" checksum="8091847BC6BB9DF2" modified="2019-02-13" version="1">MPLFINRDQIFAHQVHLLEHKLRFQSKEERILELETENALLHLRLAECSGRQRRDHDEGTKAVNDHQLQSSARKITQSALIKLLSGVQKHDLSELFAVYVSFATELEEQSKQLLEKVEQANSSLNGHSEDGFQLQVRVAALEHSLEEERENCRAERRKRKELHNTLLRGNIRVHCRVRPVLPFDQIQSSTSGSSASSEEVIQAVSDDTVMVNCMKAGMLVQNKMFEFEVHGPEDSQEAVFEEVKSLLTSLLDYNVCIMAYGQTGSGKTHTMMGSQFLDELSGTQQEAQQGIIPKAAAELFLISEKPAESHTVEVSVMEVYNNEVFDLLARDEHSNAAGQRRDVITSSSGASQVPSLTSPVSNASEVMQIISSVLKLRAHCPTLVHADSSRSHLIVTLTVSSKSPNAVALARRLQSAKMDMRRSTQKEWWSPRCRRANLAAHHPADETSASPASSPCSTPSLSPCPSPRHSITQTPFRTKLQLVDLAGSECAMSGVSGAALWESSCINRSLSALSDVLGALAEHRPHIPYRNSKLTHLLQDAIGDAKLLVMLCVSPTQRFITESLQSLGFGTRARQVQKEPPRRKNNSLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMQ5</accession>
    <name>A0A3P9CMQ5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMQ5"/>
    <dbReference type="Ensembl" id="ENSMZET00005024121.1">
        <property type="protein sequence ID" value="ENSMZEP00005023357.1"/>
        <property type="gene ID" value="ENSMZEG00005017482.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177270"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017943571" evidence="2">
        <location>
            <begin position="16"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="334" mass="37120" checksum="FB276A30779F033C" modified="2019-02-13" version="1">MVCLCFLVAVSTVSSSRLCVILPFCRPYPFLWPNHLNNQPLNSLLSTPRLPRRLMPRQLEGPRSPSGLMPRQLEGPRSPSGLMPRPLEGPRSPSGLMPRPLEGPRSPSGLMPRPLEGPRSPSGHLSPLEGPRSPFSLTPRQLEGPRGPFSLLSPLEGPRGPFSLLSPLEGPRGPPSSLTPRQLEGPRSPSSLTPRQLEGPRSPSSLTPRQLEGPRSPSSLTPRQLEGPRSPFSLTPRQLEGPRSPFSLTPRQLQGPRSPFSLTPRQLEGLRSPSGHLLLHHLWLQRHLLRLPCRRLQDHHLLRYCLLLLRLSLTPRLVLPHLSLRTHTNSFHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNW6</accession>
    <name>A0A3P9CNW6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Early endosome antigen 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005024035"/>
    <dbReference type="Ensembl" id="ENSMZET00005024824.1">
        <property type="protein sequence ID" value="ENSMZEP00005024035.1"/>
        <property type="gene ID" value="ENSMZEG00005017978.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156910"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15730">
        <property type="entry name" value="FYVE_EEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000180">
        <property type="entry name" value="Early endosome antigen 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69979">
        <property type="entry name" value="Eea1 homodimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="1336"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1091"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1395" mass="158977" checksum="5CF04B6396CCF394" modified="2019-02-13" version="1">KVLFSVHQTPGKGGSQNAESEQPSTDLNHDQTSEGFICPQCMKSHNSAEELFKHYELFHDTGDLPAHVAPTREDLTMLRQEVQDLHTSLKEERWFSGELKKELDKVQGHLNRSSVANMSCCFSVLERKLNEAETEKFNIKQMKDLFEQKAAQLATEIVDLKSRYDEEKSLREAADQRLAKLNEQLQEAKEENERLQTELLQRPGVEDVEVLQKELVQVQTLMDNMTREREEESERLKNHYEQLQANYTTSEMTISQLKAELEKGPQEAAVYTQQIHELQSNLNNLQQQSQSLSEKLARKEKEYQDLEEHLGAEKASKKEVQESLRERELEVQELQARATGAEASLHKAQMEVSERAEEVAKLKSEITELEVKHAELKVERKQLEQQREEKESQGAQQQTEISQLHAKLLEAERQLGEVQGRLKEQRQLSGEKLKDREQQAADLQLKLSRAEEQLKESASKSTDLQHQLEKAKQQHQELQALQQNTNGKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKDTVSQLEAEREDLCAKIQAGEGETAVLNQLKEKNHALQEQVTQLTDKLKNQSESNKQAQDNLHKQVQEQKTLLRSAQDRAHTLETSVTELTTQLTESKEKVAQLDTQLKAKTELLLSAEAAKAAQKANLENSLESAQHALQDKQQELNKVQKNLEDHGQRLKERQEQCTQLESSLKECKDKLLASEQRIEQLEGLGKKLESQVGEMQAARDQAQQELQQLQKESSEVKKKAKELQRSLETEKAGATSLQEELKKKAGTLSDVQQKLAQSEQGIATLKANLEKVTQEGKSQHAELDKKAQSLAAELQKAQEGKKAQQKELAATQESLGKANKALKESQSQLDTERKNHKSAIEEKVGLVNLQQELLKNNESIRKAMKESKEQLEQMRESEKQLKVQLTSLEQQHTKTRETLREKENELEKLRTQLKMTQGSLEEEIKKLNGQVTELKEAGVKKAQEENKLRAQVSGLGQELTSEKSRTAELQKALEQSKENISKLQSDVYGKDSEVSALRQDLKASEQKLSVAQEELAANQTHQSGLESQIQDLKSARSSLEQELAKRDEKLQQKEQTLKELQKQKGQVKEELDKEKSNVEELNKAKSVLEKNNSRLTSELKTLTEKSEKELGELQEAKQLLIQQKLELQAQVEAAQGALKQEQKEHQTTKDGRSEREEQLLAQIRDAQDQLAAEKKRWQEQVKRGEEAEAKMGLQVTALNENVATLKREWQGSQRRVGELEKQTDELRGEIAVLEATVQNNQDERRALLERCVKGEGEIEKLQAKVVELRRKLDDTTAAMQELGRENQSLQIKQSQSLTRKWAEDHEVQNCMACGKGFTVTVRKHHCRHCGNIFCAECSSRNALTPSSKKPVRVCETCFEELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQW3</accession>
    <name>A0A3P9CQW3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized LOC101476997</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552057.2">
        <property type="nucleotide sequence ID" value="XM_004552000.3"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005024432"/>
    <dbReference type="Ensembl" id="ENSMZET00005025233.1">
        <property type="protein sequence ID" value="ENSMZEP00005024432.1"/>
        <property type="gene ID" value="ENSMZEG00005018265.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101476997"/>
    <dbReference type="GeneTree" id="ENSGT00940000157762"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ESCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="12">
        <location>
            <begin position="2752"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="13">
        <location>
            <begin position="2910"/>
            <end position="2978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="966"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1423"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1499"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1634"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1727"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1936"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2072"/>
            <end position="2133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2179"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2318"/>
            <end position="2729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="73"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="167"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="238"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="279"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="520"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="978"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1200"/>
            <end position="1215"/>
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        <location>
            <begin position="1235"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1256"/>
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            <begin position="2353"/>
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            <begin position="2690"/>
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        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2994" mass="324767" checksum="F2E738EF7FB1E002" modified="2019-02-13" version="1">MPASKRGSAPPDSQSKIRKLDEDGEAAPSKTVPAANNQSHNNTGNMKEKTAAPRTKKKLCASPEGGHKLAKSPKQSSPLKDSSKTSPDPPVKKAKLQKATSASCGEAPSPKANSKTSLKRTASMDSDELSSDGSKADFFRERDDEDKARCIRKYSNRVKAKRKTEESPSVSEDTSQGLSSPPKDPIQMDHNYGIFTDSPCLETTDEANENIKKESAESFTEQERPQISAIAPQEVSKETTVSVTDTKFESSANESKHKELQNVESQKGVDNETPASSRDISDHLISEAEKKDEEEFVQKDLDDKTLPSSMETLSLAAGEVDPKCKDEKQSCMSESLRTETKTNETTQFVSGENKLSVQCTAKGSTESATISSALSNEFNSASEQLLVESGIPENETQADIVRALATSDGESNLVDTQDDVPIAVTDTCVDVETIVIRSEEDLQESDGKEADFQLTQVVSCPGGLVERQLSHDCVMTDSRTEILTPDCEAVQREVISECFTVPDGQIAPSVDLQNQENHRLFDNTAEKPDDGVKEDSESTEGDTSMICVTAASSQINMDILTAAASEEISVVEIQRQEKQDAPEPIADISTNFHEDHVGENCRIMEDKHSVSFGHSSGAETETKIETQNIVISEVSNTEVQILETQEICNATTAESTEVHVMDDKSDNIKTFECADGSESQEKIQTQSLSALEVSNPAAKVEVQNQERPDGEATSDKVQEDLRTANYESSKEAECVAAVEKRMETPDDVEAETTSVEICNIEQTHQMSQVDSESTTAESHMDQIVENVQSVEMQTKLTMEVSYPSASVEIQRSQTEVELQTTLGTSSDIAPGAGIQSHKNHEINECNTDDIPKEITEDSMIENFQTVQNEDKCVTLTPEISEAAHSVEVHSEKSPEVVEMESAATSEEVSNIPAAQIQNQENQDVGAHITDTVYTESVTVPKNENKTEDQPKSPIEFTGHASMMELQSEKSQNEVEMETATTSEEVSDTSAVETETQTSQDVCEDGAGMQIDSVTVAENENKKEEKAKTTPEISEVVPSVEAQSEKIQSEVGMESAAPSEEVSKIPAVEIQSQISKVITEYSTDVHTQSVTSTPDSPKESTSVEIQLVQSQNEVDAEQKTPEEVASIPALEIKSQDVIEHNTDILMQPISVSENENEMEKQAPSISEAEISVEVQCGKSLSEVEMETTTTSEELCIPPAAETHKQKSQDVSEHTEDSYTQPVAVPEREIEMEEQAKSTQEISVEIQSENSLNEVDMESAAASEEISSTPAAEIQNQTSKDVCERSTDVHTEPVTGAENENKKQDTLIADISISAHSQEIQEAAEPTGDISKEVHKGLRNPTNHPNKAHCVTAAESQVEMEATEAPKETSEPTNNPSQKGQEVSELTINTTVEKDFINALSEEEDDKVKADCVIAAESQRKVEVQTTETLEEVSDLKNVPETQSKKDRETTELKTDTEAGKDFINTEEKDDKVDAECVSVTESPGEMEIQTVEAPEKITYLTNKQNQRGQEVSELTTDTEVEKDLTGTECEEKDVEVNEESLSAVENQGEMEVQTTESGEERSDVEVHNDGNQEVGDVQEDLMSARCETRNEEEPASECVNILETTAEGSPYLTKQQSNVTEEINEDTTALLEIQKQRGPRADVDITSESTEREASVLEEETGSQMFNEVKADGSVGNIEGGGADSSEVMLFVCGQTDNNNVVIQPSEEQIEMVNQSAVGPHENQIVYEPISSPESNDDRDVSAAAAEKHDAVSILDIQCTEAQQMETNFSSNEDNREIGGMQLVNEVAKEEICVPDSQAGVEMEVQAQPAQLEQINATVDVKEVAPISSGSDMSVADGGSGDAAEVKSEMTVKSEGNGISECIRATEFSEQVQHDAGVQEAAGVTVTTTTPPTTTTSSTEFEVPGGASEEYVILEPVPQSEIHFDIVTQAATESGLAASLSEQVNPESESMEEKAESERTLNGSEQTVFTEAAASSGEVAEQETNISPVEEDVQVIQPSDHQSSHMVDMNTSHDSEPQSLIEDINVVVIEDAQDNLDIQEVQILEDIEIGHEIIVVEEENDEDSDIAVVEKPQETAEAGLPEEKVNEKYICNTSGPDMKQNSTAEKTEEEKKAQEPEKPKKQEMNTQARTKARLAALAEQKAAAAKRSANRQQLNLLALCQEIAEDIATDSMLLKRIEEEKQAAAAAAKSEASKKERPPVNTQDANTVNVATPAGPEGCAPPSVTPAPEAPPAQPSTADSAETQPSAEPPKRRFFITQISVPLKVHEKKKLTRYQRLRQVELQREKMSWARVKKLKSDQANQMFSDMDWQAPFSAASLFPVSPVTTPPPQPAASPATSQLSPSASSKPATPKAEAPKNEPKAELAKTEPSKTEPTKTEPTKAETSKKQPTITETPKTEPPKTETGKPEASKMEPPSTENRRTTRQSKAQTTKAAATPEPAPKVTRSGTKRTLPAIPPPMPNGLNAQKLKMEVEYKPYRPRPKYSPDDFELDDDPLPAKPKPPGLQSNPSAQPKPTLLSKPTLTAQLANQAKLKAQTKPAGQISGQSKPSVAAPAQLKPAQLNPAVAPATQSKATAATAASSKLASSANAPLKSPVPTATQSKVVSAPAQSKPAASVSPQLKTAGADANLTQLKPSASPAARPAVAATSGMKPAASKAGAISVPQRPTDPACKENDKCKNAAHPLSSAPPEESAKVSDKLTESKAESLKEAEQTPGKPCQDKAVKPQDGGAPLSEACLQKEVKKLKEADKDGTQTVIDAGQKHFGAVACSVCGMLYSAANPEDESQHLLFHNQFISAVKYVGWKKERILSEFPDGKIILVLPDDPKYALKKVEEIREMVDNDLGFQQVETKCPSKTKTFLFISNDKKVAGCLIAEHIQEGYRVIEEPMPEGSEGEKLMFERQRAWCCSTTPEPAICGISRIWVVSVMRRQGIASRMLECLRNNFIYGSYLSKDEIAFSDPTPDGKLFATHYFGTSQFLVYNFVSGTRSHQPKTQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CRF6</accession>
    <name>A0A3P9CRF6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calcium binding protein 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">trans-Golgi network membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CRF6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024622"/>
    <dbReference type="Ensembl" id="ENSMZET00005025428.1">
        <property type="protein sequence ID" value="ENSMZEP00005024622.1"/>
        <property type="gene ID" value="ENSMZEG00005018403.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159368"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000115">
        <property type="entry name" value="Calcium-binding protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051111">
        <property type="entry name" value="Ca-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311:SF2">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="205" mass="23454" checksum="5F35BBAD6F3546B8" modified="2019-02-13" version="1">MPVRAVTTRFMYKGLCTIPDVLTYRTPVNLPEDEVEEIREAFKVFDRDGNGFISKQELGMAMRSLGYMPNEVELEVIIQRLDMDGDGQVGFEEFVTLLGPKLSAAGMPDKFNGADFDSVFWKCDMQKLTVDELKRLLYDTFRDHLTMKDIENIIMTEENHLNSPDPTQQEKHTCVRKSLICAFAIAFIISVMLIAANQMLRRGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSS3</accession>
    <name>A0A3P9CSS3_9CICH</name>
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        <submittedName>
            <fullName evidence="8">LON peptidase N-terminal domain and ring finger 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004569039.1">
        <property type="nucleotide sequence ID" value="XM_004568982.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSS3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025410"/>
    <dbReference type="Ensembl" id="ENSMZET00005026233.1">
        <property type="protein sequence ID" value="ENSMZEP00005025410.1"/>
        <property type="gene ID" value="ENSMZEG00005018961.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483157"/>
    <dbReference type="KEGG" id="mze:101483157"/>
    <dbReference type="GeneTree" id="ENSGT00440000033329"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16513">
        <property type="entry name" value="RING-HC_LONFs_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF5">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="485"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="564"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="778" mass="86121" checksum="3896455EB132F7C4" modified="2019-02-13" version="1">METGLRSHQGEAFVHPLSNPGAAGICPEMLEVAEEASRAGDFNLAVEIYSSQLADLQHPDRGLCLRKADSLSCAGRISEALDSYCTAASLGKLRPEELQLLVETIARTLREKELGIHATVNGSNKSSSGEDGFQNSGECEDDEALDLFSCHLCKCLLHEPTTVECGHTFCKRCTDDDSVTNCVHCKQNLSRKGLPNGRRINVVLSGLLDKLFATESKARKLWIEGEDSWKKQNLLEALEKYNGAVDLVPSSGRLLHQRAELHLEMQNFSQAVQDASSLCRLKTLWTEAHYLKATALSKAGRKDEALQEYFLCVALKPDWAKVKLEAQKVLGELFSSVFENEDLPTPLHPLQGGLATRLIKPPALLSSLRPLPQKPGSSSSQDSEFTVTKSPPVDDSSSRLCALSAGKSDPSPGEGSTKSLADVLAALPAPPGGLKRKHKSDELSATFSPPSKLLRADEGEIRQATAACGGRSVPAELLDSGDLECSLCMRLFYEPVATPCGHTFCLKCLERCLDHNPNCPLCKENLSEYLASRGYNKTLLMEEVLQRYLGDELAERKKIHEEEMKELSNLNQEVPIFVCTMAFPTIPCPLHVFEPRYRLMIRRSVETGTKQFGMCIADELKGFADYGCMLQVRDVKFFPDGRSVVDTIGVSRFKVLSHGQRDGYNTAKIEYLEDKKVEGEELTELLKLHDSVYDQANGWFTSLKDNMKSQIHSHFGHLPSKDPDPQASPSGPAWSWWLLAVLPLENRAQLTILAMTSLKDRLIAIRRVLIFVTRKRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUF9</accession>
    <name>A0A3P9CUF9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUF9"/>
    <dbReference type="Ensembl" id="ENSMZET00005026527.1">
        <property type="protein sequence ID" value="ENSMZEP00005025694.1"/>
        <property type="gene ID" value="ENSMZEG00005019175.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183016"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF26">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="228" mass="26449" checksum="26BC8186F37E9F5D" modified="2019-02-13" version="1">MSVKISTWNVKGSNNVVKKKSILNSLKKDLTHIAFLQETHLTDDEHRKYCREWVGQIFFSSYTNKRGVITLIHKNLPFNVTATHKDNEGRYILVKGMLHGETVLLGNIYAPNTQDGEFYTVLFSQLVDMDCANIILAGDFNCVLCPKMDKFPPQSILTKNSKALWQIINELDLIEVWRHYNPLSKEYTFHSNPHLSASRIDYIFMSKCISHLVLSMMYKSYDFCLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CXZ1</accession>
    <name>A0A3P9CXZ1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Probably forms covalent oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005026969"/>
    <dbReference type="Ensembl" id="ENSMZET00005027834.1">
        <property type="protein sequence ID" value="ENSMZEP00005026969.1"/>
        <property type="gene ID" value="ENSMZEG00005020112.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156850"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000128">
        <property type="entry name" value="enteropeptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025615">
        <property type="entry name" value="TILa_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF374">
        <property type="entry name" value="ZONADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12714">
        <property type="entry name" value="TILa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018034136" description="Zonadhesin" evidence="10">
        <location>
            <begin position="26"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="416"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="11">
        <location>
            <begin position="702"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="11">
        <location>
            <begin position="879"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="1236"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1285"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1095"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1293"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1437" mass="158837" checksum="E2AD76038B8B7C89" modified="2019-02-13" version="1">MLGGIRTDLVVTVAVLFLTQTGTQCRGPNGTSTFGMCTIHSPADGSTFDGVLFRFTTACTYVLAKTCSPTETLPMFAVEVVNEQHDNTSLPEVQKININMRIYRVSLLKSQTDRVVINGIWRKLPLSLNSDTVNIRSTPTTIVLATTFGLTVSFDSTGVVHVTLPSTYSDKVCGMCGNFNHLKEDDFRNLDSQNATALAESWQTGKTASSCETILFPQCDPLEETQYASELYCGGLFSTTGPFADCLSVVGADSYIRGCVFAMCSTHGDQAVLCETLRVYIDICNKAGIAVPMLRNSTICPIQCGENSHYNSCADGCPEVCSSLDIAGSCGSCEARCECDSGFKLSGEKCVPAEDCGCWYNGKHYEKGEILVEGDCVQQCQCMGNNNMQCTQMQCADNEVCKVKDGVKGCFLFKPTTCSVYGDPHYITFDGLAYDFQGGCSYILTTTCGGGSSVQFTVSGHNTHPPLQNFTRSKLQAVALQVEDLYLILNQSGEVYQVQLPYSTSGTYGSVWVYVKNNHIILETTFGLKMHIDGENRLFLQVDEHYKYELCGLCGTYSGYQDDDFVTPGGQNVSETFEFGDSWRVPNNSECLARPNNPRLCDKDERDTAYNECSVLFGSVFMPCHEHIHPSIYLNSCVYDYCATSGDQHTLCESLKSYATACQVSGVELPNWQTGTACEGLSTSTAPPTTASPTPDQTFCPLNCNFEKDLCGWEQLMQDTFDWTKHSGPTPTNLTGPNQDHTTGAGFYMYLEGDSVTHGDSARLMSSACNFNGSLCLYFWYHMYGSATAMALNIYLLKDSKTTKLWSMMDNQGPEWHLGRADVKVSGPFQIIIEGIRGSNYQSDVAIDDISVHFGSCSGNKGKANSPDSRPPLQPVCQFHCNFEQDLCQWNQLITDAFDWTRNSGKINASYGDTARLISSECSDSGPQCLQFWYHMYGSADTMGLHVYLLQNRIANQVWRKQNDQGNMWHLAQVDIEPTTPFQIIFEGRRGSNTQSDVAVDDVSLYHGRCAELVNPTTTTTQSKPETTAGPQPSTTTQLKSETTAGPQPSTTTQLKPETTAGPQPSTTTQRKPETTAGPQPSTTVEPQPTTNKPQSTTTARPQQTTLTVPTPICPRYSHYTTCVPACSPTCFFLNGPPHCSDNEVCVPGCVCDDGFVMKMKICVPLEQCGCVDKNGTKHQFNEQWYTDHCSQKCECEKDDGIGKIDCDDEDECDGNAVCLQNEKGNYYCQSTGNFDECTIKKDPEYKTFDKMKHDFEGEHSYVLVRTSNLPNNLQDIYIESINTPVLDQGGDSQHENDSSSEEEQKSREGDDDDDDSKEHDEHHRLQELKIRVYNHTVEFKKNWKLIVDGKPTEMPVSVTGGLKIWKRSSHIYLQTDFGLSVAFNGHHSAEITLPHIYKRKVGGLCGNFDAQRKNDRMKPDGTIARSTKEFGESWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYN5</accession>
    <name>A0A3P9CYN5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PurE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557214.2">
        <property type="nucleotide sequence ID" value="XM_004557157.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CYN5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026931"/>
    <dbReference type="Ensembl" id="ENSMZET00005027795.1">
        <property type="protein sequence ID" value="ENSMZEP00005026931.1"/>
        <property type="gene ID" value="ENSMZEG00005020089.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101476340"/>
    <dbReference type="CTD" id="10606"/>
    <dbReference type="GeneTree" id="ENSGT00390000010172"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01416">
        <property type="entry name" value="SAICAR_synt_Ade5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000183">
        <property type="entry name" value="Probable multifunctional protein ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000020">
        <property type="entry name" value="Probable multifunctional protein ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000006">
        <property type="entry name" value="Probable multifunctional protein ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02045">
        <property type="entry name" value="PurE_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033626">
        <property type="entry name" value="PurE_classII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050089">
        <property type="entry name" value="SAICAR_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43599:SF11">
        <property type="entry name" value="BIFUNCTIONAL PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE_PHOSPHORIBOSYLAMINOIMIDAZOLE SUCCINOCARBOXAMIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43599">
        <property type="entry name" value="MULTIFUNCTIONAL PROTEIN ADE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="14">
        <location>
            <begin position="866"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115518" checksum="B738B8428E7D483A" modified="2019-02-13" version="1">MERGAERQRGGDSEVGEEKGSVERQWGEAEVLALLSVWDQVGAQHVVESRSTFEVISERLRRLSVVRSWRECQAKCRSMRLQSRKADAGTSANYSQGVEERPLERPWEEEDVDNQRRIYPVQEGMKTRFHSAVSYSTNVAEEGGRHWTDDEVRALLCVWADRNIRERLKCTLRNKSIFQEMARQMQRNFGVIRNWKQCRTKYKNLKYDYKTAKSAHAAGGSSAGSPGKYMKFFDEVEAILLDKGLENGTREMQKRLYDGEMEAGRLQTAAGHTGQITGSKSEVVIEIDDDDNSDDYDMDGEMEVKWRSADAHLAHTDSSSDQFQVVTVSDTGRNWSDQEVRALIQVWSDERIRRQLESSTRKRDIFVQISNRLMQQGIERDWKQCHTKYKNLKYLYRSLQRGKTDEADPRRLMRFYEEVDSIMNRTANDSLRDTGAAESADSGGLTTSDNCDEKNHVDGKLTNTRRAVEGALEDKTCTSDSDLSVTIEATSNAYEPKRHKIKEHYLDQEHMLMSASESVVEREDTTSTHRRIKRKAVDEDPGLHTPLKKLNIGPLVAERLHSQCKEETDHIPIIKINSVCSMATPAPSPELQDCSGSTSAMASTPELKVGQKLNEGKTKQIFELLDQPGLVLVQSKDQITAGNAVRKDQMEGKAAIANKTTSCVFQLLQESGIKTAFVKQHSDTAFIAAHCEMIPIEWVCRRVATGSFLKRNPGVKEGYRFSPLKMEMFFKDDANNDPQWSEEQLLEAKFCLAGLTIGQCEVDIMNRSTVAIFEILEKAWATQNCTLVDMKIEFGVNVKTQEIVLADVIDNDSWRLWPAGDRSQQKDKQVYRDLKEVTPEAMQMVKRNFEWVSERVKLLLKPQASSRVVVLMGSTSDMAHCEKIRKACTSYGIPCVLRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVINCPPLTPDWGSQDVWSSLRMPSGLGCSTVLSPEASAQFAAQIFGLSDHLVWCKLRASMLNTWVSLKLADKKLQACSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D0H6</accession>
    <name>A0A3P9D0H6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">HERV-H LTR-associating protein 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D0H6"/>
    <dbReference type="Ensembl" id="ENSMZET00005028467.1">
        <property type="protein sequence ID" value="ENSMZEP00005027591.1"/>
        <property type="gene ID" value="ENSMZEG00005020578.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163670"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16091">
        <property type="entry name" value="IgV_HHLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000142">
        <property type="entry name" value="V-set domain-containing T-cell activation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF14">
        <property type="entry name" value="BUTYROPHILIN SUBFAMILY 2 MEMBER A2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018044507" evidence="12">
        <location>
            <begin position="21"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="134"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="219"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="393" mass="44536" checksum="1FC042246A3BE3AD" modified="2019-02-13" version="1">MVRQRSSYLLLWIFLTIVDGDTEVSCVFMERCVLPCSFKIGNEIVIHWFKTPRDLHVHSFYYSRDQLGNQDQYYRNRTSLFKDQISSGNASLQLTSVEVQDEGRYKCHTSTITGNQESFVNLKVDAPVNKVKMNQVENRISCRSEGIYPEPQLTWSTSPPSNITFTNTTTVNQTEQQLYNISSSLILSAGVYHLLFICTISTRRNRRRATLQRLSDISGPSTGVTIPCTPSNTSLTNFTLLWRFNHTQTVLSQSWTDVTYSVSDGWRQKVENVSKSGSLMLKDLSTKQEGMYTCKLSNAEETHITHIHLRITEGARSNTAVITTAVMCGLVLIGLSIAALISIRSYPLLLTRYRHAAFVSSSQTRMDSVLFRVTTKRNLILLPDEEQSKNIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D185</accession>
    <name>A0A3P9D185_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 45a</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557102.2">
        <property type="nucleotide sequence ID" value="XM_004557045.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004557103.2">
        <property type="nucleotide sequence ID" value="XM_004557046.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D185"/>
    <dbReference type="Ensembl" id="ENSMZET00005028847.1">
        <property type="protein sequence ID" value="ENSMZEP00005027957.1"/>
        <property type="gene ID" value="ENSMZEG00005020853.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101473722"/>
    <dbReference type="GeneTree" id="ENSGT00940000155530"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006904">
        <property type="entry name" value="DUF716"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042127">
        <property type="entry name" value="TMEM45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007">
        <property type="entry name" value="EPIDIDYMAL MEMBRANE PROTEIN E9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16007:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04819">
        <property type="entry name" value="DUF716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="277" mass="31883" checksum="79ADE7EF18130C94" modified="2019-02-13" version="1">MGSFRGHALPGTFFLVAGIWWTVKYSIWHATRRNKGIGSTRLASRASQRRLEIIESSVILFFSLVGMLAEQFGSGGPKLQLYNFVEKHWDHLHSWHHATMYLFFGLFATVSLIIHTTEAAPLSLDRLMLAIAFFNEGFLFLYHLHGRSMLDVHVHLLLLYAVFGETLVAFLEIFHRGNIILELLRCTLTVVQGTWFWEVGFVLYPPRGPEWDLKDPNNMMFITMCYSWHLAFAMLIVSVLYCIVSCAVRSRLKKTPPVEMGLLKARERDPESEDELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3X6</accession>
    <name>A0A3P9D3X6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COMM domain-containing protein 6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012779206.1">
        <property type="nucleotide sequence ID" value="XM_012923752.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3X6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029059"/>
    <dbReference type="Ensembl" id="ENSMZET00005029977.1">
        <property type="protein sequence ID" value="ENSMZEP00005029059.1"/>
        <property type="gene ID" value="ENSMZEG00005021668.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481024"/>
    <dbReference type="KEGG" id="mze:101481024"/>
    <dbReference type="CTD" id="170622"/>
    <dbReference type="GeneTree" id="ENSGT00390000018369"/>
    <dbReference type="OrthoDB" id="10251827at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF5">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="4">
        <location>
            <begin position="132"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="199" mass="22413" checksum="F2F445876F40B90A" modified="2019-02-13" version="1">MPAAEESYGVNKVVDNICRISPDLLADVCQHVLTYLQGQKRGVDSAEISDRFQRAEVRLDHEALQDMIRFLLLTFRSAGKSNISGDELVSKLEEGSTKWTKASLQVLHKLWSEHGVSVHTQQEAQAMLSIGQLVDMQWKLGMAVSSDTCRSLNSPFVCLLLKIVEPSGQICQRSFEMTIPQFQNFYKQFKEMAAVMETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4H6</accession>
    <name>A0A3P9D4H6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphodiesterase</fullName>
            <ecNumber evidence="10">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_004546711.1">
        <property type="nucleotide sequence ID" value="XM_004546654.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4H6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029249"/>
    <dbReference type="Ensembl" id="ENSMZET00005030167.1">
        <property type="protein sequence ID" value="ENSMZEP00005029249.1"/>
        <property type="gene ID" value="ENSMZEG00005021791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474739"/>
    <dbReference type="KEGG" id="mze:101474739"/>
    <dbReference type="CTD" id="5150"/>
    <dbReference type="GeneTree" id="ENSGT00940000157658"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000004">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="12">
        <location>
            <begin position="153"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="469"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="474"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="229"/>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4M1</accession>
    <name>A0A3P9D4M1_9CICH</name>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="10">Promotes matrix assembly. Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="515" mass="56540" checksum="E946A2819098548B" modified="2019-02-13" version="1">MEGHMLFAWMLMCLLLRPSTAQNSPPEGVLNCCEGDILFLVDSSGSVSSYEHSRMLAFLSELISPFSLGEDQVRVGLLQVGTKPRLEFGFDKYSTQSGLQAALKTIKPLRGDTNTVEALKMVKEWVLRPGKAGGARENLPRVLVWLTDGVKPGDVTGPMAQLRDDGVAMLVVSTGHGNYQVLRQVVSPPVEDHLHFVDIDDMSIITKEFRDAIIEIIRAERIHVRDVSTSSATLQWRPVLSGLTGHYEILFKELRRGVGGVETSRPDVFTGGPPYQRLTQTADSSTARLTGLKPDTNYIAILRPESNEQAFNDLHVTFRTRPEVLSPAVVTVSEPGQSSVRVSWGPLQPGMVESYSVEYSALPTGKVHYVQLSRSQNSTLLRNLQPDTTYLVTVTARHASGKEKAMSVKVCTQEVTPALADLQLTTVGSDSVEVEWNGGTSHLRGYWLTWEGQQSSAPGQRSSLYLPPDSLSTRLTHLPPSARVCVSPIYRTARGEGLCCTAQFHSDALVYGYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4M7</accession>
    <name>A0A3P9D4M7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GABA(A) receptor-associated protein b</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004571245.1">
        <property type="nucleotide sequence ID" value="XM_004571188.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4M7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029162"/>
    <dbReference type="Ensembl" id="ENSMZET00005030080.1">
        <property type="protein sequence ID" value="ENSMZEP00005029162.1"/>
        <property type="gene ID" value="ENSMZEG00005021737.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483169"/>
    <dbReference type="KEGG" id="mze:101483169"/>
    <dbReference type="CTD" id="326974"/>
    <dbReference type="GeneTree" id="ENSGT00940000166995"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17232">
        <property type="entry name" value="Ubl_ATG8_GABARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000037">
        <property type="entry name" value="Gamma-aminobutyric acid receptor-associated protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="10">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="122" mass="14548" checksum="EF326445CC1D581C" modified="2019-02-13" version="1">MKFQYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGLLYQEHHEEDFFLYIAYSDESVYGDSQREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4T6</accession>
    <name>A0A3P9D4T6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Parahox neighbor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OHCU decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004546738.1">
        <property type="nucleotide sequence ID" value="XM_004546681.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4T6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029354"/>
    <dbReference type="Ensembl" id="ENSMZET00005030277.1">
        <property type="protein sequence ID" value="ENSMZEP00005029354.1"/>
        <property type="gene ID" value="ENSMZEG00005021895.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481721"/>
    <dbReference type="KEGG" id="mze:101481721"/>
    <dbReference type="CTD" id="646625"/>
    <dbReference type="GeneTree" id="ENSGT00390000002395"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051997">
        <property type="term" value="F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3330.10:FF:000001">
        <property type="entry name" value="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017580">
        <property type="entry name" value="OHCU_decarboxylase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03164">
        <property type="entry name" value="UHCUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466:SF1">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="14">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="174" mass="19547" checksum="36BF2296BC431A69" modified="2019-02-13" version="1">MDISAVNALSYEDFVNTFGNVVEKCPVITAAVWSRRPFVSLNALEAAISDFIDELPESGKEGILRCHPDLAGRDLQRGTLTRESRQEQAGAGMDALTSGEAERMARLNEEYKKRFEFPFVICARMNDKANILLQLSERCQNERAVERARGIEEVKKICRLRLQSLLLTDGANKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D507</accession>
    <name>A0A3P9D507_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_004546586.1">
        <property type="nucleotide sequence ID" value="XM_004546529.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004546587.1">
        <property type="nucleotide sequence ID" value="XM_004546530.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D507"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029419"/>
    <dbReference type="Ensembl" id="ENSMZET00005030347.1">
        <property type="protein sequence ID" value="ENSMZEP00005029419.1"/>
        <property type="gene ID" value="ENSMZEG00005021945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466317"/>
    <dbReference type="KEGG" id="mze:101466317"/>
    <dbReference type="CTD" id="23556"/>
    <dbReference type="GeneTree" id="ENSGT00390000017600"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol glycan anchor biosynthesis, class N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol glycan anchor biosynthesis, class N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
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    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="789"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="894"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="13">
        <location>
            <begin position="433"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="933" mass="104767" checksum="0523DAA6909C0574" modified="2019-02-13" version="1">MRMITFFVIGLTVHVVFFISIFDIYFTSPLVHGMTPHSTPLEPPASRLVLVVADGLRADSLFTLLPNGSSRTPYLRSIIEDKGTWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSVFNESRHTWCWGSPDILPMFAKGASGDHVYTHTYPAVEEDFASTDASKLDSWVFTQVKSFFKSAQSNSTLKASLWEDKNVFFLHLLGIDTNGHAHRPMSQEYLDNIGLVDAGVAEVVSIIEDFFDNDGRTAYVFTSDHGMTNWGSHGAGHPSETLTPLVAWGAGVQKAKGATEPQPYNDGFLQDWKLEHLRRVDVSQADIAPLMASLVGVPIPVNSVGVLPLLYLNNSERFMAESMYTNAIQVLEQFKMKMMQKKETTLSFLFTPYQLLTESKQAEFTQKARILIQLEKYEDAISLCQSLISRSLEGLVYYHTYDRFFLGCSVVLGFVGWTSYVVLVILKTHASLNRHPNLTKQIPGRNLARLCTCVAVVITLFLLIQRSPITYYIYCLLPIPVWYSVLKESGTLRDLIQTAPSLPLWKCLGYFVLVAFGIELLVVSFFHRAMLTVGLAVLSLWPFLSGLFGKAKSRSLSWLVGCLCLAAFPLMPVVGREPNIHLVTCAGLLALFTSACYLWSSRRRTPLHLGDRPQFVIQMLLVAVCAYVPSLTHSSLQQKQGLPLLNQIISWSTLASSIFVPLLSSTRLFHRLLSIFLSLTSTYLLLSTGSEALFPPVLSWLMFVWINIEQEALLAQGMSGRQELSTIDFSANIDITKIRQLKLDDIRRSYFFVFFIITAFFGTGNIASINSFDPASVYCFLTVFNPFIMGGLMMWKVIIPFIIVMCTFETIQVATQLSSRSLFLIVLVISDLMALHFFFMVQDYGSWLDIGTSISHYVIVMSMTIFLMLLSVVTHVLTSQRLVLWRQRKMHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6L9</accession>
    <name>A0A3P9D6L9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrator complex subunit 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005030228"/>
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        <property type="protein sequence ID" value="ENSMZEP00005030228.1"/>
        <property type="gene ID" value="ENSMZEG00005022523.1"/>
    </dbReference>
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        <property type="component" value="LG4"/>
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        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of locomotor rhythm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sleep homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034474">
        <property type="term" value="P:U2 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="INT1_R3"/>
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    <dbReference type="InterPro" id="IPR038902">
        <property type="entry name" value="INTS1"/>
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        <property type="entry name" value="INTS1_INTS2-bd"/>
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        <property type="entry name" value="INTS1_R4"/>
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    <dbReference type="InterPro" id="IPR022145">
        <property type="entry name" value="INTS1_RPB2-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21224:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22927">
        <property type="entry name" value="INT1_R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22929">
        <property type="entry name" value="INTS1_INTS2-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22928">
        <property type="entry name" value="INTS1_R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12432">
        <property type="entry name" value="INTS1_RP2B-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 1 RPB2-binding" evidence="2">
        <location>
            <begin position="322"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 INTS2-binding" evidence="5">
        <location>
            <begin position="969"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R3" evidence="3">
        <location>
            <begin position="1826"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 1 R4" evidence="4">
        <location>
            <begin position="2036"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2175" mass="243685" checksum="63BD252694B4930F" modified="2019-02-13" version="1">MNRPKPTTLRRPSAAKPSGHPPTGDFIALGSKSQGGEPKAPAVLLKATSTNLPADRKRETSSTLPSSSGLANLTKRPKLSTTPPVSALGRLADVAAVDKRAISPSIKEPSVVPIEVSPAVLLDEIEAAESEGNDDRIEGLLCGAVKQLKMNRAKPDITLYLSLMFLAKIKPNVFATEGIIEALCSLLRRDASINFKAKGNSLVSVLACNLLMAAYEEDENWPEIFVKVYIEDSLGERIWVDSSHCKNFVDNIQTAFGTKMPPKSMLLQADTGRSAGDLSAGSSPHPSTPDEDDSQTELLIAEEKLSPEDEGQVMPRYDELAESVEDYVLDVLRDQLNRRQPMDNVSRNLLRLLTATCGYKEARLMAVQRLEMWLQNPKLTRPAQDLLMSLCMNCNTHGADDMEVISNLIKIRLKPKVLLNHYMLCVRELLNAHRDNLGTMVKLVIFNELSNARNPNNMQVLHTVLQHSPEQAPKFLAMVFQDLLTNKDDYLRASRALLREIIKQTKHEINFQSFCFGLMQERKEASYVDMEFKERFVIQVTDLLTVSMMLGITAQVKEAGIAWDKGEKKNLEVLRSFQNQIAAIQRDAVWWLHTVVPTISKLGAKDYVHCLHKVLFTEQPETYYKWDNWPPESDRNFFLRLCSEVPLLEDTLMRILVIGLSRDLPLGPADAMELADHLVKRAAGVQSDDLEVLRVERIQLIDAVLNLCTYHHPENIQLPAGYQPPNLAISTLYWKAWLLLLVVAAFNPQKIGLAAWDGYPTLKMLMEMVMTNNYTYPPCTIADEDTKTEMINRELQISQREKQEILAFESHLAAASTKQTITESNSLLLSQLTSLDPQGPPRRPPPQVQEQVKSLNQSLRLGHLLCRSRNPDFLLNIIQRQASSQSMPWLADLVQSSEGSLDVLPVQCLCEFLLHDAADDSLLIDDDEEGESKEQKAKKRQRQQKQRQLLGRLQDLLLGPKADEQTTCEVLDYFLRRLSSSQVASRVLAMKGLSLVLTEGGLKDGEERDQPMEEDSADAELLPGYQWLLQDLPKLPLFDSVRGMTSTALQQAIHMETDPQTISAYLIYLSQHAPVEEQASHNDLALDIARLIVERSTIMNNLFSKHSSRPESDAVLYAFLSIFSTYIKRMRKTKEGEDLYSWSESQDQVFLRWTTGETATMHILVVHAIVILLTLGPPKESDFHMLLDIWFPDKKPLPTAFLVDTSEEALLLPDWLKLRMIRSEVSRLVDAALQDLEAQQLLLFVQSFGIPVSSMSKLLQYLDQAVSHDPQALEQNIMDKHYMAHLVEVQHERGATGGHTFHSLLSSSLPPHRDSSETSKAKVTVETPHSSVKMRAATQLPVVGPDDDLTGMLLQIFPLKVDPRWHGPPPSQVSLALQQALAKELMRAKQGQIQQGGLAFRLLQAIAALLASAHAGPIVISMHRSHSLSCPLMRQLHLYQRLVSQDIAFSSLFLKVIVEMLIWLDNPTVEAGPLKTLLRSFAGQNSHKHRLSDVRTGFLHLAEALAYRRDTEVPLRAIIAMLKTGEKCNAEPELVGKVLQGLMEVKSPYLEELLSLLMTVGTQNGTAGSVAMVISLLLQESEERAVKKEVDSNNGSEVTKSGLSSGLLVDWLERLDPEVTSVCPDLQQNDASFLTVYLPYLLALLTHQSNWSTLLQCISALLSKRRDYKLDPSSALDFLWACSHIPRIWQGRDQKIPQKKTEKFVLRLSSEELISLMDLILSESELNSHDTLQDDKNSVDQAPCSLIQSRLPLLHSYCNGNLEDIKKVSEYLINCSKKWEDSAMSKRCQNLLLQIYLHFPEVIQHVALPESTFSSGGAADGSSCKLDVLVHRLVTLLADIGDSKSAESRVSDANLACRKLAVSHPVLLLRHLPMIAGLLHGRMHLNMQEFRQQNHMTFFSNVLAILELLQPLVFHSDHQRALQDCLLSFMKVLQRTRSPLVFINKFLQFTQKYITHDGAAAIPYLQKHSDILHLCAENPDLVQLKSLLAGLTLPVKSSSAEVSTEERDDDLAAGSLPLVNISASFLLSAADMTMYLKKMSKGEAVEDVLEVLTEVDEKSRRSPEIIQYFINDLQRLMTSPEELCRNMAFSLALRCIQNNPCLATDFLPTFMYCMGSGNFDVVQTALRNLPEYVLLCQEHADILLYKAFLVGIYGQIDTSSMISESMKVLHMEATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8D4</accession>
    <name>A0A3P9D8D4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Virion membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8D4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030366"/>
    <dbReference type="Ensembl" id="ENSMZET00005031319.1">
        <property type="protein sequence ID" value="ENSMZEP00005030366.1"/>
        <property type="gene ID" value="ENSMZEG00005022629.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064449"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424:SF81">
        <property type="entry name" value="ERVV2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="VIRAL ENVELOPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58069">
        <property type="entry name" value="Virus ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="7" id="KW-1043">Host membrane</keyword>
    <keyword evidence="5" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="470" mass="52630" checksum="15535F7739557042" modified="2019-02-13" version="1">MHSSRSLKSVNDNIDATNKPFYAPSRVGVNSWYENARTAARDLGNSNCYVCSKGNPEQVIVGYPISGFPLTKMLFKNDEKGPLTVTLIEAVRVELSPLDCLLIYTGQVSSKDVSMINDSTHPCNPMKRPEDRTEPLSPPKQVRHHPNILMTCIHRPKLENINYDAQNYTFFSDSPGARCNETWLAASVDRTQHRHLFSYLYAYINTHSDNSTILHSPNTLNDSYWGGILKGFTASLLTRPIPHAYWMCNNTLRVALPVNWTGTCGLVTLAQELLIQQTSDLELKAQGEISAGFVSLIPHIQVNKNVAWINYVYYNQQRLTNLTNTALKALGEQMSATSLMTMQNRMALDMLLAEKGGVCAMFGDVCCTFIPNNTAPNGSFTQAMNKLEALQIELRANAGHGQWIDKWLQDTFGKWKELIVAFVTIVACIILFLMIIACCVVPCVRSMITRMATSTKEETSRYCAKQQQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8Z1</accession>
    <name>A0A3P9D8Z1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cyclin D1</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PROTOR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclin family. Cyclin D subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D8Z1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030572"/>
    <dbReference type="Ensembl" id="ENSMZET00005031534.1">
        <property type="protein sequence ID" value="ENSMZEP00005030572.1"/>
        <property type="gene ID" value="ENSMZEG00005022773.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157816"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000120">
        <property type="entry name" value="G1/S-specific cyclin-D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF3">
        <property type="entry name" value="PROLINE-RICH PROTEIN 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="15">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="16">
        <location>
            <begin position="157"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="659" mass="74126" checksum="61D3DB5BFD1F2CF5" modified="2019-02-13" version="1">MEPQLWCCEGDGPPIPRAYRDSNLLTDRVLHALLRVEDMYLPAPNYFKCVQREISPYMRRIVAAWMLEVCEEQKCEEEVFPLAMNYMDRILSVEPTKKNHLQLLGAACMFLASKLKETIPLTAEKLCIYTDNSVTPSQLLQMELLVLNKLKWDLASPTPLDFIDHFLSQLPVNKENKSTLRKHAQTFVALCATDVKFIASPPSMVAAGSMVAAVEGLQMRMVGNTMMSQKLTEQLAQTIKSDPDCLRACQEQIESLLETSLRQAQQQHSFAMETKKMGEDHSATPTDQPASIMGSFRRPRPRFMSSPVLSDLTRFHASTPALQISNITVWNRVQSAVIKVFKGGALQTNELYTLNESIRWLLKTEMGSFITEYFQNQLLSRGLSGVLEQILLQNSDTDDNQLNVLACMWDQFFTETLPTLQAIFYPVQGQELTVRQMALLAFRDLVLLKLHLEDTLGNATSIPPSVTQMLLVLQGIHESGVPSSEYHRLESLVEIVVSPYICNVLHNRNSHQLEPCHLRSSEALLGDQSQPEIMITQHHSSLDSSSLSPLVEQEGEAYLEKVGGVRRHTVANAHSDVHLLSVSNKMHAGMENSRGEEEQGVVGFLVGAKPMSPMNFCRQLVMGDSPNCSEDIGYVRQNKMKNFRVTNETNCRKKLAGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DAP4</accession>
    <name>A0A3P9DAP4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sleeping Beauty transposase HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DAP4"/>
    <dbReference type="Ensembl" id="ENSMZET00005032218.1">
        <property type="protein sequence ID" value="ENSMZEP00005031211.1"/>
        <property type="gene ID" value="ENSMZEG00005023274.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177428"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057667">
        <property type="entry name" value="HTH_SB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25787">
        <property type="entry name" value="HTH_SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sleeping Beauty transposase HTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="575" mass="64574" checksum="C3B286352844A077" modified="2019-02-13" version="1">MPRKKELSEDLRAKIVDLHKTGKGYKIIARTLGIHLSTVREIVHKWRRFNTVATLPRSGRPTKTSAKTKIINEAGHGSTEPKGNRRGDSNHKKAHHGSAGPADDRTDSDHQTATHVSAGPTDDRRGDSEHVMHIARDNTVYNDGDTDCYSSDSDEDEDPTASHLSAGKAETKEHQEPTSCASCDDETTEEDPTEQFFCGEKKIYAGSSVTMGALLLLLLAFIVKHGLSKAASRDLLHLLNLVVPGCVPKSLRFLKKHSTDYNGKTEIHFYCPRCTNYLGVDPGNECSVCQQSLSRKYLILKAYYFLVMPLEIQLRNLLARVHSKLGKHFTRDDSFSDVHTGNKYKSERQDGSITLTFNCDGSSVFSSSKYSIWPILCTINELPYVERCKNVLLHTLWFGKGKPQVQSFLTPFINELQKLSAAGFCWKDEIGSEHHTTVTVKICTCDAIARAMVQNFEPFNKEFGCGFCYHKGEMVIKGRGFTRVYPIQMDGCDLRHMPETVQLAELVMGNSYDQSQMGVKGPSLLFLLPSFDIIKGFVPDYMHCFCLGVVRQFVNLWFDPLYASKDFHLTDEHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DB31</accession>
    <name>A0A3P9DB31_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sterile alpha motif domain containing 10</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DB31"/>
    <dbReference type="Ensembl" id="ENSMZET00005032612.1">
        <property type="protein sequence ID" value="ENSMZEP00005031584.1"/>
        <property type="gene ID" value="ENSMZEG00005023560.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008161"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09510">
        <property type="entry name" value="SAM_aveugle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039144">
        <property type="entry name" value="Aveugle-like_SAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052268">
        <property type="entry name" value="SAM_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20843:SF1">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018330373" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="186" mass="21250" checksum="5BC6552AE96C1541" modified="2019-02-13" version="1">FCFICWFFFFALLSAASSFSFCRASLEHTVSAEELSYQLPRHAGGSNLTWHDGRGQKTAHTRTVKLLQQPGTEGIQLRPGEAFTVYHTSPTLSSLSKPVVLWTQQDVCKWLKKHCPHNYLTYVEAFSHHAITGRALLRLNGEKLERMGIVQETLRQEVLQQVLQLQVREEVRNLQLLSRTSFGNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCE3</accession>
    <name>A0A3P9DCE3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCE3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031787"/>
    <dbReference type="Ensembl" id="ENSMZET00005032820.1">
        <property type="protein sequence ID" value="ENSMZEP00005031787.1"/>
        <property type="gene ID" value="ENSMZEG00005023706.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015224"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000005">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="81"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="167"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="260" mass="29420" checksum="A211E362430B6C6B" modified="2019-02-13" version="1">MFEKLAVKNNNRKRCSLTFGIFLVVCDTSVQIFTSKICAPRSSGNACWWHVQLRGDVVLSSFPLLPARMKTILSSQTVDLPDNVEVRLKGRTVTVKGPRGKLTREFNHINLELSLLGKKQKKLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQESGTLVEIRNFLGEKYIRRVRMRGGVLCSVSAAQKDELVLEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVLEPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGG7</accession>
    <name>A0A3P9DGG7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">H-2 class I histocompatibility antigen, Q9 alpha chain-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGG7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033553"/>
    <dbReference type="Ensembl" id="ENSMZET00005034702.1">
        <property type="protein sequence ID" value="ENSMZEP00005033553.1"/>
        <property type="gene ID" value="ENSMZEG00005023962.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271828"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000943">
        <property type="entry name" value="Classical MHC class I molecule, alpha-chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
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    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF237">
        <property type="entry name" value="MHC CLASS I ANTIGEN TRANSCRIPT VARIANT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="189"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="371" mass="42128" checksum="4D2532E410D09906" modified="2019-02-13" version="1">MQRKKNKDPTNPIHKLRQIQLLLLLLNIFLTHSLQYFYTASTGIERFPRFVAVGVVDGEQIDYYDSVSEKNVLKQTWMEGVRDESRITDIRRGAQQSFQGNIGIAMERFNQTTGVHIFQWMYGCEVDDETKELNGYEQFGYDGEDFITLDTKSGSWAAPKQQAVITKHKWDSDTANTAYKLDYYTTICPDWLKKYLNYGKSSLMRTVLPSVSLLQKSSSLLVTCHATGFYPNKAELVWRKDGVEFHNGVHKGEILTNNDGTFQMSADLNISSVPAEDWRMYDCVFQLAGVNKDIVTKLDREVLKTNEGPSGFPVGAVVGVVVGAMVLLGVAALVYFKCFKKENDGKDQKIFSLFTMTIYLKFPSVLVLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGZ2</accession>
    <name>A0A3P9DGZ2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Desmoplakin</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the organization of desmosome cell-cell junctions. Of particular importance in cell adhesion in the skin and during cardiac development. May also play a role in the regulation of Wnt, TGF-beta and Hippo signaling pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the plakin or cytolinker family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005033659"/>
    <dbReference type="Ensembl" id="ENSMZET00005034832.1">
        <property type="protein sequence ID" value="ENSMZEP00005033659.1"/>
        <property type="gene ID" value="ENSMZEG00005025162.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154843"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002934">
        <property type="term" value="P:desmosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031101">
        <property type="term" value="P:fin regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060047">
        <property type="term" value="P:heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.780:FF:000001">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000001">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000002">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="plectin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041573">
        <property type="entry name" value="Desmoplakin_Spectrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF26">
        <property type="entry name" value="DESMOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00681">
        <property type="entry name" value="Plectin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18373">
        <property type="entry name" value="Spectrin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21019">
        <property type="entry name" value="Spectrin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21097">
        <property type="entry name" value="SR_plectin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Desmoplakin SH3" evidence="13">
        <location>
            <begin position="447"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Desmoplakin spectrin-like" evidence="14">
        <location>
            <begin position="547"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1413"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2653"/>
            <end position="2691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="381"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1469"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1672"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2653"/>
            <end position="2664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2665"/>
            <end position="2691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2709" mass="309393" checksum="9987EFC8890DAC4D" modified="2019-02-13" version="1">MSLYGSQSKLPMSGMSRSTSRPELSNYRNDVFGGNGFQGEYQAGDGGVTYTFSRHSVHGGGVGGQNMQVSMGGGGGAISANAIQQKAAFLQQQCHEQLERANMILRTGGSMKDAERFLLLAEESIEQLRNCSQTMNQLRIPNGIFRSIEQFQHMHGTIAQQLVGSVTIRRNRGSGSFEGGKLFNDAMGWISQQKRMVETAPWGDDSAAIEKQILSHNSFHSSIQRSSEVERARDELSANGEKYHLSLLDQEWESMMKMSHSRLNQLRELQNIIEEISQAIIWVNEREEEELIFDWGDKNIDYYIPKKQESYSRLMRDLEVKEKDLNKLKVKSDSLLANSHPASDKIDAYMDTLQTQWSWLLQITKCIHVHLKENSAYSQFFKEANETYMKLQKQHETIRSKFTCDKNTPLDKLTELLKNLETEKARIMENKRQVQSLVSKSKSIVRLKPRNPEEKSSGPIMVQALCDFKQDQKGIMKGNEGILKDNSQRSKWLVTGPGGLDMMIPSVCLLIPPPNPLSIGIATKNEQYYEAIMSIWNQLFINIKSLISWQYCLKDIDYINSLTITMLSKMRPEEYRNVIKGLETHYQEFMRTSQGSEMFGEEEKKLMQGNFDKAQAHYDTLVIQLPAYREKETESLKVEKVKVTKISTPKPNNQTAPPSSSLSLTLLTSLHELRRRLELAESGLTSHLHIPLGDNSVYECSVHIQKLQTMNQDLDSIYDEYLRLREMITKQLEGIPADSEQAKFLRAELDVISQKLAGLQDLQSTYLQRLSALKALLQSLIQVEDIIKVHEARLTEKETSSLDPRELENQRLTLKQMKSDLEQKRDLLTSMESELSTAVHLNGQISDSFHKCDIDLSKYSVLVRQLTDRWRRIQSQIDSRVWDLEKQGNQLKHYQQGSTSLEQWIDNARKRQDTLQTIKISDIQTLMDHLNQQKALHSEIKGKKEKVEDVQKNADTCAASIKDYELQLASYSSGLETLLNVPIKRTMLQSPASAVRQEAGDLQTHYIELLTRSSDYYKFLGELLKNMEELKIRNTKIEMLEEELRRLKEDLNDRNQKNKSLEDAMAQYKMELSQLQDQVICTEEVKRTSVIQVNAAKESLDSTQSKLHELNDELTRIKYQLDEEKRKRRLAEERYNSQQEEYEGAVRRRQKELEELSWTKIDLEKAVKDKEREVERMKMQLEEEAARRRNAESEMSKVRTQCTQEINQLKQTYETEIHVTKTTILKASQQKEEDATELRLQLERLAAEKRDVEEELRRLRQAIAITEEQKSRAEQEVNQQRASVAQETRVRSELEVQLITLKQQREENELKLKESTRNNQEKSREISVLTFNLEEEGKKRRALELEINHLKQAEAELKTKNTSYQETINKLKVSEQEIRITRVELEKQASEKTKAEQNYARLQSRVRELQSSLDGKEAELAKQKQATQEEFTRRKRMEAELERMTHTCREHTTTISSLKSIQIEASTSGRKYEQDLKALQEALDKSLRDHKATKEELASVTAELKIQKQKLQQELTRIQELNLRNESLYKTIEEKSRQLNEYTTEIEKLKTLTQNLTKERLKLEEELRTVRQEKNEMKLSKDAIDGESATQISALHVQLQSSIKRTSELQGLINDLTNEREKLKSEINKFQKQSIETSLVVQESQSKYSELLLEKDSFLSRIKLLEQDKTRQLRLEEELNRIKVTLESERRNKQQLQEEKNSIFKELSTIKSQYELKSSQIRQCESDRDRADRERLSLKSEIERLMRELTSIEERYKSRLLSSEKEAKELALKKESLEREIRRLQQRPNTLNMQTQTDDKVQTIDPSKLLFDSVRRKVTAHQLCDCGIISKATLDELLKGRRTVSEVAADIQVNLKGSGIIAGMTSTSQRKIPFTEAKNKNMLSPESALKLLEAQAATGYIVDPAFNEKMPVDTACSRGIVDTEDRDTLLKAEAASTGFKDPYSGKVLSVGQACKQGHIDKETTIRLLQAQESVGGILDPVLGVFLPKDLALDRNLIDEDLYRALTKKPTCYLDPTTGQKTTYNDLRMKCTVEPVSGLLLISGPEKPLTVKGLRGEVSVSELIESELLDETDLQKLSQGKLTSRDIEDKLKTYLHGSTCIAGIYDEANDRILPFYQAMKEGLLMRGTTLELLEAQAASGFIVDPVNNVFLTVEDASKRGLIGKEFKNKLLSAEKAVIGYRDPNTGKTISLFQAIEKDLIEKGHGIRLLEAQIASGGIIDPKESHRIDVAVAYKRGYFDEEMNEILSYEGDDTKGFFDPNTKENLTYLQLKERCIKDEKTGLLLLPLRDKRKPQKTQESRTNVLRKRRVVIVDPDTGLEMSVREAYHRELIDYDTFLDLSEQECEWEEITITGSDGAARLVIVDRKTGIQHDIQDCLERGVINQSTLDKYRAGTMTLTQFADEIASRSSSLEMTIAASNVDDMITCSSPTHTTPSSPTVRKRFNSISITVSPPEMFDDHSPVGAIFDTETLEKITVSEALRRGIVDTLTAQRLLEAQACTGGIINPATGERLSLQDAVHQSIIDESMASKLKPAQKAYVGFEDVKTKRRMSAAEAVKETWLPYEAGQRFLEFQYLTGGLIEPGTGRRVSIEEAIRRKWLDGQGARKLQDTRNHQKNLTCPKTKLKISYKEAMDSCMVEESNGMKMLQASSVSTKGISSPYNVSNPGSRSGSRAGSRTGSRSGSRRGSVDYTSTMTFTSSSSTIYSSNTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DI59</accession>
    <name>A0A3P9DI59_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DI59"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033821"/>
    <dbReference type="Ensembl" id="ENSMZET00005035012.1">
        <property type="protein sequence ID" value="ENSMZEP00005033821.1"/>
        <property type="gene ID" value="ENSMZEG00005025292.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164472"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018091487" description="Protein kinase domain-containing protein" evidence="8">
        <location>
            <begin position="28"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="81"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="360" mass="40137" checksum="023525D91ADC9490" modified="2019-02-13" version="1">MHKRLSKTHLFNLSSLILLCTVRMYCSSPLNKQAQFTRETKTSSVLFLTNSQRKLYTMSANPSFGSDELGISKGTILGDHHMVEAFLGEGSFGVVTRCRDTKNNKTVAVKVNKSDPEILLQAKLEIFILEQLRRLDPDRCNIVEWNGYFLDGERICLNFELLDQSLSDYIGDRNNRGLPMREIRPILNQLANALFHLGSVGIVHADLKPVNIMVVNRSESQVRVKLIDFGIACNTSAVIPGDCVGTIGYCAPEIMLGTPYDEAIDMWSLGLVAVELATGVPLYPGEDDYDVLKFIIETQGQLPDHLLESGLRGPENGQTLFVRLIKEMLALDANQRITPSEALKHPFFNPGLSRRTPSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DJJ9</accession>
    <name>A0A3P9DJJ9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin/ISG15 ligase TRIM25-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DJJ9"/>
    <dbReference type="Ensembl" id="ENSMZET00005035776.1">
        <property type="protein sequence ID" value="ENSMZEP00005034563.1"/>
        <property type="gene ID" value="ENSMZEG00005025817.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286931"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19802">
        <property type="entry name" value="Bbox1_TRIM8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="49448" checksum="E24FC8035A8236E1" modified="2019-02-13" version="1">MAQKGVQLDRENFSCSICLDLLKNPVALPCGHNYCMNCINGFWDEEEKKKIYSCPQCRQTFTARPFLMKNTMLAELVEELERIRLQAAPADHCYAGPEDVACDVCTGRKMKAFKSCLFCLASYCEKHLQTHYDVVQLKKHKLVEPSKKLQENICSRHDEVMKMFCRTDQQSICYLCSVDEHKGHDTVSAAAERTERQRELEVSRQNIQQRIQDREKDVKLLQQEVEAINQSADQTVEHSEKIFTELIHLIQKRSSDVKQQIRSQQETEVSRVKELQEKLEQEITELKRKDAELKQLSHTEDHIQFLHNYPSLSALSESTDSSSINIRPLSYFEDVTAAVSEVRDKLQDILREERTNISLTVTEVDVLLSEPPEPKTRAGFLKYSCEITLDPNTANKQLLLSEGNRKATLMKQEQSYSDHPDRFTINRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DKZ8</accession>
    <name>A0A3P9DKZ8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="9">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Inactive ubiquitin carboxyl-terminal hydrolase 52</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="9">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAN2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
            <location evidence="9">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between nucleus and cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="9"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DKZ8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035425"/>
    <dbReference type="Ensembl" id="ENSMZET00005036676.1">
        <property type="protein sequence ID" value="ENSMZEP00005035425.1"/>
        <property type="gene ID" value="ENSMZEG00005026472.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013978"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000011">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000017">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="487"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="912"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="914"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1021"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1073"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1134" mass="128779" checksum="BA5EE6DEAC18592B" modified="2019-02-13" version="1">MLNSPLMIILGEYWWTPGGLEPSMNSYLNPNLHQDVGVYTQELAVTVPEPVHVRKGIFSELHSKVSEAGIPVTATHFDLQREMLWMGNYTGHVKSFLGPTMAHYSSFQVHATDAIRHIQSLDTGVLFLSECNLRCYTRGGLVMFDYRMEEGADMHSLLMTDNMLLMGGLQNYVVEIDMNTLQETQKFRVEAPGVTIMRQTNRFFVFGHPSGKVTLRDLRTFRTQKFDAFPGGLSDFDVHGNLLAVSGFSSRGLNERFLMVYDLRMMRAATPLWVHVDPFFVRFLPTYTSRLAIISQTGECQFCEPTGLANMADIFHVNTNGHFLTSFEVSSSKQALAFGDSGGCVRLWSDTRDVMFNVYSREPCVVDAQPQLAWNHNLQPCSPIPTAQATPSSRWAPGMDPEIPQTIETVGFNSYVENPSACPCNQVPANKEESPGYYNHIPESPTESDEEPLLHTVPEKYRKVTIKYSKRGREDFDFKHYNRTLFAGLEPQIPNAYCNCMIQVLYFLEPVRCLVQNHLCHKEFCLACELGFLFHMLDLSQGDPCQASNFLRALRNVPEAKEMGLILSNCEETTGTVELGRLIQRWNHFILYQLFQETQEQEDPRAYRTTRSSSLGSSGDSVIRELFCSEVENRSPCLCGIETVYSSLMLLFNMHYPNSQGEIKEHDFAEILKKSICLQQRSHTWCGNCDKYQPTVQTRNIRRLPDVLVINCEVNSSKEAEFWKVQAEYAFNKSMQKTDQDQRHVWIPATLKMSLSKSQRLEISSWPEGEELSAAEQAEGASLYDLVATVPHILDAGAGGNLVAHIKVGETYHQRKEGVSRQQWYLFNDFLIEPIEQTEAAQFDVSWKVPAILCYAKRNYHTKYDLRSEFQHNQSEVKSDLYRTQKQSKTDATFIPLTVSEMPQAGDLVGLDAEFVKLSEEEAVLHSDGTKSTITPSQMSVARITCVRGQGPNEGVPFIDDYISTQEQVVDYLTKYSGIEPGDLDATVSSKHVTTLKSTYLKLRFLIDAGVRFVGHGLQNDFRVINLVVPKDQVIDTVHLFRLPYKRMISLKFLAWYFLGLNIQGETHDSTEDSCTALKLYRKYLELYQEGGNHYVMKVLYEVYDKGFQLNWKWTECTLLPSTGAAVLPSVMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DL69</accession>
    <name>A0A3P9DL69_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid binding protein 10b, liver basic</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004569324.1">
        <property type="nucleotide sequence ID" value="XM_004569267.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DL69"/>
    <dbReference type="Ensembl" id="ENSMZET00005036171.1">
        <property type="protein sequence ID" value="ENSMZEP00005034926.1"/>
        <property type="gene ID" value="ENSMZEG00005026124.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464288"/>
    <dbReference type="KEGG" id="mze:101464288"/>
    <dbReference type="CTD" id="795210"/>
    <dbReference type="GeneTree" id="ENSGT00940000164147"/>
    <dbReference type="OrthoDB" id="8501868at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="169" mass="18804" checksum="1F5EDDFEE55EF67C" modified="2019-02-13" version="1">MDEFRLLRPLSGKTIKEITGSLKSPACQPAACDETVTTSSAANMNFNGTWKVYSEENLEEFLKSIGAPQMIIKMRKEVKPVIIIEQNGKDFTCTVKTPACTKVHSFSLGKESEITTVDGRKFKCIVREENGKLIAENDKFTSVREIQGDEMIETITAGSITFTSRSKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMF6</accession>
    <name>A0A3P9DMF6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Circadian associated repressor of transcription a</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMF6"/>
    <dbReference type="Ensembl" id="ENSMZET00005036730.1">
        <property type="protein sequence ID" value="ENSMZEP00005035478.1"/>
        <property type="gene ID" value="ENSMZEG00005026507.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018360"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031373">
        <property type="entry name" value="Ciart"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35441">
        <property type="entry name" value="CIRCADIAN-ASSOCIATED TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35441:SF1">
        <property type="entry name" value="CIRCADIAN-ASSOCIATED TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15673">
        <property type="entry name" value="Ciart"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="372" mass="41140" checksum="C591D2F845D0B05A" modified="2019-02-13" version="1">MNSLGISSKWPSYDSLPSTPSFLLSETEQTEDEAETFSEGEGDSGIGKLPSADEGISLSGSYIGLPPHTNQLRLRSQCDRSEKCSDMTKPPGSAPSPEDHTLSSSVTPGDIAFAQKCADLHRFIHPLLELLHGLKTGRFDRGLTSFQQSVAMDRLQRILGILQKPEMGEKYLQNLLQIEMLLKMWFPREAFTSTNTPNKTTTPRVAARWSQNQLHIPVKKRKLSWPDSTQAGKVPAKHGKHRSCHAAFSLDTISTCWRGSRIEQKTPEEEADEAAGYSCSSEHEFTHRTGTLSRPSYLCSRRAHDNRKHPESSPPSSSCGSPATQDSSVSSTDLAITWRCLSMPARLKAEGGLDYIRIKLGVEPVCDAYKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNM4</accession>
    <name>A0A3P9DNM4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNM4"/>
    <dbReference type="Ensembl" id="ENSMZET00005036999.1">
        <property type="protein sequence ID" value="ENSMZEP00005035736.1"/>
        <property type="gene ID" value="ENSMZEG00005026694.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000176275"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="171" mass="19021" checksum="5C404C0467467D36" modified="2019-02-13" version="1">MAAETGDGAGQWTETEVAELISIWGDNSIQAKLEGSYRNRAVFECIAKEMIGRGHRRTWLQCQRKVKSLRAKFKEAKDINKRSGRGRVTCPFYDELDRILGDKPSCQPIELIDSSIETAEEEPESPGASASPAPSLNSEKGRLTCCSHVWRIKLSTSNVTLNVLYNTCLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQC9</accession>
    <name>A0A3P9DQC9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQC9"/>
    <dbReference type="Ensembl" id="ENSMZET00005037610.1">
        <property type="protein sequence ID" value="ENSMZEP00005036336.1"/>
        <property type="gene ID" value="ENSMZEG00005027104.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01080000257344"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001230">
        <property type="entry name" value="Immunoglobulin kappa variable 8-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="119" mass="12902" checksum="F280D9A166E44AEC" modified="2019-02-13" version="1">MKLLYVFVSVSSESRGQITVTQPGAVSSAVGGTVSIKCTTSQNVYNNNYLAWYQQKDGGVPKRLIHSVNTRDSGIPARFTGSGSNSDFTLTISGVQAEDAAVYYCQSEHNPNSQWVFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DR93</accession>
    <name>A0A3P9DR93_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch like family member 10</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DR93"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037285"/>
    <dbReference type="Ensembl" id="ENSMZET00005038588.1">
        <property type="protein sequence ID" value="ENSMZEP00005037285.1"/>
        <property type="gene ID" value="ENSMZEG00005027791.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154664"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF172">
        <property type="entry name" value="KELCH-LIKE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="574" mass="64605" checksum="B7699349ABABB8AC" modified="2019-02-13" version="1">MSEEGQLPYKSSSVNNELCLEGQFCDAIIKVEDVEFPVHRIILCNCTPYFRALFTHCSDPDKQVFNIPGLSSEMMALIINFAYTGSVSITGENVVELLMAADQFNAMDIVKLCSDFLGEQLCPENCVGIWQFTKVCLSPELRTKTYHYIISNFEQVVLEEEFLHLTVEELADILDREDLNVWETTLYEALTKWISHVPVQRKQHLTALLSKVRLGLMTSDYLKDNVLSSELVEANSECLSMISNAILDIHDLGSRPFMSALYHPLARPRLPHSILLAIGGWSGGEPTNGIEAYDCRANRWVNVTNNLECPRAYHGAAFLNGYVYSVGGFDGVEHFNSVRRFDLTTHAWNEVAPMHSRRCYVSVTVLNGFIYALGGHDGHVRLSSAERYQPEINQWSLIAPMHEQRSHASCTTLNNRIYICGGLNGNECLQTAEYYNPESNQWTMISPMNSRRSGIGVIAYADHVFAVGGFDGNNYLRTAEAYNPHTNTNFGIEVIDDRLFVVGGFNGFTTTSDVEYYTALTNEWYEACDMDIFRTDLSCCVMSGLSNLTEYTFPRDFLPLEDVLKLAMESAEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRR8</accession>
    <name>A0A3P9DRR8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MABP1/WDR62 first WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRR8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036942"/>
    <dbReference type="Ensembl" id="ENSMZET00005038232.1">
        <property type="protein sequence ID" value="ENSMZEP00005036942.1"/>
        <property type="gene ID" value="ENSMZEG00005027534.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164564"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000046">
        <property type="entry name" value="WD repeat-containing protein 62 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055292">
        <property type="entry name" value="MABP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056161">
        <property type="entry name" value="WD40_MABP1-WDR62_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24780">
        <property type="entry name" value="WD40_MABP1-WDR62_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MABP1/WDR62 first WD40" evidence="1">
        <location>
            <begin position="54"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="327" mass="35946" checksum="D4BDE9D3EF08BB1B" modified="2019-02-13" version="1">MAADGTIRSRIRSLLRSPSIKLRRSGTGARHRRELSDKVTLEKVLGITAPGNRALACDPRSGLVAYPAGCVVVLLNPRKNKQHHIFNSSRKAITTLAFSPDGKYVVTGESGHMPAVRVWEVSECIQVCELQEHKYGIACVAFSPNGKYIVSVGYQHDMVVNVWNWKKNVVVASNKVSSKVTAVSFSDDSSYFVTAGNRHVKFWYLDHAKTCKVNATVPLLGRSGLLGELRNNFFSDVACGRGRQAASTFCITSSGLLCEFNDRRLLDKWVELRTSQATCLCVTDDFIFCGCSDGTVRAFSPANLHFLCTLPRPHCLGVDVASMVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRX1</accession>
    <name>A0A3P9DRX1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport protein 46 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT46 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRX1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037515"/>
    <dbReference type="Ensembl" id="ENSMZET00005038824.1">
        <property type="protein sequence ID" value="ENSMZEP00005037515.1"/>
        <property type="gene ID" value="ENSMZEG00005027973.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005544"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048264">
        <property type="term" value="P:determination of ventral identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048793">
        <property type="term" value="P:pronephros development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="340" mass="38265" checksum="97F1799F0545AB3E" modified="2019-02-13" version="1">MERADRDRGGRLLKNQPYDESLDVADAEEVPSVYSPTSRSQPQVISSCPCRKLRLMSAHSSSDEFDEDHGRGKEPGGGRPEEEEEDDDEEDDDDDEDSEDDESEEDSKLHKAPEGLYDPADYANLPVSTDIKELFQYITRYTPESVELEHNLKPFIPDFIPAVGDIDAFLKVPRADGKPDNLGLLVLDEPSVKQSDPTVLSLFLSEETKQHGATEVKKVTSIANPQSNPRAVDSWVESISALHRSKPPASVQYSRPMPDIDSLMQEWPTELEELLDRLQLPSARLNCDLLQYADIVCSLLDIPVYGSRVQSLHLLFSLYLEFRDSQHFTTMSCCDHIRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DS56</accession>
    <name>A0A3P9DS56_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUEL-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DS56"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037600"/>
    <dbReference type="Ensembl" id="ENSMZET00005038910.1">
        <property type="protein sequence ID" value="ENSMZEP00005037600.1"/>
        <property type="gene ID" value="ENSMZEG00005028043.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154285"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22833">
        <property type="entry name" value="Gal_Rha_Lectin_CSL1-2_RBL_SML_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018005554" description="SUEL-type lectin domain-containing protein" evidence="3">
        <location>
            <begin position="39"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="4">
        <location>
            <begin position="139"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="230" mass="25314" checksum="40D8B150E47D2D13" modified="2019-02-13" version="1">MLRVSAASISLTGSPETMLRLSSTLLLAAACLLVSTGAQRVITCGNHVHRLSCETGVIRVQESMYGRRDRDTCSGEKAEEVAINTACSLEGAEDTIRTSCDGKKVCEVTPAIFARDPCNDTFKYIQTTYTCIPAIHLITCEQSMVELQCDQGHVIHVYHADFGRRDPHICSFRREASHMENIKCSNPLAKLCNGKRTCSMRASSGMLGDTCPRMYKYLELTYNCLKSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSI2</accession>
    <name>A0A3P9DSI2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centrosomal protein of 55 kDa</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSI2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037091"/>
    <dbReference type="Ensembl" id="ENSMZET00005038384.1">
        <property type="protein sequence ID" value="ENSMZEP00005037091.1"/>
        <property type="gene ID" value="ENSMZEG00005027638.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047961"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1180">
        <property type="entry name" value="Geminin coiled-coil domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038926">
        <property type="entry name" value="CEP55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022008">
        <property type="entry name" value="EABR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31838">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 55 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31838:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 55 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12180">
        <property type="entry name" value="EABR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSG101 and ALIX binding" evidence="6">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="163"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="399" mass="46940" checksum="32828FCB953AC535" modified="2019-02-13" version="1">MAASKYKRSLKKKLNSELAMVVSSLRKENAYLKRTLAELTHQQSQHNKLVERFLSLEAIRLECTREFRTKHEKTASPSEQLCEKEKRPVDADSTADEQVSTSNEAVAEVQIHLRDALEKNKQWLEYDQQREAYVRAILARMLWLEKQLNEANQARSQQHNEDHSDEKEKISQMQEHYERLLQKAKDELEVLRERVEVTHQNLMITQNWCKEREREVEELKQQLQAERLSRSTQEVQNCPEDEEQQQRDVREVLQGVLDDERRRSGNSELQANLFQRFMLNRHHADQEKIADLERQIQISSQDLEDERQNCSYLKKQMVKVLKALQKGKGHVAKQLKREKPDQSSGETNPPLSQFSRPSLTSSPHSNLMNESFLECPVCQAEYPVSHHRELMNHLEICLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTI1</accession>
    <name>A0A3P9DTI1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTI1"/>
    <dbReference type="Ensembl" id="ENSMZET00005038742.1">
        <property type="protein sequence ID" value="ENSMZEP00005037436.1"/>
        <property type="gene ID" value="ENSMZEG00005027913.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000167339"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001290">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001443">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="443" mass="50384" checksum="4D7AAED21F5D9204" modified="2019-02-13" version="1">MAFIYRRSVLKNLTLTVLFHSSSDQHTDSPSVDMLASSTTSQKQDLPTDEEACEREVDSKDEHKALAVDKCFKPVSELQVTKKMKKQVRKSDMKEIEKSKIACKVCGVWYLNLGSLIKHTWSHLEEPQGGCGVCGEQFESVDELKRHIRIHQKTHDCSYCGKSFFSIVGLNSHISLHTGDRPFKCKICSKTFAYMSGLNVHHWVHVEEKPHKCDICPKSFGLKAQLQAHSKTHTSKDRYVCNICGKSVCDLRSLTRHKFTHSGERPYGCQICGKRFKLSGILKSHEKIHMARERPFLCHVCCKSFLSNCSLMTHMKTHSSERPHVCGVCSKGFVSNGELKAHMRVHTGEAPYGCSECGRFFKRKTYLTNHIRSHLGIKRFVCAICGKACSRQEHLRVHMRTHNGERPYQCTICEKAFTQSHCLKTHMKSHQVEENSVPSPSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DUD7</accession>
    <name>A0A3P9DUD7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DUD7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037872"/>
    <dbReference type="Ensembl" id="ENSMZET00005039220.1">
        <property type="protein sequence ID" value="ENSMZEP00005037872.1"/>
        <property type="gene ID" value="ENSMZEG00005028258.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00460000041731"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59901" checksum="6AD76C33A62D8914" modified="2019-02-13" version="1">IFYLLSKNTSYTPLPAEELELLQAGMGRQTVSLPEDGDHAEVSLLLEETFPKMEYLCGGWLLHKATGGSGRRKLTVIPPETEGYSVKTLKAVSGGGKSTFYIVPLQETLDTSPLPPDSQHFSKMPKKICYQCNEVMPLQMLAVHINTCKGKFSPDETDDEVICPICTKDFPEDEITVHSTQTYLRMFSTLFLLSVEDVLRCLEQQVDTTTEFKLCVDREDLPDRGILQWQRKKAASPTSVLRVVFIGEAGVDTGALRKEFLSDMISGIESRFFEGLENKGKNPKYSLTDLDNENFRTVGEIIAVSLAQGGPSPAFFKEWCYNFLCSGEVDFSCLSKEDYLMMWADEIVSCGYTNQIKMDSKESMIRAIVLHSTTRLIPMLQQLRKGMELYGLVNLMAVNPEACHSLFVPGKILKVSINIIAFYLEKTSETFSNITDGNTGGAGGEKSESLAVHHVLQWMTGQSHVPILPDEKRHFKITCKFDHECKERLGDHSICYPVVSACTCTVTFPVQHLDTYTVFKTIMSAAVKYGGGFHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0K2CIV9</accession>
    <name>A0A0K2CIV9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">NADH-ubiquinone oxidoreductase chain 3</fullName>
            <ecNumber evidence="3 16">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ND3</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="18 19"/>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2015" name="Mitochondrial DNA" volume="1-2" first="0" last="0">
            <title>The complete mitochondrial genome of the Metriaclima zebra.</title>
            <authorList>
                <person name="Chen X."/>
                <person name="Song X.L."/>
                <person name="Chen L.Y."/>
                <person name="Li Y."/>
            </authorList>
            <dbReference type="PubMed" id="26273916"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2015-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Hoefler B.C."/>
                <person name="Straight P.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Mitochondrion membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 16"/>
    <dbReference type="EMBL" id="KT221043">
        <property type="protein sequence ID" value="AKZ87025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KT166981">
        <property type="protein sequence ID" value="AKZ87038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009166321.1">
        <property type="nucleotide sequence ID" value="NC_027944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0K2CIV9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000009"/>
    <dbReference type="Ensembl" id="ENSMZET00005000026.1">
        <property type="protein sequence ID" value="ENSMZEP00005000009.1"/>
        <property type="gene ID" value="ENSMZEG00005000026.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:26037646"/>
    <dbReference type="GeneTree" id="ENSGT00390000011605"/>
    <dbReference type="OrthoDB" id="154075at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Mitochondrion"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1610:FF:000004">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058:SF9">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 16 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 16" id="KW-0520">NAD</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <keyword evidence="12 16" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AKZ87025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AKZ87038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="116" mass="13152" checksum="9A9F81D26CE76E81" modified="2015-11-11" version="1">MNLITTMLIISITLSTILAIVSFWLPQMTPDHEKLSPYECGFDPLGSARLPFSLRFFLVAILFLLFDLEIALLLPLPWGDQLSSPLMTFTWAFAVLMLLTLGLIYEWTQGGLEWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ASH6</accession>
    <name>A0A3P9ASH6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C2 calpain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ASH6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000670"/>
    <dbReference type="Ensembl" id="ENSMZET00005000743.1">
        <property type="protein sequence ID" value="ENSMZEP00005000670.1"/>
        <property type="gene ID" value="ENSMZEG00005000595.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000239188"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
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        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF409">
        <property type="entry name" value="CALPAIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C2 calpain" evidence="2">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="81" mass="9281" checksum="852DAB4A81046011" modified="2019-02-13" version="1">GPGNNEHAVKYQSVARSHAFINLREVCDRFKLPPGEYAIVPSTFELHRKGSFVLTVFTEKEAHTRSRLQGDRVTLHNRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUB3</accession>
    <name>A0A3P9AUB3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cadherin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUB3"/>
    <dbReference type="Ensembl" id="ENSMZET00005001395.1">
        <property type="protein sequence ID" value="ENSMZEP00005001305.1"/>
        <property type="gene ID" value="ENSMZEG00005001087.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164173"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF287">
        <property type="entry name" value="CADHERIN-RELATED NEURONAL RECEPTOR VARIABLE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cadherin N-terminal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="126" mass="14141" checksum="16D6E00E90613D9F" modified="2019-02-13" version="1">LSIYPLHIPKTHPAVIYLFFVLLDFYSETASGQLSYSISEEVNRGTSVGNIAKDLNLDVHELEPRMFQIVSGSKRKYFEVNTKTGVLYVNERIDREKLCGKAVRCNTWGFGASNCLVGFGTRQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AUM3</accession>
    <name>A0A3P9AUM3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AUM3"/>
    <dbReference type="Ensembl" id="ENSMZET00005001465.1">
        <property type="protein sequence ID" value="ENSMZEP00005001376.1"/>
        <property type="gene ID" value="ENSMZEG00005001151.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01080000257344"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001230">
        <property type="entry name" value="Immunoglobulin kappa variable 8-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="126" mass="13883" checksum="E9DC08DDEA8E3F80" modified="2019-02-13" version="1">PQPCPLWYQLLYVFVSVSSESRGQITVTQPGAVSSAVGGSVSIKCTTSQDVYSNYYLAWYQQKDGGVPKRLIYYTSNRVSGIPDRFTGSGSNSDFTLTISGVQAEDAAVYYCQSYHSINSQYVFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVG6</accession>
    <name>A0A3P9AVG6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Envoplakin a</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Desmosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plakin or cytolinker family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539288.1">
        <property type="nucleotide sequence ID" value="XM_004539231.1"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005001412"/>
    <dbReference type="Ensembl" id="ENSMZET00005001502.1">
        <property type="protein sequence ID" value="ENSMZEP00005001412.1"/>
        <property type="gene ID" value="ENSMZEG00005001178.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470845"/>
    <dbReference type="KEGG" id="mze:101470845"/>
    <dbReference type="CTD" id="373136"/>
    <dbReference type="GeneTree" id="ENSGT00940000153578"/>
    <dbReference type="OrthoDB" id="9945740at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000178">
        <property type="entry name" value="Envoplakin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000088">
        <property type="entry name" value="Periplakin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.780:FF:000001">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000002">
        <property type="entry name" value="Plectin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058847">
        <property type="entry name" value="Plectin_PPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055419">
        <property type="entry name" value="Spectrin_PEPL/EVPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF7">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00681">
        <property type="entry name" value="Plectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26346">
        <property type="entry name" value="Plectin_PPL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23160">
        <property type="entry name" value="Spectrin_1st_PEPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Periplakin/Envoplakin N-terminal" evidence="10">
        <location>
            <begin position="37"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Desmoplakin SH3" evidence="9">
        <location>
            <begin position="392"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Periplakin-like plectin repeat" evidence="11">
        <location>
            <begin position="947"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="Periplakin-like plectin repeat" evidence="11">
        <location>
            <begin position="1185"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="domain" description="Periplakin-like plectin repeat" evidence="11">
        <location>
            <begin position="1409"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="190"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="662"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="787"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1251"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1369"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1466"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1517"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="2002" mass="231220" checksum="0307F1B1E2338F5D" modified="2019-02-13" version="1">MFKKKESSKDTKNGTLKVSGKISKSQATDLALLITQMQKDADLVEKNVLRAEELLAVDFENDKKELPYQHQREISDELGEAEGLLKKLFIDVDKAKNLKHPQATDIESDVLHLHERWLKDCTVYRDIYEQIDDVSRMPLIDWGPVLSEKQKLVDVEQFGPSMADLEKQIAAHNIVHKEIDAYNTQLCLASAGSKEKYDALKKQYNNLLDNSKWRRHYLNSLYEYMQSCNKELNFLAEEQNKIKKQDWSDHMLDPPDVRRQYENFKNNSLLSHEAEVNKLQDEGERLVEMKHPASDTIQAQRDDVRNEWQKFLNLCICQETHLDSVEDFKRYQYDSEQLSESLTKLNSTLDPKTLSKKSKTEKLLQLEAEEKDVQKCEQLLADLRKRSTTIAPLKLRRTTPSRAITVESLCDWETGTDSLQRGDKFTLKSNSDVANWNVISTDGKTKKFPGVCFQIPPPDSEAIDKVDLLGQELADIKKRRAALADSLKNNKSEISRAQQLAPVSSAPMDPKVAALSQQLDKLDNDLAKAEESMLSRLRAPLSRSDPAGDLAKRMKEQEQTAQTLQALQQQQQAAQAGMQPLLAKDPNGTSSGLPLKLSAASNKSDNLAALADLYNKKANASLNLEKQIKKVDGLVSGFEKRLSEDGPIPNGPKAIETRAEEIQSQQKSVAAAQNDMKKLSKDLETTEQLCSSLQQDYQEYCPDIQRQKTEVKQLQARYTNVANQLKERESTLLETAGKNQEFQSTCKSLNSFLDNLPTNKISPNDDLSQIAAKKSSQERVMDDLTRKEADMEKVTSLSQDLQELLNEYETNVDTYNSTLEDAGATVPKKPRMPTLSEAIQKEEKSLVNRYAETKAENTQRQKQMGLAKNLISRNEETVQAVAQQQVRSERSAFELDGLVKELEEEKERRTHAETNLRTFKDRFLSLKSRRGVERVEEKEVLKYYRDPKVESDLRALQQTLHEEIMKRTTIQTEVEVTNKKVTTLAETVKSAPPKLVTREVTEFEKDPQLDTEAAKLRDQITKMREEIRMRDGEHIQMKTEVTILQQKRPTIKERVVKKEVVKVEKDPEMLRAVRTFETEISDESKRTKLLNDDIFQTRSQINALERLIPNIAPKIITKEVKKIEQDQDLINESQNIRTSLEEERIENNSLVNELTVLHNRYREVYEWKPRVEVKEIVNEIYRIDPNTEVEIMRLRKEIQDCSKQRSDLERGLTKVTTELNIIQSEKPRIETKEVFQEVVKEERSPENEREIQRLNDQVHNLHSNYDSLQDQLRMLRQERDEWKAEKSKVETQLVTREVIKYEPDPLQEKEFDRLRNNVREETQIRRTIEEMVFDLKNKYIQLERQKPEEKVVLQEVVRLQKDPRQMVEHERLSRNLDEEVTNRRQFELELQQLRTKVEEKERILRESVERQKRIQAESEVREIKLRISQLENAPPPVEENIVVEEVLKVERDPKLERLTSSLRSDMDKETSDILRLQREIRNINIKLEILQKEKSSERTVYKEVVRVEKDQAVEAERDRLREQVSQSKFARQDLEDELRRFNDKIHFLMNSKSATSREETTLIMNRDALQREKEDLTRELRSLDGKRHDISLSFQQQSRLMSERTQMSRQRSIKMESDVMRLERDILDEKDKIHQRDSIIRELIQNLQREESAETRTKETNVSTKITILDPVTGKDMSPYDAYFQGLIDRPQYIHLQELECDWEEITSLGPDGEISLLQDRKSGKQYSIKDALKDGRLTEYDLQQYKQGKIPISEFALLVAGDNKKQSQFNSITPKSTTSLNSAPINLSAAKETYPVAGIIDTDTDTCYTIRNATVSKLIDSTTAQRLLEAQASTGGIIDISNKGRYTVHKAANRALIEDSQIQRLLNAQKAFTGVEDPVTKERLSVGKAVQKGWMPKDTAIRFMEAQHLTGGLVDPDTGHRVSILDAVGSRMIDNTIMRDLETESAYIKDIIDPITKEKINYKQALNRCRKDPNTGLLMLPASSKGSGYSPVYNSTRYARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AY31</accession>
    <name>A0A3P9AY31_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protocadherin 1 gamma 22</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
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        <property type="protein sequence ID" value="ENSMZEP00005002591.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:anatomical structure morphogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="6"/>
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    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
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    <feature type="chain" id="PRO_5018222803" evidence="15">
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        </location>
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            <begin position="676"/>
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        </location>
    </feature>
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            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
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    </feature>
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        </location>
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    <feature type="domain" description="Cadherin" evidence="16">
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            <begin position="555"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYB9</accession>
    <name>A0A3P9AYB9_9CICH</name>
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            <fullName evidence="8">Transmembrane protein 97</fullName>
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        <name type="common">zebra mbuna</name>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
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                <person name="Nikaido M."/>
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                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="gene ID" value="ENSMZEG00005001929.1"/>
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    <dbReference type="KEGG" id="mze:101479750"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="62"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="233" mass="26478" checksum="777CE39F90BF63A3" modified="2019-02-13" version="1">MRILHCGTNGAFRNALMSFSLANGIQPGNRRFNVALLPQRTWTPFLPLCALSKSEIMSLRVLELIFFFYFATHIPITLFIDLQALLPEHVYPQPLKDLLKWYAADFKDPMVLDPPEWFKSFVFCEALLQTPFFPIAAYAFLKGGCKWIRIPAIVYSTHVATTLIPILAHILFYQFPLKPNPGPQTVQERWLLVSIYAPYLLVPVLLLLTMLMSSTYNASSKPGNVSAKAKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0C3</accession>
    <name>A0A3P9B0C3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="RefSeq" id="XP_012775433.1">
        <property type="nucleotide sequence ID" value="XM_012919979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B0C3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003319"/>
    <dbReference type="Ensembl" id="ENSMZET00005003451.1">
        <property type="protein sequence ID" value="ENSMZEP00005003319.1"/>
        <property type="gene ID" value="ENSMZEG00005002547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465092"/>
    <dbReference type="GeneTree" id="ENSGT00940000156306"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="148"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="473"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="522" mass="58696" checksum="8DCC149DA4AF2707" modified="2019-02-13" version="1">MSENKPNDEPKLSTTDRVVKSVPFPPSHRLTAKEVFDSDGKPKVDVLKAHLTKEGRVDEAVALRLIGEGAAILRSEKNLLDIEAPVTVCGDIHGQFFDLMKLFEVGGSPASTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECRIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEITNLDDIRKLDRFKEPPAYGPMCDLLWSDPLEDFGNEKSQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSNDELSTEEELDGQLIYPPKKGATASARKEVIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKEKLQNAIKGFSPQHKITSFEEAKGLDRINERMPPRRDALPSDASLNSLNKALSSETNGTDAKGSTSSGSNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0K3</accession>
    <name>A0A3P9B0K3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Elastin microfibril interfacer 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
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                <person name="MacCallum I."/>
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                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
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                <person name="Ron M."/>
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                <person name="Okada N."/>
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                <person name="Miska E.A."/>
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                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
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                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="PubMed" id="25186727"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549244.1">
        <property type="nucleotide sequence ID" value="XM_004549187.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3G7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004424"/>
    <dbReference type="Ensembl" id="ENSMZET00005004626.1">
        <property type="protein sequence ID" value="ENSMZEP00005004424.1"/>
        <property type="gene ID" value="ENSMZEG00005003435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479048"/>
    <dbReference type="KEGG" id="mze:101479048"/>
    <dbReference type="CTD" id="50484"/>
    <dbReference type="GeneTree" id="ENSGT00390000013305"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000015">
        <property type="entry name" value="Ribonucleotide reductase M2 b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF19">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="349" mass="40534" checksum="FA2CD75155AA6A86" modified="2019-02-13" version="1">MTPTVKKSSSQNGFREDDTACQNGLETEEEPLLRENPRRFVIFPIQYRDIWKMYKQAQASFWTVEEVDLSKDLAHWDRLKAEEKHFISHILAFFAASDGIVNENLVQRFSQEVQVPEARSFYSFQILIETVHSEMYSMLINTYIRDLKERDYLFNAIQTMPCVKRKADWALQWINDSKSTFGERIVAFAAVEGIFFSGSFAAIYWLKKRGLMPGLSYSNELISRDEGLHCNFACLLYSYLVKKPSEERVRDIITKAVSIEQEFLTEALPVDLIGINSCLMKQYIEFVADRLLTDLGLTKVYQAENPFDFMESISLEGKTNFFEKRVAEYQRFGVMSSMMDGEFTLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B486</accession>
    <name>A0A3P9B486_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Cholinephosphotransferase 1</fullName>
            <ecNumber evidence="23">2.7.8.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Diacylglycerol cholinephosphotransferase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54232"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:76979"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74963"/>
            <dbReference type="ChEBI" id="CHEBI:82949"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:54333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-choline = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74965"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:54345"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:32940"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="22">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 27">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="23"/>
    <dbReference type="RefSeq" id="XP_004548402.1">
        <property type="nucleotide sequence ID" value="XM_004548345.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B486"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004592"/>
    <dbReference type="Ensembl" id="ENSMZET00005004795.1">
        <property type="protein sequence ID" value="ENSMZEP00005004592.1"/>
        <property type="gene ID" value="ENSMZEG00005003555.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476120"/>
    <dbReference type="KEGG" id="mze:101476120"/>
    <dbReference type="CTD" id="56994"/>
    <dbReference type="GeneTree" id="ENSGT00950000183117"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000002">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF32">
        <property type="entry name" value="CHOLINEPHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
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            <dbReference type="Ensembl" id="ENSMZEP00005004592.1"/>
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    <sequence length="382" mass="42585" checksum="EBCC2971AE5B5C47" modified="2019-02-13" version="1">MPHFLWPEPLSPAQLKRLEEHKYSASGRSLFEPPCQIYWNWLVQQIPTWIAPNTLTIVGLLVNVLSTLVLVYYCPTATEEAPSWAFILSALGLFIYQSLDAIDGKQARRTNSSSALGELFDHGCDAVSTVFVAVGTCISCGIGQYPNWTFFCGFIGMFMFFCAHWQTYVSGTLRFGLVDVTEVQFAIIIMYVMSAFGGVSLWQYTLPIIGLKLYAFPVMGIIGGALYSCYNYFYVILNGGVGKNGSTVADTSVLSPGLHISLILTLAFIIFKKSSSHLFEHHPCLYLLTFGMVIAKISNKLVMAHMTKSELYLPDPAFIGPGLLFLNQYFNSFIDEHIVLWIAMVLSSVDLIRYCTGVCLQIASHLRIHVFSITTPSQLHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B574</accession>
    <name>A0A3P9B574_9CICH</name>
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        <submittedName>
            <fullName evidence="9">Growth differentiation factor 15</fullName>
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        <name type="scientific">Maylandia zebra</name>
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            <taxon>Actinopterygii</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Cystine-knot cytokines"/>
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        <property type="entry name" value="TGF-b_C"/>
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    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
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    </dbReference>
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        <property type="entry name" value="INHIBINA"/>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
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        <location>
            <begin position="256"/>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51362"/>
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            <dbReference type="Ensembl" id="ENSMZEP00005004932.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="370" mass="41353" checksum="D6DE3DCC5B9F2F90" modified="2019-02-13" version="1">MCISHAILPLVTCTLLLLASTSGEGQLHKAHENTPDMESMDSQAVLLLEAVKTGILSSLGMDVEPRLTQKASKKELREMYQLYRRKIREIRGNSSQPMGENSQSTMSTVLFPVSPVIALRRGSRSGPSMRWYRAVFQKNTNIQNDLTVARAELKISRQVLGKLTSVRPEAREEIKIKVNGGKPAVWPAAWTDSVAQTNISNIQDAYLDIIPEVEKWFKTNGKPLVVDVGVANRGALKPIFSLELDLTQANPAQRTRQRRSNKEDDCAEPGWCCRKSVTVSFEDIGWTDWVVAPVEYTMHFCDGTCPHNYKPASMHTQVKSRLHQITKGGTPHPCCVPAAYEPMVLMHYDSRGKLTLTTFTDFIVSKCYCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5V1</accession>
    <name>A0A3P9B5V1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatase, orphan 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012775499.1">
        <property type="nucleotide sequence ID" value="XM_012920045.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5V1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005172"/>
    <dbReference type="Ensembl" id="ENSMZET00005005398.1">
        <property type="protein sequence ID" value="ENSMZEP00005005172.1"/>
        <property type="gene ID" value="ENSMZEG00005004021.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485115"/>
    <dbReference type="KEGG" id="mze:101485115"/>
    <dbReference type="CTD" id="493911"/>
    <dbReference type="GeneTree" id="ENSGT00390000007741"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF1">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE PHOSPHATASE PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="243" mass="27186" checksum="94CC9846CA9BB50B" modified="2019-02-13" version="1">MKILMVFDFDHTVVDANSDTWVVRCLPDKTLPGSVENSYRKGYWTEYMGRVLNYIGEQKVSPDRVRSVMETIPFTAGMTELLTFIAENKSAIDCIVISDSNTLFIEWILHAAGLQAAVDKVFTNPAKLNELGHIEVQCYHSHACDQCPVNLCKKKVLELYLSLQSDAGVEYEQIFYAGDGGNDLCPTSCLRGRDVVMPRKGYTLEKLLAKLEGQEGNFSVRAKNIAWSSGTDILRELKASMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6J9</accession>
    <name>A0A3P9B6J9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Si:ch211-168f7.5</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dapper family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545607.1">
        <property type="nucleotide sequence ID" value="XM_004545550.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6J9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005515"/>
    <dbReference type="Ensembl" id="ENSMZET00005005746.1">
        <property type="protein sequence ID" value="ENSMZEP00005005515.1"/>
        <property type="gene ID" value="ENSMZEG00005004275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481900"/>
    <dbReference type="KEGG" id="mze:101481900"/>
    <dbReference type="GeneTree" id="ENSGT00950000183181"/>
    <dbReference type="OrthoDB" id="8912465at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900108">
        <property type="term" value="P:negative regulation of nodal signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024843">
        <property type="entry name" value="Dapper"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15919:SF14">
        <property type="entry name" value="DAPPER HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15919">
        <property type="entry name" value="DAPPER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15268">
        <property type="entry name" value="Dapper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="689"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="913"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1084" mass="116752" checksum="D756A918469350CA" modified="2019-02-13" version="1">MAARRGCVNSLWSGTERVRIGERLKATLAGVMELEVLRCKHLEMVDAALEDRPPVAANAEDPRAAEEEEEGRETSESGAMDGEHGSATSRRQQDPSPSDTACQSSPEECGGNSGDGTAHLSSGRGSSSRWSTLSWDAPSDLLSPPTPDLNGMIPLDSDSRPSSGFYSVSGSSLSDSCYSVSSDAAHGGPVAPARPLKLWEQVPACADNTDLLWPEVAVQLQQPVLQDSQEDAEPTEETPVSVPNDLEATGLTFLSELCSGLGDSLISFILPLLNPSSSSSTSCSQNSKLQLDSRYCTDLMSRRTKEVYSYPSPLHAVALQSPLFTTQNQEQSASVSPEGPQHDEPTESNADTALPLQPQQPPTPPSFTQLEQYISRLARQYHCRAKSTSDLTSPATPGPVTHRGLCTPGKTHGSTQSLSAFESRSTPSTQPGVNITPSKSLLGNSARVSLSTTGKKGTRNSINLGNLPSATGEDLNINLHLNLNLNLTPGLNSGHGLVDNPRNGALRRDFAANSTASASSHSSATPTPAMRPRPRISTCPSSLSHRSSLEVPLGSGASSGFGSSAFCRSLDWSSGAPPEAGQPVFGTNAGSAPGSQRSSLIQESNSSPKLSEDSPMVEEISRLSGLSRAVVVGLMEQGVELDIDCFPTDTAGEMRSHTKTHLTAQTDQSHDYTRLTDLNPQRPIQLSLSVTHSPQSQSSLTPPLSHSSSPIHPYQSMHIPSSHYSSHSHYQQTPDLPSSTASSPASRPTPRGRSPPRPLQPSPLGATPLSVFRRDAPFQCSLPRTNTRTSPFEHGGIQPRGGSLRQSSGGGEGNSRQKRAEGDGLYRGKHASHKLIRAATVSSYAKREDYSSVWREEEEKLRAAAHTSNKSSSKLWKGFDGRLWSKESESEREEIDRAEYGYGWRTNSVGSWRREHRRVKASSSGDKRPKVDNSPVFSKKRGKDDGERRSSSLKLSRRALFRSESQGLLVPRNHSEEPTKRPHWVSSLDVGHGGMGIRKDEGVRLLRAKEEDKRLSSTASLFNLSRSQSLEGSCHSLSPLSSPSLSPSPPPRLPLQRSRSLRDLGRKVFGSMRSLSLKQKSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAC9</accession>
    <name>A0A3P9BAC9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="15">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">Clathrin-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Secretory vesicle</location>
            <location evidence="12">Synaptic vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004572565.1">
        <property type="nucleotide sequence ID" value="XM_004572508.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAC9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006849"/>
    <dbReference type="Ensembl" id="ENSMZET00005007151.1">
        <property type="protein sequence ID" value="ENSMZEP00005006849.1"/>
        <property type="gene ID" value="ENSMZEG00005005256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472718"/>
    <dbReference type="KEGG" id="mze:101472718"/>
    <dbReference type="CTD" id="359839"/>
    <dbReference type="GeneTree" id="ENSGT00940000155068"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF5">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B, BRAIN ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="17">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="16">
        <location>
            <begin position="164"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="18">
        <location>
            <begin position="396"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00029434"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00037827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
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            <dbReference type="ARBA" id="ARBA00045731"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
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            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="502" mass="55683" checksum="9CD7E6D02DC2AA05" modified="2019-02-13" version="1">MATLVANRAMDVNGLAAASRTHTQAVTRNYISQPRLTYSTVSGVNGPLVILDNVKFPRYAEIVHLTLPDGTKRSGQVLEVIGTKAVVQVFEGTSGIDAKKTACEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPTVLAEDYLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVQKSKDVMDYSADNFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEYLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQVYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFIAQGPYDNRTVYETLDIGWQLLRIFPKEMLKRIPQSTLAEFYPRESARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCB5</accession>
    <name>A0A3P9BCB5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI domain containing 3A</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005005772.1"/>
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        <property type="component" value="LG11"/>
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        <property type="term" value="C:mitochondrial intermembrane space"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PRELI/MSF1_dom"/>
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        <property type="entry name" value="Slowmo/Ups"/>
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    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRELI_MSF1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="178" mass="20308" checksum="D75EC857DF3F3295" modified="2019-02-13" version="1">MKIWSTEHVFSYPWETVIKAAMRKYPNPMNPNVIGVDVLDRSLDTEGRLHSHRLLSTEWGLPAIVRAILGTNQTQTYVKEHSIVDPEEKKMELCSTNITLTNLISVDERLLYRPHPENPEVTVLTQEAIITVKGVSLGSYLEAMMARSMSANARKGWDAIEWIIQNSERENVPLCDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD29</accession>
    <name>A0A3P9BD29_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Lipid-anchor</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547279.1">
        <property type="nucleotide sequence ID" value="XM_004547222.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD29"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007787"/>
    <dbReference type="Ensembl" id="ENSMZET00005008105.1">
        <property type="protein sequence ID" value="ENSMZEP00005007787.1"/>
        <property type="gene ID" value="ENSMZEG00005005927.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475526"/>
    <dbReference type="KEGG" id="mze:101475526"/>
    <dbReference type="CTD" id="115827"/>
    <dbReference type="GeneTree" id="ENSGT00940000157368"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="242" mass="27126" checksum="967BA0DCF6FB9E4B" modified="2019-02-13" version="1">MQERAVKQIFGEKKTDNRMDLYGKMAATQDAKGKGEGGENFDYMFKLLIIGNSSVGKTSFLFRYADDAFTSAFVSTVGIDFKVKTVYKNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFGAVQDWSTQIKTYSWDNAQVVLAGNKCDMEEERVVSVDNGRLLAEQLGFEFFETSAKDNINVKQTFERLVDLICDKMSESLDADPAVTTGAPTAKLTDSAPPLQQPGCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BD84</accession>
    <name>A0A3P9BD84_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-protein coupled receptor 22</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BD84"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007838"/>
    <dbReference type="Ensembl" id="ENSMZET00005008156.1">
        <property type="protein sequence ID" value="ENSMZEP00005007838.1"/>
        <property type="gene ID" value="ENSMZEG00005005980.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278263"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000084">
        <property type="entry name" value="Probable G-protein coupled receptor 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000116">
        <property type="entry name" value="probable G-protein coupled receptor 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="434" mass="48553" checksum="CDAD514FE6CA11E5" modified="2019-02-13" version="1">MCPEKEATMSNVTVTDNTEPISGTMSPATPSLYPVSFQVSLTGFLMLEILLGLSSNLTVLALYCMKSNLISSVSNIVTMNLHVLDVLVCVCCIPLTIVVVLLSLEGDTALVCCFHEACVSFASVATAANVLAITLDRYDISVKPANRVLTMGRALALLATIWVLSFVSFLVPFIEVGFFAQGHTEQNQTLVENVVPTNQYYNELGLYYHLLAQIPIFFFTAIVMLITYSKILQALNIRIGTRFHASQKKKARRKKRLSMTTMTTQQETTDGSQSSGTRNPTLGMRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIVSTFLLCWTPITVLNTVILSVGLSDLMVKLRLGFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIIEADPTPNNAIIHNSWIDPKRNKKVTFEDKDAQLKCLSSENVDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDJ9</accession>
    <name>A0A3P9BDJ9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="RefSeq" id="XP_014264179.1">
        <property type="nucleotide sequence ID" value="XM_014408693.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDJ9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007948"/>
    <dbReference type="Ensembl" id="ENSMZET00005008269.1">
        <property type="protein sequence ID" value="ENSMZEP00005007948.1"/>
        <property type="gene ID" value="ENSMZEG00005006058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475872"/>
    <dbReference type="KEGG" id="mze:101475872"/>
    <dbReference type="GeneTree" id="ENSGT00940000165995"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000002">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF29">
        <property type="entry name" value="AMINOACYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="184" mass="20250" checksum="C8C342936CA468F0" modified="2019-02-13" version="1">MEPSEQSGPDSGSQDVNPVFLQQLRELDIPEEAAKQALLHTRNVSAEEAAMYYFNKLENEEEGDDDLIYKMVFVVNMDLAMGIGKVAAQVGHAAVGLYQALQEKNSWREMAWRWDHSGAKKVVVQGTNVAHLLELQALAMSLSLPTYLVQDAGLTQVESGSRTVLAIMGEEEMVNNVTGSLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDK2</accession>
    <name>A0A3P9BDK2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 19 member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDK2"/>
    <dbReference type="Ensembl" id="ENSMZET00005008144.1">
        <property type="protein sequence ID" value="ENSMZEP00005007826.1"/>
        <property type="gene ID" value="ENSMZEG00005005947.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183022"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090482">
        <property type="term" value="F:vitamin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000225">
        <property type="entry name" value="Solute carrier family 19 member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002666">
        <property type="entry name" value="Folate_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00806">
        <property type="entry name" value="rfc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686">
        <property type="entry name" value="FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10686:SF37">
        <property type="entry name" value="THIAMINE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01770">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028739">
        <property type="entry name" value="Folate_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="462" mass="52117" checksum="9E16C15A03631EB8" modified="2019-02-13" version="1">MEAVKKWRSDWKYPTILLCIYGFFSTVRPLEPFLIPYLTGPDKNLTTEQVNNQIFPVWTYSYLSVLVPVFLLTDWLRYMPVVVFQCVMIFITQALLLWTASVPAMQAMQFFCGVATASDVAYFSYIYSVIDLKRYRKATSYSRSVQLLGYTVGSVLGQLLVSFDLMSYNNILVFTLVLTAIALLTSFFLPVPQKSMFFHQRRGRQTAAEQSNAINASLEDGGGEMVESGEGEPDAEKLESIITQSCGQVLLQLWRDFRHCYSSRQLLYWSVWWAMATCGYNQTVNYVQVLWEHVQPSQNFSIYNGGVEAVSNLLSAATAYGIGFTEVRWEQWGELALGGFSGLSAASLFLMTFTGNIWVCYSGYVVFKSLYMTLITIAMYQIAADLSMERYALVFGANTFGALALQTIITSVVVDSRGLGLAIIPQFTVYSSYFLVISVVFLLRGLLVSTKKQKRDNSSRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BE26</accession>
    <name>A0A3P9BE26_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BE26"/>
    <dbReference type="Ensembl" id="ENSMZET00005008458.1">
        <property type="protein sequence ID" value="ENSMZEP00005008133.1"/>
        <property type="gene ID" value="ENSMZEG00005006173.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14296" checksum="F333B614283D745A" modified="2025-10-08" version="2">MRLWTGSQTYFLAVVFCVFLFQPKLPSDWSALCFFKLGAVNVAAIRRWWLWEVSVCLRTAGGRRQCKIEIQDEQQGQQEGRVGKVSQDALCSTFSGFLSVNLYRTTNIGTQLVKLQSIFNRFFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BE63</accession>
    <name>A0A3P9BE63_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nucleotide triphosphate diphosphatase NUDT15</fullName>
            <ecNumber evidence="10">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">MutT homolog 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Nucleoside diphosphate-linked moiety X motif 15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Nucleoside diphosphate-linked to another moiety X hydrolase 15</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives. Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear. Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs. May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67592"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="Rhea" id="RHEA-COMP:17276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
            <dbReference type="ChEBI" id="CHEBI:172371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:67593"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Interacts with PCNA; interaction is disrupted in response to UV irradiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="10"/>
    <dbReference type="RefSeq" id="XP_004552597.1">
        <property type="nucleotide sequence ID" value="XM_004552540.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BE63"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008199"/>
    <dbReference type="Ensembl" id="ENSMZET00005008526.1">
        <property type="protein sequence ID" value="ENSMZEP00005008199.1"/>
        <property type="gene ID" value="ENSMZEG00005006240.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474582"/>
    <dbReference type="KEGG" id="mze:101474582"/>
    <dbReference type="CTD" id="55270"/>
    <dbReference type="GeneTree" id="ENSGT00390000003338"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000034">
        <property type="entry name" value="Nucleotide triphosphate diphosphatase NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="19">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="150" mass="16903" checksum="19468DED0E26D5AD" modified="2019-02-13" version="1">MPNNVVKRPGVGVGVLVTDSAHPGCVLLGKRKSAVGKGTYQLPGGHLEFGETWEECAHREVLEEAGVGLVNTHFASVVNAIKLEEQYHYVTIFMQGELDRQSGEPQNLEPDKNEGWTWTRWDDFPPEQQLFMPLARLRQQGFQPFRNKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEU5</accession>
    <name>A0A3P9BEU5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein phosphatase 1 regulatory subunit 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein phosphatase inhibitor 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with PPP1R15A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein phosphatase inhibitor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547788.1">
        <property type="nucleotide sequence ID" value="XM_004547731.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEU5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008412"/>
    <dbReference type="Ensembl" id="ENSMZET00005008748.1">
        <property type="protein sequence ID" value="ENSMZEP00005008412.1"/>
        <property type="gene ID" value="ENSMZEG00005006416.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483072"/>
    <dbReference type="KEGG" id="mze:101483072"/>
    <dbReference type="GeneTree" id="ENSGT00940000161232"/>
    <dbReference type="OrthoDB" id="9940275at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008466">
        <property type="entry name" value="PPP1R1A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15417:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15417">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05395">
        <property type="entry name" value="DARPP-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="208" mass="23066" checksum="023D2CBE52E996DC" modified="2019-02-13" version="1">METGSPRKIQFTVPLLDTHLDPEAAEQIRRRRPTPATLVASSDQSSPEIDEDRLPNQLYKAALLNSPRQRRKGQKGTPTMKELQFLVEHHLYRQQQGAGDECSSESCLSDRPSPDSVPTGEELPHDDEATAEAFEKLRCQMEEFSRESLLEAAGGLECPLTKEKEDCFSVASVADPLSQQNNAQAETKAGVSQPAEEKTKKCSLKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGA0</accession>
    <name>A0A3P9BGA0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol-specific phospholipase C, X domain containing 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004547245.1">
        <property type="nucleotide sequence ID" value="XM_004547188.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGA0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008949"/>
    <dbReference type="Ensembl" id="ENSMZET00005009293.1">
        <property type="protein sequence ID" value="ENSMZEP00005008949.1"/>
        <property type="gene ID" value="ENSMZEG00005006776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466599"/>
    <dbReference type="KEGG" id="mze:101466599"/>
    <dbReference type="CTD" id="345557"/>
    <dbReference type="GeneTree" id="ENSGT00940000158747"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08616">
        <property type="entry name" value="PI-PLCXD1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000021">
        <property type="entry name" value="PI-PLC X domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042158">
        <property type="entry name" value="PLCXD1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF33">
        <property type="entry name" value="PI-PLC X DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="5">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="322" mass="36588" checksum="CFC79F9A266628F9" modified="2019-02-13" version="1">MASSHGRSDLRFADWMASLPQSMHTIPLTNLAIPGSHDSFSFYIDEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMNFTSQLEAGIRFFDLRISTKPRDPENELYFAHGLFSATVREGLEQISSFLSAHAREVVFLDFNHFYGMQNLHHEKLVTMLKEVFGEKLCPVVFAQEVSLQYLWEKEYQVLVFYHHPMALEVPFLWPGQMMPSPWANTTDPEKLIQFLQASITDRRRKGTFFVSQVVLTPKASTVMKGVASGLRETITERALPGMMQWIRSQRPGESGINIITADFVELGEFISAVITLNYHLDDEDDDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BH93</accession>
    <name>A0A3P9BH93_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:12706"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="6"/>
    <dbReference type="RefSeq" id="XP_004540585.1">
        <property type="nucleotide sequence ID" value="XM_004540528.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BH93"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009126"/>
    <dbReference type="Ensembl" id="ENSMZET00005009475.1">
        <property type="protein sequence ID" value="ENSMZEP00005009126.1"/>
        <property type="gene ID" value="ENSMZEG00005006920.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477411"/>
    <dbReference type="CTD" id="393741"/>
    <dbReference type="GeneTree" id="ENSGT00950000183032"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000027">
        <property type="entry name" value="Protein-L-isoaspartate O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF19">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018116600" description="Protein-L-isoaspartate O-methyltransferase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="249" mass="26633" checksum="DD13438385E390EC" modified="2019-02-13" version="1">MRAALRLAVVAVPMGVLLSRTMAWMSSGKTNPELISRLRDHGVIQSDRVFNAMLATDRGLYSRDYPYADSPQSIGYRATISAPHMHAHALELLSDKLTEGASALDVGSGSGYLTACFARMTGPTGRVVGIEHIDELVQMSIKNVQADDPELLSSGRIKLVVGDGRLGYPDGAPYDAIHVGAAAATVPKALLEQLKPGGRLVLPVGPDGGSQVLEQYDRQSDGSFLKKALMGVVYVPLTDKRHQWPGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHR2</accession>
    <name>A0A3P9BHR2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BHR2"/>
    <dbReference type="Ensembl" id="ENSMZET00005009822.1">
        <property type="protein sequence ID" value="ENSMZEP00005009464.1"/>
        <property type="gene ID" value="ENSMZEG00005007176.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000204328"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="91" mass="10837" checksum="ACA973C25AE185CE" modified="2019-02-13" version="1">TEDFHEEEEYVKSLIKNFDHAEGWTWIGLSDLHKEGRWMWSDGCSFFLLTLNRPATITSFICVHCNKKCAQGLFWICLLRMIAHFYFLFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIF7</accession>
    <name>A0A3P9BIF7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Hyperpolarization activated cyclic nucleotide gated potassium channel 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="26 27">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel HCN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539698.1">
        <property type="nucleotide sequence ID" value="XM_004539641.3"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005009714"/>
    <dbReference type="Ensembl" id="ENSMZET00005010074.1">
        <property type="protein sequence ID" value="ENSMZEP00005009714.1"/>
        <property type="gene ID" value="ENSMZEG00005007346.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466081"/>
    <dbReference type="KEGG" id="mze:101466081"/>
    <dbReference type="CTD" id="10021"/>
    <dbReference type="GeneTree" id="ENSGT00940000154743"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000031">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000002">
        <property type="entry name" value="Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000007">
        <property type="entry name" value="Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF4">
        <property type="entry name" value="POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0114">cAMP</keyword>
    <keyword evidence="7" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="19" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="25">
        <location>
            <begin position="564"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="837"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1094"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1165"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1286"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1383"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1165"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="1178"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1207"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1294"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1425"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006305"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1438" mass="153558" checksum="B38E3E9D2A47DDC6" modified="2019-02-13" version="1">MDRLHSSMRKRLYSLPQHIGQKASIMGEGEDADKDTRRKSIRMKPLPSPSPTSGGSCKGIGETKSGESVIMETDIGRPMKTSSNGDCRRFRGSLSSITSRHVHDSDSAEERRLITEGDVTPSEESPPGAIGDGQPDQGAQEASSGAGGGAQNDSPDQQSGFIKLDGIDQILPDDERLYQAGFIHRQLGAMLQPGVNKFSLRMFGSEKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDEHTPPWIVFNVVSDTFFLMDLVLNFRTGIVKEDNTEIILDPQQIKIKYLRSWFVVDFISSIPVDYIFLIVETRIDSDFYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAMVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPADCWVSKNKMVNDTWGQQYSYALFKAMSHMLCIGYGMYPPVGMTDVWLTILSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQRIHDYYEHRYQGKMFDEESILGELNEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILQHKVQHDLSSGVLNYQENEIIQQIVQHDRDMAHCAHLMQNAPPQTPPSPTPVIWAPLIQAPLQAAAATTSVAIALTHHPHLPSTLFRPPVSVLGSLKDPPSRLKKFHTFVPSSTSPGSAGDSPSSTPSKLQTGIDMPLLASFRAQQITSGSGATSSSQHASGSGIQRGPCRSGPVSSGGATSVFPFGQFSSSGSPSSSTAQLHPQPQNQKSFRSGTPPLSNLFHQGSIGGSTGSGLSGSLAGACGGATGWTLGGAVGGFVEGATGGDTSWAGEDYTTGLLEVTSGGHSGLGGANGGSVEGISGETKVGVSEGAVETVCSRLSGGLVVPNTCGPITDTAKRSIGGTSRGSLVIASGGSVSGTSGESLAVTTTGGSLGRASDGSVGLVYGGASGGTFGGFSCDSTQGNSGGSMGRTSGGSTTSHLGGGSSGTVGGVTGGHIGRAVSGTIGSHIAGSTACSLGGITSGLISSSRCQSPISNNSLSGQLPQNQPPAKPPQVAPLQQFAGGGRTTSGLNLFQSPPQGSPSSGRGQHSQQPAEGSPSSLSHSSLAGLQSGCLPHQMSLERSALASLAQYGSANASPCLTPVAPSPTVQSPVAGRTFHYSDPSSVTGSHSSLLMPQTCFPSQLPSQPQSTGRDSPLGRFSEDLKLLSSSHSSLPQEVAQVLSHQTPCSSIETGYYPSPFSSPTLVPKPCSSVPGHMTPPIQMSPGHPHQTYSSGASPALSLRRDSAAFSSDLEPQSVRSKLPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BII6</accession>
    <name>A0A3P9BII6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BII6"/>
    <dbReference type="Ensembl" id="ENSMZET00005010101.1">
        <property type="protein sequence ID" value="ENSMZEP00005009740.1"/>
        <property type="gene ID" value="ENSMZEG00005007369.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00980000199528"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="165" mass="18615" checksum="9047A8CB04405E94" modified="2019-02-13" version="1">VLSVTPKLLEALVFIFSAKGSGLGSRSHLSSAHHYSCYMHNAVTMTWADAELHCVSEGTNLVSIHGENVFTWIGLGDIHKEGRWMWSDGSQVSFELWGQGKETCAHINFGPDVIWNDLDSYFPLFTFTFICGYYVSKRSFYVDICYLMLLFFVTVNEGKAFAECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BIM7</accession>
    <name>A0A3P9BIM7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Endonuclease III-like protein 1</fullName>
            <ecNumber evidence="14">3.2.2.-</ecNumber>
            <ecNumber evidence="14">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="14">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NTHL1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="14"/>
    <dbReference type="EC" id="4.2.99.18" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BIM7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009743"/>
    <dbReference type="Ensembl" id="ENSMZET00005010103.1">
        <property type="protein sequence ID" value="ENSMZEP00005009743.1"/>
        <property type="gene ID" value="ENSMZEG00005007375.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047513"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="121"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="305" mass="34629" checksum="45981CD76B0ADA8A" modified="2019-02-13" version="1">LIHGLNSGFSPVSTRLKTQVRSKGRELLHEAPVQPKTEALTEYPHSRRRRQLKVEYEKDERVSPMKTERWEPADWRKQLGFIREMRSGRDAPVDNMGAEKCYDMEAPAHVRRFQVLVSLMLSSQTKDQVTAAAMQKLRAHGCTVENILATDDEKLGKLIYPVGFWRNKVKYLKLTSAMLQKEFGGDIPSSVEGLVRLPGVGPKMAHLAMDIAWDQVSGIGVDTHVHRISNRLGWLRKATKNPEETRKALEEWLPRELWSEINWLLVGFGQQVCLPVNPLCSVCLNQHSCPSGINVKNRETACLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BN10</accession>
    <name>A0A3P9BN10_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyacyl-CoA dehydrogenase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BN10"/>
    <dbReference type="Ensembl" id="ENSMZET00005011719.1">
        <property type="protein sequence ID" value="ENSMZEP00005011325.1"/>
        <property type="gene ID" value="ENSMZEG00005008503.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177105"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="5767" checksum="311E85DD2CA8087A" modified="2019-02-13" version="1">LQLSVMEPSVGIGAAVAVELVRLGMKVVGCDRDVGKLQVCSEITNLISEEKHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BPN7</accession>
    <name>A0A3P9BPN7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cysteine dioxygenase</fullName>
            <ecNumber evidence="13">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:20442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="13"/>
    <dbReference type="RefSeq" id="XP_004547148.1">
        <property type="nucleotide sequence ID" value="XM_004547091.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BPN7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011897"/>
    <dbReference type="Ensembl" id="ENSMZET00005012305.1">
        <property type="protein sequence ID" value="ENSMZEP00005011897.1"/>
        <property type="gene ID" value="ENSMZEG00005008922.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466957"/>
    <dbReference type="KEGG" id="mze:101466957"/>
    <dbReference type="CTD" id="1036"/>
    <dbReference type="GeneTree" id="ENSGT00390000018226"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="UniPathway" id="UPA00012">
        <property type="reaction ID" value="UER00537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042412">
        <property type="term" value="P:taurine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000045">
        <property type="entry name" value="Cysteine dioxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
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        <property type="entry name" value="RmlC-like cupins"/>
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    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
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    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        </ligand>
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            <position position="141"/>
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        <ligand>
            <name>Fe cation</name>
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    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366010"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011897.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="201" mass="23473" checksum="C97D7B3EAEA34E35" modified="2019-02-13" version="1">MEQTEVVKPETLDDLIKILHSIFESDCINVEEVQNLMESYESNPQEWMKYAKFDQYRYTRNLVDKGNGKFNLMVLCWGEGHGSSIHDHTESHCFMKLLQGQLKETLFEWPESKSHGDMVQKSQRILQENKVAYINDSIGLHRVENVSHTECAVSLHLYSPPFETCQTFDQRTGHKNSVKMTFWSKYGERTPFETTVSQENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWG5</accession>
    <name>A0A3P9BWG5_9CICH</name>
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        <submittedName>
            <fullName evidence="7">Ring finger protein 38</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
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            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
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                <person name="Swofford R."/>
                <person name="Tan F.J."/>
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                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005010694.1"/>
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        <property type="component" value="LG6"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF38"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="693"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="73"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWZ3</accession>
    <name>A0A3P9BWZ3_9CICH</name>
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        <recommendedName>
            <fullName evidence="13">LIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004555642.1">
        <property type="nucleotide sequence ID" value="XM_004555585.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9BWZ3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014510"/>
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        <property type="protein sequence ID" value="ENSMZEP00005014510.1"/>
        <property type="gene ID" value="ENSMZEG00005010880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469398"/>
    <dbReference type="KEGG" id="mze:101469398"/>
    <dbReference type="GeneTree" id="ENSGT00940000153518"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
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        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:focal adhesion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:actin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:cell-cell junction organization"/>
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        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09331">
        <property type="entry name" value="LIM1_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09332">
        <property type="entry name" value="LIM2_PINCH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LIM3_PINCH"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd09334">
        <property type="entry name" value="LIM4_PINCH"/>
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        <property type="entry name" value="LIM5_PINCH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000019">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000062">
        <property type="entry name" value="LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="LIMS1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
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        <property type="entry name" value="PINCH-1/2-like"/>
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        <property type="entry name" value="Znf_LIM"/>
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    <dbReference type="PANTHER" id="PTHR24210:SF12">
        <property type="entry name" value="LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038003">
        <property type="entry name" value="PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13 14" id="KW-0440">LIM domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="142"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="262"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="322"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00055791"/>
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        <source>
            <dbReference type="PIRNR" id="PIRNR038003"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="405" mass="46483" checksum="BB03A18C7B795218" modified="2019-02-13" version="1">MDMNGRGMPPSIPEDEAVHHSPHSEMNGYHQRLQGGGGDGAEDEVPVSKSQRRKSDVKVYKEFCDFYARYNMANALANAMCERCKSGFDPVEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPDCFCCDICQAVLADVGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIEEQPLLFKNDPYHPDHFNCNNCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCYHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKDKFVEVDLKPVCKHCYERLPDDMKRRLAKRERDSKEKKKKLIPMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXA3</accession>
    <name>A0A3P9BXA3_9CICH</name>
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        <submittedName>
            <fullName evidence="3">Glutathione S-transferase rho</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004547840.1">
        <property type="nucleotide sequence ID" value="XM_004547783.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXA3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014613"/>
    <dbReference type="Ensembl" id="ENSMZET00005015096.1">
        <property type="protein sequence ID" value="ENSMZEP00005014613.1"/>
        <property type="gene ID" value="ENSMZEG00005010994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475427"/>
    <dbReference type="KEGG" id="mze:101475427"/>
    <dbReference type="GeneTree" id="ENSGT00510000049601"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glutathione S-transferase rho"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glutathione S-transferase rho"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin-like"/>
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        <property type="entry name" value="GST_NTER"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="98"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="230" mass="26226" checksum="B58172DE1B6F7384" modified="2019-02-13" version="1">MAKDMTLWWGSGSPPCWRVLIALEEKNLQGYNQKLLSFEKGEHKSKEVMDVNPRGQLPAFKFGDIVINESYGACFFLESKFKSQGTKLIPDCAGSDNNCALIALIMQRVFEGNTLHQKMADVFMYNRRVPENERHESAFKRLKETLTTELQMWEGHLKKTPGGFLAGENFSMADVIVFPSVALLLRMGLSEDKYPKLAEYYKKLQGRPSVKATWPPTWKETPGQELLKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXZ5</accession>
    <name>A0A3P9BXZ5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pleckstrin 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540023.1">
        <property type="nucleotide sequence ID" value="XM_004539966.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXZ5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014732"/>
    <dbReference type="Ensembl" id="ENSMZET00005015217.1">
        <property type="protein sequence ID" value="ENSMZEP00005014732.1"/>
        <property type="gene ID" value="ENSMZEG00005011090.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479373"/>
    <dbReference type="KEGG" id="mze:101479373"/>
    <dbReference type="CTD" id="26499"/>
    <dbReference type="GeneTree" id="ENSGT00940000157229"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000208">
        <property type="entry name" value="Pleckstrin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000243">
        <property type="entry name" value="Pleckstrin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEP_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="Pleckstrin"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF2">
        <property type="entry name" value="PLECKSTRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="252"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="358" mass="40286" checksum="78ED1CDB5F505761" modified="2019-02-13" version="1">MDTDKQVNILREGFLVKRGHVVQNWKARWFVLTPDKLLYYKYEGSKRDSCQRGKILLKDCVITCPFLEYENRPLVMKLQTKHGVDHYLEACSREARDEWAADINAAVNNLQTTNGKSKTDKPDPAESQLNNISLSKVLDSMYDVHSGIKLSNHVEQGSTYSNCFSGSAVVDWLVFMQLVLTRVEAVTLASALLEEGFLRTVGQKSVEALRTAGLSAQFMDDSTALYSFSDSLKKRGSVKAETSLSAVELSGKVIKRGYLLKQGHRRKNWKVRLFVLRSEPAFLHYYDPTKDDISPVGGFSLRGCLVSSLEDNGVPSGVKGNVQGNLFKIITQTDTHYFIQAPTHQEKMDWLDAMRSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0P7</accession>
    <name>A0A3P9C0P7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family with sequence similarity 113</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0P7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015667"/>
    <dbReference type="Ensembl" id="ENSMZET00005016172.1">
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        <property type="gene ID" value="ENSMZEG00005011761.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002231"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469:SF0">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="315" mass="36655" checksum="38CEDBC1D45F2D36" modified="2019-02-13" version="1">MREIMKSVSHLQASQLLHNKFMVVLGDSIQRAVYKDLVLLVQKEKYLSLRQLRSKGEMSFEQDCLVEGGCLGQMHNGTEYKEVRQFQSAHHLVRFYLVTRIYSRYMKSILEDFRHGLKPDVVFVNSCVWDISRYSCSWVDDYKENLHRFFDELREALPEETLVVWNLTMPLGERIKGGFLVPEIEHKAPQLRYDVIEANFYSGTLADVYGMDVLDLHFQFRFSLHHRMKDRVHWNAVAHRKITSLLLQHAAEAWGVILPCPVILPCPVTVYGERKSGVARTCRKIFCTSRIKCGLLVSKLSAGFELHLFSPLFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0V4</accession>
    <name>A0A3P9C0V4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        </location>
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    </evidence>
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        <source>
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</entry>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
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                <person name="Gaffney L."/>
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                <person name="Jaffe D.B."/>
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                <person name="Venkatesh B."/>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the FAX family.</text>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <source>
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</entry>
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                <person name="Ron M."/>
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                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Streelman J.T."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004556891.1">
        <property type="nucleotide sequence ID" value="XM_004556834.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C1I3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016120"/>
    <dbReference type="Ensembl" id="ENSMZET00005016635.1">
        <property type="protein sequence ID" value="ENSMZEP00005016120.1"/>
        <property type="gene ID" value="ENSMZEG00005012105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485920"/>
    <dbReference type="KEGG" id="mze:101485920"/>
    <dbReference type="CTD" id="285598"/>
    <dbReference type="GeneTree" id="ENSGT00940000160017"/>
    <dbReference type="OrthoDB" id="413813at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053254">
        <property type="entry name" value="Arf-like_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46724:SF1">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR LIKE GTPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46724">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="223" mass="24736" checksum="C14CDE8FA673D387" modified="2019-02-13" version="1">MVLLRHISIALTAAVAALGSALFIALNYFYKRRLWSPQAEYCTIKEEEEERGKRQVLVLGLDGAGKSSMLQGLTPGDSGAKRGRCRPTRGFNFMSLNAPACQLDFLEIGGGEDLRRYWSDYLRRTHVLVYVVDSSDRSRLPLAKAELHRLLRVEPQLPVVVLGNKQDKPNAVSVSELHEALSLGSVTEDRKLFLLAAQLDSDGALRKSCKCLDAVQDLLLQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C1S2</accession>
    <name>A0A3P9C1S2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C1S2"/>
    <dbReference type="Ensembl" id="ENSMZET00005016715.1">
        <property type="protein sequence ID" value="ENSMZEP00005016200.1"/>
        <property type="gene ID" value="ENSMZEG00005012166.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183052"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001325">
        <property type="entry name" value="zinc finger protein 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001450">
        <property type="entry name" value="zinc finger protein 774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="299" mass="33934" checksum="570418B2229BF191" modified="2019-02-13" version="1">MHVRLHTGEKPYSCNFCGKKFSQKGNLTSHLRVHAEEKAFKCKECSRAFCHMSSLERHMEEHRSSAVHTCSVCGEEFSKRNSLRQHMATHQKNDSLRIKTNRTSIPSFRCKVCSDTFDRKTLLVKHVATHLQDTDCRCGLCGHHYESSDSLAAHLRSHREAGGTCSICGKCFPGQSALQMHLRIHTGEKPYSCSFCGKAFNQSGNLKTHLKIHTGERAFSCSLCGKGFTQKQTLDTHVRFHNKERRFLCQVCGKGFMQDVDLKRHMLIHTGEKPYACRVCGKKTTHGVPIFLSPLLYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4U1</accession>
    <name>A0A3P9C4U1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <sequence length="1023" mass="115566" checksum="8D23229502C48CCC" modified="2019-02-13" version="1">TLISPTIPILLRCIHINGPPCTFNLLQLIVGPSIVLHSVNDCFTLGGKSQTLVSFCSEMFAPLCQCKLKSTLNKKFQCVFEGITKAGNSTLLNQIYTELYITEGGTAEVNDEHEVRQIETTSRKADKPNTTIRLEDIFKTLPGIDEPIRTVLTKGVAGIGKTVLTQKFTLDWAEEKSNQDIQFIFPFTFKELNVLKEEKFSLVELVHHFFTETKEAGICSFEDFQVLFIFDGLDECRLPLDFHKTKILTDSRKSTSVDVLLTNLIRGNLLSSAHIWITTRPAAANQIPPECVDMVTEVRGFTDPQKEEYFRKRFRDKKQASRIISHIKTSRSLHIMCHIPVFCWINATVLEDVLKTKEQRDMPKTLTELYIHFLVVQAKVKKVKYDGGSETDPHWSPESRKMVECLGKLAFEQLQKGNLIFYETDLTECGIDVRAASVYSGVFTQIFKEERGLYQDKVFCFVHLSIQEFLAALHVHLTFFNFCVNLLEGETSAWSKAFNKLKLQNCGGQFLHKSAVDKALESPNGHLDLFLRFLLGLSLQSNQALLRGLLTQTGMSSETNQQTVQYIKKKISENLSVEQSINLFHCLNELHDRALVGELQQSLSMGSLSTEKLSPAQWSALVFILLTSEKDLDVLDLKKYSASEDALLRLLPVLKASKKALLNNCNLTERSCEALSLSLKVEGCELRTLDLSNNNLQDSGVNLLIAGMESMHCKLEKLRSDTLFKSCGTMSSVLSLQFSSLREMDLSNNNLRDTGVKALSDGLRSPHCKLETLRLSGCLITEEGCTLLASDLRSNPSCLRELDLSYNHPGETGMNLLKQLRLDNLRYRERLIASHTFEHRRLIRRKNSCQLTIDTNTVHRKLKLSDNMKVRKAKEVQSYPDHPDRFERPQLLCKDGLTGCCYWEVEWNGKVEISVSYRGITRRRDNDCLFGWSDQSWSLSCCDDGRYSAWHNKKSTSISSSSSSVSNRVAVYVDCPAGTLSFYRVSSDTLIHLHTFNTTFTEPLYPGFGIWSSGSSVTLCSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6L7</accession>
    <name>A0A3P9C6L7_9CICH</name>
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        <recommendedName>
            <fullName evidence="12">Tetraspanin</fullName>
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        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
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                <person name="Penman D.J."/>
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                <person name="Santos M.E."/>
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                <person name="Swofford R."/>
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                <person name="Young S."/>
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                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
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                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="9">Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with ADAM10.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Tetraspanin_EC2_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TETRASPANIN-10"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="274" mass="30038" checksum="3C895E7071959F4E" modified="2019-02-13" version="1">GCGAAKPRYKNTKQSPLRLFFHGLFPKILSYHMQSVVHSSGLLLLALGVWGLISKESFAQEKISSIGTDPMLVVLSVGFLLTVLCLSGCVGALRENRCLLKLFSATVLVLITAQVIIAIVAHTLQDQIESNLRSGMLVAIARYQDDLDLRFITDEIQSNLQCCGADNYRDWEINIYYNCSAPGVLACGVPATCCVDPLENGTVWNSQCGVGAQLLDEFTAQSVIFLGGCLGEISRWIKQHEGLIGIIVTVVFGVQILILFITIRLLERINRHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C896</accession>
    <name>A0A3P9C896_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="35">Dynamin-2</fullName>
            <ecNumber evidence="8">3.6.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Interferon-induced GTP-binding protein Mx</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Interferon-inducible Mx protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="41 42">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="41 42" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="41" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="41" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Phagocytic cup</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="34">Cell projection</location>
            <location evidence="34">Uropodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="32">Cytoplasmic vesicle</location>
            <location evidence="32">Phagosome membrane</location>
            <topology evidence="32">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <location evidence="7">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="31">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="30">Synapse</location>
            <location evidence="30">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="36">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="8"/>
    <dbReference type="RefSeq" id="XP_004559598.1">
        <property type="nucleotide sequence ID" value="XM_004559541.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C896"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018289"/>
    <dbReference type="Ensembl" id="ENSMZET00005018881.1">
        <property type="protein sequence ID" value="ENSMZEP00005018289.1"/>
        <property type="gene ID" value="ENSMZEG00005013718.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473937"/>
    <dbReference type="KEGG" id="mze:101473937"/>
    <dbReference type="CTD" id="559334"/>
    <dbReference type="GeneTree" id="ENSGT00940000155764"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001891">
        <property type="term" value="C:phagocytic cup"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001931">
        <property type="term" value="C:uropod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043009">
        <property type="term" value="P:chordate embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060026">
        <property type="term" value="P:convergent extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061053">
        <property type="term" value="P:somite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000019">
        <property type="entry name" value="Dynamin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000014">
        <property type="entry name" value="Dynamin 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000010">
        <property type="entry name" value="dynamin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000045">
        <property type="entry name" value="dynamin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF23">
        <property type="entry name" value="DYNAMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0007">Acetylation</keyword>
    <keyword evidence="19" id="KW-0965">Cell junction</keyword>
    <keyword evidence="27" id="KW-0966">Cell projection</keyword>
    <keyword evidence="25" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="28" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="26" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="16" id="KW-0967">Endosome</keyword>
    <keyword evidence="22 36" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="23" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="24" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15 36" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0770">Synapse</keyword>
    <keyword evidence="13" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="40">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="38">
        <location>
            <begin position="519"/>
            <end position="624"/>
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        <location>
            <begin position="652"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="37">
        <location>
            <begin position="745"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="37">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="37">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="37">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="37">
        <location>
            <begin position="830"/>
            <end position="854"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
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    <evidence type="ECO:0000256" key="19">
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="24">
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            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003932"/>
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    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="38">
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            <dbReference type="PROSITE" id="PS50003"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="871" mass="97884" checksum="1B392E057D36B98D" modified="2019-02-13" version="1">MGNRGMEDLIPLINKLQDAFSSIGQSCNLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLINNKAEYAEFLHCKGKKFVDFDEVRAEIEAETDRITGSNKGISPIPINLRVYSPHVLNLTLIDLPGMTKVAVGDQPQDIEHQIRDMLLQFITKESCLILAVTPANTDLANSDALKIAKEVDPQGLRTIGVITKLDLMDEGTDAKDIFENKLLPLRRGYIGVVNRSQKDIDGRKDIRAALAAERKFFLSHPAYRHMAERMGTPHLQKALNQQLTNHIRDTLPGLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKCIEGSGDQVDTNELSGGAKINRLFHERFPFELVKIVFDEKELRREISHAIKNVHGVRTGLFTPDLAFEAIVKKQIVKLKTPCLKCIDLVIQELINTVRQCTNKLNSYPRLREETERIVTTHVREREGKAKDQVLLLIDIELSYINTNHEDFIGFANAQQRNTAANKKRAIPNQGEILVIRKGWLTINISIMKGGSKEYWFVLTAESLSWYKNEEEKEKKYMLPLDNLKLRDVEKGFMSTKHIFAIFNTEQRNVYKDLRQIELACDTQDDVDSWKASFLRAGVYPEKDQEENEEPCPADTFSMDPQLERQVETIRNLVDSYISIINKSIRDLVPKTIMHLMINSAKDFIHSELLAYLYSSGDQNILMEESADQAQRRDEMLRMYHALKEALVIIGDISANTISTPVPPPVNDSWMQEASPTAQRRPTPTSSQPPSRPPAVRGPTPGPPLNPSPAFGAPLNPSPAFGAPPIPSRPGPPINAFNSSQDPFSAPPQIPSRPARVPPNIPSRRPPGAPSHRPTIIRPAEPSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C992</accession>
    <name>A0A3P9C992_9CICH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="STRING" id="106582.ENSMZEP00005018850"/>
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        <property type="gene ID" value="ENSMZEG00005014139.1"/>
    </dbReference>
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        <property type="component" value="LG4"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GoLoco_motif"/>
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    <dbReference type="InterPro" id="IPR042168">
        <property type="entry name" value="Pcp2"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR47503">
        <property type="entry name" value="PURKINJE CELL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47503:SF1">
        <property type="entry name" value="PURKINJE CELL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="113" mass="12369" checksum="D10B5E4A3F3B7344" modified="2019-02-13" version="1">SPGSPFLNSHHGRMDEQRCVLNATPQSTPKSENRKFSLYSDNFFSLLANSQGRRLDDQRVSLPSLPGIQNGGTTLTPTAAETDASYLCYLVSKVQVGPICNIAKSYSQLLFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CE98</accession>
    <name>A0A3P9CE98_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transmembrane protein 107</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004541324.1">
        <property type="nucleotide sequence ID" value="XM_004541267.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CE98"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020570"/>
    <dbReference type="Ensembl" id="ENSMZET00005021244.1">
        <property type="protein sequence ID" value="ENSMZEP00005020570.1"/>
        <property type="gene ID" value="ENSMZEG00005015423.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477887"/>
    <dbReference type="KEGG" id="mze:101477887"/>
    <dbReference type="CTD" id="559365"/>
    <dbReference type="GeneTree" id="ENSGT00390000014827"/>
    <dbReference type="OrthoDB" id="2114471at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029248">
        <property type="entry name" value="TMEM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34341">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34341:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14995">
        <property type="entry name" value="TMEM107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="140" mass="15630" checksum="0D0F1BE866152223" modified="2019-02-13" version="1">MSSVSSLVPARFLTIIAHLVIVITIFWSRENNVKACLPLDFTQEQYDTEDRQLVVALSVTLGLFAIELAGFFSGVSMFNCSQSLLSTGVHASASVALLFFLFEQWECHIYWWILAICSVLPALVEILLFIAVFGLKKKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEB4</accession>
    <name>A0A3P9CEB4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">TIMELESS-interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEB4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020374"/>
    <dbReference type="Ensembl" id="ENSMZET00005021026.1">
        <property type="protein sequence ID" value="ENSMZEP00005020374.1"/>
        <property type="gene ID" value="ENSMZEG00005015276.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005764"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:DNA replication checkpoint signaling"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="9">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="226" mass="25580" checksum="0574BD9280BC5D3A" modified="2019-02-13" version="1">MVDPQENSPQDIPDYDGIEDEAFPHSHHHTPQAGEARRKETLLQMVDAAVLISDRGLPALGTLFDNIQFKGKGHEAADLRLLMQKMENWAHRLYPKLQFEDFIDKTCLKRIRLDMPLTHEDFTSTDVSSPDIRILSADCRSPRSPPTPSLTEEQQKRIELNRQRALEKRRARQQQIGKNDETVEDPDLEPSNNTSTQQTSPLPPKTLSPLRLRPASALSNSSATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEX8</accession>
    <name>A0A3P9CEX8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">HIVEP zinc finger 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005020838"/>
    <dbReference type="Ensembl" id="ENSMZET00005021522.1">
        <property type="protein sequence ID" value="ENSMZEP00005020838.1"/>
        <property type="gene ID" value="ENSMZEG00005015625.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005021533.1">
        <property type="protein sequence ID" value="ENSMZEP00005020849.1"/>
        <property type="gene ID" value="ENSMZEG00005015625.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005021539.1">
        <property type="protein sequence ID" value="ENSMZEP00005020856.1"/>
        <property type="gene ID" value="ENSMZEG00005015625.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157218"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000033">
        <property type="entry name" value="Immunodeficiency virus type I enhancer binding protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000594">
        <property type="entry name" value="Transcription factor HIVEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR HIVEP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1508"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1536"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
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            <begin position="1"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="2024" mass="220877" checksum="DD31A5D476D18033" modified="2019-02-13" version="1">MEAEPSHPADGERSGRQAQQHVTSESSLGSCPPQQPQQPSNPRPVHRALGRLQNRQPKRTDLLRLQQQQAVAWQRSDTPGPSGGSFFSTSSSSTLSLPSTSSTQGEHAHGVPTHSSQQGLEGVSSPRKGEKKPQKPGKYVCTYCGRPCAKPSVLQKHIRSHTGERPYPCAPCGFSFKTKSNLYKHRKSHAHRIKAGLASSRDEPSLSGAEGSGAGEDPEEHTEGESTESEDETGQHRKSSKEMLGQHRKGGKERLRSSEESQRPEDSHAVKQRLALRLSERKRGPMASPDDPPSSLSTSSSSIGPGSKGSTESGYFSGSGSTDICQVSPPSSSAKTYAEIILGKYGRLGGQQRSPHQQQPHPSHSSPSGTEEKNISFAVPKTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRKSSMESPKFTAPKDPYAFDPKGEAAGPSGLRHIHNPDADPPGTQDQSAVPLLRSHSMPISTSQGEPFASGTMSPRGYRLCQSFDEQQAVVAEMRIGHAQRMLKRQPAIEVPLGAESMLEEPSPTTSSSSSTRGTELPRQPQQQQQQQKSPAVFECGTCGARFQESEVFEAHRSICPGQEQESRDASKACSVDRPLMMHHKFRALAMAVRKRRKEESLEEDPPSPGSVAVSGSSGGLISVPRRPEQKQALSGVSLQSEPNQQQQQDRKGVSVIQHTSSFEKQESISMESQDPDLRESQQTQPEPKPSPSTSRLIRQPNIQVPEILVTVEPDAEMPPVSPPLTASSSKEAERVEEFHWPQRSQTLAQLPAEKLPPKKKRLRLAEAAQSSGESSFESMSLPRSPSQESNISNFSVSFEDVAQSEQAARAPSSQSSQMLMVPSASHQHHQSHKEMRRSASEQAPASPQQTEQIPEIRSKSFDYGSLSPQQSASSWKERRKCLLVKHAPLGEPEQEVAGRTSQLPRAESPQPGPSYSNLSPLYSTGVSSQFSLDATGKALQLLQPQISLSSQEVLPLHPRGHQAFPPGSLSQLLPVTTAISEVLSTQIIQRAFLQSHTESPPVQIHPVQIHMAERLGIPLHQLPPPFPRHFSSRNTSSQAMYLPVPPRFTTHISSPQTTESRPPISSVSSSLTQESLVTISYHHPRPVIATCLAQLAPVVSLVVPVRLQTHIPTYASAMYTTLSQILVSTRSQEPVSCTAMVIMGQVERETLQRSYLKVPSPDVKSLLPLSLSSELASGSGDGYGPLGAGGSKRMLSPAASLELSTEAQRHQKRVKEEEEEEEEEEGHHKEEEEEGRVEPKVVQEEERKATGKKLEKEKKKSDTLEVTSVDVHGQPEDQPRKNDREEKVEEKETTEKITQKKEAVSAVEVGASASSFPSLHTSTSVNWCYQKYVKPNPSAQRDPRTSVYSTWSVSAHNPNLPGISTKVALSLLCSKQKHTSEIYTMATAPTPAEVKVAPENSRTPHVSEVHATPPSTLTEVKEQQQPEKKEENKEMREVERPSTSKQSEPSRVCIFEGGYKSNEEYVYVRGRGRGKYICGECGIRCKKPSMLKKHIKTHTDVRPYICKHCNFAFKTKGNLTKHMKSKAHGKKCQAMGVSESSLDEPESEETAGSEERVCGSEEQEEHQFSDVEESDDDEDNDDDDDEEEEEESTSHENPPSSVSSDTHPSTGGRSSSSRHSKQGTPDPEPPGPIPCTSQEPSPRGVWPGRRAASPGSRRAVFSRRGWKASPRAFSPSSESCSPSRSLSPRLEYSSPIQSLSPRTELPSPSRHVSPSPERGPSPIRPLSPLLPLSPSCYRSSQVPTPPSPLGMQHRTPGYLPWENPGTSGSHMRVEKSRTAGEGPTWSDTSLFPPAFRISTCEGYPGLQTTDNIFSHLPMHSQQAKVPYSMIPIGGIQIVQARPRSHATTPTSPTSPPMEGPSLARFETYWGGTPRTQGLRTPGDHWSEHQTAGTSQSGQQGLSTALTFSKTELEATDSKQYGSSHSSVHTHGSSTETTEHCASDDRSRAPPSLTPPVASSVIGQQPEREERTSGSDMVAGGAKGDSATRDQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CG77</accession>
    <name>A0A3P9CG77_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of G protein signaling 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004567360.2"/>
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    <dbReference type="Ensembl" id="ENSMZET00005021849.1">
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        <property type="gene ID" value="ENSMZEG00005015881.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101487319"/>
    <dbReference type="CTD" id="5999"/>
    <dbReference type="GeneTree" id="ENSGT00940000159036"/>
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        <property type="component" value="LG17"/>
    </dbReference>
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        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
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    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF184">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="64"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="208" mass="23458" checksum="67BC9DD705D6FA9A" modified="2019-02-13" version="1">MCKGLATLPATCLKSAKDIKHKISFLLQKPEPQAADQKQMKEKSTTAAAKRVPNTAEVEKWKESFSHVLNSEVGRTVFTSFLKSEFSEENMDFWMACEDYTKTAPTKLATRAKQIYQKYIGADALNEVNLDAATREKTRQNVENACPSCFDDAQKMIYTLMEKDSYRRFLKSKLIQDLCQQQSNAAQEKKEKRSCDMADSSQVLAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGS7</accession>
    <name>A0A3P9CGS7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm autoantigenic protein 17</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
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                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CI11"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021486"/>
    <dbReference type="Ensembl" id="ENSMZET00005022195.1">
        <property type="protein sequence ID" value="ENSMZEP00005021486.1"/>
        <property type="gene ID" value="ENSMZEG00005016138.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155282"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000008">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001328">
        <property type="entry name" value="Dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF1">
        <property type="entry name" value="DYNEINS HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="303" mass="34255" checksum="353891DDF317396E" modified="2019-02-13" version="1">MRAVKSVLTAAGNLKLTFPEENEDTLLLRSIIDVNLPKFLDHDLQLFEGITSDLFPGVKLPKRDYNVLLEAIEDNCRQMNLQVTEFFAEKILQIFEMMIVRHGFMLVGEPFGGKTSAYRVLAAALHDGLMDENQVQITVINPKSITMGQLYGQFDPVSHEWSDGILAVSYRSFAASQSPDRKWLIFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSPQMSLIFEPMDLEVASPATVSRCGMIYMEPHMLGWRPLMLSWLSTLPPTVSATHKDLITALFDRLLPACLQLIRKATKVLRNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CK28</accession>
    <name>A0A3P9CK28_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gastrula zinc finger protein XlCGF42.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004561090.1">
        <property type="nucleotide sequence ID" value="XM_004561033.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CK28"/>
    <dbReference type="Ensembl" id="ENSMZET00005023405.1">
        <property type="protein sequence ID" value="ENSMZEP00005022655.1"/>
        <property type="gene ID" value="ENSMZEG00005016963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473267"/>
    <dbReference type="KEGG" id="mze:101473267"/>
    <dbReference type="GeneTree" id="ENSGT00940000154715"/>
    <dbReference type="OrthoDB" id="8392834at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001715">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF151">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="290" mass="32691" checksum="DA56095440EDDE78" modified="2019-02-13" version="1">MEARREGLPPDVQKVIVGDEEEQEGVFIKEEQEEVDIIKFTFSPVAVKSEEDEEKPESSKLHHTLTEKRRDSVGGEDAGRPAPDPGLDPEDKDMETEVHEGDLEESSEPSSSEESKVLAGDMKCVSGEEALICTECGKSFKRMAHLLRHKRSHTGEKPFGCPKCDKRFVQSGSLKKHLWTHTGQKPFSCSECGRCFMEKAALTNHMTLHTGEKPFSCSECSKPFSCRSALNAHMKIHSGEKNFSCSTCLKTFTWNYQLNRHKCISPKPARNRVLMPRPHNDKVVVFVHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLE7</accession>
    <name>A0A3P9CLE7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B</fullName>
            <ecNumber evidence="3">2.1.1.361</ecNumber>
            <ecNumber evidence="4">2.1.1.362</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">[histone H4]-lysine20 N-methyltransferase KMT5B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <reaction evidence="19">
            <text>L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60344"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.361"/>
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            <dbReference type="Rhea" id="RHEA:60345"/>
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    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61992"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
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            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
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            <dbReference type="Rhea" id="RHEA:61993"/>
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    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
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            <dbReference type="Rhea" id="RHEA:60349"/>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="nucleotide sequence ID" value="XM_012923963.2"/>
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        <property type="protein sequence ID" value="ENSMZEP00005022634.1"/>
        <property type="gene ID" value="ENSMZEG00005016943.1"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <sequence length="867" mass="97801" checksum="348F43E055CF656F" modified="2019-02-13" version="1">MKWLGESKNMVLNGRRHGNKLTGEQTVSPSQTRSQHPQRASLRHSKSHTRNRRCSRRFNAASLEAERRYVPSSGMTAKELCENDDLTTSLILDPYLGFQTHKMNTRFRPIKGRQEELKEIIERFKKHDNLEKAFKALTSGDWARNIFLHKTKAQEKLFKQHVFVYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIEYLVGCIAELSESEENLLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSKAGLPVEVPVINSKYGLRETDKRLNRLKKLGEGNRTSDSHSVGSHTDVDSQEMPKTHQSARKRTSSSSSSSGLKYKNRTQTRQTLSRALTTSCSKQGRANNNRVPKRLRSQSKPSLSKVQLRSRKRGAEPKALAKQETCQLGLTDSKMSLCKGVTVKKEKDGQELVQQTLGQQGYLTRHTAKENGHLPAVQSSEGSQCSMYRTRRSTRTLVKARETASGVKLEPSAMDGLSPVPGGVVIKTEPADMEEYLHHGVELEHPSLDAGYARRRSSTRQKRPARIRAERTIKCEDTYGESFMQVVGSHAAEFSDCGNMLLSFADQHRDYNCVTHGSKSFHRDKGKGSCRSQDKGKKKRRITRYDAQLILENNTGIPKLTLRRRRDSSSSKTTDPNDPVGSSHLSASTVNSPSSSKISIKFSKDHDKDKGSSYIAKLNNGFAPVVHSNSTKLNIQLKREDDARRLSQTKVDQISFNGDMSQGLETRNGGHLTQKVLADPSSDDEDKEVEDDDDYFDNEFEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLP9</accession>
    <name>A0A3P9CLP9_9CICH</name>
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            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="344" mass="38223" checksum="2E6A23A964CE5C70" modified="2019-02-13" version="1">SSKYGLHRSCYASFVRCTKAPVLKGTFAYPSDVLERHEEMLKHVSKEQTALLQAMTELKGMLISSPNTAPTQPAPSLEAAAACPLPPSPPPRQREYSLPAPEKFDGELGRSRGFLTQCSLVFRQQPCAFASDSTKIAYLVQLMTGRALQWAQAVLNTQPSVSYDVFLSKFRCVFDKGASSDAAGHRMFSLKQGRRSVADFSVEFWILAEESGWEEKALRGAFLNSLNENIKRELATKELPKALSALINMCINLDDHMREFGRRAGDGRRPAGGTGTSRDRPTLMWRSEEEEQHGDEEQPMQLGGAKLSSSRLGRKQRTGECFLCGKRGHFVDSCPDRVKESARQ</sequence>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
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                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
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                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="241" mass="25590" checksum="588560F919AC5CA2" modified="2019-02-13" version="1">MSAAASQKVVLKSTTKVSLNERFTNMLKNKQPTAVSIRATMQQQHLASARNRRLAQQMENRPSVQAALNHKQSLKQRLGKSNIQARLGRPVGALMRGGPPGGRGGMRGMNRGGLRGRGRGGIMRGALSLRGKRGSTGGPMRGRGSAGRMAMRRGGRQRGAGVGRGGALSRGAARGMPRGRGGLRGRGGFAGRRGRGRGVGRPAVTREQLDNQLDAYMSKTKGHLDAELDAYMAQADPDSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CM96</accession>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
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                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CM96"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023450"/>
    <dbReference type="Ensembl" id="ENSMZET00005024222.1">
        <property type="protein sequence ID" value="ENSMZEP00005023450.1"/>
        <property type="gene ID" value="ENSMZEG00005016826.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286901"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015125">
        <property type="term" value="F:bile acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF89">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="24"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="437"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="769" mass="84949" checksum="558A11106DF2770B" modified="2019-02-13" version="1">VVETQKRGQNHFHDYTMTLFGYLFIVALSFAYFSKALTGTYMKSSITQIERRFDLSSTHIGLIDGSFEMGNLLFLAVVSHFGAKLHRPRLIAAGCFLMAVGAFLTGLTHFFMGRYKYDTVIQVFQNDNLSIAACVDPLKTLDHVPEIQIEPSLEDNKDSGSSMWIYVFLGNALRGIGETPVTPLGISYIDDFAKAENSPFYIACLQTITLLGPMFGFLLGSYCARLYVDIGYVDMESVTITPKDSRWVGAWWMGFLVSSGLLLISSIPFWFLPRSMPKQESEENHETPVCEILNKTEDAQSNNQNFKLTEIAKGFLPSLRHLLGTPAYFLLLCGNILKFNAFIGLLTFKAKYMEQQFGQSASRANFLIGVLNLPAVAIGIFLGGLLMKRYKLSVVSGAKLSFATSFMSYLLMLLQFGTKCDNIPIAGLTVSYNGSVEMLFSECNRDCLCSAEEWDPVCSDSGITYISPCMAGCLSSSGHGKNTVFHNCTCVSTSFPAGSSTSVRLGQCPHAKDCSRSFTSYMAISVLSSFINALGATPGYMVIIRCITPELKSLALGIQTLVTRTLGGIPAPVYFGALIDSTCLKWSMKSCGGRGACRIYNSDMYRIIFLGLITCISGSSYFFLIAVIILLRRQFRKPEKDTDKQEQKASKDFELKTPLNLTEEIRASPETPNLPSATKIWVKIATDLEEGGEVHTVELPPHNDGVISTNNAQEANYMTDTCAEVIPLSSDGTNTEIVRKESIGHKVIEKQDDHIDDKSKLEKERQQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNM0</accession>
    <name>A0A3P9CNM0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Southpaw</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004544784.1">
        <property type="nucleotide sequence ID" value="XM_004544727.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CNM0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023391"/>
    <dbReference type="Ensembl" id="ENSMZET00005024157.1">
        <property type="protein sequence ID" value="ENSMZEP00005023391.1"/>
        <property type="gene ID" value="ENSMZEG00005017508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479208"/>
    <dbReference type="KEGG" id="mze:101479208"/>
    <dbReference type="CTD" id="338101"/>
    <dbReference type="GeneTree" id="ENSGT00940000163919"/>
    <dbReference type="OrthoDB" id="5949851at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007369">
        <property type="term" value="P:gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13759">
        <property type="entry name" value="TGF_beta_NODAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000026">
        <property type="entry name" value="Nodal homolog 3-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF159">
        <property type="entry name" value="NODAL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017961662" evidence="11">
        <location>
            <begin position="17"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="12">
        <location>
            <begin position="277"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="412" mass="46633" checksum="940811FEFF5BF55D" modified="2019-02-13" version="1">MEVLIVFICAFGVVSSARGHRYHTGLESSLAFRNLSTDHRRGYPLYMIQLYRSFRSADSSSSVAVSDVTAQSDSLSVHSFDSVKSLMARGCHQEGEKWTVTFDMSSISTSELVQLAELQIRLPAFSASERATVDLYHSRKQSCDLDDTSCQEERLFLGSFGTSPSSTKSSWKVFNVTSLLKYWLYQGDEVQSREASGEPETQYGSGAGDGVEKTRKSLFTTLGLRQRKIRHPTTNQVMMVIFSKHKEGHAAYSLIHTVENSKYVSMDKEGSDIQSRRHKRNRMERMRVAGVLAPTVAPAPSAAAEQVQRPLCRKVDMWVDFDHIGWDEWIVHPKRYNAYRCEGECPTPLDESFSPTNHAYMQSLLKHHHPERVTCPSCVPTRLSPLSMLYFESDDLTLRHHEDMIVEDCGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CP50</accession>
    <name>A0A3P9CP50_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras homolog family member Q</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554629.1">
        <property type="nucleotide sequence ID" value="XM_004554572.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CP50"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024133"/>
    <dbReference type="Ensembl" id="ENSMZET00005024924.1">
        <property type="protein sequence ID" value="ENSMZEP00005024133.1"/>
        <property type="gene ID" value="ENSMZEG00005018052.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474497"/>
    <dbReference type="KEGG" id="mze:101474497"/>
    <dbReference type="CTD" id="23433"/>
    <dbReference type="GeneTree" id="ENSGT00940000155970"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04135">
        <property type="entry name" value="Tc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000438">
        <property type="entry name" value="Rho-related GTP-binding protein RhoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="207" mass="22885" checksum="C45D2AE64CD7C290" modified="2019-02-13" version="1">MANGTGTIMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVNVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVREEWVPELQEYAPSVPYLLIGTQIDLRDDPKTIAKLNDMKEKPIATEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKRKKGSLKRRLGPRCINCCLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPC6</accession>
    <name>A0A3P9CPC6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 43 member A</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPC6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023884"/>
    <dbReference type="Ensembl" id="ENSMZET00005024668.1">
        <property type="protein sequence ID" value="ENSMZEP00005023884.1"/>
        <property type="gene ID" value="ENSMZEG00005017873.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161593"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="CDD" id="cd01214">
        <property type="entry name" value="PTB_FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033930">
        <property type="entry name" value="FAM43A/B_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF36">
        <property type="entry name" value="PROTEIN FAM43A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="72"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="361" mass="40519" checksum="A7784C15A50C5A6D" modified="2019-02-13" version="1">MLLLTGNSSKMLPWKKNKFDLIEEDKQSKQKGYAVSLNYSALTSFAKSCPESALNRVGSMFKSKRKKLKITSEDPTYTVLYLGNATTIQSKGDGCTDVAVSKIWGKSEMGKNGTKMRLTISSQGIRMVHVDDKARRPGHLYLLHRITYCVADPRLPKIFAWIYRHEMKHKAVMLRCHAVLVSKPEKAKAMALLLYQTSATALAEFKRLKRRDDARHQQQQLIGEQTIPLVPLRKLLNGQCYYKPPVERSRSAPKLGSITEDLVGEEEEEKAMHFECEDILDTDTDCVANGKQELTQIINDLGEMSIGNDVQTLKADLRVTRLLSGESTGSESSIESNQEPPPLINGFDEVSIQDDKERVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CS95</accession>
    <name>A0A3P9CS95_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CS95"/>
    <dbReference type="Ensembl" id="ENSMZET00005025755.1">
        <property type="protein sequence ID" value="ENSMZEP00005024944.1"/>
        <property type="gene ID" value="ENSMZEG00005018619.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162108"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000002">
        <property type="entry name" value="Scavenger receptor cysteine-rich type 1 protein M130"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000009">
        <property type="entry name" value="WC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF22">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="231"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="353"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="455"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="558"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="664"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="769"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="891"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="161"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="379"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="392"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="479"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="492"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="587"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="600"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="690"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="703"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="795"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="808"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="917"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="930"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1034"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1124"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1137"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1168"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1234" mass="133187" checksum="6831CB293194D54E" modified="2019-02-13" version="1">REGGRHATKDRGSDFNPGRPLSASTRCSGRVEIYHNNSWGTVCHYGWDINDAEVVCSQLDCGPALNATREDVFGEQTGQIWLDDVSCSGTESSLTECQHGGFGKHYCEDFWYAGVICSGVRIRLAGSGSTPCAGRVEYYYKKRWGTVCDNDWDINDAEVVCRQLDCGPALKATQSAQFGEGKGDIWLDNVACSGSESSLTECQHRGFGTHNCGHHRDAGVICSVYFFCLGIRLAGSQSPSSGRVEIYHNNSWGTVCDDGWDINDAEVVCRQLVYGTALAAPKEAHFGEGSGPVWFDGVACFGNERSITQCQLGEFGSSCRHHKDAGVICSGTALISSSRVVLSAYSMCSGVAIRLAGSLSTRCSGRVEIAYKKTWGTVCDDNWDINDAEVVCRELNCGTALNATRSAHFGEGTGEIWLDDVSCSGSERSLTECQHRGFGIHSCTHSEDAGVSCSVRLSGSTLCSGRVEIFYNNTWGTVCDDNWDINDAEVVCRELGCGTAQSAAVSARFGEESGSIWLDDVDCSGSERSLTECQHRGFGTHDCTHSQDAGVVCSDAQIRLIDPDNSGATLCSGRVEIYHNNRWGTVCDHGWDLNDAEVVCRQLDCGPALNATRSAHFGEGTGQIWLAGVSCSGSESSLTDCQHRGFGIPYCGHYEDAGVICSEIRLTGPQSTRCSGRVEIYHNNRWGTVCDDGWNLNDAEVVCRQLGCGSALEATQSAHFGEGTGQIWLDDVTCSGSESSLTQCQHRGFGTHDCTHQKDAGVICSGVPIRLAGSGSTQCSGRVEIYHQKTWRTVCDDGWDLNDAEVVCRQLDCGSALKATQSAHFGEGTGNIWLNEVSCSGSESSLADCQHRGFGTHSCAHHRDAGVICSGETLFDSCTCNTEKYVSCAIFCIINCVFDCCSGRVEIYHNKIWGTVCDHGWSTEDAEVVCRHLGCGPALNATQSAHFGEGTGQIWLDEVSCSGSESSLTECQHRGFGTHSCGHGEDAGVICSGETLFKSRTSGRCSGRVEIYNKKRWGTVCDDGWDLNDAEVVCRQLDCGTALAPPKEAHFGEGSGPIWLDGVACSGSERSIIQCQHRGSEKNGCTHHKDAGVICSGARIRLTGSTHCSGRVEIFYNNTWGTVCDDGWDINDAEVVCRELNCGTALKATKSTHFGEGRGSIWLDDVSCSGSERSLTECQHRGFGKHDCTHSKDAGVVCSASTRRIYSEADFRLIQSEKTINHQLCYIQDPQSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CTL2</accession>
    <name>A0A3P9CTL2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cell adhesion molecule 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004552195.2">
        <property type="nucleotide sequence ID" value="XM_004552138.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CTL2"/>
    <dbReference type="Ensembl" id="ENSMZET00005026227.1">
        <property type="protein sequence ID" value="ENSMZEP00005025404.1"/>
        <property type="gene ID" value="ENSMZEG00005018958.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101466724"/>
    <dbReference type="GeneTree" id="ENSGT00940000159005"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047012">
        <property type="entry name" value="ICAM_VCAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003987">
        <property type="entry name" value="ICAM_VCAM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771:SF9">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01472">
        <property type="entry name" value="ICAMVCAM1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017963346" evidence="12">
        <location>
            <begin position="22"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="110"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="352" mass="38685" checksum="B8037AA635F3914A" modified="2019-02-13" version="1">MVWSFFFFGLLIACTGNPASASCPLQMSPSRVVVKFGDALSAKCTSLSNQTEGMGWESPYGGLDNTKGVTFLDFKIDSVPVWELEPICFVNFHDGDQCTEVLPVTVYKMPDSVSLRQNSTTVKEGEKFAIQCDIVNVAPARNLSVLWHKGNKILNSETFIESSPSPVSKSSVLTLTAHRDDDGAEIWCEAKLNLWPGEQGPAMMRSMSHRVTVFYPPTYTKAGNETLEMTVGENMTLNCNAKGNPPPSYHWEFPKFTKEWHDKEEVIEPILTLPFELPGVYTCTAYSNQGNVIKYFNISEAPRSRTTFGVMVGVGVAVGVLLLIAGAYFVTPNGTFSFNKGGYQPGTPSRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CTW9</accession>
    <name>A0A3P9CTW9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone H3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024656258.1">
        <property type="nucleotide sequence ID" value="XM_024800490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CTW9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025472"/>
    <dbReference type="Ensembl" id="ENSMZET00005026298.1">
        <property type="protein sequence ID" value="ENSMZEP00005025472.1"/>
        <property type="gene ID" value="ENSMZEG00005019010.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:112431766"/>
    <dbReference type="GeneTree" id="ENSGT01150000286903"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000047">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="4">
        <location>
            <begin position="44"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="129" mass="14863" checksum="31ECE7664DCF14A6" modified="2019-02-13" version="1">MARTKQTARKSTGGKAPRKQLATKAVRKSAPATGGVKKPHRYRPGTVALREIRHYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQRHPAGSLHPRRESLNCTLSYQQRLFSEPPHSHQELAPLFLFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVH9</accession>
    <name>A0A3P9CVH9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Myb-like, SWIRM and MPN domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family. MYSM1 subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVH9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026390"/>
    <dbReference type="Ensembl" id="ENSMZET00005027243.1">
        <property type="protein sequence ID" value="ENSMZEP00005026390.1"/>
        <property type="gene ID" value="ENSMZEG00005019695.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157721"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904888">
        <property type="term" value="P:cranial skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08067">
        <property type="entry name" value="MPN_2A_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000193">
        <property type="entry name" value="histone H2A deubiquitinase MYSM1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SWIRM" evidence="18">
        <location>
            <begin position="225"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="17">
        <location>
            <begin position="428"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="725" mass="81964" checksum="6E904A0672A3F91C" modified="2019-02-13" version="1">MESRTVLQVKSYARQYFKHKAKSDPGPAAPSVAPIIHLQPPQPTSSQVSTLANAVRIEKLSDDEDEDVDITDDLSDDEEGNKPQAVLSSDFCGPEEKTDSGSQSPTEEHVSLSGVESIHETKEKPSHTSLSPQSLQPSSFPGCSEDPGVTERDEKVNKTASVFPQSCQTPPHADSKQMFSTGIAQLEEAYSDGMDSSDKIEKNLNDRPYNDQEEEENEDDEEEELKAPEQEIEMDTETITEDEKQAIPEFFEGRPSKTPERYLKIRNYILDQWLKSKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFNCEQAVYNRPKVMDRSKHKEGKDVLEAYQLAQRLQSMRTRKRRVRDIWGNWCDAKDLEGQTYEHLSAEELALRREEMKKQPKPYKMSRYRGSFDPFQLIPCRYFEEDIKEPFQVIVCAETLLIMDMHAHVSRGEVIGLLGGTFNEEAKVLKICAAEPCNSVSTGLQCEMDPVSQTQACDVLSSLGFSVVGWYHSHPSFHPNPSLRDINTQHQFQSYFSRGGAPFIGMIVSPYDPANASPHSQTTCLLVKENQEPSGPQKLPYRFDFLSSQDIPDWEQTMRRAQWIIHKYSQAPGSVQMDRLFRRDSHLTCLEKMLASLARYLEPLPDEVGDSFLTQIQALFKSDFISKQQLPDSEEGEPLNISSKLVDSGELTFDQPISPEEEKDQEESETTGSTVLHLGSVLSTEHDYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVN3</accession>
    <name>A0A3P9CVN3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">BTB/POZ domain-containing protein TNFAIP1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BACURD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538017.1">
        <property type="nucleotide sequence ID" value="XM_004537960.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVN3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026047"/>
    <dbReference type="Ensembl" id="ENSMZET00005026886.1">
        <property type="protein sequence ID" value="ENSMZEP00005026047.1"/>
        <property type="gene ID" value="ENSMZEG00005019421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476558"/>
    <dbReference type="KEGG" id="mze:101476558"/>
    <dbReference type="CTD" id="7126"/>
    <dbReference type="GeneTree" id="ENSGT00950000183143"/>
    <dbReference type="OrthoDB" id="2333377at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000046">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="326" mass="36928" checksum="B76B9A876E4078B9" modified="2019-02-13" version="1">MSGDSCLPQDLSKSETTSPDLPLACPKTKTCSHHGAVGLGNKYVRLNVGGMLFYTTLQVLTKQNSMLKAMFSGKKEVFTDKDGWILIDRSGKHFGSILCYLRDGRVALPKGRQAVQELLVEAKHFLVQGLVELCQNSLQGNKEQPMCVIPVVTSIKEEEKLIQSSTKPVVKLVYNRSNNKYSYTSNSDDHLLKNIELFDRLSLSFNGRILFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNTLLYETMPLPDNSLLEATRRRYNNCGSHSEEEEGPGGPELRERVRRIHVKRYSTYDDRQLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYW9</accession>
    <name>A0A3P9CYW9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CYW9"/>
    <dbReference type="Ensembl" id="ENSMZET00005027887.1">
        <property type="protein sequence ID" value="ENSMZEP00005027021.1"/>
        <property type="gene ID" value="ENSMZEG00005020156.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153582"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000965">
        <property type="entry name" value="Neurotrophin receptor-interacting factor homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000188">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="541" mass="61497" checksum="EA9F16309919DCAB" modified="2019-02-13" version="1">MPLATSLAIFQSCNITGVPKSTRCAILRDMAKVRKAERRPPLNKTHKTEEASRMRGETSSRKLKEVQTVNGGRFSLFEDCISLTASVSPSLQDQHGERSQCSQEADKLHRNKAEETYSCDECGKEFIGQSNLKCHQLIHTEERQFSCDLCGKSFTKPEHLKTHQLIHCKVKASRPCHRCGGGKAFRCDLCGKTFNQQRCLKLHQRRHTGDKMSYCKECGKGFPTPSELKIHELCHSGVKKHLCDQCGSSFTTACDLRKHKRVHTGEKPYKCRHCDRSFSQSSNRNLHERTHVKGSYSCDQCDKNGSSSRPCRHCGGGKALRCDLCGKTFNNEKNLKLHQRRHTGDKMNYCKECGRGFPTPSALKEHEIYHSGVKKHVCDQCGSSFTTADHLKVHKRVHTGEKPYNYCKECGKGFPIPSKLKEHELCHSGVKKHVCDQCESSFTIARDLKIHKRVHTGEKPYKCRHCDKSFSRSGHRNIHENTHIEGNFSCDQCDKSFKNLSSYSEHKRSHAVNKLFHCYQCAKTFTSLSALCKHQRDHAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZQ0</accession>
    <name>A0A3P9CZQ0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Si:dkey-46i9.6</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZQ0"/>
    <dbReference type="Ensembl" id="ENSMZET00005028173.1">
        <property type="protein sequence ID" value="ENSMZEP00005027301.1"/>
        <property type="gene ID" value="ENSMZEG00005020365.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240385"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF49">
        <property type="entry name" value="BLOODTHIRSTY-RELATED GENE FAMILY, MEMBER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="335"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="531" mass="60920" checksum="6D73762ED5871347" modified="2019-02-13" version="1">MQRMATTGNLSEEQVHCSICLDVFTNPVSIPCGHNFCQSCILGYWKSSPLYQCPMCKKSFYKRPDISVNTVLREIAEQFKEIRIKSMEGKGSKEEGEGKERKPNAVKSCLVCLTSYCEEHLKCHSARFTKHKLMEPVANMEDRMCPKHERLLELFCKKDQMCVCVLCTETDHRAHYTVPVEREWTEKKVRQMRIDVQQMIQDRVKKVEEIKHSVELNKASAQREIEESMQVFSELVRSIQKTQAELVLVIEEKQRQTERWAQGLITELEQEITELKRRNTDCCPPLGCIFLQSFPALSTPPSVKDWSETSVPTDTCVGMIRKLVSKLEATLTEMIDKLSDSGRTSINIQKYLLDVTLDPDTANPWLQLSQDRHQVRHLGAWQDLPDHPDRFDTVVIVLAHEGFTSGRHYWEVQVGEKDDWYLGVARSSVNRKGRISVSTTQGYWALAMKKGQGYRASTSPPSLLSLDPKPKRVGVYVDYEEGQVSFYDVRARTHIYTFEDTFTEKILPFFYLPASSHGSKTSALGLTGNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZY9</accession>
    <name>A0A3P9CZY9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZY9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027893"/>
    <dbReference type="Ensembl" id="ENSMZET00005028780.1">
        <property type="protein sequence ID" value="ENSMZEP00005027893.1"/>
        <property type="gene ID" value="ENSMZEG00005020801.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271858"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF170">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="220"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="315" mass="36250" checksum="0E8F704B7CC93FAE" modified="2019-02-13" version="1">MKPGNTNESYSTFQIKSELIKPSLNLVLMVLLGKTGSGKSATANTILGKKVFLSKVSQISVTRECQKAAGEIDGCPVVVVDTPGLFDTTLSSYEVRQELLNCISMLSPGPHVFLLVLQIGRFTEEEKETVKKIKEIFGKKSGNFIIVTFTKEDELEDTIESYIEEDCSDFVKTLIDDCGGRYHVFNNKDPKNRRQVSDLLMKIEAMLKDNYGGYYTTEMFQEAEAAIQKEMERLLKQKDEDMMREREVLKRKHEGEMQKVKRQMEEQISKFESEKEQKLPPKQKKNRGISHYNMKTCSNNIFFTFEQHKNYIVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D0H4</accession>
    <name>A0A3P9D0H4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3 13">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine.</text>
    </comment>
    <comment type="function">
        <text evidence="13">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3 13"/>
    <dbReference type="RefSeq" id="XP_004570718.1">
        <property type="nucleotide sequence ID" value="XM_004570661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D0H4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027859"/>
    <dbReference type="Ensembl" id="ENSMZET00005028747.1">
        <property type="protein sequence ID" value="ENSMZEP00005027859.1"/>
        <property type="gene ID" value="ENSMZEG00005020781.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477825"/>
    <dbReference type="KEGG" id="mze:101477825"/>
    <dbReference type="CTD" id="791647"/>
    <dbReference type="GeneTree" id="ENSGT00950000182991"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047975">
        <property type="term" value="F:guanosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF12">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="15">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="295" mass="32675" checksum="36CF80468BAD5DDE" modified="2019-02-13" version="1">MFPEENSCYSYEECKATADWLLAQTDTRPTVGIVCGSGLGGLADLLKDQVAFNYKDIPNFPQSTVHGHAGKLVFGHLKGRPCVCMQGRFHLYEGYSIQKITLPMRIFKMLGVETVMLTNAAGGLNHDFKMGDIMIIKDHLNLPGFAGINPLNGPNDERFGVRFQCMSDAYDRELQQLAMDVGQDLGYGDFLKEGVYCVLGGPTFETIAEGRMLHRLGADAVGMSTAHEVIVARHCGMRVFALSLITNQVVMNYDSEERANHEEVLQVGRQRAAQLERLVSTMVTKIVHNNDGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D0P1</accession>
    <name>A0A3P9D0P1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Peripheral plasma membrane protein CASK</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Calcium/calmodulin-dependent serine protein kinase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 33">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D0P1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027752"/>
    <dbReference type="Ensembl" id="ENSMZET00005028632.1">
        <property type="protein sequence ID" value="ENSMZEP00005027752.1"/>
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            <begin position="769"/>
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            <dbReference type="ARBA" id="ARBA00071925"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="27">
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    </evidence>
    <evidence type="ECO:0000259" key="29">
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    </evidence>
    <evidence type="ECO:0000259" key="30">
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="901" mass="101766" checksum="7540E855CD12A547" modified="2019-02-13" version="1">MADDDILFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAQFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNVIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEAICKGKYKMNPRQWNHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELQDFSDDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEISSQDGACGALKLLEDVLEEISCYPEKHEAKELRRIVTQPHFMALLQAHDVVAHEVYSDEALRVTPPPTSPFLNGDSPESANGDMDLENVTRVRLVQFQKNTDEPMGITLKMNESNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQGSSCENESPTTSRQSPANGHSSINSSILDLPSTIQPKGRQIVSRPPIKDKMSVKIYVRAQFEYDPSKDELIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENTKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKLPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTRLETIRKIHQQGLIAILDVEPQALKVLRTAEFAPYVVFIAAPTITPGINEVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D2P1</accession>
    <name>A0A3P9D2P1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Family with sequence similarity 174 member B</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM174 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D2P1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028624"/>
    <dbReference type="Ensembl" id="ENSMZET00005029529.1">
        <property type="protein sequence ID" value="ENSMZEP00005028624.1"/>
        <property type="gene ID" value="ENSMZEG00005021342.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111392"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009565">
        <property type="entry name" value="FAM174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607:SF3">
        <property type="entry name" value="MEMBRANE PROTEIN FAM174B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06679">
        <property type="entry name" value="DUF1180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018284710" evidence="9">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="151" mass="16514" checksum="97C95625BC84BED9" modified="2019-02-13" version="1">MVAHNLALTFIAAALWGVSGELLLTPSSATHLNSTSSSSVISQDSLTNNATDAAVGSRISSLMTYLPTLKNIVIFICVLTAALITCLVIKVVRSGRRIRKTRKYDIITTPAERVEMAPLNEENDEEDDSTLFDVKYRLVCFVFISFGSLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D3R1</accession>
    <name>A0A3P9D3R1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 26</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D3R1"/>
    <dbReference type="Ensembl" id="ENSMZET00005029634.1">
        <property type="protein sequence ID" value="ENSMZEP00005028726.1"/>
        <property type="gene ID" value="ENSMZEG00005021425.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014794"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29681" checksum="795F417D757EE1D4" modified="2019-02-13" version="1">MLALQQTGNLSRVCENWVAGLEQTMLIVLVLGRWLMPKGDMSRDQLSQLLMVNVGLGADILDIFDTFKEPEVKTNQAVVIIGLALFSWALMQFPLVLTQTRPPKAGPSQDSKGGPFCCSRAPPSFTSCCSSEVWSLLLTVGLQDGPFLLYRFYLMVQEQVLNQLMIFFTCKNILIVLLELYRIFVVQCEQQVSGLERCTRGTSEAEAKPERNSLNLNRCISHDSAELSHHMPQSPCFVSTNQEVQTRQGLPHQPPILQINPSKCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D446</accession>
    <name>A0A3P9D446_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peroxisome biogenesis factor 2</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="RefSeq" id="XP_004546575.2">
        <property type="nucleotide sequence ID" value="XM_004546518.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D446"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029405"/>
    <dbReference type="Ensembl" id="ENSMZET00005030333.1">
        <property type="protein sequence ID" value="ENSMZEP00005029405.1"/>
        <property type="gene ID" value="ENSMZEG00005021938.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101463806"/>
    <dbReference type="CTD" id="5828"/>
    <dbReference type="GeneTree" id="ENSGT00390000001846"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16526">
        <property type="entry name" value="RING-HC_PEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045859">
        <property type="entry name" value="RING-HC_PEX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029405.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="330" mass="37023" checksum="A5979721905F6AA3" modified="2019-02-13" version="1">MAGLGSENDQKKTARSHGPHFDMNPQTPVLRISQLDALELDSALEQLVWTQFSLCFQNCRPGFLTPLEPELRVLLHLLLWRFTLYSNSATVGQSLLSLRYHSKFSLSPRYRPLSPRQKLGLAVLTAGPLWLQERSHRLLPYLGLSSQGSGSERESGLLHQGLRNALTLVAGIVKFTNLINFLVFLRNGRHPILAERITGAQTVFSKPNVAREVNYKFMNRELLWHGFAEFLIFLFPLINTKKLKATILSAVFGGESASGEGAREGQELWKECGLCGEWPTMPHTVGCQHVFCYYCIKSHSIADPYLTCPKCGAEAGQPKLVKLEVEMTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3P9D537_9CICH</name>
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        <submittedName>
            <fullName evidence="17">Calcitonin gene-related peptide type 1 receptor</fullName>
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        <name type="common">zebra mbuna</name>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
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    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
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        <property type="nucleotide sequence ID" value="XM_004574948.3"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005029322"/>
    <dbReference type="Ensembl" id="ENSMZET00005030243.1">
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        <property type="gene ID" value="ENSMZEG00005021870.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101474403"/>
    <dbReference type="CTD" id="100537117"/>
    <dbReference type="GeneTree" id="ENSGT00940000155380"/>
    <dbReference type="OrthoDB" id="16753at2759"/>
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        <property type="component" value="LG20"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:adrenomedullin receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_2"/>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
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        <property type="entry name" value="GPCR_2_calcitonin_rcpt_fam"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF4">
        <property type="entry name" value="CALCITONIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CTRFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018286434" evidence="14">
        <location>
            <begin position="41"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="15">
        <location>
            <begin position="81"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="16">
        <location>
            <begin position="173"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Ensembl" id="ENSMZEP00005029322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="515" mass="58537" checksum="745A2561A5BF0490" modified="2019-02-13" version="1">MGIFGGEDSLTANSKKREMWKTLTLSLLVALALFTEVAHCQDMESLAVTEKTMPRQENFTNMDLADLLGQSRRQILAAQFECYLKIIHDPVTEEGPYCNRTWDGWLCWDDSAPGTVMQMCPAYFMDFDPTERVTKVCNPDGQWFHHPESKRIWSNYTMCSAHTNHKLKLAISVYYMAMVGHSLSIVSLVISLTIFSYFKSLSCQRISLHKNMFLSFILNSIVTMIWLTFSIVNNQGTDTSNSVNCKILAVLTQYTSTSTYFWMLCEGIYLHTLIIVAVFVGEQQLFWYYILGWGFPIVPAVTYAVARGLFHNDPCWISTHTQLLYIIHAPIHVALIVNFFFLLNIVRVLITKLKETHCAESTTYMKAVRATLILIPLLGIQYILIPWAPDGRISHAVYEFFLNIFTHFQGLLVASIFCFCNAEAQTAVRRKWFQCKSAWGKTGWGETPLTNNHFNYHTNSSITETSRITMNVEPSANAPSEKKDSISVVPQNASRKKSNACTNGEISNILETTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D5L7</accession>
    <name>A0A3P9D5L7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H2 subunit B family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D5L7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029391"/>
    <dbReference type="Ensembl" id="ENSMZET00005030317.1">
        <property type="protein sequence ID" value="ENSMZEP00005029391.1"/>
        <property type="gene ID" value="ENSMZEG00005021926.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011439"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.120:FF:000002">
        <property type="entry name" value="Ribonuclease H2 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Rnh202 triple barrel" evidence="11">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="10">
        <location>
            <begin position="90"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="302" mass="34334" checksum="A4C74F7AA2B35B25" modified="2019-02-13" version="1">MATKKKRTSNVDNDSWVVIAPGGTEITHFLLFSFFFLNPADAASLYMLGCGDVMLYEVKAFEDDFHSWFVGQAVQRDGRLIFVTPLDPLFLILPYLIKSGKEEKFQRVDQVVKDEEFPACSRLLSCARTLASLHHIAEEKEVESQMYHRYSQEKTMNWLKKKVERTVIALKKKNVSVGEGVKSSTYVRVKSETDNQEEDFIRYSHGLISEYITEDLSKALLTHLGLPELTSPKETEPPSKKRKLSDKPVEAGEDYTKFNSADFARKPPKKMTAAQKSLAKVDKTGMKPMSSFFSPKVKAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D643</accession>
    <name>A0A3P9D643_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 35 member C2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_012778507.1">
        <property type="nucleotide sequence ID" value="XM_012923053.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D643"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029627"/>
    <dbReference type="Ensembl" id="ENSMZET00005030561.1">
        <property type="protein sequence ID" value="ENSMZEP00005029627.1"/>
        <property type="gene ID" value="ENSMZEG00005022095.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472496"/>
    <dbReference type="KEGG" id="mze:101472496"/>
    <dbReference type="CTD" id="51006"/>
    <dbReference type="GeneTree" id="ENSGT00510000048078"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21092">
        <property type="entry name" value="TPT_S35C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="364" mass="41094" checksum="ACEEF7A2423F1011" modified="2019-02-13" version="1">MACPVQFLCRGLRTVGLVLLYYVFSIGITFYNKWLMKGFHYPLFMTLVHLTIIFCLSALTRQAVQWWTGKPRVTLRWKEYLRKVAPTAIATALDIGLSNWSFLFITISLYTMTKSSAVLFILFFSLVFKLEEPNPFLILVVLLISCGLFMFTFESTQFNLEGFILVLLASFIGGIRWTLTQVLTQKAELGLQNPIDAMYHLQPLMFLGLFPLFLFNEGLSLSTSEKLFRVTELSPLLYSLFTLSIGGLLAFGLGFSEFLLVSRTSSLTLSISGIFKEVCTLLLAAFLMGDKMSMLNWLGFAVCLCGISLHVGLKTYYTKNKGPSLRQLKSKSPELELPLLQRNGNESKDSATDECDEEEEITLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6X4</accession>
    <name>A0A3P9D6X4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Leucine-rich repeat LGI family, member 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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            <authorList>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Secreted</location>
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            <authorList>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7G6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030498"/>
    <dbReference type="Ensembl" id="ENSMZET00005031459.1">
        <property type="protein sequence ID" value="ENSMZEP00005030498.1"/>
        <property type="gene ID" value="ENSMZEG00005022725.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165785"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048593">
        <property type="term" value="P:camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030902">
        <property type="term" value="P:hindbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000069">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF44">
        <property type="entry name" value="PAIRED BOX 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="10">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="157" mass="17224" checksum="9E4015237928A562" modified="2019-02-13" version="1">IGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILLSNKDVCYYVAQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVGRIAQYKRECPSIFAWEIRDRLLAEGVCTNDNIPSVRPFCFSAKCATLPILLHLSLLQPSLIPHHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7I9</accession>
    <name>A0A3P9D7I9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="15">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="15"/>
    <dbReference type="RefSeq" id="XP_004549553.1">
        <property type="nucleotide sequence ID" value="XM_004549496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7I9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030319"/>
    <dbReference type="Ensembl" id="ENSMZET00005031272.1">
        <property type="protein sequence ID" value="ENSMZEP00005030319.1"/>
        <property type="gene ID" value="ENSMZEG00005022596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486970"/>
    <dbReference type="KEGG" id="mze:101486970"/>
    <dbReference type="GeneTree" id="ENSGT00940000162224"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000008">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="10 15" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018092607" description="Superoxide dismutase [Cu-Zn]" evidence="16">
        <location>
            <begin position="28"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="17">
        <location>
            <begin position="62"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="215" mass="23534" checksum="1B2FD0A096B717D9" modified="2019-02-13" version="1">MHRYASVGILEAALLVLLAGCQQCVLASSDTLAPEVLQNNGTLYAVCKVRPSTSLPEDLPKVYGHVLFKQDHPQEKVKVLLRFSGFPRDGSPEPRAVHIHQYGDLSRGCDSTGGHYNPYGVNHPNHPGDFGNFEPQQGKINTMLESDATLFGSLSVFGRAVVIHEKIDDLGRGGDAGSLLHGNAGRRLACCIIGVSSPNLWNMNFKQYSRRLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D824</accession>
    <name>A0A3P9D824_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">All-trans-retinol 13,14-reductase</fullName>
            <ecNumber evidence="17">1.3.99.23</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2</text>
            <dbReference type="Rhea" id="RHEA:19193"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:52075"/>
            <dbReference type="EC" id="1.3.99.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.23" evidence="17"/>
    <dbReference type="RefSeq" id="XP_004552433.1">
        <property type="nucleotide sequence ID" value="XM_004552376.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D824"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030845"/>
    <dbReference type="Ensembl" id="ENSMZET00005031824.1">
        <property type="protein sequence ID" value="ENSMZEP00005030845.1"/>
        <property type="gene ID" value="ENSMZEG00005022976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478120"/>
    <dbReference type="KEGG" id="mze:101478120"/>
    <dbReference type="CTD" id="325922"/>
    <dbReference type="GeneTree" id="ENSGT00390000017613"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051786">
        <property type="term" value="F:all-trans-retinol 13,14-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000362">
        <property type="entry name" value="All-trans-retinol 13,14-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052206">
        <property type="entry name" value="Retinol_saturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091:SF1">
        <property type="entry name" value="ALL-TRANS-RETINOL 13,14-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46091">
        <property type="entry name" value="BLR7054 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="630" mass="70167" checksum="213B297F5F2A559F" modified="2019-02-13" version="1">MEPNEEVNAVTVPSGLGRGAIMIAVSIICAAIVIFLLHYVFGGRGPDPFEKDTREPLKKRVYDKKEKNKVLKQGFVANRVPENLDAIVIGSGVGGLGLAVLLAKVGKRVLVLEQHSRAGGCCHTFTEKGFEFDVGIHYIGELLDHKPFRCMLDQMTNGQLEWEPLENPFDHVVLGPPENRRRYPIYSGRTRFTDELKKCFPGEEKAIDEFMKLAKKTGNGVWFLALLKILPLPLAKFLVHTGLLRHLSFFFKMAPRSLTDVVNELTENKDLRAVFSYIFGTYGKIPKDASFAMHSLLVTHYLNGAWYPKGGASEIAYHMIPIIEKAGGAVLVRAPVNRILFNDAKEACGVSVMKGQEEVHIHAPLIISDAGIFNTYQKLIPKDLQTMPAIQKQLSMLKHGEGGLSVFMGLNGTKEELGLKADNYWIFAENNFDELVMNYMKKDREEAAKNVPLLFVASPSAKDPTWEARSPGKSTLSLVTFAKYEWFEEWKDGKVTNRGRDYTELKQAFIDTILEVVMDVFPKITRDKIEYIDAGTPITNTHYIGAPKGEIYGADHSISRFDPELNITVRAQTPLKNLYLTGQDVFLCGFAGALAGALTCGSAILKRNLHLDTIALAKRTAFINTKLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D907</accession>
    <name>A0A3P9D907_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SH3 and cysteine-rich domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">24b2/STAC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Src homology 3 and cysteine-rich domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domains) with CACNA1S. Interacts (via SH3 domains) with CACNA1C. Has much lower affinity for CACNA1C than for CACNA1S.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D907"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030606"/>
    <dbReference type="Ensembl" id="ENSMZET00005031570.1">
        <property type="protein sequence ID" value="ENSMZEP00005030606.1"/>
        <property type="gene ID" value="ENSMZEG00005022801.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183092"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000073">
        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000022">
        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF5">
        <property type="entry name" value="SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16664">
        <property type="entry name" value="STAC2_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 17" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="79"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="234"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="351" mass="39421" checksum="C2CB20B034F2531F" modified="2019-02-13" version="1">MSVDVCPWVQLQRLKRSLSFKTMMRSKSVENFFQRSYSDARLPQDFITDPPPNPSISSHSPSLSLSPSLPAKPPRPQITHCFQDHIFRKPTNCQHCKHMIVGNSKQALRCKTCKMAAHLWCTSELSQQPCHGKVRNTHTKKAPRMRVDPVYAALRYGTSLAQMSRSSFGSLSESPTRSLQRTNSDCRGEGTALSNPPVHTFIPCCSIPQACISVSLPPLPASPCNQVPKRIEVHSIHTYVALYKFLPQEPNDLELHPGDRVQVTDDSNEEWWKGKCGDKVGFFPANFVQRVRPGERVWRVIQGNPGNRERGHMAVRESQICVGKREEGEVFLKLSSGKKKGLVPADSIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9E9</accession>
    <name>A0A3P9D9E9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synembryn</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein Ric-8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9E9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030751"/>
    <dbReference type="Ensembl" id="ENSMZET00005031729.1">
        <property type="protein sequence ID" value="ENSMZEP00005030751.1"/>
        <property type="gene ID" value="ENSMZEG00005022908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014700"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008376">
        <property type="entry name" value="Chaperone_Ric-8_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF3">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01802">
        <property type="entry name" value="SYNEMBRYN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="521" mass="58982" checksum="0E33DD1690F61893" modified="2019-02-13" version="1">MVPDIERIIESIVRRDQDSVQLLLNSYNTQVTILCYNYCVAIEDLSAALLCFIGSQLQPAVLRVCLHTLRILSRDRRALGHMVTDSALLTLAHMGGIAIPQTCLQQENQEAEGDVGLWESLKEEIWSKVPLSCHFYKLRLLFLLTALRPELRLQLQQERGVSLLTKALEQCLAVSWGVEYEVLTDSKQPPISMEVSQKVIEILKTLFNITHMFHRQEPDEEDAALYRHLVAVLRHCLLLSCEGEDTLEELQGHTVNVLSALPLTCLDVLVSVQVDQASHKCEGVNMDCVHKLLLFMNRRLNRGQKLKEKLTPVLNLLTESSRVHRETRHYIRQKILPPLRDVAIRPEQDSSLRGQLVRLMTHVDTDVKDCAAELLFVLCKENVSRFVKYTGYGNAAGLLAARGLLNGRMSSSNSQYSSDSDSDTEEYREAKAKINLVTGRVEADQPDPMEGMTDEEKEEEARHLISMINRLSREQIIQPMGVTAEGRLAPLWGQMSDCTLEEEEEEELNLMPEGGKDSQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9Q0</accession>
    <name>A0A3P9D9Q0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear GTPase SLIP-GC</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004559415.2">
        <property type="nucleotide sequence ID" value="XM_004559358.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9Q0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031430"/>
    <dbReference type="Ensembl" id="ENSMZET00005032450.1">
        <property type="protein sequence ID" value="ENSMZEP00005031430.1"/>
        <property type="gene ID" value="ENSMZEG00005023431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473846"/>
    <dbReference type="KEGG" id="mze:101473846"/>
    <dbReference type="GeneTree" id="ENSGT00390000007091"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053082">
        <property type="entry name" value="Nuclear_GTPase_SLIP-GC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47308">
        <property type="entry name" value="NUCLEAR GTPASE SLIP-GC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47308:SF1">
        <property type="entry name" value="NUCLEAR GTPASE SLIP-GC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="165"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="804" mass="91831" checksum="FB03B9ABB04381A1" modified="2019-02-13" version="1">MDDFVRNKLTEWKLSEWIEAFEAQEIDEESLYHLDDQEINQLITKAGPRVKFNNKLKLLKEEQNTTQPQKQAVNISVEDSPSKSEKEIQKRKRKSDHLQGEFSQWQPAPKQQYNCTAGSQSETEILSDVKDIMKHVSEGLHGRDKLSAFLKDKTKDLETEKRHLVGVFGKTGAGKSSLINAIINKKGLLPSGSVSACTSVMIKVEATSGSKYEAHIEFITKEDWKSELKSLKEVLEDNDDNDDDDDDDDDGGGGNDDFFDADEKLSALYGEEWKERSPHNLMDNKYFIDIPEFRTSKTKILKSDSAEGLSEKFVKYTRSESNETEEVKRWYWPLVKCVTVKVPDNDFLDHVTLVDLPANGDSNRSRDRMWTGFVASCSAVWIVTEMNQAASEKEAWEILENASSLLGNGGECQQIHFICTKSDHENPDDLKKIKSAVMNEFKRRKLIKNHFSEDSFKVFTVSSTEFLKGENANPDHNEIPKLKEILKNLNDTHSETLNYVSGAYGILSLIQGATIREVVEQKNDLYDLLEGKLFIQLNQVKKAIEKIIKAFEQRLSEGVEKSQNLCEKKLKSFLHPSKMSDGAFHRTLKSAVRNDGIQKPKKGKPKNLNVTLASYLTESIDEKFRKTFPNDVKCGHFNGAIDAFSLSTDSLIEKYKDVELQLIFLQTEEKKIKAKLNKTILTQKKLIYNSLTETIKDNMKKCYREAAAFEGRGTLKKMRHTIERHVHSRKYMFEEAKNAMLEQLSDLKETVLRTLENTMKESIDFSLKTETCSLPDVSDHLQVVKKHYDELNGGQDEKKTNHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D9W2</accession>
    <name>A0A3P9D9W2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acid-sensing (proton-gated) ion channel 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D9W2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030892"/>
    <dbReference type="Ensembl" id="ENSMZET00005031873.1">
        <property type="protein sequence ID" value="ENSMZEP00005030892.1"/>
        <property type="gene ID" value="ENSMZEG00005023005.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154991"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048545">
        <property type="term" value="P:response to steroid hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.820:FF:000001">
        <property type="entry name" value="acid-sensing ion channel 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3590.10:FF:000002">
        <property type="entry name" value="acid-sensing ion channel 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3590.10">
        <property type="entry name" value="acid-sensing ion channel 1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004724">
        <property type="entry name" value="ENaC_chordates"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00859">
        <property type="entry name" value="ENaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF128">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="561" mass="63504" checksum="BBD403B5ADF9FE8F" modified="2019-02-13" version="1">MWAPALEAWLGNEAFPAALGALWTAMALEGRCLRRGSPAMIRKGRQRLHPKPTLAQVTSTLLSRTRLHGLRHICVPGGSVGRRAFWLLALCTSVGLLLSWSSNRLLHWLSFPTYTRVHTEWAKELAFPTVTICNNNPIRLYKLTKSDLYFAGHWLGLLLANRTVRPMVLDLLQEDRRTWFKKLSDFRLFLPPRNFEGTNLEFMDRLSHQLDDMLLSCKYRGEPCGAHNFSSVFTRYGKCYMFNAAEEGKTLRTTMKGGTGNGLEIMLDIQQDEYLPVWGDTEDTAFEAGVRVQIHSQAEPPFIHELGFGVAPGFQTFVATQEQRLTYLPPPWGECESKALESGFFQVYSVTACRIDCETRYIVENCNCRMVHMPGDASYCTPEQYKDCAEPALGKSNLLFEKTFSNCMCRTPCNMTRYNKELSMVKIPSKTSARYLQKKFNKSEKYITDNILVLDVFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASILTILELFDYAYEVVKDRLLDLLSREEEEESHGEDVSSCDPVANHSESISHTVTVPLQTTLGTLEEIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DB21</accession>
    <name>A0A3P9DB21_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DB21"/>
    <dbReference type="Ensembl" id="ENSMZET00005032924.1">
        <property type="protein sequence ID" value="ENSMZEP00005031890.1"/>
        <property type="gene ID" value="ENSMZEG00005023790.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286922"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="88" mass="10136" checksum="5849D2DEDA427C42" modified="2019-02-13" version="1">MAQKGVQLESETISCSICLDFLKDPVTTACGHSYCRNCIKSFWDEEDRKGIHSCPQCRKTFTPRPVLEKNIMLAALVEHRRAQIRTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEL8</accession>
    <name>A0A3P9DEL8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein</fullName>
            <shortName evidence="8">Cnt-b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Centaurin-beta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endosome membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004565070.1">
        <property type="nucleotide sequence ID" value="XM_004565013.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004565071.1">
        <property type="nucleotide sequence ID" value="XM_004565014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DEL8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033135"/>
    <dbReference type="Ensembl" id="ENSMZET00005034238.1">
        <property type="protein sequence ID" value="ENSMZEP00005033135.1"/>
        <property type="gene ID" value="ENSMZEG00005024717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467947"/>
    <dbReference type="KEGG" id="mze:101467947"/>
    <dbReference type="GeneTree" id="ENSGT00940000156389"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08835">
        <property type="entry name" value="ArfGap_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07603">
        <property type="entry name" value="BAR_ACAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13250">
        <property type="entry name" value="PH_ACAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000007">
        <property type="entry name" value="Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000025">
        <property type="entry name" value="arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000384">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF402">
        <property type="entry name" value="ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="263"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="11">
        <location>
            <begin position="394"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="556"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="701" mass="78426" checksum="000D0B47DC9ED7CC" modified="2019-02-13" version="1">MDCLLDFEDCVKDSPEFRLALDQFETDVSQLETKLDKVMKLCGKMVEAGQAYSTANKLLLSGLAELCTNQTKDSVITTCLNQFHQGLQEMVSFHTMLFDQTQRAIGQQLTNLCTQFLPQLAETRKEFVRIGEDLETAATKNAQVSRHKAADAERASHLLLATRKCYQHFALDYCLQLNTFKTQQKVDILNSMFSFVHAQFTFFHQGFDLLRDLEPTMKTMAAQLSQLSADCTAKRKELENRHLLVQQRDASGEPMVSACPGNDDIIRGYLFKRSRRKSKMWKRSWFTIRDNQLIYRKSHKEEAVVLFEDLRLCAVKSLDHVDRRFCFELLSVQKCCALQADSEQLKQAWLSALQGSIDLAYRERSDTQLTQPKELPPLHCGGDVCPGPPAQRPAALSVALRGLGNQRCCDCGEEEPRWASINLAVTMCIECSGIHRSLGVHLSKVRSLTLDSWEAEQLKLLCVLGNDVMNQIYEARCSEEGRVKPRADSPRAEKEAWIKEKYVEKKFVQANGAQHHRHKDSAMLRLYQASLAGDLVAMASMLAEGAEVNGSVGEEEGRTPLIGAAIGGSLLACEFLLQNGANVNHRDLRGQGALHAAATAGHTGQVCLLLKRGANQYAVDERGHDPLAIAVETANADIVTLLRMARMNEEMRDSEGVFGAAGDDETFQDIFRDFSDMASHDPERLSRRHFSRGGAEEEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFS0</accession>
    <name>A0A3P9DFS0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="RefSeq" id="XP_004542852.1">
        <property type="nucleotide sequence ID" value="XM_004542795.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023010341.1">
        <property type="nucleotide sequence ID" value="XM_023154573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFS0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033545"/>
    <dbReference type="Ensembl" id="ENSMZET00005034694.1">
        <property type="protein sequence ID" value="ENSMZEP00005033545.1"/>
        <property type="gene ID" value="ENSMZEG00005025062.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463880"/>
    <dbReference type="KEGG" id="mze:101463880"/>
    <dbReference type="CTD" id="4173"/>
    <dbReference type="GeneTree" id="ENSGT01150000286951"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001878">
        <property type="term" value="P:response to yeast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="15">
        <location>
            <begin position="454"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="860" mass="96086" checksum="9273C6CB5523CD18" modified="2019-02-13" version="1">MSSPASTPGGRKRGRNTNPPTPSSEDPTSPPSQRRRGQDSSTGDLMPMPTSPATDILSPAAPQDTSLLSSPRPSVPPNEVDMSSPLMYGTPSSRIEGTPRSGVRGTPARQRPDLGSVRKAPQVDLHSEPPSADGAVASESNAGQRLVIWGTDVNVGTCKEKFQRFLQRFVDPTSTEDENAGLDLNEPLYMQKLEEISVVGDPVMNVNCRHVQSFDAELYRQLTCYPQEVIPTFDMAVNELFFERFPDSFLEYQIQVRPYNAVKTKSMRSLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAYSTRVEVDRGRIAEPAVCRHCNTTHSLALIHNRSVFSDKQMIKIQESPEDMPAGQTPHTTIVYAHNDLVDKVQPGDRVNITGIYRAVPMRVNPRQSNVKSVYKTHIDAIHFRKTDEKRLHGLDEEAEQKLFTEDRVQTLKELAAKPDVYERLSSALAPSIYEHEDIKKGILLQLFGGTRKDFSQTGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTAVLAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQTEEQMEEEFLDMAVLKDYIAYARTYINPRLSEEASQALIEAYVDMRKIGSGRGMVSAYPRQLESLIRLAEAHAKVRFSEKVETIDVEEAKRLHREALKQSATDPRTGFVDISILTTGMSATARKRKEEVAQALKKLIQAKGKTPAMKYQQLLDDLRGQSETAITKELFDEALRALADEDYLTVTGKTVRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DH00</accession>
    <name>A0A3P9DH00_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M12B propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DH00"/>
    <dbReference type="Ensembl" id="ENSMZET00005034531.1">
        <property type="protein sequence ID" value="ENSMZEP00005033401.1"/>
        <property type="gene ID" value="ENSMZEG00005024936.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156647"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M12B propeptide" evidence="2">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="166" mass="18229" checksum="40AD9B818F984ADC" modified="2019-02-13" version="1">RLGNVSHPDHISSNPHCVCVCAHIPWGHFYKLGTFTCNAAGVTDSSSSSADSLHQVLSEFAIIRPIRTDSEGRFLSGSISARQLHRRKRHEAELFYNVTAFGKELHLHLHPNSRLVAPTATMEWEESGQHHSQPIEDTGCFYTGTVSNMEGTSVAISNCDGLVCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHK0</accession>
    <name>A0A3P9DHK0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHK0"/>
    <dbReference type="Ensembl" id="ENSMZET00005034778.1">
        <property type="protein sequence ID" value="ENSMZEP00005033606.1"/>
        <property type="gene ID" value="ENSMZEG00005025125.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286952"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000875">
        <property type="entry name" value="zinc finger protein 236 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001134">
        <property type="entry name" value="Zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="282" mass="32431" checksum="D0850F33D405B551" modified="2019-02-13" version="1">MSATKTYTHVLQNHLVTHSGIKPYTCDQCGKAFTQSSHLQRHLVTHSGIKPYSCDECGKGFTVRAKLKQHQVIHTGESPFSCDLCGKSFSSKGSLKTHQLIHSGVKAYSCDQCGRAFTRSSHLQSHLVTHSGIKAYSCDICGKTFSQRGSRNTHLRIHTRHDVYCCEQCGKYFTTDAQLQQHMFTHTEERPYRCDLCEKTFKAPHHLRRHQQIHTRKRLYKCIYCERSFSQSGHRNSHERVHMEGNYSCDQCDKSFRNLSSYSAHKRSHVTNKLKNVLETHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DK78</accession>
    <name>A0A3P9DK78_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="protein sequence ID" value="ENSMZEP00005034561.1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="181" mass="21879" checksum="344225803D337BF6" modified="2019-02-13" version="1">KEPPKRRPAEREVTQTGSFNIPRLNPLHPPFVHKRTVSLETPDVHQHNHQRTLIMQRKEHYRYHQVWRKPFYGTSSEREEYRKELREQLKRQIEEKCAAIKLQLANKIKEAETLREADRLDLASEREQRIQHSKAMAVYRDENKRLMEQSWRDRALTRSQEALNERELLRLNPINWSGTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLL0</accession>
    <name>A0A3P9DLL0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chromatin modification-related protein MEAF6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
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                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="8 9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLL0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035213"/>
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        <property type="gene ID" value="ENSMZEG00005026320.1"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
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        <location>
            <begin position="108"/>
            <end position="185"/>
        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
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            <begin position="119"/>
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        </location>
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    </feature>
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            <end position="177"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035213.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMQ2</accession>
    <name>A0A3P9DMQ2_9CICH</name>
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        <submittedName>
            <fullName evidence="3">Spermatosis associated serine rich 2</fullName>
        </submittedName>
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        <name type="scientific">Maylandia zebra</name>
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            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Malinsky M."/>
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                <person name="Simakov O."/>
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                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
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                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the SPATS2 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="UBA-like_sf"/>
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        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15623">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="98"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="494" mass="54011" checksum="62240CFBD7712422" modified="2019-02-13" version="1">MAKKNSQKDTSGVVFDTRSKMVMSQGGTAERMKEKISAVRAVVPNKSNNEIVLVLQHFENCVDKAVQAFLEGSAAEILKEWNVTGKKKPKKKKKPKPQPEAPAEPAPPEATSPEEGKDELNGFHANGSVMDGESLDSLSEHLDSASLDAAELDSEPATSETTGAEAESQGSAPSPTSQPGGRNHQAPRGNKSRQRPNSNSYHPPASLASNTDEQGSSGVKKMASNIDRSVKDLQRCTASLTRYRMVVKEEMDSSVKRMKQTFAELQSCLMDREVTLLAEMDKVKADAMMILDARQKRAEELRRLTDKSASMSEEQLTELRADIKHFVSERKYDEDLGKALRFTFDLEPLKTSIAGFGSVYHPRTGYSNRSRCSSTSSSVASPTLPETPAPTQIQSNHPSETRPPPAKQIFQGNRRTFHGQGYHTGGQRYNGGSYNDRNAGRANHRHQNDGASSGPTSQHSNNSRGPSHSSTSSHNQDRPSHNGLPQRVPRTHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMR9</accession>
    <name>A0A3P9DMR9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMR9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035497"/>
    <dbReference type="Ensembl" id="ENSMZET00005036750.1">
        <property type="protein sequence ID" value="ENSMZEP00005035497.1"/>
        <property type="gene ID" value="ENSMZEG00005026521.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157890"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004086">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="330" mass="35664" checksum="058E99BC5D1A56D7" modified="2019-02-13" version="1">GHDQSDCTAVFSCFICQLCPLYFWFPLGMWTCPTCDKKYLTEYMLQKHVHLTHEKVEAQSCHLCGTKVSTRASMNRHLRRKHPEVVSVRIDEFDDLQENLSMNDSSISIVSPVDLPDTPRRSREAQLSRSSLSPMNTLILLNQGIVGDETEMSSAVQSIQQVVVLTDPSAPSASSPNSSVGLANITVTPITSHAPAQFTSLQPVAVGHLTASDRPLTLDNSILTVTFDTVSGSAMLHNRSAELIPETVGSAGSRTPQSVAHFINFATLVNPMGHQLEAPTLAWRPVPAAEGSQVTPVVEGAHGESQEAQIQAGPARASHAICTANHAWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNK2</accession>
    <name>A0A3P9DNK2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gonadotropin subunit beta-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTH-II-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Gonadotropin beta-II chain</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in gametogenesis and steroidogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycoprotein hormones subunit beta family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNK2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036365"/>
    <dbReference type="Ensembl" id="ENSMZET00005037641.1">
        <property type="protein sequence ID" value="ENSMZEP00005036365.1"/>
        <property type="gene ID" value="ENSMZEG00005027133.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158152"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010817">
        <property type="term" value="P:regulation of hormone levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00069">
        <property type="entry name" value="GHB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000007">
        <property type="entry name" value="Luteinizing hormone beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006208">
        <property type="entry name" value="Glyco_hormone_CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001545">
        <property type="entry name" value="Gonadotropin_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018245">
        <property type="entry name" value="Gonadotropin_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515">
        <property type="entry name" value="GLYCOPROTEIN HORMONE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11515:SF29">
        <property type="entry name" value="THYROTROPIN SUBUNIT BETA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00007">
        <property type="entry name" value="Cys_knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00068">
        <property type="entry name" value="GHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00261">
        <property type="entry name" value="GLYCO_HORMONE_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0372">Hormone</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glycoprotein hormone subunit beta" evidence="12">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="151" mass="17186" checksum="5ACE9BFB1AEDE715" modified="2019-02-13" version="1">MSSGSFYLMPLFALKSLLLCVLMVGAVYTCMLKNYTLWIEKQDCTQCVAINTTICSGYCYTQDTNLRGRFGRTFLIQRSCVPLSLVYRAAHIPGCPKDVNPQLYYPAAHCCSCRRCDTRTHRCVRTSLHLMFCSLVYYDIAIKQSVHAIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNP9</accession>
    <name>A0A3P9DNP9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TAFA chemokine like family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TAFA3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAFA family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNP9"/>
    <dbReference type="Ensembl" id="ENSMZET00005037678.1">
        <property type="protein sequence ID" value="ENSMZEP00005036400.1"/>
        <property type="gene ID" value="ENSMZEG00005027166.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101475964"/>
    <dbReference type="GeneTree" id="ENSGT00940000155644"/>
    <dbReference type="OrthoDB" id="9924724at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020350">
        <property type="entry name" value="Chemokine-like_TAFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051743">
        <property type="entry name" value="TAFA_chemokine-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31770">
        <property type="entry name" value="CHEMOKINE-LIKE PROTEIN TAFA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31770:SF3">
        <property type="entry name" value="CHEMOKINE-LIKE PROTEIN TAFA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12020">
        <property type="entry name" value="TAFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018017671" evidence="3">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="128" mass="13994" checksum="7DCF6CA026FC8F47" modified="2019-02-13" version="1">MRERGPCICGVGVWSLLLSLCLASLTHAHRSHTVHVKAGTCEVIAAHRCCNKNKIEERSQTVKCSCFPGQVAGTTRAMPSCVDASIVAQKWWCQMQPCMEGEECKVLPDLTGWSCSTGNKVKTTKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPY4</accession>
    <name>A0A3P9DPY4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DPY4"/>
    <dbReference type="Ensembl" id="ENSMZET00005037802.1">
        <property type="protein sequence ID" value="ENSMZEP00005036519.1"/>
        <property type="gene ID" value="ENSMZEG00005027253.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166295"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28819" checksum="1AD8E1DD2F07C7DB" modified="2019-02-13" version="1">WDVKNFKLRNYITPKFGVQTLRYLKLGNSHTRHLRRDPGPAPYYIYILVSNLIQLCAPVLWLAKLEDHHQPTGVSAVFVFFGVTTSLNFKTCIVLERYFFVTCPMLNFIRQTKGSILVSVLIWTVCVITISVIILLHQHERIFVFTFYPAPLFILCLAGTLKALPAATSVPAEEKRRIIGTLFLLHLNYFVLVLPAVILLSFVRNVSLAMILLSPFVDLMLFCFMQKGPVDSLLSCLCCCSMNNTAADVSSRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTM3</accession>
    <name>A0A3P9DTM3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized LOC101473501</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004571295.2">
        <property type="nucleotide sequence ID" value="XM_004571238.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTM3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037809"/>
    <dbReference type="Ensembl" id="ENSMZET00005039148.1">
        <property type="protein sequence ID" value="ENSMZEP00005037809.1"/>
        <property type="gene ID" value="ENSMZEG00005028208.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101473501"/>
    <dbReference type="GeneTree" id="ENSGT00940000169105"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="418" mass="47296" checksum="FE9C0E309D5E94F4" modified="2019-02-13" version="1">MSDTYFEILRRSCSSGNYIPSGRQLPRTPPLTNVTRQLDFTNLEEPEQNMEDGVRDKDEGNQKSQTDTEELPESHDPHSMLKGMKGYQLTAADLEFLKKMKEEQLVKKMQVKLEEVQKLLKTEMVALELACASKMKAEAELKRFPSCIEVTEWAKVVLRMACPQADLTNADAKSLLSMMKIRDIQDAMDKKRVELYQIEKMVANKRKEEAEERGQMERQIANKQLRIQGLMRQLSDLKAELAQREEACTSLEMQVNITEAPEIKEDLDAIKSQMKLPRKRQKKAVKSTEMLQDAKNTSKSTRSRNRDTLKTSAEEPTRSGAPGEQQKKKVKASRGENEEAEGQDLNSRESVQPVRGRRKPAGTAQTTVSQQKSQSKVKTGEPEVPSRGRRAAATTADNAGEEAQNEGLRRSKRIASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DUJ3</accession>
    <name>A0A3P9DUJ3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DUJ3"/>
    <dbReference type="Ensembl" id="ENSMZET00005039341.1">
        <property type="protein sequence ID" value="ENSMZEP00005037942.1"/>
        <property type="gene ID" value="ENSMZEG00005028369.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278447"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF14">
        <property type="entry name" value="BUTYROPHILIN SUBFAMILY 2 MEMBER A2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018223788" description="Ig-like domain-containing protein" evidence="12">
        <location>
            <begin position="27"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="189" mass="21820" checksum="9846DCD44F55B2A1" modified="2019-02-13" version="1">MTYSIYHMSMELMCCFVLFSVVQVTAEPGDESVVLTCRSTVQPDGAKVVWKDRNERKVHVCQKDSEQPEKQHRRYRNRTEMKKEPLRTGDLSVTLKHPTNTDRDTYTCTVYSREGKELMEKQVELKIKGQCCRYRGLDIVIDSYFVTVRVFVCHTPAVQQLCYSDEHRGHLCSSCQTSLGLPVCSLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DV02</accession>
    <name>A0A3P9DV02_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DV02"/>
    <dbReference type="Ensembl" id="ENSMZET00005039561.1">
        <property type="protein sequence ID" value="ENSMZEP00005038153.1"/>
        <property type="gene ID" value="ENSMZEG00005028531.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044904"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="61"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005038153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="438" mass="50470" checksum="B3A25F0CA0A21376" modified="2019-02-13" version="1">TTPQGAADHQVEKKRISVSLSPGGKARHLFHRRNPPQEQFSIQKKPWPVNRQEKRPNKPNRTILLVGETGAGKSTLINALLNYTMGVKWEDEVWFMIAEEERRSQTSDVMVYEIFGFEDETLPYSLTIINTPGYGDTRGIEHDDIISHRLLDLFQSEDGVHEVHAVGLVMKASVNRLSEPLRYVFDSVMSLFGKDVEKNIVALITHSDGTTPKNALKALEAAKIKWAKNESNEPVYFLFNNCQHEERMEENTIFRNSWELTQTNMDHLTDLLGKSNPQKLVKTAEVLNERIRLKACIQNLEDRFELAELKQTEIREIREALKQTNHRNKIEIEKILSLLENLEKEMKVLTAEKEKWLSDSYQHAVRLQEIALKANSASTVAHLDFLIEKMKEEGDTEKVQKLEEMRREDGGTKESQRYKLGQTTSAIKNIGRSFPWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AR87</accession>
    <name>A0A3P9AR87_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rabenosyn, RAB effector</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004546176.2">
        <property type="nucleotide sequence ID" value="XM_004546119.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004546177.2">
        <property type="nucleotide sequence ID" value="XM_004546120.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AR87"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000170"/>
    <dbReference type="Ensembl" id="ENSMZET00005000210.1">
        <property type="protein sequence ID" value="ENSMZEP00005000170.1"/>
        <property type="gene ID" value="ENSMZEG00005000219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481902"/>
    <dbReference type="GeneTree" id="ENSGT00390000007159"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15716">
        <property type="entry name" value="FYVE_RBNS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16601">
        <property type="entry name" value="NPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="160"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="783" mass="89436" checksum="CB279D4821F1A213" modified="2019-02-13" version="1">MASSYPPPFEGTGEVKEGFLCPLCLKDLQSFYQLQDHYEEEHSGDDRHVRGQLKSLVQKAKKAKDKLLKRDGDDRPDTGSYESFYYGGVDPYMWEPQELGVTRSHLDLFKKHRAARIDHYVIEVNKLIIRLEKLTSFDRANSDAAKIRAIEKSVVSWVNDSDVPFCPDCGNKFNIRNRRHHCRLCGSIMCRKCMEFVPLPLAQKLIAGTREALCVPGSPSQSQSPPAGGGSSGMGSRRGSISSLSSVTSMLEEKDDEKIRCCHHCMDTLLKRQQKLEEKDHVPDIVKLYERLRMCMEKVDEKAPEYIRMAESLNAGETTYNLDTAGGLRLEVQKYYELIDALSKKILTLGLKDDPQPHPKVLQLQKMIRYTATLFVQEKLLGLMSLPTKDKYEELKEKRKREQEKRLQQERLAAQEALKRRQERQERSRPPVNANGELPQTPREPRITKAGGWLPSADSVHTRGELEDPLLQQIENIQSFLRQAREAQRTDEVAMLEENLRQLQDEYDQQQTSIALALSEKLAQEESLQQGELHRLKTWEREEKEQWSSAVNSFEPSYKWERSLDITPTGGHQGEEDIPAEELTPKAERSPPSFRAFPALTSQEESPPRLRSLGGHVTPPGGEGQNNTSLNPFEEDDSTPTEDDPSNPFFEDIKKDHKEVTNGKKEYNPFDEDEDAEEDKQAETVSRNPFEDDDTDEGNPFLEASGNSPEVSTNPFDGDDKDEVLPDVDMIEEELLLQQIDNIRAYIFDAKLSGRLDEVDLLTQNLKELQKTLQEQKNKNKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARE4</accession>
    <name>A0A3P9ARE4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Matrix remodeling-associated protein 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004545159.2">
        <property type="nucleotide sequence ID" value="XM_004545102.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARE4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000274"/>
    <dbReference type="Ensembl" id="ENSMZET00005000330.1">
        <property type="protein sequence ID" value="ENSMZEP00005000274.1"/>
        <property type="gene ID" value="ENSMZEG00005000310.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479396"/>
    <dbReference type="KEGG" id="mze:101479396"/>
    <dbReference type="GeneTree" id="ENSGT00390000001509"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042472">
        <property type="entry name" value="MXRA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44793">
        <property type="entry name" value="MATRIX REMODELING-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44793:SF1">
        <property type="entry name" value="MATRIX REMODELING-ASSOCIATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018010154" description="Matrix remodeling-associated protein 8" evidence="14">
        <location>
            <begin position="32"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="181"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="434" mass="50224" checksum="5D70299311897C9D" modified="2019-02-13" version="1">MKTKRDDIIFQTLLLIHIPVACFFTAVSCQAESSSVVVAGYNVSSRAGSKLVLQCVSSRMVWTRDRVRDRQRVIHWDMYRAYPDYAMERVVDMFSAGEQRMYNSYNLGRVGLNPTAFKDGNFSLVIKDVTMNDRGLYSCNLHHLYCNFYETVRVQLNVTKSRRKEQRYWNGHNAVFVVLLGSTAVLPCTNRRSVWTDWSDQEEDQQVVHWDRQAPGISHDRADRLVDLYASGEQRSYGPLFLQRKMNISNHAFSEGDFSLTISDLQPADQGLYSCHLHHHYCGLHERRVFQVTVEPSLVKPTMPAKSLPSEDKETAKAESPRVITVILPEQRHHFLLPLGYVLTSFLLLAFVVLIIVVILRRRTTKEMYPQSYMGPSRSQSCSDEFEMDVTEVNVCSPEERRFDYKNNLLKEKAHVKTQPKFIDLDKEMQKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATW6</accession>
    <name>A0A3P9ATW6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-binding cassette, sub-family C (CFTR/MRP), member 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005001165"/>
    <dbReference type="Ensembl" id="ENSMZET00005001253.1">
        <property type="protein sequence ID" value="ENSMZEP00005001165.1"/>
        <property type="gene ID" value="ENSMZEG00005000888.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164383"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000007">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF176">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="294"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="88413" checksum="0A4669A57B3620ED" modified="2019-02-13" version="1">ESFCFKLLEDVLTFVSPQLLKLMISFTQDKSRYAWEGYLYAVLLMVVALLQSLTLQQYFQRCHVLGMKVRTALMAAVYKKALVVSNDTRKESTVGEMVNLMSADAQRFNDVTNFIHLLWSCPLQIIISIVFLWLELGPSVLAGLGVMVLIIPTNAVLATKARKLQIENMNFKDKRMKIMNEILNGIKILKLYAWEPSFQKQVEDIRGEELKVMKKSAYLHSFSILTSCCIPALVSLATFAIFVSVSNDNVLTAERAFTSIALFNILRAPLAMLPMLIASIVQTAVSKKRLEKFLAGEDIDSDIVRQDPSFSMFTIRICTCSTPGRLVAVVGAVGSGKSSLMSALLGEMHSTKGFINIGGSLAFVPQQAWIQNATLKDNILFGSPHEEENFKKVIQACALAPDLELLPGGDLTEIGEKGINLSGGQKQRVSLARAVYSQADIYLLDDPLSAVDSHVGKHLFENVIGPNGLLKDKVCNGVISEVGSYENLRASGGTFSKFLDTYATEQSNQRNSETDEAIPASLRSCLLCLMSVLGTVFVICMATPFFAIVIIPLALIYFFVQVTLLYCRFKTAAPAGLVTIDENLKNGWPYVFCWKPGVFLLLFAVISRDSIDSNVVGLSVSYALNVNPQLVMTTSALETNIVAVERVNEYTQLKNEADWVTDTRPPQIPELDLVLHGITCDINSTEKVCVCERERESLHICINDLVPVIGRSSLCGTKVFCYGLSALLPYTSFCFSHCPSCILLGLSYLSAPLSPTGINHPVATAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSCLCGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVW1</accession>
    <name>A0A3P9AVW1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma</fullName>
            <ecNumber evidence="13">2.7.1.149</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylinositol 5-phosphate 4-kinase type II gamma</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:55993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:55965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12280"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57795"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.149"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:12281"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
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    <dbReference type="EC" id="2.7.1.149" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVW1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001764"/>
    <dbReference type="Ensembl" id="ENSMZET00005001859.1">
        <property type="protein sequence ID" value="ENSMZEP00005001764.1"/>
        <property type="gene ID" value="ENSMZEG00005001433.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000156890"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:1-phosphatidylinositol-5-phosphate 4-kinase activity"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Phosphatidylinositol 5-phosphate 4-kinase type-2 beta"/>
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        <property type="entry name" value="2-Layer Sandwich"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
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    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF35">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE TYPE-2 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="18">
        <location>
            <begin position="35"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036478"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036698"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00036950"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00039039"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041993"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="411" mass="47192" checksum="C1D241ED68581936" modified="2019-02-13" version="1">MSSPSATSNPLNTLAPKRKTKKKHFVQQKVKVFRASDPVLSVLMWGVNHSVINDLSQVPVPVMLLPDDFKASTKIKVNNHLFNKETLPGQFKFKEYCPQVFRNLRERFGIEDQDFQVSLARSPPLRHDEGKYAGLLLTSYDRTLVIKEISSEEVAEMHNALSAYHQHIVTCHGSTLLPQFLAMYRVTVESEDTYLLVMRNMFSHRLHVHRKYDLKVILQRQCISYDSVKELPTYKDVDFMNNMQKVYVSDEEKEKIMDKLNRDTEFLVRMRIMDYSLLLGIHDVERAEMEEEEEEMELSDEEEEDDENGLAPAPHSTSPEGITGYMNSFKPMGPGDFDPYVDVYAIQSAVGAPRREVYFMGLIDVLTQYDTKKKAAHAAKAVKHGAGAEISTVHPEQYAKRFKEFIAKIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZY1</accession>
    <name>A0A3P9AZY1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tissue factor pathway inhibitor</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004572607.2">
        <property type="nucleotide sequence ID" value="XM_004572550.5"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9AZY1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003240"/>
    <dbReference type="Ensembl" id="ENSMZET00005003370.1">
        <property type="protein sequence ID" value="ENSMZEP00005003240.1"/>
        <property type="gene ID" value="ENSMZEG00005002518.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101484859"/>
    <dbReference type="CTD" id="10653"/>
    <dbReference type="GeneTree" id="ENSGT00940000160348"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000004">
        <property type="entry name" value="Tissue factor pathway inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47247">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47247:SF1">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07502">
        <property type="entry name" value="MANEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018071980" evidence="9">
        <location>
            <begin position="28"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="246"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="10">
        <location>
            <begin position="319"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="450" mass="49286" checksum="A079721F1EB88485" modified="2019-02-13" version="1">MMTGGATIPLIPLKLLALGLVLASGLAMDCSWNQSTDPKQVPDFEAGGARLLSNVMELDPKSCRAMCCALPDCDLAVIGFPTDGPTHCKLVGCGDGHDACALRPSSQFEVYRKLVAEKADGDAQEGGQEENNMPQVQRWEPRSNGSNNIRCRLPMKVGPCRAAFPRFFYNVTSGNCSGFVYGGCEANRNHFESQEECEATCSGVTGPVLPDESTPAPPPVKAPRMAPNVLVESDPESADFDKSEYCEAKPETGPCRASLRHWYYNRETGNCEMFMYGGCRGNKNNYPTRESCMQTCTVSVLPSSKKSADEDSSDNKGMCTEKPDSGPCRAAFTMFYYDLDSASCRPFIYGGCRGNYNRYGSEDECMSSCSGGRLDFHDKVQNHWTAAFFLFVTLTSISALLLATLIIITLRRHRLSRRRSSSDKEELLPDEQASVDSLPLPESPKLDQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B1L4</accession>
    <name>A0A3P9B1L4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Selenoprotein H</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B1L4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003622"/>
    <dbReference type="Ensembl" id="ENSMZET00005003775.1">
        <property type="protein sequence ID" value="ENSMZEP00005003622.1"/>
        <property type="gene ID" value="ENSMZEG00005002790.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163832"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052674">
        <property type="entry name" value="SelWTH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33638">
        <property type="entry name" value="SELENOPROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33638:SF1">
        <property type="entry name" value="SELENOPROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14864" checksum="ADAC7E5A15072E1D" modified="2019-02-13" version="1">VRCSGRRGRKRKAEAEEQQTPAGKKKERAEEEGKRVVIEHWHNAEEVKSALLAACPALPVILNPEKPRKKSFEITLMDGDKEKCLWTGIKKGPPARLKFPQPDVVVAALQEALKVERMPKFVKAVAQKTSATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2H2</accession>
    <name>A0A3P9B2H2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor A, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer; binds DNA as a monomer. Homodimer. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT. In this complex TFAM recruits POLRMT to the promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Upon metabolic stress, forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT. Interacts with TFB1M and TFB2M. Interacts with CLPX; this enhances DNA-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004571515.1">
        <property type="nucleotide sequence ID" value="XM_004571458.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2H2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004110"/>
    <dbReference type="Ensembl" id="ENSMZET00005004282.1">
        <property type="protein sequence ID" value="ENSMZEP00005004110.1"/>
        <property type="gene ID" value="ENSMZEG00005003181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484483"/>
    <dbReference type="KEGG" id="mze:101484483"/>
    <dbReference type="CTD" id="7019"/>
    <dbReference type="GeneTree" id="ENSGT00440000039001"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22012">
        <property type="entry name" value="HMG-box_ABF2_IXR1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21987">
        <property type="entry name" value="HMG-box_TFAM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000043">
        <property type="entry name" value="Transcription factor A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF36">
        <property type="entry name" value="TRANSCRIPTION FACTOR A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018270974" description="Transcription factor A, mitochondrial" evidence="16">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="17">
        <location>
            <begin position="52"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="17">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="14">
        <location>
            <begin position="52"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="14">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="292" mass="33507" checksum="B60B2E3FB5EB8364" modified="2019-02-13" version="1">MAPYLLTAGVSLLAKSFSVLSCTGSLARCTSVLPSAFFSPVKFLTSEARSPPKRPLNGYMRYVQQQKPLMARQNPEIKAVDLIKTIAQQWRSLSPEQKQPFQEASLRAREQFKVDLERYQAQLTPAQLQQQAQEKRQRRAKRKAIRKKRELTNLGKPKRPRSPFNIFMSEHFEEAKGITSQAKMKSLLEDWRNLFSHQKQVYTQLAEDDKIRYKNEMKSWEDHMVEIGREDLIRERTLSTKKKPAARAKKATKKVTKKAKTVKKATGTSKPSKKTTKSRSAKTVSPPSTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B4Z2</accession>
    <name>A0A3P9B4Z2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Extracellular calcium-sensing receptor-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B4Z2"/>
    <dbReference type="Ensembl" id="ENSMZET00005005173.1">
        <property type="protein sequence ID" value="ENSMZEP00005004955.1"/>
        <property type="gene ID" value="ENSMZEG00005003742.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162782"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15283">
        <property type="entry name" value="7tmC_V2R_pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000067">
        <property type="entry name" value="Olfactory receptor C family, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000002">
        <property type="entry name" value="Vomeronasal 2 receptor, h1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000068">
        <property type="entry name" value="GPCR_3_Ca_sens_rcpt-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004073">
        <property type="entry name" value="GPCR_3_vmron_rcpt_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061:SF418">
        <property type="entry name" value="C-FAMILY ODORANT RECEPTOR OLFCQ19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24061">
        <property type="entry name" value="CALCIUM-SENSING RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01535">
        <property type="entry name" value="VOMERONASL2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017933640" evidence="13">
        <location>
            <begin position="20"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="591"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="929" mass="102424" checksum="5A482DB19F14A928" modified="2019-02-13" version="1">MSSFLQSNLLLFIVQYSYFSYTIPSSLFPSSCQLQEQFHINRMQKSGDVILGGLFPVHFFSSISDLLFTSQPEQPTCHSFNVQGFRLAQTMAFAVDEINNNSSLLPNVTLGYTLYDNCAELGIGFRGALSLVSGQEEQIILHNTCVGNPPVVGIVGDSSSTRSIAISSVLGLYRVPMVSYFATCSCLSDRQKYPSFFRTIPSDAFQVQAMIQILKHFGWTWAGLLITDDDYGFHAARSLQSEGAVLKEFVSLNWLIHVLCLYLSGVQKNNDIELILKRQNVTGLQWLASEGWTATAAVLQTPELMPYLGGTLGIAIRRGEIPGLREFLLQIRPDLLDSNSYGKTMVNEFWEFTFQCRFAPAPAGWVEGGGAICTGQEDLENVNTEFLDISNLRPEYNVYKAVYALAYSLDDMLQCKPGRGPFSGHSCATLQSLELWELVYYLERVNFTTPFGDQVSFDENGDVVPIYDVMNWLWLPDGSTTVQNVGEVKGSAFKGEEILLDEDKIFWNFNSKKPVQSVCSESCPPGTHMVRKKGEPKCCFDCIPCSDGKVSNISSKYSLGCTSCPEDFWSNPQRDHCVPKKTEFLSYHEPLGICLTATSLLGACTCAVVLGIFIYHHKTPIVRANNSELSFQVLLSLKLCFLCSLLFIGRPRLWTCQLRHAAFGISFVLCVSCILVKTMVVLAVFKASKPGGGTSLKWFGAMQQRGTVLCLASIQAAICTAWLVSASPSPHKNTQYHNDMIVYECAVGSPFGFAVLLGYIGMLAVLSFLIAFLVRNLPDSFNEAKLITFSMLIFCAVWVAFVPVYISSPGNYADAVEAFAILASSFGLLITLFGPKCYIILLKPELNTKKAIMGRAPFPWRVAEYGGAYRGQRGSWPQGGVTCPSLPSLPMSSCLPLSAPPQSPTHAGPWGKGVYSVSFCLSPRWLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B548</accession>
    <name>A0A3P9B548_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil-helix-coiled-coil-helix domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CHCHD7 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B548"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004907"/>
    <dbReference type="Ensembl" id="ENSMZET00005005121.1">
        <property type="protein sequence ID" value="ENSMZEP00005004907.1"/>
        <property type="gene ID" value="ENSMZEG00005003804.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001029"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="88" mass="10503" checksum="750B34FE63DB371D" modified="2019-02-13" version="1">MIQMDQNARKIRNQDINPCIEESDDSQKCLNAYNYDKSMCSTYFQRYKNCRKYWHNIMVQRRRDGVKPDMPTAAERLEMLTSLGGKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B582</accession>
    <name>A0A3P9B582_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B582"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005056"/>
    <dbReference type="Ensembl" id="ENSMZET00005005280.1">
        <property type="protein sequence ID" value="ENSMZEP00005005056.1"/>
        <property type="gene ID" value="ENSMZEG00005003918.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163885"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="111" mass="11966" checksum="DB2058F0C5B35624" modified="2019-02-13" version="1">GATCTGYVDVSPNEDALKEAVATIGPISIAVDASHESFQFYQSGVYDEPSCITSRYSHAMLAVGYGTENGHDYWLVKNSFGLGWGEKGYIKMSRNKSNQCGIASKASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6E6</accession>
    <name>A0A3P9B6E6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Docking protein 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DOK family. Type A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004554365.2">
        <property type="nucleotide sequence ID" value="XM_004554308.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6E6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005362"/>
    <dbReference type="Ensembl" id="ENSMZET00005005591.1">
        <property type="protein sequence ID" value="ENSMZEP00005005362.1"/>
        <property type="gene ID" value="ENSMZEG00005004165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475357"/>
    <dbReference type="KEGG" id="mze:101475357"/>
    <dbReference type="CTD" id="406361"/>
    <dbReference type="GeneTree" id="ENSGT00940000155980"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14676">
        <property type="entry name" value="PH_DOK1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01203">
        <property type="entry name" value="PTB_DOK1_DOK2_DOK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050996">
        <property type="entry name" value="Docking_Protein_DOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037751">
        <property type="entry name" value="Dok1/2/3_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258:SF46">
        <property type="entry name" value="DOCKING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21258">
        <property type="entry name" value="DOCKING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00310">
        <property type="entry name" value="PTBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="IRS-type PTB" evidence="5">
        <location>
            <begin position="159"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="469"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="669" mass="71333" checksum="C9AA0FCEE8785F0D" modified="2019-02-13" version="1">MDTHVKEGQLYVQHQKFGKKWKKNWFVLYPASQNGIARLEFFDAPGGGGGGGGGSVGGSNEKTRKLDKKIIRLSECISILPALTESCPKDNMAAFCVETNDKMHVFSAEKAVAKDWMDTMCDIAFQGGSGSSTSGAVDSNGGPQDLQMAENLIYYSREEVNEFWVTIQRTEASERCGLAGNYWLKAESDVLILKEPKTKRQVLVWPYKLLRRYGRDRVMFSFEAGRRCDSGPGTFTFETKQGNEIFILVDQAIQSQKALAEERRLSSPLNSESDCSASLQHLRNTISASMATGSGDSSSCSSREADGDSGGSKPGSADGVLGKRDGGDGGRVQGGGTGLKGRSLPEPPGMLGGAGTPPRSPKGHVGKGVSLSDESAGLYSEPADSVRLPLQIADCLYSDPVDSIKAQNQTSSPSTATAPVPTPRQRPVGDDSVGAGVQGDHPSGSNHRKHPDLYSHVYDQITMDLNALSLNGGVGKGRGGGRAVNNSRRPPGGNAEGAPSPPASSQEHIYDEPEGRAKGSIPASLGMLFYDKAHAEPHSQRRQEETVTPSGQEGKQPQRQSPPQFGQGRGTPQPPTPRFPKPLTAPKPGRGGFTRKEPVPLPPGKHGGPANNVNNNNNIWGGGDSGDRGKVVYSKVSKSKAPATAMWYSQHQQARLRAPDIIYDNLGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B7Z2</accession>
    <name>A0A3P9B7Z2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Neuroplastin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Stromal cell-derived receptor 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with ATP2B1; this interaction stabilizes ATP2B1 and increases ATPase activity; this interaction controls T cell calcium homeostasis following T cell activation. Interacts with XKR8; promoting its localization at the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B7Z2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006023"/>
    <dbReference type="Ensembl" id="ENSMZET00005006290.1">
        <property type="protein sequence ID" value="ENSMZEP00005006023.1"/>
        <property type="gene ID" value="ENSMZEG00005004625.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156195"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048545">
        <property type="term" value="P:response to steroid hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000385">
        <property type="entry name" value="Neuroplastin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000291">
        <property type="entry name" value="Neuroplastin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000387">
        <property type="entry name" value="Neuroplastin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF108">
        <property type="entry name" value="NEUROPLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01856">
        <property type="entry name" value="BASIGIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="123"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="212"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="363" mass="40976" checksum="CA12BBA9E04333F0" modified="2019-02-13" version="1">AFQSPAGFVKSPLSETKLTGDTFELYCDVVGNPTPEIQWWYSEINRADSFRQLWDGARKRRVSISTAYGINAVSVLGVSHLTLDDSGTYECRASNDPRRNDLHQNPATTWIRAQATITVLQKPSIAASEHVTLPVEGESLTLQCNLTSPHSTVQESFWMKNGEEIPETRDSSKNTEYRLKRPRADDAGVYMCVYNFSTTPSANATIEVKSAPEIVGHKRSENKNEGDHAILHCKSVGYPHPVWSWRRNDKDFENSTRIYIVSKDNYTELHILNLDIDEDPGVYVCNATNMIGHTTEKSVLRVRSHLAPLWPLLGVLAEIIILVVIIVVYEKRKKPEDLQDGESPKTNSTNNHKDKNLRQRNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B816</accession>
    <name>A0A3P9B816_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Activated leukocyte cell adhesion molecule b</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
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                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
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                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
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                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
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                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <topology evidence="1">Single-pass type I membrane protein</topology>
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<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A3P9BA51_9CICH</name>
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            <fullName evidence="12">Potassium channel, subfamily K, member 18</fullName>
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        <name type="common">zebra mbuna</name>
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            <taxon>Neopterygii</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
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                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
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                <person name="Williams L."/>
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                <person name="Kocher T.D."/>
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                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="9">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 18"/>
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        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="301"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="397" mass="45560" checksum="5E372FEEBEF5E4B4" modified="2019-02-13" version="1">MSVKAKRTISVKNESKKCAARFWRFVPHLLLCSSLVAYAALGALIFQHIEGNTPSAVQEEYHKFLCQMVETVQSLTGERSQNSVLEGVTEKMQNEFQPIWFQRPDRWDFFGSMFFCCTVFTTVGYGEIYPVTLPGKVACVFYAMVGIPLMLLVILDVGDFLAMVMSRAYIHAHTLSKNLFSRTWSPWKTEERDSSRQVLEDGTFVFSRDVVIREPLDIRQVLRSQADVRHKSIQLQNNKEIFEKILARENLLREGPLLRTLSCPELDRLQTPPRGYALWDFAGLGDEMETLNVPFVLILFIVFAYICFGGLILPIWEDDFKDFDPYYFCFITLTTIGFGDIIPKHPKFFMLTSLFIIVGMAIMSMAFKLSQTRIVSCYRQCLVCMSVGKMLTNSKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BA87</accession>
    <name>A0A3P9BA87_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neuroligin 2a</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BA87"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006787"/>
    <dbReference type="Ensembl" id="ENSMZET00005007087.1">
        <property type="protein sequence ID" value="ENSMZEP00005006787.1"/>
        <property type="gene ID" value="ENSMZEG00005005210.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160598"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000001">
        <property type="entry name" value="Neuroligin 3 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000460">
        <property type="entry name" value="Nlgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01090">
        <property type="entry name" value="NEUROLIGIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="15">
        <location>
            <begin position="43"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="621"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="802" mass="90440" checksum="D3C0FDFA7B6E826A" modified="2019-02-13" version="1">MKVFEWPDLSNSCDPDLLKPAHVLGLILLFSLASSQKMDPSKHPIVTTNYGKLRGIKKDLNNEILGPVEQYLGVPYATAPIGDRRFQPPEAPGSWQEIRNATLFAPVCPQNVHGVLPEIMLPVWFTDNLDVAAGYIQNQSEDCLYLNVYVPTEDGPLTKKHDESSMNKPRDEDIRDRRKKPVMLFIHGGSYMEGTGNMFDASVLAAYGNVIVVTMNYRLGVLGFLSTGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFHRAIAQSGTAISSWSVNYQPLKYTKILARKVGCTYAETADLVDCLRRKNFRELVDQDIQPARYHIAFGPVVDGDVVPDDPEILMQQVRFLNYDILIGVNQGEGLKFVDDSEDNDGISAAAFDYTISNFVDNLYGYPEGKDILRETIKFMYTDWADRDNGDMRRKTLLALFTDHQWVAPAVATAKLHAEFQSPVYFYTFYHHCQTETRPEWADAAHGDEIPYVFGVPMIGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNLPVPQDTKFIHTKPNRFEEVIWTKFNSKDKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHSLHDVLFPTTTRSPAGRDPGTTRPRNNVPRTTRHPYPTFPSDPEPEGSERPPQDLFPGDTRDYSTELSVTVAVGASLLFLNILAFAALYYKRDKRHEMRRHRLSPQRGGPANDLAHSQEEEIMSLQMKHSEHDAHHDMEPLRPHDILRPACPPDYTLALTITSMQPLHAFNTFPSTGHNNTLPHPHSTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BB29</accession>
    <name>A0A3P9BB29_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TOX high mobility group box family member 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004547708.1">
        <property type="nucleotide sequence ID" value="XM_004547651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BB29"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007104"/>
    <dbReference type="Ensembl" id="ENSMZET00005007412.1">
        <property type="protein sequence ID" value="ENSMZEP00005007104.1"/>
        <property type="gene ID" value="ENSMZEG00005005462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487730"/>
    <dbReference type="KEGG" id="mze:101487730"/>
    <dbReference type="CTD" id="84969"/>
    <dbReference type="GeneTree" id="ENSGT00940000158764"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21995">
        <property type="entry name" value="HMG-box_TOX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000005">
        <property type="entry name" value="TOX high mobility group box family member 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051365">
        <property type="entry name" value="TOX_HMG-box_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781">
        <property type="entry name" value="AGAP000281-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781:SF5">
        <property type="entry name" value="TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="297"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="297"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="234"/>
            <end position="256"/>
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            <begin position="263"/>
            <end position="275"/>
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    </feature>
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            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="571" mass="61768" checksum="508FD2C7DE5E86F7" modified="2019-02-13" version="1">MDVRFYPAPPSSVGSCTLPTDSGLDYYHSNKSRYGAPDRGVRLYSSLPMRPNPDGKRLPSTGFDGDNMYMNENNHEFLAPNQSYTGQTGGSGGGGGGGGTSSGNGAGDEDYEIPPITPPNHPEPPLLHLMEHESTGYLGHSLSHNGLINPYSYPELPTLMMSNMLGQDSHLVSSQMPSMQEMALHHHQQQHHHQHPDGAHYDPARNHTLINNSPPILPNPMSALSQLNPQVSRSAVPHGSPSPPGSKSATPSPSSSNQEEETDPHLKITGEKRPSSEMMKPKPKPQKKKKKKDPNEPTKPVSAYALFFRDTQAAIKGQNPNATFGDVSKIVASMWDGLGEEQKQSYKRKTEAAKKEYLKALAAYRASLVSKTYNDPVETKSAQTSQASPHMMPGNPPLYSVPPPPQPTSPYLGPGAFPLTDLQSYAGHAPRHTLSQTLSQSQMLPSISASPPSSFQISPPLHPHQQLSLHQSSLLNQPIRMQQVQSQSIISHQMGLQASLHSPPPGQQGFSHLQSEYQKSIGGSQSPGAPGPGPGPGVAQTHDWDNEYCNRECGNHCSGNMIGRDKPLYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCH9</accession>
    <name>A0A3P9BCH9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">During assembly of the complex, component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs) which contains NOLA2/NHP2, NOLA3/NOP10, NAF1 and DKC1/NOLA4. Interacts directly with DKC1/NOLA4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024658699.1">
        <property type="nucleotide sequence ID" value="XM_024802931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCH9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007619"/>
    <dbReference type="Ensembl" id="ENSMZET00005007936.1">
        <property type="protein sequence ID" value="ENSMZEP00005007619.1"/>
        <property type="gene ID" value="ENSMZEG00005005830.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101464896"/>
    <dbReference type="CTD" id="92345"/>
    <dbReference type="GeneTree" id="ENSGT00390000004697"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043489">
        <property type="term" value="P:RNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="244"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="397" mass="44127" checksum="368AE8330704AB79" modified="2019-02-13" version="1">MLQMDENLTEGNGPAEAVKDEDMEVTVTSQLEDVLVTSDNAEMVSNTQTLLEEERADAQRHSIAATVSLDTHKSSEDSEDSDSDSSSSSSSSFSSPSAPAAVEEVDEGFSQPAPIKTRDEILLEELPAVEEVCITLPEEAELQPLGTVSNIIQQLVIIQSLKDTPPLNDGSIIFKSDREAAAKVFEVFGPVSSPMYVLRFNSVDQIISKGLKEGTTLYYAPAIKEYTGYILTQQLRLLQGSDASWKNDQEPPEEALDYSDDEKEQEAKRKLKNAKKKDTSHTDNRTQNPSQRQHKHDGRGFPPRHTRPSFHHQHSFRQTEPPRHTNFPPMFIPTPCPYPPPPHHFPPSNFPLYPPPPPPPPTFFNPAFSTPFWLPNSAPFSDFPRPPPPPPPPPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BDE7</accession>
    <name>A0A3P9BDE7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intraflagellar transport 27</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574738.2">
        <property type="nucleotide sequence ID" value="XM_004574681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BDE7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007944"/>
    <dbReference type="Ensembl" id="ENSMZET00005008264.1">
        <property type="protein sequence ID" value="ENSMZEP00005007944.1"/>
        <property type="gene ID" value="ENSMZEG00005006059.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00870000136549"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001684">
        <property type="entry name" value="Intraflagellar transport 27 homolog (Chlamydomonas)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="188" mass="20915" checksum="CDEC415DA4AA5AB7" modified="2019-02-13" version="1">MVKLRARCLLVGDAAVGKSALSHMFYSDGTLFQKNYSMTTGVELLMKCINIPATNDSVELYIIDSAGKETVVDSCEKMWGEPSLLCLVFDLTSEQSFANCSRWLERVRAHCQGLHVPGVLVGNKSDLSARREVQASVAKEWAQSQGLEYHETSAKEMENCDAPLLCLARAFHSLYQEHRETIQNLNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BE84</accession>
    <name>A0A3P9BE84_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LHFPL tetraspan subfamily member 2a</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LHFP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024658879.1">
        <property type="nucleotide sequence ID" value="XM_024803111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BE84"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008192"/>
    <dbReference type="Ensembl" id="ENSMZET00005008517.1">
        <property type="protein sequence ID" value="ENSMZEP00005008192.1"/>
        <property type="gene ID" value="ENSMZEG00005006236.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005008525.1">
        <property type="protein sequence ID" value="ENSMZEP00005008198.1"/>
        <property type="gene ID" value="ENSMZEG00005006236.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477233"/>
    <dbReference type="KEGG" id="mze:101477233"/>
    <dbReference type="CTD" id="402962"/>
    <dbReference type="GeneTree" id="ENSGT00990000203589"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000020">
        <property type="entry name" value="lipoma HMGIC fusion partner-like 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF19">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0278">Fertilization</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="224" mass="23987" checksum="689E9A6EB410163A" modified="2019-02-13" version="1">MCHVIVTCRSMLWTLLSIVAAFGELIAFMSTDWLVGFPRASDAVFGPHGATTAGEAYRPTLGIYGRCIKLPQLRGILCGPYAVHFGEIASGFWQATSIFLAAGILLLCAVAFISVFTMCFQSIMKKSIFNVCGLLQGIAGLFLILGLMLYPAGWGSDKVQLYCGPDAAPYRAGLCSMGWAFYTAMGGTVLTFVCAVFSAQAEIATSSDKVQEEIEEGKSLICLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEK3</accession>
    <name>A0A3P9BEK3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MCF.2 cell line derived transforming sequence</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MCF2 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEK3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008201"/>
    <dbReference type="Ensembl" id="ENSMZET00005008528.1">
        <property type="protein sequence ID" value="ENSMZEP00005008201.1"/>
        <property type="gene ID" value="ENSMZEG00005006238.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156974"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11857">
        <property type="entry name" value="SH3_DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000078">
        <property type="entry name" value="Guanine nucleotide exchange factor DBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035532">
        <property type="entry name" value="DBS_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056466">
        <property type="entry name" value="Spectrin_DBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF146">
        <property type="entry name" value="PROTO-ONCOGENE DBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23289">
        <property type="entry name" value="Spectrin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="12">
        <location>
            <begin position="43"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="614"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="812"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1028"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="945"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="954"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1113" mass="126718" checksum="3A08AC809FE4413E" modified="2019-02-13" version="1">MGPASLQEDRELRKESKEEMESYRCLLQAGSQLESTLQQVTVPVSMKEVGGYIEKQVAYLSGGRGEDSSVIITLPECSAFSDIPEEALTKVFTYLTLIPRTRQPGVKFIIILDRRLDTWASIKTALARIAASFPGNLHLVLVLRPTSFFHRTVTDIGFRFSQEDFMLKMPVVMLSSVTDLLRYIDENQLTSEFGGTLDYCHSDWIVLRTAIESFAVTVKDIAQMLQGFGTELAETELPEEAKAIEYLLELHTDKYRKLKDAIRSVSKEGRHLLSSLETTAKEDDSQWDVKLDWETVQRLLAQLRDMESAFDGFFEKHHLKLHQYLQLLRYEQSFQEMELCLEHLTAQERELCISANSLAETEQALKRLNNLESNAQEVTARAQIIILHGHQLSAGHHYAMALIMQRCNELRHYCDTLTAALKSKHTRLLQTHQMLLCLGQAQTWCDDAAYLLANQLVDKFQSKEGAQAALRDIEKLLEGAPSMLSSGLDIVTAEYEAVITPHFQAQIGKMFEKHAAVQQMIQNRQACLRKLADKHVRPVQLVAPRPENTPRSKSPLFSPKHGDGLKFTFDLSLPGKRASRKVPNSRKIEVMHDYQESRSCVSYSLDGDDSPDLLKRHVMRELIETERIYVEELLSVLLGYRAEMDNPALSGVLPPILRSKRDILFGNMPEIYNFHSRVFLQDLEGCLEAPEAVGACFLERKESFQMYESYCQNKLRSEALWRQFSDCGFFLECQKKLEHKLGLDSYLLKPIQRLTKYQLLLKELIKYSTDCEGTSELQGALAAMLDLLKSVNDSMHQIAITGYEGDICELGRVLMQGSFSVWISHKKGPTRMKEMARFKPMQRHLFLYERALLLCKRREEHGDGCDKTPSYSFKHCLKMTAVGITENVKGDVKKFEIWYSGREEVYVVQAPTVEVKMAWLNELRRILTNQQKMLRDEAYQHGHIVDHMPLSPPLSESKQQRASVSSEETESGRSSPDPQPHSPKHQHNRRSWPGAPHSVDICEGLEEWPGGRDPFHPSDTEEEVLVQLSPGRYRVLADCLQNGPDSIIIKRGDVIQLQCEDNRGRWLVKNVTLQQEGFLPAATLQLIIGGSRHENSSRLGDPGNLKVRKLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BF89</accession>
    <name>A0A3P9BF89_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cas scaffold protein family member 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAS family.</text>
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        <property type="nucleotide sequence ID" value="XM_004559850.3"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005008579"/>
    <dbReference type="Ensembl" id="ENSMZET00005008919.1">
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        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
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        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
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        <location>
            <begin position="1"/>
            <end position="62"/>
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            <begin position="580"/>
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            <begin position="129"/>
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        </location>
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    </feature>
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            <end position="646"/>
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    <sequence length="780" mass="87064" checksum="FA1D108BF38632E0" modified="2019-02-13" version="1">MNQLAKALYDNTAECPDELAFRKGDILTVINPNVAGTSGWWMCSLYGRHGLAPANRLKLLPQMVTPAVHEVPRSTHGKTDDSVQNIYQTPRTTSSPAYERMDMIYKVPSAHLLASKGPEAPGPEAHKPSSFSTASSPNGKMYDVPNQPKKASFYTKTTPPTPMPRMQVLEKGLNSPETLMCSKPEDSYVYPVPPPPSQEPNYDIPIPSATESRNKTIGGYNTLPSSRKPELIYDVPVGPEKQSPSRGISDTLSSKSISRPMYDTLPAHRKESPPILLYDIPKPKSPDIQIKTKVLPKDYNKLPTPKPTEESVYVVPAKEEHLIQGVTEQPNDQNPIECRGNSSNDFELQRVRLQRMRNFLVCTTFHGIQESGQTALREDEQGRNKHLSAADNQRISTASSSSNSSCDSLALSSSSPELLREVTLGQDEACRKLLDLQESVCEAVPKLMHFVSSHWRCKEHLEKHLKEIKEAAELIVCSLTGFLNFALDVKGNARRLTDANLQTRLFKQLSIIEDSGVILQQTVSNLNEAKWPLNKLSQEPGKVQTPDQLERFVMVARTIPDDVKRLVSIINANGKLLFRTPQRDQESVNTTDPPEKKCPDKTKQEGDLAEDDNVYVELQTKKEENKQQEVQKEPKENVTPRTETTKAKQHSSDSGTEEKQLSSMSEHCRLYFGALQKAIGGFVGSLQDGQPPEKFISQSKLVIMVGQRLVDTLYREAHRKGSNQSLLCKSNHLCALLKQLAVATKKAALHFPDKQALREAQEFATQLAQRAQHFRLSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFJ2</accession>
    <name>A0A3P9BFJ2_9CICH</name>
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        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004539070.5"/>
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        <property type="protein sequence ID" value="ENSMZEP00005008663.1"/>
        <property type="gene ID" value="ENSMZEG00005006596.1"/>
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        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="beta3GnTL1_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22916:SF3">
        <property type="entry name" value="UDP-GLCNAC:BETAGAL BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="46"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="386" mass="44501" checksum="1DB07F47724F99E6" modified="2019-02-13" version="1">MRRSEDTEQQVWESEVDMNPPKRLRTTETLTGGKEREVEKSTVDVSIVMPVYNASCWLDECLQAILVQDFSGSMELSVFDDASTDDSKKVVEGWRERLEAKGISVVISGHNSEQPKGVGYAKNKAICQSRGQYLCFQDADDIMLPQRVRLQYEASVLHKNTLIGCRVQRVPEGSTERYTRWINTLSQDQLITQVYTSHGPSVVMPTWFCSREWYQKVGPFDEGGKGVPEDLLFFYQSLRHGGGLFRVDQCLLIYRYHEKAATHSVTEETIWKLRVDFLQERVLSQWESFTIWNAGKQGRKLYRSLSPANQKKVKAFCDVDEKKIQKGFYTYEESKERPKPKIQVLHYKNASAPFIICVKLDMTGGNLEENLNSLQLKEGIDYYHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGM5</accession>
    <name>A0A3P9BGM5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FXYD domain-containing ion transport regulator</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FXYD family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGM5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009038"/>
    <dbReference type="Ensembl" id="ENSMZET00005009387.1">
        <property type="protein sequence ID" value="ENSMZEP00005009038.1"/>
        <property type="gene ID" value="ENSMZEG00005006847.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287037"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043269">
        <property type="term" value="P:regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.780">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047297">
        <property type="entry name" value="FXYD_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000272">
        <property type="entry name" value="Ion-transport_regulator_FXYD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14132:SF14">
        <property type="entry name" value="FXYD DOMAIN-CONTAINING ION TRANSPORT REGULATOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14132">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02038">
        <property type="entry name" value="ATP1G1_PLM_MAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01310">
        <property type="entry name" value="FXYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017845644" description="FXYD domain-containing ion transport regulator" evidence="8">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="69" mass="7555" checksum="86B2FD2A56DDD551" modified="2019-02-13" version="1">MGHLTLVAFLTVLFGLFVEAEANSFVYNYESLRIGGLVFAILLISAGIGFLLYGKCKKRGKHTDNSSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGV7</accession>
    <name>A0A3P9BGV7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoadipate dehydrogenase complex component E1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-oxoadipate dehydrogenase, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Alpha-ketoadipate dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Dehydrogenase E1 and transketolase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">2-oxoadipate dehydrogenase (E1a) component of the 2-oxoadipate dehydrogenase complex (OADHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoadipate (alpha-ketoadipate) to glutaryl-CoA and CO(2) catalyzed by the whole OADHC. Catalyzes the irreversible decarboxylation of 2-oxoadipate via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Can catalyze the decarboxylation of 2-oxoglutarate in vitro, but at a much lower rate than 2-oxoadipate. Responsible for the last step of L-lysine, L-hydroxylysine and L-tryptophan catabolism with the common product being 2-oxoadipate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoadipate + H(+) = N(6)-[(R)-S(8)-glutaryldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:69576"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:184385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:69577"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014265781.1">
        <property type="nucleotide sequence ID" value="XM_014410295.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGV7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009122"/>
    <dbReference type="Ensembl" id="ENSMZET00005009471.1">
        <property type="protein sequence ID" value="ENSMZEP00005009122.1"/>
        <property type="gene ID" value="ENSMZEG00005006901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480158"/>
    <dbReference type="KEGG" id="mze:101480158"/>
    <dbReference type="CTD" id="55526"/>
    <dbReference type="GeneTree" id="ENSGT00950000183125"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000005">
        <property type="entry name" value="probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000005">
        <property type="entry name" value="Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000034">
        <property type="entry name" value="Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
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        <property type="entry name" value="KGD_C_sf"/>
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        <property type="entry name" value="ODO-1/KGD_C"/>
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    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
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    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
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    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="18">
        <location>
            <begin position="574"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
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            <dbReference type="ARBA" id="ARBA00006936"/>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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            <dbReference type="ARBA" id="ARBA00023052"/>
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            <dbReference type="ARBA" id="ARBA00023128"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00040865"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="ARBA" id="ARBA00042537"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00045379"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00051440"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM00861"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="923" mass="103291" checksum="3C3481809D1E3AAA" modified="2019-02-13" version="1">MSALILLKSSLSRLPQSVARQVVGCSYHTERGVYGYRPKSTERDQKWQSERVAALNQDHALARLVEAYRAHGHKAAKINPLLPQKPVVDSVPEISMLTGTMSGQLNTSGLRHFGKAQASVEEVQAYLEEAYCGHLSVEPDQLSSLDEREWFADRFEELKRENFSPEERRQLAKIMLESQEFDHFLATKFATVKRYGGEGAESMMGFFFELFHRSAHSGVTDIVIGMPHRGRLNLLTGLLKFPPELMFRKMRGLSEFPDTSPAIGDVLSHLTSSVELDFRAKHPLHVTMLPNPSHLEAINPVAQGKTRARQQLRKEGDYSPEDDAQPGDQVICLQIHGDGSFTGQGIVPETLTLSNLPHYRVGGSIHLIVNNQVGYTTPSERGRSSLYCSDVGKMVNSAVIHVNGDDAEEVLRAARLAVDYQRHFRKDVILDLICYRQWGHNELDEPFFTNPAMYKIIRSRKSIPDAYSDQLISEGLMTEVERDEIKTKYYSMLNDKLSNMTLYSPPPTNLQGRWGDLVEPQARVTTWDTGVPIPLLQFVGVKSVDIPEQIQLHSHLGKTHVQARLQKLEEGTKLDWSTAEALAFGSLLCQGFNIRISGQDVGRGTFSQRHAMVVCQDTNDMYIPLNHISPEQTGFLEVCNSPLSEEAVLGFEYGMSIAQPKLLPIWEAQFGDFFNGAQIVFDTFISGGEAKWLLQCGMVILLPHGYDGAGPEHSSCRMERFFQMCDSKEEGVDGDTVNMSVVNPTTSAQYFHLLRRQMVRNFRKPLVVVGPKTLLRFSGAVSSLTEMAPGTSFRPVLGDTSVSAESVQKVVLCSGKHYYALLKQRETSAANQNTALIRVEELCPFPLDALQQELKKYPKAKEFIWSQEEPQNMGPWSFVAPRFEKQLACKLRLVSRPALPAPAVGIGTLHHQQQEAILTATFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHI8</accession>
    <name>A0A3P9BHI8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger CCCH-type containing 12A</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551034.1">
        <property type="nucleotide sequence ID" value="XM_004550977.2"/>
    </dbReference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005009216"/>
    <dbReference type="Ensembl" id="ENSMZET00005009566.1">
        <property type="protein sequence ID" value="ENSMZEP00005009216.1"/>
        <property type="gene ID" value="ENSMZEG00005006997.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477172"/>
    <dbReference type="KEGG" id="mze:101477172"/>
    <dbReference type="CTD" id="798235"/>
    <dbReference type="GeneTree" id="ENSGT00940000155107"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061158">
        <property type="term" value="P:3'-UTR-mediated mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18729">
        <property type="entry name" value="PIN_Zc3h12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040546">
        <property type="entry name" value="Rege-1_UBA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040757">
        <property type="entry name" value="Regnase_1/ZC3H12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF10">
        <property type="entry name" value="ENDORIBONUCLEASE ZC3H12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18561">
        <property type="entry name" value="Regnase_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18039">
        <property type="entry name" value="UBA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="12">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="632" mass="72097" checksum="7E9B843F376971B1" modified="2019-02-13" version="1">MDEALPSLSSVSDSLEADSEEFQLRVDFFRKLGYTPSEVMAALRKQGLSTDTNAVLGELVRNRTSSVPCISSSDSDERSTRQNDSLQPPSWGLGSCKNTTQLWDQNKPDEELRPVVIDGSNVAMSHGNKEVFSCQGIQLAVNFFLDRGHTSITVFVPSWRKELPRADAPLTDQHILLELEKRKIVVFTPSRRVGGKRVVCYDDRFIIKLAYESDGIIVSNDTYRDLQAERPEWKKCIEERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPRPTEQMRQLCPYEKKCTYGIKCKFYHPERVNQPYLSLADELREKAQISTVKEERNASLSPRQLQSDPALAQNAYFHPRDSNKELKRDQQTSSPPYHVSENKLLYWEDPRHNPNHMPCSVTGTQCQKEWPGLHLMPNHYYANMSQEYLDSGLGSFESQYSDISHSLHNSKMLRLQYQSAPPGATNSPVHLEKNNINQPCKCCSHAMPSTVHQQFHGNMDSQAQPQYSAYHPNALTPTASHQRSLPSHFQYSGGTHVQQHYWSDPFQGLPQASRPNSLPSSTRSSHYHNSCCSSNSHQYYSRGQQPSSAAFDSQRLELRNKLKTIFNPHLVDTVMEMFPNLMNAEKLAAEILKLKAQRDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BL26</accession>
    <name>A0A3P9BL26_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BL26"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010644"/>
    <dbReference type="Ensembl" id="ENSMZET00005011019.1">
        <property type="protein sequence ID" value="ENSMZEP00005010644.1"/>
        <property type="gene ID" value="ENSMZEG00005007998.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156114"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071690">
        <property type="term" value="P:cardiac muscle myosin thick filament assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060047">
        <property type="term" value="P:heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055018">
        <property type="term" value="P:regulation of cardiac muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048769">
        <property type="term" value="P:sarcomerogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030241">
        <property type="term" value="P:skeletal muscle myosin thick filament assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030240">
        <property type="term" value="P:skeletal muscle thin filament assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10526">
        <property type="entry name" value="SET_SMYD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000132">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000013">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000005">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044418">
        <property type="entry name" value="SMYD1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF184">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="2"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="11">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="526" mass="60244" checksum="2F90A909780C37CF" modified="2019-02-13" version="1">METVAIFDSPGKGRGLKATKEFWAGDVIFSEASIAAVVFDSLAERICHSCFRRQEKLQRCGQCKFAHYCDRTCQRAGWAEHKLECSAIKAYGKVPNENIRVVARIMWRLDKEGSTVSDMQLTTLDELEDHIADMPEDDLKELKVDIHNFLDYWPHNSKQHTIDDISHIFGVINCNGFSVSDQRGLQAVGVGLFPNLCLVNHDCWPNCTVILNHGNQSAVNTMFHSQRRIELRALGKIAEGEELTVAYVDFLNLSEERQRLLKTQYFFDCTCEDCKNRIKDDMKIGGREEDGVKPSEEQVKEATDYCFQMLEKMEKARLNGDYHEVVKICRECIEKTEPVLADTHIYLLRMWSTMSEVQAYLQYFDDAADYARKMVEGYMKLYHPNNAALGMAAMRAGVTHWQAGQIEVAHGMICKAYAILMVTHGPTHPITKDLDVSVTLKLFKLGLLKLFNRNKNFPGPLSADVSVLISSQAMRIQTEMELRMFKQNEYVYHSMREAALKNKPMTMMHEPKSVEEGIKNLFHRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BL47</accession>
    <name>A0A3P9BL47_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="6">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="6"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BL47"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010664"/>
    <dbReference type="Ensembl" id="ENSMZET00005011040.1">
        <property type="protein sequence ID" value="ENSMZEP00005010664.1"/>
        <property type="gene ID" value="ENSMZEG00005008023.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011219"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="10">
        <location>
            <begin position="87"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="11">
        <location>
            <begin position="171"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="222" mass="25706" checksum="D4E749C3F7C80A67" modified="2019-02-13" version="1">MRRILSTIILRHICFIGGNLPSRATRIVGLPRVFTSKYCSGTSMDLSNMRKRYKGDLECFEESQLVSLDPIKQFGNWFDEATKCPEIGESNAMCLATATKDGRPSARMVILKGYSSEGFRFFTNYESRKGCELESNPHACLVFYWEPLNRQYLRQKNAELEEKYKDTEGRYIVKPFLIEFWQGQTNRLHDRIVFTKLKDGESELGEFQHAAEGGWVYQRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BLF1</accession>
    <name>A0A3P9BLF1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Linkage group 11 C1orf232 homolog</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004551170.2">
        <property type="nucleotide sequence ID" value="XM_004551113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BLF1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010745"/>
    <dbReference type="Ensembl" id="ENSMZET00005011123.1">
        <property type="protein sequence ID" value="ENSMZEP00005010745.1"/>
        <property type="gene ID" value="ENSMZEG00005008083.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101466534"/>
    <dbReference type="GeneTree" id="ENSGT00530000067301"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031399">
        <property type="entry name" value="TDRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35663:SF3">
        <property type="entry name" value="GENE, 30191-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35663">
        <property type="entry name" value="TESTIS DEVELOPMENT-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15683">
        <property type="entry name" value="TDRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="203" mass="22067" checksum="7524B33653B9124F" modified="2019-02-13" version="1">MNPMWKVYKSKVLKTINPEYEEDTAEEVTEVENDMSPVQEEEGPNAVSQLARKMQGAGAKSWNRLSAIFNKDDEHQLLEETECPPVADHPLAAKPEEPPRPTRRTGFWDSFASNWAAKKQAEAAAAAAENEAATGEGEEGVIEAGGAESQQDGQVTEGEQSEGGGRSNNSFSKYVSLGGGNEDASFKWNFVTSKLAELKTKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQH0</accession>
    <name>A0A3P9BQH0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex, a building block of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5 tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome. Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004549386.1">
        <property type="nucleotide sequence ID" value="XM_004549329.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004549387.1">
        <property type="nucleotide sequence ID" value="XM_004549330.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004549388.1">
        <property type="nucleotide sequence ID" value="XM_004549331.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQH0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012174"/>
    <dbReference type="Ensembl" id="ENSMZET00005012602.1">
        <property type="protein sequence ID" value="ENSMZEP00005012174.1"/>
        <property type="gene ID" value="ENSMZEG00005009146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468869"/>
    <dbReference type="KEGG" id="mze:101468869"/>
    <dbReference type="CTD" id="11157"/>
    <dbReference type="GeneTree" id="ENSGT00940000154978"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000010">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="80" mass="9068" checksum="43E14896FA9874F5" modified="2019-02-13" version="1">MSLRKQTPSDFLKQIIGRPVVVKLNSGVDYRGVLACLDGYMNIAIEQTEEYVNGQLKNKYGDAFLRGNNVLYISTQKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BR91</accession>
    <name>A0A3P9BR91_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CASP8 and FADD like apoptosis regulator</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004555522.1">
        <property type="nucleotide sequence ID" value="XM_004555465.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BR91"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012448"/>
    <dbReference type="Ensembl" id="ENSMZET00005012887.1">
        <property type="protein sequence ID" value="ENSMZEP00005012448.1"/>
        <property type="gene ID" value="ENSMZEG00005009363.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464799"/>
    <dbReference type="KEGG" id="mze:101464799"/>
    <dbReference type="GeneTree" id="ENSGT00530000064199"/>
    <dbReference type="OrthoDB" id="8816507at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000016">
        <property type="entry name" value="CASP8 and FADD-like apoptosis regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF3">
        <property type="entry name" value="CASP8 AND FADD LIKE APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DED" evidence="4">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="4">
        <location>
            <begin position="94"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="244"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="455" mass="52202" checksum="5CDF067D6952F272" modified="2019-02-13" version="1">MAVPDQFQLLAINEIAEALSSNERSRLFYLCESLDTDHSVACMKEMLRSKVTQHQNAHLFLAELMWRLGRLDILRKVCKVNRDDLERTRQMVPRFRVLMTELSEELDTEDLDSIKFLLSCKLSREKLEKTKSFLDIIVELEKLDSVSPERLDFVEDCLTNIGRIDLVKKLTTYKNSAGAPEQQRNLSLQQPRRISHVTQERRIVGVSPRSGACLEPSSESQPDCYKFNTNPRGHCVIIDCVGNDGEKLEQTFKALRFSVNLHQYLSSDEVFSALENILDKMEKLRNDSFVCCIISRGTESQLLGTDSTGNGFSINEVRRLFNANRCPLLAGKPKLFFIQRYNVPKLSLRPRMNPDDGHLETDGCDGAVTAAIPMDADVFWSHCWTDECQLEEEEHSSVYVKALTNALNKAQNRKIKIDDIQMEVNNIIFEHSRSNPQASYHLDVKHTLRRDLYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BT06</accession>
    <name>A0A3P9BT06_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BT06"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013093"/>
    <dbReference type="Ensembl" id="ENSMZET00005013542.1">
        <property type="protein sequence ID" value="ENSMZEP00005013093.1"/>
        <property type="gene ID" value="ENSMZEG00005009825.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163863"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19903">
        <property type="entry name" value="DSRM_EIF2AK2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000251">
        <property type="entry name" value="eukaryotic translation initiation factor 2-alpha kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044452">
        <property type="entry name" value="EIF2AK2_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF166">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DRBM" evidence="11">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="11">
        <location>
            <begin position="211"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="358"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="649" mass="74379" checksum="BBF9A08E91019F88" modified="2019-02-13" version="1">MATKNYVAELNEYAQRNRLKLKYEYLGSDGPDHNKVFSQKAIIDGKDYPKGVGKTKKDAKLKAAENALRCLLDGKCQDLTENAAEASTPAETDINFICWLNEYGQRNRLTIKPMETTRPGPNNAIPWCSFMVGDKEYPAVSGKTAREAKEEAAKLVYDIINGNKTTDTADENHSDGSGQQSEDLSENVFDLCTTTKNLTVNSKDPSLVETNYIGLINDYCQRENCSYTFVDEKICGTPDKRQFFYKLRINNKQYPVGKGKSIKEAKQSAARQAWFVVQEQSSKVLIFLSLLCLIRYSLNPSIHRLPHILFRVAGGAGAYPSCNRARGRVHPGQLSVFDHYVTLLHKCVVAVHRFTLEFEPLDHLGKGAFGSVYKVRHKQLKIEYAVKVGCYKEKSLREVRTLSDLFHRNIVRYYTFWMQDTGYEWDLRDSYDSYASSHTADNPETKFLYIQMELCAKNTLRDWIDEKNKESEQDSKRREESLRIAQEIVCGVEYIHSKNHIHRDLKPANIMFGVEGEVKIGDFGLVTSDDDDEERTVCKGTPSYMAPEQKTERKYDRKVDMFALGLIFFELLWKLSTGYERAKVRFTAVMQRFPEEFSVTFTKEKQIINSLLSEKPEDRPDASAVKAELEEWTQIFNSHKASRQENQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BU13</accession>
    <name>A0A3P9BU13_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized LOC101486355</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BU13"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013121"/>
    <dbReference type="Ensembl" id="ENSMZET00005013570.1">
        <property type="protein sequence ID" value="ENSMZEP00005013121.1"/>
        <property type="gene ID" value="ENSMZEG00005009834.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000069547"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016064">
        <property type="term" value="P:immunoglobulin mediated immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23037:SF42">
        <property type="entry name" value="CYTOKINE RECEPTOR COMMON SUBUNIT GAMMA ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="645" mass="70933" checksum="B89114875C5AEEB3" modified="2019-02-13" version="1">MKIRELNCLVMDSNRQVCNWISYTVLLFGYITAAVLPGKNPTIGFNLECTYDFDQVMQCELELQNCTEYSMTLQVQDNEENCAVQQCGIGKCCCSFKLMRVLGEALTAKVWKDGNIMESKAINVMESIKPKTPTIKSVNELEGNFEVKWTSNMKGFLNNEMTAVVTYYKKGETEKTSGPFKPATVDGLNYYIIKGQDLDPSSAYVVSVKSFISLSGKFSDSSEEWEFQTARSPHYLLVVIIICLSIAAVILSAVMCGCYFKFKINWWDVVTKPPNPSFLNIYPNKEQVLKPEPSITSTICIEPLIPDDSKLGSKMSLTDTSSGSLQQTSGISTGSSDLSYANAEPPETMNEEPPITKAVHDVLSKLFLNISPISPVTTSPLTQLMNMQKSDLCSAPYSPCSVQANDTSSGSSVFENKTYSLLIPVSEHQAMTGDLEAQEKAEMLCVPDYHPSKSDMGICPHQLLPSCQVPAQQDSGSFLRQPNMPYQSYKADSGTFSYEEDTSLSSVSSGTNASDPCEFSSRAEAEFESSDEVISGKPKLGEEVTICDENPCYGCVPKGSNSFLAMDDDYQALPSLEKQPDILLLEQGNGEYEKLFKKTPQSILSEVFPGFIHNVQGGQLQIPFPPLMSVDHSVPIITDAGYQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BUU5</accession>
    <name>A0A3P9BUU5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="29">Solute carrier family 25 member 30</fullName>
        </submittedName>
    </protein>
    <organism evidence="29 30">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73403"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30924"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73227"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73223"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30936"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:71615"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(S)-malate(out) = (S)-malate(in)</text>
            <dbReference type="Rhea" id="RHEA:74555"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73407"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30927"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73399"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:29990"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73395"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>maleate(in) + sulfate(out) = maleate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73199"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>malonate(in) + sulfate(out) = malonate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73195"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:72275"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>phosphate(in) = phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:32823"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>sulfate(in) = sulfate(out)</text>
            <dbReference type="Rhea" id="RHEA:34983"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulfate(out) + phosphate(in) = sulfate(in) + phosphate(out)</text>
            <dbReference type="Rhea" id="RHEA:71631"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>sulfate(out) + succinate(in) = sulfate(in) + succinate(out)</text>
            <dbReference type="Rhea" id="RHEA:73411"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73207"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73215"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004567277.1">
        <property type="nucleotide sequence ID" value="XM_004567220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BUU5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013654"/>
    <dbReference type="Ensembl" id="ENSMZET00005014121.1">
        <property type="protein sequence ID" value="ENSMZEP00005013654.1"/>
        <property type="gene ID" value="ENSMZEG00005010276.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474915"/>
    <dbReference type="KEGG" id="mze:101474915"/>
    <dbReference type="GeneTree" id="ENSGT00940000158961"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000006">
        <property type="entry name" value="brain mitochondrial carrier protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 27 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 28" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="27">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="27">
        <location>
            <begin position="104"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="27">
        <location>
            <begin position="198"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00037004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="286" mass="31813" checksum="F0B8F93C6AFE98D3" modified="2019-02-13" version="1">MSNVNWKPFVFGGLASVTAECGTFPIDLAKTRLQVQGQVGDSKYREIRYRGMLHAIMRIGREEGLRALYSGIAPAMLRQASYGTIKIGTYQSFKRLLVERPEDETLLTNVLCGILSGVISSSIANPTDVLKIRMQAQGNVIQGSMMGNFINIYQEEGTRGLWKGVSLTAQRAAIVVGVELPVYDLTKKHLILSGYMGDTVYTHFLSSFVCGLAGALASNPVDVVRTRMMNQRGGALYQGTLDCLLQTWRSEGFMALYKGFFPNWLRLGPWNIIFFLTYEQLKQISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVW6</accession>
    <name>A0A3P9BVW6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rho guanine nucleotide exchange factor 28</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005014057"/>
    <dbReference type="Ensembl" id="ENSMZET00005014529.1">
        <property type="protein sequence ID" value="ENSMZEP00005014057.1"/>
        <property type="gene ID" value="ENSMZEG00005010602.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155831"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20876">
        <property type="entry name" value="C1_p190RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14680">
        <property type="entry name" value="PH_p190RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000004">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000021">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037819">
        <property type="entry name" value="ARHGEF28_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041020">
        <property type="entry name" value="PH_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051632">
        <property type="entry name" value="Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944">
        <property type="entry name" value="AGAP007712-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13944:SF22">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17838">
        <property type="entry name" value="PH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="753"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="952"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="821"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1293"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1422"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="828"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1295"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1422"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1557" mass="173851" checksum="22294D7EC0E4E8C3" modified="2019-02-13" version="1">MELSRRKVPLYGEAKVFALLDGFDSAPEDAEVYIVLEGSTLIHVTRAHSDVMLCFIVPGHNLAEMVSVQAYLCSETIPLTWVGEASLEYVHDDAQDLAEHLVIHGHCLNSTDHNELSSLFNLGQQSSHWAMDHRVALAMANLDIPPNWNVLGSHSGDEHCPRESPLHLAVRWGMCRLAELLLCQPGGLMAVNLPNENGVTPLQLAQTAGNTELLELLSNPPNPLATPPAGLSQVWADRSRLLRFCHDMGNLTLTVRQNLRWSSEESRHADILLLRERLRDEDFLRGIKALRRERVETILGKEELVDDPADSALYPDINGENSAVEENVPSFYSEVYKEPLMFCLNEEDEEDEPSQSDSEKSQSIRESQASSPTLAAAARLSAMIHGKDQVYANAMLVDQVDDADIKYRSPGEEEVSPASHADSSSWDSFSVTPPNSGNSSQSRCLSSPHNRLRGIQGSGLENHREQSPLVSPPCPFASSPSFPSSPLASALRLFEEAHKRQPQTGLPRSPSLSRRGCSFTEASRGLSPSLECDSGEEDILGHSYPSSSIRQQSTLRSSSGEERDSFDASPDFSRAQSDITHKSTKSPEEAEVRLRSYSYSSPKAKPSRPLLNRDATITDLEEDGAFNSSGRSLLQALSLSKSLSRLNQVKQRTFNLTETPREKRVLGFRKRAQSAEEESSAPLEHLTLTEFLKEIEDEDWDKYIIPSKVESEKYKVSRTFSFLKSRMSSTRSKTKVKGKEVKEGKEKSVTPNGHQFVPVSPSGPALCVACDKSVSGKELLQCSNCLLNVHKNCRESVAACAKKLQDRNALLMKNKAFSLPQNPVKENPPSSIFSSSSCPSSSLPTMNREKRETVAPLTKSLSISADSRRLSDSAGADSECAAPTCTISSLSDDGTPVTTTPPAIDLPITTQDTVDAPLLGDLSADLLGLEAESWSLAVTAEFCRQHDRHTIKRQDVIYELMQTELHHIQTLTVMSEVFRRGMLEELQLDWDCVARIFPCLDPLLVFHRNLFRALQERRQAETQTENSQNYIIHRIGDILLQQFSDENAEKMKNLYGEFCSHHIEAVNVFKELQQQNKKLQNFVRQQSNNSLVRRREVPEFILLVTQRITKYPVLLERILHYTKEGSIEHSDLSTALAQIRDVVAAVDLTVNKYEKFQELQEVLARLENKSFAKLKNGKVFRKQDLHSKHRDLQHKGLVYWKTATGRLKDTLALLLTDILVFLQEKDQRFIFAAVDQKPPVIPLQKLIVREVANEERGMFLISASSAGPEMYEVHTTSREERNAWMRHIRQAVESCPEEEEEDERSAETEEARQAAEMRIQKITKFQETLLGQDQRICNSLEEKLQLYAELTELTLQSPEPVPHRHLLVESVPYTDSETPRQASSLLTAALREAENLITILQAREGIAVQSQSSPVRGPECCSYNSHGSSIQESPSEPDYLSTLSMSSTSLGSDSELAGMDNSLWSSAVELRKGENKGTLVKVAESVQSLTQLLYSLQAAVTLQDSCYEVHQLLLQEGEGPQLRTLASLQSSLVSVTSYPLKAFSQCKTLHVLRKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BWG9</accession>
    <name>A0A3P9BWG9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the P33MONOX family.</text>
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        <property type="protein sequence ID" value="ENSMZEP00005015661.1"/>
        <property type="gene ID" value="ENSMZEG00005011754.1"/>
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    <dbReference type="GeneTree" id="ENSGT00390000000537"/>
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        <property type="component" value="LG10"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026759">
        <property type="entry name" value="P33MONOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28342">
        <property type="entry name" value="MONOOXYGENASE P33MONOX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28342:SF1">
        <property type="entry name" value="MONOOXYGENASE P33MONOX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15302">
        <property type="entry name" value="P33MONOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
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        <location>
            <begin position="67"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
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        <location>
            <begin position="73"/>
            <end position="84"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="162"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016432"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015661.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="314" mass="33645" checksum="4BA42C7BD30B17DF" modified="2019-02-13" version="1">MSGSGDLPAIEGSGMGGMKLPVGMTRRAISYDDNLEAPMSTPPHDISINNLWKRPIIPERKFTHLAEEDESDASQSAAQDTGASRPQAVVKTKASSIIMNSLINKQTQDSVYKFEQTAGLSDTGYTPHKGLTAEETRHHHRVPETIQKLQIQSMEAKEERQSSSAHSTPSNTPHSSPKSQRRGWFGSSSSELSIASSSNSSLDMAGVDVGGGGGGGVVERWGVFGPRPPVHKSTSDLGSDSTTAAGFALQAYRGAQKPTPMEVMKTQARLADSASIQKVSPPTMEIPTVEGRRHGTRTHKLKPRDMNILTPSGF</sequence>
</entry>
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        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            <authorList>
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        <scope>IDENTIFICATION</scope>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="133" mass="14186" checksum="D803062D4BA3E019" modified="2019-02-13" version="1">CCSICCTTVVLCCTICSTTVVLGCSICCTTVVLCCSICSTTVVLCCSICSTTVVLCCSICSTTVVLCCSICCTTVVLCCSICSTTVVLCCSICSTTCAIQIHLFFFFITKLLYYVVLFVLCCDVSYRVVLCYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C405</accession>
    <name>A0A3P9C405_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small integral membrane protein 8</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Pseudocrenilabrinae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <text evidence="2">Belongs to the SMIM8 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="UPF0708"/>
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        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 8"/>
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        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 8"/>
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        <property type="entry name" value="DUF4500"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014451"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="95" mass="10591" checksum="DD2F99DE45A8EFF2" modified="2019-02-13" version="1">MADKEAGAGVESHGEKGFRTPGLRSVQTTTLFRAVNPELFIKPNKPVMAFGLLSITLCVGYLGYLHAMKENDQQLYEAIDSEGERTTRRKSSKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C749</accession>
    <name>A0A3P9C749_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Si:dkey-224e22.2</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C749"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017917"/>
    <dbReference type="Ensembl" id="ENSMZET00005018498.1">
        <property type="protein sequence ID" value="ENSMZEP00005017917.1"/>
        <property type="gene ID" value="ENSMZEG00005013459.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182942"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000049">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000036">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="5">
        <location>
            <begin position="13"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="6">
        <location>
            <begin position="372"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="7">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="589" mass="66748" checksum="6E84FD67D2A9B6D7" modified="2019-02-13" version="1">MSRLEGLKANSSQFTLEGEPFRILGGSVHYFRVPRAYWEDRLLKMKACGLNTLTTYVPWNLHEPERGTFNFQDQLDLKAYVSLAAQLGLWVILRPGPYICAEWDLGGLPSWLLQDEEMQLRTTYPGFVNAVNLYFDKLISVIKPLMFEGGGPIIAVQVENEYGSFHDGFLHPSLGIKELLMTSDNWEGLRCGGVEGALKTINLQRLSFGAIQHLADIQPQKPLMVMEYWSGWFDVWGEHHHVFHAEDMLAVVSEILDRGVSINLYMFHGGTSFGFMNGAMDFGAYKSQVTSYDYDAPLSEAGDCTPKYHHLRNLFSQYHSEPLPGVPSSPERKAYSPAFIQQHLSLWDILQFSDKSDKPVNMENLPVNNNNGQSYGYTLYETTITGGGALNSRNNIRDRAVVFVNRECVGCLDYKTHEVALPDGKGERTLSFLVENCGRVNYGKALDEQRKGIVGDIVLNNTPLRGFSISCFDMKPSFIKRSVIWIKTSFLPKSYSARLCVDGPPKDTFCIYPQSWGKGIIFVNGQNLGRYWFIGPQHFLYLPAPWLRSGENEIIVFEEQRVHDKLLFAENPDYGKVIDVYKLPFCTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9P8</accession>
    <name>A0A3P9C9P8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CART family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9P8"/>
    <dbReference type="Ensembl" id="ENSMZET00005019372.1">
        <property type="protein sequence ID" value="ENSMZEP00005018769.1"/>
        <property type="gene ID" value="ENSMZEG00005014079.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018319"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008343">
        <property type="term" value="P:adult feeding behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032099">
        <property type="term" value="P:negative regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.30">
        <property type="entry name" value="CART, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009106">
        <property type="entry name" value="CART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036722">
        <property type="entry name" value="CART_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16655">
        <property type="entry name" value="COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16655:SF5">
        <property type="entry name" value="COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06373">
        <property type="entry name" value="CART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64546">
        <property type="entry name" value="Satiety factor CART (cocaine and amphetamine regulated transcript)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018257145" evidence="5">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="112" mass="12607" checksum="8E1569171B02B595" modified="2019-02-13" version="1">MGGSCACLFCTILCATGLLYGCGHVQAEEYETKYFTYFTTKEDGNEKQLISDLHDVLERLQNHPFPVLRKKHGYLPVCDPGEQCALRKGSRIGKLCDCSLPRTCNSFLHRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CA51</accession>
    <name>A0A3P9CA51_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AT-rich interactive domain 1B</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="protein sequence ID" value="ENSMZEP00005018924.1"/>
        <property type="gene ID" value="ENSMZEG00005014174.1"/>
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        <property type="component" value="LG15"/>
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        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="term" value="F:nucleosome binding"/>
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        <property type="term" value="P:chromatin remodeling"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:swimming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARID_dom"/>
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        <property type="entry name" value="ARID_dom_sf"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="BAF250/Osa"/>
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        <property type="entry name" value="BAF250_C"/>
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    <dbReference type="PANTHER" id="PTHR12656:SF11">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01388">
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        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="PROSITE" id="PS51011"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CA58</accession>
    <name>A0A3P9CA58_9CICH</name>
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            <fullName evidence="27">Heme-binding membrane glycoprotein gp91phox</fullName>
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        <alternativeName>
            <fullName evidence="28">Neutrophil cytochrome b 91 kDa polypeptide</fullName>
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        <alternativeName>
            <fullName evidence="23">p22 phagocyte B-cytochrome</fullName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="31">Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. NADPH oxidase complex assembly is impaired through interaction with NRROS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>NADPH + 2 O2 = 2 superoxide + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63180"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="2">Multi-pass membrane protein</topology>
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        <property type="term" value="P:superoxide anion generation"/>
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        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cytochrome b-245 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_b245_heavy_chain"/>
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    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
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    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
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    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
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    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
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    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF60">
        <property type="entry name" value="CYTOCHROME B-245 HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
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    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
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        <property type="entry name" value="Riboflavin synthase domain-like"/>
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    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
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    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="20 34" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="16 34" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="51"/>
            <end position="71"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="102"/>
            <end position="120"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="165"/>
            <end position="189"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="35">
        <location>
            <begin position="282"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022982"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
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            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
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            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00030106"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042446"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00042476"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00042502"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042961"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="565" mass="64723" checksum="693DC2971318557C" modified="2019-02-13" version="1">MGNFIANEGLSVFVILVWLGINAFLFVHFYMAFLVERWYYTRVLLGQALPWARAPAACLNFNCMLILLPVCRNLLSFLRGTIQCCSRTAARQLDRNLTFHKLVAYMIAFHTAVHIIAHLFNFEFFMDAQLNRNTSLLTFVLSEIGNGDNAAFLNPIRTNETNPTIVMFTTVAGLTGVAITLALILIITSSMEVIRRSYFEVFWYTHHLFIIFFIGLVFHGYARIVRGQTVASLDTNKPQNCSDKFEDWGKNGSNCAVPEFAGNPPGTWKWVLGPMILYVCERIVRIYRSHQKVVITKVVMHPSKTLELQMKRKGFSMEVGQYVFIQCPSVSRLEWHPFTLTSAPEEDYFSAHIRIVGDWTQALYEACGGDKNEPQEAWKLPKVAIDGPFGTASEDVFRYEVVMLVGAGIGVTPFASILKSVWYKRIQKNQDVFTKKIYFYWLCPETQAFEWFADLLQSLEGQMTEKNMMGFLSYNIYLTRWKEQEAAHFRVHHEAENDPITGLKQKTFYGKPNWDNEFTNITSQHPRSKVGVFLCGPPQLATSLEKQCMSHSAADVKFIFNKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBJ9</accession>
    <name>A0A3P9CBJ9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Hyaluronidase</fullName>
            <ecNumber evidence="21">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases. Essential for the breakdown of extracellular matrix hyaluronan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with MST1R.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17 21">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="21"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBJ9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019680"/>
    <dbReference type="GlyCosmos" id="A0A3P9CBJ9">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005020310.1">
        <property type="protein sequence ID" value="ENSMZEP00005019680.1"/>
        <property type="gene ID" value="ENSMZEG00005014772.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230364"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033906">
        <property type="term" value="F:hyaluronoglucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000065">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF6">
        <property type="entry name" value="HYALURONIDASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038193">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018084063" description="Hyaluronidase" evidence="22">
        <location>
            <begin position="27"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="19">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="51"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="470" mass="53738" checksum="D721FABDF8564992" modified="2019-02-13" version="1">MLHGTLSAWKALLLIVPLWDCLFALGLQPTRWPLYSRKPLLLAWNAPIEDCAPRHRIHFQLDQFQIVATPNEGFVNQNLTIFYKERLGLYPYFEQDETPVNGGLPQVASRTRHLEKMPEDVKKYIRSEWATGLAVIDWEDWRPLWIRNWEAKDIYRRHSEELVRQKNPTWLPDQVKKVAQQEFELSARLFMLDTLKQAKNLRPNQLWGFYLFPDCYNHNYVRTLESYTGRCPDVEVSRNDQLKWLWTESTALFPSIYMSSLLRSSAAGRQFVRNRVKEGMRLASSGDGLARPVFVYTRPTYMNSLEQLTETDLVSTIGESVALGAAGIIMWGDIAYAHNKTTCSDLDKYLRGTLSQYLLNVSTAAELCSQTLCGSHGRCLRRNSNSDVYLHLNPLTHDIVEKNGKLTVTGELGKADGLSFEADFQCQCYSGYQGELCDQTDPLHQKGTATRATAVALRCLILLIVCLLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBX9</accession>
    <name>A0A3P9CBX9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lymphatic vessel endothelial hyaluronic receptor 1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004543215.1">
        <property type="nucleotide sequence ID" value="XM_004543158.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBX9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019793"/>
    <dbReference type="Ensembl" id="ENSMZET00005020427.1">
        <property type="protein sequence ID" value="ENSMZEP00005019793.1"/>
        <property type="gene ID" value="ENSMZEG00005014853.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486748"/>
    <dbReference type="KEGG" id="mze:101486748"/>
    <dbReference type="CTD" id="560618"/>
    <dbReference type="GeneTree" id="ENSGT00530000063822"/>
    <dbReference type="OrthoDB" id="9938473at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005540">
        <property type="term" value="F:hyaluronic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043210">
        <property type="entry name" value="CD44_antigen-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000538">
        <property type="entry name" value="Link_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10225">
        <property type="entry name" value="HYALURONAN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10225:SF2">
        <property type="entry name" value="LYMPHATIC VESSEL ENDOTHELIAL HYALURONIC ACID RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00193">
        <property type="entry name" value="Xlink"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01265">
        <property type="entry name" value="LINKMODULE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00445">
        <property type="entry name" value="LINK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01241">
        <property type="entry name" value="LINK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50963">
        <property type="entry name" value="LINK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018045407" evidence="12">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Link" evidence="13">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="269" mass="29865" checksum="A1A10F35B1AF4952" modified="2019-02-13" version="1">MNIIWLCLPAALLVTSALSVQMTDIRNLRVSPGFNQSIAGVMLVTSLNELNQPEYAFNASEARRLCWSFGLNIASKAQVQKALSRGLETCRFGWIDEHFAVIPRIHPIPSCGRNKSGLVPWRASVKQKFDVFCFNETDAAIQRMDEVTDSPLKSTHGVGHTHHTTTPPSTSSSSTPETLDSEIEPARFASSSQSFTAGKAVLIFCSCALLLLITIILTYLKLRRCSQKSDVKEQKEYIQTEEWICVKTPTETKKAAEEDERIEVGDDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDM1</accession>
    <name>A0A3P9CDM1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Calcium/calmodulin-dependent protein kinase 1Da</fullName>
        </submittedName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014266290.1">
        <property type="nucleotide sequence ID" value="XM_014410804.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDM1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020363"/>
    <dbReference type="Ensembl" id="ENSMZET00005021015.1">
        <property type="protein sequence ID" value="ENSMZEP00005020363.1"/>
        <property type="gene ID" value="ENSMZEG00005015262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487616"/>
    <dbReference type="KEGG" id="mze:101487616"/>
    <dbReference type="CTD" id="100144566"/>
    <dbReference type="GeneTree" id="ENSGT00940000156776"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14168">
        <property type="entry name" value="STKc_CaMKI_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000203">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="438" mass="48363" checksum="10FFD00FA0D12C72" modified="2019-02-13" version="1">MARENGDTTGRGETWKKQVDDIKKIFDFKEVLGTGAFSEVVLAQEKLTSRMFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPDHLYLIMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVNYLHRMGIVHRDLKPENLLYFNPQDESKIMISDFGLSKMEGSGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKADYEFDAPYWDDISDSAKDFISRLMEKDPAKRFTCEQALRHPWIAGDTALCKNIHESVSRQIRKNFAKSKWRQAFNATAVVRHMRRLQLGSSMGSSIDASNAPTRPSQTQKSAQSQSQAGQNQPAQSQNTGQTAQSQSTSAVASKISSIDNNIAAPHKDCVTAPVTPCSLASAASSPATGTELNRPHPSAVPAPVLTETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDU5</accession>
    <name>A0A3P9CDU5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cyclin-dependent kinase 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cell division protein kinase 10</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014264835.1">
        <property type="nucleotide sequence ID" value="XM_014409349.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014264836.1">
        <property type="nucleotide sequence ID" value="XM_014409350.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014264837.1">
        <property type="nucleotide sequence ID" value="XM_014409351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDU5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020066"/>
    <dbReference type="Ensembl" id="ENSMZET00005020713.1">
        <property type="protein sequence ID" value="ENSMZEP00005020066.1"/>
        <property type="gene ID" value="ENSMZEG00005015057.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469232"/>
    <dbReference type="KEGG" id="mze:101469232"/>
    <dbReference type="CTD" id="8558"/>
    <dbReference type="GeneTree" id="ENSGT00940000158102"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035173">
        <property type="term" value="F:histone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07845">
        <property type="entry name" value="STKc_CDK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000289">
        <property type="entry name" value="cyclin-dependent kinase 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000256">
        <property type="entry name" value="cyclin-dependent kinase 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044093">
        <property type="entry name" value="STKc_CDK10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="40"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="360" mass="41040" checksum="3BD0E6D1D147AB31" modified="2019-02-13" version="1">MDAAGEDEPDPIKLKSLKDNKTFTVPQNYRFGSCRSVREFEKLNRIGEGTYGIVYRARDTKSDEIVALKKVRMDAEKDGVPISSLREITLLLRLRHPNIVELKEVVVGTQLESLFLVMSYCEQDLASLLENMQTPFSEAQVKCIVLQLLRGLEYLHHNFIIHRDLKVSNLLMTDKGCVKIADFGLARMYGIPQQPMTPRVVTLWYRAPELLLGTKTQTTALDMWAVGCILAELLAHKPLLPGTSEIQQVDLIVQLLGTPNENIWPGFSQLPLIGQYSLRKQPYNNLKNKFTWLSDAGHRLLNLLFMYNPQRRATAKDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPPAESHSKRSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEF5</accession>
    <name>A0A3P9CEF5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Synaptic vesicle 2-related protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEF5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020532"/>
    <dbReference type="Ensembl" id="ENSMZET00005021198.1">
        <property type="protein sequence ID" value="ENSMZEP00005020532.1"/>
        <property type="gene ID" value="ENSMZEG00005015390.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155403"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17441">
        <property type="entry name" value="MFS_SVOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000084">
        <property type="entry name" value="Synaptic vesicle 2-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047969">
        <property type="entry name" value="SVOP-like_MFS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="89"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="552" mass="61108" checksum="C71D93784C8D4558" modified="2019-02-13" version="1">MNTKMDDDLFQLRQLPVVRFRRTGESTRSEEDVESREQDARTAEQTDLEAVALTEGAPVPREFANPTDDTFMVEDAVEAIGFGTFQWKLSILTGLSWMADAMEMMILSILAPQLHCEWRLPSLEVALLTSAVFIGMMISSSLWGNISDKYGRKTGLKLSVLWTMFYGLMSAFAPIYGWILVLRALVGFGIGGAPQSVTLYAEFLPMKSRATCILLIEIFWALGTVFEVLLAILVMPTLGWRWLLGLSTIPLFIFAILCFWLPESARYDVLTGNQEKALNTLKRIATENGAPMPLGKLIAARQEDRGKIQDLFSSHFRWTTVLLWFIWFANAFSYYGLVLLTTELFQEGGACGMSKGNKEELRCSLECKYLNSDDYKDLLWTTLSEFPGLLVTLWAIDRLGRRKTMALCFFVFSMCIIPLYGCVGRASMTVLIFIARAFIAGGFQAAYVYTPEVYPTATRALGLGTSSGMARVGALITPFVAQVMLESSVYLALSVYCCCCLFAAIASCALPIETTGRGLQESSHREWGQEMMGRASSHSAGGVPDSSSGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEN0</accession>
    <name>A0A3P9CEN0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L1 transposable element RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEN0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020494"/>
    <dbReference type="Ensembl" id="ENSMZET00005021150.1">
        <property type="protein sequence ID" value="ENSMZEP00005020494.1"/>
        <property type="gene ID" value="ENSMZEG00005015366.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000177317"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1820">
        <property type="entry name" value="L1 transposable element, RRM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="L1 TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="32403" checksum="ADCA52BD79A7D11A" modified="2019-02-13" version="1">MTTVKGGIESLKEAGNSLGARVDETETRISRLEDEEAKASSISKNLKIQNQRLQEKVTVLEGFSQRQNIRISGIRDGTEGRNLEDCVKHLLSEALDIEMGDYYEIDRIHRVGPAPPKPAADSRPRHIIVRFLWDKAKMSVLAAARKKKQIIWKGMRVCFFQDYAQEVQEKRRKFDEARRLLQQCNIGYSLRFPAVMTFSVDNQYHSIISFPTQDKLMKLEQDIKELEKQHMLHPERDLWNKLIKFNFEMNSILMTRWRRARVQWLLALQFGARFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CES8</accession>
    <name>A0A3P9CES8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydropyrimidinase like 5a</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CES8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020544"/>
    <dbReference type="Ensembl" id="ENSMZET00005021208.1">
        <property type="protein sequence ID" value="ENSMZEP00005020544.1"/>
        <property type="gene ID" value="ENSMZEG00005015198.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234527"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000217">
        <property type="entry name" value="Dihydropyrimidinase-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF58">
        <property type="entry name" value="DIHYDROPYRIMIDINASE-RELATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="488" mass="54327" checksum="0AA52C38B8AD417E" modified="2019-02-13" version="1">MFPLPRRSIAMSSSSAMVRILIKGGKVVNDDCTRRLMFTSRRHRPAGGEELMIPGGAKVIDESFMNATTVDDFYSGTKAALAGGTTMVIGHVLPERNESLLEAYEKCRNSADSKACCDYALHIGVTWWGPKMEKLVRDKGVNSFQMFMAYKDMFMLRDSELFQVLQHCKDIGAIARVHAENGELVSEVRDLLGITVCAHCPVYLVNVSSMSAGDVVATAKMQGEALYLLYLVLLSLNDTLNVVGSDHRPFTVKQKAMGKDDFTKIPHGLPGIQDRMSVIWERGGKMDENRFVAVTSSNAAKIYNLYPRKGRIIPGADADVVVWDPEGSKVISVKTRCREVILTRMKVCALPGVPIVTISRGRLVYENGMFTCAEGSGKFCPLRTFPDYLYKKMVQREKGIMFTYHICFCRGLVDKKLVKGSPSFHAPLVLHVPTTRSMPMEKVRRHTVQCALKVLSCTFPARCFPFPIPPCTFAAFFFLSLSEQTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF98</accession>
    <name>A0A3P9CF98_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Nuclear pore complex protein Nup93</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004569200.2">
        <property type="nucleotide sequence ID" value="XM_004569143.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012779558.2">
        <property type="nucleotide sequence ID" value="XM_012924104.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CF98"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020950"/>
    <dbReference type="Ensembl" id="ENSMZET00005021637.1">
        <property type="protein sequence ID" value="ENSMZEP00005020950.1"/>
        <property type="gene ID" value="ENSMZEG00005015710.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101478010"/>
    <dbReference type="CTD" id="9688"/>
    <dbReference type="GeneTree" id="ENSGT00390000016353"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="820" mass="93336" checksum="A8E7D04FEBA89400" modified="2019-02-13" version="1">MDTEGFGELLQQAEQLAAETEAVSELPHVERNLQEIQQAGERLRSRTLTRTSQDAADVKASILLGSRGLDIFHISQRLESLSAATTFEPLEPVKDTDIQGFLKNERDNALLSAIEESRRRTFLLAEEYHRESMLVQWEQVKQRVLHTLLGAGEDALDFSQDVEPSFVSEVTAPGRSALDSVEVAYGRQIYIFNEKIVNGHIQPNLGDLCASVAESLDDKNVSELWLMVKQMTDVLLVPAKDTLKSRTSVEMQMAFVRQALAFLENSYKNYTMVTVFGNLHQAQLGGVPGTYQLVRSFLNIKLPGPLPGMQDGEIEGHPVWAVIYYCLRCGDLHAAMQVVNRMQHQLGDFKTWFQEYMKSPDRRLSPTSENKLRLHYRRVLRNCADPYKRAVYCMIGKCDINDNHGEIADKTEDYLWLKLNQVCFDDDGSSSPQDRLPLPQLQKQLLEDYGESHFSASQQPFLYFQVLFLTAQFEAAVAFLFRVERLRSHAVHVALVLYELRLLLKSTGQSAQLLSQEPGDPPMVRRLNFIRLLMLYTRKFESTDPREALQYFYFLRNEKDNQGENMFMRCVSELVIESREFNMLLGRLEKDGSRKPGVIDKFAGDTRAIISKVALEAENKGLFEEAVKLYELAKNSDKVLELMNRLLSPVIAQVSAPQSNKERLKNTAVAIAERYRSQGVAGDKSVDSTFYLLLDLMTFFDEYHAGHVDRAYDVMERLKLLPLSQDSVEERVAAFRNFSDEVRHNLSEVLLATMNILYTQYKRLKGAPAGTPGRPQRTMEDRDTQLRGQARALITFAGMIPYNMAGDTNARLVQMELLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFS0</accession>
    <name>A0A3P9CFS0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CFS0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020706"/>
    <dbReference type="Ensembl" id="ENSMZET00005021388.1">
        <property type="protein sequence ID" value="ENSMZEP00005020706.1"/>
        <property type="gene ID" value="ENSMZEG00005015533.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155279"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000428">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000002">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="419" mass="44925" checksum="1F9205E59E1CF327" modified="2019-02-13" version="1">MLAVSAVVLPCLACHPITTTLSSLSDSNTSFLRAARAGNVDKVLEYLKGGVDISTCNQNGLNALHLAAKEGHIDLVQELLDRGAAVDSATKKGNTALHISSLAGQADVVKILSKRGADINAQSQNGFTPLYMAAQENHLDVVRYLLENGGNQSIATEDGFTPLAIALQQGHNQVVSVLLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVRLLLDRGSQIDAKTRDGLTPLHCAARSGHDTAVELLLERGAPLLARTKNGLSPLHMAAQGDHIECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALRNSRILPLTAAHLHQGKPPPAPLLLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CHX5</accession>
    <name>A0A3P9CHX5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SH3 domain-binding glutamic acid-rich-like protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CHX5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021639"/>
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        <property type="protein sequence ID" value="ENSMZEP00005021639.1"/>
        <property type="gene ID" value="ENSMZEG00005016236.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157260"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GRX_SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF15">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3BGR"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="92" mass="10242" checksum="6AA3619924253648" modified="2019-02-13" version="1">EMPVKVFFTSVSGSTQIKKNQERVFSILNAKKIPFQPVDISQSSDDKDLMRQGAGDPTALPPQIFNGDVYCGDISAFDNAIEMEQLEDFLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CKQ7</accession>
    <name>A0A3P9CKQ7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0606 protein KIAA1549</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="STRING" id="106582.ENSMZEP00005022682"/>
    <dbReference type="Ensembl" id="ENSMZET00005023432.1">
        <property type="protein sequence ID" value="ENSMZEP00005022682.1"/>
        <property type="gene ID" value="ENSMZEG00005016968.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063472"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024606">
        <property type="entry name" value="KIAA1549"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21590">
        <property type="entry name" value="SEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21590:SF4">
        <property type="entry name" value="UPF0606 PROTEIN KIAA1549"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12877">
        <property type="entry name" value="KIAA1549"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1424"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1642" mass="178590" checksum="722020A8CF959C4F" modified="2019-02-13" version="1">MISLELASFSVIVSIYEFPYVSCTDTKHCLCSSADESPLDSTHDPMGFLGDIQSPTSSPLALPDSHYTAFESLDSPGALPSNPEPSHEVRTADNIHRGHIAYENSKVIMLRDASAEEPHTLTTPTLRPSVPQFQRPAELSLGWKLARSSLSEAQTKSQLQPWENISITSVKPSPTPQLGLNSEKRMTFQPEGPLGPPIQTFTDLLAEDSHMKPMHADQLSSSNPPLENKHAYDINMLPNPDEIQSPGYKVPFITPHPASPSSEPTELSPEDFYPTNTMEVDWGSGDYLETMSFFNADREDYSLVTKVPSDSYDLEDYTETYDTSFPSRVGISPSSLNPLYVSPSPSLVTAYSTVVSPRSIYPSSFSATVQFSLEPTPTPNSDVPDISDVDWSDTYTIQPTDVLLPDMNSLEYYNNQLTKENNGSESGAEHRGNITVVSISTTDSTPNNSFSNDTKVIEEESSSDLSGLEPHDETSFVVTTEESPQVANASQPFLDPSIVPTHSLHSFSSSDGQVSTTDWSAHTNNVGLDSTPITEAVQPSTTPLLADDLNFASSLTYVHWYVTESPPKSTMDATAVLTATIDFSPVPTEPAANSTAGTTELAPEESAFTNDPTLNATIVSTESTPQNVTLPPPFVMGDQGVTEDGVDTPATLTYIPTSSVVNKVSTTPTSTPATTTPHQATSRITATSEASTIVNIISTTVGKITAIAPTSRSYLCNVNKPAYLIRIGKLAVSGPVVYTGMSVVNALRRSGRRFLSVSPNWSTPDRNYQVHSVLQFVPGHVDVRFCNFSESIERGLTRAFAEVRRRSKESTNFTVHIVNITMAAPIYEEQGLARKPVDITFTVRSSRSYLMGSEISSALMKLTMVEFSYYMGFPVLQIAEPFNYPELNTSQLLRSSWVRTVLLGVLDQKVGERTFQANMERRLALLLGEAIGSVRRVKRATTIGNSSVQVVSTSRLAGTDLPLEIVYFVEGPSGQRMPADQTASLLNSLDVQRAAIVLGYRVQGILAQLQVNQTLPLTSSPSDNENTNMWIIIGVVIPLLVVVVIISILYWKLCRTDKLEFQPDAMTSIQQRQKLQAPTVKGFDFAKLHLGQQSKDDVMVIQEPVPSGLGPVQVSIKDGLSPSENGEIPTPISKTSASSTKASRSGRRRGRSVISSSDGDSVLSDHSSERESTEENLRAQATPSPPPMNDTNEQLSSASIFEHVDRISRGTDASRRLPNKVQLIAMQPMPVPPLHSPPVNGKLSDTNQMTKEIQVALRHKSEIEHHRNKIRLRAKRKGHYDFPAMDDIGGLGDAKDPDRIYRKEQMQIDKILDPDAQMPSVFMEPKKSGRGRRSPKQRMKDQMNGGMMEADKDHLITEDTDAAYRKCPGVNNVAYSDPDQAPTSSPPGHAPPPPPYMPPQPSIEEARQQMHSLLDDAFALVSPTSQGSTAGITLPGVNSNPPNSSPPGHGPRPWGLSYQAFPSVSCRLCTNFFGLCFRQGLGSSYLPPGETAGHGEQLQPDSLYSSRGLYADELPSSARPRPVGGTTGAQLHHLAQVGLSSRMNGFPAGVRAAPGQNGGLGWNHYHDDNFSRAEAEKDAVSEFGIREPTAPPTHLDGVGYLTAPPPLDTSPPTHSSASLIKAIREELLRLSQKQAAVPSYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLF0</accession>
    <name>A0A3P9CLF0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cilia- and flagella-associated protein 206</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP206 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLF0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022907"/>
    <dbReference type="Ensembl" id="ENSMZET00005023659.1">
        <property type="protein sequence ID" value="ENSMZEP00005022907.1"/>
        <property type="gene ID" value="ENSMZEG00005017149.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00740000115564"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003356">
        <property type="term" value="P:regulation of cilium beat frequency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901317">
        <property type="term" value="P:regulation of flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021897">
        <property type="entry name" value="FAP206"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21442:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="306" mass="35491" checksum="2133754E537E8FF0" modified="2019-02-13" version="1">MIKEVSTSMKYIQTYLDRIQKGKFKKSLKFGQYCPVCMALHYHLVDISETAALTHAAEYRGHYFKMCDENHLEMFLSTPDQFVTPGCPHTLPKPHLLPRKLTEIHVKNRFPQQVEMKGYCPVTYLDGKQRYEALVRGKMEYAVEYRERIYIFETKEKRDKFMRTPETYWAQKLPIKVPPLSEPVHLTSLPTLGYLEQGVAEAVIKAMTAAGCLKPKHPYLSLKRSALSYVALYLKAFNHRSTDSIRQMYKKKLASFEENCMLIPYLSTVMKGNYRPPSERPIDFEFKLNRFLALSDLPGANGVQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLV2</accession>
    <name>A0A3P9CLV2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAGUK p55 scaffold protein 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLV2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023323"/>
    <dbReference type="Ensembl" id="ENSMZET00005024087.1">
        <property type="protein sequence ID" value="ENSMZEP00005023323.1"/>
        <property type="gene ID" value="ENSMZEG00005017460.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156444"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06799">
        <property type="entry name" value="PDZ_MPP3-MPP4-MPP7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="101"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="234"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="438" mass="50443" checksum="DAAEB619F29247D7" modified="2019-02-13" version="1">MPEDLPDDEEATRIICLVKNKQPLGATIKRNEITGEIFIARVIHGGLADRSLLHAGDRIIEVNGFPVDGMEPEQVIQVVARSHGTIMFKVIPITERPVHNQTMLYVRAMTDYSPQQDPAIPCADAGMSFRRGDILEIVDQTDALWWQAKKLPSSTACAGLIPSTNLLKRSQREFWWSQPYQPHTCIQTCMRLCRRRAHSTTQPSCNTRCPSSCYSALNSPYEEVVRYQRHSEDVHRLIVLLPSGVGVNELRRRLVEMNPNIFQGPVPTTRAPRGYEESGREYFFISREVFENMVYHNFLEYGEHKGNMYGTSIESAKEVLNSGKICVIDIEPNARTHELRAFVIYVKPPTLERLRETRQDSYITTNYYVNRPFKQDEDFQEMEEAARKIESNYWQFFDHVIINNELQDSCVELLTAVMRAQDEPQWVPASWIRPTSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMJ7</accession>
    <name>A0A3P9CMJ7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CKLF-like MARVEL transmembrane domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_014266425.2">
        <property type="nucleotide sequence ID" value="XM_014410939.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMJ7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023036"/>
    <dbReference type="Ensembl" id="ENSMZET00005023793.1">
        <property type="protein sequence ID" value="ENSMZEP00005023036.1"/>
        <property type="gene ID" value="ENSMZEG00005017256.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101472908"/>
    <dbReference type="CTD" id="54918"/>
    <dbReference type="GeneTree" id="ENSGT00940000157911"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF25">
        <property type="entry name" value="CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="8">
        <location>
            <begin position="25"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="183" mass="20232" checksum="7D8DAE367BBCE99E" modified="2019-02-13" version="1">MAEPVYTPTTTPNPGNSFCLIPSAHLDRNRFILKVVEVVLSFIAFILEETVDSCFTCSPLYFFEFVSCTAFLFTLLLLVLLSTKLHEKIHIGAWPTVDMIYTGVIAVLLFISSCIFAADRGSLVQATVAVVFGFLATVAFSIDFGLMVKSKGLPFLNKDKKQEHTNGIQTPAEEERLKANETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CMP1</accession>
    <name>A0A3P9CMP1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CMP1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023613"/>
    <dbReference type="Ensembl" id="ENSMZET00005024387.1">
        <property type="protein sequence ID" value="ENSMZEP00005023613.1"/>
        <property type="gene ID" value="ENSMZEG00005017662.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000193911"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF30">
        <property type="entry name" value="SYNTAXIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="103" mass="11900" checksum="11D98595294AAB21" modified="2019-02-13" version="1">MKEIHELFLQMAILVEEQGSMLNNIEAHVCNTVEYIEKVHVHMKKAIQYKRKNPFLQSVAINKGLILILLVIIYVLNLIICLSSCLVLFVVVYQSCYMNKVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CNE3</accession>
    <name>A0A3P9CNE3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GDNF family receptor alpha 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CNE3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023316"/>
    <dbReference type="Ensembl" id="ENSMZET00005024080.1">
        <property type="protein sequence ID" value="ENSMZEP00005023316.1"/>
        <property type="gene ID" value="ENSMZEG00005017454.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165282"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014707">
        <property type="term" value="P:branchiomeric skeletal muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.110:FF:000001">
        <property type="entry name" value="GDNF family receptor alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.110">
        <property type="entry name" value="GDNF binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF15">
        <property type="entry name" value="GDNF FAMILY RECEPTOR ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01316">
        <property type="entry name" value="GDNFRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GDNF/GAS1" evidence="10">
        <location>
            <begin position="63"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="10">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="10">
        <location>
            <begin position="269"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="417" mass="46984" checksum="6F3529253A9D8C6D" modified="2019-02-13" version="1">MLAHNLLHPLLSALPSLPFSISAFPRPPPHMTFLVSDVNFFAFLGVLPSSASIFNFPAPTIDCVEAHRVCSVEPTCEALYRGLELCAEDAAVSPQAEQLASECVERRDALLAKHPSLLTCKCQRGFRKEELCLRIYWRVRLLPGEEELETSPYDDMLVDTHMASLVAGKTHTDKHMCLKAAQDCGLYEKCGNLRSEYVLACTKPMPGTNRCNQHKCHRSLRRFLERVPEEYSLGVLFCRCTDTLCGERRRKTIVPSCSYHDKEGLQLNCLHQQSFCRRDDLCRSRLADFLNNCQPSHLTASGCLKDSAGLCLRAYAGLIGTIMTPNYISNSSADVSLWCNCEGSGNQWQECLKLQRIFTHNSCLRESTVHTFHIHQLERSWYKDAKFSVMFITKNLDIVCLHSSLFSILGAFGLGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CP39</accession>
    <name>A0A3P9CP39_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CP39"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024110"/>
    <dbReference type="Ensembl" id="ENSMZET00005024900.1">
        <property type="protein sequence ID" value="ENSMZEP00005024110.1"/>
        <property type="gene ID" value="ENSMZEG00005018033.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165266"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF7">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="149"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="385" mass="43883" checksum="401ECC2FCB54CE54" modified="2019-02-13" version="1">STDRKSACQISLGKILTPSCSPMHPSEYECDGYQGRLQISKEELENVLSLKTSFTEAASILSISRPILYKLLQDYNISESKFNVISDHELDQIVSQIKTEHPNVGEVMLMGHLRSKNIVVQRWRVRKSLRRVDSAGVLSRRRTAVARRVYSVPHPNFIWHIDGNHKLIRWKFVVHGAIDGYSRMLMFLQCSSNNRAETVKALFTAAVGQFGRPLHIRTDHGGENAQIWEDMRASRGESSVLMGSSVHNQRIERFNRDLNNNCSRIYAPIFYELESLGILDLENATDLFCLHYVFLPRINRTLKEFKAGYNNHSVSTEGNRTPIQLFACGTHVSHRHNPELSTAEVSIPSLSNSESRFCPCLKKKSLIKLLYYTSDFIDLSLKIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CSV7</accession>
    <name>A0A3P9CSV7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 9</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN9 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CSV7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025445"/>
    <dbReference type="Ensembl" id="ENSMZET00005026269.1">
        <property type="protein sequence ID" value="ENSMZEP00005025445.1"/>
        <property type="gene ID" value="ENSMZEG00005018988.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000076"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029391">
        <property type="entry name" value="CSN9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28562">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15004">
        <property type="entry name" value="MYEOV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0736">Signalosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="55" mass="6003" checksum="A86553DDD1195D25" modified="2019-02-13" version="1">MKPAVDEMFPEGAGPYVDLDEAGGSSGLLMDLAANEKAVHSDFFNDFFTSFEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CU42</accession>
    <name>A0A3P9CU42_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemokine interleukin-8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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                <person name="Bezault E."/>
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                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
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                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
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                <person name="Gante H.F."/>
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        <source>
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                <person name="Turner-Maier J."/>
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                <person name="Penman D.J."/>
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                <person name="Venkatesh B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUT7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025591"/>
    <dbReference type="Ensembl" id="ENSMZET00005026420.1">
        <property type="protein sequence ID" value="ENSMZEP00005025591.1"/>
        <property type="gene ID" value="ENSMZEG00005019096.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230367"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015095">
        <property type="entry name" value="AlkB_hom8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09004">
        <property type="entry name" value="ALKBH8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="317" mass="35963" checksum="4A1DB784325CBDE7" modified="2019-02-13" version="1">MLFVDYSSAFNTIVPSKLDRKLQDLGLSSSLCSWILSFLSDRRQVVRLGSITSSPITLNTGAPQGCVLSPLLCSLYTYDCTATNSSNIIVKFADDTTVVGLITNGDETAYREEVSALTHWCQDNHLTLNVAKTKELTVDFRRCREVHTPITINGAAVERVSSFRFLGVHLAEDLTWSVHTNKTVKKAQQRLFFLRRLKRFGMSPRILRTFYHCAIESILTGCITTWYGNSTAYNCKALQRVVRCSERIIGGELPSLQDIYRKRCLRKAGRIIKDSSHPSHKLFRLLPSGRRFCSIRSRTSRLRDSFFHQAIRLLNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CUX6</accession>
    <name>A0A3P9CUX6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidine phosphorylase</fullName>
            <shortName evidence="5">TP</shortName>
            <ecNumber evidence="5">2.4.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">TdRPase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>thymidine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.4" evidence="5"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CUX6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005025631"/>
    <dbReference type="Ensembl" id="ENSMZET00005026464.1">
        <property type="protein sequence ID" value="ENSMZEP00005025631.1"/>
        <property type="gene ID" value="ENSMZEG00005019135.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009250"/>
    <dbReference type="UniPathway" id="UPA00578">
        <property type="reaction ID" value="UER00638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000003">
        <property type="entry name" value="Pyrimidine-nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="entry name" value="Pyrimidine nucleoside phosphorylase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004490">
        <property type="entry name" value="PRK05820.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515:SF0">
        <property type="entry name" value="THYMIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="Pyrimidine nucleoside phosphorylase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyrimidine nucleoside phosphorylase C-terminal" evidence="6">
        <location>
            <begin position="355"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005025631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="452" mass="48427" checksum="CA19EBA73A479D00" modified="2019-02-13" version="1">MITIPDLIRKKRDGGQLSDDEIKAFIQAVKEKTIQDSQTGAMLMAIWLNGMVSAEIKALTREMMSSGEVMEWPDEWKNFMVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLAHTGGTLDKLESIPGFKVEQSREQILEILDSVGCCIVGQTETLVPADRVLYALRDITSTVDSLPLVTGSIISKKGAESLFALVLDVKFGRAAICKDLESATELAQMLVEAGNGLGICTAAVLSGMNSTIGRCVGNSVEVIESLETLKGNRPDDLMELVTTQGGLLLVMTGLVSDLSEGRKQISEAVVGGAALSKFQAMMEAQGVNSDTAQLLCSTNADYYSILRKAKHQLELKAPADGIVLEIDGLVLAQVLHRLGAGRSKAGEPVNHSVGAVLLVSIGQRVTKGDPWLRLHYEDLALTPDQRNHLESALTVGADKKIQTQQKHTLVEKILPEKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVN6</accession>
    <name>A0A3P9CVN6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 79b</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVN6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026398"/>
    <dbReference type="Ensembl" id="ENSMZET00005027252.1">
        <property type="protein sequence ID" value="ENSMZEP00005026398.1"/>
        <property type="gene ID" value="ENSMZEG00005019701.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002390"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31004">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31004:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="400" mass="44601" checksum="260BC0882F22872C" modified="2019-02-13" version="1">MMEDSGGRKTREGEDEETVSSVVTETSTLPWSADRQTGGRTGKADRMSVRSGVFLPEASSCTESERELKAEVERRGGRAGLDEGAELREDKTRVHLLEEEPRENLLPEKAAQVFRPAVTALHSPSSLRESGPLREMESEKSPFLGPRGVPENYNQHYYLHEELRSNKRGQCCLSTDVLKMGVSLMASAFFFPLLVWGGFVFLPFDAPLLDGAPLRLVYTLRCSVFAATPIVLGESHTTEKEMQNLTCLTCVRLTCSLGWLVLGISRLRSGVLRPLFDDEIKEAELQEVTVHQRFISDSASLFLIYFLQLVVMAMYLSQEQLKLVPLLTILFAFGRLAYWVAAAFGSSIRGFGFGISFLPSIIMMGANFYFIFMMDAASSIFSVPHDEAPPQPAGRQRFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CYL9</accession>
    <name>A0A3P9CYL9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neuritin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CYL9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027428"/>
    <dbReference type="Ensembl" id="ENSMZET00005028301.1">
        <property type="protein sequence ID" value="ENSMZEP00005027428.1"/>
        <property type="gene ID" value="ENSMZEG00005020449.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990138">
        <property type="term" value="P:neuron projection extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026144">
        <property type="entry name" value="Neuritin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15902:SF1">
        <property type="entry name" value="NEURITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15902">
        <property type="entry name" value="NEURITIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15056">
        <property type="entry name" value="NRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="109" mass="12112" checksum="CECC22EF1E7AE7DA" modified="2019-02-13" version="1">MERNPTAAPKPINQPDPSNEPHARSHRVVLRVADGAGQCGQCDSVFKGFSDCLISWETTWNLHQICTYWDNFHSCATTALADCQEGICQRQGPRLGPNTLPTILTWLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D071</accession>
    <name>A0A3P9D071_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Porphobilinogen deaminase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D071"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027759"/>
    <dbReference type="Ensembl" id="ENSMZET00005028639.1">
        <property type="protein sequence ID" value="ENSMZEP00005027759.1"/>
        <property type="gene ID" value="ENSMZEG00005020696.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000182022"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="83" mass="9535" checksum="68795EB599F9FF7C" modified="2019-02-13" version="1">MEEGPYKYIRDGNGKVSRVIRVGTRKSQLARIQTDSVAETLKELYPDIHLEIVNGICLLQIGEKTCSPKSWRMHWRGMSKCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D114</accession>
    <name>A0A3P9D114_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Binds to MUC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D114"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027882"/>
    <dbReference type="Ensembl" id="ENSMZET00005028770.1">
        <property type="protein sequence ID" value="ENSMZEP00005027882.1"/>
        <property type="gene ID" value="ENSMZEG00005020793.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000193372"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000009">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018201317" description="AP complex subunit sigma" evidence="14">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="15">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="160" mass="19210" checksum="7559AB8F3ACE01B7" modified="2019-02-13" version="1">MPFLCLFMQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEAQETSKKNVLKAIEQADLLQEVRYVIKPPWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1K3</accession>
    <name>A0A3P9D1K3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GMPR</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8 11">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1K3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028239"/>
    <dbReference type="Ensembl" id="ENSMZET00005029137.1">
        <property type="protein sequence ID" value="ENSMZEP00005028239.1"/>
        <property type="gene ID" value="ENSMZEG00005021062.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101480382"/>
    <dbReference type="GeneTree" id="ENSGT00940000159574"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000012">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF4">
        <property type="entry name" value="GMP REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="285"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="314"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="348" mass="37619" checksum="2347A8600D2C3BE8" modified="2019-02-13" version="1">MPRIENDIKLDFKDVLLRPKRSTLKSRSEVDLMRSFTFRNSKGSYRGIPIIAANMDTVGTFEMAVALHQFTLFTTVHKHYTVDDWLEFAEKHPECLESVAVSTGTGDGDFEKISAVVEAVPQLKYICVDVANGYSEHFVHFVRDVREKFPSHTIMAGNVVTGEMVEELILAGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVIECADAAHGLGGHIISDGGCTCPGDVSKAFGAGADFVMLGGMLAGHSESSGEIIEKNGKKYKLFYGMSSDTAMKKHAGGVADYRASEGKTVEVLYKGPVGDTIRDILGGVRSTCTYVGAAKLKELSRRTTFIRVTQQLNTVFGNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D1Z0</accession>
    <name>A0A3P9D1Z0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Crystallin, gamma S3</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D1Z0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028126"/>
    <dbReference type="Ensembl" id="ENSMZET00005029022.1">
        <property type="protein sequence ID" value="ENSMZEP00005028126.1"/>
        <property type="gene ID" value="ENSMZEG00005020992.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163494"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000001">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000003">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF126">
        <property type="entry name" value="CRYSTALLIN, GAMMA MX,-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="179" mass="21583" checksum="8E3293C472382407" modified="2019-02-13" version="1">MKIYILSNIVFYEDRNFQGHYYECSSDCPELNAHFSHCNSIRVESGSWVLYERPNYMGYQYILTRGEYPHYQSWMGYNDSIRSCRIIRNTSGAFRVRVYERPDFSGQMLDCTEDENNLPDRWHHREVHSAQVQDGAWVFYELPNYRGRQYLLERGEYRRFNEWAAMSPNVGSFRRVHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D273</accession>
    <name>A0A3P9D273_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Neuropilin and tolloid like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D273"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028683"/>
    <dbReference type="Ensembl" id="ENSMZET00005029588.1">
        <property type="protein sequence ID" value="ENSMZEP00005028683.1"/>
        <property type="gene ID" value="ENSMZEG00005021386.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156700"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000463">
        <property type="term" value="P:positive regulation of excitatory postsynaptic potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000016">
        <property type="entry name" value="neuropilin and tolloid-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF27">
        <property type="entry name" value="NEUROPILIN AND TOLLOID-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018080314" evidence="6">
        <location>
            <begin position="17"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="160"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="544" mass="60715" checksum="4FC1FBE2D59E8E63" modified="2019-02-13" version="1">FIYVVASLLILGLCGATKKDTAVKPAGQCGTWVKEAEGGLFTSPNYPNKYPPDTECVYILEAPPRQCIDLHFDENYSIESSWECKFDNIEVRDGPFGFSPILGRYCGQHSPPDIRSSGRYLWIKFVTDGELEAVGFSASYNFTADPDFGDMGIPPPLPSCQYDMVGPEGIVESHQITRDGKAGATEAVDCKWYIRAPPRSKIYLRFLDYEMANSNECKRNFVAVYDGGSSVEDLKSKFCSTVANDIMLVSTLGVIRMWADEASRKSRFRILFTTYQEPPCDADAFFCHSNMCINNTLVCNGMQNCVYPWDENQCKEKRKANILDNLNNTNGTIIGVTCCIVFILLIISVIVQIKQPRKKYILRREDFDPTMFQEVFEPPHYELCTLRSATTPTAASADLVDLAEDFENYHALRRASSRCVHDHHCGSSSNPGSAHISQLSLSARESRGNLSARDAAAATLLTDLPQPSMAVRPLLPATGNRRSILVMKHSYSQEAADNGCDLDDDLEEVPTTSHRLSRHEKAVQRFCLIGSLSKHESEYNTTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D295</accession>
    <name>A0A3P9D295_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Large neutral amino acids transporter small subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">L-type amino acid transporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Solute carrier family 7 member 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)</text>
            <dbReference type="Rhea" id="RHEA:71811"/>
            <dbReference type="ChEBI" id="CHEBI:533015"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in)</text>
            <dbReference type="Rhea" id="RHEA:71823"/>
            <dbReference type="ChEBI" id="CHEBI:176514"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71824"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L-phenylalanine(in)</text>
            <dbReference type="Rhea" id="RHEA:71031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L-methionine(out)</text>
            <dbReference type="Rhea" id="RHEA:71055"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)</text>
            <dbReference type="Rhea" id="RHEA:71439"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-glutamine(in) + L-phenylalanine(out) = L-glutamine(out) + L-phenylalanine(in)</text>
            <dbReference type="Rhea" id="RHEA:71027"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)</text>
            <dbReference type="Rhea" id="RHEA:71003"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in)</text>
            <dbReference type="Rhea" id="RHEA:71011"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L-phenylalanine(in)</text>
            <dbReference type="Rhea" id="RHEA:71023"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-methionine(in) = L-leucine(in) + L-methionine(out)</text>
            <dbReference type="Rhea" id="RHEA:71051"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>L-phenylalanine(out) + L-alanine(in) = L-phenylalanine(in) + L-alanine(out)</text>
            <dbReference type="Rhea" id="RHEA:71043"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>L-phenylalanine(out) + L-methionine(in) = L-phenylalanine(in) + L-methionine(out)</text>
            <dbReference type="Rhea" id="RHEA:71039"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:71035"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>L-phenylalanine(out) + glycine(in) = L-phenylalanine(in) + glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:71047"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>L-tryptophan(in) + L-phenylalanine(out) = L-tryptophan(out) + L-phenylalanine(in)</text>
            <dbReference type="Rhea" id="RHEA:71007"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-valine(in) + L-phenylalanine(out) = L-valine(out) + L-phenylalanine(in)</text>
            <dbReference type="Rhea" id="RHEA:71019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)</text>
            <dbReference type="Rhea" id="RHEA:71107"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:190186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)</text>
            <dbReference type="Rhea" id="RHEA:71111"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:190186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)</text>
            <dbReference type="Rhea" id="RHEA:71103"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:190186"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004574210.1">
        <property type="nucleotide sequence ID" value="XM_004574153.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D295"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028226"/>
    <dbReference type="Ensembl" id="ENSMZET00005029124.1">
        <property type="protein sequence ID" value="ENSMZEP00005028226.1"/>
        <property type="gene ID" value="ENSMZEG00005021050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480678"/>
    <dbReference type="KEGG" id="mze:101480678"/>
    <dbReference type="CTD" id="100007704"/>
    <dbReference type="GeneTree" id="ENSGT00940000158278"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000008">
        <property type="entry name" value="large neutral amino acids transporter small subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004760">
        <property type="entry name" value="L_AA_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00911">
        <property type="entry name" value="2A0308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF113">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 35" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 35" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="34">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="34">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
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    <sequence length="527" mass="57248" checksum="1F341C09ECC09322" modified="2019-02-13" version="1">MTDGPRQRSSTAGSAKDGAAVKESGGGVALKKEIGLVSACGIIIGNIIGSGIFVSPKGVMENASSVGLALIVWIITGIITAIGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPENGLRVLAAVCLLLLTWVNCSSVRWATRVQDMFTAGKLLALALIIIMGVVQVCKGEYYWLEPANAFEPFQDYDVGLIALAFLQGSFAYGGWNFLNYVTEELVDPYVNLPRAIFISIPVVTFVYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSLLAMIHVTRCTPIPALLFTCLSTLLMLCTSDMYTLINYVGFINYLFYGVTVAGQIVLRIKQPDMHRPIKISLIWPVIYLLFWAFLLIFSLYSEPLVCGIGLAIMLTGVPVYFLGVYWDNKPQCFDAFVDKMTYVGQKFCMVVYPAESDSSSSGSGEEGEEMKEARAPLSKEDRDNRKSADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D332</accession>
    <name>A0A3P9D332_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Olfactory receptor 52E8-like</fullName>
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    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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        <scope>IDENTIFICATION</scope>
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        <property type="gene ID" value="ENSMZEG00005008042.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Odorant receptor 131-2"/>
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    <dbReference type="PANTHER" id="PTHR26451">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26451:SF998">
        <property type="entry name" value="ODORANT RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81321">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
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        </location>
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            <begin position="38"/>
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    </feature>
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    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="304" mass="35410" checksum="6F64FACCC05DBD26" modified="2019-02-13" version="1">MSASYTNETVVVNYRDAFPKAMVKNVIVVVLCISINYINVALLQTFCKQQIFYMNPRYILFFHLVLNDMIQVTLTVILFISSYIFFQINVSVCCVLILLALFATENTPLNLACMAVECYIAICIPLRHVQICTVKRTLMLIGLIWMTSMLSVLPDLFITLAIEPLDFYNSRVFCLRETVFRNPHIIKKRDITYIVYLVIVWFIIFFTYFKILFTAKAASQDATKARNTIILHGFQVLLCMSIYAEPLLRQVLQQWFPQNYSDSLFACYILFQILPRAISPIVYGVRDKTYRKYLKRYLLCKMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6G5</accession>
    <name>A0A3P9D6G5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004552294.1">
        <property type="nucleotide sequence ID" value="XM_004552237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6G5"/>
    <dbReference type="Ensembl" id="ENSMZET00005031220.1">
        <property type="protein sequence ID" value="ENSMZEP00005030270.1"/>
        <property type="gene ID" value="ENSMZEG00005022561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467189"/>
    <dbReference type="CTD" id="556314"/>
    <dbReference type="GeneTree" id="ENSGT00950000183060"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07912">
        <property type="entry name" value="Tweety_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF4">
        <property type="entry name" value="PROTEIN TWEETY HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="486"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="524" mass="59080" checksum="23FD1F69BD9B1EC1" modified="2019-02-13" version="1">MAAVVSYTPPWWVNLLHRLPHFNLRFEQTSSDFRPEDWTYQQSILLLGGVALACLALDLLFLLFYSIWLCCRRKKNEEQPNADCCCTAWCVIIATLVCSAGIAVGFYGNGETCDGVNRMTYSLRHANRTITGVQKLVYDSTSSLNQTVDDNLQQLEGQYAQHADYLSIIQKLQGQLDELVRQMVEIPFWENSNISLDEFAGKIELFDWYRWLGYITLLLFDVLICLLVLFGLIRNSKGTLIAVCLFGVVALVISWVSLGLEFAVSATTSDFCASPDTYVTEVTKQYQVINKETLQYYLSCSLEQSNPFQQRLSGSHKALVEMQDDVFELLRSATREYIQTKGRLEEIQRILNTTEISLHQLTALVDCRSLHMDYVQAMTGLCYDGLEGLIYLVLFSFVTALMFSSIVCSVPHTWRGKRSEEDSEDESLSHGGRQNHDNLYRVHMPSLYSCGSSYGSETSIPAAAHTVSNAPVTEYMAQNANFPNSRCENTPLIGRESPPPSYTSSMRAKYLANSRPDPNNTPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6S7</accession>
    <name>A0A3P9D6S7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SSX family member 2 interacting protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6S7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030049"/>
    <dbReference type="Ensembl" id="ENSMZET00005030994.1">
        <property type="protein sequence ID" value="ENSMZEP00005030049.1"/>
        <property type="gene ID" value="ENSMZEG00005022408.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007688"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF2">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="114"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="583" mass="67020" checksum="44A28447C44E0D3A" modified="2019-02-13" version="1">MPESSLVKDGRSSSVEYGASPLRQFSQSSLLLHRNSYMLSTFCTEHNVQQCLSHINQEISSLGLPPVWTESGDSSELNIVAVLNCMYDLIQLQRRGLRTLESMEVEQLKSSSSIDHLQLTITHLKEQLELSKRENTGLLERERQLQLKAKSLQSCLKNEKEEVQKLQNIIASRASQYNHEMKRKEREFNKLKERLNQLLVDKKEKKQAIDVLNNIGRADGKRSLWKTEKTEAKHEGEMYKTLLSDYDARHRELVLENAELRKVLQQIKKDMVSILSSRKPAAKSDKPEHSGVQATSEEEEEEEEVFDSSKESVELYCFHAREKLTNSIRLQWRRLKSHVERLDSQASLVQMVESKNTDAVPQETQEEEMDRLKLEIQQCKDFIQTQQQLLQHQVSSACDEETASLLSNCYMLQEKERLGDEWKTLEEQRKIFERERKNFTEAAIRLSHERKAFEEDRATWLKHQFLNLSPFADSKKTPLLKSKSAFLISAETEAAATVAPEKLIKCPSDTASPTPRCVALASASTTDLCRTLCFIPENSSVQPKTNGEHVEESGTFCGDVFVQHQQWEYSEDHTLSQDKNSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D766</accession>
    <name>A0A3P9D766_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9D766"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030520"/>
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        <property type="protein sequence ID" value="ENSMZEP00005030520.1"/>
        <property type="gene ID" value="ENSMZEG00005022742.1"/>
    </dbReference>
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        <property type="component" value="LG4"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:double-stranded RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:single-stranded RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cytoplasmic pattern recognition receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd12090">
        <property type="entry name" value="MDA5_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF7">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="14"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="362"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="18">
        <location>
            <begin position="544"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="677" mass="77142" checksum="3B80617075F15A8A" modified="2019-02-13" version="1">MADFGLHNYQQEVVERALKGENIIIWLPTGGGKTRAAVYVAKKHLETTPNAKVMVLVNKVHLVDQHYNKEFEPHLGGTFIIKKVSGENKEKDFFGLVVKQSQVVICTAQILYNALINKEEARHVELSDITLLIIDECHHTHKEEAYNKVMRLYVEKKLKGEKPLPQILGLTASPGTGGAKALEKAVEHVLEICANLDSVIVSAKEYASELKEVVPKPRKSFKIVKERLKDPFRDHLISMMNSIHSHMNLPPDFRLKECGTQEYEADVVNLEHRGIQEKNRLLAQCALHLRQYNDALLINDTLRMIDAYRSLEEYYSKKRTNPIDGTDTFLLELFEENQVELKNLAMDSRFDNPKMDELQSTLLQQFGSGVPSRAIIFSKTRKSTHCLKDWVLKNRALQEAGIKADIFIGAGNGNTYMTQNGQAETIRNFRMGSLNLLISTSVAEEGLDIPECNLVVRYGLLTNEIAQQQASGRARAENSQYAVVAQAGGREDRRERINEYLEELTGQAIDRVQTMTPQDFCTKITQLQEMVVTCTKIEQRRQAKKRSRNTASSIQLLCRSCFTPVASGSDIKLVENMYVNVNPDFKKHYTFGDQLTLKRSFEDWEPGCTIGCKICSEKWGFEIKYKKCAILPNLAIKNFVLESPGQERLPVKKWKDVPFTVEEFNFKEYCQEHFLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D818</accession>
    <name>A0A3P9D818_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D818"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030509"/>
    <dbReference type="Ensembl" id="ENSMZET00005031470.1">
        <property type="protein sequence ID" value="ENSMZEP00005030509.1"/>
        <property type="gene ID" value="ENSMZEG00005022728.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051287">
        <property type="entry name" value="TCR_variable_region"/>
    </dbReference>
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        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19367">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
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        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="275" mass="30521" checksum="34A0BA60D65407BC" modified="2019-02-13" version="1">VERVLCGLLSSLESLDCQQLTASKTEESSLEGSTATLSYRYSRQATGSDQFYWYRQYPGKPPEFLTFNLGTQNTTNSKLSVRMVDDRNGLNLQISSAAVTDSAVYYCAVRPTVTGNSKTLYKNLWTVTANFSSYNNVTSLLLSLVITVFSSGEACHAAAEQQSWKKHSRGNIPVSNQTLIFLRFVCSQNIKNILIDDFKFLISHFGTGDRISDPVPGIMFNVSGDKTLMTLQISSAAVTDSAVYYCAVRPTVTGNSKTLYKNLWSKDNRILHNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D8J2</accession>
    <name>A0A3P9D8J2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">COMM domain containing 7</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
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            <end position="199"/>
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    <sequence length="199" mass="22777" checksum="748A98DAF39726F2" modified="2019-02-13" version="1">MQLHFTKDVLPDSVGTDFQNLNKLNEQQFHHLIEILFQFLLEPKETERFMQQLTEFAGEHGMSAGPLRNLMKSVLLVPQGALKKNLTGEQIKEDLLTLGLSEEKSAHFSLQWAEHYAALTRLAVGQTLMVNQLVDMEWKFGVTVGTSEIQKLGTVFLQLKLVVRKGNSTENVYMELTLPQFYNFLHEMERAKASMECFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DEW5</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Haplochromini</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
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                <person name="Haerty W."/>
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                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
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                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
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        <subcellularLocation>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Olfactomedin-like" evidence="11">
        <location>
            <begin position="180"/>
            <end position="432"/>
        </location>
    </feature>
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            <end position="96"/>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DF78</accession>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
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                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
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                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
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                <person name="Ribeiro F.J."/>
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                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
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                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sulfotransferase 1 family.</text>
    </comment>
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    <dbReference type="Ensembl" id="ENSMZET00005034474.1">
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        <property type="gene ID" value="ENSMZEG00005024885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106676355"/>
    <dbReference type="KEGG" id="mze:106676355"/>
    <dbReference type="GeneTree" id="ENSGT00940000163342"/>
    <dbReference type="Proteomes" id="UP000265160">
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="7">
        <location>
            <begin position="66"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="324" mass="38335" checksum="EE3D52EB40976A63" modified="2019-02-13" version="1">MLCNQKRRRIFLTTPKARQKPTMNISLSAEKAILFSRPELFDFHGVSMTHYFTDNWENVQNFQVRPDDILIATYPKAGTTWVSQILDLLYFGQTCAERQKTIPIYERVPFLEIAIPSLDSGKDLADKLPTTPRLIKTHFPVQFVPKSFWEQNCRIVYVARNAKDNMVSYFHFDRMNVVEPEAGEWNNYFQRFLEGQMVFGSWYDHVNGWWKKKQTYSNIHYMFYEDMIEDTEREIDKLCSFLGLSRSPEEKKMISGGVQFDNMKKNEMANYSTAPVMDFKISPFMRKGKVGDWKNHFTVAQNEVFDEDYKKKMKDPTLQFRTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFG5</accession>
    <name>A0A3P9DFG5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004565082.1">
        <property type="nucleotide sequence ID" value="XM_004565025.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFG5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033124"/>
    <dbReference type="Ensembl" id="ENSMZET00005034227.1">
        <property type="protein sequence ID" value="ENSMZEP00005033124.1"/>
        <property type="gene ID" value="ENSMZEG00005024708.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471225"/>
    <dbReference type="KEGG" id="mze:101471225"/>
    <dbReference type="GeneTree" id="ENSGT00390000013063"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000005">
        <property type="entry name" value="Presenilins-associated rhomboid-like protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF29">
        <property type="entry name" value="PRESENILINS-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="14">
        <location>
            <begin position="200"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="379" mass="42083" checksum="8E680E6139882E3D" modified="2019-02-13" version="1">MAWRSCSVLLRLTGDEGLRSSVRGGRWPQSFQQRCGFRKAARKPESKKVEEELGPAHSESSEAAAQRRTPAPHWDHQAPPSPPRAFGRLVRPLVFTIGFTGCSFGSAAIWQYESLKSRVQSYFDELRADWLEKVRPQKRGDIRKEINQWWNSLSEGQRTVTGIIAANAIVFCCWRVPSLQRFMIRYFTANPASRTLCSPMILSAFSHFSFFHMAANMYVLWSFSTSAVSMLGREQFMAVYLSAGVISTFVSYVCKMATGRFGPSLGASGAIMTVLAAVCTKIPEAKLAIIFLPMFTFTAGNALKAIVAMDTAGLVLGWRFFDHAAHLGGAMFGIWYVLFGHELIWKNREPFVKLWHDFRTRRGPGGGEGGGGGDRGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGA0</accession>
    <name>A0A3P9DGA0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SPT6 homolog, histone chaperone and transcription elongation factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005033192"/>
    <dbReference type="Ensembl" id="ENSMZET00005034315.1">
        <property type="protein sequence ID" value="ENSMZEP00005033192.1"/>
        <property type="gene ID" value="ENSMZEG00005024774.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047446"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035050">
        <property type="term" value="P:embryonic heart tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071599">
        <property type="term" value="P:otic vesicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="1085"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="9">
        <location>
            <begin position="1183"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1476"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1448"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1480"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1508"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1543"/>
            <end position="1553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1588" mass="181883" checksum="BF245C0E7FE8421D" modified="2025-10-08" version="2">MDDDEDDDEKDLIADEIFYPDGEGELEEGEAVDEPMQQPDDDEEGEDEESDIDDFIVDDDGQPITKKRGKKFSGYTDAALQEAQEIFGGDFDFADFDADAYDQGEEEEEDQDEEGWDRPKKQTKRRLGRKSIFEIYEPSELESSHMTDQDNEIRSTDMPERFQLRAIPVKPAEDDELEEEAEWIFRHGFSTLTISMQESTDYLDRGTTTNFSRKGPSTIAKIKEALNFMRNQQFEVPFIAFYRKEYVEPELNINDLWKVWQWDEKWTQLKTRKQNLTRLFQKMQSYQFEQISADPDKPLADGIRPLDTTDMERLKDVQTLEELGDVYNHFLLYYGRDIPKMQNAAKANKKRLKKIKEEELEVEEEEEQKGPDLKLASRRDMYSICQSVGLDGLAKKFGLTPEQFGENLRDSYQRHETEQFPAEPVELAKDYVCSQFSTPEAVLEGTRYMVAMQIAREPLVRHVLRQTFQERAKVNIKPTKKGKKEVDEAHFAYSFKYLKNKPVKELNGDQFLKMCLAEDEGLLTIDICIDLIGVKGYAGDQTYFDEIKQFYYRDEFSHQVQEWNRQRTLAIERALNQFLYPQMAKELKSKLIAEAKESIIRSCCRRLYNWLKVAPYRPDQQVEEDDDLMDENQGKGIRVLGVAYAPSRDTPVFCALINGEGEVMDFLRLPYFMKRRNAFREDEREKKASDIENLKRFLSGKKPHVVAVAGENRDAQMIMEDIKRTIGELEQESSLPAVGVELVDNELATLYMNSKKSEADFRDYPPLLRQAVSIARKIQDPLVEYAQVCSTDEDILCLKLHPLQEHVVKEDLLDALYCEFINRVNEVGVDVNRAIAHPHTQSLVQYVCGLGPRKGSHLLKILKQNNTRLENRTQLVTMCHMGPKVFINCAGFIKIDTASLGDSTDSYIEVLDGSRVHPETYEWARKMAVDALEYDESAEDANPAGALEEILENPERLKDLDLDAFAEELERQGYGNKGITLYDIRAELSCRYKDLRVAYRVPNTEEVFNMLTKETPETFYIGKLITSVVTGIAHRRPQGESYDQAIRNDATGLWQCPFCQQDNFPELSEVWNHFDSGSCPGQAIGVRSRLDNGVQGFIPTKFLSDKVVKHPEERVKVGMTVHCRIMKIDIEKFSVDLTCRTSDLMDKANEWKLPKDSYYDFDTESEDQKLEEEFKKKQQRTPYIKRVIAHPNFHNISFNQAEKMMETLDQGDLIIRPSSKGENHLTVTWKVADGIYQHVDVREEGKENAFSLGHTLWINNEEFEDLDEITARYIQPMASFARDMLGHKYFQECNRGSREKMEELLMRTKREKPTFIPYFISACKDLPGKFILGYQPRAKPRIEYVTITPDGFRYRSQIFPTVNGLFRWFKDHFQDPVPGITPSNSSRTRTPASLNATPANINIADLTRAVNALPRNMTSQMFNAIAAVTGQGQNPNTTPAQWGSSQYGYGGSTGGGGSSSAYHVFATPQQPMATPMMTPSYSYTTPSQQALGTPQYPGSTPHSHHGHSSGTPSSSTSSRGRTPQQPSSSSSTAVDWGKMAEQWLKEKEAEGRKKSQRMTPRPSPSPMIESTPMSITGDATPLLDEMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DGR8</accession>
    <name>A0A3P9DGR8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Exosome complex component RRP41</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Exosome component 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ribosomal RNA-processing protein 41</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC2, EXOSC7 and EXOSC9. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with DDX60. Interacts with DIS3; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004542820.1">
        <property type="nucleotide sequence ID" value="XM_004542763.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DGR8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033584"/>
    <dbReference type="Ensembl" id="ENSMZET00005034733.1">
        <property type="protein sequence ID" value="ENSMZEP00005033584.1"/>
        <property type="gene ID" value="ENSMZEG00005025086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480542"/>
    <dbReference type="KEGG" id="mze:101480542"/>
    <dbReference type="CTD" id="54512"/>
    <dbReference type="GeneTree" id="ENSGT00940000153348"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000010">
        <property type="entry name" value="Exosome complex component RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="15">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="16">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="245" mass="26823" checksum="D8EDC7728ADB5750" modified="2019-02-13" version="1">MAGLELLSDQGYRLDGRKATELRKLQARMGVFTQADGSAYLEQGNTKALAVVYGPHEMRGSRSRTLHDRAVINCQYSMATFSTAERKRRPHGDRKSTEMSLHLKQTFEAAVMTQLYPRSQIDIYVKILQSDGGNYSVCVNAATLAVIDAGIPMRDYVCACTVGFVDETPLADLCYAEENGGVSSLALALLPRGGQIALLQMDARLHQDHLETLIEAAMTACKGVSKVLDEVVRQHLQEASVLTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DHS0</accession>
    <name>A0A3P9DHS0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="14">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="14"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DHS0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033929"/>
    <dbReference type="Ensembl" id="ENSMZET00005035125.1">
        <property type="protein sequence ID" value="ENSMZEP00005033929.1"/>
        <property type="gene ID" value="ENSMZEG00005025371.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157527"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14055">
        <property type="entry name" value="STKc_TGFbR2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000260">
        <property type="entry name" value="TGF-beta receptor type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000213">
        <property type="entry name" value="TGF-beta receptor type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF55">
        <property type="entry name" value="TGF-BETA RECEPTOR TYPE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018274472" description="Serine/threonine-protein kinase receptor" evidence="15">
        <location>
            <begin position="21"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="288"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="627" mass="69128" checksum="4666664DA69CA121" modified="2019-02-13" version="1">MCVCVCVCVCECVCVSVCVCVCVCVCVCVCVCGVCVVWCVCVCVCLCVWCVCVSVCVVCVVCVVCVCVCGVCLCVCLCVCVCVCVCVWCVCGVCGVVCVCVCVCVCVSVCVVCVWCVWCGVCVCVCECVSVCVVCVCVSVCVWCVCVCVCVCACVCVCVCVVCVCVCGVCLTHLMLTLFSCFSSSSPAVDPTPDPLESNHSLISAVLVSMLPLLVMVIAFFGMFYWCRIHRQRRPNRQWESSFNFKRKPIAGGLDCSDACAIMTDDDKSDSSSTHANSLNHNTEPLPIELDLLVGKGRFAQVYKAKLKQTTWNQFETVAVKIFPYEEYASWKNEKDIFSNTDLRHENILHFLTAEERKVEKQYWLITAFHPKGNLQEYLTHHVISWQELQVFSSSLARGVAHLHSDRLPCGSPKVPIVHRDLKSSNILVKNDGTCCVCDFGLGLCLDSSLSVDELANSGQVGTARYMAPEVLEARLNLENIESFKQTDIYSMALVLWEMTSRCEAIGGHKGYEPAYGSKVREHPCVESMKDNVLRDRGRPEIPDMMCATIKECWDHDPEARLTAHCIAERISELEDEMGKLSSRSSSAEKIVEELKIPVEVEIPEEEVKITEIQNIIAVDCSISDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIU0</accession>
    <name>A0A3P9DIU0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIU0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034269"/>
    <dbReference type="Ensembl" id="ENSMZET00005035473.1">
        <property type="protein sequence ID" value="ENSMZEP00005034269.1"/>
        <property type="gene ID" value="ENSMZEG00005025613.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163251"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="96"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="551" mass="62066" checksum="699D148D7EC41476" modified="2019-02-13" version="1">MSNGNIRDFDEITSFLGDYGLFQILVMVLLSVSTMPAGYMGVIVVFVSDTPEHYCRSPNSSSRNGTEWEQENGFHDRGSWMGPGSCSRYKLNENWTEKAAGFNDTEQCLDGWVFSTDKYTTTIVSEWDLVCDNAWKVPFSTSFFFVGALIGSFISGHLSDRFGRKPVFFFTMILQTVTALIQVTSVSWVMFTILNCLRGLGQISNFIASLVLGSEMLSKSARVTYILLGHSLGFGFGYALLPLFAYFIRGWRMLLVAAALPGFLFIPTWCLIPESPRWLLQKGRVEEAELVIRKAAQWNRVPAPEVIFRAGDCLELMQNKDEEEQTYTYMDLMRTHNIRNITILGVFIWISVAMVYYGLSLNSSNLHGNIYLNCFISAAIDIVVYVATWLLIDRAPRPTLLFTTTLFKLFLITAFFFPDMPIMVQVLALVGKTGVSAAYCFIYVFFTELMPTVVRNMGLGICATAARIGAIICPYLLYMGLYSKILPYIIFGTASIMAAAVSMLLPDTRNSKLPDLLIQTKHIRRYAVDGRTEFRFPFYFNGVMFVDGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DIZ0</accession>
    <name>A0A3P9DIZ0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DIZ0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005034116"/>
    <dbReference type="Ensembl" id="ENSMZET00005035314.1">
        <property type="protein sequence ID" value="ENSMZEP00005034116.1"/>
        <property type="gene ID" value="ENSMZEG00005025498.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000287233"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005034116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="366" mass="34361" checksum="A30AA8CF72D0CB03" modified="2019-02-13" version="1">MTIPPLKGWLPTAQNRETKQKQKNPTQGGRRGTRTEGPEQEAKQTTEHTGAQDQSQNKVQGADPEPTGTRVPGSHGRGADQAGGTGDRAGPEAGRAEGSGGGEGDDGAVQEAGRAEGSGGGEGDDGAVQEAGRAEGSGGGEGDDGTLRLGQTRTKTLRLGQTKHRPELRQARLKARRPDQARSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAGPGEGSEAAAADEGSGAAADEGSGAAADEGSDGAAAGEAQAGAGVAEAAAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DMN9</accession>
    <name>A0A3P9DMN9_9CICH</name>
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        <submittedName>
            <fullName evidence="13">ArfGAP with GTPase domain, ankyrin repeat and PH domain 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centaurin gamma-like family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560309.1">
        <property type="nucleotide sequence ID" value="XM_004560252.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DMN9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035699"/>
    <dbReference type="Ensembl" id="ENSMZET00005036962.1">
        <property type="protein sequence ID" value="ENSMZEP00005035699.1"/>
        <property type="gene ID" value="ENSMZEG00005026665.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466069"/>
    <dbReference type="KEGG" id="mze:101466069"/>
    <dbReference type="CTD" id="116986"/>
    <dbReference type="GeneTree" id="ENSGT00940000158956"/>
    <dbReference type="OrthoDB" id="6136903at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08836">
        <property type="entry name" value="ArfGap_AGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04103">
        <property type="entry name" value="Centaurin_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000001">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000109">
        <property type="entry name" value="Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000545">
        <property type="entry name" value="arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000298">
        <property type="entry name" value="ArfGAP with GTPase domain, ankyrin repeat and PH domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051282">
        <property type="entry name" value="Arf-GAP_GTPase_ANK_PH"/>
    </dbReference>
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        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
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        <property type="entry name" value="ArfGAP_dom"/>
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        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
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    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
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    </dbReference>
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        <property type="entry name" value="CENTAURIN-GAMMA-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="650"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="12">
        <location>
            <begin position="917"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="556"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="711"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="764"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1147"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="642"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1157"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005430"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1172" mass="125783" checksum="B49CAF53F8233DEC" modified="2019-02-13" version="1">MSGGGALQQRTTYLISLTLVKVEAVEENGDEAKNSNQGKEVEARPGDERVEAEGGASTRTENGAGVVLGEPQRAEDAVIVKGGTDELKEGERRSLSPLTDKLPSNVPSKVAEKPPCNLSIPLPAERVTIQKTKSADVVEKPFSSPEAKQCRSPSLTTTPPMEVAEPSRTPTRTSLPIRPAGQRPVSLLKSHSSVATRGRDSREGRERSPTSAQSLDRKDCRVTTRSPGPCRASWAEASRTEGWRDLQDEAQTGIQLEIGGGMAAVMRDIPRKDRLKSGSTSLPAPPTQAPKPARKGKSRTLDNSDLNSLSEDLGLAREAQQGQQGQRGSAKDRKMLKFISGIFTKSSSGAAGSSSTAPPVYIQRDSSEEEVNIANSQEWTLSRSIPELRLGVLGSLKSGKSALVNKYITGSYSAVEKPDGGRYKKEVLVDGQSHLLLIREEAGPPDAQFSSWADAVILVFSLENEASFQELYQLYSQLSAFRSDIPVIVVGTQDKISSTNPRVIEDQRARQLCIDVRHSLFYETCATYGFNVDRVFSEAAQKIVAQKKQAALQACKSLPNSPSHSGGSTPGSASFPGQASNGPSIGYAYSLPSTPVVSHRELRVAQGDGGGSVNARSLKSIPRRPSLFKNRDTDKKGGDAKGDLSSLRGVPIKQGILWKRSGSSLNKEWKKKYVTLSNNGTLSYHSSSSDYTQNTHGKEIDLLRVTVKVPGKRPPRAVAPTGPSPAPPGAVPGVNGLSKELPAADSTSTVPQLCPATLSVVADDRSGGLSPQGGERGLQRCPSSLSTKAQSVDALEATAGSFGGKDPSQSSPMSDRKKNRRKKSMNQKGDAAVGQAEAKRKMWKLKSFGSLRNINKTEEENADFIIVSFTGQTWHFEAPSMDERDSWVTAIESQILASLGSCESGRNKARRSSQSEAVALQAIRNAKGNSQCVDCEAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPGELTQVLAAIGNHMANSIWESCTQGRTKPTPSATREERESWIRAKYEQRAFVAPLVPASGAQLPEDGVPVWLLSAVTDRDLPRLLLLLAHSTKEQINAPPAGSPSLPRTALHAACQLGDVVMTQLLIWYGIDVKAKDNQGQTAMMLATKKGSKSCIDILLQHGCPNETSPTAATPILSRRSSTASLGRTSSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DN93</accession>
    <name>A0A3P9DN93_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Snail family zinc finger 1b</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546016.1">
        <property type="nucleotide sequence ID" value="XM_004545959.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DN93"/>
    <dbReference type="Ensembl" id="ENSMZET00005036859.1">
        <property type="protein sequence ID" value="ENSMZEP00005035601.1"/>
        <property type="gene ID" value="ENSMZEG00005026596.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467971"/>
    <dbReference type="KEGG" id="mze:101467971"/>
    <dbReference type="CTD" id="792194"/>
    <dbReference type="GeneTree" id="ENSGT00940000154681"/>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003261">
        <property type="term" value="P:cardiac muscle progenitor cell migration to the midline involved in heart field formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042074">
        <property type="term" value="P:cell migration involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008078">
        <property type="term" value="P:mesodermal cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022408">
        <property type="term" value="P:negative regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048920">
        <property type="term" value="P:posterior lateral line neuromast primordium migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000693">
        <property type="entry name" value="Snail family zinc finger 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000942">
        <property type="entry name" value="Snail zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF37">
        <property type="entry name" value="ZINC FINGER PROTEIN SNAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="266" mass="29553" checksum="35689703BFF131CE" modified="2019-02-13" version="1">MPRSFLVKKYFPYKKQHNRESYPESHTAFVPENFPLAELPSENSSALTCQPATLIFSVDILPRPHPLISPESLPPSPMGPLDLSSSPSCSSGEEEEDGGRTSDPPSPDTIQPIYHCLHCTKSYTSLSAFSQHQMSHQLPPCAPETPMTTEASARPVFHCKHCPKEYNSLGALKMHIRSHTLPCVCTTCGKAFSRPWLLRGHIRTHTGERPFACQHCSRAFADRSNLRAHMQTHSEVKKYQCGSCSRTFSRMSLLNKHSASGCCPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DNW8</accession>
    <name>A0A3P9DNW8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sp5 transcription factor-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004558816.1">
        <property type="nucleotide sequence ID" value="XM_004558759.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNW8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036465"/>
    <dbReference type="Ensembl" id="ENSMZET00005037746.1">
        <property type="protein sequence ID" value="ENSMZEP00005036465.1"/>
        <property type="gene ID" value="ENSMZEG00005027215.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484343"/>
    <dbReference type="KEGG" id="mze:101484343"/>
    <dbReference type="CTD" id="324261"/>
    <dbReference type="GeneTree" id="ENSGT00940000166618"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035118">
        <property type="term" value="P:embryonic pectoral fin morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030902">
        <property type="term" value="P:hindbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030903">
        <property type="term" value="P:notochord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032474">
        <property type="term" value="P:otolith morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036342">
        <property type="term" value="P:post-anal tail morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF28">
        <property type="entry name" value="SP5 TRANSCRIPTION FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="364" mass="40844" checksum="C1858A3FC96DC1AF" modified="2019-02-13" version="1">MAALTIQRTDNFLHTFLQDRTPSSSPEGAPNALSFLATTCSQAWQVGSTMGSEGSQFPYEGTVSSTSGMFQLWSNDMPPSTALSTHQMTFTVPKMQFPGHMQSGLGHHHHHHHPHHHHHELPLTPPAEPPSSYSFELSPVKVLSSQPQTNSHYYPQHNNVGQNFPSFLPNSSGRHHLSGGHVEEGQQWWSLPQTNATPSNHPFSLGRQLVLGHQPQIAALLQGTSKGLLSSTRRCRRCKCPNCQANGGGLEFGKKRLHICHIPECGKVYKKTSHLKAHLRWHAGERPFICNWLFCGKSFTRSDELQRHLRTHTGEKRFGCQQCGKRFMRSDHLSKHVKTHQTRKSRSGQPSQSTDPLLTNIKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPP4</accession>
    <name>A0A3P9DPP4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Rac GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Male germ cell RacGap</fullName>
        </alternativeName>
    </protein>
    <organism evidence="36 37">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Secretory vesicle</location>
            <location evidence="4">Acrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004545240.1">
        <property type="nucleotide sequence ID" value="XM_004545183.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012772914.1">
        <property type="nucleotide sequence ID" value="XM_012917460.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012772915.1">
        <property type="nucleotide sequence ID" value="XM_012917461.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DPP4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036106"/>
    <dbReference type="Ensembl" id="ENSMZET00005037380.1">
        <property type="protein sequence ID" value="ENSMZEP00005036106.1"/>
        <property type="gene ID" value="ENSMZEG00005026943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476502"/>
    <dbReference type="KEGG" id="mze:101476502"/>
    <dbReference type="GeneTree" id="ENSGT00940000154610"/>
    <dbReference type="OrthoDB" id="2218807at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04382">
        <property type="entry name" value="RhoGAP_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000034">
        <property type="entry name" value="Rac GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000033">
        <property type="entry name" value="Rac GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF5">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="21" id="KW-0007">Acetylation</keyword>
    <keyword evidence="28" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22 32" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="29" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="26" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="17" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="23" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="24" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="25" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="34">
        <location>
            <begin position="297"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="35">
        <location>
            <begin position="360"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="32">
        <location>
            <begin position="58"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="33">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00067896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00075869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="634" mass="70861" checksum="028258F282AB4472" modified="2019-02-13" version="1">MELSALNLYNQFESLRAQVDGLNESIEPQFLQMAVNFEDCRKKWLQAGEELVSSKEMLAKAETERGALEVKLKHARNQVDVEIRRRQKAEAVYEKLERQLQLIRELLVSENNGGSVLLSEEQRSALAFLSAHSQAAQAANSNLNSSRRLTTIDESASLVSDISYDHTDDSLDWDSSVMKNVRLRRRQKRRSSRKPSEGHLQAVKKPRSTGCPSDRMNESIVAKTTITVPVNGGAVEAVSTIETVPYWTRSRKKSVAPSWIDTPTTDNSETVSEAPRTPVSEFPAQLQTPKTNEGGKKHHFISKTVIRSEFCVSCGRRTKFGKLYLRCQDCRAVAHPECRDLCPMPCNPTALNTPVKNTESTLADFAPLTAPMIPALVIYCIKEIEKRGLHEVGLYRVSGHERVVKELKEKLIRGKTLPPLNKVEDINVIAGVLKDFLRNLPEPLLTFHLNKAFMEAAEIQDDDNSLAMLYQTMSELPQPNRDTLACVMIHLQKVSRSVDTKMDVNNLARVFGPTLVGHAVPNPDPMTILHDTNRQPRVIERLLSIPDSYWSQFAYPDNASIDNAHNTDTPNHKVSILGPVTTPEHQMMAKTPSSSSLSQRMKHTLSSTTLFGSKSKATSACNRQGSFFASPQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ31</accession>
    <name>A0A3P9DQ31_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plakophilin 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ31"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036383"/>
    <dbReference type="Ensembl" id="ENSMZET00005037661.1">
        <property type="protein sequence ID" value="ENSMZEP00005036383.1"/>
        <property type="gene ID" value="ENSMZEG00005027151.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156735"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF3">
        <property type="entry name" value="PLAKOPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="704" mass="75884" checksum="7DC34748483B0ADF" modified="2019-02-13" version="1">MMAPEPLRSATTIRVAEDTSLALPSDNKLRSGQQRVLDQVHSIKRSKSKHGKSVRAPSPTSPPLPSFTKQTDFASFRYSPSKANGTFRSKSTMSAGTTKETSRTLSTRNSGGRYMSTSGVWEENISASTWPKTPNGIKPSKSDPALATPFSPATGPGMRIKGQMAQGQSTFQTRTNRHSVSSVTNGNAITSSQSRIVRMPSTQSQHEGKMGTIKMESKSMMNIPDLTLKEAVEFLGSSEESYQQWGATFIQHTTYTDESAKSEVFQLGGIPTLVALLRSGNPQVCQVAAGALRNLVFKNQNNKLEVQRCGGIAKALQLLKETDSTETQKQITGLLWNLSSANELKEELAATALPALTQCVVVPYTSLSDSGPSSYIDPSVFNSATGCLRNLSSGRGGQRQAMRSCPGLIDSLMSYMKSCVAEQNPNDSSLENCACILHNLSYKLEQESPVSFINYNPSRDAQHEKSPTIGCFSPKSSKAQKTFSFDTVDRVLSPPSGVKWLSHPKAIDTYLSLLESSENKATLEACCGALQNLTASKGNGSDAVSQILVSKSRDLSQFGPLLKPSNPKLQNTALSLLGNMSRTDSLQGTMAKQILPQLVELLQGGPSQLGNSDESVAAACNTVLRLMSANSDTSKKVINNAVIQSLFDLSEDKKLTKGSSAASLLLYSIWQDKNLQSSMKKMGLTKSAFINDNITHVVSQLEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DQ62</accession>
    <name>A0A3P9DQ62_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">MFSD2 lysolipid transporter A, lysophospholipid</fullName>
        </submittedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:43860"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:73873"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:43856"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = 1-hexadecanoyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:43864"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1-acyl-sn-glycero-3-phosphocholine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphocholine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:44376"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1-acyl-sn-glycero-3-phosphoethanolamine(in) + Na(+)(in) = a 1-acyl-sn-glycero-3-phosphoethanolamine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:43868"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:64381"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004540892.1">
        <property type="nucleotide sequence ID" value="XM_004540835.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DQ62"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036271"/>
    <dbReference type="Ensembl" id="ENSMZET00005037545.1">
        <property type="protein sequence ID" value="ENSMZEP00005036271.1"/>
        <property type="gene ID" value="ENSMZEG00005027056.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101481882"/>
    <dbReference type="KEGG" id="mze:101481882"/>
    <dbReference type="GeneTree" id="ENSGT00390000005318"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015245">
        <property type="term" value="F:fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051978">
        <property type="term" value="F:lysophospholipid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990379">
        <property type="term" value="P:lipid transport across blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140329">
        <property type="term" value="P:lysophospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000185">
        <property type="entry name" value="sodium-dependent lysophosphatidylcholine symporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000183">
        <property type="entry name" value="sodium-dependent lysophosphatidylcholine symporter 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF29">
        <property type="entry name" value="SODIUM-DEPENDENT LYSOPHOSPHATIDYLCHOLINE SYMPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="519" mass="57517" checksum="AFB462AC4517460B" modified="2019-02-13" version="1">MARGEGAEQYAATLLSVKPLNAEIKTVKLKTQRNRLSVFSKVCYAFGGAPYQITGTVLGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFLVSRSRSTRFGRMMPWIIFSTPFAVLTYLLIWYVPPFEEGKVIWYLVFYCLFQSMQTCFHVPYSALTMFISRDQKERDSATAYRMMVEVLGTVLGTAIQGQIVGGNSNCPTESDAPYSTNSSSVNTTIASLDQTKQAYLVASGVICIIYVLCAAILFLGVKEQKETGRDKSEPLTFAQGLRLVMCHGPYVKLVIGFLFTSLAFMLLEGNFALFITYALGHRKDFQNILLVIMLSGSLTIPWWQWFLTRFGKKKAAYFGISWAVPFMILIVSVKSNLIVSYLVSVAAGVSVAAAFLLPWSMLPDVVDDFKVQNPDIRGHEALFYSFYVFFIKFASGVSLGISTLSLKFAGYVTGGCSQPEAVSVTLKVLVSPVPVVLIAVGLLILKTYPIDEERRQGNRKLLQAMFDSETDSESETSDRGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRC5</accession>
    <name>A0A3P9DRC5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pleckstrin</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_012774742.1">
        <property type="nucleotide sequence ID" value="XM_012919288.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774743.1">
        <property type="nucleotide sequence ID" value="XM_012919289.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774745.1">
        <property type="nucleotide sequence ID" value="XM_012919291.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_023009214.1">
        <property type="nucleotide sequence ID" value="XM_023153446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRC5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005036999"/>
    <dbReference type="Ensembl" id="ENSMZET00005038291.1">
        <property type="protein sequence ID" value="ENSMZEP00005036999.1"/>
        <property type="gene ID" value="ENSMZEG00005027577.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101468682"/>
    <dbReference type="KEGG" id="mze:101468682"/>
    <dbReference type="CTD" id="5341"/>
    <dbReference type="GeneTree" id="ENSGT00940000157885"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13301">
        <property type="entry name" value="PH1_Pleckstrin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13302">
        <property type="entry name" value="PH2_Pleckstrin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000269">
        <property type="entry name" value="Pleckstrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000226">
        <property type="entry name" value="Pleckstrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF1">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="136"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="244"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005036999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="351" mass="40103" checksum="3B768F8EFF096E5B" modified="2019-02-13" version="1">MEPQEIREGYLVKKGTLLNSWSAVWVVLSEDGVDFYKKKTDRSPKGMIPLKGATLSSPCQDFVKRMLVFKITTEKKQDHFFQASYVEERELWVKDIKRAITCIQGGKKFARKSTRRSIRLPETVNLAALYTEMKNQDEGVKELKLEQENRVFNHCFTGATVIDWLISKEKARNRPEALMLATGLMNEGFLQPAGDLSKEGAESGEQAAFLDETKALYYFADSGFFCEGYSSDEDVLLKEEFRGNIIKQGCLVKQGHRRKNWKVRKFILRDDPAYIHYYDPAKADDPLGSIHLRGAVVTAVDYVPDAKKKDIDGNLFEIITADETHYFLQAATDQERKEWIKAIQMVSKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DRT1</accession>
    <name>A0A3P9DRT1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="10">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024655573.1">
        <property type="nucleotide sequence ID" value="XM_024799805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DRT1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037154"/>
    <dbReference type="Ensembl" id="ENSMZET00005038453.1">
        <property type="protein sequence ID" value="ENSMZEP00005037154.1"/>
        <property type="gene ID" value="ENSMZEG00005027682.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155114"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF14">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="248" mass="26905" checksum="253357FA806A796A" modified="2019-02-13" version="1">MRGQPLLSPVIYREKMAAAPVMMPYFGQQISSKSDLVPDWTRQEVSTGTTIMAVEYDGGVVIGADSRTTTGAYIANRVTDKLTRIHDKIYCCRSGSAADTQAIAEVVAYQLGFHSIELDEPPLVETAANLFRASCYRYREELTAGILVAGWDKRKGGQVYSVPIGGMLVRQPVSVGGSGSTYIYGFMDANYKPGMNKEQCMEITAAALSLAMERDGSSGGVVRLASISEEGVERRVILGNQLPKFSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSK5</accession>
    <name>A0A3P9DSK5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aspartate aminotransferase</fullName>
            <ecNumber evidence="14">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70223"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:70225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:70295"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="ChEBI" id="CHEBI:140699"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:70297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17441"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57678"/>
            <dbReference type="EC" id="2.6.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:17442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="14"/>
    <dbReference type="RefSeq" id="XP_004555870.1">
        <property type="nucleotide sequence ID" value="XM_004555813.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSK5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037222"/>
    <dbReference type="Ensembl" id="ENSMZET00005038525.1">
        <property type="protein sequence ID" value="ENSMZEP00005037222.1"/>
        <property type="gene ID" value="ENSMZEG00005027741.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464046"/>
    <dbReference type="KEGG" id="mze:101464046"/>
    <dbReference type="CTD" id="2805"/>
    <dbReference type="GeneTree" id="ENSGT00950000183082"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120554">
        <property type="term" value="F:2-aminobutanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047801">
        <property type="term" value="F:L-cysteine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000044">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF38">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="29"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="410" mass="46006" checksum="877E4DE367D9F174" modified="2019-02-13" version="1">MSLFSEVPQAAPVAVFKLTQDFNNDQFPNKVNLGVGAYRTDEGQPWVLPVVKKVEKIIVHDDRLNHEYLPILGLPEFRSSASKIVLGDNSPAIQENRVGAVQCLGGTGALKIGAEFLRRFYNGSNNTKTPIYVSAPTWENHNAVFSSAGFEDVRPYRYWDAEKRGLDLAGFLGDLESCPEHSVFVLHACAHNPTGTDPTQEQWKQIAEVMMRRKLFAFFDSAYQGFASGSLEKDAWAVRYFVSSGFEMFCAQSFSKNFGLYNERVGNLTVVARDADNLKRVLSQMEKIVRITWSNPPSQGARIVTITLTSPELFSEWQENVKTMANRVLLMRSQLKAKLQALGTPGTWDHITNQIGMFSFTGLNPKQVEYLVKEKHIYLMASSRINMCGLTTKNIDYVAESIHEAVTKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DSL7</accession>
    <name>A0A3P9DSL7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adaptor related protein complex 4 subunit epsilon 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9DSL7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005037126"/>
    <dbReference type="Ensembl" id="ENSMZET00005038422.1">
        <property type="protein sequence ID" value="ENSMZEP00005037126.1"/>
        <property type="gene ID" value="ENSMZEG00005027658.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182838"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="369" mass="41890" checksum="40FF48B8A7FD9F4D" modified="2019-02-13" version="1">MSDVVEKTLTALPSLLSLDSHPGSAKLSSTSKLGNLIRGITELTSKHEEEKLIQHELLAIKEQVSSPNTTMMKELMVRSIYCEMLGYEASFSYIHAIKLAQQGTVLEKRVGYLAVSLFLNESHELLLLLVNTVLKDLQSTNLIEVCMALTVVSQMFPKDMIPAILPLVEEKLNHPKEIIRRKAVLALYKFYLIAPNQVQHIHNKFRKALCDKDPGVMTASLHIYLQMIQENPEAYKDLTPSFVTILKQVVGGKLPMDFNYHTVPAPWLQIQLLRILSLLGKNDQSTSEVMYEVLDESLQRAEMNHNITYAILYECVKCIYTIHPKSNLLEKAAKCIGNFVLSPKINLKYLGKRQRETRLYINNVSLLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DTV8</accession>
    <name>A0A3P9DTV8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9DTV8"/>
    <dbReference type="Ensembl" id="ENSMZET00005039296.1">
        <property type="protein sequence ID" value="ENSMZEP00005037899.1"/>
        <property type="gene ID" value="ENSMZEG00005028322.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163716"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF779">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="74"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="294" mass="33592" checksum="4186F6485CDC90C0" modified="2019-02-13" version="1">SKSYPAVTELVFKMIMSTVNILSYAEIPSTDEDIPRELSVGQLLERANRNYTPDIDEPTLIGGDVAIKSEADRNADPCTSRGCMWGKWTDGKVYVPYYIANHYSSREIAIITRGLESFSSVSCIRFRPYQDGDHEWLSIESRNGCYSYVGRQGGGQTVSLSRQGCLYHSTVQHELLHALGFNHEQTRSDRDNYIRVYWENILDDMVYNFYKIDTLNQGTPYDYNSVMQYERYAFSKNNQPTMVPIPNSNVMLGGATQMSKNDIDRLNRLYQCCKYTATTNTQSDTVLQSQLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DU05</accession>
    <name>A0A3P9DU05_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin/ISG15 ligase TRIM25-like</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DU05"/>
    <dbReference type="Ensembl" id="ENSMZET00005039353.1">
        <property type="protein sequence ID" value="ENSMZEP00005037954.1"/>
        <property type="gene ID" value="ENSMZEG00005028381.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286922"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005037954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34008" checksum="02AF51CACB9F56BE" modified="2019-02-13" version="1">MAQKGVQLDRETFSCSICLDLLKDPVTTACGHSYCMNCIKSFWDEEDRKGIHSCPQCRKTFTPRPVLEKNVMFAALVEQLKKTGFQAAPADHCYAGPEDVACDVCTGRKLKAIKSCLVCLISYCEKHLQPHYDVVQFQKHKLVAPSKKLQENICSRHDEVMKIFCRTDQQSICYLCLMDEHKGHETVPAAAERTEKQKELEVRRLNIQQRIQEREKDVKLLQQEVEAINGSADKAMDFLSMHAGVFKPRQEHLLHLLLRMSEGRVPANTYGSDVTNISLNSKSVFPTTVPQHIQGVQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ARQ2</accession>
    <name>A0A3P9ARQ2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARQ2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000087"/>
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        <property type="protein sequence ID" value="ENSMZEP00005000087.1"/>
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        <property type="component" value="LG4"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="374" mass="42528" checksum="229369A7A511DFEA" modified="2019-02-13" version="1">PLHKRMAQHRRATSTGQDSAPLIKLLFFDASPYLVFIFPHLYRLLGLCNNFAYVVMLSAAHDILEKQESRNETASVREQMYVQLLHFSWQAVLLADILPTLFIKLFAPFVIHKMPYGIRVLFCAIMAATSFLLVSFSSAVWMSILGVIFASISSGLGELSFLSLTVYFSSVLEGWGSGTGAAGLIGALLYSGLIQAGLQAQTVTETYKMICRLLHPNNFTSYFLLLVCPPSLPQWRTKDTEYAALVSEDRQQLLDSSDEEEPESSTTETVCYQSKYTVYLFDLKLFVLPLGVVYLTEYFINQGLMELLFFHNIFLTHAAQYRWYQTLYQLGVLLSRSSLHCVKIRRVWILSVLQVRNENKIQISIRVCSLFLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AT40</accession>
    <name>A0A3P9AT40_9CICH</name>
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        <submittedName>
            <fullName evidence="4">Ras association domain family member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="STRING" id="106582.ENSMZEP00005000572"/>
    <dbReference type="Ensembl" id="ENSMZET00005000643.1">
        <property type="protein sequence ID" value="ENSMZEP00005000572.1"/>
        <property type="gene ID" value="ENSMZEG00005000471.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157502"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF8">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="117"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="3">
        <location>
            <begin position="203"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="255" mass="29662" checksum="58DA5DED6814D473" modified="2025-10-08" version="2">MSGCSLLSLMNLNRNEDCAERMYCFNSPGWFVTYHVAFPFLLCPFSSKDVEKERELRTEFSKEEIWQRIEQYNLLTKDHLKMTLGAGGVYTGFIKVQMDLRRPMTVQGSQTRAGEAFYLPQGVSNTLHVSSKTTVKEVIVGLLSKFTVADNPAKYALYKRYRREEQVYTCKLADAEKPLFLRLVAGPDPDLLSFVLKEQQTGEVMWDAFSIPELKNFLRILEKEEQEQKDAVIRRYETYRQRLQEALLEVRGHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATH0</accession>
    <name>A0A3P9ATH0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Caspase activity and apoptosis inhibitor 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
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            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004554528.1">
        <property type="nucleotide sequence ID" value="XM_004554471.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATH0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000903"/>
    <dbReference type="Ensembl" id="ENSMZET00005000981.1">
        <property type="protein sequence ID" value="ENSMZEP00005000903.1"/>
        <property type="gene ID" value="ENSMZEG00005000801.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467385"/>
    <dbReference type="KEGG" id="mze:101467385"/>
    <dbReference type="CTD" id="79886"/>
    <dbReference type="GeneTree" id="ENSGT00390000017010"/>
    <dbReference type="OrthoDB" id="10064012at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038991">
        <property type="entry name" value="CAAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740:SF3">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15335">
        <property type="entry name" value="CAAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="323" mass="35295" checksum="AFFC8BCCB0616B1F" modified="2019-02-13" version="1">MLKKKSSTSEKKRKHFQSEERHDSGKRRSTGPGLEESKDELADPELDKIGSDIEEGGLDLSLAFQPITAYVGDKRQMLEQCFHVLGEKKLRKMLPDELKECSVEEIKTLCWEQLEPITEKNLIQILAGEEVTAGNDNENSEESLESQQDSIVDSTSCLKETAKSEDPKQEGGGSGEESDVLSINADTYDSDIEGPKEEQTVKEEQTAAVKEGDDDDNSRLCTDPAAKPEPANPEPKKDIQSDIDKSVSEILACSSTPIKDAAKEQSTPLQSPDVSGPVSSGDPAVCKPSIQQLELLELEMRARAIKALMKASNGKTPHVTPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVA6</accession>
    <name>A0A3P9AVA6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Epidermal growth factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVA6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001650"/>
    <dbReference type="Ensembl" id="ENSMZET00005001743.1">
        <property type="protein sequence ID" value="ENSMZEP00005001650.1"/>
        <property type="gene ID" value="ENSMZEG00005001341.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158366"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000036">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF5">
        <property type="entry name" value="PRO-EPIDERMAL GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="501"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="544"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="587"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="631"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="789"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="915"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="953" mass="106072" checksum="A4995FCCCD81F5C0" modified="2019-02-13" version="1">MSLLTPRVKKESLVLGQLHLSDNKCTAIIQYTKSEYVEISLLIITSQQNPRVMTLTPFLIFGHGKAIHRMGLNGKNHRRLVPGVGSSILLDFHFKEQRVYWVDRHTGKLYSYDKHISGLAVDWIWNSVYWTSGEKGEVKRIDINGKKQRTLLRHLTQPNSISVDPSNRFLFWLSGGMSPSIQRSDVTGQMKITLIKITEQLRALSIDRVDKRLFWVQFGPQGESAIASCDYNGNALHTMNLPLQSHSVGISVFLEHIYYTDSESRVIKQVNKYTGGEPHVVNIKQMGKPPVDIKIVHPLNQPTADPLSPFPGYSVCQCSEGFVLSMEGTYCKDVNECAHWNHGCSLGCENIPGSYFCTCPKGYALLPDRKTCQEIIPCERNMTKCGNGCLSTGNGAVCVCPEGSILQEDGQTCTGCSSADRGGCSQLCNPVTPVSWECSCLPGYQLHQDGKHCIATGPPSYLLVANLVDVRRINPDGTVDQILAEEPRGIIVALDYDPVQNNVYFASTSQKTIERVDIKGGPRNILISDGLDSPEGLAVDWVHRKMYWTDKRRSTVDCSTLDGLHRETIVRKGLEKPRGIAVHPLAKKLFWTDIGTHPVVECSSLEGRDRAVIARTNLVSPTGLTIDFTEDRVFWCDQRKGTIETAALDGSDRRVLSKNQVGQPFDLALFEDRLWISDQERHQLTSVHKRTGKTLQWIQGSMVQPASIVVVHPLAKPGADMCLHLKGGCSQVCESKMGFAHCSCFSHYILSADGKTCLTVDASNGTAGDVSCVLFYTVLQLTAPIFVLDIDECNLGIYNCDKNEECQNTAGKYYCKCLAGYYSDGQTCQGDRFLLLTYRIGTFSSCVSGYMGERCQFSDLEWLELQRAEKEKKRNVVITACMVVLVSLLSITACVTYCYGTRKRFHKQPSVDNVSETSMTDESMSETTTTTVPRVRPLLQSSVINTYSFYVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AWK0</accession>
    <name>A0A3P9AWK0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="28">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
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            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:46681"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27 28">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="25">Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MTARC2. Interacts with MTLN; the interaction is required to maintain cellular lipid composition and leads to stimulation of mitochondrial respiratory complex I activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="23">Endoplasmic reticulum membrane</location>
            <topology evidence="23">Lipid-anchor</topology>
            <orientation evidence="23">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Mitochondrion outer membrane</location>
            <topology evidence="24">Lipid-anchor</topology>
            <orientation evidence="24">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
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        <property type="nucleotide sequence ID" value="XM_004548435.4"/>
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        <property type="protein sequence ID" value="ENSMZEP00005002028.1"/>
        <property type="gene ID" value="ENSMZEG00005001636.1"/>
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    <dbReference type="KEGG" id="mze:101473685"/>
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        <property type="component" value="LG17"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
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        <property type="term" value="F:NADH dehydrogenase activity"/>
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    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
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        <property type="entry name" value="cyt_b5_reduct_like"/>
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        <property type="entry name" value="CBR-like"/>
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        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
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        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
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    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
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    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
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    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
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        <property type="entry name" value="FPNCR"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
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    <keyword evidence="10 27 28" id="KW-0274">FAD</keyword>
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    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00047026"/>
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            <dbReference type="ARBA" id="ARBA00047465"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
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            <dbReference type="PIRSR" id="PIRSR601834-1"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361226"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="299" mass="33850" checksum="DB6742AA4039F21B" modified="2019-02-13" version="1">MLSYIIGLIRGGFDSIINLIFRLLFQKKRPAITLEDPNIKYALRLIDKEIVSHDTRKFRFALPSPEHVLGLPIGQHIYLSAKIDGKLVVRPYTPVSSDDDKGFVDLVVKIYFKDINPKFPEGGKMSQYLESLRINDTIDFRGPSGLLVYKGKGVFAIQPDKKSPAEMKTAKHLGMIAGGTGITPMLQLVTAIMKDPDDKTVCHLLFANQTEKDILLRPELEDIQVSHPDRFKLWFTVDRAPENWEYSKGFISEDMVREHLPPPSNETLILMCGPPPMIQFACNPNLDKVGHADSRRFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXD8</accession>
    <name>A0A3P9AXD8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Arkadia family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004549803.1">
        <property type="nucleotide sequence ID" value="XM_004549746.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXD8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002350"/>
    <dbReference type="Ensembl" id="ENSMZET00005002457.1">
        <property type="protein sequence ID" value="ENSMZEP00005002350.1"/>
        <property type="gene ID" value="ENSMZEG00005001861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477934"/>
    <dbReference type="KEGG" id="mze:101477934"/>
    <dbReference type="CTD" id="572251"/>
    <dbReference type="GeneTree" id="ENSGT00940000156997"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16682">
        <property type="entry name" value="RING-H2_RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000058">
        <property type="entry name" value="E3 ubiquitin-protein ligase Arkadia isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF203">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="345" mass="39492" checksum="C7B5016CA60E6A3C" modified="2019-02-13" version="1">MVLVHVGYLVLPVFGSVRNRGAHFTRHQHSHATSCRHFHLGAPQAPISAEFPLGHASQPPQTGLATHLPPTHHPPLTALPGPPQFQDVPGPSFLPQALHQQYLIQQQLLEAQHRRILPHSRRAQERIPLNPHRLRSGYEYSPPLHVPQPMTQQPRYLAEGTDWDLSVDAGLPHHQYQLQQLPQHYQHYLASPRMHHFPRNTSSAQVVVHEIRNYPYPQLHLLALQSLNPSRHATAVRESYEELLQLEDRLGSVSRGAVQTTIERFTFPHKYKKRKPLQLKIGEEEETDVDEKCTICLSMLEDGEDVRRLPCMHLFHQGCVDQWLATSRKCPICRVDIETQLNPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXX8</accession>
    <name>A0A3P9AXX8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024658727.1">
        <property type="nucleotide sequence ID" value="XM_024802959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXX8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002545"/>
    <dbReference type="Ensembl" id="ENSMZET00005002658.1">
        <property type="protein sequence ID" value="ENSMZEP00005002545.1"/>
        <property type="gene ID" value="ENSMZEG00005002017.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463927"/>
    <dbReference type="GeneTree" id="ENSGT01090000259985"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF19">
        <property type="entry name" value="SINGLE IG IL-1-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018075046" evidence="8">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="119"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="518" mass="58227" checksum="5E0EE91AA4D167F0" modified="2019-02-13" version="1">MAVILVAFTLMCSGLWDRGLLAVGQTCVDESRFKEQAAFVGHPYQLQCPLKIVQSTSQTQLTWQKDCVQLPTNESKIYLDFNSLNLEDQGNYTCMQQSNSTVTFTVRLLVKESQCSKAPEFKPNGGSTTLWENVGSTVKLNCTALLFWDPAEKQCDTTLQWSKDGHPLNNHTLSSLNTSSWSPGANQLMVNSFLVITLRELEDFGLYSCTVRNISADFSLKNLGSPSHTGAVIAAVILLLFLALAAVIYSRCHLNIKLWYKNSYGDYELNDGKLYDAYISYVNNDYDRKFVNFVLKPHLENINGYKVHLNDNDILPGADPSAELLMNISRSRRLIVLLSFAYLEQDWCSSNFRQGLLHLLELCQQPIFILLDAQYKRMRPEFKQLLSEHQHCLTILTWRHNSVTPSSVFWKELALAMPRSVVFHKESAGDPQTLLEDDKDPMLTLQPDYLNCRSDTDPAGDLGLRLPVYKALSCKAPVLPAATSSAAEPKPSDIDISDLGSRNYAARSDFYCLVAEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZC8</accession>
    <name>A0A3P9AZC8_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Adenosine deaminase domain containing 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_004550324.4"/>
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        <property type="gene ID" value="ENSMZEG00005002346.1"/>
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        <property type="component" value="LG10"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="A_deamin"/>
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        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A_deamin"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="204"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="525" mass="58648" checksum="99EFC28B0BB6CCDC" modified="2019-02-13" version="1">MTSRGAFKYSRRGAASFWSLSDRELSPRPHCPQVHKTDDADIYTDAAGLRTNEHAAGDYDTAPEALLSEGDHRPQIEKGAVPTLSHNYDSGDIMLENEAEDSDDEPAVLSLHGMSPPESILSDEDLLTEQVKDINQPDTTTKTEVWRTEWHKNHMAAISSEKFDSLLKMCPDFYACKSHMAAFVLIREVLDTAGRPCEQYKVVAVGSGRSSCSEWLCYNGVMVHDSHAIIIARRALLRFLYKQLLLFFDADPKAKESCIFESSAASHQLQLKPKISLHLYTNQCPEGAPTNFYFKVSANDTWTSMVLQYHFKGLLVPVAYLDPSLWGAKVCCMSGSDKLCRWTVTGIQGALLSHFIQPLYITSMVLGGQKLMNQEVSDITSKRLGDGWQIFLPQSYKKHDIVFVCGDYVGPVVPSLHHENLSINWCLGDQDIEVLDSSKGLIVEGSPSVSVPGYSSRLCKRALYSYFLKVAQLGGHTYLLELPTYHSVKVEASVYQTVKELVRQQFLENHAGLWNSKKLVDCFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZT9</accession>
    <name>A0A3P9AZT9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 106b</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cichlidae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004569826.2">
        <property type="nucleotide sequence ID" value="XM_004569769.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZT9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003195"/>
    <dbReference type="Ensembl" id="ENSMZET00005003323.1">
        <property type="protein sequence ID" value="ENSMZEP00005003195.1"/>
        <property type="gene ID" value="ENSMZEG00005002483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477061"/>
    <dbReference type="CTD" id="503711"/>
    <dbReference type="GeneTree" id="ENSGT00390000013183"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031591">
        <property type="entry name" value="CCDC106"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16477:SF3">
        <property type="entry name" value="COILED-COIL DOMAIN CONTAINING 106B ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16477">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15794">
        <property type="entry name" value="CCDC106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="359" mass="41035" checksum="18470034A2B19EFF" modified="2019-02-13" version="1">MNPSTSREDASPPEHYMPQSSLAAAASSSSAAGGGGGGGGLYLNAYEVSFPLEENIERPPPYHLNQGQQMMDEPVVQEPPHSQYSTFILISNLRAHLYVTLEKNAWLQKRIEELEEERNFLRCQLDRFIVSMRSPEEWSGDAQRGVKIQPASSPSPPSPMTTRSGMTLKRIQGSGSRSRRNAAVTKQEFHVEEDKYYTEDEYVEEEEEEEEEEEDVDSSVEKGIRKKGRGRVSGEPRMKMRRVFRITHGRERQRVKDPDGVLIRYKKILSTYQRVRSMSRAFQIHGVDRNTMASTSPIAELLLVAPEKVSEVGEFEASKEKLLDYARRCYKTMDDETHAKVQTMKKTHKLLPISYRFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZX8</accession>
    <name>A0A3P9AZX8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Recoverin 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004569831.1">
        <property type="nucleotide sequence ID" value="XM_004569774.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZX8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003221"/>
    <dbReference type="Ensembl" id="ENSMZET00005003351.1">
        <property type="protein sequence ID" value="ENSMZEP00005003221.1"/>
        <property type="gene ID" value="ENSMZEG00005002504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478379"/>
    <dbReference type="KEGG" id="mze:101478379"/>
    <dbReference type="GeneTree" id="ENSGT00940000159441"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036368">
        <property type="term" value="P:cone photoresponse recovery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF166">
        <property type="entry name" value="VISININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="192" mass="22284" checksum="CD2065EF6534E4A4" modified="2019-02-13" version="1">MGNSKSGAVSKEILEDLKLNTKFSETEIVQWYENFKKQCPNGRITKEEFQTIYTKFFPESDANTYAQHVFRSFDTNDDGTLDFKEYIIALHMTSTGKTTRKLEWAFSLFDVDKNGYITKSEVSEICTAIFKLIPKEEIEKLPEDENTAQKRADKLWNYFDKGDNDRIAEGEFIQGILDNDDALRLIQYSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B056</accession>
    <name>A0A3P9B056_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetratricopeptide repeat protein 30</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell projection</location>
            <location evidence="1 9">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TTC30/dfy-1/fleer family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004556467.1">
        <property type="nucleotide sequence ID" value="XM_004556410.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B056"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003320"/>
    <dbReference type="Ensembl" id="ENSMZET00005003452.1">
        <property type="protein sequence ID" value="ENSMZEP00005003320.1"/>
        <property type="gene ID" value="ENSMZEG00005002536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469664"/>
    <dbReference type="CTD" id="797829"/>
    <dbReference type="GeneTree" id="ENSGT00390000010116"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070738">
        <property type="term" value="F:tubulin-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036372">
        <property type="term" value="P:opsin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000186">
        <property type="entry name" value="Tetratricopeptide repeat domain 30A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000211">
        <property type="entry name" value="tetratricopeptide repeat protein 30B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039941">
        <property type="entry name" value="TT30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6 9" id="KW-0969">Cilium</keyword>
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    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="40"/>
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        <location>
            <begin position="360"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0D4</accession>
    <name>A0A3P9B0D4_9CICH</name>
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        <submittedName>
            <fullName evidence="16">Mucolipin TRP cation channel 1</fullName>
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    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
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    <comment type="subcellular location">
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            <topology evidence="2">Multi-pass membrane protein</topology>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="Ensembl" id="ENSMZET00005003315.1">
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        <property type="gene ID" value="ENSMZEG00005002476.1"/>
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        <property type="entry name" value="Mucolipin 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="325"/>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B0S2</accession>
    <name>A0A3P9B0S2_9CICH</name>
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        <recommendedName>
            <fullName evidence="10">LSM family member 14B</fullName>
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        <name type="scientific">Maylandia zebra</name>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        <property type="entry name" value="PROTEIN LSM14 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11030">
        <property type="entry name" value="Nucleocapsid-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="FFD box profile" evidence="6">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="3">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="4">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30142" checksum="5095B2938AAA514B" modified="2019-02-13" version="1">MCVIRFPLHLVQLSSQFLSGEVKLGVRPQLPVAGIDIILGNDLAGGTVFPSPEVVDIPLTNNSGFDRATSKAVQTVSVKTFRQRRGASGSQQQQQQNRRQPKGTRRTNIQTTRVIEATMQSDPSRVTFQDSQQQNAETRPPARKRQGPRRHRNRRRDFDFDSSNTQFIKEALEKKLQEGLNLKDGNSEGREKVGLQLSSGEDHFGPKCYYDKAKSFFDNISSDNGLRLTWAEERKRNLETFGVPGRFLRGQGFRGGRQCFGGGCSARAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2D3</accession>
    <name>A0A3P9B2D3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane 4 superfamily member 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TMEM47</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM47 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570268.1">
        <property type="nucleotide sequence ID" value="XM_004570211.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012779837.1">
        <property type="nucleotide sequence ID" value="XM_012924383.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2D3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003897"/>
    <dbReference type="Ensembl" id="ENSMZET00005004058.1">
        <property type="protein sequence ID" value="ENSMZEP00005003897.1"/>
        <property type="gene ID" value="ENSMZEG00005003009.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005004060.1">
        <property type="protein sequence ID" value="ENSMZEP00005003899.1"/>
        <property type="gene ID" value="ENSMZEG00005003009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477539"/>
    <dbReference type="KEGG" id="mze:101477539"/>
    <dbReference type="CTD" id="83604"/>
    <dbReference type="GeneTree" id="ENSGT00530000063484"/>
    <dbReference type="OrthoDB" id="8655982at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000010">
        <property type="entry name" value="transmembrane protein 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015664">
        <property type="entry name" value="P53_induced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399">
        <property type="entry name" value="P53-INDUCED PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14399:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="181" mass="19827" checksum="A04A552FC4148C57" modified="2019-02-13" version="1">MASSVSGTEEVRVTALTPLKLVGLVCVFLALCLDVGAMLSPAWVTADDQYSLSLWASCWKPVSSEDWSCNSTLATDWQIATLALLLGGAALTLLAFLVALFSLCFGSRSRCYKPVAVMLFSAVVLQVCSLVLFPIKFIETVSLRIYHEFNWGYGLAWGSTIFSFGGALLYCLNPKNYEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2F1</accession>
    <name>A0A3P9B2F1_9CICH</name>
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        <submittedName>
            <fullName evidence="14">Neural cell adhesion molecule 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2F1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003917"/>
    <dbReference type="Ensembl" id="ENSMZET00005004078.1">
        <property type="protein sequence ID" value="ENSMZEP00005003917.1"/>
        <property type="gene ID" value="ENSMZEG00005003013.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166537"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009138">
        <property type="entry name" value="Neural_cell_adh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF29">
        <property type="entry name" value="NEURAL CELL ADHESION MOLECULE 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01838">
        <property type="entry name" value="NCAMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018195316" evidence="11">
        <location>
            <begin position="24"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="114"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="208"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="299"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="388"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="492" mass="54303" checksum="48DA54EB74797D7E" modified="2019-02-13" version="1">MNQPTRILTLALLLLQLMDSIDAKMSIISTKLDFKVGDEILLLCKAGAEGDITWQKDGEDIDDEEIVNKLDEASSKLVIKKATMQDAGRYTCHCDFDSGHKDDAQIQLFVYDGPSFGSTKTYHEFLEGTDGLVPCLVTGQPQVDVQWFKNQQEISNVGGHMRKQSDNTLRIEKVKREDAGTYVCRAQIRGRPSIFMELSVSVVVNAPPTVRLREEVKKVLAGPETNVSLLCLVDGLPQPNITWTMPVQFNPSRHHFNSDSSQLTIQSVVREDFGEYVCTATNKIAESSATIMLHVFEAPEVFVSAEQQRVLVGEAVSVSCNVTGHPHPELHWLNKQNGQTLSSTSGRVRVVDNVLMIDEVVPSDGGLYSCMAISSSGNASRDVAVYTQPGPPLYLSVSAGPASVHFSLKTTPVSGGTPITSFVLQWKEKPTEQWKENTVPATDPLVINLKPYTSYTVRLSALNAVGRGKFSETHNVHTQGIRKFFTHYQHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2N1</accession>
    <name>A0A3P9B2N1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plastin 1 (I isoform)</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004540203.1">
        <property type="nucleotide sequence ID" value="XM_004540146.5"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004540204.1">
        <property type="nucleotide sequence ID" value="XM_004540147.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2N1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004007"/>
    <dbReference type="Ensembl" id="ENSMZET00005004169.1">
        <property type="protein sequence ID" value="ENSMZEP00005004007.1"/>
        <property type="gene ID" value="ENSMZEG00005003068.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101475009"/>
    <dbReference type="KEGG" id="mze:101475009"/>
    <dbReference type="CTD" id="5357"/>
    <dbReference type="GeneTree" id="ENSGT00950000183097"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21292">
        <property type="entry name" value="CH_PLS_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21298">
        <property type="entry name" value="CH_PLS_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000031">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000263">
        <property type="entry name" value="plastin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF27">
        <property type="entry name" value="PLASTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="121"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="265"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="395"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="516"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="633" mass="71631" checksum="5BAFF3BC2D51FCC8" modified="2019-02-13" version="1">MDSHIIQISRDDLEDLKEAFNKIDIDNSGYVSEWELQELFKEASFSLPGYKVREIVETFIAGDTNKDGKISFEEFVSIYQDLKSRQISETFKKIVSRRDGIRSFGGTSGISSEGTQHSYADEEKVAFVNWINKSLAKDPDCQHLLPMDPDDESLFTSVRDGILLCKMINHSQPDTIDERVINTRKPSTFHMRENLVLALNSASAIGCTVVSMDAHDLMAGKPHLVLGLLWQVIKIGLFADIEISRNEGLIALLADGESLEHLMSLSPDELLLRWVNYHLRNAGTETISNFSEDIKDSRAYFHLMDQITSCEEDEFQMRIKIDMSGLNEWDLEKRAELMLQQAARLECRQFVTPHDVTSGNSKLNMAFVANLFNMHPGLQKLLMNGGDLEHIERETREEKTFRNWMNSLGVSPHVHHLYHDLCDGLVILQLYDKVNVFVNWKKVNRPPYPALGANMKKLENCNYAVELGRDVARFSLVGIGGVNLNEGSRVHTLGLVWQLMRRYTIQVLSDLGDGERVVDQIILDWVNKMLSQNRKDTQITSFKDKLISTSLPVIDLIDVIAPGMVKFPVVARGENGVLKKDDKINNAKYAISLARKIGARVYALPDDLVEVNPKMVMTVFACLMGHGMKKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3H2</accession>
    <name>A0A3P9B3H2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">N-alpha-acetyltransferase D</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004554386.1">
        <property type="nucleotide sequence ID" value="XM_004554329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3H2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004429"/>
    <dbReference type="Ensembl" id="ENSMZET00005004631.1">
        <property type="protein sequence ID" value="ENSMZEP00005004429.1"/>
        <property type="gene ID" value="ENSMZEG00005003439.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480401"/>
    <dbReference type="KEGG" id="mze:101480401"/>
    <dbReference type="CTD" id="79829"/>
    <dbReference type="GeneTree" id="ENSGT00390000014903"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000033">
        <property type="entry name" value="N-alpha-acetyltransferase 40 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="63"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="239" mass="27352" checksum="11FDD72728863CBF" modified="2019-02-13" version="1">MGRKSNRAKEKKARRLEERAAMDAVCAKVDAANKLEDPLAAFPAFKKYDRNGLNLQIECKRVTALNPLSVEWAFELTRANMQTLYEQSEWGWKEREKREEMNDERAWYLLARDADSSPVAFSHFRFDIECGEEVLYCYEVQLESRVRRKGLGKFLIQILQLIANSTQMKKVMLTVFKQNKGAYQFFREALQFEIDETSPSMSGCCGDDCSYEILSRRTKHGEASAGHTHGGGHCGGCCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3N8</accession>
    <name>A0A3P9B3N8_9CICH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
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            <taxon>Neoteleostei</taxon>
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            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3N8"/>
    <dbReference type="Ensembl" id="ENSMZET00005004582.1">
        <property type="protein sequence ID" value="ENSMZEP00005004382.1"/>
        <property type="gene ID" value="ENSMZEG00005003407.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234906"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="117" mass="12880" checksum="0F62B94AE1D6DDE3" modified="2019-02-13" version="1">MASLCSAEKLTMLLMKLSLIITCLIFFQSFVSSPSIRQIDSRASLTAAGGLVIARTSTRCCRLIELTHQWFVLGQPCVKQSFMANSVQGRNNNIWGCHLVGFHFNLGHFALPGLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B4M1</accession>
    <name>A0A3P9B4M1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DELTA-sagatoxin-Srs1a</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nematocyst</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_024658055.1">
        <property type="nucleotide sequence ID" value="XM_024802287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B4M1"/>
    <dbReference type="Ensembl" id="ENSMZET00005004937.1">
        <property type="protein sequence ID" value="ENSMZEP00005004732.1"/>
        <property type="gene ID" value="ENSMZEG00005003680.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:106675524"/>
    <dbReference type="GeneTree" id="ENSGT00940000164286"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042151">
        <property type="term" value="C:nematocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051715">
        <property type="term" value="P:cytolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046931">
        <property type="term" value="P:pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050677">
        <property type="entry name" value="Actinoporin_PFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009104">
        <property type="entry name" value="Anemon_actinoporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40388:SF2">
        <property type="entry name" value="ACTINOPORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40388">
        <property type="entry name" value="BRYOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06369">
        <property type="entry name" value="Anemone_cytotox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0166">Nematocyst</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="4" id="KW-1053">Target membrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="164" mass="18488" checksum="48328BD453E3CED7" modified="2019-02-13" version="1">MGLPTHRQCSIEIQNKTTTFTLCNPRMHIVSGSCSSPLPPTLSPYENGNALFIKKPHTACGSVTVFTYDLQHVSTLQFNGRVAVMFSVPYDFNFYSNWYAVGVFDMDKACDQHLYDEMYNKSEQKFVRGKAKGPSLTYRGAYITVRATMSDTYQPILKVAICNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5T0</accession>
    <name>A0A3P9B5T0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Si:dkey-34d22.2</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004551007.1">
        <property type="nucleotide sequence ID" value="XM_004550950.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004551008.1">
        <property type="nucleotide sequence ID" value="XM_004550951.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5T0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005147"/>
    <dbReference type="Ensembl" id="ENSMZET00005005372.1">
        <property type="protein sequence ID" value="ENSMZEP00005005147.1"/>
        <property type="gene ID" value="ENSMZEG00005003999.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469648"/>
    <dbReference type="KEGG" id="mze:101469648"/>
    <dbReference type="CTD" id="550378"/>
    <dbReference type="GeneTree" id="ENSGT00940000164873"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001583">
        <property type="entry name" value="RAB42, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="222" mass="25613" checksum="E695EF8822346563" modified="2019-02-13" version="1">MDLTLWQYQFRIIMLGDSAVGKSSLLKRYTEDLFMESINETVGVDFYVHFLEVEPGIRVKLQFWDTAGQERFRSVTRSYYRNSVGGMLVFDITHRASFDHIKDWHAEVCERVQPHKVLFVLVGQKNDRDAHRERAVSREEAEKLAQQLGTPYVEASAKSGQHVKECFELLTRRIYQGLLSGEIELQEGWDGVKCTVPQALQLQRANMPQPRTATKDKKKCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B656</accession>
    <name>A0A3P9B656_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxysteroid (11-beta) dehydrogenase 1-like a</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B656"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005366"/>
    <dbReference type="Ensembl" id="ENSMZET00005005595.1">
        <property type="protein sequence ID" value="ENSMZEP00005005366.1"/>
        <property type="gene ID" value="ENSMZEG00005004158.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162487"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051253">
        <property type="entry name" value="11-beta-HSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="201" mass="22596" checksum="2E1A95DA45E38D19" modified="2019-02-13" version="1">LGAQKAFYIAADMANEADPDKVVDYALENPFSMWKGMWITPNETMLIHECFFVKVNFFSYIQMAWKALPSLEQNKGSLVVVSSLLGKITSPFVAPYSSTKFALNGFFGSLRHELAMKKSNVSISVCTLGLIDTDSAMEKVRGVTDVPAYPATDAALNIIITGSTRQPELFYPWFTYFIVITKDWFPSLTDYMTQNSYNYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B682</accession>
    <name>A0A3P9B682_9CICH</name>
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            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="gene ID" value="ENSMZEG00005004186.1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Thioredoxin-like_fold"/>
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        <property type="entry name" value="NUCLEOREDOXIN-LIKE PROTEIN 1"/>
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    </dbReference>
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        <location>
            <begin position="32"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13905"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="207" mass="24786" checksum="61CEDA57FA7E7D64" modified="2019-02-13" version="1">MVDLFLNRVLIENNWDQDELNTEREIMGILENRIVMLFFASAECEKCLKFVPVLNDFFKRVKDPAYIEYPKLLALIYISLDQSEEKQEKFLKELHKKVLFLAFEDPYRKELQTMFKVKDVPTIVVLRPDGSVLSPNAVRDICRFGCDCFQNWQESAELVERSFMLNEEFDNLNLRSATDPVRRVKYKTEDDKRKKRWWKHLGEIFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6M3</accession>
    <name>A0A3P9B6M3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cathepsin L.1</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pseudocrenilabrinae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
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    <dbReference type="STRING" id="106582.ENSMZEP00005005540"/>
    <dbReference type="Ensembl" id="ENSMZET00005005776.1">
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        <property type="gene ID" value="ENSMZEG00005004286.1"/>
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        <property type="component" value="LG19"/>
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        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
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    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00645">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="148" mass="16136" checksum="C951F8E10E334C0F" modified="2019-02-13" version="1">MDYAFQYIQANGGIDTEESYPYEAEDGKCRYNPDNIGATSTGYTDVTKGDEDALKEAVATIGPVSVAIDASQMSFQFYESGVYNEPQCSSSELDHGVLAVGYGTEDGNDYWLVKNSWGLEWGDKGYIKMSRNKSNQCGIATAASYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6Q0</accession>
    <name>A0A3P9B6Q0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SWI/SNF related BAF chromatin remodeling complex subunit D1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMARCD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547674.1">
        <property type="nucleotide sequence ID" value="XM_004547617.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6Q0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005472"/>
    <dbReference type="Ensembl" id="ENSMZET00005005703.1">
        <property type="protein sequence ID" value="ENSMZEP00005005472.1"/>
        <property type="gene ID" value="ENSMZEG00005004231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479037"/>
    <dbReference type="KEGG" id="mze:101479037"/>
    <dbReference type="CTD" id="6602"/>
    <dbReference type="GeneTree" id="ENSGT00940000156629"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060216">
        <property type="term" value="P:definitive hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061053">
        <property type="term" value="P:somite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021510">
        <property type="term" value="P:spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17674">
        <property type="entry name" value="SWIB_BAF60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.245.10:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated regulator of chromatin subfamily D member 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038041">
        <property type="entry name" value="SMARCD1_SWIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="4">
        <location>
            <begin position="289"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="514" mass="58417" checksum="F14D330A061836BE" modified="2019-02-13" version="1">MAARGGFQSAPTGGGGAMGPGPPVPGAGPGMGPGTPSGRMGPSAAAQNHMYRSPMPGPGYPRPGMPPSSRMTPQGPAMGPPGYGNSPVSRPGMPGVMDPSRKRPAPQQIQQVQQQQNRNQHTKKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKPDAEDGEGTVASWELRVEGRLLEDTAVSKYEATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVGVRCTVLLMLDYQPPQFKLDPRLARMLGIHTQTRPVIIQALWQYVKTHKLQDPHEREFINCDKYLQQIFETQRMKFSEIPQRLHALLMPPEPIIINHLISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTASQQEIAGLDNKIHETIETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYYQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9A7</accession>
    <name>A0A3P9B9A7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgin subfamily A member 7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004565858.1">
        <property type="nucleotide sequence ID" value="XM_004565801.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014264707.1">
        <property type="nucleotide sequence ID" value="XM_014409221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9A7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006465"/>
    <dbReference type="Ensembl" id="ENSMZET00005006763.1">
        <property type="protein sequence ID" value="ENSMZEP00005006465.1"/>
        <property type="gene ID" value="ENSMZEG00005004987.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487982"/>
    <dbReference type="KEGG" id="mze:101487982"/>
    <dbReference type="GeneTree" id="ENSGT00390000000134"/>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF1">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="9">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="143" mass="16587" checksum="0545F98DA362C1E7" modified="2019-02-13" version="1">MAETHSLQDMRQQAAITAKVFIQRDYSSGTMCQFQTKFPSELENRIDKQQFEETVRALNNMYAEAEKLGSQSYIEGCLACLTAYTVFLCMETHYEKVLKKIAKYIQEQNDKIYAPRGLLLTDPIERGLRVVEITIFEDRSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9B2</accession>
    <name>A0A3P9B9B2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="7">2.3.2.13</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="7"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9B2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006470"/>
    <dbReference type="Ensembl" id="ENSMZET00005006768.1">
        <property type="protein sequence ID" value="ENSMZEP00005006470.1"/>
        <property type="gene ID" value="ENSMZEG00005004976.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244866"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF80">
        <property type="entry name" value="TRANSGLUTAMINASE 5,-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="9">
        <location>
            <begin position="281"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="641" mass="71830" checksum="6624113E19BF0C64" modified="2019-02-13" version="1">MLTVFNVSFSQLADLRIKYVDLEQSENLESHRTNGFRNTKSLVVRRGAPFKVSVQLEGQPFNPKINTLRVKIMLGFCLCNLYAVMPVTFSKSSSKSSWNAYIDPEEWNPLKPSIYIYSPASASVGSYRFQLCVLTQDGKKSSAYGNFILLCNPWCSEDTVYIPFEDQREEYIQSDFGLLFMGSGTNIVERPWSFDLYESGVLEACLNLLQVSPQHKKNRKMDYLNRNNPVYLSRVVSAMINSEDDRGVLKGNWTGDFKQGVSPSMWTGSGDILRKWNQSGNSPVKYGQCWVFAAVMCTVMRVLGIPCRVITNFNSAHDTDGNLVIEEYYSATGQKLNLTKDSIWNFHVWVECWMTRRDLESGMDGWQVLDPTPQQRSGGVYRCGPAPVKAIKNKRVDLFYDVPFVYASVNADIHTIILGQGQVLGFSKDTERVGSLICTKAVGFPRLQKITGDYKYIKRLFHVYSAGSSQGVLVFLTLDKSPIVGEPVSFSVKIMNKQNVAKMTVVAEDPLAQYEDVVGDNLINLAVVVEDTASQERVLSSEEFNITSPQLIIQVADEKSIKQHSKQTALVTFINPYSHPVSGVLTVAGAGLLQGKVQFRVDQPIPFMPNMVGEKMLQASLWLTNMNVTIRGFKMVSVNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9T9</accession>
    <name>A0A3P9B9T9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AlkB homolog 1, histone H2A dioxygenase</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B9T9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006650"/>
    <dbReference type="Ensembl" id="ENSMZET00005006949.1">
        <property type="protein sequence ID" value="ENSMZEP00005006650.1"/>
        <property type="gene ID" value="ENSMZEG00005005130.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004599"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035515">
        <property type="term" value="F:oxidative RNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035513">
        <property type="term" value="P:oxidative RNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="6">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="236" mass="25935" checksum="FBCC2AAD6F6E1702" modified="2019-02-13" version="1">MDSSDWLSTGNVTGWKTRSADSPGEAALGHAGLSLQLGHKAACGFPGFISEAGILNYYRSDSSLGIHVDESELDHTRPLLSFRWDACFFTDPPTAMLMHSGDVMVMSGPSRLLYHAVPRILPPPPGRLALETGGSIQTPPPQEGSVVEPVSEEEWAVCSRYIQSSRVNVTVRQVLAPGQKFPETPRSHQWFAICHHQNTPQIPQMIHFLLNHSDVTDHVTLAKRIKLRYSASEAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BA25</accession>
    <name>A0A3P9BA25_9CICH</name>
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        <submittedName>
            <fullName evidence="15">SH3 and cysteine rich domain</fullName>
        </submittedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004540529.1">
        <property type="nucleotide sequence ID" value="XM_004540472.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BA25"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006744"/>
    <dbReference type="Ensembl" id="ENSMZET00005007044.1">
        <property type="protein sequence ID" value="ENSMZEP00005006744.1"/>
        <property type="gene ID" value="ENSMZEG00005005206.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486552"/>
    <dbReference type="CTD" id="6769"/>
    <dbReference type="GeneTree" id="ENSGT00950000183092"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 3 isoform 2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035508">
        <property type="entry name" value="STAC1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF3">
        <property type="entry name" value="SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00018">
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    </dbReference>
    <dbReference type="Pfam" id="PF07653">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16664">
        <property type="entry name" value="STAC2_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="127"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="318"/>
            <end position="377"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="242"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <end position="281"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="435" mass="48485" checksum="8FB80A5DC5ECD2E2" modified="2019-02-13" version="1">MIPPASTIQDESGGKEDERDQNETPKSPTANASQQESKLQRLKRSLSFKTKSVRSKSADNFFRNSSENKTELLSDVSSSTGHLCNIGMAPPHNTNLPIPPVPPAIPCAPPPTSRSQPRNPMQLDSAGHCFMEHIFKKPTFCDVCNHMIVGTTAKHVVFLAGNTAKHGLRCKACKMSLHHKCENGVGQQRCMGKLPKGFRRYYSSPLLIQEQYGCIKEVMPIACGNKVDPVYEALRFGTSLAQRTKRASGSESPHRNSTSDLDKVPEEVVAHSSRQELSRKHSDDVFTVVENGTEQYHHPERKPDSLQMEQSMLQKDVLKLNTYVALYSFTAQESHDLEMRAGDRILVADDSNDDWWKGVIEDRIGFFPAAFAHQLRAGDQVFRCNRTFIGCKEQGQITLKEGQICVSSEGEHSGFIRVESGKKRGFVPCDVLEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BBG7</accession>
    <name>A0A3P9BBG7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 219 member B</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
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        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
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            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM219 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539798.1">
        <property type="nucleotide sequence ID" value="XM_004539741.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BBG7"/>
    <dbReference type="Ensembl" id="ENSMZET00005007548.1">
        <property type="protein sequence ID" value="ENSMZEP00005007238.1"/>
        <property type="gene ID" value="ENSMZEG00005005569.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467417"/>
    <dbReference type="KEGG" id="mze:101467417"/>
    <dbReference type="CTD" id="57184"/>
    <dbReference type="GeneTree" id="ENSGT00390000000860"/>
    <dbReference type="OrthoDB" id="9451307at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029339">
        <property type="entry name" value="FAM219"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281">
        <property type="entry name" value="PROTEIN FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31281:SF2">
        <property type="entry name" value="PROTEIN FAM219B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15260">
        <property type="entry name" value="FAM219A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="185" mass="20332" checksum="ABBCD1F6196E7619" modified="2019-02-13" version="1">MMNDILEEPEKDSLLEAQQDSQGLSGPSSGTRPKSIDGGIRPVEKRGPYIMSRAPAIHLKLQKHREMARKALKKKALSPGPPVTHQPRQGAKRMVKYNKGYAALSQHAEDTLVAIDSDSDEEIDFEQYSSGYSSAEIHPDLSKQLLQDGYRLDEIPDDEDLDLIPPKAMGSSVCCCSEGPSCPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCC6</accession>
    <name>A0A3P9BCC6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pleurocidin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCC6"/>
    <dbReference type="Ensembl" id="ENSMZET00005007859.1">
        <property type="protein sequence ID" value="ENSMZEP00005007543.1"/>
        <property type="gene ID" value="ENSMZEG00005005776.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000178984"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Antimicrobial12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08107">
        <property type="entry name" value="Antimicrobial12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018059873" evidence="6">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="62" mass="7400" checksum="A4AB2911D9BB2E92" modified="2019-02-13" version="1">MKSAVIFLALFMVFMMAEPGECFWHNLLKGENCNYFTKSKELVKSMKADLQNYKQLRQREFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCK8</accession>
    <name>A0A3P9BCK8_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCK8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007622"/>
    <dbReference type="Ensembl" id="ENSMZET00005007939.1">
        <property type="protein sequence ID" value="ENSMZEP00005007622.1"/>
        <property type="gene ID" value="ENSMZEG00005005829.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000179779"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33639" checksum="138ACC1DA7235D8E" modified="2019-02-13" version="1">SFCPFRPVYWLGNDTLRVFSGLKAKDSVMPKSVVVLQGGEKESFFHRAFGVTEAHCLGAIDVDSFLFVPKLPESYAAWIGKEKYAVDEVYFTLSLIRLSSIMVILGLLMTGRLQMEICGEYLFGGWGLFLLHEEFFHSTIFSEVTSEIYTRFCTQACKICSLFDMGGECYCFTFLTLFLFIDKNVYFEGVKVHLEELVKIGILHGSVKDMMKVHLGSVIMPHGLGHLLGIDVEDVGGYPEPGSRNLLMGHLVQEWMVLMVEAGTYLISHLSFINNQVLAHFFGFGGISMLLFVYVGPIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGV5</accession>
    <name>A0A3P9BGV5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGV5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009128"/>
    <dbReference type="Ensembl" id="ENSMZET00005009477.1">
        <property type="protein sequence ID" value="ENSMZEP00005009128.1"/>
        <property type="gene ID" value="ENSMZEG00005006933.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000046773"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000008">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008557">
        <property type="entry name" value="PRK11493.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="177"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="300" mass="33447" checksum="7F158CDE08117F60" modified="2019-02-13" version="1">MQRLVMAAQTRALVSGQWLANAVRNDLIGPKLRVLDASWYLPKAKRNTREEFAQKHIPGSSFFDLDECSDKNSAFDHMLPTASYFSQYVGDLGIGNDTHVVVYDTSDTGAYSAPRVWWMFRLFGHSLVSLLDGGFKNWLVDGYPVTSEYLKPESREFKATLNQSWVKSYEDVLENIRTKQVQVVDARSPGRFKGTEPEPRDDILPGHYPGAINIPYTTLLDPSGKVKDTESLAEIFKDAGVDMTRPFWASCGSGITACQVILAAHLLGHPGVCLYDGSWCEWFQKASPELIISEGEGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHS8</accession>
    <name>A0A3P9BHS8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Plexin A4</fullName>
        </submittedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005009291"/>
    <dbReference type="Ensembl" id="ENSMZET00005009641.1">
        <property type="protein sequence ID" value="ENSMZEP00005009291.1"/>
        <property type="gene ID" value="ENSMZEG00005007001.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244850"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007414">
        <property type="term" value="P:axonal defasciculation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001763">
        <property type="term" value="P:morphogenesis of a branching structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01180">
        <property type="entry name" value="IPT_plexin_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01181">
        <property type="entry name" value="IPT_plexin_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12790">
        <property type="entry name" value="RasGAP_plexin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000005">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000006">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000123">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000006">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000071">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000329">
        <property type="entry name" value="Plexin A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF34">
        <property type="entry name" value="PLEXIN-A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017985695" evidence="15">
        <location>
            <begin position="27"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1248"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="16">
        <location>
            <begin position="34"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1274"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1904" mass="214249" checksum="729B82B9E013CF6A" modified="2019-02-13" version="1">MTSFTRIRTYFLLCCFLSSLVLPVTSQTVVQAPQTHTAGSQVITALLQEEEYASFHAENPEWTFNHLAVDYRNGNVYLGAVNRIYKLSPNLEVQKSHETGPDEDNRKCYPPRIVQPCSEPLTLTNNVNKMLLMDYRENRLLACGSLYQGICKILRLDDLFKLGEPFHKKEHYLSGVNESGSVFGVIVSYGNASPDMLFVATAVDGKPEYFPTISSRKLARNSEEDGMFAYVFHDEFVASMIKIPSDTFTVIPDFDIYYIYGFASGNFVYFLTLQPEMGGGPTTGSSSAGREQVYTSKIVRLCKADTAFNSYVEVPIGCISDNVEYRLLEAAYLSKAGAILARSLDVAPDDDVLFAIFSKGQKRRPRQASQDSALCVFSLRKINEKIKERLQSCYKGEGTLDLAWLKVKDIPCSSALLTIDDDFCGLDMNAPLGVSEMVRGKPLFSDAVDKMSSVIAYVYKNHSLVFVGTKSGQVKKIRVDGSSRALQYETVQAVENGPILRDMAFSSDHHYLYVMSETQVRHTNKHIHQNSSLLTQYHNHWHLSFSYVTGKEKCERSSEPRRFASDIKQCVRLSVHPNNISVSQFSVTLVLEAHNVPELSAGVNCTFENLAEMNGLVEGNRIKCSSPAEKEMPRIIVDKGDHQIVQLYLKSKETGLAFANTSFVFYNCSVHKSCLSCVSSPYQCHWCKYRHDCTHDPRTCSFQEGRVKKPEGCPQLLPAERILVPVNVVKPITLRAKNLPQPQSGQRGYECLLTIQGNEHRVPALRFNSSSVQCQNTSYFYDGMEMSSLPVELTVIWNGDFSIDNPAHNKVHLYKCDAQRGSCGLCLKADPLFGCVWCKGENRCTLKQHCANENTWLEHNGINSKCTHPRITKITPLRGPREGGTLVTIHGENLGLDFREIQGNVKVAEVDCTPIREGYIPAEQIVCEMGRAEMSQYTGNVQVCVGQCTSEFMAKSSKYYYFVIPRIISLTPSRGPVSGGTVVNITGSHFDAGSNVSVMFKDQPCTYQRRGGLWLTCRTHASLHGIGNVSVSVSIDRAHLQKDLQFEYVEDPTITKIEPEWSIFSGYTPITVTGTNLDIIQTPLIRAKYNGHETLNFCDILGPTTMVCQAPELPISLARHQEVPERPEEFGFKLDDLQITLNNTNFIYFPNPEFEPISPSGVLELKPGSPIILKGRNFLPATNSGNGKLNYTVLIGEKPCILTVSENQLLCESPNLIGRHKILARVGGIENSPGSVHITSDSPLSSTAIIGIAAAGALLILVIVAVLIAYKRKSRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEEHPVLRDLEVPGYRQEQVEKGLKLFGQLINNKIFLLCFIRTLEAQRGFSMRDRGNVASLIMTVLQSKLEYATDVLKHLLSDLIDRNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDSITGEARYSLSEDKLIRQQIDYKTLVVNCIHPENEKSPEIQVKVLNCDTISQVKEKILDAIYKNVPHSHRLKASDMDLEWRQGRGQRMILQDEDITTKIEGDWKRLNMLSHYQVPDNAVMALVPKQVTAYNSVNNSTVSRTSASKYENMIKYTGSPDSLRTRTPMITPDLESGVKVWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHNIHDPHVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYSDINKMPAISDQDMNAYLAEQSRMHMNEFNTMSSLSEIYSYVGKYTEEIVCALEQDDAARKQRLAFKLEQVVAFMSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJ98</accession>
    <name>A0A3P9BJ98_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APC membrane recruitment protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Amer family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJ98"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009977"/>
    <dbReference type="Ensembl" id="ENSMZET00005010343.1">
        <property type="protein sequence ID" value="ENSMZEP00005009977.1"/>
        <property type="gene ID" value="ENSMZEG00005007560.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063529"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019003">
        <property type="entry name" value="AMER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22237:SF0">
        <property type="entry name" value="APC MEMBRANE RECRUITMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22237">
        <property type="entry name" value="APC MEMBRANE RECRUITMENT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09422">
        <property type="entry name" value="AMER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="847" mass="94408" checksum="74546F73C708DBFF" modified="2019-02-13" version="1">MASRSVDEPPSDTRNLPSVSEEPSRCYPDDVVGELQPDTMNATVKSQKSGKFRRTALTFFGVRKSICILPSFFGGRSKNQNKWSTKKGISKSKTHDGLCKVSQDDGLRSGYASAGDFDNECSHPAAEQKSLTLGRQKKGLRSLFHSFKHHRNHRNDGLAKTEVIAMSSPHCKKEVPVVRDISQFVTECLGSEPNVPDFVDVTSDISIGPERNEANVQTVLERSLEKESPKSEVDEQVSDDQLEEMNLIAVVSSEYEEPARGHSEPCLKLQMMSEASETPAGSTDQLDMIFGDVASLKSFDSLTGCGDIIADQEDDSITESTVSGERSRNGGKRASCYLTYQGGGEEMASPEDLDETCLQDFWGNNSSKEVCYSCNQDHTDVTAELTTSHNMDLLNSSSGQQAGGMDSSSIADVLTPQSEHQESVPNSDEGYYDSTTPGPEEGREKTDRFQTERLPRDSYSGDALYELFAPDESLVSPRYESKSKLPISKLGDYSSQPADVTDSAFVPEMNKLQISAELYKVHDFLEMPSTCSNSLELAHSVVCRPEIAMNKNCNLNTKAQASVRVDHIELHIYDQKEDVLASSEKRAKSINADTEKRHSSLSFQSMSDPDFETFCEPKEEHLEENKPVALPYRNITSPSEDSNNDMDDGQTVCFSQALVDFTKHTQMLSNLHDNVDDLETNSAITPNVEALPTIVTFDVVDMHNEGEYDEQIHMELEEDISSPYQEFEESYLQKDAFAECDYQMLDLYEQNMISNTWAVASLPRHLGLTRVSQSMPNPLSLERRSRSLDTESLELKMPDSYRENRDAIISCPQTEEDLERDASPYYKKNVVVSASEQLKLTHLSRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJN4</accession>
    <name>A0A3P9BJN4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJN4"/>
    <dbReference type="Ensembl" id="ENSMZET00005010495.1">
        <property type="protein sequence ID" value="ENSMZEP00005010127.1"/>
        <property type="gene ID" value="ENSMZEG00005007655.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286931"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF5">
        <property type="entry name" value="E3 UBIQUITIN_ISG15 LIGASE TRIM25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="27173" checksum="50B10E4237EFE63C" modified="2019-02-13" version="1">MNQMDQTKICCSVCLDLLKDPVTIPCGHSYCMNCIKNVACDVCTGRKMKAFKSCLFCLASYCEKHLQPHYDSPTFKKHKLVEPSKKLQENICSRHDEVMKMFCRTDQQSICYLCSVDEHKGHDTVSAAAERTERQRELESFTELIHLIPKRSSDVKQQIRSQRETEVSRVKELQEKLEQEITELKRKDAELKQLSHTEDHIQFLHNYPSLSALRRCWLQDHAIIHVWFVFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJS0</accession>
    <name>A0A3P9BJS0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Equilibrative nucleoside transporter 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Solute carrier family 29 member 4</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004560792.1">
        <property type="nucleotide sequence ID" value="XM_004560735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJS0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009891"/>
    <dbReference type="Ensembl" id="ENSMZET00005010253.1">
        <property type="protein sequence ID" value="ENSMZEP00005009891.1"/>
        <property type="gene ID" value="ENSMZEG00005007481.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005010264.1">
        <property type="protein sequence ID" value="ENSMZEP00005009900.1"/>
        <property type="gene ID" value="ENSMZEG00005007481.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101469956"/>
    <dbReference type="KEGG" id="mze:101469956"/>
    <dbReference type="CTD" id="559668"/>
    <dbReference type="GeneTree" id="ENSGT00950000182898"/>
    <dbReference type="OrthoDB" id="10014563at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032238">
        <property type="term" value="P:adenosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090494">
        <property type="term" value="P:dopamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051620">
        <property type="term" value="P:norepinephrine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051610">
        <property type="term" value="P:serotonin uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000255">
        <property type="entry name" value="Solute carrier family 29 member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="545" mass="60789" checksum="A2F0405D3CCA500C" modified="2019-02-13" version="1">MGSVGAERRRPTPAQTPEERDVWRDGGRSVWREGWREGRESGIVQSYSFDSYQLEEEEISKDAPERGVLALSEPDFEEPIPDDRYHGIYFAMLLAGVGFLLPYNSFITDVDYLHQKFKGTSIVFDMSLTYILVALLAVILNNVLVERLSMHTRITVGYILALGPLIFVSVFDVWLEKFTTKQAYVINLVSVGVVAFGCTVQQSSFYGYMGMLPKRYTQGVMTGESTAGVIISLSRIFTKLLIKDDKKNTLIFFLVSISMEMLCFLLHLLVRRSRFVRYYTSHAQGKGPGKCHDPRDNGTGYRVHHDVTAEEVRFGNGGTGASSVEEGVEDIAGGTYVRFDAPKAKMRRSWPGLRDMILHRYVVSRVIWAYMLSIAVTYSITLCLFPGLESEIRNSTLGEWLPILIMATFNMSDFVGKILAALPYDWSGGRLLFFSCLRVVFIPLFVMCVYPANEPTLSHPAWPCLFSLLMGVTNGYFGSVPMIQAAGKVPPEQRELAGNTMTVSYMTGLMVGSAVAYAAYSFTAPPTGIHSSTLNIHTPANTTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BJV5</accession>
    <name>A0A3P9BJV5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Afadin- and alpha-actinin-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004539077.2">
        <property type="nucleotide sequence ID" value="XM_004539020.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BJV5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010188"/>
    <dbReference type="Ensembl" id="ENSMZET00005010557.1">
        <property type="protein sequence ID" value="ENSMZEP00005010188.1"/>
        <property type="gene ID" value="ENSMZEG00005007701.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464534"/>
    <dbReference type="KEGG" id="mze:101464534"/>
    <dbReference type="GeneTree" id="ENSGT00940000177102"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF3">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="444" mass="51122" checksum="FCF5EC03602819D3" modified="2019-02-13" version="1">MASRFVQRKDDRQEYSDSHLFRDPSLNPLNAHPQSASWWADREEQGDSLREQLKEMDEHVARLQDMLRCERVKCGHLQLQCNQQEAELRRRELQTNRLKERLSQMTDRHGEKGPAIEVLNFPPGSRGKKEQPIKSFRSTAKREEAALRLMLERREAELREAMKLRHSLTTLLHALRVDMEQTLSESMDMAQDGDKRLDQAEEALGEHVTGGVVQSWRKVQRLLPGIMFEGQTTAGTDQEKLLAQLEAELKESQHLVRLQQQMLQDTLASPIPSELTDSYFLEEWERLQVRWAEFHHMRRTFERERQSFTDAAIRLSRERCDFEQQRASLLKQQYLYDSPLFNKGAPNNNRRESTALSLSGLGPTNISGCLPLTPSTSESGTAAVAGLHQGRGRVQTPSTPELYSSLNLPYNCRSRDVDQHLETWDAGADRIGHTPHAPHLDWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BK36</accession>
    <name>A0A3P9BK36_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin dependent kinase 2 associated protein 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDK2AP family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BK36"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010268"/>
    <dbReference type="Ensembl" id="ENSMZET00005010638.1">
        <property type="protein sequence ID" value="ENSMZEP00005010268.1"/>
        <property type="gene ID" value="ENSMZEG00005007739.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155149"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017266">
        <property type="entry name" value="DOC_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607">
        <property type="entry name" value="DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09806">
        <property type="entry name" value="CDK2AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="144" mass="15659" checksum="4C9D03B09FE75CD3" modified="2019-02-13" version="1">MCAFVFWGEWGGRVGRGPGHDPESHDWTTLLPLCVQPCGVVFELSTVANLQSPSAANLATLQSYRPLLSDYGPPSLGFSQGSTGSQVPQNKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BKX3</accession>
    <name>A0A3P9BKX3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibroblast growth factor receptor like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
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                <person name="Swofford R."/>
                <person name="Tan F.J."/>
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                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
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                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="AlphaFoldDB" id="A0A3P9BKX3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005010589"/>
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        <property type="protein sequence ID" value="ENSMZEP00005010589.1"/>
        <property type="gene ID" value="ENSMZEG00005007966.1"/>
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        <property type="term" value="F:fibroblast growth factor receptor activity"/>
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        <property type="entry name" value="IgI_2_FGFRL1-like"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1"/>
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        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="374"/>
            <end position="398"/>
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            <end position="443"/>
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            <end position="419"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="503" mass="56117" checksum="94E5FD8124E6676B" modified="2025-10-08" version="2">MHFLPLFALPRAPVSPPHIIIAYFLASSGPPRVSDKVEHRQTARVGSAIKLPCPVEGDPPPLKMWTKDARNIHSGWIRFRILRMGLKIKEVETDDAGTYICKATNGFGSVNVNYTLIVIGECGRSSRGIVMEGFKMSLSSEMSVLRPRFTQPTKMRKRVIARPVGSSVRLKCAASGNPRPDIVWLKDDRQLTEQEVGEGRQKKWTLSLKNLMPEHSGKYTCRVSNCAGEINATYKVEVIQRTNSKPVLTGTHPVNTTVDYGGTTSFQCKVRSDVKPVIQWLKRVETNEESRYNSTIEVGDHRFVVLPTGEVWSRPDGSYLNKLLISRAKEDDAGMYICLGANTMGYSFRSAFLSVLPDTKPHITPMFPQASSSLPWPVIIGIPAVIVFIFGTVLLWFCQSRKHCPPPSSPAAQVLQSSHRLPHRERDRGCAAPSSSSSSPEKDCVTSMNYEEYLAQQQQLLLGQGGPTIPAKIYPKIYTDIHTHTHSHVDGKVHQHQHIHFQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BM27</accession>
    <name>A0A3P9BM27_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcitonin gene-related peptide type 1 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Calcitonin receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Calcitonin receptor-like receptor</fullName>
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    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.</text>
    </comment>
    <comment type="function">
        <text evidence="18">May function as G protein-coupled receptor for calcitonin-gene-related peptides and adrenomedullin. Specificity may be modulated by accessory proteins. May activate cAMP-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterodimer of CALCR and RAMP1, RAMP2 or RAMP3; the receptor complexes function as AMYR1, AMYR2 and AMYR3 receptors, respectively, and respond to amylin/IAPP, calcitonin/CT and CGRP1 ligands. Interacts with GPRASP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_004547926.5"/>
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        <property type="protein sequence ID" value="ENSMZEP00005010701.1"/>
        <property type="gene ID" value="ENSMZEG00005008028.1"/>
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    <dbReference type="KEGG" id="mze:101487735"/>
    <dbReference type="CTD" id="799"/>
    <dbReference type="GeneTree" id="ENSGT00940000155380"/>
    <dbReference type="OrthoDB" id="16753at2759"/>
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        <property type="component" value="LG22"/>
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    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004948">
        <property type="term" value="F:calcitonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15274">
        <property type="entry name" value="7tmB1_calcitonin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000079">
        <property type="entry name" value="Calcitonin gene-related peptide type 1 receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="4"/>
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    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GPCR_2"/>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
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    <dbReference type="InterPro" id="IPR001688">
        <property type="entry name" value="GPCR_2_calcitonin_rcpt"/>
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        <property type="entry name" value="GPCR_2_calcitonin_rcpt_fam"/>
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        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
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    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF8">
        <property type="entry name" value="CALCITONIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00361">
        <property type="entry name" value="CALCITONINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01350">
        <property type="entry name" value="CTRFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018120988" description="Calcitonin gene-related peptide type 1 receptor" evidence="20">
        <location>
            <begin position="22"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="21">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="21">
        <location>
            <begin position="163"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="21">
        <location>
            <begin position="262"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="21">
        <location>
            <begin position="392"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="22">
        <location>
            <begin position="486"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005010701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="808" mass="93493" checksum="9FC1FAB0AD4E6A59" modified="2019-02-13" version="1">MRLMGSIWILWFLLVCRTAEGTDSISDPSLSPQQSIVEGQSVQALSQGQYKCLELSRKGRQESRTGVRCDYMWDGLLCWDETPAGTSVTQNCPHHPQLYPTEKMTKYCDESGNWIQTGSTCQQTLKDKLEKEIPDFQRDAAAEPTTEAPGVSTEKIILDNEKKCQEKMKNDPPYRKPGRYCSRTWDGWLCWDDTPADTYASRNCPDYFGDFDPTEKATKYCGADGKWFQHPDSNRTWTNYTLCATTHEKRQRKLKLLESEYRCLLKIKQEPPSTKTGPYCNRDWDGWLCWDDTPAGTTVSQSCPDYFSDLDPTERASRYCREDGQWFRHPESNKTWTNYTLCAINTKDKLKAAAQFSRDTEVNGADEATVSPTANREQQEIVRKKILDNQYKCFEKMNRDPPYNKSGLYCSRNWDGWLCWDDTPAGTYTFQNCPNYFHDFDPTEKATKYCGEDGQWFRHPDTNRTWSNYTLCNENTNAKLKSAYILFYMAIVGHALSIASLLISLAIFFYFRSLSCQRITLHKNLFCSFVLNSALTLIHLIAVVNNPEVVARNPVGCKVLQFFHMYMLGCNYFWMLCEGIYLHTLIVVAVFAEEQHLHWYYLLGWGFPLVPVSIHAVARKKYFDDNCWMSVETHLLYAIHGPIVAALLVNLFFLLNIIRVLVTKLRDTHRAESNMYMKAVRATLILVPLLGIQFVIIPWRPENRLAGEVYEYIMHILMHYQGLLVSTIFCFFNGEVQAAVKRQWMQYKTQWGQRRKDHCSMRSTSYTATSITEVPAFMYHHDCNTEHLNGRHTEDSELVALKSGDTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BMC6</accession>
    <name>A0A3P9BMC6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin binding LIM protein family, member 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BMC6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011085"/>
    <dbReference type="Ensembl" id="ENSMZET00005011468.1">
        <property type="protein sequence ID" value="ENSMZEP00005011085.1"/>
        <property type="gene ID" value="ENSMZEG00005008291.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182850"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09327">
        <property type="entry name" value="LIM1_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09328">
        <property type="entry name" value="LIM2_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09329">
        <property type="entry name" value="LIM3_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09330">
        <property type="entry name" value="LIM4_abLIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000003">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000004">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000007">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000024">
        <property type="entry name" value="actin-binding LIM protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032402">
        <property type="entry name" value="AbLIM_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051618">
        <property type="entry name" value="Actin-binding_LIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24213:SF0">
        <property type="entry name" value="ACTIN-BINDING LIM PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16182">
        <property type="entry name" value="AbLIM_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="631" mass="70685" checksum="D78D1CE4973F017C" modified="2019-02-13" version="1">MSSSAYRQDSTGGQRSSGPIRCQRCREVCKGEVVRVQETHFHVKCFTCTVCNCDLAQSGFFQKKGEYICTADYQRLYGTRCDRCDTFITGEVVSALGRTYHPKCFVCSVCSKPFPIGDRVTFSGKDCVCQQCSHTLVKSNEPIKIHGPSHCAGCGAEIKQGQSLLALDKQWHVSCFRCRTCNMVLTGEYISKDGVPYCEADYHAQYGVKCETCSRYISGRVLEAGGKHYHPTCARCARCNMMFKEGEEMYLTGCEVWHPLCKQAARAERRLRHRRLSEASISPPGSSIGSPSRVICARVENEILDYKDLAALPKVKAIYEVQQPDLISSSYQPYHRYISDDRLDTYSYGESLGTLSPYSQDYNSLDIKQRRCSSPGYIDSPTYSRQGMSPIMPRSPQHYGYPGSESGRSSPYYSQDGRPSTPTTNQPPKHFHVPATGDPNIYRKPPIYKRTDNHVDAATKSRTSEDILRSSRLSTYSPEPYSQSESDYYPYSSSPRAYRAPRRRFSTGGDEETWSHGLQRIGSGIGRMILKEEMKARSGSYDNDPWGSARNSRSGSKETLNTTSYGTTAYNNTINGSPRSQYSTDSDFVCKSASLPGYGRNGIQRPQSADCYQYQYDSGSEVNWGSRGNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNA2</accession>
    <name>A0A3P9BNA2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNA2"/>
    <dbReference type="Ensembl" id="ENSMZET00005011485.1">
        <property type="protein sequence ID" value="ENSMZEP00005011101.1"/>
        <property type="gene ID" value="ENSMZEG00005008330.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166278"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="174" mass="20433" checksum="7D0E7F5AB0F06764" modified="2019-02-13" version="1">MVRNYQRKTERGRTPPDIMLKAVRQVKMQNKSIRSTAKDFDINYRTLTRYCQKITREEIESQTAMPTTMVGYTTLRKIFSPDLEKQLVEYITRSADIYFGLSPSEVRKLAYQFAVAHELKFVPLWAEKEKASKEWFTGFLKRHTTLSLRKPEATSLSALLDEEKPKCPKRCHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNR6</accession>
    <name>A0A3P9BNR6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Si:ch211-107o10.3</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539646.1">
        <property type="nucleotide sequence ID" value="XM_004539589.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNR6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011572"/>
    <dbReference type="Ensembl" id="ENSMZET00005011973.1">
        <property type="protein sequence ID" value="ENSMZEP00005011572.1"/>
        <property type="gene ID" value="ENSMZEG00005008678.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101476276"/>
    <dbReference type="KEGG" id="mze:101476276"/>
    <dbReference type="GeneTree" id="ENSGT00940000165857"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004846">
        <property type="entry name" value="PRK06197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF26">
        <property type="entry name" value="RETINOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="329" mass="36278" checksum="170C8E2153E0907D" modified="2019-02-13" version="1">MQNYAEAVKDFTERHATCLTVVFVAGVGVLAFRRWMAGGVCRSKARLEGKTVLITGANTGIGKETALDMAQRGARVILACRDMTKARIAADEIRQKSGNGNVVVKKLDLASLQSVRDLAKDVEKNEERLDILINNAGIMMCPKWKTEDGFEMQFGVNHLGHFLLTNCLLDLLKKSAPSRIVIVSSLAHERGQIHFDDINVDKDYTPQKSYRQSKLANVLFGKELATRLNGSGVTVYSLHPGVIRTELGRHLFNSFPMWKIMLAKVFMKLVKNPWEGAQTTIYCAVDESLANSSGLYYSDCAPKKPAPQALNDAAAKKLWDLSASMVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BP91</accession>
    <name>A0A3P9BP91_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9BP91"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011734"/>
    <dbReference type="Ensembl" id="ENSMZET00005012140.1">
        <property type="protein sequence ID" value="ENSMZEP00005011734.1"/>
        <property type="gene ID" value="ENSMZEG00005008787.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156723"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000330">
        <property type="entry name" value="Apoptosis resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000008">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000013">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058906">
        <property type="entry name" value="AREL1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25915">
        <property type="entry name" value="AREL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018107436" description="HECT-type E3 ubiquitin transferase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="250"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="680"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="977" mass="112627" checksum="17344CD0C8C81D55" modified="2019-02-13" version="1">MDRRFFLTFLFCSLSWIFFWEVRWKKGKESQIEEWLKGHNLSQYRNLFEDVHTLEELSLSVLSRLEEVVKEQQRWREIAEAHIQLLRDFAFQEWLCSQNLEHYYHTLKTLGCMNLDDLSQFDSQLQLSLAAWGYYYEDYIKLSTGIKILQTSRGSRDQDYEIRLVHSLAERRLNEKWSFAGALIFGCSVALCFLIRDLMFYVIGGITVSIIAFVFTIKFLCELAARVVSFLQNEDPGRRGDRSIYDYVRGNYLDPRSCKVSWDWKEPQEVGQTMSFRVQLFYKNGQPFPAHRPVGLRVNITHIELALDIPVTQEVLQDPESNVVKVAFTVRKAGRYEVAVKLGGLNVAYSPYYKIFQPGTVVPSKTKIAYHFSTLVLTNGQRHTLQIEPRDEYGNPTSNSTSLTDEANYSVHVHSLGTADDDSLEGLYSKSVSVNKQQCQVLLRLTLKKTGCFRARISYKDQPLSNGEFDIIVLSENEKACVEKNVSTPGISIYFEAYLYSSGNYSSSSWQLPASSLLAPQRRPSMGEEEDEHDSPVEGQPEKVKKPKKVYCYISPKQLSVKEFYLKIIPWRLFTFRVCPGTKFTYYGPDPVHKYLTLVVDDGIQPPVELSCKDRNIMAATFIRFLHKNIGGSETFQDKVNFFQRELRHIHSKRPRTKTCLKVSRHAILDSSLKATRNFSVSDWSKNFEVVFQDEEALDWGGPRREWFELICKTLFDTSNQLFTRFSDNNQGLVHPNPERPPHLRLKMYEFAGRVVGKCLYESALGGAYKQLVRARFTRSFLAQIIGLRMNYKYFETDDQEFYKTKVCFILNNDVSEMDLVFAEEKYSKSGQLEKVVELISGGAQIAVTNENKMHYLNLLAQYRLASQVRDEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDINVQDFKAHAVIVGGSWHFREKVMKWFWAVVSSFTQEELARLLQFTTGSSQLPHGGFNTLCPSFQIIAAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BPH2</accession>
    <name>A0A3P9BPH2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cryptochrome circadian regulator 5</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539639.2">
        <property type="nucleotide sequence ID" value="XM_004539582.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BPH2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011832"/>
    <dbReference type="Ensembl" id="ENSMZET00005012238.1">
        <property type="protein sequence ID" value="ENSMZEP00005011832.1"/>
        <property type="gene ID" value="ENSMZEG00005008861.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101474441"/>
    <dbReference type="CTD" id="83776"/>
    <dbReference type="GeneTree" id="ENSGT00940000166058"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003914">
        <property type="term" value="F:DNA (6-4) photolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000004">
        <property type="entry name" value="Cryptochrome-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="248"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="288"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="386"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="518" mass="59720" checksum="C5442563D26AACC1" modified="2019-02-13" version="1">MAHTCIHWFRKGLRLHDNPALMAALKDCKQLYPVFILDPYLHNNACVGINRWRFLIGALKDLDGSLRKLNSRLFVVRGKPEDVLPKLFTKWKVTRLTYEYDTEPYSLQRDSKVTSLAKERGVEVIYKVSHTLYNIERIIEENNGKPPLTYTKLQAIAKTIGPPKRPIPAPTMDDMKDVKTPSSENHEKEYGIPTLEELGLDTAPLGEDLFPGGEQEALRRLDEHMKRTKWVCTFEKPQTSPNSLSPSTTVLSPYVTFGCLSVRTFWWRLTEVYRGNKHSDPPVSLHGQLLWREFFYTASLGIPSFNKMEGNSVCTQVDWDTNTDYLAAWREARTGYPFIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGQKVFEQLLLDGDWALNAGNWQWLSASTFFHQYFRVYSPVAFGKKTDKNGDYIRKYLPLLKKFPAEYIYEPWKAPRSIQQAAGCIVGKDYPHPIVQHEVISKKNIQRMKLAYAKRSPESPSKSKGVKRKAPSIEIIKKKAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQR5</accession>
    <name>A0A3P9BQR5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small nuclear ribonucleoprotein U11/U12 subunit 48</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004551148.2">
        <property type="nucleotide sequence ID" value="XM_004551091.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQR5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011961"/>
    <dbReference type="Ensembl" id="ENSMZET00005012370.1">
        <property type="protein sequence ID" value="ENSMZEP00005011961.1"/>
        <property type="gene ID" value="ENSMZEG00005008977.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101483670"/>
    <dbReference type="CTD" id="154007"/>
    <dbReference type="GeneTree" id="ENSGT00940000179251"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051591">
        <property type="entry name" value="UPF0224_FAM112_RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402:SF10">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 48 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="5">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="342" mass="40551" checksum="A966543CC6C15C4B" modified="2019-02-13" version="1">MSDSLPPLTLQDRMERLQELTEFTEKCKKQINDIFETLGWSLDYKNSNQEPMEQCPYDPHHRVPVRTMEKHKASCKLKKMGYSAEEQAEMYDPSVSYENTSVRSFTMDKTTQHQVILQARSAAPMMRMEGVFWQGQYSGEPVDVPQNHKRAVCDLTVADRLALYNHVVGVINEQKEASSSNDDLYVDLVSKLQKGEEQNEPKTKLELMAEMRDYKRRRQSYRAKNVHITKKSYTEVIREVINVHSEELARQWKEEEDEEESMRVEQSSHGRQVDERRSPSSESHHSHSKRHRSRERSHERESKKKKSRRDRDSHSPDDHHHHHDKKKKKKKKKDEKDREKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BR65</accession>
    <name>A0A3P9BR65_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BR65"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012414"/>
    <dbReference type="Ensembl" id="ENSMZET00005012851.1">
        <property type="protein sequence ID" value="ENSMZEP00005012414.1"/>
        <property type="gene ID" value="ENSMZEG00005009338.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282637"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018280110" description="UPAR/Ly6 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="9823" checksum="75278C813C7EC93C" modified="2019-02-13" version="1">MKLLGALILVLSLSAACGLKCYVCAFSDPHSCTDALTCPAGMDRCFSTVTKSCINSVSCVSPMRCCEGNLCNSAIPTGPSVVLLLVSSAIITIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BU07</accession>
    <name>A0A3P9BU07_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GC-rich promoter binding protein 1 like 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vasculin family.</text>
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        <property type="nucleotide sequence ID" value="XM_004567139.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024806049.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024806050.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_024806051.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A3P9BU07"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013116"/>
    <dbReference type="Ensembl" id="ENSMZET00005013565.1">
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        <property type="gene ID" value="ENSMZEG00005009840.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101479019"/>
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    <dbReference type="GeneTree" id="ENSGT00420000029753"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Vasculin_fam"/>
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        <property type="entry name" value="VASCULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14339:SF10">
        <property type="entry name" value="VASCULIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15337">
        <property type="entry name" value="Vasculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010099"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="Ensembl" id="ENSMZEP00005013116.1"/>
        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BV74</accession>
    <name>A0A3P9BV74_9CICH</name>
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        <submittedName>
            <fullName evidence="5">Regulating synaptic membrane exocytosis 3</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Synapse</location>
        </subcellularLocation>
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    <dbReference type="RefSeq" id="XP_004547885.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BV74"/>
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    <dbReference type="Ensembl" id="ENSMZET00005014345.1">
        <property type="protein sequence ID" value="ENSMZEP00005013875.1"/>
        <property type="gene ID" value="ENSMZEG00005010454.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mze:101487626"/>
    <dbReference type="CTD" id="9783"/>
    <dbReference type="GeneTree" id="ENSGT00940000159332"/>
    <dbReference type="OrthoDB" id="420032at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Regulating synaptic membrane exocytosis 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF25">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="172"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="324" mass="34492" checksum="0A3B79FCE8894C25" modified="2019-02-13" version="1">MMLSSSVEVPRPGGMSGLSGLSTAARNVVRSSSISGAMYSLEKSPGSGGPDSASLTGTKKRRSSLGAKMVAIVGLSQWSKSTQQLNQQDGGTKKLRSTIRRSTETGIAVEMRNRVTRQGSKDSTDGSTNSNSSDGTFVFPTTRLGPESQFSDFLDGLGPAQIVGRQTLATPPMGDVNVGMVDRGGQLEVEVNQARGLTPKPGSKNIPATYVKVYLLENGVCLAKKKTKVVKKTLDPTYQQALLFDESPQGKVLQVIVWGDYGRMDHKCFMGMAQILLEDLDLSATVSGWYKLFPTSSLADPSIGPLTRRLSQSSLESATSPSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXS3</accession>
    <name>A0A3P9BXS3_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein OZF</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004540022.1">
        <property type="nucleotide sequence ID" value="XM_004539965.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXS3"/>
    <dbReference type="Ensembl" id="ENSMZET00005015189.1">
        <property type="protein sequence ID" value="ENSMZEP00005014704.1"/>
        <property type="gene ID" value="ENSMZEG00005011072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="106674457"/>
    <dbReference type="KEGG" id="mze:106674457"/>
    <dbReference type="GeneTree" id="ENSGT01150000286959"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000516">
        <property type="entry name" value="zinc finger protein 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001450">
        <property type="entry name" value="zinc finger protein 774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="459" mass="53018" checksum="BE194BD27121EC44" modified="2019-02-13" version="1">MAAVFPADVQQLLVIKEEVLHECSLSLDHHDSEFLHIKEEQEEFWKSQEGEQLSGLEDYISGFPFTAVHVKSEDDDEKPQFSTLHQSQTENSRETEPPASSSAEQIKIGNYSSPDPVRHPHPDTPLQSRTDGEASEFEKTEVSEDDDWQEPLSDCGPEADESNSWLNDSTLTESGVKNDVRCNAAKKFLSCSESGEQFVCKQSLQKHVTCHSEKRSSNCLDNKKICRVEQSVDSQVKRFGCDDCGKRFNQKKELRIHMRVHTGERPFGCTECGKRFRYQGNLKMHTKVHADEKPFGCDDCGQRFSRKTNLTRHMRVHTGEKPFGCDECGQRFNHKANLKLHIRVHTGEKPFSCEDCGQRFYHKTDLKRHMRIHTEEKPFVCDHCGKPFRYRCNLRRHMSVHSGEKRFVCSVCGNTFNREGNLKIHMRVHTGEKPFDCEFCGKSYRHQYSFKTHMKIHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BZI7</accession>
    <name>A0A3P9BZI7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BZI7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015390"/>
    <dbReference type="Ensembl" id="ENSMZET00005015888.1">
        <property type="protein sequence ID" value="ENSMZEP00005015390.1"/>
        <property type="gene ID" value="ENSMZEG00005011564.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271858"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF112">
        <property type="entry name" value="SI:CH211-113E8.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="256" mass="28963" checksum="9DFE382C53642250" modified="2019-02-13" version="1">MEAAGSWTDTLEPSAGEGGGCPDLRIVMIGKTGVGKSAVGNTILGKKHFKSLPSSESVTETCQTGETQLEERKIYVIDTPGILDTGKPAEMIEKEIVRCVEVSSPGSHVFLLVLQVGRFTKEEKNSVKALQALFAPKAQHYMIVLFTHGDDLEDQDITIQKYVRESKPQLRQVIHNCGNRFHVFNNRSKDRKQVEELMKKIDDMVAGNGDTYYTNATFREVEERKQKQPDRESEEYKFLCQLVAQILRFHSRLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0K5</accession>
    <name>A0A3P9C0K5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 24</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ARF6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004571405.1">
        <property type="nucleotide sequence ID" value="XM_004571348.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0K5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015622"/>
    <dbReference type="Ensembl" id="ENSMZET00005016123.1">
        <property type="protein sequence ID" value="ENSMZEP00005015622.1"/>
        <property type="gene ID" value="ENSMZEG00005011724.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005016133.1">
        <property type="protein sequence ID" value="ENSMZEP00005015632.1"/>
        <property type="gene ID" value="ENSMZEG00005011724.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477827"/>
    <dbReference type="KEGG" id="mze:101477827"/>
    <dbReference type="CTD" id="57465"/>
    <dbReference type="GeneTree" id="ENSGT00410000025739"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF122">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN SKYWALKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="TLDc" evidence="11">
        <location>
            <begin position="345"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="460"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="569" mass="63799" checksum="1E2D7CF2B1354FF9" modified="2019-02-13" version="1">MAEEDYGSFVDWNQMGDLAKSSGPTKVDTKDLKEFKRMARQGYWAKNHKLRAQVYQQLIKAIPCRTVTPDAAVYRDIMGNAATKKTSTNVPLPEFVDGNPIPRYCLKPEAVASAHQIINCLAGHFPDISHCPALPAVTSLLLHFSVDEAQCFEHVSRILACNEPGKRLIDQTFLAYESSCMTFGDLANKYCTAAHKLIVATAQDVMDVYSDWQRWVLGDLPFSHVVRVLDVYLVEGYKVLYRVAVALLKFYRKHKMGAEGGQGNQQQEDSNKIKADIQVFVKGIASTVTPDKLLEKAFSIRMFSRKEITLLQLTNEKSLQQKGITVKQKRRNVQLALNPDTFSSEIVSAKEMHDIWSWIPERFALCQPQLLFTTSTHGCSLNRFYSHCEGHEPTLLLIRTTDGDVCGAFLSTDWEERKRGGNKLSFFGTGECFVFRLKPEMERYEWIVISHPELASSIKTQAQKETATSEDQITDSNSLQQPEKPPGELSPFLSARHFNLNSKNTSMFMSGNVDSIIVGGGNGNALYIDSELNHGRTGSCTTFDNPPLCAESFQISLLEVWGFQDTMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C1V9</accession>
    <name>A0A3P9C1V9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C1V9"/>
    <dbReference type="Ensembl" id="ENSMZET00005016377.1">
        <property type="protein sequence ID" value="ENSMZEP00005015866.1"/>
        <property type="gene ID" value="ENSMZEG00005011919.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240400"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13733">
        <property type="entry name" value="SPRY_PRY_C-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000004">
        <property type="entry name" value="Butyrophilin subfamily 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF32">
        <property type="entry name" value="BLOODTHIRSTY-RELATED GENE FAMILY, MEMBER 16 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="10">
        <location>
            <begin position="348"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="247"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="546" mass="62182" checksum="EE19C914860AF4D7" modified="2019-02-13" version="1">MSAASCLLSEDRFLCSICLNVFTDPVSTPCGHNFCKSCICQHWDISERCQCPMCKKVFETRPELHINTFISDMVSQFRHEAQQKVSSSSSEQQAAKPGEVPCDICTGTKLKALKSCLVCLASFCQTHLEPHLTMKGLKRHQLIDPEENLEGRMCMKHDKPLELFCKTDQTCVCMLCSVIDHNTHEFVPLREEYEGKKAELGETEAETQQMIQKRRLKIQEIKESVKMSKDAADRKKAEGVQVFTALKESVDRSLNELIKEIEDKQETTEKQAEGFITDLEQEISELMKRSSEVEQLSRSKDHLHLLQSFSSVKAAPTTKDWTEVSIHPPSYEGTVVRVVGQLKETLDEEIEDLFDAELKRVQQYAVDVTLDPDTAHPKLILSDNGKQVHVDQEENDLPDNPKRFSEFPIVLGKQSFSSGRFYIEVQVKAKTFWMLGVVRESVNRKEEFTFEWTPKKGYWCVFKANENLSLDNLPVHLPLHRPEKVGVFVDYEEGLVSFYDVDHAALIYSFTGCSFTEKLYPFFCPGNNDDGNNSAPLIICPVNQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C323</accession>
    <name>A0A3P9C323_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dysbindin domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dysbindin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004539444.1">
        <property type="nucleotide sequence ID" value="XM_004539387.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012775944.1">
        <property type="nucleotide sequence ID" value="XM_012920490.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C323"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016655"/>
    <dbReference type="Ensembl" id="ENSMZET00005017188.1">
        <property type="protein sequence ID" value="ENSMZEP00005016655.1"/>
        <property type="gene ID" value="ENSMZEG00005012511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471994"/>
    <dbReference type="KEGG" id="mze:101471994"/>
    <dbReference type="CTD" id="79007"/>
    <dbReference type="GeneTree" id="ENSGT00390000018903"/>
    <dbReference type="OrthoDB" id="9891754at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007531">
        <property type="entry name" value="Dysbindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16294:SF4">
        <property type="entry name" value="DYSBINDIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16294">
        <property type="entry name" value="DYSTROBREVIN BINDING PROTEIN 1 DYSBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04440">
        <property type="entry name" value="Dysbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="155" mass="17155" checksum="1B613D4C13D3551D" modified="2019-02-13" version="1">MEAQGGAGSPEPNKDIQKLLKPSSSGDLSKELFQHPLAEEEGSLSGHTASLLHINEKRQPLSSVSSLEVHFDLLDLTELTDMSDQELAEVFADSDEENHNESPAGSHHPALPRGGYMRSPSWTRCSKVEPPRERKHHSDSDTTEPLMKLERPKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C324</accession>
    <name>A0A3P9C324_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_014264259.1">
        <property type="nucleotide sequence ID" value="XM_014408773.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C324"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016286"/>
    <dbReference type="Ensembl" id="ENSMZET00005016805.1">
        <property type="protein sequence ID" value="ENSMZEP00005016286.1"/>
        <property type="gene ID" value="ENSMZEG00005012234.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101465414"/>
    <dbReference type="KEGG" id="mze:101465414"/>
    <dbReference type="CTD" id="553724"/>
    <dbReference type="GeneTree" id="ENSGT00390000018525"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF1">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="162" mass="17805" checksum="2F803F7FDD584B97" modified="2019-02-13" version="1">MDKLKKVLSGQDDGNADGSGILERANQASTLSWGTRVKGFLICFVLGVVCSILGTCLLWVPGFGLAVFAVLYSLGNICALSSTMFLMGPCRQLKTMWAKERVLATVIMLVCLVLTLCAAFWWKNNGLALLFCILQFLAFTWYGLSYIPFARDAIIKLFSLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C3I9</accession>
    <name>A0A3P9C3I9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Neutral cholesterol ester hydrolase 1</fullName>
            <ecNumber evidence="16">3.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Acetylalkylglycerol acetylhydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Arylacetamide deacetylase-like 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="27 28">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38563"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:34115"/>
            <dbReference type="ChEBI" id="CHEBI:75936"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1-O-alkyl-2-acetyl-sn-glycerol + H2O = a 1-O-alkyl-sn-glycerol + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15850"/>
            <dbReference type="ChEBI" id="CHEBI:16291"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.71"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:11553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36403"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17002"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:36404"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:46898"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:33876"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.71" evidence="16"/>
    <dbReference type="RefSeq" id="XP_004540221.2">
        <property type="nucleotide sequence ID" value="XM_004540164.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C3I9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005016833"/>
    <dbReference type="Ensembl" id="ENSMZET00005017371.1">
        <property type="protein sequence ID" value="ENSMZEP00005016833.1"/>
        <property type="gene ID" value="ENSMZEG00005012650.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101479278"/>
    <dbReference type="GeneTree" id="ENSGT00940000156699"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047378">
        <property type="term" value="F:acetylalkylglycerol acetylhydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF29">
        <property type="entry name" value="NEUTRAL CHOLESTEROL ESTER HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="25" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017941323" description="Neutral cholesterol ester hydrolase 1" evidence="25">
        <location>
            <begin position="18"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="26">
        <location>
            <begin position="119"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="26">
        <location>
            <begin position="330"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="23 24">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="23">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="23">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005016833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="419" mass="46974" checksum="B5ECBC8D2CC081EC" modified="2019-02-13" version="1">MRLLSLLLTVSLTLALAYYIYIPLPDAIQQPWKLMILDAYLRTAFHVASLKQWLGFDHQTRSFRQFTFGFEGILKEFLSTESSAGAVPGVKVSDISFAGIPVRVYEPPAGGEGHLRRGLMYFHGGGWALGTTKKGPYDIINRMVSDELNTVVVSVEYRLYPDVHFPVPYLDCIAAAKHFLSPEVLAKYSIDPDRVAVAGDSAGGNLAAAVAQEISVDDSMSVKFSVQALIYPVLQALDFNTPSYLQNQYIPVLYRTSMIQFWLQYLNIDLSLMPEFLVNNHSALQHSSLTPELRSRLDWNVLLTQKYKKNYKPVIVEKGSEGFLKRVPGLLDVRAVPLLAGPEVLAKCPRAYILTCEHDVLRDDGLMYVRRLQDAGVAVTSDHYEDGFHGCFSLTSWPLEFDVGKKALRGYLSWLQNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C423</accession>
    <name>A0A3P9C423_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G2/mitotic-specific cyclin-B2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for the control of the cell cycle at the G2/M (mitosis) transition.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547001.1">
        <property type="nucleotide sequence ID" value="XM_004546944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C423"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005017018"/>
    <dbReference type="Ensembl" id="ENSMZET00005017562.1">
        <property type="protein sequence ID" value="ENSMZEP00005017018.1"/>
        <property type="gene ID" value="ENSMZEG00005012782.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478181"/>
    <dbReference type="KEGG" id="mze:101478181"/>
    <dbReference type="CTD" id="10309"/>
    <dbReference type="GeneTree" id="ENSGT00940000155998"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0195">Cyclin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="10">
        <location>
            <begin position="125"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="151"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="286" mass="32268" checksum="587471FABA1DA1D7" modified="2019-02-13" version="1">MIQREKEAQFHPCKSLARQPQLTAEARCKLVSWLIPVHKHFRLSFECCCLAVNIMDRFLASTPVAADCFQLIGVTALLLASKQVEVCSPRISHLLSLCCDVFTKEQLCNLECLILLRLNFRLSAPTLAFFLDYYTNCIEASQLVTRNKGDDRISRMNPDPKIPRQCSNLAQNVCELTLADYAFNKYPPSLTASCALRVASELLKSKQGLPEHETIHSHEVQWDSFVDELCTQSVSFQPTGNSKHYEGDSLAVKDDSYKQSLVQECKDNLKLLVSLNLETLDVMSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4S8</accession>
    <name>A0A3P9C4S8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4S8"/>
    <dbReference type="Ensembl" id="ENSMZET00005017653.1">
        <property type="protein sequence ID" value="ENSMZEP00005017107.1"/>
        <property type="gene ID" value="ENSMZEG00005012852.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286911"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051261">
        <property type="entry name" value="NLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24106">
        <property type="entry name" value="NACHT, LRR AND CARD DOMAINS-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018037154" evidence="3">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="149" mass="16391" checksum="F0FCF9F15CDD9AA2" modified="2019-02-13" version="1">MNIWPNTLFMFVVFLLSVSRCGITGAGCRYLAKVLCSISQLTDDLDLSMNHIGDKGVKEISPGLMNPLSHLKTLNLSYCSLTDSCCAELASGLMSKANILSELDLSHNNLQDKGVKKLYIGLQSPQCKLEKLALAELTKNHKYALRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C4Z3</accession>
    <name>A0A3P9C4Z3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C4Z3"/>
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        <property type="protein sequence ID" value="ENSMZEP00005017348.1"/>
        <property type="gene ID" value="ENSMZEG00005013041.1"/>
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        <property type="component" value="LG23"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="NLRP_HD2"/>
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        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="WHD_NOD2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
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    <dbReference type="SUPFAM" id="SSF52047">
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="78"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="788" mass="88789" checksum="0D8E169D54875EB2" modified="2025-10-08" version="2">MKKKFQCVFEGIAKAGNPTLLNQIYTELYITEGGTAEVNDEHEIRQIETVSRKSKGPETTIRQEDIFKSSLGRDEPIRTVLTKGVAGIGKTVLTQKFTLDWAEDKANQEIQFIFPFTFRELNVLKEEKFSLVELVHHFFTKTKESGICRLEDFQVVFILDGLDECRLSLDFNKTKILTETRKSTSLDVLLTNLIKGNLLPSARLWITTRPASASQIPPECVDLVTEVRGFTDPQKEEYFRKRFRDEEQTSRIISHIKTSRSLHIMCHIPVFCWITATVLEDVLKTTEGGELPKNLTEMYIHFLVVQAKVKRIKYDGGTETDPHWSPESRKMIESLGKLAFDQLQKGNLIFYESDLTECGIDIRTASVYSGVFTQIFKEERGLYQDKVFCFVHLSVQEFLAALHVHLTFINSGVNQLEEQQTSSQTENDFYQSSVDKALQSPNGHLDLFLRFLLGLKTNKICLQGLVTQTGSSLQTNRETVQYIKNKLSENLSVEKNINLFQCLNELNDRSLVEEIQQSLSSGSLSTDKLSPAQWSALVFILLSSEKDLDVFDLKKYSASEEALLRLLPVVKASKKALLNSCNLSERACEALSSSLQLEDCELRALDLSNNNVQDSGLTILFSGLKTTNWKLETLRSDIVDLGVSATLKGLKDSKAISWEGVSNSFFISCQTLSSLLSSQPSSLRELDLSNNDLKDSGVKVLSSGLESLCCKLETLRLSGCLITEEGCKSLVSAFSLNSSHLKELDLSYNNPGEAVVKMLEQLRLDTLRYVDGRYNHKHCLIDEETDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C699</accession>
    <name>A0A3P9C699_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synaptogyrin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the synaptogyrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004559478.1">
        <property type="nucleotide sequence ID" value="XM_004559421.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C699"/>
    <dbReference type="Ensembl" id="ENSMZET00005017973.1">
        <property type="protein sequence ID" value="ENSMZEP00005017421.1"/>
        <property type="gene ID" value="ENSMZEG00005013107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101466363"/>
    <dbReference type="KEGG" id="mze:101466363"/>
    <dbReference type="CTD" id="563028"/>
    <dbReference type="GeneTree" id="ENSGT00950000182935"/>
    <dbReference type="OrthoDB" id="10041611at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF19">
        <property type="entry name" value="SYNAPTOGYRIN-2 LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011282">
        <property type="entry name" value="Synaptogyrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="224" mass="24915" checksum="1B819D2F707ADFB2" modified="2019-02-13" version="1">MQNSAYGASLAGGAFDLANFLKQPQTILRFLSWIFSIVVFATITAEGYTNTTEKAENECMFHNSDSACSYGVGVGVLAFLACVLFLMLDAYFPNISNAKDRKYIVISDLAFSAVWTFLWFICFCVLTSLWSKTTNEQVVADAARGVIAFSFFSIITWSLLTYFALARYRQGVNEFEQEYRDPANDHNAPYQSSPYSSTSGPSGYQQSPFSNTQETPGAYQPPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C6M4</accession>
    <name>A0A3P9C6M4_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized LOC101470615</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_014262986.2">
        <property type="nucleotide sequence ID" value="XM_014407500.2"/>
    </dbReference>
    <dbReference type="STRING" id="106582.ENSMZEP00005017709"/>
    <dbReference type="Ensembl" id="ENSMZET00005018275.1">
        <property type="protein sequence ID" value="ENSMZEP00005017709.1"/>
        <property type="gene ID" value="ENSMZEG00005013317.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101470615"/>
    <dbReference type="CTD" id="569303"/>
    <dbReference type="GeneTree" id="ENSGT01140000282610"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014850">
        <property type="term" value="P:response to muscle activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043442">
        <property type="entry name" value="Perm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47282">
        <property type="entry name" value="PGC-1 AND ERR-INDUCED REGULATOR IN MUSCLE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47282:SF1">
        <property type="entry name" value="PGC-1 AND ERR-INDUCED REGULATOR IN MUSCLE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005017709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1298" mass="142410" checksum="8E1036ED382900E2" modified="2019-02-13" version="1">MEEFEYSVEICDRDWERFFAECEECNLLPPSLAGLEDSGMSDIDDTGSVLAMRAQRVDLTAGFSETDRPIDGPPHCEGSPVEHYLSKHGIGGMESVLSGSEEDIHLQSVNMFFERLKSLTEPEPSRVNFGKNSEAIQETERCSEGQQASRDALPKNIQKLNFLPARGETAVGKESKRPVDTIRKTNTLRKVHSDPSISLQHAASNSVLNTNKSTETELFIREEACTEPRVSDVQQWNRDSLCTAVCSVTTPNKVQTCALLHDFKEEELLKHLCKKCATDLASDLDMANIKWQEDQTPIVSQSDTACSNKAVIQESPSASMKRKRRKKRRLSVEQGEGGHGYERQVLVKPSDSEEEQCPSKAGTGLCFSEDIKSFYLNEPQKNLTSLLTPYSMTSSSFPVIISSNPPCDSQHQYLSESVGRQRRSTDTSDNNSANNSSATTLSQTDDSATSAPNSSATVATNSEVCSESQEEKSAGLKMYPKLSVLMTVGEYGKPDMGRESQSGDIKVEGRHSVTSPENEQNLTSAVEVKAVTHSLLSSSESNATSVEVGQNDRQPAAKSVLAVEAGNSGGDEPTLCPSEAEPQQQLEKEFHNTDQYSGTMANTDYSPPTASTLKGLLTKPLQLKTSACKVISAQFTSDSFNPSPDESFLSKSSPCIGVNTECPLEVHTSPKLDISEKSTETLAASQITSKSRAETKSPVSEDALTSLSDITNVSSCGTLNTESRSNGNIRDMPASFCSSVSEQESGGHGGKKGDEKSGLKSSDSVCELLGKAEDAILVPEAECKPERVLNPVFAMSSFWSEMEKLTINDILGLRMISKAAPPSSLPPLQEKEEMADSGFFTQIDESTPEQTTEDASGFPDAVESCFNPNSAANFSPSRSVLWESESAHVSRSADIYPENVMLTSVSDTSRPFLSEKAEKSLRKISKNISVHNLRALESESFSYTQKCETLQTVDEGESQKAEYVLPKQDKGTDPLPSSLTDSYSISLIDIFQYFFGGKQTAPSQPAADNLTTFYDDGNSVPETYDHFFSEFDTENFFYPLIATEDETKDKPVPIFSSSRSANRKFQFPEAYDYFFASSSSSDESESDEEDNTGPVRVFTRFSRKASSSHISKDMYDDFFAENNLRQNFFWKTTFSFRNINFSASTVQNQASHSLSLVPARQRGGSHARTVSSLNALGNEDVMFPDPLLYHFEDRVVSQLAQQPFRYEDLQTAVSNPRLDAPFLPLKQSDMCLVCIAFASWVLKTANPQVGDAWKAVLLANVSALSAIRYLRKYVKAEAAGCETKLHRRALPAPSPLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C7V6</accession>
    <name>A0A3P9C7V6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">55 kDa erythrocyte membrane protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Membrane protein, palmitoylated 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004557384.2">
        <property type="nucleotide sequence ID" value="XM_004557327.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C7V6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018355"/>
    <dbReference type="Ensembl" id="ENSMZET00005018947.1">
        <property type="protein sequence ID" value="ENSMZEP00005018355.1"/>
        <property type="gene ID" value="ENSMZEG00005013784.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101473723"/>
    <dbReference type="CTD" id="4354"/>
    <dbReference type="GeneTree" id="ENSGT00940000158744"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10830">
        <property type="entry name" value="PDZ_MPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12080">
        <property type="entry name" value="SH3_MPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035475">
        <property type="entry name" value="MPP1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="169"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="11">
        <location>
            <begin position="292"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="476" mass="53743" checksum="9838CD17DFC57D0F" modified="2019-02-13" version="1">MFFFYLTGKMTLKSNKNDPTVTLESVNSVRTALSDLYLEQLLQNKPKSDKAAMQNFENQGADFYTNGSAGHRNCTEVPRMKEVAFEKSASEPMGVTLKLNEKQRCTVARILHGGMIHRQGSIHEGDEIAEINGKTVTNQTVDQLQKILRETNGVVTMKIIPNMKSRSRICEMYMRAQFNYDPATDDLIPCKEAGLKFQTGDIIQIINKQDPNWWQGRVESSATDFAGLIPSPELQEWRVASKSKAKEGTQSCSPFGKKKKCKDKYLAKHSSIFDQLDVISYEEVVRLPAFQRKTLVLIGAPGVGRSHIKNALLTRYPEKFSYPSPHTTRPQRKDEENGKEYYFISHEAMTKSISGNELLEYGSFQGFMFGTKIETIQKIHTQGKIALLDIEPQTLKLLRTADFAPLVVFIAPTNTAPQTENLQMIQKESDAILSTYGHFFDVVLINNDVDESVKGVEEAMERATSTPQWVPVSWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9I2</accession>
    <name>A0A3P9C9I2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9I2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005018757"/>
    <dbReference type="Ensembl" id="ENSMZET00005019359.1">
        <property type="protein sequence ID" value="ENSMZEP00005018757.1"/>
        <property type="gene ID" value="ENSMZEG00005014068.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164876"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008499">
        <property type="term" value="F:N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF115">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005018757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="371" mass="43122" checksum="35CEC9161BDC75EE" modified="2019-02-13" version="1">MAKKGDITHHFYLSCLFRELVQSIFPQKKILFHSWFQLLLLFCVLALGLCYTLSSRPLSLWQSFPLQEQYQWFLNQNSRVNAPAYRIHPKNKVILNKTTEPSTVRSTSLQYHQAYPRNYHFLMDNTEVCKNKIPFLVLMVPVEPKNVAARDVQGEVVLTLFMLGVSREDDVEKLKQENLQHHDLIQSDFTDSYLNLTIKTMVIMDWLSTHCPAAAYAMKIDSDMFLNVDNLVIMLKQPGIPKTNYLTGMLMWNRPVIRSKNSKWYVPEELYPEPEYPTYTLGMGYVFSNDLPEKYVEMSKSVKPFNIEDAYIGMCMKKLGLALTAPPTPSQFKAYNYAYNRCEFSKVITYILGSSKQCHRLLRGTTCRTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C9W2</accession>
    <name>A0A3P9C9W2_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase 2, cytoplasmic</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004562588.1">
        <property type="nucleotide sequence ID" value="XM_004562531.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9C9W2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019073"/>
    <dbReference type="Ensembl" id="ENSMZET00005019686.1">
        <property type="protein sequence ID" value="ENSMZEP00005019073.1"/>
        <property type="gene ID" value="ENSMZEG00005014310.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483599"/>
    <dbReference type="KEGG" id="mze:101483599"/>
    <dbReference type="CTD" id="2053"/>
    <dbReference type="GeneTree" id="ENSGT00940000158614"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000067">
        <property type="entry name" value="Bifunctional epoxide hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="258"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="561" mass="61800" checksum="1762785FC4AC92FD" modified="2019-02-13" version="1">MADKKAILFNFWGVAVSARRAAIFKKLEELHNLPGGFLSSLESKDDGALRQAERGAMTLTQMIPALEAECVQEARDRSVTLPADWSVKGLLDKLTEAMMDVQAAVLKTAAGLRRSGLLTAVLANHWVDDRAAGDGTGRLLSLLGGHFDLVLQSCHLGHRVPEPAMFSSALQRLGVTPKQALWLDADVEGVKAAEGAGMKAVLVENLDAALEKLSEFTGFQAVGTVSPPPACSPDEVSHGYITIKPGVRTHYVEMGSGPPVLLCHGFPESWYSWRYQIPALAAAGFRVLALDMKGYGESTAPPDIEEYSHEELCKELVVFLDKMSIPQVTLVGHDWGGSLVWAMARFYPERIRAVASLNTPMFKLNPLVPAFERLKAIPIFDYQVYFQTPGVAEAELEKDLERTFKIFFSSSSEAKGRPPLSTAGVCARGGLFVGLPEQIPRSSMLTEADLQYYASQYKERGFRGPLNWYRNSDANWKWMCSRPFEKLLMPTMMLTAGKDPVLLPSFTKGMEDSMPNLTRGHIEECGHWTQMEKPAETNKILISWLKEAHKKTEGGTVAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CAL5</accession>
    <name>A0A3P9CAL5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="15">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:27607"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="15"/>
    <dbReference type="RefSeq" id="XP_004541513.1">
        <property type="nucleotide sequence ID" value="XM_004541456.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CAL5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019330"/>
    <dbReference type="Ensembl" id="ENSMZET00005019956.1">
        <property type="protein sequence ID" value="ENSMZEP00005019330.1"/>
        <property type="gene ID" value="ENSMZEG00005014508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478540"/>
    <dbReference type="KEGG" id="mze:101478540"/>
    <dbReference type="CTD" id="393931"/>
    <dbReference type="GeneTree" id="ENSGT00530000063576"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF32">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 15" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="437"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="468" mass="54680" checksum="19524DD2E21B8E32" modified="2019-02-13" version="1">MAAVYSGSHTLSKDDVNYRMHFRMINEQQVEDITIEFFYKPHTITLLTCTVLSLMYFAFTRDDGNPDNNLWVGVILVISFFLVISVLAFPNGPFTRPHPAIWRIVFGLSVLYFLFLVFIIFLNWQQVKQLMYWLDPNLRYAKREADIMEYAVNCHVITWERILSHFDIFAFSHFWGWGMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMTVCRFLEMRTYHWASIKDIHTTTGKIKRAVLQFTPASWTYVRWLDPKSSLQRVTGVYLFMIIWQLTELNTFFLKHIFVFPASHALSWCRILFIGIITAPTVRQYYAYLTDTQCKRVGTQCWVFGAIAFLEALACIKFGQDLFSKTQILYVILWLLCLAFITFLCLYGMVWYAETYGPREKSLSECEDSNFAEFADHVYEGFKGETDVDGDSPKARQRKKDSGKTKSINGLDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CBM0</accession>
    <name>A0A3P9CBM0_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CBM0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019683"/>
    <dbReference type="Ensembl" id="ENSMZET00005020313.1">
        <property type="protein sequence ID" value="ENSMZEP00005019683.1"/>
        <property type="gene ID" value="ENSMZEG00005014776.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234576"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000275">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="178" mass="20692" checksum="BB295A28270E4599" modified="2019-02-13" version="1">IEPEPKRDHLNCVSSDVTVREYQGAGKKGHNNVEYQPTPDSQCKSDKTKKSLKCDVCGEVYKYNYEMDMHYRIHTGGKPFSCKTCGKKFVHRNSVVKHMRIHTGEKLYHCKICGKRFVHRSLKKHMRMHTGEKPYHCKTCGKTFSRKTSCVERKVEQVSVVTNGRHSMVGRRLWLVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CCL1</accession>
    <name>A0A3P9CCL1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclin B1</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for the control of the cell cycle at the G2/M (mitosis) transition.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CCL1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005019616"/>
    <dbReference type="Ensembl" id="ENSMZET00005020245.1">
        <property type="protein sequence ID" value="ENSMZEP00005019616.1"/>
        <property type="gene ID" value="ENSMZEG00005014722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154586"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000198">
        <property type="entry name" value="G2/mitotic-specific cyclin-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 8" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="174"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="11">
        <location>
            <begin position="267"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="271"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="373" mass="42111" checksum="2FDA99C001848A77" modified="2019-02-13" version="1">MALRVTRNRLASTKVDLGGKACSVSGPTQKPRAALGEIGNIAVNKDAQKKTVKTEALKTKVTTRAEKAEQTKQKDVIPVKPEPEVQAPPEPASPTPMETSGCEPADLCQAFSDVILHTAIRDVDADDYDNPMLCSEYVKDIYKYLRQLEVEQNVRQNYLQGQEVTGNMRAILIDWLVQVNLKFRLLQETMYMTVGIIDRFLQDNPVPKKQLQLVGVTAMFLASKYEEMYPPEISDFAYVTDKAYTTAQIRDMEMTILRVLKFQLGRPLPLQFLRRASKIYEVTAEQHTLAKYLLELTMVDYEMVHLPPSMVASAALALTLKILAAGEWDVTLQHYMDYTAESLIPVMAHIAKNVVKVNNGLTKHMVSFLYFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDA5</accession>
    <name>A0A3P9CDA5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDA5"/>
    <dbReference type="Ensembl" id="ENSMZET00005020495.1">
        <property type="protein sequence ID" value="ENSMZEP00005019851.1"/>
        <property type="gene ID" value="ENSMZEG00005014908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263473"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 20 MEMBER A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45784:SF3">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER K-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018155517" description="C-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="58"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005019851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="171" mass="19646" checksum="469A44CB07AD9A1A" modified="2019-02-13" version="1">CVHYVLFCFLCLFVLLLSCVCVCVCVCVCVCVKCFNCEFCGNEKSVKLILFYFAATKQGADQYILNTQNMVWTAARDYCRTHYTDLTSLRNDAEYQIVQQVANGNEVYVGLFRDPWEWSDQTDSSFRYWNPDKTVWTDGTQNCVAMLKVNSGKWGDRACTETHPFVCDCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CDZ4</accession>
    <name>A0A3P9CDZ4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transportin-3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with (GTP-bound) Ran. Interacts with (phosphorylated) SFRS1 and SFRS2; leading to their nuclear import. Interacts with NUP62. Interacts with RBM4. Interacts with CPSF6, promoting its nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004565006.1">
        <property type="nucleotide sequence ID" value="XM_004564949.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CDZ4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020116"/>
    <dbReference type="Ensembl" id="ENSMZET00005020763.1">
        <property type="protein sequence ID" value="ENSMZEP00005020116.1"/>
        <property type="gene ID" value="ENSMZEG00005015084.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473952"/>
    <dbReference type="KEGG" id="mze:101473952"/>
    <dbReference type="CTD" id="23534"/>
    <dbReference type="GeneTree" id="ENSGT00530000063347"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033077">
        <property type="term" value="P:T cell differentiation in thymus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000079">
        <property type="entry name" value="transportin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF42">
        <property type="entry name" value="TRANSPORTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="13">
        <location>
            <begin position="102"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="923" mass="104099" checksum="12D73137E0C0C5CC" modified="2019-02-13" version="1">MEGGKPSLALVYQAVQALYHDPDPAGKERASLWLGELQRSMYAWEVSDQLLQLKQDVESCYFAAQTMKMKIQTSFYELPPETHNALRDSLLTHIQNLKDLSPIIVTQLALAIADLALQMASWKGCVHTLIEKYNNDISSMLFLIEILTVLPEEVHSRSLRIGANRRTEIIEDLAYYSSTVVTLLTTCVEKTGNDEKMLIKVFRCLGSWFNLGVLDSNFMASNQLLMVLFQVLQRDETSTNLHEASSDCVCSALYAIENVETNVALALQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLETTVRSPGQGMGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKINDPTLHAIFRPYIQRLLHCLARHCQLDPDHEGIPEDTDDFGEFRMRVSDLVKDVIFLVGSVECFAQLYSTLKDGNPPWEVTEAVLFIMASIAKSVDPENNPTLTEVLQQIVLLPESVHMAVRYTSIELVGEMSEVVDRNPRFLDSVLNYLMKGLREKPLASAAAKAIHNICSVCRDHMAQHFHGLLDIARSLDSFALSTEAAVGLLKGTALVLARLPLEKIAECLSDLCAVQVIALKKLLTEQSTNGKSADPTVWLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNTHQADNRIVERCCRCLRFAVRCVGKGSASLLQPLVTQMVGVYQVYPHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCMPTFQLLEQPNGLRNHPDTVDDLFRLATRFVQRSPVTLLSSSIIIHIIQCAIAATSLDHRDANCSVMKFVRDLIHTGVANDHEEDFEVRKRLIGQAMEQHGQQLVTQLMHSCCFCLPPYTLPDVAEVLWEIMVFDRPTFCRWLESALKGLPKETSGGAVTVTHKQLTDFHKQVTSAEECKQVCWAIREFTRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CEZ6</accession>
    <name>A0A3P9CEZ6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase Sgk1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Serum/glucocorticoid-regulated kinase 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_012772030.1">
        <property type="nucleotide sequence ID" value="XM_012916576.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CEZ6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020840"/>
    <dbReference type="Ensembl" id="ENSMZET00005021524.1">
        <property type="protein sequence ID" value="ENSMZEP00005020840.1"/>
        <property type="gene ID" value="ENSMZEG00005015609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484635"/>
    <dbReference type="CTD" id="6446"/>
    <dbReference type="GeneTree" id="ENSGT00940000155726"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05575">
        <property type="entry name" value="STKc_SGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000065">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000030">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="98"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="356"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="431" mass="48808" checksum="6B792CAFE2D6BFF9" modified="2019-02-13" version="1">MTIITETQEPVLTYSKSRGLVALVTAFMKQRRMGLNDFIQRLATNSYACKHSEVQSILNLSPPQDPELMNTNPSPPPSPSQQINLGPSSNPSAKPSDFHFLKVIGKGSFGKVLLARHRTDDNFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHYSFQTADKLYFILDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIILTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNISNSARHLLEGLLQKDRTKRLGCSDDFIEIKNHIFFTPINWDDLNAKKITPPFNPNVTGPNDLRHFDPEFTDEPVPSSIGCSPDSALVTASIKEAAEAFVGFSYAPSMDSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF27</accession>
    <name>A0A3P9CF27_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">von Willebrand factor D and EGF domains</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CF27"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020639"/>
    <dbReference type="Ensembl" id="ENSMZET00005021319.1">
        <property type="protein sequence ID" value="ENSMZEP00005020639.1"/>
        <property type="gene ID" value="ENSMZEG00005015481.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160835"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000031">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000499">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000490">
        <property type="entry name" value="von Willebrand factor D and EGF domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000595">
        <property type="entry name" value="von Willebrand factor D and EGF domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000831">
        <property type="entry name" value="von Willebrand factor D and EGF domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058727">
        <property type="entry name" value="Helical_Vwde"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF53">
        <property type="entry name" value="VON WILLEBRAND FACTOR D AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF26129">
        <property type="entry name" value="Vwde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="VWFD" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="579"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="755"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="788"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="851"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="759"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="777"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020639.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="886" mass="96843" checksum="06D65A693EB20AC1" modified="2019-02-13" version="1">MSLTLRAPISDWRHTEGLCGTYDGQSENDFHLAGGAKLEDLHAFISEWRLPPGNSLFDTVPSHISTLNSRRHCTCQEEMPRFSSPRAPSQPTSSSDPSCSNHGNMHFPSVVPTLDVTAEYITSVELLSENEREPLPSRASRVSTSAYQQPRGRRSAQRFISNSPHQSLSQSDLEGVTYFFPEDHEPAVQPESPLTWPTPSGLTEQQAQAQCRQTVANSSIVMGCRHLLKELFVNHAVTMCVTDLQLKDEQSWLNATIPLLENECERRLLEEGEGEEKYQDAVAILKCPNLCNGNGQCSNWGCVCFPGFSSYDCSALSDQIPEITTLQKDGLCDVRQGNCTTVNIHGQGFKDSYELKCEFVKEKFVDGEWVLDEPLFVLATFLNDTALECQLPLEDSWVSAGVDLETVTNRPLARWQIKVSNDGYSYSNAKILTLYDGACQMCSLRTEVVCTLREKTCNIDGLCYNEGESLPSSPCLACRPDSSKHTWSIAENNEPPLLQSLTLPLQSFEGENFIYQLNARDPEGSTVLFTLLSGPEGASLSPAGLLMWKATAEPTNRHTFQFTVTDDCNAETRASVEVFVRSCECLNAASCVASVNLPAGSGEYVCVCPDGFTGRRCEVDIDNCKPNPCRLGFCIDGLNSFSCVCPPGMTGQLGQSPVEQTVIFTSPDQIPLPPQTDDLLTGERDQKQQISGDFLLYPCGQNMECTLPNTCTCKDGYTGYSCHIAICRPDCKNRGKCVKPNVCKCPAGYGGPTCEEASCEPPCQHGGTCLARNLCTCSYGYVGPRCEIMVCNRHCENGGVCVSPDVCKCQPGWYGPTCNSALCKPVCLNGGTCVKPNVCACPSGFFGSQCQIAVCNPPCKNGGQCMRNNVCSCPEGYTGKRCNIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF51</accession>
    <name>A0A3P9CF51_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ephrin RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CF51"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005020491"/>
    <dbReference type="Ensembl" id="ENSMZET00005021147.1">
        <property type="protein sequence ID" value="ENSMZEP00005020491.1"/>
        <property type="gene ID" value="ENSMZEG00005015365.1"/>
    </dbReference>
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        <property type="component" value="LG11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046875">
        <property type="term" value="F:ephrin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031328">
        <property type="entry name" value="Ephrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001799">
        <property type="entry name" value="Ephrin_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304">
        <property type="entry name" value="EPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11304:SF42">
        <property type="entry name" value="EPHRIN-A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00812">
        <property type="entry name" value="Ephrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ephrin RBD" evidence="6">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="136" mass="15305" checksum="2D69D57F066D44C2" modified="2019-02-13" version="1">MYQSLIATCSINAVVVLPSRLTAGDLSVQLNFNDYLDIHCPHYPNEEAVVTGSRRPLGGSCASEKIQRFTPFSLGFEFLPGRHYYYSLMNPNLKFKLSPVCTEEVRRDAQHECLQPSVKEICAHNVYKPQAIEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CF81</accession>
    <name>A0A3P9CF81_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Olfactomedin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <dbReference type="AlphaFoldDB" id="A0A3P9CF81"/>
    <dbReference type="Ensembl" id="ENSMZET00005021635.1">
        <property type="protein sequence ID" value="ENSMZEP00005020948.1"/>
        <property type="gene ID" value="ENSMZEG00005015723.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000165415"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
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    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
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        <property type="entry name" value="OLFACTOMEDIN-4-LIKE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="OLF"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="104"/>
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        <location>
            <begin position="125"/>
            <end position="384"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005020948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="385" mass="44296" checksum="0DF2EC2636082BF9" modified="2019-02-13" version="1">IPNTTKCDVLLISLENTFKFQAPPREKCACELNNSEKAFPHEKLRIVETNVSDCNSNITPQKVTSLLKLSCCVSPFLLNHCCLCRLLFFFFYVFVCLFLFWWQWESVLRGLEQLIILFIFIPSGTCQRSRLLNVTGPRVYTAGEYPGSYAYGAWGRDPRPEEGKESWYWLVMMTSSNRYSNYVRFYSMALTFGNVQIHSSNPTTNTIQGPNNVLYGGALYYNCYNQDYVCRFNLTTKSVTTLQLPKETFTECYPYTDLDLATDESGVWVVYTTTQDFGNLVLSKLEEGETPVLGKTWRTSVYKQSVTNTFIACGVLYATRYINREVEEIFYSFNTVTGQERFNIGIFMNKMSTNIQSLNYSPVDQMLHAYCDSNMVSYKVNSFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CFS4</accession>
    <name>A0A3P9CFS4_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">Aryl hydrocarbon receptor</fullName>
        </recommendedName>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
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    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="nucleotide sequence ID" value="XM_004563317.4"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005020874"/>
    <dbReference type="Ensembl" id="ENSMZET00005021560.1">
        <property type="protein sequence ID" value="ENSMZEP00005020874.1"/>
        <property type="gene ID" value="ENSMZEG00005015665.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154486"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
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    <dbReference type="GO" id="GO:0034751">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:nuclear receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1904613">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19696">
        <property type="entry name" value="bHLH-PAS_AhR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000035">
        <property type="entry name" value="Aryl hydrocarbon receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000019">
        <property type="entry name" value="Aryl hydrocarbon receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000024">
        <property type="entry name" value="Aryl hydrocarbon receptor 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AHR/AHRR"/>
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        <property type="entry name" value="bHLH_dom"/>
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    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
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    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF17">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00010">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00989">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF14598">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
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    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-0090">Biological rhythms</keyword>
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    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="5" id="KW-0678">Repressor</keyword>
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    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="16">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="15">
        <location>
            <begin position="144"/>
            <end position="207"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="958" mass="105449" checksum="2689E10B42408FEF" modified="2019-02-13" version="1">MLPNTALYAAKKRKKPVQKMPKPPPPEGAKSNPSKRHRDRLNGELDKLTSLLPFTEEVRSRLDKLSVLRLSVGYLKVKGYFNATMKMGQNNNSSYSSERSIMFGGNSASSALQPSSATSTAPSSFTTSTVTSIDGVNFSEGDLLLQALSGFVLVVTAEGYVFYTSPTIQDFLGFHQSDVVHQSVFELIHTDDRAFFRQQLHFSFNPNTEGAEGPSDQSNPEISRNIVSYDPHAVPPENSSFLERNFCCRLRCLLDNSSGFLALNFHGRLKFLHNQNHVSEDGSLVPPQLALFAIATPMQQPSILEIRTKTLMFQTKHKMDFTPIGVDARAKLVLGYSEIEISRKGSGYNFIHAADMLYCAENHVRMMKTGESGITIFRLLTKAGRWVWVQANARLIIKNGKPEFIVAQQRALTNEEGEEQLHLRRLQVPFNYATGEALLYDVTPNIEPRDPCSAPKQGKFDSDAISRESLLGCMLNQDHTLYCDQNSANTLSNLNDMVFKDTNATLNVPGDTEPSPAVGNVVKAETTVQEIMESLQQIFGDGELIESLHVEPDELKSWESTLLQMSCHGGFGDDLSDILNNDILSYVEEQLQKDVGLNLPQQIDGIPACLSGLDPLQNQDPDQGGELDFDWALETQTQLIPNGVQMTAAQETMKLSHMDFPQPNSSGPNGLTFNNVLPNSFPQTQSQLKASSMDNNLGAFPLRQPSTNPGLLQMIPANQTFGLQDQNKEGQLNNVFTFQGTKCSKSVTHQADSCGETFASNISNKAVFSSSLSCMQSHFPVQTPNGNSQRQAWPQQQQLITGQQMGSFQRNPTDIGSLNKFMTPETSNPLPVQQLLERSPASTSCMYRNAAPGLPVNGVHHSQPRLNPAPSQIPSNPSCFYQVGGRAISGMASIPNLDEASLSCQMPTGLKPNGLLGQQKQYLNFSEQTQMNNRPVVGNGVFPFPSLPNGNMCYSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CG76</accession>
    <name>A0A3P9CG76_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NDRG family member 4</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CG76"/>
    <dbReference type="Ensembl" id="ENSMZET00005021723.1">
        <property type="protein sequence ID" value="ENSMZEP00005021034.1"/>
        <property type="gene ID" value="ENSMZEG00005015775.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182872"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060038">
        <property type="term" value="P:cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045162">
        <property type="term" value="P:clustering of voltage-gated sodium channels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000009">
        <property type="entry name" value="NDRG family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="424" mass="46588" checksum="6BCF1B5347781E91" modified="2019-02-13" version="1">MAGMKEQQFTEEKPLLPEQRGVDSDMQDKGEEASGGLQGPTAPAPLNNPPPPSRSTHRWHVFARHWLRQTRRRTSGVLPDSCEQLMPPGDWKEHDVETPYGMLHVVIRGAPKGNKPAILTYHDVGLNHKLCFNTFFSNEDMQEITKHFVVCHVDAPGQQTGASQFPQGYQYPTMDQLAGMLPTVVEHFGFKSIVGIGVGAGAYILAKFALIFPELVEGLVLLNIDPNGKGWIDWAATKLSGLTSALPDTVLPHLFSQEELVSNTELVQSYRQQINNNINHFNLQLFWNMYNSRRDLEMNRSGTVLNAKTLKCPVMLVVGDNAPAEEGVVECNSKLDPTNTTFLKMADSGGLPQLTQPGKLTEAFKYFLQGMGYMPSASMTRLARSRTASLTSGGSVEGSRSRACTHSDSTEGVGAVTHTMEVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CGC8</accession>
    <name>A0A3P9CGC8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle transport through interaction with t-SNAREs 1A</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561353.1">
        <property type="nucleotide sequence ID" value="XM_004561296.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CGC8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021202"/>
    <dbReference type="Ensembl" id="ENSMZET00005021901.1">
        <property type="protein sequence ID" value="ENSMZEP00005021202.1"/>
        <property type="gene ID" value="ENSMZEG00005015915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471409"/>
    <dbReference type="KEGG" id="mze:101471409"/>
    <dbReference type="CTD" id="143187"/>
    <dbReference type="GeneTree" id="ENSGT00950000183192"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15891">
        <property type="entry name" value="SNARE_Vti1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000024">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000001">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="124"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="34"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="224" mass="25993" checksum="47D3C2FFE5B9585F" modified="2019-02-13" version="1">MSSDFEAYEQDFGTITAEITNKIGRIPKLSGEEKTQLVLNVDKQLEEVRELLEQMDLEVREIPIQSRAMYNSRLKSYKQEMEKLEKDFKRSRIAYSDEVRNELLGDDASSSESQLVKLREERAHLLDNTEKLERSSRRLEAGYQIAVETEQVGQEILANLHSDREKIQRARERLRETDANLGKSSRILTGMLRRIIQNRVLVFILGAIILLTIILAIYFNVRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CI16</accession>
    <name>A0A3P9CI16_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase H+ transporting accessory protein 1 like</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vacuolar ATPase subunit S1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CI16"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005021491"/>
    <dbReference type="Ensembl" id="ENSMZET00005022201.1">
        <property type="protein sequence ID" value="ENSMZEP00005021491.1"/>
        <property type="gene ID" value="ENSMZEG00005016140.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158156"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030641">
        <property type="term" value="P:regulation of cellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008388">
        <property type="entry name" value="Ac45_acc_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046755">
        <property type="entry name" value="VAS1_LD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471:SF3">
        <property type="entry name" value="ATPASE, H+ TRANSPORTING, LYSOSOMAL ACCESSORY PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12471">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05827">
        <property type="entry name" value="VAS1_LD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1 luminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="8">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005021491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="162" mass="18318" checksum="CDDA252D4330B485" modified="2019-02-13" version="1">LVLSIKGSLQLSNTFYESSGQWWFSVDSVSLLYNISEEAAFNASEVYAPASSSYRCIHVSSLERYSALLLPGTDQARRWSITFTDFQIQAFSVTSGKFSPASDCTTFLTPAILMGLVTSLILLLVLAYALHMLIHLKHIEHDEEHKTFKSYSFEKVYVSYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CJE8</accession>
    <name>A0A3P9CJE8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CLPTM1 regulator of GABA type A receptor forward trafficking</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004543647.1">
        <property type="nucleotide sequence ID" value="XM_004543590.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CJE8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005022415"/>
    <dbReference type="Ensembl" id="ENSMZET00005023162.1">
        <property type="protein sequence ID" value="ENSMZEP00005022415.1"/>
        <property type="gene ID" value="ENSMZEG00005016791.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101474636"/>
    <dbReference type="KEGG" id="mze:101474636"/>
    <dbReference type="CTD" id="1209"/>
    <dbReference type="GeneTree" id="ENSGT00530000063461"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF14">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005022415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="634" mass="73269" checksum="06DFF6018CF44C4E" modified="2019-02-13" version="1">MATQESGVTKATVSNGEVSSNGTAATTDGQTVQTAGNAQDPQQQQQQQQAPNAWQVIKGVLFRIFIIWAISSWFRRGPSTPDPSTPAGAPRVPSRNLFPKDTLMDLYVYVSQEEVFSDFNNTDALFWFHRDLVYGDWTTGEDGDGCYQHYKEMDIPEKIQQNGSLYIHLYFTKSGFHPDPKRKGQYRRLATVHATRMLNKYKRRKFLKTKNLLTGETEADPEMIKRAESHGPVEIISHWHPNLTINMVDDHTAWVKGSVPPPLDQYVKFDAVSGDYYPIVYFNDYWNLQKDYYPINETLKSLPLRLSYCPLSLWRWQLYAAQNARSPWNFLPEDTYEQSDEDQDSVKVALLETNPYLLGLTIVVSIVHSIFEFLAFKNDIQFWNSRQSLEGLSVRSIIFGVFQSLVVLLYILDNETNFVVQVSVFIGLLIDLWKITKVMDVKLDRENKFVGVFPRLVFKDKSTYVESSTKIYDDMAFKYLSWLLYPLFGCYAVYSLLYVEHKGWYSWVLSMLYGFLLTFGFITMTPQLFINYKMKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPMMYRIGCLRDDVVFFIYLYQRWIYRVDPNRVNEFGTSGVDHAQNNTAAPAPDAASAAITDKPEGEKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CLV3</accession>
    <name>A0A3P9CLV3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfotransferase</fullName>
            <ecNumber evidence="1">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="1"/>
    <dbReference type="AlphaFoldDB" id="A0A3P9CLV3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023014"/>
    <dbReference type="Ensembl" id="ENSMZET00005023771.1">
        <property type="protein sequence ID" value="ENSMZEP00005023014.1"/>
        <property type="gene ID" value="ENSMZEG00005017237.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164185"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF66">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018181900" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="461" mass="52346" checksum="D586224465BB532E" modified="2019-02-13" version="1">MYVALKLNTIVCVCVCVCVCASVAFQHCQWKGCRVRGGGRMECSWKTVLLLVCASLGVQYTAIRTLRDSLSGPCQGAYRCQSRHLRDSRWRTSCDDSWLPMASPRKHILLFATTRSGSSFTGQLLNQHPGVFYVFEPLYHVQQAFTNSSSRLRRTLDRRALLGAYRDLLLNLYTCELHFMENYIRPEPQDHITSSFFRRSSSHALCSPPVCSDGVVAAASDPPDETWCPKKCGALNLTLASMSCLSRGHVAVKTVRVPEVGDLRTLTEDPRLDLKIVHLVRDPRAILASRMMAFSDQFRAWKIWNATGRQPRYVDLSQITSTCKDMAASVETGLQRPAWLRGRYLLVRYEDLAFNPKDKASEIYKFAGLEMEDRVRTWIAKNTNSNASSPSEWNYRYSTTRDSRVTAESWRLRLGFDIVRTVQNLCNDTLALLGYKQVRSVAELKNLSQSLVEHRTFQPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CPD6</accession>
    <name>A0A3P9CPD6_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal-regulatory protein beta-2-like</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CPD6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005023651"/>
    <dbReference type="Ensembl" id="ENSMZET00005024425.1">
        <property type="protein sequence ID" value="ENSMZEP00005023651.1"/>
        <property type="gene ID" value="ENSMZEG00005017690.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234530"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052051">
        <property type="entry name" value="TCR_complex_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433:SF133">
        <property type="entry name" value="IMMUNE-TYPE RECEPTOR 5 PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19433">
        <property type="entry name" value="T-CELL RECEPTOR ALPHA CHAIN V REGION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017972169" evidence="8">
        <location>
            <begin position="18"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="43"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="116"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005023651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="233" mass="26131" checksum="FCFA3E43D0888813" modified="2019-02-13" version="1">MVVLWITLLFLHQGSKGGFVSVCLFFVLSDHLTKLNVLFIRKVQWYKQRVGDTLKLLVSLPGKPSSEFFQSRFSAHNSKDFSNLTIWNVAQEDEGMYHCGIDTWIKLEWSGTYLTSNYIVVQQPTESNPLRPGDTATLQCSVLTNSENNTCSGHHNVFWFRDGSNKSLPNIIYTHGNRTDQCEKRSDPQDGCVYRFSKNVSSSDAGTYYCAVATCGEILFGNGTTLDVQGICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CQV2</accession>
    <name>A0A3P9CQV2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cAMP-responsive element-binding protein-like 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004564967.1">
        <property type="nucleotide sequence ID" value="XM_004564910.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CQV2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024444"/>
    <dbReference type="Ensembl" id="ENSMZET00005025246.1">
        <property type="protein sequence ID" value="ENSMZEP00005024444.1"/>
        <property type="gene ID" value="ENSMZEG00005018274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464176"/>
    <dbReference type="KEGG" id="mze:101464176"/>
    <dbReference type="CTD" id="1389"/>
    <dbReference type="GeneTree" id="ENSGT00390000005388"/>
    <dbReference type="OrthoDB" id="5984119at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14709">
        <property type="entry name" value="bZIP_CREBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000044">
        <property type="entry name" value="cAMP-responsive element-binding protein-like 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039250">
        <property type="entry name" value="CREBL2/REPTOR-BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21051:SF4">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005024444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="121" mass="13689" checksum="C1B45BB3BC9934F7" modified="2019-02-13" version="1">MEDNKMAGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSKERAICALREELEMYKQWCSAMDQGKIPSEIKALLTGDEQKMPPSGGNKTSKNSKNNISSSNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CR31</accession>
    <name>A0A3P9CR31_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CR31"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005024534"/>
    <dbReference type="Ensembl" id="ENSMZET00005025337.1">
        <property type="protein sequence ID" value="ENSMZEP00005024534.1"/>
        <property type="gene ID" value="ENSMZEG00005018347.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000203553"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
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    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="14">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="RuleBase" id="RU000528"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSMZEP00005024534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="99" mass="10971" checksum="4C0B165884D0424E" modified="2019-02-13" version="1">MTSEGKGGKGLGAKRHRKVLRDNIQGITKPAIRSLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKSQGRTLYGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CVI9</accession>
    <name>A0A3P9CVI9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004572497.1">
        <property type="nucleotide sequence ID" value="XM_004572440.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CVI9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026094"/>
    <dbReference type="Ensembl" id="ENSMZET00005026935.1">
        <property type="protein sequence ID" value="ENSMZEP00005026094.1"/>
        <property type="gene ID" value="ENSMZEG00005019462.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101480661"/>
    <dbReference type="KEGG" id="mze:101480661"/>
    <dbReference type="GeneTree" id="ENSGT00930000151022"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000121">
        <property type="entry name" value="protein disulfide-isomerase TMX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018124432" description="protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="422" mass="47117" checksum="9A66D029CEE1BD49" modified="2019-02-13" version="1">MADRRTTVLLSVLLFASAAAFVEELDDSFMETKGDDEIWLIKFYAPWCTFCKQLDPVWHQIGSEYRSLGSPVHVGKSDATANTGLAKEFRVRTYPAILMLKKNIKYNYSGVRTKDGIMDFANRIAGPLVRSLSSVQLFQHAMSRHDVMFVYVGATSPLKGNYTSVAEQLIVHTYFFSTSRDVLPKAVSLSTLPAVVVFKDGTYFTYSEERDGDLKLWINRERFPNFSQIDSYTLYAMGETGKLVLLALVEEKHLCEESLRYKSLLESVAAEHREIYSREMYFGFMAGSDYISGLVMGEIIVPTFIVVNLSNDGYFLPPGTVQTEQNLLDFLDGVLNGSMQGHGGNGALQRVRRLVYDTRVTLAPVFSHAPLLGCFLVAFPLTIGACFCYLCFKARPTVVDEDGTPLLAPPLGGHKKSKKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CXH3</accession>
    <name>A0A3P9CXH3_9CICH</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized LOC101474201</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9CXH3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005026516"/>
    <dbReference type="Ensembl" id="ENSMZET00005027373.1">
        <property type="protein sequence ID" value="ENSMZEP00005026516.1"/>
        <property type="gene ID" value="ENSMZEG00005019778.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183109"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021684">
        <property type="entry name" value="WBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051994">
        <property type="entry name" value="WW_domain-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16209:SF5">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11669">
        <property type="entry name" value="WBP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005026516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="464" mass="50854" checksum="198F1AD342C27F13" modified="2019-02-13" version="1">MARHPKYCPGVNNSPGYLCETGHCCGETGCCTYYYELWWFWLLWTVLILFSCFCAYRHRRAKLRIQQQQRQREINLIAYNGACNYPSSMLDLSFLASFKLPSYEEVVAQPSTPPPPYSSIFALQGGATVGPSSSYPHHHHHRHPCPPYLGPGPSGLTSSQSSDNYTSCSCESCSLTSPSSTSFSVQVTDETYDSSHMSTPSEAGGDLAVVPRVGVPFTLMPSPPSQVPPDVIPTVTPDVIPVQRCSSNGSEGVSPPSHPLTLTLHSRPSHSSRLPLSPLSLLSSIPAGQVHPLVPSDPLEAMALQRAKEETSPHDPKTRPLHSAPKQALLLSNVAVSVHCGGKEEQKREKEEEEEDDDEDEDEEDHFRHRRLTGDSGIEVCRCHVKRGQQEDEEPKKGRFDKGGKDVVKEGEKVLQDGVDCSQQKKVAAQSSSTDDCAEQRGHVSSPSSVIINRNEAIITVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9CZ37</accession>
    <name>A0A3P9CZ37_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clavesin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Retinaldehyde-binding protein 1-like 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9CZ37"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005027086"/>
    <dbReference type="Ensembl" id="ENSMZET00005027954.1">
        <property type="protein sequence ID" value="ENSMZEP00005027086.1"/>
        <property type="gene ID" value="ENSMZEG00005020207.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159947"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.20:FF:000001">
        <property type="entry name" value="Alpha-tocopherol transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000002">
        <property type="entry name" value="Alpha-tocopherol transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF72">
        <property type="entry name" value="CLAVESIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="13">
        <location>
            <begin position="97"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005027086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="326" mass="37531" checksum="31F41C02773F5005" modified="2019-02-13" version="1">MMSHLHAGLSSETTEKARLELNENPDTLHQDIQQVRDMIVTRPDIGFLRTDDDFILRFLRARKFDQMETFRLLAQYFQFRQQNLDMFQSFKVDDPGIKRALTDGFPGVLETPDQHGRKILILFASNWDQSRNSFTDILRAILLSLEVLIENPELQINGFILIIDWSNFSFKQASKLTPNILKLAIEGLQDSFPARFGGIHFVNQPWYIHAMYTIIKPFLKDKTRKRIFLHGNNLNSLHQLIHPECLPSEFGGTLPPYDMGIWARTLLGPDYNDETEYTLTYDALHVRENCGGGGDKDMMKRSQSAVEPGTLRQTDRETSTPLLALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D081</accession>
    <name>A0A3P9D081_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D081"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005028050"/>
    <dbReference type="Ensembl" id="ENSMZET00005028945.1">
        <property type="protein sequence ID" value="ENSMZEP00005028050.1"/>
        <property type="gene ID" value="ENSMZEG00005020930.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000178828"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005028050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="107" mass="11559" checksum="312AB1A73A25F205" modified="2019-02-13" version="1">MLRITIGLGSAAGFLFVAGLWFVGRLGFVGEFLFIGRFLFVGGFLFVAGLGFVAGFLFVTGFFVCRRFVIGFLFVAGILFAAGLGFVRVWIFSPSSLCEAPRLKLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D4H7</accession>
    <name>A0A3P9D4H7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Procollagen C-endopeptidase enhancer 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546845.1">
        <property type="nucleotide sequence ID" value="XM_004546788.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D4H7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029473"/>
    <dbReference type="Ensembl" id="ENSMZET00005030401.1">
        <property type="protein sequence ID" value="ENSMZEP00005029473.1"/>
        <property type="gene ID" value="ENSMZEG00005021986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485147"/>
    <dbReference type="KEGG" id="mze:101485147"/>
    <dbReference type="CTD" id="393432"/>
    <dbReference type="GeneTree" id="ENSGT00940000157649"/>
    <dbReference type="OrthoDB" id="6116165at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03576">
        <property type="entry name" value="NTR_PCOLCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000026">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035814">
        <property type="entry name" value="NTR_PCOLCE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF31">
        <property type="entry name" value="PROCOLLAGEN C-ENDOPEPTIDASE ENHANCER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018281286" evidence="8">
        <location>
            <begin position="41"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="171"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="10">
        <location>
            <begin position="317"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005029473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="435" mass="48145" checksum="591174362FB0DBEA" modified="2019-02-13" version="1">MPFTPPGENRRSSCSVFPTMWRTCSIFCAWTLLFLTEVCAQSQQRPIFTCGGNITGESGVIGSQGYPGVYPPNTKCVWRITVPEGKVVVLSFRFIDLENDNLCRYDYVDVYSGHVNGQRLGRFCGTFKPGALVSTGNKMLLQMVSDANTAGSGFLAVFSAAHTHERGDQYCGGRLVKPSGTFKTPNWPEKDYPAGVTCSWHIVAPKNQIIEVKFEKFDVERDNYCRYDHVSIFNGPEINDAKRIGKYCGDSPPAPVLSEGNQLLIQFLSDLSLTADGFIGHYKFRPKKFPTTTVLPATTTQPVTTRPIPLKYSVALCRQKCKRQGTLESNYCSSNFVITGTVITAVIRGGSMHATVSIINVYKEGNLAIQQAGKTMSTKIVILCKKCPVIRRGLNYIFMGQVDEEGHGKIAPHHFVMAFKTKNQKGLNVLINKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D5Z2</accession>
    <name>A0A3P9D5Z2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:29568"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9D5Z2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005029577"/>
    <dbReference type="Ensembl" id="ENSMZET00005030511.1">
        <property type="protein sequence ID" value="ENSMZEP00005029577.1"/>
        <property type="gene ID" value="ENSMZEG00005022049.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159291"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Clc chloride channel"/>
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        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 6"/>
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    <dbReference type="Pfam" id="PF00571">
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        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00762">
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    <keyword evidence="4" id="KW-0050">Antiport</keyword>
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    <keyword evidence="12 21" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
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        <location>
            <begin position="130"/>
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        </location>
    </feature>
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        </location>
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            <begin position="330"/>
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        <location>
            <begin position="368"/>
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        </location>
    </feature>
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        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="483"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="517"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="547"/>
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        </location>
    </feature>
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        <location>
            <begin position="804"/>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    </evidence>
    <sequence length="866" mass="97264" checksum="7C33C0399F2E5D78" modified="2019-02-13" version="1">KMACCGRCFCCQCCCREGETRTPEELTILGEIPDEEQILPRKDYESLDYDRCISEPYVEVLEGMDNKKAKKYEAVHWMMVFAIGVTVGLLGLFVDFFVRLFNKLKFTVVGDSIEKCSDKGCLSLSLLELLAFNMTFVFIASVLVLIEPVAAGSGIPEIKSYLNGVKIPGIVRLRTFLCKAAGVLFSVAGGLFVGKEGPMIHSGAIVGAGLPQFQSITFRKIKFDFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQALTWKVLFCSMSATFTLNFFRSGINFSKWGSFQLPGLLNFGEFKCPDGDKNCHLWTAVDLAFFVLMGVVGGLLGALFNCMNKNLAKYRIRHIHPKAKFIRVLESLLVTMVTTIVIFAASMLGECRDLSLKPSDGLFSFRLRLTHDINSTIRQFFCSNKTYNDMATLFFNPQEAAIHQLFHQDGTFSPVTLSVFFFLYFLLACWTYGVSVPSGLFVPSLLCGAAFGRLVANVLSSVRKLGMDIYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMITLMVAKWTGDFFNKGIYDIHIQLRGVPLLEWETEVEMDRLTASDIMETNLTYVYPHTRVQSLVSILRTTVYHAFPVVTENRQNERDFMKGNILISNNIHFKKSSVVSRAGEQRRRCQSMKSYPSSELRNVCDEQSAAVEPSEEGEDLLQQMLERRHAPYPNLYPDQSPSEEWTMEERFRPLTFHGLILRSQLVNLLIRGVCYAENQSSTNQPRLSYAEMTEDYPRYPDIHDLDLTLLSPRMIVDVTPYMNPCPYTVSPNARISQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTHEFLMAKLRQHYITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D6Y1</accession>
    <name>A0A3P9D6Y1_9CICH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
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            <taxon>Maylandia zebra complex</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D6Y1"/>
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        <location>
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    </evidence>
    <sequence length="520" mass="60368" checksum="8E77E7EE0959CD41" modified="2019-02-13" version="1">MVLSRKRVECPLRVGDEFLPQVEEFKYLGVLFASDGRRELEIDRRIGAAAAVMRTLHRSVVVKRELSVKAKLSIYRSIYVPTLTYGHELWVVTERTRSRIQAAEMSFLRRVAGLSLRDRVRSSAIREGLRVEQLLLHIERSQLRWFGHLARMPPGRLLGEVFQTKEFECRHYSGACERFPLQLSHAITRGDRGHPEERRSMVRIVVEAMQVNCRNPKRASSEEVAKIIVNRYPQTFADFTEKGERLGCGHYSLLRSIKSRVEHVNQDNTTHRLRQTKRTRNEEDCNPSSNATSPKKVRCLVDSYGCINWQPEKKHILLTIFNLEGPGAVERPDVDDFMCLTYISQRQLINSCPSLSVAEIQEQWPFLFTWKGLSNHFYKLTGIDISERLGQALITKGRRIINYFSSQKLKWNLDVSFFHTETSTRMSLEAEINLPSTPRLIMLVTHYFKSQLNVTVCYYLLWHVLRFSLRINPEEGTKCTSKVGRSRKTGTTVSRKVVHINPHVTTFLQRLTEFEWRTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9D7K7</accession>
    <name>A0A3P9D7K7_9CICH</name>
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        <submittedName>
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    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
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    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_004556330.1">
        <property type="nucleotide sequence ID" value="XM_004556273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9D7K7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005030334"/>
    <dbReference type="Ensembl" id="ENSMZET00005031287.1">
        <property type="protein sequence ID" value="ENSMZEP00005030334.1"/>
        <property type="gene ID" value="ENSMZEG00005022606.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101479735"/>
    <dbReference type="KEGG" id="mze:101479735"/>
    <dbReference type="CTD" id="100537916"/>
    <dbReference type="GeneTree" id="ENSGT01150000286942"/>
    <dbReference type="OrthoDB" id="9939725at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036505">
        <property type="term" value="F:prosaposin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="DOI" id="10.1038/nature13726"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005030761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1089" mass="119677" checksum="2C1973F1229F69F0" modified="2019-02-13" version="1">NKDRSCSHSQLTHCSVCSRGLWLFPDFGIDVLSTNGSQEPHGPGLLKVSGLERSQERSQESCRDSQLPVPSTPNPPLSPPTLPVSLPQPQPSIPQTPSPLRTQPNGPTQPLNHLPPRSEALPRPQSPAALPLAQGQEPSPTPPPRHQHQPEVLSHPRPPPTPSLHPHPPSPALPNHHSHQQHPIQSGSHRPPSRCHPRPLSAYNSLSLNGHSSRSSTPGTKPHGPPTPSLHLPHHPPPPPAAAAASTFPLALPTNQNNPHSFPSALQSSPHPHHPNMFAPPAALPPPPPLTSSTLPVPGHPAAGSAYSEQDLLRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHQHTHQHTHQHTFTPFPHAIMPTPAPPMVRTPARNFDKYPTKVDPFYRHSLFHSYPPAMSGLPPVIPPTGPFSSLQGAFQPKTSNPLDVSARPGAVPHTFLQKDPRLTDPFRPILRKPGKWCAMHVHIAWQIYHHQQKVKQMQVDPHKLDFGLKPEFLSRPPGPSLFGAIHHPGDLARPATLFSAAGPTHPSAAPFGHPPHHPGNFLPPASHLEPFSRPPSFGGLGSLSSSAFGGLGNPALRANSVFGHKDGPNAPQHFNSSSNNSHQEPWNRLHRTPPSFPTPPPWLKPGESERSASVSSHERDRDSDKRDSLVSKEDKDRDSVEKRHPSHPSPVPVNPISLLSHSRPPEHHRNHLPPASGEPQREKENKAKEREREHSDSWKDNGTDDHKLKDSQHSDKDTPVIHDGRASEDKMSNRGSASPYVRQTSLERPNGGLTRDVLEKKAELPYEHQKKSSEVKVKEERKEEQDGGAERASEHLQQASSTPNLHPPSSVPVSMGMPVVHPINSISSLERTRVVAPFMGISPIPGADRFPYPPFHWDPMRDPYRGLDIHRRDPLARDLLLRNDPLHRLAGPRLYEAERSYRDREPHDFNRDHAHPLALEQRREQERAQLEERDRLNMLREDYEHGRLHPAVHHPALDGHLPHPAPGLMAPGLAGMHYSRVSPSAAAAAAAAAAAAATAHQNGILNKTPPTASLSAPPPLIPTLGTRPGSPRRTTPLGTDIRDRPAHKDIEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DB83</accession>
    <name>A0A3P9DB83_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dehydrogenase/reductase SDR family member 6</fullName>
            <ecNumber evidence="10">1.1.1.104</ecNumber>
            <ecNumber evidence="11">1.1.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">(R)-beta-hydroxybutyrate dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">3-hydroxybutyrate dehydrogenase type 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">4-oxo-L-proline reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Oxidoreductase UCPA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Short chain dehydrogenase/reductase family 15C member 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20521"/>
            <dbReference type="ChEBI" id="CHEBI:10983"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.104" evidence="10"/>
    <dbReference type="EC" id="1.1.1.30" evidence="11"/>
    <dbReference type="RefSeq" id="XP_004549579.1">
        <property type="nucleotide sequence ID" value="XM_004549522.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012774184.1">
        <property type="nucleotide sequence ID" value="XM_012918730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DB83"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005031639"/>
    <dbReference type="Ensembl" id="ENSMZET00005032671.1">
        <property type="protein sequence ID" value="ENSMZEP00005031639.1"/>
        <property type="gene ID" value="ENSMZEG00005023604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470397"/>
    <dbReference type="KEGG" id="mze:101470397"/>
    <dbReference type="CTD" id="56898"/>
    <dbReference type="GeneTree" id="ENSGT00940000156721"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003858">
        <property type="term" value="F:3-hydroxybutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016617">
        <property type="term" value="F:4-oxoproline reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043249">
        <property type="term" value="P:erythrocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042168">
        <property type="term" value="P:heme metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042541">
        <property type="term" value="P:hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05368">
        <property type="entry name" value="DHRS6_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000211">
        <property type="entry name" value="3-hydroxybutyrate dehydrogenase type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005031639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="245" mass="26508" checksum="BD1CDFDA903ED00D" modified="2019-02-13" version="1">MGRLDGKVIVLSAAAQGIGRAAAMAFAKEGAQVTATDINGEKLKELDGIQGIRTKVVDVTKKDQVEALAKEHDHVDVLFNVAGFVHHGTILDCEEDDWDFTMNVNVRSMYLMSKAFLPKMLAKKSGNIINMASVASSIKGVVKRCVYSTSKAAVIGLTKSIAADFIEQGIRCNCVCPGTVDTPSLRGRIQAQPDPEQAYKDFMARQKTGRLCTAEEVAHLCVYLASDESAYVTGTEHIIDGGWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DCJ1</accession>
    <name>A0A3P9DCJ1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an essential role in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004575210.1">
        <property type="nucleotide sequence ID" value="XM_004575153.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DCJ1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005032395"/>
    <dbReference type="Ensembl" id="ENSMZET00005033439.1">
        <property type="protein sequence ID" value="ENSMZEP00005032395.1"/>
        <property type="gene ID" value="ENSMZEG00005024133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478680"/>
    <dbReference type="KEGG" id="mze:101478680"/>
    <dbReference type="CTD" id="10548"/>
    <dbReference type="GeneTree" id="ENSGT00940000158667"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF177">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017849708" description="Transmembrane 9 superfamily member" evidence="8">
        <location>
            <begin position="33"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005032395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="608" mass="68578" checksum="BF174F246CEF5FB5" modified="2019-02-13" version="1">MCRGTGRTSGGCQRMMLHSVLILFLFLGWALGYKIGDNVTLYVNKVGPYHNPQETYHYYTLPVCRPEKVHHKSLSLGEVLDGDRMAESLYNIRFKKNVEKTILCQLTLSEKQVDELREAIEELYYFEFVLDDIPIWGFVGYIEESGFLPHSHKVGLWTHLDFNIEYNGDYVIFANVSVKDVKPVPLEEGAGAAVGGVGVGGGSLTVTHTYSVHWFESSLPYSRRAERLRDYSFFPKTLEIHWLSIINSLVLVVLLLGFVIIILMRVLKNDFARYNVEEEGGCDDLDQGDNGWKIIHTDVFRFPPFKSLLCAVLGVGAQFLTLATAIILMALLGMFNVHRHGAINSASIVLYALTSCVSGYVSCSFYTQINGQRWVWNIILTSSLFSAPLFFTWSVVNSVHWWSGSTQALPATTVLLLLGAWLLVGFPLTIIGGIVGKNRAGSFQAPCRTRNIPRQIPTQPWYKHTIVHMAIGGFLPFSAISVELYYIFATVWGREHYTLYGILLCVFAILLSVGACISVALTYFLLSGEDYQWWWRSVLSTGSTGIFIFVYSVFYYRNRSSMSGLVQSTEFFGYSLLTAMVFSLMLGSVSFWSSLAFIRYIYRSLKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DFD9</accession>
    <name>A0A3P9DFD9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DFD9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005033099"/>
    <dbReference type="Ensembl" id="ENSMZET00005034202.1">
        <property type="protein sequence ID" value="ENSMZEP00005033099.1"/>
        <property type="gene ID" value="ENSMZEG00005024689.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234537"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057667">
        <property type="entry name" value="HTH_SB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF135">
        <property type="entry name" value="SI:DKEY-77F5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25787">
        <property type="entry name" value="HTH_SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sleeping Beauty transposase HTH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="149"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37232" checksum="3B55AABE8C1ED799" modified="2019-02-13" version="1">MAKTKELSKDTRKSIVDLHQTGKSESTIGKQLGVKKSTVGAIIRKWKTYKTTDNLPRSGAPRKISSCGVKMIMRTVSKDPRTTRGDLVNDLQRAGSKVTKVTISNTLQRQGIKSRSARRVPLLKPVHVQARLKFAREHMDDTAEDWENVMWSDETKVELFGINSTRRVWRTKNTELHPKNTIPTVKHGGGNIMLWGCFSAKGTGRLIRVKDRINGAMYREILSQNLLPSVRTLKMKRGWVFQHDNDPKHTARATKEWLRKKHLKVLEWPSQSPDLNPIENLWRELKVRVARRQPQNITALEKICMEEWAKIPATVCANLVKTYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DG12</accession>
    <name>A0A3P9DG12_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DG12"/>
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        <property type="protein sequence ID" value="ENSMZEP00005033112.1"/>
        <property type="gene ID" value="ENSMZEG00005024699.1"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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        <property type="entry name" value="TRIPARTITE MOTIF CONTAINING 14"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005033112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="91" mass="10636" checksum="0B2B0D34793210A8" modified="2019-02-13" version="1">MLLCKDNHYSAWHDYKVTEIRLSQHPAGFQKVGVFLNWPAGILSFFDISSDTPVHLHTFFCRFTEPVYPALWFWFTLEMYKCSAALCDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DLC5</accession>
    <name>A0A3P9DLC5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Urotensin 2, alpha</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the urotensin-2 family.</text>
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        <property type="nucleotide sequence ID" value="XM_004546323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DLC5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035199"/>
    <dbReference type="Ensembl" id="ENSMZET00005036446.1">
        <property type="protein sequence ID" value="ENSMZEP00005035199.1"/>
        <property type="gene ID" value="ENSMZEG00005026310.1"/>
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    <dbReference type="GeneID" id="101484025"/>
    <dbReference type="KEGG" id="mze:101484025"/>
    <dbReference type="GeneTree" id="ENSGT00510000049583"/>
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    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097746">
        <property type="term" value="P:blood vessel diameter maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001483">
        <property type="entry name" value="Urotensin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14447">
        <property type="entry name" value="UROTENSIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14447:SF0">
        <property type="entry name" value="UROTENSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02083">
        <property type="entry name" value="Urotensin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00984">
        <property type="entry name" value="UROTENSIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0372">Hormone</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018251012" evidence="10">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005035199.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="124" mass="13784" checksum="26B571C65CD9D012" modified="2019-02-13" version="1">MKCNHLLSWAFVLVASSPLLAHPITESAEMPYPGPVSAEDRGISSLDDLPLSEQDGTGPRYSTLISDEINRDGVRTTGLLPRGLKREVLLEKQSLLNPFSHALGIRKQFRKRGGNSECFWKYCV</sequence>
</entry>
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    <accession>A0A3P9DNB2</accession>
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        <recommendedName>
            <fullName evidence="10">Deoxyribonuclease</fullName>
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        <name type="scientific">Maylandia zebra</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
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            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
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            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNase I family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573286.1">
        <property type="nucleotide sequence ID" value="XM_004573229.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9DNB2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005035929"/>
    <dbReference type="Ensembl" id="ENSMZET00005037195.1">
        <property type="protein sequence ID" value="ENSMZEP00005035929.1"/>
        <property type="gene ID" value="ENSMZEG00005026818.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101477732"/>
    <dbReference type="KEGG" id="mze:101477732"/>
    <dbReference type="GeneTree" id="ENSGT00950000182846"/>
    <dbReference type="OrthoDB" id="10061407at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018057">
        <property type="entry name" value="Deoxyribonuclease-1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016202">
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    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="chain" id="PRO_5018181480" description="Deoxyribonuclease" evidence="12">
        <location>
            <begin position="23"/>
            <end position="312"/>
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        <location>
            <begin position="196"/>
            <end position="233"/>
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        <source>
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    </evidence>
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    <sequence length="312" mass="35775" checksum="0963A6BE59CEB363" modified="2019-02-13" version="1">MRWRSSGLSLFLLLSIFVLKSATELRICAYNVQKFDSAKASDERLMHYLKLVLTRCDISLLQHVVDPDGRAIEKLLSVLNRGSDRYEEYDYEAVASESLGNSPDDKQKYVFIYRMQTVNVTGQYQYRSQQSFVREPFVVRFQSKNASIGEFILVPLHSEPSKAVQEINKLYDVFVEVSKKWNNTNVMFLGDFHASCAYVKRSDRKNIRLFMKSEFSWLIRNREDTTVTDATSCAYDRIVVHGEPFLRAIKPFSAKVFDLGAEFKMSRSEVVQLSDHYPVEVVLKSSALLLQATPLLSLISASVILWSFLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DPJ5</accession>
    <name>A0A3P9DPJ5_9CICH</name>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
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                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Ron M."/>
                <person name="Salzburger W."/>
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                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="2">
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            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="163" mass="18558" checksum="782B20005A95DF82" modified="2019-02-13" version="1">MDDEEDDVFEPKANCWRTTFREIKCEHRGTQTPGPALVPNNGMLPCGVAEEPRPLFYGNAGFRLHFPARFELVGDHRASRQGSTEQQNSMERLPRQRPAARSVEACIGQKLQLIGDQFHWERLQLYHRNQRNQGPMWWRLAAAILSLLFDRGFIAGGGGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9DUF6</accession>
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        <scope>IDENTIFICATION</scope>
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</entry>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Cichlidae</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
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                <person name="Hofmann H.A."/>
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                <person name="Mwaiko S."/>
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                <person name="Ron M."/>
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                <person name="Okada N."/>
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                <person name="Streelman J.T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004546179.1">
        <property type="nucleotide sequence ID" value="XM_004546122.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_004546180.1">
        <property type="nucleotide sequence ID" value="XM_004546123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ARC2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000215"/>
    <dbReference type="Ensembl" id="ENSMZET00005000271.1">
        <property type="protein sequence ID" value="ENSMZEP00005000215.1"/>
        <property type="gene ID" value="ENSMZEG00005000257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101482782"/>
    <dbReference type="KEGG" id="mze:101482782"/>
    <dbReference type="CTD" id="100330322"/>
    <dbReference type="GeneTree" id="ENSGT00940000155189"/>
    <dbReference type="OrthoDB" id="10072335at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF22">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAINS PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10267">
        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="504"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="691" mass="74705" checksum="57909E0787F5E970" modified="2019-02-13" version="1">MKSQQDNMQQGDKSQMAPEGVGPSSGSVTRGSQGSGLKRAFSESDHPSLIKMSQNARASMGVLGQGLKQLFQQQRKRLSLSRSTITSSSSSSSSSVVSACGTSPCAPEDASESCCPDSDIFSAPMVPSAAGQGSAAAGMMRRGTSLQSRRSKGSGSGSGSGDRDPLLKGSPQAPQRRYTHDPQQHISRPRSSSTTDTTPSSPAPGYSSGDALLSSGYQSTEETDRIDRLEVSGLGQAPLSVSCGADSSFQGGEDITPDPHRTKQAIAQLQQKILKLTEQIKIEQTARDDNVAEYLKLANNADKQQSTRIKQVFEKKNQKSAQTIQQLQRKLEHYHRRLREAEHNGIPRQPKDVLRDMQQGLKDVGAKVTGFSEGVVDSVKGGLSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNITSLKDSLDDPSVEEGVTSTGGRSLGSTGHHFQSSPKYGSEDDCSSATSGSVGANSTTGAPGGPPSSKGNTLERSQSSSFDMLLQEVQELRDGQARLEESLEGLKSHYQRDYTVVMQALQEERFRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARTLLGKLINVLLALMAVLLVFVSTVANCVVPLMKTRSRSLSTLLLILLLAFLWRNWDALSGYTHRALQPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATP5</accession>
    <name>A0A3P9ATP5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATP5"/>
    <dbReference type="Ensembl" id="ENSMZET00005001062.1">
        <property type="protein sequence ID" value="ENSMZEP00005000983.1"/>
        <property type="gene ID" value="ENSMZEG00005000857.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234589"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001918">
        <property type="entry name" value="Immunoglobulin light 1 constant 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="50"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="156" mass="16972" checksum="0CC0E2716105C9FD" modified="2019-02-13" version="1">MILLSLFVSESESRVSLQSEVFVRRLNEFVSLWYTFGGGTRLDVGSDARPALKVLGPSNKELEQGKATLMCVANKGFPSDWSLSWKTSDSSGSSSIRGEESRTPGVLQNDGLYSWSSTLTLTADQWGKVGSVTCEATQGSHTPVSEILRRDQCSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9ATR1</accession>
    <name>A0A3P9ATR1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitogen-activated protein kinase kinase kinase 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_024654980.1">
        <property type="nucleotide sequence ID" value="XM_024799212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9ATR1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005000787"/>
    <dbReference type="Ensembl" id="ENSMZET00005000862.1">
        <property type="protein sequence ID" value="ENSMZEP00005000787.1"/>
        <property type="gene ID" value="ENSMZEG00005000660.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464541"/>
    <dbReference type="GeneTree" id="ENSGT00940000156884"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06405">
        <property type="entry name" value="PB1_Mekk2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06652">
        <property type="entry name" value="STKc_MEKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000071">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000026">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034879">
        <property type="entry name" value="PB1_MEKK2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PB1" evidence="13">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="386"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="221"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="311"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005000787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="647" mass="72208" checksum="71EFE4D212EAFD9E" modified="2019-02-13" version="1">MGESSFLASWVNRRAIKMDEQEALNSIMQDLAELHRSSRPAAFLSDLCKPKASSPKNQNDVRVKFEFKGEKRILQFPRPIKLEDLRSKAKVAFGQTMGLHYTNNELVIPLTTQDDLDKAVELLDRSVHMKSLKILLVLQVSSENSSSNMDLLPSHEELDNTGFRVTDKKSMLALIGSHSTDRSSPPPGYIPDALQQVARNGSFTSINSEGEFIPESMDQMLDPLSMSSPENSASGSCPSLDSPLDSDYPKSRMPRAQSYPDNHQDFPEYDIPVFEKSGKGGTYPRRYGIPFGLQDYSDGRKTFPRARRTQVHGFRSPISFSSTEQSPSTSSGSSVFTPDLEEVPGPARRPRRGSDIEPNPNPAVAPTLSVMDVSPPSRSPRAPTNWRLGKLLGQGAFGRVFLCYDADTGRELAVKQVQFDPESPETSKEVSALECEIQLLKNLCHERIVQYYGCLRDTMERTLSIFMEYMPGGSIKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPVLPAHVSDHCREFLKRIFVETKQRPSAEELLRHIFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVJ0</accession>
    <name>A0A3P9AVJ0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ankyrin repeat and SOCS box containing 5a</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004553679.1">
        <property type="nucleotide sequence ID" value="XM_004553622.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVJ0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001726"/>
    <dbReference type="Ensembl" id="ENSMZET00005001820.1">
        <property type="protein sequence ID" value="ENSMZEP00005001726.1"/>
        <property type="gene ID" value="ENSMZEG00005001403.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464329"/>
    <dbReference type="KEGG" id="mze:101464329"/>
    <dbReference type="CTD" id="550441"/>
    <dbReference type="GeneTree" id="ENSGT00940000165522"/>
    <dbReference type="OrthoDB" id="3246549at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000016">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF55">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX-CONTAINING 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="280"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="332" mass="36545" checksum="9EA84419F7041414" modified="2019-02-13" version="1">MSDHTEEFTNKPFAAQLSNVYLSILALFCFKLFVKISLNLLTYFYIVRGNRKEAARISAEFYDYGQQHRSWADRSPLHDAASQGRLLALRTLILQGHNVNVLTIDHVTPLHEACLGDHVACARALIDAGANVNASTIDGVTALFNACTVGSVACTEILLENGAKPQSLVYQPSPIHEATSKGHYGCVEALVTWGADVDMDIPHLGTALYTACVCQELECARKLLREGANVQKGKSLDSPLHAAAEKDCTAVVKLLLDFGADINARNTEFQRPVDVAPPSSLTEGFLLLYEATPRLLSQLCRQCIRNCVGRDRLHLLSHLPLPNRIKSYLQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AVL9</accession>
    <name>A0A3P9AVL9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 91</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP91 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AVL9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005001755"/>
    <dbReference type="Ensembl" id="ENSMZET00005001849.1">
        <property type="protein sequence ID" value="ENSMZEP00005001755.1"/>
        <property type="gene ID" value="ENSMZEG00005001389.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003024"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026720">
        <property type="entry name" value="CFAP91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032840">
        <property type="entry name" value="CFAP91_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455:SF10">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14738">
        <property type="entry name" value="CFAP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP91" evidence="8">
        <location>
            <begin position="156"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="440"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005001755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="674" mass="78410" checksum="38875E7DC69E2519" modified="2019-02-13" version="1">MCASVTNTFTKQNDAGTAVLHERAYDYLYDPVHTVSSEADHTKASFKAFASRSRIRRIPEFASMFSDNPRYTVKVDPAVPQPAFTDLQWRGHTEQRKEALQQLAGIVYDIVFHFVPFSPLIPFGQQIPPSVIYALPREDFITSDAEQKPTHFTVGVQTDYRESETQTDPYSPEYVIQPGTTPSELLQMAALTWGHGLPAGLAEVEMIQRARAKRAWEASLPPLSDLSQLDKRRRLMEEMEAKEWAFREGEIEKLQEARLEVLKDLLRQRDEAQKDVTNDRLNQIYSKHQEDRETKLNKIHADYNSILFNIYMLSTRRYLDTYEGLEELEAQLSASVLKSKRERTKPKVSEDVMKPPESRAVQLLKKYKVRTLRFLLRKETPVPHPVTPTVETPPEGEEEKELAVIFLQKLLRGRRIQYEMFKGKEKHQDLIQELRTVHALKREEQELQKADKEHVMMLNKQRDKRAELEQVFDTLSKELIRLQDERRIHAFTLLAERDRRMQEAEESGRRQVEERRRKEEDEVFREVVQVHQETVDMYLEDIILGTIEHIADQQAREEIHKRAKEVNDIAYAIEESRDNLQSEEIVSELVYSFLIPEVKKIGVRERVHQKQHRHLQAARNIIQGTSNAPELLNSTLEASKFTCPGIKASCQVLEETMSQPLQGKEAEQHDAQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AXW4</accession>
    <name>A0A3P9AXW4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chloride channel CLIC-like protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel MCLC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570306.1">
        <property type="nucleotide sequence ID" value="XM_004570249.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AXW4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002484"/>
    <dbReference type="Ensembl" id="ENSMZET00005002597.1">
        <property type="protein sequence ID" value="ENSMZEP00005002484.1"/>
        <property type="gene ID" value="ENSMZEG00005001973.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101485977"/>
    <dbReference type="CTD" id="23155"/>
    <dbReference type="GeneTree" id="ENSGT00940000165672"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009231">
        <property type="entry name" value="Chloride_chnl_CLIC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093:SF1">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05934">
        <property type="entry name" value="MCLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018173613" description="Chloride channel CLIC-like protein 1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="571" mass="65276" checksum="B801559759DDF67A" modified="2019-02-13" version="1">MFFIALLWSLSLTAVGQQEDNEWLDPYDMLNYDASTKTMRKPTEPASYDNVGTKRREYNQDPSQTELTSCKEQVEGLQKQNEDQKKTIKLISQQPTCSPVFKRFLSRLLKEIQRVGVPSDSTDVFFDAKVKLSKQAMTEIQTLLEGEDRWRTGALDNAISQILVDLKPHDYEAWKWRFEDTFGVELDTVLKIGSFVLIIVAIISTELWTTISWFVQFRRLFAVCFFVSIIWNWFYLYKIAFAEHQNNIVKMEGFNAKCTGVKKIDWSDSLKEWFRSTWTLQDDPCKRYYEVLMVNPILLVPPTKAISVTITTFITEPLKHFGQGISEFLRALLKDLPVTLQIPVLLTIVIAVVVFMYGSVQAAFQHGIMAPLRRPRTDPPPPELEQPQAQPRLRIEDCNHFAGGDAPQQQHALRYRADEARLNRNDLHQRRPNRQWVETLGTAEDEPDAERANEVPEADQNPSVEPDSENQRGAEERPPAAKDNSVGENKAKSEPKAARSDSSESKNKTSKGNENLSQDQPDRDVALLRPELPDVQPVDERPEASLEDSSLRRSVNFKAPVQETGGNNEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AYV6</accession>
    <name>A0A3P9AYV6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YIPF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">YIP1 family member 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004573852.1">
        <property type="nucleotide sequence ID" value="XM_004573795.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9AYV6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002876"/>
    <dbReference type="Ensembl" id="ENSMZET00005002992.1">
        <property type="protein sequence ID" value="ENSMZEP00005002876.1"/>
        <property type="gene ID" value="ENSMZEG00005002205.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473698"/>
    <dbReference type="KEGG" id="mze:101473698"/>
    <dbReference type="CTD" id="25844"/>
    <dbReference type="GeneTree" id="ENSGT00940000153766"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF14">
        <property type="entry name" value="PROTEIN YIPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="337" mass="37207" checksum="02D28CFF1E4B36D7" modified="2019-02-13" version="1">MSSGSGSRNTEPWGSFDDNLIQGGGSAVIDMENMDDTSGSSFEDMGEMHQRMKEEEEVAAEAAATEDDVADDGEFLGMKGLKGQLGRQVADEVWQAGKRQASKAFNLYANIDILRPYFDVEPVQVRNRLIESLIPVRMINFPQKIAGELYGPLMLVFTLVAILLHGMKTSGTVIREGTLMGTAIGTCFGYWLGVSAFIYFLAYLVNAQITMLQMLSLLGYGLFGPCIVLLVTYNIHFHFLFYGLWLLLGGLSTLRMVAALLSRTVGQTPRLLLCGTLGLLHMLFLLYLHFNYHTIIEGLLDSLEGHNMAPMQRVARDVPEVMLNATARNPGMLLSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZ56</accession>
    <name>A0A3P9AZ56_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTPRF interacting protein alpha 2</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the liprin family. Liprin-alpha subfamily.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZ56"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005002757"/>
    <dbReference type="Ensembl" id="ENSMZET00005002873.1">
        <property type="protein sequence ID" value="ENSMZEP00005002757.1"/>
        <property type="gene ID" value="ENSMZEG00005002099.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244900"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09562">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09568">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000003">
        <property type="entry name" value="liprin-alpha-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000004">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037620">
        <property type="entry name" value="LIP-1_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037622">
        <property type="entry name" value="LIP-1_SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF6">
        <property type="entry name" value="LIPRIN-ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="873"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="965"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="687"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="255"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="633"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005002757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1194" mass="136080" checksum="E942A145B9D669AE" modified="2019-02-13" version="1">MMCEVMPTISEDTALSQRGSQSSASDPDSHFEQLMVNMLDERDRLLDTLRETQESLGLAQQHLQDVIYDRDSLQRQLSSALPSCIPSIEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELTAANQEIVALREQNAHIQRKVASGEGGEDILEGSEAQQKVHGKRLSNGSLEPAHEASQVVELQDLLEKQNYELAQMKERMSSLSSRVSEVEQELETARKDLIKSEEMNNKYQRDIKEAMCQKEDMEERIVTLEKRYLSAQREATSVHDINDKLENELANKEAFLRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGSIEERMRHLECQLEEKNQELLRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNMLIQDSETYRKQYEESIQEKSQLAEDIEKLRSELDQFRLRAGSLTEPTLSRSHLDTSAELRFSLGSLAETQSDHYRSAKVIHRQRRGRIGLRETKAKSLGEPEWRSQQLGVLGGHHFESDTEMSDIDDDDRETLFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARMHHHGASITASATASSLASSSPPSGHSTPKLDPRSPARDMERMGVMTLPSDLRKHRRKIAAVDEDGREDKATIKCETSPPPTPRTVRMTHTLPASSHNDARGIVASLEAEASALSSVASSQDSLHKQPKKKGIKSSIGRLFGKKEKGRLAHLAHRQDMGVSKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKKLNYDRKELERRREQSQHEMRDVLVWSNERVIRWVQSIGLRDYANILLESGVHGALVALDDNFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTDRRLDECDDKDFRGPSWRRQFPPRDIHGISMMPGSAETLPAGFRLTATSGHSRRLPPEVGPSAVQRLDSSTVRTYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9AZI4</accession>
    <name>A0A3P9AZI4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Opsin-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">G-protein coupled receptor 136</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">G-protein coupled receptor PGR12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Neuropsin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="25 26">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9AZI4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005003078"/>
    <dbReference type="Ensembl" id="ENSMZET00005003206.1">
        <property type="protein sequence ID" value="ENSMZEP00005003078.1"/>
        <property type="gene ID" value="ENSMZEG00005002393.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271854"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005502">
        <property type="term" value="F:11-cis retinal binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005503">
        <property type="term" value="F:all-trans retinal binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016038">
        <property type="term" value="P:absorption of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007604">
        <property type="term" value="P:phototransduction, UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15074">
        <property type="entry name" value="7tmA_Opsin5_neuropsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000104">
        <property type="entry name" value="Opsin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002962">
        <property type="entry name" value="Peropsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01244">
        <property type="entry name" value="PEROPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 22" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="13 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15 22" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="17" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="24">
        <location>
            <begin position="51"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005003078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="360" mass="40361" checksum="7035EC4591E6EA42" modified="2019-02-13" version="1">MAVMENATWPHPSYLPHYLLRGDPFASRLSREADVVAALYVCIIGIMSATGNGYVIYMTMKRKTKLKPPELMTVNLAIFDFGISVTGKPFFIVSSLSHRWLFGWEGCRFYGWAGFFFGCGSLITMTVVSLDRYLKICHLRYGAWLKRHHAFLCLAFVWVYAAFWATMPLVGWGNYAPEPFGTSCTLDWWLAQASVSGQSFVMAILFFCLILPAGMIVFSYVMIIFKVKSSAKEISHYDARIKNSHTLEMKLTKVAMVICTGFLIAWIPYAVVSVVSAFGEPDSVPIPVSVVPTLLAKSSAMYNPIIYQLVDLKISASCFKVMKKQRHFRKSSIGKSFISNSVSSKSLSVMTLVMLVYSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B2A3</accession>
    <name>A0A3P9B2A3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GADD45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004561634.1">
        <property type="nucleotide sequence ID" value="XM_004561577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B2A3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004014"/>
    <dbReference type="Ensembl" id="ENSMZET00005004176.1">
        <property type="protein sequence ID" value="ENSMZEP00005004014.1"/>
        <property type="gene ID" value="ENSMZEG00005003101.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101471114"/>
    <dbReference type="KEGG" id="mze:101471114"/>
    <dbReference type="GeneTree" id="ENSGT00950000182964"/>
    <dbReference type="OrthoDB" id="8399160at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024824">
        <property type="entry name" value="GADD45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10411:SF5">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEIN GADD45 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="166" mass="19102" checksum="5FCC48B0B1D42E9F" modified="2019-02-13" version="1">MTEQWMIKMVGQALEELLVEAYHQNCLRIGVIESYKYMKANPHRVVLCVLASETEGDIMLQMNLIQLKDMCYKKNVSIMCSTDTRRLAELVNMDDINGNEASRDLHCILVTVPPVKPLPHQALQILSSFCEESRRRDSSVHCLSCYYVCSYRYPSRSCCCCCRCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B3H3</accession>
    <name>A0A3P9B3H3_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9B3H3"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005004455"/>
    <dbReference type="Ensembl" id="ENSMZET00005004657.1">
        <property type="protein sequence ID" value="ENSMZEP00005004455.1"/>
        <property type="gene ID" value="ENSMZEG00005003481.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165812"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048593">
        <property type="term" value="P:camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030902">
        <property type="term" value="P:hindbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000013">
        <property type="entry name" value="Paired box 8 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF20">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="8">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005004455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="148" mass="16550" checksum="6FA676DE605F7589" modified="2019-02-13" version="1">MQQMVSVLNQLGGVFINGRPLPHVVRQHIVELAQQGVRPCEISRRLRVSHGCVSKILARYNETGSIRPGLIGGSKPKVATPQVVQKILQLKHHNPTMFAWEIRDRLLLEQVCDQNSVPSISSINRYSVPTYYPPSLSPLWPLSPLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5R1</accession>
    <name>A0A3P9B5R1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nucleoside diphosphate phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.6" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004575351.1">
        <property type="nucleotide sequence ID" value="XM_004575294.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5R1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005233"/>
    <dbReference type="Ensembl" id="ENSMZET00005005460.1">
        <property type="protein sequence ID" value="ENSMZEP00005005233.1"/>
        <property type="gene ID" value="ENSMZEG00005004067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470512"/>
    <dbReference type="KEGG" id="mze:101470512"/>
    <dbReference type="CTD" id="955"/>
    <dbReference type="GeneTree" id="ENSGT01150000286963"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000052">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF99">
        <property type="entry name" value="ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="215"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="440" mass="48087" checksum="0FAAABFE9F57562F" modified="2019-02-13" version="1">MKRPKLAGAFLFVCCLFAYLMFVKHHYSTSKPEAYRLPPHHQPDSDLSADEGPTSDAGRRFQYGIMFDAGSTGTRIHVFKFQIEDKGAPKLAQETFRAIKPGLSAYADDPQQCTAGIVELLEVAKSSVPPSYWTSTPVVLKATAGLRLLPGEKADQLLDRVRALFLESPFLSTDDSVSIMDGTDEGISAWITVNFLTGGLHSAHSPTVGMLDLGGGSTQITFSPQDEKTIQTSPIDYIRTFQMFNHPHVVYTHSYLGLGLMSARLAILGGVGAPPLGGSPELVSPCLAPEYSGSWEHADVVYTVKGQSTGEPFYEACLNRVEKVLYQKVAKASGVTDMDFYAFSFYYDRAVDIGAIDEKKGGSIRVSDYTDAAKKGCSDVSVGPQRSPFLCLDLVYISALLQELGFPPHKQFRLARTINQVETSWALGATFHYIESLKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B5T5</accession>
    <name>A0A3P9B5T5_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HMG box domain containing 4a</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004563033.1">
        <property type="nucleotide sequence ID" value="XM_004562976.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B5T5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005251"/>
    <dbReference type="Ensembl" id="ENSMZET00005005478.1">
        <property type="protein sequence ID" value="ENSMZEP00005005251.1"/>
        <property type="gene ID" value="ENSMZEG00005004079.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101487404"/>
    <dbReference type="KEGG" id="mze:101487404"/>
    <dbReference type="CTD" id="559742"/>
    <dbReference type="GeneTree" id="ENSGT00390000012436"/>
    <dbReference type="OrthoDB" id="4777606at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025228">
        <property type="entry name" value="DUF4171"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042477">
        <property type="entry name" value="HMGXB4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584:SF1">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13775">
        <property type="entry name" value="DUF4171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="411"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="411"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="600" mass="65424" checksum="9AE535B334266EA0" modified="2019-02-13" version="1">MAFEEIKGREAIDVGMEGDRGLVAGRSQREKRRSYKDLLREEEEIAAEVRKSSKKRPKDSELFMLGGESHKKKKKHSDDYHYRDHDGSGPPPHKKKHKSSDRSPPLSSPSSSHPTDTAMGLLQAITSPLATGSDPSPHLHKKPSYPSFSSHSSKDRKRESSGGGGSTGSHSSFSHSRPTSSSSSSSKKHSSSSSSSKSSLFHGGVPKEEPLTLREADGLKMKLIMSPEKEEGESFPCTPHSSKGGVKKEKDREGALPSKSPKKKLQQNRDPLPVVGKEVEVEGHYGGGMGDESSSSGAELEAGELVIDDSYTHLSKKKKKSKKSKKKKDKEKDRDKEKSGKDKKHSKGFSDSSKSHSHSHLTVTHSAVGPMYAMGTPIPPHHHQGSDGTTEKKKKEDKDRDKHEKDKDKPKKKNTTAYQVFCKEYRVNINAEQPGLVFGELSKKLAEVWKAMPEKDKLVWRQKAQYLQHKQNKAEATTVKHKTSSETKSKVAGTSTGVVSPTRAPGTMSLSPARVPDVDPIDAAAHLQLLGESLSLIGHRLQETEGMVAVSGSLSVLLDSILCALGPLTCLTAQIPQLNGCPRNVLSNTLDNIAYIMPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6X9</accession>
    <name>A0A3P9B6X9_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial peptide methionine sulfoxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="RefSeq" id="XP_004540479.1">
        <property type="nucleotide sequence ID" value="XM_004540422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6X9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005605"/>
    <dbReference type="Ensembl" id="ENSMZET00005005845.1">
        <property type="protein sequence ID" value="ENSMZEP00005005605.1"/>
        <property type="gene ID" value="ENSMZEG00005004344.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101473872"/>
    <dbReference type="KEGG" id="mze:101473872"/>
    <dbReference type="CTD" id="503993"/>
    <dbReference type="GeneTree" id="ENSGT00940000167209"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000001">
        <property type="entry name" value="Peptide methionine sulfoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF22">
        <property type="entry name" value="PEPTIDE-METHIONINE (S)-S-OXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="11">
        <location>
            <begin position="84"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="255" mass="28807" checksum="D25F4A257DDB71D9" modified="2019-02-13" version="1">MEACRKTRATSHLRPQTQTQIVWLLVVYVCFAVAETMSDKTFDKTQMPSREAALKGREEKMVVADKHAVNGNPTVEPFPEGMETIMFGMGCFWGAEKLFWRLPGVFSTQVGYASGFTPNPTYEEVCSGLTGHTEVVRVVFSPQDISLEELLKHFWEKHDPTQGMKQHNDQGTQYRSAIYTSNPTQQEIALKSKVAFQQELEKKGYGPITTEILVGQQFYYAEDYHQQYLKKVPKGYCGLKGTGISCPIGARKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B6Y1</accession>
    <name>A0A3P9B6Y1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RALBP1 associated Eps domain containing 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004550618.1">
        <property type="nucleotide sequence ID" value="XM_004550561.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014270044.1">
        <property type="nucleotide sequence ID" value="XM_014414558.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B6Y1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005567"/>
    <dbReference type="Ensembl" id="ENSMZET00005005803.1">
        <property type="protein sequence ID" value="ENSMZEP00005005567.1"/>
        <property type="gene ID" value="ENSMZEG00005004272.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101464979"/>
    <dbReference type="KEGG" id="mze:101464979"/>
    <dbReference type="CTD" id="85021"/>
    <dbReference type="GeneTree" id="ENSGT00940000158749"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000084">
        <property type="entry name" value="ralBP1-associated Eps domain-containing protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000039">
        <property type="entry name" value="RalBP1-associated Eps domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF63">
        <property type="entry name" value="RALBP1-ASSOCIATED EPS DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="8">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="8">
        <location>
            <begin position="301"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="528"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="776"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="817" mass="88922" checksum="C7B4EB86FD9D275A" modified="2019-02-13" version="1">MESLTLSDVEQKYYSDLFVYCDTDNTKKVASNGRVLDLFRAAQLPSEVVLQITELCGATRLGHFGRSQFYIALKLIAIAQSGLPLRVESLNSVKDLPLPRFVVGKNEAEARHAALYQDPDSQGLYPAPGTAVIPRPPGRGHQNKKGHPSSTSLPVHEVIQPLATTIESQPEPTSPVVSPHQSPPTSPHSWRKHKRQHSGGNAERQPVVAATGAVWTQFREPQTGPVAGDGMWPSHSPPLPGQESWVSFTADTPPSSTLPAMHPSSVQESTTIRTVASAATTNEIQRQSSTYDDPWKITDEQRQYYINQFKTIQPDLTGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLDDSAEVPEQTADVGYSASPVEVTPNKSPSMPSLNQAWPEMNQSNEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHNHPTSPLLAKPPELSEEAKLPASMKFVAANTVGDGYSSSDSFTSDQEPITRQRSQSGTSPEALKVVAPPPPPPRPHPSHSRSSSLDMNRTFAATSATGQPQPSTIAYPPAVPPRPLPTQTSVPLTGHRVEAESIPGGAAVLTTTSPQQIPQQPNFADFSQFQAFAASEQPSSLPEVDKHIEPGQGDKPSEGAGPLRTVKSDGQADERPSATVNSGAKGSSGPLAPPPKPVRRRLKSEDELRPEDEQHGPQKSNVIAAVLATQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDLLEERISLEVQLEQLRPFSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B7E7</accession>
    <name>A0A3P9B7E7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004565840.2">
        <property type="nucleotide sequence ID" value="XM_004565783.4"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014264693.2">
        <property type="nucleotide sequence ID" value="XM_014409207.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9B7E7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005005828"/>
    <dbReference type="Ensembl" id="ENSMZET00005006081.1">
        <property type="protein sequence ID" value="ENSMZEP00005005828.1"/>
        <property type="gene ID" value="ENSMZEG00005004510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101483431"/>
    <dbReference type="KEGG" id="mze:101483431"/>
    <dbReference type="CTD" id="23397"/>
    <dbReference type="GeneTree" id="ENSGT00390000004149"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005005828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="693" mass="76081" checksum="AFD975320EA7EF39" modified="2019-02-13" version="1">MSAASTPVSRVRPGWMSSCLKNKGLSPAGSSTPLLSAFPGNDDEQERRQRRRSRVIDLQAASDSSLNDSASHSTVGTPAAVPKLSNAQISEHYSTCIKLSTENKITTKNAFGLHLIDYMADILKQKDSELTNFKVAAGTLDASTKIYAVRVDAVHADAYRVLGGLGAETKPGEGHGATEEDGDDAGLAGGEVTAKQPKKKRPPKKTVEQNLSNINSAESERRCEVDPMFQRMASSFDESSTAGVFLSVLFSESSRCELLFPSHMTLLQSRPAYSPPSPQGVPASPFMAGLQRSQEKSSVCPSLQDFSFTSWNPEQTMNQLLEKMKQGDHVFDVNNEPEPEPEEDDCPDFDGDYEEGVGDCEDGSKEHKEGCEPSGKRRDVIPIGEGDIATMCLQLSSQPREYSYFSPRTMATWAGPGYWQFKPKHKLDHLPEKETRKRKPKKTFEIDFNDDVNFDTYFRTTRAATTNTKSALSARSKKTTLPADFQFPPETLSQLSLKPSSTLSPEGQKRLSAELGEGIGDYDYNNANDTANFCPGLQGGDSDDDVEGFAGSDDTQPSSDSMPLPSQDLEGVSTYGEEDLVPEPHRVNKIEINYAKTAKKMDMKRLKNSMWTLLIDSPEKPTEGVETVEKPEVCGEKVFSQTTKTLLQRLPNTMAQNLSVALAFVALLHLANEKNLELVKVDDMSDIIIKQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9B9C7</accession>
    <name>A0A3P9B9C7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Rearranged L-myc fusion</fullName>
        </submittedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="STRING" id="106582.ENSMZEP00005006518"/>
    <dbReference type="Ensembl" id="ENSMZET00005006816.1">
        <property type="protein sequence ID" value="ENSMZEP00005006518.1"/>
        <property type="gene ID" value="ENSMZEG00005005041.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183034"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052251">
        <property type="entry name" value="GH-ZnFinger_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057986">
        <property type="entry name" value="TPR_Rlf/292/654"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058902">
        <property type="entry name" value="zf_C2H2_ZNF292/Rlf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15507">
        <property type="entry name" value="ZINC FINGER PROTEIN RLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15507:SF18">
        <property type="entry name" value="ZINC FINGER PROTEIN RLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25580">
        <property type="entry name" value="TPR_Rlf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25420">
        <property type="entry name" value="zf-C2H2_ZN292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26218">
        <property type="entry name" value="zf_C2H2_ZNF292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="688"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="758"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="921"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1149"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1288"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1354"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="952"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1189"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1331"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1439"/>
            <end position="1481"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1592"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="1647"/>
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        </location>
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        <location>
            <begin position="1699"/>
            <end position="1756"/>
        </location>
    </feature>
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        <location>
            <begin position="1801"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="952"/>
            <end position="965"/>
        </location>
    </feature>
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        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
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        <location>
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            <end position="1225"/>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005006518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1891" mass="213654" checksum="44DEF2542C5B11AD" modified="2019-02-13" version="1">MGSSDCTAYALWWRVKMAENNVEPEHEWSDWALDTAEDTLVAMENLLATLRAFEDVLRQQEISVASSTEYCDNFCQALMHYAGSRNSMEHGLPLLEVYCLSINCFASARSHLTAESDRVALVLKRLALSCFELLLSVPENEIPYEAWVQFHHSVQIAHDTLLQYGSTDLQALLQITGEGGAWSNPVLTSLLTGQLTNPEEVNAYISLEGEGFMEMRVKHLEKMGEIAKAVVLAKACTECSTFSNQATFRQTYVSLLCHLLPNEEAIMEISRLDCKDVLEITCNLETEGEENTAFILCTTFLTQQLQQQSLYCSWELILLWSKLQRRLDPSPVSLLERCLQLGAIAKTVDHLLYLVRVIQTEAEEPGIPASVELCVKALQLPKQDDSESKISVCKTVSCLLPDDLEVLRACQLTEFLLGPAQEAFSCLEELYLRPDQKYDQDSEVIPNSLRCELLLALKAYWPFDPEFWDWKTLKYHCISLLGLRPESEGEEEEAVEKDKLHELQGVTVKVESVHQNGINGGLDSHEQLDQKQSINQTDIKGDSEAKKQNFCCHICKRSISDTQVIHHSKRHAEDNNHPCPICLEKFESRKKLVPHIKKHIESETHLVKNHAKTEEVQKTIEEDDDVEPGEITIDPSLMLYYKSTHDPDVLQHIVQQAKTGTEKHVDSDEHVTFDYIDQHFKLQNRDEYPCPGTGCTRTFKHSKYLYVHLKSEHKGDENVKYFHQMRDKREKCVFCRRHFVSAYHHRKHIRVHYGDQPYACVVIGCGAQFNTSNELVTHKQTHGYQLNYQCQLKGCYVTYSDLGQIYHHEAQHFRDAAFTCSSTDCRKYYLSKKEFIKHLSTHNITFSEEDFEAQRKAKRKLFKTVTDAAIRLTKSVESDTVNGDVLNASSVSCSSSLQESDVKEPKATMTLVAVCFDGSKFTCGFEKCGMTFSRARDVQRHLKCAHPEHLKLENKEHKHDNEQGSKSKWIKSENQPENEEKGQNDPTPFQPVDTCQEKKASTHPKSSETNSLSLQTKNDALKEILIGLSRLDLNSDSLPNEPTQSSVDSNTSQISLHQAIMAKPPVVLLQKRPHLSEEKVKVLTQQATTEEGGSESLASAKPYVCEMKSCGFRTAQSYSLLRHYNTRHGRTIEQAKRLTSLKTTCFKPYVCHLCSKSHREKHVLRAHYIQFHNMSETCVDQISVTSVQHEGNKVSKSKKKLTAPLTNHGLKVKKKELPKLQHQQETKNSTAISENGKDFDNHSPSEEEGEDEQRQESEDKTTQQVRTTRRLVAKSNLCYILDKFSKPFHCVAKNCDAAFSTQGGLVRHLQLVHHYNRSQLLLEKDIDVHHSPEVRKEPAKKRPLPNSDEPQPQFKCHFANCNASYHLKSSLVRHTRDYHSQPPELLRCKYDGCTRVFSHDGALKKHTLYSHCELYDSLVVRLQSTHKKSITGCQKKLIVTPESPQKEEPGSPTAQAESPKPEVTATSEQLGDEGAAEKKVSGEKKRAKRNCFSSYVFRSHEEALQMCQDRCLRVAYPCMVQDCDSVVTYMHSLNRHYLKVHHMRREDVFKNEDKLVFTAEQLEELIQRKSARPTVAGTCVPNGVLKMEYQAESESAGAQPAPVSLHSIKGDTQDEDNHDALSFPGEEEQELPPVERNGVLVGADEVLYGEPSTGGHAEDAAAGTPSTQKPEERLSLDKIKPLLRPVTVDLSPPCSLRFTTEEGFQDGSGNKDGSKTLNGSVTLSSPPVRQPLKRMNELSEQPSNVKDSQSRSASPRAFDIAGYKPMGFESSFLKFIQETAPKDKNTGLAKRRDTFRRSCSVKENNQLGISHTRSRRTHSPLLKPHSMTGDFTSVQNLKSILDKALAGCGDLAIKQLQYLRPVVVLGRPVCTTALPDLFPTDTNNSKLLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BAP8</accession>
    <name>A0A3P9BAP8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cadherin 17, LI cadherin (liver-intestine)</fullName>
        </submittedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_024654805.1">
        <property type="nucleotide sequence ID" value="XM_024799037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BAP8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005006957"/>
    <dbReference type="Ensembl" id="ENSMZET00005007262.1">
        <property type="protein sequence ID" value="ENSMZEP00005006957.1"/>
        <property type="gene ID" value="ENSMZEG00005005358.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101479661"/>
    <dbReference type="CTD" id="1015"/>
    <dbReference type="GeneTree" id="ENSGT00940000157655"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060027">
        <property type="term" value="P:convergent extension involved in gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000163">
        <property type="entry name" value="Cadherin 17"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
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            <begin position="1"/>
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    <feature type="chain" id="PRO_5018014609" evidence="10">
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            <begin position="20"/>
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        <source>
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    <sequence length="871" mass="97440" checksum="FDE6F5912AC9BCFB" modified="2019-02-13" version="1">MTPMVHLLLLPLLLSIAGGKDLEEKKGPFENTVLDVPEATPVPYPLFQFQVTDPHVNNFRLSGEGGQDISISKDGWLYLEQPLDWSREEHYIIMVEALADEEVVEGPIYVTINVLDVNNKAPYFNQSVYTAVVRENTPAAVPFTRVFATDQDDPETPNARLRYSLVSEIPSIRDTKLFQINPDTGEISTTEQGQQLLKAREGIQYARGEDRSIETLKRKFDDYCSVQEVPYEHNPFFTCVQRAEMRRQNLDPLEDPDYTLFVRVQDLEGASQNALSGNSRVQIAVQQNLWKNPGPIRIRENLEETYPLTIAKVQSNDPDARYVLVQKERELKFPFEITQNGEIMVTEKLDRESKERFILVVLAKDENDNEVDPPMEIYVLVDDVNDNAPVCDEETVFEFQENEPVGGLVGELLAHDSDKEGTLNSVLTYTILSQNPPTASKTFSIDESSGAIRTLHLLRRRENAVYNLNVRVSDAEFSTNCKVVVKVIDVNDELPKFETNDYGNETLTEDTPLGHTLLTIKATDNDDPDTGSSEIQFIISEGNTDDVFAVETDGKGVGYLVLAKPLDFETSPSYRLQIDARNPEPLMESLKYGSESTAFFSVSVIDVDEAPKFSMDILDVTIYENITKGSVLLTVHAKDPEGKEIGYKLDGDTQGWLELDAATGEIRTKEKLDREKVDSFKVTVTAFEKANPEKATERDLHVRLLDVNDNVPKLMETQAFICMKNPKPVLIKAEDSDSNPFSQPFTFSFGTKTGKSPNWELNQVDDTTAELKLKKPPTQDKTFSLPITVKDKAGVGVPQAFEVKVCNCTELGYCYIAPEGAALSYGMGPTIGILAGILGFCVIVFVVVIKRINKKSQRKAQAKGDESNAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BC15</accession>
    <name>A0A3P9BC15_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SR-related CTD associated factor 8</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
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        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RPR"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
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            <begin position="474"/>
            <end position="548"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Ensembl" id="ENSMZEP00005007444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1353" mass="147949" checksum="8243D0AFCE26A81B" modified="2019-02-13" version="1">MEAVKAFNNELYSLNEYKPPISKAKMTQITKSGIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQFGTEKDVFAPRFSKNIISTFQHLYRCPSDDKSKIVRVLNLWQKNAVFKSDIIQPLLDMAAGIPPPSVTPVMPSSAAPVNNTTPGTPATPATPANIVQGLPDWASQITNTDTVAAVAQILQSPQGQQLQQLVQSLQMQQQKPQPSLLQALDAGLVVQLQALTAQLTAAATANSLNPLEQRVSSFNKKLLGPFDFGNDSERNEESKKDSSTSQLPMVSEPINSSLFHQLAEQLQQQNLEQFQKQLLEHQQKAMNIEGQDSIFGQENSVSNAQSSSQPQLPEPENKIDDSIDNQQQDMDLDEGPDGMEEEIFEAEEKKTLNTRSRTRSRSRSRSPKRRRSRSRSGSRKRKHRKRSRSRSRDRKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYICMVHRQDAYRARQKLSTGTFKIGSKIIKIAWALNKGVKQEYKQFWDVDLGVTYIPWEKVKLDDLDGFAEGGIIDQETVNDEWEAAKNTEQAKEAASQPVSTETTAASNTQTETFNQQVTMMPVQLPVAQAVPSAVGLVPPAFPVTMGIPPPGYGPPPPFIRASFNASQPPPGFMQAAQTAGMASASASLVQPSVGSSQDAIKDSPFGAMIPPTSTIPGSFMPSAIPGAGVFNPVGVQTQQAANEKTQSAEGMDATAELTLQGMQNAVRSGMGLLGMHPTASLTHPLHQSGLSGQRMPGLLPLDVRPNLLQPGAAARFPLLMQQAHAQQTPGLLDSPIQAQSRPRAPFPQLDPFHRPPNITSENVSKTEDESSSGADEGKDQDYRFPPMEKQSTGLLRTPPPEHREPLAGSGAGVRPPLLQTPGTQPARSSLVGRLQALAGFTPDNRWNQARGDFDERDGMRGGPQAPGGPKGFPEAGPTPGQNFPSRFDNRPGTAAGVSVNAGAVGGPQAWNRSGNAAAPFESELHQDLDERRRPWDRQRDRDERDFDFRREMNGNRRSRERERERDRGRDRTREHERERDHDKERDRERGGSAPLLPLPTPLLPTPPLNPNLTLNQGKVLAPLKLNPQIQPRFQPPLLPQAQGKLPLLGLNQAAPQLQIRSPPPSQNQAAVPEPESEIPTPSEAPQAQPTPSTLSHDPSSDGEGQSTLTEAPPKSESSPQPETSPRTDSPSQPIAQSASQTTASSDSETPSHASPPDEASSQDSSMAFTQAASPPEDTTHSAEEQKSGQKDEEESQERPSSPQPPGVSGPELDNDQSEPVEDAASLPVVDTVTDTEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BCF2</accession>
    <name>A0A3P9BCF2_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microtubule-associated serine/threonine-protein kinase pre-PK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BCF2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005007568"/>
    <dbReference type="Ensembl" id="ENSMZET00005007884.1">
        <property type="protein sequence ID" value="ENSMZEP00005007568.1"/>
        <property type="gene ID" value="ENSMZEG00005005771.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156399"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08926">
        <property type="entry name" value="DUF1908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140482">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microtubule-associated serine/threonine-protein kinase pre-PK" evidence="2">
        <location>
            <begin position="40"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005007568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="326" mass="36579" checksum="25FC2EBA480CCB1F" modified="2019-02-13" version="1">MALWFHSCRTSNRKSLIGSGQPSGLPRPHSPLSSLTGTSPQDSPRNFSPSASAHFSFARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTPDELHFLSKHFCTESISGDECRRATAMRPRSRSLSPGRSPSCYDHEIIMMNHVYKERFPKATAQMEERIQEIIRSNSPETVLPLADGVLGFAHHQIIELARDCLEKSRLGLITSSYFCELTDKLERLVQESTERSESEEVNFIRELVKKILIVIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKTDIPRYIISQLGLTRDPLEGCLFLLCFAVDKTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEF7</accession>
    <name>A0A3P9BEF7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Elongation factor RNA polymerase II</fullName>
        </submittedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_024654319.1">
        <property type="nucleotide sequence ID" value="XM_024798551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEF7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008285"/>
    <dbReference type="Ensembl" id="ENSMZET00005008615.1">
        <property type="protein sequence ID" value="ENSMZEP00005008285.1"/>
        <property type="gene ID" value="ENSMZEG00005006297.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101483375"/>
    <dbReference type="CTD" id="8178"/>
    <dbReference type="GeneTree" id="ENSGT00940000155914"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF9">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="8">
        <location>
            <begin position="519"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="629" mass="70162" checksum="AF75D4D1F610900B" modified="2019-02-13" version="1">MAALKEEQCYGLSCGRVSNGSNVSVFHVKLTDSALKAFEAYQSSRVLSSSPLIRFNGNQGKISIPRSENSSELQTFTFYLSNVGRDNPQGSFDCIQQYITSEGSIQLDCLGGIQDKITVCATDDSYQKAKESMAQVEEETRSRSAIVIKPGGRYVGKKVQIRKPAPGLSDVAPLRRTSRPVIISSSTLKKSATQHRPLRERLVHLLALKPYKKPELILRLQKDGLSPLDKDSLDSHLQQVANLNGRENTFTLKDFLYKEIQKDWPGYTEGDQQLLKRILFRKQAQNSSAPPPESPPKELASCSPSQKRPAADFIDPLANKKPRISHLASKAATPPVNGKISSSNGRGDAGSMPSGVVGSAPDGGTPSSSQQLPMLDIPRPFEALSDVSNDSSNNGRDCDSQESAVPERFSQPPSLPQTSSPRHTILEAPRDKSSSSLNTKSKKKSKKHKDKEKSKDKEKVREKEQENERKSRDECVSEPNRACETSLGNLKSNSIPHRSTDLNGMCNSTSIPSSSPEVADYLLKYTVISSPEQRQRYKNDFNAEYSEYRGLHARIEGITRQFTVLDNELKQLQHGTDKYKTVHNQILQEYRKIKKTNPNYSQEKNRCEYLHNKLAHIKKLIAEYDQQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BEG7</accession>
    <name>A0A3P9BEG7_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Si:dkey-184p18.2</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0711 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004548046.2">
        <property type="nucleotide sequence ID" value="XM_004547989.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BEG7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008295"/>
    <dbReference type="Ensembl" id="ENSMZET00005008627.1">
        <property type="protein sequence ID" value="ENSMZEP00005008295.1"/>
        <property type="gene ID" value="ENSMZEG00005006323.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101480078"/>
    <dbReference type="CTD" id="83608"/>
    <dbReference type="GeneTree" id="ENSGT00390000013383"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029779">
        <property type="entry name" value="Rmp24-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31402">
        <property type="entry name" value="UPF0711 PROTEIN C18ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31402:SF2">
        <property type="entry name" value="UPF0711 PROTEIN C18ORF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15719">
        <property type="entry name" value="Rmp24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="239" mass="26450" checksum="54383AA7691F458D" modified="2019-02-13" version="1">MEISPEIKSNSFLLDASLLYKDSCPELSRFYMQGSLKANGPLKQRFSSMLHNTGVCPYCCQWLHPDNHHVRLRPKQRPSARVQSVLLRKARGKRLSLVQKNLLCRFQKSSSVLMATCHACNKTSRYKGVNRDFIATFAKTHNTPGSAGKHKTPQSTSRSSMNAHKTPGKDRAPAHTPRFSSSSSTSTSTTTTSGSGSGSASSKPPKIRNWFVRHLSKILQQEDNQGTKKGGLKDFLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BF98</accession>
    <name>A0A3P9BF98_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein Abitram</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-binding transcription modulator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein Simiate</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABITRAM family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BF98"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008585"/>
    <dbReference type="Ensembl" id="ENSMZET00005008925.1">
        <property type="protein sequence ID" value="ENSMZEP00005008585.1"/>
        <property type="gene ID" value="ENSMZEG00005006527.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00450000040303"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032433">
        <property type="term" value="C:filopodium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051489">
        <property type="term" value="P:regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000048">
        <property type="entry name" value="Protein Abitram"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039169">
        <property type="entry name" value="Abitram"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13651:SF0">
        <property type="entry name" value="PROTEIN ABITRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019325"/>
        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
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    <sequence length="186" mass="20723" checksum="C6168E8DAF5FB21B" modified="2019-02-13" version="1">RALNSSGEILKVQPLPGTPNLLLLTHSLPAIDMKGKPCEDHCILQHSNRICVITLAETHPILQNGRTIKSINYQISNGCSRLENKVSGKSKRGGQFLTDFAPLCRITCTDETEYTIYSCIRGRLLEVNENILETPNLLLEKPSTEGYIAVILPKFEESKSITENLLNRDEFENIVSKRSSAQSQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BFV2</accession>
    <name>A0A3P9BFV2_9CICH</name>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_004563235.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_004563236.2"/>
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        <property type="nucleotide sequence ID" value="XM_004563237.2"/>
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    <dbReference type="STRING" id="106582.ENSMZEP00005008790"/>
    <dbReference type="Ensembl" id="ENSMZET00005009126.1">
        <property type="protein sequence ID" value="ENSMZEP00005008786.1"/>
        <property type="gene ID" value="ENSMZEG00005006677.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005009130.1">
        <property type="protein sequence ID" value="ENSMZEP00005008790.1"/>
        <property type="gene ID" value="ENSMZEG00005006677.1"/>
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    <dbReference type="KEGG" id="mze:101482060"/>
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    <dbReference type="GeneTree" id="ENSGT01040000240444"/>
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        <property type="component" value="LG2"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:lysophosphatidic acid receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="7tmA_LPAR4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lysophosphatidic acid receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF41">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID RECEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01067">
        <property type="entry name" value="P2Y5ORPHANR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="39"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="354" mass="39483" checksum="B8D157FAA3789298" modified="2019-02-13" version="1">MASLVINETGMVDCGIDDSFKYNLYSAVYSVVFVSGLITNCAALFVFCFRMKMQNETTMFMTNLALSDLVFVFTLPFKVFYNVNRNWPFGDGLCKVSGTAFITNIYGSMLFLTCISVDRFLAIVYPFRSRGIRTRRNAALMCAAVWLTIVGGGISVTFFSTINSRHKATTCFEGFSKNTWKTYLSKITIFIEIVGFLLPLLANLICSSLVLRTLRRPVTAGHGCDSKKRVLRMILVHLGIFIICFVPYNSILFLYALVRTQALANCTVERFVRTLYPITLCLASLNCCLDPVVYYFTSESFQKSLTKGGKGSGSRPESMPRSDTETKDTATAVPSDTHTLTSNGKETKITEIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BGB2</accession>
    <name>A0A3P9BGB2_9CICH</name>
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        <recommendedName>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <organism evidence="20 21">
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        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
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            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_024658543.1">
        <property type="nucleotide sequence ID" value="XM_024802775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BGB2"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005008927"/>
    <dbReference type="Ensembl" id="ENSMZET00005009271.1">
        <property type="protein sequence ID" value="ENSMZEP00005008927.1"/>
        <property type="gene ID" value="ENSMZEG00005006764.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101469394"/>
    <dbReference type="GeneTree" id="ENSGT00940000164068"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05938">
        <property type="entry name" value="hsFATP2a_ACSVL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000005">
        <property type="entry name" value="Solute carrier family 27 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006134">
        <property type="entry name" value="PRK08279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF23">
        <property type="entry name" value="VERY LONG-CHAIN ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="18">
        <location>
            <begin position="61"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="19">
        <location>
            <begin position="500"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005008927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="620" mass="69911" checksum="DDCEE928A6AE7F1D" modified="2019-02-13" version="1">MEIYISIILASLLIIPFALKTFSPYVWMDIVYFGDLVRILVKFVARRRRRPLFFVLDRFLEQTEAHPDNTFIVFENESYTYACTDKRSNKIANALQSHAGYKGGDTVALFMGNEPTFLFTWLALAKLGSPVALLNHNIRTKSLLHCFNCCKAKVLIAAAELKEAVEDVLPSLIEQGVTVLLMSKNSDTPGIQSFSDEVEKASDDPIPRSFRSHITFKSPAVYIYTSGTTGLPKAAVVNQNRILTALAVLSSNGVVSSDVFYLNLPLYHTAGFVVGFIGTIETGSTIILKRKFSASQFWDDCRKHNVTVIQYIGEVMRYLCCAPKKDNDKDHKVRLAIGNGIRAEIWKEFLNRFGNIQIREFYASTEGNVGFLNYVGKIGAIGRVHFFHQKLFPYTLVKYDTERDEPVRDANGLCIESRKGEPGLLVSKITNLAPFSGYAQNEEQTERKRLHNVLKKGDLYFNTGDLMRIDKDNFIYFQDRVGDTFRWKGENVATTEVSDILTICDCLKEANVYGVQVPGHEGRIGMAAVTLKKEVQFDGRKIYNHVVSCLPSYARPRFIRMQSTVEVTGTFKQMKVKLVEMGFDPGRIQDPLYILDDNAKSYVPLTAQIYHAIISGSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BH68</accession>
    <name>A0A3P9BH68_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">72 kDa type IV collagenase</fullName>
            <ecNumber evidence="4">3.4.24.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">72 kDa gelatinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Matrix metalloproteinase-2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="31 32">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.</text>
            <dbReference type="EC" id="3.4.24.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="23">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="23">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.24" evidence="4"/>
    <dbReference type="RefSeq" id="XP_004539725.1">
        <property type="nucleotide sequence ID" value="XM_004539668.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BH68"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009096"/>
    <dbReference type="Ensembl" id="ENSMZET00005009445.1">
        <property type="protein sequence ID" value="ENSMZEP00005009096.1"/>
        <property type="gene ID" value="ENSMZEG00005006880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472680"/>
    <dbReference type="KEGG" id="mze:101472680"/>
    <dbReference type="CTD" id="4313"/>
    <dbReference type="GeneTree" id="ENSGT00940000158511"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048771">
        <property type="term" value="P:tissue remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000002">
        <property type="entry name" value="72 kDa type IV collagenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000010">
        <property type="entry name" value="72 kDa type IV collagenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000002">
        <property type="entry name" value="Matrix metallopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
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    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
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    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
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    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF29">
        <property type="entry name" value="72 KDA TYPE IV COLLAGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
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    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 23" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0177">Collagen degradation</keyword>
    <keyword evidence="18 24 27" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 29" id="KW-0732">Signal</keyword>
    <keyword evidence="13 23" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018195319" description="72 kDa type IV collagenase" evidence="29">
        <location>
            <begin position="30"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="30">
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            <begin position="228"/>
            <end position="276"/>
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    <feature type="domain" description="Fibronectin type-II" evidence="30">
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            <begin position="286"/>
            <end position="334"/>
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    <feature type="domain" description="Fibronectin type-II" evidence="30">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
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    <feature type="repeat" description="Hemopexin" evidence="28">
        <location>
            <begin position="469"/>
            <end position="513"/>
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    <feature type="repeat" description="Hemopexin" evidence="28">
        <location>
            <begin position="514"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="28">
        <location>
            <begin position="561"/>
            <end position="609"/>
        </location>
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        <location>
            <begin position="610"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="26">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
    </feature>
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        <location>
            <position position="231"/>
        </location>
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    <feature type="active site" evidence="21">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="23">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="168"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="178"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="180"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
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        <location>
            <position position="185"/>
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        <ligand>
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            <label>3</label>
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            <label>3</label>
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        <location>
            <position position="190"/>
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            <name>Ca(2+)</name>
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            <label>3</label>
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        <location>
            <position position="193"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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            <position position="202"/>
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        </ligand>
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        <ligand>
            <name>Zn(2+)</name>
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        <location>
            <position position="473"/>
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        <ligand>
            <name>Ca(2+)</name>
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        <location>
            <position position="518"/>
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            <name>Ca(2+)</name>
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        <location>
            <position position="520"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>5</label>
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        <location>
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        <location>
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        <ligand>
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            <label>4</label>
        </ligand>
    </feature>
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        <location>
            <position position="548"/>
        </location>
    </feature>
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        <location>
            <begin position="233"/>
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            <dbReference type="ARBA" id="ARBA00004498"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009096.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="656" mass="74352" checksum="4A990F6E938F8081" modified="2019-02-13" version="1">MGFPTIFSCRRSLLKLFLLQFIVFQTVNARPSPIIRFPGDDTPRTDKEVALHYLNKFYGCPQDRCNLMVLKDTLKKMQKFFSLQETGEIDAKTVEIMKKPRCGVPDVANYNFFHRKPKWQNKDVTYRILGYTPDLDEEVINDAFFRAFKVWSDVTPLTFTRIMDGEADIMINFGRNEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDEQWTLGEGQVVKVKFGNADGEFCKFPFLFMGTEYNSCTAQGRDDGFLWCSTTYNFDEDGKYGFCPHELLFTLGGNAEGAPCKFPFNFQGEKYDGCTTQGRDDGYRWCATTEDYDRDKTYGFCPETAMSTVGGNADGSPCAFPFTFLGDTYESCTTSGRSDGKMWCATTKSYDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSQDPGALMAPVYTFTKDFRLSNDDIKGIQELYGVPTDKPLPPTQGPVTPMDICNEPVIFDAVAQIRGETFFFKDRFLFRSVNFRSKPNGPMLVATYWPDLPAKIDAAYENPEEKTVFFAGNEIWIYRADQLETGYPKRLSSLGLPTDLQQIDAAFNFRKNRKTYFFAGDKFWRYDETSKTMDSGFPKLIADSWNGIPDGIDSAFSLNGIDYSYFFKGNHYFKLEDSSLKIVKLGEITKDWLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BHN8</accession>
    <name>A0A3P9BHN8_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase RNA specific B2 (inactive)</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BHN8"/>
    <dbReference type="Ensembl" id="ENSMZET00005009781.1">
        <property type="protein sequence ID" value="ENSMZEP00005009425.1"/>
        <property type="gene ID" value="ENSMZEG00005006722.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157252"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000009">
        <property type="entry name" value="Adenosine deaminase RNA-specific B2 (inactive)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF17">
        <property type="entry name" value="DOUBLE-STRANDED RNA-SPECIFIC EDITASE B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="83"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="242"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="3">
        <location>
            <begin position="368"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="726" mass="80500" checksum="84BD53B9AFD7DDF1" modified="2019-02-13" version="1">MTKNIYHDIHSKICDNDITDDIIDTRQNTLQLHNFISAKKNPQKIIVFSLTQAAFLSALKLYKKLTLLYQSHSTCKRAAWGVTQKNALVHLNELRPGLQYDITSKTGPLHAPVFSVAVEVNGFHFEGRGPTKKQAKMRAAEQALQSFIQFPNASQAHATMGNFTSTPVDFTADKVDIPNGFFKEFEPSVLRNCDLLHCNAAKKEVFSSIYNHRRLVRLTLDLVSSTNPKRRAVTTSLLEDLSPVALLNELRPGLRYMCLTERVPGRPMKTFVMVVRLEGRVFEGCAPSKRLAKARAAATALQSLYNISLGPERTFMGLQDSRSIFHLVREKYTALADSCSSTSHARHKVLAGIVMTRGLDLRSAQVVSLATGTKCLDLGGVSDCGCTLTDCHAEVVSRRALVRFLYSQLELLLCENQSIFIPNKNCGDGFRLREGVHFHMYVSSSPCGDARLNCPYETTLSPLYCPCLPLSFLSSPCPGLSLDDASVKYFLLVSDPSRRFRCHLRVKVKGGEGTLPITARRANQKWDGLSPSKPLVTMSCTDKLAKWSVVGLQGALLSHLVEPVYLQSLTVGTLSHTGHLGRAMARRLAPIKHLPFPYRRQQLLLGLSSRDARPAGKPPNVSVNWSCGDGGWEEISTSTGRRKDSGTPSRLCRRSLFARWLRLQQQVRQSQKSTTGTYCASKMSAQCYQRAVQQFSSALQGGGLGTWLRKPPKLGHFTVSVSKTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BI96</accession>
    <name>A0A3P9BI96_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="3">4.1.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA photolyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Photoreactivating enzyme</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).</text>
            <dbReference type="EC" id="4.1.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="3"/>
    <dbReference type="RefSeq" id="XP_004570537.1">
        <property type="nucleotide sequence ID" value="XM_004570480.4"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BI96"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005009441"/>
    <dbReference type="Ensembl" id="ENSMZET00005009796.1">
        <property type="protein sequence ID" value="ENSMZEP00005009441.1"/>
        <property type="gene ID" value="ENSMZEG00005007143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472520"/>
    <dbReference type="KEGG" id="mze:101472520"/>
    <dbReference type="CTD" id="394039"/>
    <dbReference type="GeneTree" id="ENSGT00390000010302"/>
    <dbReference type="OrthoDB" id="496749at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009650">
        <property type="term" value="P:UV protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000002">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.80:FF:000004">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000110">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008148">
        <property type="entry name" value="DNA_photolyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032673">
        <property type="entry name" value="DNA_photolyase_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00591">
        <property type="entry name" value="phr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01083">
        <property type="entry name" value="DNA_PHOTOLYASES_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01084">
        <property type="entry name" value="DNA_PHOTOLYASES_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="17">
        <location>
            <begin position="120"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005009441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="557" mass="64205" checksum="2CD95911D010A35A" modified="2019-02-13" version="1">MLHCVWRSTSPFSAPGRFLKLLPHHHQRPSSPALFFLTSFFSCQPTMSGTKRKASSATAGKDHRAKQQKLAPVKQEKKEKVGGWLQSLVQLQRSEKKDVKFNKKRLRFLSDTEKIKQGSEGVLYWMLRDQRVQDNWALIHAQRLAVKENLPLHVCFCLVVPKSELSTLRHYSFMLKGLEEVAKECEQLNVQFHLLHGAPEKVLPGFVSDHSFGAVVTDFSPIREPLQWLEDVKKKLSKDIPFIQVDAHNIVPCWVASPKQEYSARTIRGKITNLLPEFLTDFPLVDAHPHTATRTAKGVDWDKTLASLDVDRNVKEPEWAKPGTKAGMDMLESFIDVRLKLFGSQRNDPNAPALSQLSPWLRFGQISAQRVAWQVQRNGKNASQSVPAFIEELVVRRELTDNFCFYNKKYDSVEGAYEWAQKTLKDHAKDERPYLYTREQLEKAKTHDKLWNAAQYQMVTEGKMHGFLRMYWAKKILEWTSSPEEALSIALYLNDRYELDGQDPNGFVGCMWSICGIHDQGWAERAVFGKIRYMNYKGCLRKFNVAQFERKYCPKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BNH5</accession>
    <name>A0A3P9BNH5_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="RefSeq" id="XP_024654336.1">
        <property type="nucleotide sequence ID" value="XM_024798568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BNH5"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011485"/>
    <dbReference type="Ensembl" id="ENSMZET00005011885.1">
        <property type="protein sequence ID" value="ENSMZEP00005011485.1"/>
        <property type="gene ID" value="ENSMZEG00005008610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101486750"/>
    <dbReference type="KEGG" id="mze:101486750"/>
    <dbReference type="GeneTree" id="ENSGT00940000154644"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042752">
        <property type="term" value="P:regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF472">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="327" mass="37220" checksum="CFCCDBFB54864E73" modified="2019-02-13" version="1">MAEGELDVDSLISRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGMNSGRPVTPPRTAQPPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BQJ7</accession>
    <name>A0A3P9BQJ7_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab GTPase-binding effector protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the rabaptin family.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9BQJ7"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005011896"/>
    <dbReference type="Ensembl" id="ENSMZET00005012304.1">
        <property type="protein sequence ID" value="ENSMZEP00005011896.1"/>
        <property type="gene ID" value="ENSMZEG00005008905.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063743"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003914">
        <property type="entry name" value="Rabaptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018514">
        <property type="entry name" value="Rabaptin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015390">
        <property type="entry name" value="Rabaptin_Rab5-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31179:SF6">
        <property type="entry name" value="RAB GTPASE-BINDING EFFECTOR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09311">
        <property type="entry name" value="Rab5-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03528">
        <property type="entry name" value="Rabaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="13 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rabaptin coiled-coil" evidence="19">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Rabaptin GTPase-Rab5 binding" evidence="20">
        <location>
            <begin position="212"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rabaptin GTPase-Rab5 binding" evidence="20">
        <location>
            <begin position="314"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="315"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03528"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF09311"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005011896.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="461" mass="51441" checksum="0C8BB7C323357703" modified="2019-02-13" version="1">FMTNGKYNNDYKTSLQAQLADYRAQVEHWQGVATICELSKQEELAELQKQCDQEIQSLQEALRETAAQYEARIAVLQSQPVEWKRSSGPHMVSVCPGRKGRVDAEHASVVNSLTEDESAPSTHSHPPELEAVPEGEGAALTTEGYFSLRNCDSASLSSFSLDTPSLPRKHHAQDDTDSLVSTGTLVPEAIYLPPAGHRLVTHSDWDALNAQLSELRGEVSRLQAEKEELERELDTQSNHTHKQVSTLQSQVQASESLLQDLQKSFSQSQNAVQSRLAELSLSQRKMCNELSRLKGEEVEEDVPDTGSSFSGAHCEERLRIEIVNLREQLDTQTEESVQFSSLKTETEKIHAQREQLQAELLACRTELEALRVALSHVQSTNKILSSEKATLNQQCLELRSQVISLRSQVDTSQAVQRDFVELSQSLQVKLELIRQAESLEQVKEILEEGHGEDNSPPVDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BR31</accession>
    <name>A0A3P9BR31_9CICH</name>
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        <recommendedName>
            <fullName evidence="3">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSMZET00005012806.1">
        <property type="protein sequence ID" value="ENSMZEP00005012374.1"/>
        <property type="gene ID" value="ENSMZEG00005009311.1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012374.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8544" checksum="36E3489D62458D0C" modified="2019-02-13" version="1">MQLYGAVILSVTLSAGKKNFFLRIFPSCLTALNAVTKGCLNSAACVWPMSCCEAELCNSAIPTGPSAILLLVSSAILKFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRC6</accession>
    <name>A0A3P9BRC6_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein heavy chain hydrolytic ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRC6"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012483"/>
    <dbReference type="Ensembl" id="ENSMZET00005012922.1">
        <property type="protein sequence ID" value="ENSMZEP00005012483.1"/>
        <property type="gene ID" value="ENSMZEG00005009383.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154791"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="279" mass="31508" checksum="5EEE16FBCE635889" modified="2019-02-13" version="1">MRAVKTVISAAGNLKRENPNMNELICLRAIQDVNVPKFLQDDLKLFNGIVSDLFPKIKQEPINYVFLKVFLLSLFLNELITELVGIPGYINKCIQLYETTVVRHGLMLVGPSGSGKTKVSHFHVVLVFNVFAVQTYVLNPKSITMGQLYGEYDLLTHEWTDGILSCLIRQGVASMDQKKKWYMFDGPVDAVWIENLNTVLDDNKKLCLSSGEIIKLTDVQDLAVASPATVSRCGMVYLEPSILGLTPFTECWLRQIPKALKPYKEMLSSLFDRFLQVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BRH9</accession>
    <name>A0A3P9BRH9_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear receptor binding factor 2b</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_004570434.1">
        <property type="nucleotide sequence ID" value="XM_004570377.5"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BRH9"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012529"/>
    <dbReference type="Ensembl" id="ENSMZET00005012973.1">
        <property type="protein sequence ID" value="ENSMZEP00005012529.1"/>
        <property type="gene ID" value="ENSMZEG00005009418.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101470288"/>
    <dbReference type="KEGG" id="mze:101470288"/>
    <dbReference type="CTD" id="436886"/>
    <dbReference type="GeneTree" id="ENSGT00390000000984"/>
    <dbReference type="OrthoDB" id="3694230at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039679">
        <property type="entry name" value="NRBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015056">
        <property type="entry name" value="NRBF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033393">
        <property type="entry name" value="NRBF2_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14964">
        <property type="entry name" value="NUCLEAR RECEPTOR BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14964:SF2">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08961">
        <property type="entry name" value="NRBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17169">
        <property type="entry name" value="NRBF2_MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140361">
        <property type="entry name" value="MIT domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear receptor-binding factor 2 MIT" evidence="4">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor-binding factor 2 C-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="306" mass="34104" checksum="8B2AD08C7C280DE3" modified="2019-02-13" version="1">MTVSEGQRRVSCSVSRRRIDSMEVVDSPLNLAHQQCRQADRLVAAGKYEEAISCHGKAADFLTEAMKAPVCEQARLSMELQRDSHIKQQRLIQERWKREARREAVKTRLGLVQATGPGFFSKSPSTGSSRPYASPGASAAELGSVGEREYDTLLYQLQTRQTGGTQILTPVCSGSKTTKDDKTRLEEQQTTIENLRLLVDGLTNENQQLRAENERLRLENMRLHSEAADFVERSELWVLPQAGGPMGTGVGQGGESKRKGKEIAIPQLPPLEMPAQEDLCLDDLPPLELPEDIQNELQELLDRDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BSH1</accession>
    <name>A0A3P9BSH1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45 cell division cycle 45 homolog (S. cerevisiae)</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547096.1">
        <property type="nucleotide sequence ID" value="XM_004547039.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BSH1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005012864"/>
    <dbReference type="Ensembl" id="ENSMZET00005013308.1">
        <property type="protein sequence ID" value="ENSMZEP00005012864.1"/>
        <property type="gene ID" value="ENSMZEG00005009621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101478843"/>
    <dbReference type="KEGG" id="mze:101478843"/>
    <dbReference type="CTD" id="8318"/>
    <dbReference type="GeneTree" id="ENSGT00390000009662"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005012864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="568" mass="65614" checksum="0DDCF3B9F7BDE2D3" modified="2019-02-13" version="1">MFIADIRKDFYEVVANQRVVLLVAPDIDALCACKILQALFHCDQIQYTLVPVTGWQDLGTAFLEHKEQFRYFVLINCGANVDLLEMLQPDDDSIFFICDTHRPVDVVNVYNDTQIKLLIKQDDDLSVPSYDDIFRDEDEEGEDSGNESDEGSEPSGKRRRFDEGAVERRIERQRAKREWEARRREILFDYEQYEYHGTSAAMMFFELAWVLTKDTKDMLWWAIIGLTDQWVHDKITNMKYVTDIATMQRHVSRHNHRNEDEENSLSIDCMRISFEYDLRLTLYQHWSLYESIYNSCYTSCSFKLWTLNGQKKLQEFLADMGLPLKQVRQKFNSMDMSIKENLRDVIEESSNKYGMKDIRIQTFGVHFGFKNRFLASDMVHATAALLESAEKDDSETDNFIKALDALSRSNIDRLHSGIALAKKKLIAIQQTVASCICTNLILSQGPFLYCYLMEGTPDVKLFSKPMALTLLCKYLLKAFVHSTRNKRCKLLPLVMAAPKDVEKGTVIVVGIPPESETSDKKNFFGRAFEKAAESTSSRTLHDHFDTSIIELKTEDRSKFLDALITLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BTQ0</accession>
    <name>A0A3P9BTQ0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Gastrula zinc finger protein XlCGF57.1</fullName>
        </submittedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004566034.1">
        <property type="nucleotide sequence ID" value="XM_004565977.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BTQ0"/>
    <dbReference type="Ensembl" id="ENSMZET00005013726.1">
        <property type="protein sequence ID" value="ENSMZEP00005013274.1"/>
        <property type="gene ID" value="ENSMZEG00005009978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101484462"/>
    <dbReference type="KEGG" id="mze:101484462"/>
    <dbReference type="GeneTree" id="ENSGT01150000286959"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001384">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002452">
        <property type="entry name" value="zinc finger protein 142 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="500" mass="57286" checksum="4A210958CCCBA1BD" modified="2019-02-13" version="1">MNEVDYLHQLNADSLAEEKPEIKRQQDAETSQSAVLPEDVRQLLVIKEVPQDWSPRRDLQAAEFLHIKQEQEEPWSSEEGQQINRLEEADLSRLPFTIVTVKTEDDDDEEKPQCSYRHQSQTEESTQTEPPIGCLAKQIKTEIEEDAYGRLESVWSPDLNCHLLVNNKKKTLDSSETEVSYEDEEEEEDVWQEPLSDSGPETEVGGIAWKESVATEPQFVSDVCVKTFTQPESQKRQRRGEKSLACAVCGKTFSCNTHLKRHMTVHTGEKPFSCEACGKRFGLEFTLKTHMRVHTGEKPFGCEDCGKTFSRNTHLKNHMRVHTQEKPFSCDSCGKTFKFKYSFKVHMRVHTGERPFGCSVCGKGFTEHEGLKRHMRIHTGEKPFGCDICGKRFGHQNALKRHTSVHTGEKPFGCDICGKRFNRSTRFKEHLRGHTGEKLFGCDECGKTFSSNTRLKRHMSIHRRDKQFLCGICGEKCSTSEQLKQHESSHMLLQIDTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVF1</accession>
    <name>A0A3P9BVF1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">trypsin</fullName>
            <ecNumber evidence="9">3.4.21.4</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.4" evidence="9"/>
    <dbReference type="RefSeq" id="XP_004554958.2">
        <property type="nucleotide sequence ID" value="XM_004554901.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVF1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005013616"/>
    <dbReference type="Ensembl" id="ENSMZET00005014081.1">
        <property type="protein sequence ID" value="ENSMZEP00005013616.1"/>
        <property type="gene ID" value="ENSMZEG00005010248.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mze:101464142"/>
    <dbReference type="GeneTree" id="ENSGT01030000234551"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000005">
        <property type="entry name" value="Serine protease 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF81">
        <property type="entry name" value="GRANZYME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017947590" description="trypsin" evidence="11">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="25"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005013616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="247" mass="27258" checksum="316780106A67DACF" modified="2019-02-13" version="1">MFTHCNLVVLIFVLILQDQVYTGEIIGGREVVPHSKPYMVLLELHNLGGHNKHCDGFLVNEDFVLTAGHCHAKSYKVFLGLHDYHNHNGVQHVSVPETNAFPHKDYNPVSYSNDIMLLKLSTKAVFNENVKPIDLADRDDGFAPKSCVVPGWGNTGNGKDSDVLLEVNVTLTENEICAKENKYCSEGATGPSTGDSGGPLVCEDGKAYGVVSASSNSMLDGLKLYSYIKISDKRDWIDSVIDHHRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BVU0</accession>
    <name>A0A3P9BVU0_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Carboxypeptidase Z</fullName>
        </submittedName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004538928.1">
        <property type="nucleotide sequence ID" value="XM_004538871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BVU0"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014105"/>
    <dbReference type="Ensembl" id="ENSMZET00005014578.1">
        <property type="protein sequence ID" value="ENSMZEP00005014105.1"/>
        <property type="gene ID" value="ENSMZEG00005010626.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472966"/>
    <dbReference type="KEGG" id="mze:101472966"/>
    <dbReference type="CTD" id="8532"/>
    <dbReference type="GeneTree" id="ENSGT00940000156391"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000012">
        <property type="entry name" value="Carboxypeptidase Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000021">
        <property type="entry name" value="Carboxypeptidase Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000022">
        <property type="entry name" value="Carboxypeptidase Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF63">
        <property type="entry name" value="CARBOXYPEPTIDASE Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018020768" evidence="13">
        <location>
            <begin position="19"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="14">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="189"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014105.1"/>
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        <source>
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        </source>
    </evidence>
    <sequence length="666" mass="75810" checksum="E81755C487C42C9B" modified="2019-02-13" version="1">MQLGLLVMFLFWAKTSLCVPQQNCHPGDEYLGRCSNSAYEEKPKCTELNLGYCNDMEYSRTIFPNILGHRTRLEAESGAEYLLLSVIHGLLNGECSPEIRLVGCSVLASPCRDDKMVKPCRSTCEALRKDCTHAFEAIEMAWPYFLDCDRFFASDQEGCFDPLAGLKARQEQALSSLSPQEPSTIIQFTYTSNAQMYSILKRTAAKCSHISHVYSIGRSTEGRDLLVIEFTNNPGQHELLEPEIKLVGNMHGNEVLGRQLLIYLAQYLCSEYILGNQRIQTIINTTRIHILASMNPDGYELAASEVEDNNDPELINHEGHLLNGWTNGRTNAQNIDLNRNFPDLTSVLYRNRRSRHYRTDHIPIPDAYWFGKVAPETYAVMKWVRSLPFVQSASLHGGDLVISYPFDYSRHPLEERMFSPTPDEQVFKQLARTYADAHATMSNNDTERCGASFYRTRGIINGALWYSFAGGMSDFNYLHTNCLEITVELGCDKFPSEAELYPEWKRNKEALLSFLESVHRGIKGIVKDGNGNGIKDATISIRGVRKDVTTAEDGDYWRLLNPGTHIVTATAKGYSKVSKRVYLPHTMSKAGRVDFVLQKVPVEPDIDDHLFPTSDTWDRFDPYNQFEQYRDPDVGDSGREREEKPWWWNYFSQSGISPPTWLLRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BX97</accession>
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            <taxon>Cichlomorphae</taxon>
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        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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    <dbReference type="Ensembl" id="ENSMZET00005015002.1">
        <property type="protein sequence ID" value="ENSMZEP00005014519.1"/>
        <property type="gene ID" value="ENSMZEG00005010925.1"/>
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        <property type="component" value="LG5"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="354"/>
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        </location>
    </feature>
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            <begin position="320"/>
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        </location>
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    </feature>
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            <begin position="222"/>
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    </feature>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXA8</accession>
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        <recommendedName>
            <fullName evidence="5 12">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
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            <taxon>Cichlomorphae</taxon>
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            <taxon>Haplochromini</taxon>
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            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
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                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
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                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
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                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
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                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
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                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
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                <person name="Yin S."/>
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                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="13" key="3">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with TMEM35A/NACHO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
            <topology evidence="2 12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004545385.1">
        <property type="nucleotide sequence ID" value="XM_004545328.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXA8"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014618"/>
    <dbReference type="Ensembl" id="ENSMZET00005015101.1">
        <property type="protein sequence ID" value="ENSMZEP00005014618.1"/>
        <property type="gene ID" value="ENSMZEG00005010995.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101463603"/>
    <dbReference type="KEGG" id="mze:101463603"/>
    <dbReference type="CTD" id="6184"/>
    <dbReference type="GeneTree" id="ENSGT00390000009630"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017855414" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="12">
        <location>
            <begin position="25"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="600" mass="67640" checksum="743C67E5CFA44942" modified="2019-02-13" version="1">MTQTSPLFTAYLLLLAALGPQVSADGLVNEDVKRTVDLSTHLAKITAEIVLSNQGNSAVHSFILAVEEGLAPHLAYIGASVKGDEEEDGTLELQQTTIQGQSGEFYKVQLPSSLAAGAQLKTKVEMTFSHVLKPFPTHITQAERQLVIFQGDHYFYSPYPTRTQTTRVRLASKTAESYTKLGNPSKTDEIIEYGPFRDIAPFSKDAMKIHYENNTPFLTISSITRTIEVSHWGNIAVEETIDLRHTGAILKGPFSRYDYQRQSDSGISSIKSFKTILPASAQDVYYRDEIGNISTSHLQVLDDSVEVEVRPRFPLFGGWKTHYIIGYNLPSYEYLYMLGDQYALKMRLVDHVYDDQVIDEMTVKIILPEGARNIHVDTPYKISRMPNQLHYTYLDTFGRPVLVATKNNLVEQHIQDFVVHYNFNKILMLQEPLLVVGAFYILFFTVIIYVRLDFAITKDPAAEVRMKVASITEQVLTLVNKRLGLYRHMDEVVNRYKQSRDTGGLNSGRKTLEADHRTLTNEISSLQARLKAEGSDLADKVGEVQKLDGQVKELVCRSCQEAERLVAGKVKKEAYIESEKNLTSKRQELVGRIDSLLDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BXI1</accession>
    <name>A0A3P9BXI1_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-responsive element-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004570327.1">
        <property type="nucleotide sequence ID" value="XM_004570270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3P9BXI1"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005014552"/>
    <dbReference type="Ensembl" id="ENSMZET00005015035.1">
        <property type="protein sequence ID" value="ENSMZEP00005014552.1"/>
        <property type="gene ID" value="ENSMZEG00005010935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101467258"/>
    <dbReference type="KEGG" id="mze:101467258"/>
    <dbReference type="CTD" id="3658"/>
    <dbReference type="GeneTree" id="ENSGT00940000157796"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030350">
        <property type="term" value="F:iron-responsive element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000011">
        <property type="entry name" value="Iron-responsive element binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000012">
        <property type="entry name" value="Iron-responsive element binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000005">
        <property type="entry name" value="Iron-responsive element-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="71"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="210"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="773"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005014552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="968" mass="105919" checksum="FE4A9910636701B1" modified="2019-02-13" version="1">MAHTSPVKEHPYSHLIDTLKDGQIKFFNPYKLNDPRYDKLPLSIRVLLEAAIRNCDGFYTKQEDVQNILHWQQEQNKAEVPFSPARVLLQDFTGIPAMVDLAAMRDAVAKHGVDPSLVNPKCPTDLIVDHSLQIDYSKCAIQNAPNPGGGEGPSQGPSRSVHSRPPSRGGAQCGGQRGSCSKAACSDSPGGSPASVQQIENTPLLCPFHLQPVSEVETALRNQEMELIRNKERLQFFKWCSKAFKNVNVVPPDVGAVHQLNLEYLSRVVQVSDGFIYPDSVVGTDSHTTMINGLGILGWGVGGIESEAIMLGQPISLTLPQVVGCKLVGSINPLTTSIDIVLGITKHLRQAGIAGKFVEFFGPGVSQLSVPDRTTIANMCPEYNATVSFFPVDQVTLKHFKKTNFTQEKLELLESYMKAVKLFRSYDDPSEDPQYSEVIEFNLSSMVPYVSGPKRPQDRVAVSSMKEDFQSCLDEKVGFKGFHIAKEKQEIRVPFLHGGQEYQLSHGSVVIAAVISCTNNCNPSVMLTAGLLARKAVEAGLLVKPYIRTSLAPGSGMVTHYLNASGVLPYFNKLGFEVIGYGCATCVGNTAPLPEAVVDAIKQGDLVACGVLSGNRHFEGRLCDCVRANYLASPPLVVAYAIAGTVGVDFEKEPLGLTSDGKEVYLRDIWPSREEVQQIEEDTVFSSIFKDLRGRMEKGNTFWKNVECSDSLLFPWDHKSTYIRSPSFFSKLSKEVPPPQSIENAHALLFLGDKVTTDHISPAGSIARVSAAAKYLMSKRLTPREFNSYGARRGNDAVMTRGTFASIKLQNRFIGKPGPKTLHIPSGQTLDVFEAADRYQRDGIPLIILAGKDYGSGNSRDWVAKGPYLLGVRAVIAESFEKLHRNQLVGMGIMPLQFLSGQNADSLELSGKERFSITLPESLSPGQELTVKTSQGKSFSVTALFDSDTDVILFQHGGLLRYVARTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9BY02</accession>
    <name>A0A3P9BY02_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FH1/FH2 domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."/>
                <person name="Bloomquist R."/>
                <person name="Carleton K.L."/>
                <person name="Conte M.A."/>
                <person name="D'Cotta H."/>
                <person name="Eshel O."/>
                <person name="Gaffney L."/>
                <person name="Galibert F."/>
                <person name="Gante H.F."/>
                <person name="Gnerre S."/>
                <person name="Greuter L."/>
                <person name="Guyon R."/>
                <person name="Haddad N.S."/>
                <person name="Haerty W."/>
                <person name="Harris R.M."/>
                <person name="Hofmann H.A."/>
                <person name="Hourlier T."/>
                <person name="Hulata G."/>
                <person name="Jaffe D.B."/>
                <person name="Lara M."/>
                <person name="Lee A.P."/>
                <person name="MacCallum I."/>
                <person name="Mwaiko S."/>
                <person name="Nikaido M."/>
                <person name="Nishihara H."/>
                <person name="Ozouf-Costaz C."/>
                <person name="Penman D.J."/>
                <person name="Przybylski D."/>
                <person name="Rakotomanga M."/>
                <person name="Renn S.C.P."/>
                <person name="Ribeiro F.J."/>
                <person name="Ron M."/>
                <person name="Salzburger W."/>
                <person name="Sanchez-Pulido L."/>
                <person name="Santos M.E."/>
                <person name="Searle S."/>
                <person name="Sharpe T."/>
                <person name="Swofford R."/>
                <person name="Tan F.J."/>
                <person name="Williams L."/>
                <person name="Young S."/>
                <person name="Yin S."/>
                <person name="Okada N."/>
                <person name="Kocher T.D."/>
                <person name="Miska E.A."/>
                <person name="Lander E.S."/>
                <person name="Venkatesh B."/>
                <person name="Fernald R.D."/>
                <person name="Meyer A."/>
                <person name="Ponting C.P."/>
                <person name="Streelman J.T."/>
                <person name="Lindblad-Toh K."/>
                <person name="Seehausen O."/>
                <person name="Di Palma F."/>
            </authorList>
            <dbReference type="PubMed" id="25186727"/>
            <dbReference type="DOI" id="10.1038/nature13726"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_004547828.1">
        <property type="nucleotide sequence ID" value="XM_004547771.5"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMZET00005015266.1">
        <property type="protein sequence ID" value="ENSMZEP00005014779.1"/>
        <property type="gene ID" value="ENSMZEG00005011129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="101472710"/>
    <dbReference type="KEGG" id="mze:101472710"/>
    <dbReference type="CTD" id="564742"/>
    <dbReference type="GeneTree" id="ENSGT00940000154807"/>
    <dbReference type="OrthoDB" id="9806920at2759"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="LG22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055003">
        <property type="term" value="P:cardiac myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000056">
        <property type="entry name" value="FH1/FH2 domain-containing protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000004">
        <property type="entry name" value="Formin homology 2 domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056771">
        <property type="entry name" value="FH3_FHOD1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041387">
        <property type="entry name" value="FHOD1_GBD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920:SF3">
        <property type="entry name" value="FH1_FH2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45920">
        <property type="entry name" value="FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24959">
        <property type="entry name" value="FH3_FHOD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18382">
        <property type="entry name" value="Formin_GBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="9">
        <location>
            <begin position="18"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="8">
        <location>
            <begin position="1565"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="323"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="413"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="532"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="683"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="879"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1444"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1575"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="481"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51231"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="1628" mass="183092" checksum="A4AFAE0FA46E4A86" modified="2019-02-13" version="1">MATFVCRVQFLDDTDPFNSTNFPEPTRPPLYSFREDIPLINQLAGVHRLLKAPHKLDDCALQLSHNGTYLDLESSLAEQRDELEGFQQDDTGSRGKKHSVILRTQLTVRVHACIERLYNSNGRDLRRALFSLKQIFQDDKDLVHEFVMAEGLTCLIKVGAEADQNYQNYILRALGQIMLYVDGMNGVIGHPETIQWLYTLVGSKFRLVVKTALKLLLVFVEYSESNAPLLIQAITSVDMKRGSKPWSNAMEILHEKDGVDTELLVYAMTLINKTLAALPDQDSFYDMVDGLEEQGMETVSQRHLGRKGTDLDLVEQLNIYETTLRHEDGDDDSQPPPMVRRDRRRASVGGGDKRHGLERRRSRRASLGRSGYASPCSPASPQRAGFQPFNGIRSEDVSERALSGYLQSIVEECEEDSIEEEKEEEEEETPVTESDSDEQEGANETTSSPARHLPSTVQRTTLQSITITSRKESVKETEQRNWSEPTSATTTTSSISSPSTPTLSPTVSCTHSPPGQPSLLATLLARKKSIVTVPATKEVSPPLRGSSRPSPDRLPYLPHSPFHLFSYDLDEEPSPPALGKPSEESPKPTTPRNGALTSYSSLSTPSTPTSSRPALGGLLSSSYRQHQESLAAERERRRVEREERLQKIEREERNKHSRGYVDKMEEARLAREERYKNVERLAAEEYERERVRVSRNQPAVDLNFEPSEAWPPSSSRSSTPSSFASQEDAEAELEAETPTAVPCTPPETEEANNFSASVDAEEKEAEATAEEEEGRKDVEIEEEVTAEREEEEVEEQAEEPEKEREEAEEDSGILSDKERQNEEVNEKDNCSASSISSASSTLEREERGSNESGFKEAEVNENCNKLLNSKLFMLDMLYSQNKKPSDEEEEEDVDKEKGEGEDKEAQQDANRQPGEDQEKNSRDEKSDHRGSIRPIAERFGDLIKDISTTHAHLDSPANEPPPPPPKKESDTIWDQLLASPRELRIGDINFTDLTEEDDKDILDAVLMGGCGELPPLPPPPPCIPRFPPPPPMLGSCPPPPPLFGSMRPPPPPSFNALIPVPPPPEPPLFNKKKKTIRLFWSEVRPTDCQYRDYKRSGESFWSKLEPVKLDTAKLEHLFETKSKEIPVTKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKTAILNFDEYALNKEGIEKILTMIPTEEEKQKIQEAQLANPDVPLGSAEQFLLTLSSISELSARLQLWAFKMDYEATEKEVAEPLQDLKEGMDQLEKNKTIRYVLSTLLSIGNFLNGTNAKGFELTYLEKVPEVKDTVHKQSLLHHVCSVVVENFPQSTDLYSEIGAITRSAKVDFDQLQENLCQMERRCKASWDHLKVIAKHEMKPQLKQKMSDFLKDCAERIIILKIVHRRIINRFHSFLLFLGHPAYSVREISVHRFSKILSEFALEYRTTRERVLQQKQKRADHRERNKTRGKMIMDVNTASDDEEERECGRSSAGSNNSAPSGGQEIEQPQGLEHAEDAAEHEHMKAVLRTSLSGSDKEGSGVPGLRTRTRSRPGRGGRSMQAWTPPVEDPQICGDDAADEIMERIVRSATQGPGTRTQPRERRRSRANRKSLRRTLKNGLTPEEALALGLTDSPEPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C0W4</accession>
    <name>A0A3P9C0W4_9CICH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A3P9C0W4"/>
    <dbReference type="STRING" id="106582.ENSMZEP00005015814"/>
    <dbReference type="Ensembl" id="ENSMZET00005016323.1">
        <property type="protein sequence ID" value="ENSMZEP00005015814.1"/>
        <property type="gene ID" value="ENSMZEG00005011877.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164791"/>
    <dbReference type="Proteomes" id="UP000265160">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMZEP00005015814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000265160"/>
        </source>
    </evidence>
    <sequence length="142" mass="15085" checksum="612F29B765040717" modified="2019-02-13" version="1">MATTGMQLLGLILSIVGWVGGLVVCAIPSQIIWEGLWMNCIVQSTGEIQCKVYDSLLALPSDMQAARGLTVLSILLCGLALALGVLGVKCTKCIGVNSLKARIARISGSLFAIAGFLYLVPVCWTAHSIIRDFYDPHVAGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-02-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3P9C2B1</accession>
    <name>A0A3P9C2B1_9CICH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zona pellucida glycoprotein 3f, tandem duplicate 1</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Maylandia zebra</name>
        <name type="common">zebra mbuna</name>
        <dbReference type="NCBI Taxonomy" id="106582"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Actinopterygii</taxon>
            <taxon>Neopterygii</taxon>
            <taxon>Teleostei</taxon>
            <taxon>Neoteleostei</taxon>
            <taxon>Acanthomorphata</taxon>
            <taxon>Ovalentaria</taxon>
            <taxon>Cichlomorphae</taxon>
            <taxon>Cichliformes</taxon>
            <taxon>Cichlidae</taxon>
            <taxon>African cichlids</taxon>
            <taxon>Pseudocrenilabrinae</taxon>
            <taxon>Haplochromini</taxon>
            <taxon>Maylandia</taxon>
            <taxon>Maylandia zebra complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="Nature" volume="513" first="375" last="381">
            <title>The genomic substrate for adaptive radiation in African cichlid fish.</title>
            <authorList>
                <person name="Brawand D."/>
                <person name="Wagner C.E."/>
                <person name="Li Y.I."/>
                <person name="Malinsky M."/>
                <person name="Keller I."/>
                <person name="Fan S."/>
                <person name="Simakov O."/>
                <person name="Ng A.Y."/>
                <person name="Lim Z.W."/>
                <person name="Bezault E."/>
                <person name="Turner-Maier J."/>
                <person name="Johnson J."/>
                <person name="Alcazar R."/>
                <person name="Noh H.J."/>
                <person name="Russell P."/>
                <person name="Aken B."/>
                <person name="Alfoldi J."/>
                <person name="Amemiya C."/>
                <person name="Azzouzi N."/>
                <person name="Baroiller J.F."/>
                <person name="Barloy-Hubler F."/>
                <person name="Berlin A."
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